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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DLG2-CBR1 (FusionGDB2 ID:HG1740TG873)

Fusion Gene Summary for DLG2-CBR1

check button Fusion gene summary
Fusion gene informationFusion gene name: DLG2-CBR1
Fusion gene ID: hg1740tg873
HgeneTgene
Gene symbol

DLG2

CBR1

Gene ID

1740

873

Gene namediscs large MAGUK scaffold protein 2carbonyl reductase 1
SynonymsPPP1R58|PSD-93|PSD93|chapsyn-110CBR|SDR21C1|hCBR1
Cytomap('DLG2')('CBR1')

11q14.1

21q22.12

Type of geneprotein-codingprotein-coding
Descriptiondisks large homolog 2DLG2 protein isoformchannel-associated protein of synapse-110channel-associated protein of synapses, 110kDadiscs, large homolog 2, chapsyn-110postsynaptic density protein PSD-93protein phosphatase 1, regulatory subunit 58carbonyl reductase [NADPH] 115-hydroxyprostaglandin dehydrogenaseNADPH-dependent carbonyl reductase 1carbonyl reductase (NADPH) 1epididymis secretory sperm binding proteinprostaglandin 9-ketoreductaseprostaglandin-E(2) 9-reductaseshort chain dehydr
Modification date2020031320200313
UniProtAcc

Q15700

.
Ensembl transtripts involved in fusion geneENST00000376104, ENST00000398309, 
ENST00000524982, ENST00000532653, 
ENST00000543673, ENST00000280241, 
ENST00000330014, ENST00000376106, 
ENST00000398301, ENST00000398304, 
ENST00000404783, ENST00000418306, 
ENST00000426717, ENST00000472545, 
ENST00000530800, ENST00000531015, 
ENST00000537455, 
Fusion gene scores* DoF score22 X 25 X 7=38504 X 4 X 3=48
# samples 234
** MAII scorelog2(23/3850*10)=-4.06515267952525
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DLG2 [Title/Abstract] AND CBR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDLG2(84245613)-CBR1(37443248), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDLG2

GO:0010923

negative regulation of phosphatase activity

19389623

TgeneCBR1

GO:0017144

drug metabolic process

18449627

TgeneCBR1

GO:0042373

vitamin K metabolic process

18449627

TgeneCBR1

GO:0055114

oxidation-reduction process

19442656



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-32-2616-01ADLG2chr11

84245613

-CBR1chr21

37443248

+


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Fusion Gene ORF analysis for DLG2-CBR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000376104ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000376104ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000376104ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000376104ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000376104ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000398309ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000398309ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000398309ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000398309ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000398309ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000524982ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000524982ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000524982ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000524982ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000524982ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000532653ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000532653ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000532653ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000532653ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000532653ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000543673ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000543673ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000543673ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000543673ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
5CDS-3UTRENST00000543673ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000280241ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000280241ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000280241ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000280241ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000280241ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000330014ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000330014ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000330014ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000330014ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000330014ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000376106ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000376106ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000376106ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000376106ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000376106ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000398301ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000398301ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000398301ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000398301ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000398301ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000398304ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000398304ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000398304ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000398304ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000398304ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000404783ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000404783ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000404783ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000404783ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000404783ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000418306ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000418306ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000418306ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000418306ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000418306ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000426717ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000426717ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000426717ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000426717ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000426717ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000472545ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000472545ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000472545ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000472545ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000472545ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000530800ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000530800ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000530800ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000530800ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000530800ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000531015ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000531015ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000531015ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000531015ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000531015ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000537455ENST00000290349DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000537455ENST00000399191DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000537455ENST00000439427DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000537455ENST00000466328DLG2chr11

84245613

-CBR1chr21

37443248

+
intron-3UTRENST00000537455ENST00000530908DLG2chr11

84245613

-CBR1chr21

37443248

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DLG2-CBR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DLG2chr1184245612-CBR1chr2137443247+0.132848780.8671512
DLG2chr1184245612-CBR1chr2137443247+0.132848780.8671512


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DLG2-CBR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:84245613/:37443248)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLG2

Q15700

.
FUNCTION: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DLG2-CBR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DLG2-CBR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DLG2-CBR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DLG2-CBR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDLG2C0036341Schizophrenia4PSYGENET
HgeneDLG2C0005586Bipolar Disorder2PSYGENET
HgeneDLG2C0025202melanoma1CTD_human
HgeneDLG2C0041696Unipolar Depression1PSYGENET
HgeneDLG2C0809983Schizophrenia and related disorders1PSYGENET
HgeneDLG2C1269683Major Depressive Disorder1PSYGENET
TgeneC0007102Malignant tumor of colon1CTD_human
TgeneC0009375Colonic Neoplasms1CTD_human
TgeneC0022661Kidney Failure, Chronic1CTD_human
TgeneC0033141Cardiomyopathies, Primary1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0036529Myocardial Diseases, Secondary1CTD_human
TgeneC0162823Dermatitis, Irritant1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0878544Cardiomyopathies1CTD_human
TgeneC2239176Liver carcinoma1CTD_human