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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CLYBL-ARGLU1 (FusionGDB2 ID:HG171425TG55082)

Fusion Gene Summary for CLYBL-ARGLU1

check button Fusion gene summary
Fusion gene informationFusion gene name: CLYBL-ARGLU1
Fusion gene ID: hg171425tg55082
HgeneTgene
Gene symbol

CLYBL

ARGLU1

Gene ID

171425

55082

Gene namecitramalyl-CoA lyasearginine and glutamate rich 1
SynonymsCLB-
Cytomap('CLYBL')('ARGLU1')

13q32.3

13q33.3

Type of geneprotein-codingprotein-coding
Descriptioncitramalyl-CoA lyase, mitochondrial(3S)-malyl-CoA thioesterasebeta-methylmalate synthasecitrate lyase beta likecitrate lyase subunit beta-like protein, mitochondrialmalate synthasearginine and glutamate-rich protein 1
Modification date2020031320200313
UniProtAcc.

Q9NWB6

Ensembl transtripts involved in fusion geneENST00000339105, ENST00000376354, 
ENST00000376355, ENST00000376360, 
ENST00000444838, 
Fusion gene scores* DoF score7 X 8 X 4=2248 X 7 X 3=168
# samples 88
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLYBL [Title/Abstract] AND ARGLU1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLYBL(100259011)-ARGLU1(107212005), # samples:1
Anticipated loss of major functional domain due to fusion event.CLYBL-ARGLU1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLYBL-ARGLU1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLYBL

GO:0070207

protein homotrimerization

29056341

HgeneCLYBL

GO:0106064

regulation of cobalamin metabolic process

29056341


check buttonFusion gene breakpoints across CLYBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ARGLU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer135NCLYBLchr13

100259011

+ARGLU1chr13

107212005

-


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Fusion Gene ORF analysis for CLYBL-ARGLU1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000339105ENST00000375926CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
5CDS-5UTRENST00000376354ENST00000375926CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
5CDS-5UTRENST00000376355ENST00000375926CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
5CDS-5UTRENST00000376360ENST00000375926CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
5CDS-5UTRENST00000444838ENST00000375926CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
5CDS-intronENST00000339105ENST00000472226CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
5CDS-intronENST00000376354ENST00000472226CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
5CDS-intronENST00000376355ENST00000472226CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
5CDS-intronENST00000376360ENST00000472226CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
5CDS-intronENST00000444838ENST00000472226CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
In-frameENST00000339105ENST00000400198CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
In-frameENST00000376354ENST00000400198CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
In-frameENST00000376355ENST00000400198CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
In-frameENST00000376360ENST00000400198CLYBLchr13

100259011

+ARGLU1chr13

107212005

-
In-frameENST00000444838ENST00000400198CLYBLchr13

100259011

+ARGLU1chr13

107212005

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376355CLYBLchr13100259011+ENST00000400198ARGLU1chr13107212005-28919331567178
ENST00000444838CLYBLchr13100259011+ENST00000400198ARGLU1chr13107212005-28878927563178
ENST00000376360CLYBLchr13100259011+ENST00000400198ARGLU1chr13107212005-28878927563178
ENST00000376354CLYBLchr13100259011+ENST00000400198ARGLU1chr13107212005-2866686542178
ENST00000339105CLYBLchr13100259011+ENST00000400198ARGLU1chr13107212005-2860620536178

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376355ENST00000400198CLYBLchr13100259011+ARGLU1chr13107212005-0.0001214930.9998785
ENST00000444838ENST00000400198CLYBLchr13100259011+ARGLU1chr13107212005-9.68E-050.9999032
ENST00000376360ENST00000400198CLYBLchr13100259011+ARGLU1chr13107212005-9.68E-050.9999032
ENST00000376354ENST00000400198CLYBLchr13100259011+ARGLU1chr13107212005-9.60E-050.9999039
ENST00000339105ENST00000400198CLYBLchr13100259011+ARGLU1chr13107212005-0.0001360070.999864

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Fusion Genomic Features for CLYBL-ARGLU1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CLYBL-ARGLU1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:100259011/chr13:107212005)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARGLU1

Q9NWB6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. {ECO:0000269|PubMed:21454576}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLYBLchr13:100259011chr13:107212005ENST00000339105+19272_27320361.0RegionSubstrate binding
HgeneCLYBLchr13:100259011chr13:107212005ENST00000376354+17272_27320307.0RegionSubstrate binding
HgeneCLYBLchr13:100259011chr13:107212005ENST00000376355+18272_273201839.6666666666667RegionSubstrate binding
HgeneCLYBLchr13:100259011chr13:107212005ENST00000376360+18272_27320341.0RegionSubstrate binding
TgeneARGLU1chr13:100259011chr13:107212005ENST00000400198043_74115274.0Compositional biasNote=Arg-rich
TgeneARGLU1chr13:100259011chr13:107212005ENST000004001980497_251115274.0Compositional biasNote=Glu-rich


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Fusion Gene Sequence for CLYBL-ARGLU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17476_17476_1_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000339105_ARGLU1_chr13_107212005_ENST00000400198_length(transcript)=2860nt_BP=62nt
ATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTTCGACAGCAAGAAATAGAAGAAAAACTC
ATCGAGGAAGAAACAGCACGAAGAGTAGAAGAATTGGTAGCAAAAAGGGTGGAGGAAGAACTGGAGAAAAGGAAGGATGAAATTGAACGA
GAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGAACTCGAGCGACAGAGACAAGCTGAGCTTGCC
GCACAAAAAGCTAGAGAGGAGGAAGAACGTGCAAAACGTGAGGAGCTAGAGCGAATACTGGAAGAGAATAACCGAAAAATTGCAGAAGCA
CAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGAGGAAAGGATGAAACTAGAACAAGAACGACAA
CGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACTGTCCTTCTCATTAAAAACCCAGGATTAAATT
GCAAACTCTGAACTTTTTACAAAGAAAAATGGAAAAACTTTGTATGGTAGCTTCATGTTGAAGTGGTTTTTTGTTTTTGTTTTTGTTTTT
TTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCCCTTTTTTTTTTTTTTTTTCCTTCCACTAAGT
CAAATCCTTATCAGATCATTGTTGTATTCTAAGGAGTGACGTATTTTTCACCTGTTTGGATTCTATATTAGTGGTCTGAGGAAGAGCAGA
TCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGAGTTATACTCTGTTTGCTACATCATAATGCTG
GTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGCATTGGGAAATTCCCAGGGTATTACTGGACCT
ATGTGGTGTATTGTTAAACCAGTGTCCTTGTGATACTGTTGCTCTTGATGTTCCTGATACAGGTAAGGAAACAGTTGGTCAACTCTGATA
CAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAAAATCAAACCAGCATTCCCCATTGTGTAAATA
AATGATTTTGCTGAATAAAGTAAAGTCTTAAATTCATATGTTGAAGCAATTTTTTTTAATGTTATGTTAAGTCTTAAAGAGGGTGGTTCA
CTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTTTAACATAGGGTTTATATGTACATTAAATATA
CTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCAAATGGCATCAGTGTTACCTTTAAGAAAGACT
AACAACATCCAGAAGATTTAAATTCTCAAACCTGTGCCTCTGTTTTAGGATATAAGTATTATCACAAAGTATACTTAATAAAGGCTAGAA
AAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACTTAGCTTTATACTGTCAAAAAAAGGCTAAGAT
GGTCGAGTCATTTTCATTGTGTAGTGTACTTGCACGTTTATTTTTAGGACAAACACATTTGAACTTTATGAATTTTTTTTTTTTTTTTGC
ATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTTAACATATGTTTAAGTATACTGGTATTAAAAC
ATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAGTAGAGAAAATATTTTTATTTTTGCCCAATAT
TTTTTAGACAGTTTGATTATTCTTAAAAATTGAAAACATAAGCTAAAGAGATGACTAAATGGTAGATTATTTTGTGTGTGCATGCTAGGA
AAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAATATAAAATCAGTTTAAAGATCTTTAAAGGTAG
AATTTTAAATAGGCATGAAATATAGTGAGAACTTTTAGTAAACATACTACTTACTCTAAAATCAAACATTTTATTTTCCTAAAGAATATA
GGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTTTTTTTTTTTTCAATGTAACTTTTTTTGGTGA
AGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGTTCTATACAAGTGTTCAAAACATTGTATCTAA
AGAGAGTAGCCTGGACTTAAAATATTTGAAATCAGCTTATGCGTGCCTTTTAATTTTTTTTTTAAGTTTCTTACTGCCACATATGGTGTG
AAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCAGTGAGATGTTGAAATTGTTCCTGTGCTTGGT
AACTACTTTCCTCTGCCAGGCTATGGGAAAGAGGATGTAATTGTGAATAATATACACCATCCAGTCTTTAATGTGCTGCAACAATGTAGT
AATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTCCCCCAGTCTATTAGAAGTTAAGATGTTCCCT
AATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTATAGAATTAAGTATGACTTTGTTTATTTTTAT

>17476_17476_1_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000339105_ARGLU1_chr13_107212005_ENST00000400198_length(amino acids)=178AA_BP=21
MALRLLRRAARGAAAAALLRLRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELA

--------------------------------------------------------------
>17476_17476_2_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000376354_ARGLU1_chr13_107212005_ENST00000400198_length(transcript)=2866nt_BP=68nt
GGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTTCGACAGCAAGAAATAGAAGAA
AAACTCATCGAGGAAGAAACAGCACGAAGAGTAGAAGAATTGGTAGCAAAAAGGGTGGAGGAAGAACTGGAGAAAAGGAAGGATGAAATT
GAACGAGAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGAACTCGAGCGACAGAGACAAGCTGAG
CTTGCCGCACAAAAAGCTAGAGAGGAGGAAGAACGTGCAAAACGTGAGGAGCTAGAGCGAATACTGGAAGAGAATAACCGAAAAATTGCA
GAAGCACAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGAGGAAAGGATGAAACTAGAACAAGAA
CGACAACGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACTGTCCTTCTCATTAAAAACCCAGGAT
TAAATTGCAAACTCTGAACTTTTTACAAAGAAAAATGGAAAAACTTTGTATGGTAGCTTCATGTTGAAGTGGTTTTTTGTTTTTGTTTTT
GTTTTTTTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCCCTTTTTTTTTTTTTTTTTCCTTCCA
CTAAGTCAAATCCTTATCAGATCATTGTTGTATTCTAAGGAGTGACGTATTTTTCACCTGTTTGGATTCTATATTAGTGGTCTGAGGAAG
AGCAGATCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGAGTTATACTCTGTTTGCTACATCATA
ATGCTGGTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGCATTGGGAAATTCCCAGGGTATTACT
GGACCTATGTGGTGTATTGTTAAACCAGTGTCCTTGTGATACTGTTGCTCTTGATGTTCCTGATACAGGTAAGGAAACAGTTGGTCAACT
CTGATACAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAAAATCAAACCAGCATTCCCCATTGTG
TAAATAAATGATTTTGCTGAATAAAGTAAAGTCTTAAATTCATATGTTGAAGCAATTTTTTTTAATGTTATGTTAAGTCTTAAAGAGGGT
GGTTCACTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTTTAACATAGGGTTTATATGTACATTA
AATATACTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCAAATGGCATCAGTGTTACCTTTAAGA
AAGACTAACAACATCCAGAAGATTTAAATTCTCAAACCTGTGCCTCTGTTTTAGGATATAAGTATTATCACAAAGTATACTTAATAAAGG
CTAGAAAAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACTTAGCTTTATACTGTCAAAAAAAGGC
TAAGATGGTCGAGTCATTTTCATTGTGTAGTGTACTTGCACGTTTATTTTTAGGACAAACACATTTGAACTTTATGAATTTTTTTTTTTT
TTTTGCATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTTAACATATGTTTAAGTATACTGGTAT
TAAAACATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAGTAGAGAAAATATTTTTATTTTTGCC
CAATATTTTTTAGACAGTTTGATTATTCTTAAAAATTGAAAACATAAGCTAAAGAGATGACTAAATGGTAGATTATTTTGTGTGTGCATG
CTAGGAAAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAATATAAAATCAGTTTAAAGATCTTTAA
AGGTAGAATTTTAAATAGGCATGAAATATAGTGAGAACTTTTAGTAAACATACTACTTACTCTAAAATCAAACATTTTATTTTCCTAAAG
AATATAGGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTTTTTTTTTTTTCAATGTAACTTTTTT
TGGTGAAGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGTTCTATACAAGTGTTCAAAACATTGT
ATCTAAAGAGAGTAGCCTGGACTTAAAATATTTGAAATCAGCTTATGCGTGCCTTTTAATTTTTTTTTTAAGTTTCTTACTGCCACATAT
GGTGTGAAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCAGTGAGATGTTGAAATTGTTCCTGTG
CTTGGTAACTACTTTCCTCTGCCAGGCTATGGGAAAGAGGATGTAATTGTGAATAATATACACCATCCAGTCTTTAATGTGCTGCAACAA
TGTAGTAATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTCCCCCAGTCTATTAGAAGTTAAGATG
TTCCCTAATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTATAGAATTAAGTATGACTTTGTTTAT

>17476_17476_2_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000376354_ARGLU1_chr13_107212005_ENST00000400198_length(amino acids)=178AA_BP=21
MALRLLRRAARGAAAAALLRLRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELA

--------------------------------------------------------------
>17476_17476_3_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000376355_ARGLU1_chr13_107212005_ENST00000400198_length(transcript)=2891nt_BP=93nt
AGGCAAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAG
GCTTCGACAGCAAGAAATAGAAGAAAAACTCATCGAGGAAGAAACAGCACGAAGAGTAGAAGAATTGGTAGCAAAAAGGGTGGAGGAAGA
ACTGGAGAAAAGGAAGGATGAAATTGAACGAGAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGA
ACTCGAGCGACAGAGACAAGCTGAGCTTGCCGCACAAAAAGCTAGAGAGGAGGAAGAACGTGCAAAACGTGAGGAGCTAGAGCGAATACT
GGAAGAGAATAACCGAAAAATTGCAGAAGCACAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGA
GGAAAGGATGAAACTAGAACAAGAACGACAACGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACT
GTCCTTCTCATTAAAAACCCAGGATTAAATTGCAAACTCTGAACTTTTTACAAAGAAAAATGGAAAAACTTTGTATGGTAGCTTCATGTT
GAAGTGGTTTTTTGTTTTTGTTTTTGTTTTTTTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCC
CTTTTTTTTTTTTTTTTTCCTTCCACTAAGTCAAATCCTTATCAGATCATTGTTGTATTCTAAGGAGTGACGTATTTTTCACCTGTTTGG
ATTCTATATTAGTGGTCTGAGGAAGAGCAGATCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGA
GTTATACTCTGTTTGCTACATCATAATGCTGGTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGC
ATTGGGAAATTCCCAGGGTATTACTGGACCTATGTGGTGTATTGTTAAACCAGTGTCCTTGTGATACTGTTGCTCTTGATGTTCCTGATA
CAGGTAAGGAAACAGTTGGTCAACTCTGATACAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAA
AATCAAACCAGCATTCCCCATTGTGTAAATAAATGATTTTGCTGAATAAAGTAAAGTCTTAAATTCATATGTTGAAGCAATTTTTTTTAA
TGTTATGTTAAGTCTTAAAGAGGGTGGTTCACTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTT
TAACATAGGGTTTATATGTACATTAAATATACTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCA
AATGGCATCAGTGTTACCTTTAAGAAAGACTAACAACATCCAGAAGATTTAAATTCTCAAACCTGTGCCTCTGTTTTAGGATATAAGTAT
TATCACAAAGTATACTTAATAAAGGCTAGAAAAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACT
TAGCTTTATACTGTCAAAAAAAGGCTAAGATGGTCGAGTCATTTTCATTGTGTAGTGTACTTGCACGTTTATTTTTAGGACAAACACATT
TGAACTTTATGAATTTTTTTTTTTTTTTTGCATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTT
AACATATGTTTAAGTATACTGGTATTAAAACATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAG
TAGAGAAAATATTTTTATTTTTGCCCAATATTTTTTAGACAGTTTGATTATTCTTAAAAATTGAAAACATAAGCTAAAGAGATGACTAAA
TGGTAGATTATTTTGTGTGTGCATGCTAGGAAAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAAT
ATAAAATCAGTTTAAAGATCTTTAAAGGTAGAATTTTAAATAGGCATGAAATATAGTGAGAACTTTTAGTAAACATACTACTTACTCTAA
AATCAAACATTTTATTTTCCTAAAGAATATAGGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTT
TTTTTTTTTTCAATGTAACTTTTTTTGGTGAAGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGT
TCTATACAAGTGTTCAAAACATTGTATCTAAAGAGAGTAGCCTGGACTTAAAATATTTGAAATCAGCTTATGCGTGCCTTTTAATTTTTT
TTTTAAGTTTCTTACTGCCACATATGGTGTGAAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCA
GTGAGATGTTGAAATTGTTCCTGTGCTTGGTAACTACTTTCCTCTGCCAGGCTATGGGAAAGAGGATGTAATTGTGAATAATATACACCA
TCCAGTCTTTAATGTGCTGCAACAATGTAGTAATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTC
CCCCAGTCTATTAGAAGTTAAGATGTTCCCTAATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTA
TAGAATTAAGTATGACTTTGTTTATTTTTATTACAGTATGTAGTTATTGACATATTGTGGTTTGCAGAATTATCAATTGTATAAACTAAA

>17476_17476_3_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000376355_ARGLU1_chr13_107212005_ENST00000400198_length(amino acids)=178AA_BP=21
MALRLLRRAARGAAAAALLRLRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELA

--------------------------------------------------------------
>17476_17476_4_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000376360_ARGLU1_chr13_107212005_ENST00000400198_length(transcript)=2887nt_BP=89nt
AAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTT
CGACAGCAAGAAATAGAAGAAAAACTCATCGAGGAAGAAACAGCACGAAGAGTAGAAGAATTGGTAGCAAAAAGGGTGGAGGAAGAACTG
GAGAAAAGGAAGGATGAAATTGAACGAGAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGAACTC
GAGCGACAGAGACAAGCTGAGCTTGCCGCACAAAAAGCTAGAGAGGAGGAAGAACGTGCAAAACGTGAGGAGCTAGAGCGAATACTGGAA
GAGAATAACCGAAAAATTGCAGAAGCACAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGAGGAA
AGGATGAAACTAGAACAAGAACGACAACGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACTGTCC
TTCTCATTAAAAACCCAGGATTAAATTGCAAACTCTGAACTTTTTACAAAGAAAAATGGAAAAACTTTGTATGGTAGCTTCATGTTGAAG
TGGTTTTTTGTTTTTGTTTTTGTTTTTTTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCCCTTT
TTTTTTTTTTTTTTCCTTCCACTAAGTCAAATCCTTATCAGATCATTGTTGTATTCTAAGGAGTGACGTATTTTTCACCTGTTTGGATTC
TATATTAGTGGTCTGAGGAAGAGCAGATCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGAGTTA
TACTCTGTTTGCTACATCATAATGCTGGTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGCATTG
GGAAATTCCCAGGGTATTACTGGACCTATGTGGTGTATTGTTAAACCAGTGTCCTTGTGATACTGTTGCTCTTGATGTTCCTGATACAGG
TAAGGAAACAGTTGGTCAACTCTGATACAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAAAATC
AAACCAGCATTCCCCATTGTGTAAATAAATGATTTTGCTGAATAAAGTAAAGTCTTAAATTCATATGTTGAAGCAATTTTTTTTAATGTT
ATGTTAAGTCTTAAAGAGGGTGGTTCACTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTTTAAC
ATAGGGTTTATATGTACATTAAATATACTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCAAATG
GCATCAGTGTTACCTTTAAGAAAGACTAACAACATCCAGAAGATTTAAATTCTCAAACCTGTGCCTCTGTTTTAGGATATAAGTATTATC
ACAAAGTATACTTAATAAAGGCTAGAAAAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACTTAGC
TTTATACTGTCAAAAAAAGGCTAAGATGGTCGAGTCATTTTCATTGTGTAGTGTACTTGCACGTTTATTTTTAGGACAAACACATTTGAA
CTTTATGAATTTTTTTTTTTTTTTTGCATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTTAACA
TATGTTTAAGTATACTGGTATTAAAACATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAGTAGA
GAAAATATTTTTATTTTTGCCCAATATTTTTTAGACAGTTTGATTATTCTTAAAAATTGAAAACATAAGCTAAAGAGATGACTAAATGGT
AGATTATTTTGTGTGTGCATGCTAGGAAAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAATATAA
AATCAGTTTAAAGATCTTTAAAGGTAGAATTTTAAATAGGCATGAAATATAGTGAGAACTTTTAGTAAACATACTACTTACTCTAAAATC
AAACATTTTATTTTCCTAAAGAATATAGGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTTTTTT
TTTTTTCAATGTAACTTTTTTTGGTGAAGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGTTCTA
TACAAGTGTTCAAAACATTGTATCTAAAGAGAGTAGCCTGGACTTAAAATATTTGAAATCAGCTTATGCGTGCCTTTTAATTTTTTTTTT
AAGTTTCTTACTGCCACATATGGTGTGAAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCAGTGA
GATGTTGAAATTGTTCCTGTGCTTGGTAACTACTTTCCTCTGCCAGGCTATGGGAAAGAGGATGTAATTGTGAATAATATACACCATCCA
GTCTTTAATGTGCTGCAACAATGTAGTAATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTCCCCC
AGTCTATTAGAAGTTAAGATGTTCCCTAATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTATAGA
ATTAAGTATGACTTTGTTTATTTTTATTACAGTATGTAGTTATTGACATATTGTGGTTTGCAGAATTATCAATTGTATAAACTAAACCTT

>17476_17476_4_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000376360_ARGLU1_chr13_107212005_ENST00000400198_length(amino acids)=178AA_BP=21
MALRLLRRAARGAAAAALLRLRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELA

--------------------------------------------------------------
>17476_17476_5_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000444838_ARGLU1_chr13_107212005_ENST00000400198_length(transcript)=2887nt_BP=89nt
AAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTT
CGACAGCAAGAAATAGAAGAAAAACTCATCGAGGAAGAAACAGCACGAAGAGTAGAAGAATTGGTAGCAAAAAGGGTGGAGGAAGAACTG
GAGAAAAGGAAGGATGAAATTGAACGAGAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGAACTC
GAGCGACAGAGACAAGCTGAGCTTGCCGCACAAAAAGCTAGAGAGGAGGAAGAACGTGCAAAACGTGAGGAGCTAGAGCGAATACTGGAA
GAGAATAACCGAAAAATTGCAGAAGCACAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGAGGAA
AGGATGAAACTAGAACAAGAACGACAACGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACTGTCC
TTCTCATTAAAAACCCAGGATTAAATTGCAAACTCTGAACTTTTTACAAAGAAAAATGGAAAAACTTTGTATGGTAGCTTCATGTTGAAG
TGGTTTTTTGTTTTTGTTTTTGTTTTTTTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCCCTTT
TTTTTTTTTTTTTTCCTTCCACTAAGTCAAATCCTTATCAGATCATTGTTGTATTCTAAGGAGTGACGTATTTTTCACCTGTTTGGATTC
TATATTAGTGGTCTGAGGAAGAGCAGATCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGAGTTA
TACTCTGTTTGCTACATCATAATGCTGGTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGCATTG
GGAAATTCCCAGGGTATTACTGGACCTATGTGGTGTATTGTTAAACCAGTGTCCTTGTGATACTGTTGCTCTTGATGTTCCTGATACAGG
TAAGGAAACAGTTGGTCAACTCTGATACAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAAAATC
AAACCAGCATTCCCCATTGTGTAAATAAATGATTTTGCTGAATAAAGTAAAGTCTTAAATTCATATGTTGAAGCAATTTTTTTTAATGTT
ATGTTAAGTCTTAAAGAGGGTGGTTCACTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTTTAAC
ATAGGGTTTATATGTACATTAAATATACTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCAAATG
GCATCAGTGTTACCTTTAAGAAAGACTAACAACATCCAGAAGATTTAAATTCTCAAACCTGTGCCTCTGTTTTAGGATATAAGTATTATC
ACAAAGTATACTTAATAAAGGCTAGAAAAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACTTAGC
TTTATACTGTCAAAAAAAGGCTAAGATGGTCGAGTCATTTTCATTGTGTAGTGTACTTGCACGTTTATTTTTAGGACAAACACATTTGAA
CTTTATGAATTTTTTTTTTTTTTTTGCATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTTAACA
TATGTTTAAGTATACTGGTATTAAAACATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAGTAGA
GAAAATATTTTTATTTTTGCCCAATATTTTTTAGACAGTTTGATTATTCTTAAAAATTGAAAACATAAGCTAAAGAGATGACTAAATGGT
AGATTATTTTGTGTGTGCATGCTAGGAAAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAATATAA
AATCAGTTTAAAGATCTTTAAAGGTAGAATTTTAAATAGGCATGAAATATAGTGAGAACTTTTAGTAAACATACTACTTACTCTAAAATC
AAACATTTTATTTTCCTAAAGAATATAGGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTTTTTT
TTTTTTCAATGTAACTTTTTTTGGTGAAGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGTTCTA
TACAAGTGTTCAAAACATTGTATCTAAAGAGAGTAGCCTGGACTTAAAATATTTGAAATCAGCTTATGCGTGCCTTTTAATTTTTTTTTT
AAGTTTCTTACTGCCACATATGGTGTGAAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCAGTGA
GATGTTGAAATTGTTCCTGTGCTTGGTAACTACTTTCCTCTGCCAGGCTATGGGAAAGAGGATGTAATTGTGAATAATATACACCATCCA
GTCTTTAATGTGCTGCAACAATGTAGTAATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTCCCCC
AGTCTATTAGAAGTTAAGATGTTCCCTAATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTATAGA
ATTAAGTATGACTTTGTTTATTTTTATTACAGTATGTAGTTATTGACATATTGTGGTTTGCAGAATTATCAATTGTATAAACTAAACCTT

>17476_17476_5_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000444838_ARGLU1_chr13_107212005_ENST00000400198_length(amino acids)=178AA_BP=21
MALRLLRRAARGAAAAALLRLRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CLYBL-ARGLU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CLYBL-ARGLU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CLYBL-ARGLU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource