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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNM2-CNN1 (FusionGDB2 ID:HG1785TG1264)

Fusion Gene Summary for DNM2-CNN1

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM2-CNN1
Fusion gene ID: hg1785tg1264
HgeneTgene
Gene symbol

DNM2

CNN1

Gene ID

1785

1264

Gene namedynamin 2calponin 1
SynonymsCMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5HEL-S-14|SMCC|Sm-Calp
Cytomap('DNM2')('CNN1')

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptiondynamin-2dynamin IIcalponin-1basic calponincalponin 1, basic, smooth musclecalponin H1, smooth musclecalponins, basicepididymis secretory protein Li 14
Modification date2020032920200313
UniProtAcc.

P51911

Ensembl transtripts involved in fusion geneENST00000314646, ENST00000355667, 
ENST00000359692, ENST00000389253, 
ENST00000408974, ENST00000585892, 
ENST00000591819, 
Fusion gene scores* DoF score36 X 17 X 17=104044 X 3 X 3=36
# samples 495
** MAII scorelog2(49/10404*10)=-4.40821274494042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DNM2 [Title/Abstract] AND CNN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNM2(10934575)-CNN1(11649701), # samples:1
DNM2(10934575)-CNN1(11651891), # samples:1
Anticipated loss of major functional domain due to fusion event.DNM2-CNN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-CNN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-CNN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-CNN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313


check buttonFusion gene breakpoints across DNM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CNN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-3666-01ADNM2chr19

10934575

+CNN1chr19

11649701

+
ChimerDB4COADTCGA-AA-3666-01ADNM2chr19

10934575

+CNN1chr19

11651891

+


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Fusion Gene ORF analysis for DNM2-CNN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000314646ENST00000544952DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-3UTRENST00000314646ENST00000588468DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-3UTRENST00000314646ENST00000588468DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-3UTRENST00000355667ENST00000544952DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-3UTRENST00000355667ENST00000588468DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-3UTRENST00000355667ENST00000588468DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-3UTRENST00000359692ENST00000544952DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-3UTRENST00000359692ENST00000588468DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-3UTRENST00000359692ENST00000588468DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-3UTRENST00000389253ENST00000544952DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-3UTRENST00000389253ENST00000588468DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-3UTRENST00000389253ENST00000588468DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-3UTRENST00000408974ENST00000544952DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-3UTRENST00000408974ENST00000588468DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-3UTRENST00000408974ENST00000588468DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-3UTRENST00000585892ENST00000544952DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-3UTRENST00000585892ENST00000588468DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-3UTRENST00000585892ENST00000588468DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-5UTRENST00000314646ENST00000252456DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000314646ENST00000535659DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000314646ENST00000535659DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-5UTRENST00000314646ENST00000592923DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000314646ENST00000592923DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-5UTRENST00000355667ENST00000252456DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000355667ENST00000535659DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000355667ENST00000535659DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-5UTRENST00000355667ENST00000592923DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000355667ENST00000592923DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-5UTRENST00000359692ENST00000252456DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000359692ENST00000535659DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000359692ENST00000535659DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-5UTRENST00000359692ENST00000592923DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000359692ENST00000592923DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-5UTRENST00000389253ENST00000252456DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000389253ENST00000535659DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000389253ENST00000535659DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-5UTRENST00000389253ENST00000592923DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000389253ENST00000592923DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-5UTRENST00000408974ENST00000252456DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000408974ENST00000535659DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000408974ENST00000535659DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-5UTRENST00000408974ENST00000592923DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000408974ENST00000592923DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-5UTRENST00000585892ENST00000252456DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000585892ENST00000535659DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000585892ENST00000535659DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-5UTRENST00000585892ENST00000592923DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-5UTRENST00000585892ENST00000592923DNM2chr19

10934575

+CNN1chr19

11651891

+
5CDS-intronENST00000314646ENST00000544952DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-intronENST00000355667ENST00000544952DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-intronENST00000359692ENST00000544952DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-intronENST00000389253ENST00000544952DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-intronENST00000408974ENST00000544952DNM2chr19

10934575

+CNN1chr19

11649701

+
5CDS-intronENST00000585892ENST00000544952DNM2chr19

10934575

+CNN1chr19

11649701

+
In-frameENST00000314646ENST00000252456DNM2chr19

10934575

+CNN1chr19

11651891

+
In-frameENST00000355667ENST00000252456DNM2chr19

10934575

+CNN1chr19

11651891

+
In-frameENST00000359692ENST00000252456DNM2chr19

10934575

+CNN1chr19

11651891

+
In-frameENST00000389253ENST00000252456DNM2chr19

10934575

+CNN1chr19

11651891

+
In-frameENST00000408974ENST00000252456DNM2chr19

10934575

+CNN1chr19

11651891

+
In-frameENST00000585892ENST00000252456DNM2chr19

10934575

+CNN1chr19

11651891

+
intron-3CDSENST00000591819ENST00000252456DNM2chr19

10934575

+CNN1chr19

11651891

+
intron-3UTRENST00000591819ENST00000544952DNM2chr19

10934575

+CNN1chr19

11651891

+
intron-3UTRENST00000591819ENST00000588468DNM2chr19

10934575

+CNN1chr19

11649701

+
intron-3UTRENST00000591819ENST00000588468DNM2chr19

10934575

+CNN1chr19

11651891

+
intron-5UTRENST00000591819ENST00000252456DNM2chr19

10934575

+CNN1chr19

11649701

+
intron-5UTRENST00000591819ENST00000535659DNM2chr19

10934575

+CNN1chr19

11649701

+
intron-5UTRENST00000591819ENST00000535659DNM2chr19

10934575

+CNN1chr19

11651891

+
intron-5UTRENST00000591819ENST00000592923DNM2chr19

10934575

+CNN1chr19

11649701

+
intron-5UTRENST00000591819ENST00000592923DNM2chr19

10934575

+CNN1chr19

11651891

+
intron-intronENST00000591819ENST00000544952DNM2chr19

10934575

+CNN1chr19

11649701

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000585892DNM2chr1910934575+ENST00000252456CNN1chr1911651891+341620571642887907
ENST00000314646DNM2chr1910934575+ENST00000252456CNN1chr1911651891+341620571642887907
ENST00000359692DNM2chr1910934575+ENST00000252456CNN1chr1911651891+339020311502861903
ENST00000389253DNM2chr1910934575+ENST00000252456CNN1chr1911651891+336420051122835907
ENST00000355667DNM2chr1910934575+ENST00000252456CNN1chr1911651891+33321973802803907
ENST00000408974DNM2chr1910934575+ENST00000252456CNN1chr1911651891+32751916352746903

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585892ENST00000252456DNM2chr1910934575+CNN1chr1911651891+0.011517120.9884829
ENST00000314646ENST00000252456DNM2chr1910934575+CNN1chr1911651891+0.0113775860.9886225
ENST00000359692ENST00000252456DNM2chr1910934575+CNN1chr1911651891+0.0113377760.9886622
ENST00000389253ENST00000252456DNM2chr1910934575+CNN1chr1911651891+0.010865220.9891348
ENST00000355667ENST00000252456DNM2chr1910934575+CNN1chr1911651891+0.0112599780.98874
ENST00000408974ENST00000252456DNM2chr1910934575+CNN1chr1911651891+0.0115597020.9884403

Top

Fusion Genomic Features for DNM2-CNN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DNM2chr1910934575+CNN1chr1911651890+3.72E-091
DNM2chr1910934575+CNN1chr1911651890+3.72E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for DNM2-CNN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10934575/chr19:11649701)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CNN1

P51911

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10934575chr19:11651891ENST00000355667+172128_294631871.0DomainDynamin-type G
HgeneDNM2chr19:10934575chr19:11651891ENST00000355667+1721519_625631871.0DomainPH
HgeneDNM2chr19:10934575chr19:11651891ENST00000359692+162028_294627867.0DomainDynamin-type G
HgeneDNM2chr19:10934575chr19:11651891ENST00000359692+1620519_625627867.0DomainPH
HgeneDNM2chr19:10934575chr19:11651891ENST00000389253+172128_294631871.0DomainDynamin-type G
HgeneDNM2chr19:10934575chr19:11651891ENST00000389253+1721519_625631871.0DomainPH
HgeneDNM2chr19:10934575chr19:11651891ENST00000408974+162028_294627867.0DomainDynamin-type G
HgeneDNM2chr19:10934575chr19:11651891ENST00000408974+1620519_625627867.0DomainPH
HgeneDNM2chr19:10934575chr19:11651891ENST00000585892+172128_294631870.0DomainDynamin-type G
HgeneDNM2chr19:10934575chr19:11651891ENST00000585892+1721519_625631870.0DomainPH
HgeneDNM2chr19:10934575chr19:11651891ENST00000355667+1721205_211631871.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000355667+1721236_239631871.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000355667+172138_46631871.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000359692+1620205_211627867.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000359692+1620236_239627867.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000359692+162038_46627867.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000389253+1721205_211631871.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000389253+1721236_239631871.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000389253+172138_46631871.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000408974+1620205_211627867.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000408974+1620236_239627867.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000408974+162038_46627867.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000585892+1721205_211631870.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000585892+1721236_239631870.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000585892+172138_46631870.0Nucleotide bindingGTP
HgeneDNM2chr19:10934575chr19:11651891ENST00000355667+1721136_139631871.0RegionG3 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000355667+1721205_208631871.0RegionG4 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000355667+1721235_238631871.0RegionG5 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000355667+172138_45631871.0RegionG1 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000355667+172164_66631871.0RegionG2 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000359692+1620136_139627867.0RegionG3 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000359692+1620205_208627867.0RegionG4 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000359692+1620235_238627867.0RegionG5 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000359692+162038_45627867.0RegionG1 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000359692+162064_66627867.0RegionG2 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000389253+1721136_139631871.0RegionG3 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000389253+1721205_208631871.0RegionG4 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000389253+1721235_238631871.0RegionG5 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000389253+172138_45631871.0RegionG1 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000389253+172164_66631871.0RegionG2 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000408974+1620136_139627867.0RegionG3 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000408974+1620205_208627867.0RegionG4 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000408974+1620235_238627867.0RegionG5 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000408974+162038_45627867.0RegionG1 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000408974+162064_66627867.0RegionG2 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000585892+1721136_139631870.0RegionG3 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000585892+1721205_208631870.0RegionG4 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000585892+1721235_238631870.0RegionG5 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000585892+172138_45631870.0RegionG1 motif
HgeneDNM2chr19:10934575chr19:11651891ENST00000585892+172164_66631870.0RegionG2 motif
TgeneCNN1chr19:10934575chr19:11651891ENST000002524560728_13121298.0DomainCalponin-homology (CH)
TgeneCNN1chr19:10934575chr19:11651891ENST0000025245607164_18921298.0RepeatNote=Calponin-like 1
TgeneCNN1chr19:10934575chr19:11651891ENST0000025245607204_22921298.0RepeatNote=Calponin-like 2
TgeneCNN1chr19:10934575chr19:11651891ENST0000025245607243_26821298.0RepeatNote=Calponin-like 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10934575chr19:11651891ENST00000355667+1721747_866631871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10934575chr19:11651891ENST00000359692+1620747_866627867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10934575chr19:11651891ENST00000389253+1721747_866631871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10934575chr19:11651891ENST00000408974+1620747_866627867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10934575chr19:11651891ENST00000585892+1721747_866631870.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10934575chr19:11651891ENST00000355667+1721653_744631871.0DomainGED
HgeneDNM2chr19:10934575chr19:11651891ENST00000359692+1620653_744627867.0DomainGED
HgeneDNM2chr19:10934575chr19:11651891ENST00000389253+1721653_744631871.0DomainGED
HgeneDNM2chr19:10934575chr19:11651891ENST00000408974+1620653_744627867.0DomainGED
HgeneDNM2chr19:10934575chr19:11651891ENST00000585892+1721653_744631870.0DomainGED


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Fusion Gene Sequence for DNM2-CNN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23639_23639_1_DNM2-CNN1_DNM2_chr19_10934575_ENST00000314646_CNN1_chr19_11651891_ENST00000252456_length(transcript)=3416nt_BP=2057nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGACTTCCTTCCCCGCGGTTCAGGAATCGTCACCC
GGCGGCCTCTCATTCTGCAGCTCATCTTCTCAAAAACAGAACATGCCGAGTTTTTGCACTGCAAGTCCAAAAAGTTTACAGACTTTGATG
AAGTCCGGCAGGAGATTGAAGCAGAGACCGACAGGGTCACGGGGACCAACAAAGGCATCTCCCCAGTGCCCATCAACCTTCGAGTCTACT
CGCCACACGTGTTGAACTTGACCCTCATCGACCTCCCGGGTATCACCAAGGTGCCTGTGGGCGACCAGCCTCCAGACATCGAGTACCAGA
TCAAGGACATGATCCTGCAGTTCATCAGCCGGGAGAGCAGCCTCATTCTGGCTGTCACGCCCGCCAACATGGACCTGGCCAACTCCGACG
CCCTCAAGCTGGCCAAGGAAGTCGATCCCCAAGGCCTACGGACCATCGGTGTCATCACCAAGCTTGACCTGATGGACGAGGGCACCGACG
CCAGGGACGTCTTGGAGAACAAGTTGCTCCCGTTGAGAAGAGGCTACATTGGCGTGGTGAACCGCAGCCAGAAGGATATTGAGGGCAAGA
AGGACATCCGTGCAGCACTGGCAGCTGAGAGGAAGTTCTTCCTCTCCCACCCGGCCTACCGGCACATGGCCGACCGCATGGGCACGCCAC
ATCTGCAGAAGACGCTGAATCAGCAACTGACCAACCACATCCGGGAGTCGCTGCCGGCCCTACGTAGCAAACTACAGAGCCAGCTGCTGT
CCCTGGAGAAGGAGGTGGAGGAGTACAAGAACTTTCGGCCCGACGACCCCACCCGCAAAACCAAAGCCCTGCTGCAGATGGTCCAGCAGT
TTGGGGTGGATTTTGAGAAGAGGATCGAGGGCTCAGGAGATCAGGTGGACACTCTGGAGCTCTCCGGGGGCGCCCGAATCAATCGCATCT
TCCACGAGCGGTTCCCATTTGAGCTGGTGAAGATGGAGTTTGACGAGAAGGACTTACGACGGGAGATCAGCTATGCCATTAAGAACATCC
ATGGAGTCAGGACGGGGCTCTTCACCCCCGACATGGCCTTTGAAGCCATTGTGAAAAAACAGATTGTAAAACTCAAAGAGCCGAGTTTGA
AGTGTGTTGATCTCGTGGTCTCAGAGCTGGCCACGGTCATAAAAAAGTGTGCCGAGAAGCTCAGTTCCTACCCCCGGTTGCGAGAGGAGA
CAGAGCGAATCGTCACCACTTACATCCGGGAACGGGAGGGGAGAACGAAGGACCAGATTCTTCTGCTGATCGACATTGAGCAGTCCTACA
TCAACACGAACCATGAGGACTTCATCGGGTTTGCCAATGCCCAGCAGAGGAGCACGCAGCTGAACAAGAAGAGAGCCATCCCCAATCAGC
CTGAAACCCTGGTGATCCGCAGGGGCTGGCTGACCATCAACAACATCAGCCTGATGAAAGGCGGCTCCAAGGAGTACTGGTTTGTGCTGA
CTGCCGAGTCACTGTCCTGGTACAAGGATGAGGAGGAGAAAGAGAAGAAGTACATGCTGCCTCTGGACAACCTCAAGATCCGTGATGTGG
AGAAGGGCTTCATGTCCAACAAGCACGTCTTCGCCATCTTCAACACGGAGCAGAGAAACGTCTACAAGGACCTGCGGCAGATCGAGCTGG
CCTGTGACTCCCAGGAAGACGTGGACAGCTGGAAGGCCTCGTTCCTCCGAGCTGGCGTCTACCCCGAGAAGGACCAGCTGGCCCAGAAGT
ATGACCACCAGCGGGAGCAGGAGCTGAGAGAGTGGATCGAGGGGGTGACAGGCCGTCGCATCGGCAACAACTTCATGGACGGCCTCAAAG
ATGGCATCATTCTTTGCGAATTCATCAATAAGCTGCAGCCAGGCTCCGTGAAGAAGATCAATGAGTCAACCCAAAATTGGCACCAGCTGG
AGAACATCGGCAACTTCATCAAGGCCATCACCAAGTATGGGGTGAAGCCCCACGACATTTTTGAGGCCAACGACCTGTTTGAGAACACCA
ACCATACACAGGTGCAGTCCACCCTCCTGGCTTTGGCCAGCATGGCGAAGACGAAAGGAAACAAGGTGAACGTGGGAGTGAAGTACGCAG
AGAAGCAGGAGCGGAAATTCGAGCCGGGGAAGCTAAGAGAAGGGCGGAACATCATTGGGCTGCAGATGGGCACCAACAAGTTTGCCAGCC
AGCAGGGCATGACGGCCTATGGCACCCGGCGCCACCTCTACGACCCCAAGCTGGGCACAGACCAGCCTCTGGACCAGGCGACCATCAGCC
TGCAGATGGGCACCAACAAAGGAGCCAGCCAGGCTGGCATGACTGCGCCAGGGACCAAGCGGCAGATCTTCGAGCCGGGGCTGGGCATGG
AGCACTGCGACACGCTCAATGTCAGCCTGCAGATGGGCAGCAACAAGGGCGCCTCGCAGCGGGGCATGACGGTGTATGGGCTGCCACGCC
AGGTCTACGACCCCAAGTACTGTCTGACTCCCGAGTACCCAGAGCTGGGTGAGCCCGCCCACAACCACCACGCACACAACTACTACAATT
CCGCCTAGGGCCACAAGGCCTTCCCTGTTTTCCCCCCAAGGGAGGCTGCTGCTGCTCTTGGCTGGACCCAGCCAGGCCCAGCCGACCCCC
TCTCCCTGCATGGCATCCTCCAGCCCCTGTAGAACTCAACCTCTACAGGGTTAGAGTTTGGAGAGAGCAGACTGGCGGGGGGCCCATTGG
GGGGAAGGGGACCCTCCGCTCTGTAGTGCTACAGGGTCCAACATAGAGCCGGGTGTCCCCAACAGCGCCCAAAGGACGCACTGAGCAACG
CTATTCCAGCTGTCCCCCCACTCCCTCACAAGTGGGTACCCCCAGGACCAGAAGCTCCCCCAGCAAAGCCCCCAGAGCCCAGGCTCGGCC
TGCCCCCACCCCATTCCCGCAGTGGGAGCAAACTGCATGCCCAGAGACCCAGCGGACACACGCGGTTTGGTTTGCAGCGACTGGCATACT
ATGTGGATGTGACAGTGGCGTTTGTAATGAGAGCACTTTCTTTTTTTTCTATTTCACTGGAGCACAATAAATGGCTGTAAAATCTC

>23639_23639_1_DNM2-CNN1_DNM2_chr19_10934575_ENST00000314646_CNN1_chr19_11651891_ENST00000252456_length(amino acids)=907AA_BP=396
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQPETLVIRRGWLTINNISLMKGGSKE
YWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKD
QLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEAND
LFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLD
QATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHA
HNYYNSA

--------------------------------------------------------------
>23639_23639_2_DNM2-CNN1_DNM2_chr19_10934575_ENST00000355667_CNN1_chr19_11651891_ENST00000252456_length(transcript)=3332nt_BP=1973nt
CAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACC
GCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGA
TCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGACTTCCTTCCCCGCGGTTCAGGAATCG
TCACCCGGCGGCCTCTCATTCTGCAGCTCATCTTCTCAAAAACAGAACATGCCGAGTTTTTGCACTGCAAGTCCAAAAAGTTTACAGACT
TTGATGAAGTCCGGCAGGAGATTGAAGCAGAGACCGACAGGGTCACGGGGACCAACAAAGGCATCTCCCCAGTGCCCATCAACCTTCGAG
TCTACTCGCCACACGTGTTGAACTTGACCCTCATCGACCTCCCGGGTATCACCAAGGTGCCTGTGGGCGACCAGCCTCCAGACATCGAGT
ACCAGATCAAGGACATGATCCTGCAGTTCATCAGCCGGGAGAGCAGCCTCATTCTGGCTGTCACGCCCGCCAACATGGACCTGGCCAACT
CCGACGCCCTCAAGCTGGCCAAGGAAGTCGATCCCCAAGGCCTACGGACCATCGGTGTCATCACCAAGCTTGACCTGATGGACGAGGGCA
CCGACGCCAGGGACGTCTTGGAGAACAAGTTGCTCCCGTTGAGAAGAGGCTACATTGGCGTGGTGAACCGCAGCCAGAAGGATATTGAGG
GCAAGAAGGACATCCGTGCAGCACTGGCAGCTGAGAGGAAGTTCTTCCTCTCCCACCCGGCCTACCGGCACATGGCCGACCGCATGGGCA
CGCCACATCTGCAGAAGACGCTGAATCAGCAACTGACCAACCACATCCGGGAGTCGCTGCCGGCCCTACGTAGCAAACTACAGAGCCAGC
TGCTGTCCCTGGAGAAGGAGGTGGAGGAGTACAAGAACTTTCGGCCCGACGACCCCACCCGCAAAACCAAAGCCCTGCTGCAGATGGTCC
AGCAGTTTGGGGTGGATTTTGAGAAGAGGATCGAGGGCTCAGGAGATCAGGTGGACACTCTGGAGCTCTCCGGGGGCGCCCGAATCAATC
GCATCTTCCACGAGCGGTTCCCATTTGAGCTGGTGAAGATGGAGTTTGACGAGAAGGACTTACGACGGGAGATCAGCTATGCCATTAAGA
ACATCCATGGAGTCAGGACCGGGCTTTTCACCCCGGACTTGGCATTCGAGGCCATTGTGAAAAAGCAGGTCGTCAAGCTGAAAGAGCCCT
GTCTGAAATGTGTCGACCTGGTTATCCAGGAGCTAATCAATACAGTTAGGCAGTGTACCAGTAAGCTCAGTTCCTACCCCCGGTTGCGAG
AGGAGACAGAGCGAATCGTCACCACTTACATCCGGGAACGGGAGGGGAGAACGAAGGACCAGATTCTTCTGCTGATCGACATTGAGCAGT
CCTACATCAACACGAACCATGAGGACTTCATCGGGTTTGCCAATGCCCAGCAGAGGAGCACGCAGCTGAACAAGAAGAGAGCCATCCCCA
ATCAGGGGGAGATCCTGGTGATCCGCAGGGGCTGGCTGACCATCAACAACATCAGCCTGATGAAAGGCGGCTCCAAGGAGTACTGGTTTG
TGCTGACTGCCGAGTCACTGTCCTGGTACAAGGATGAGGAGGAGAAAGAGAAGAAGTACATGCTGCCTCTGGACAACCTCAAGATCCGTG
ATGTGGAGAAGGGCTTCATGTCCAACAAGCACGTCTTCGCCATCTTCAACACGGAGCAGAGAAACGTCTACAAGGACCTGCGGCAGATCG
AGCTGGCCTGTGACTCCCAGGAAGACGTGGACAGCTGGAAGGCCTCGTTCCTCCGAGCTGGCGTCTACCCCGAGAAGGACCAGCTGGCCC
AGAAGTATGACCACCAGCGGGAGCAGGAGCTGAGAGAGTGGATCGAGGGGGTGACAGGCCGTCGCATCGGCAACAACTTCATGGACGGCC
TCAAAGATGGCATCATTCTTTGCGAATTCATCAATAAGCTGCAGCCAGGCTCCGTGAAGAAGATCAATGAGTCAACCCAAAATTGGCACC
AGCTGGAGAACATCGGCAACTTCATCAAGGCCATCACCAAGTATGGGGTGAAGCCCCACGACATTTTTGAGGCCAACGACCTGTTTGAGA
ACACCAACCATACACAGGTGCAGTCCACCCTCCTGGCTTTGGCCAGCATGGCGAAGACGAAAGGAAACAAGGTGAACGTGGGAGTGAAGT
ACGCAGAGAAGCAGGAGCGGAAATTCGAGCCGGGGAAGCTAAGAGAAGGGCGGAACATCATTGGGCTGCAGATGGGCACCAACAAGTTTG
CCAGCCAGCAGGGCATGACGGCCTATGGCACCCGGCGCCACCTCTACGACCCCAAGCTGGGCACAGACCAGCCTCTGGACCAGGCGACCA
TCAGCCTGCAGATGGGCACCAACAAAGGAGCCAGCCAGGCTGGCATGACTGCGCCAGGGACCAAGCGGCAGATCTTCGAGCCGGGGCTGG
GCATGGAGCACTGCGACACGCTCAATGTCAGCCTGCAGATGGGCAGCAACAAGGGCGCCTCGCAGCGGGGCATGACGGTGTATGGGCTGC
CACGCCAGGTCTACGACCCCAAGTACTGTCTGACTCCCGAGTACCCAGAGCTGGGTGAGCCCGCCCACAACCACCACGCACACAACTACT
ACAATTCCGCCTAGGGCCACAAGGCCTTCCCTGTTTTCCCCCCAAGGGAGGCTGCTGCTGCTCTTGGCTGGACCCAGCCAGGCCCAGCCG
ACCCCCTCTCCCTGCATGGCATCCTCCAGCCCCTGTAGAACTCAACCTCTACAGGGTTAGAGTTTGGAGAGAGCAGACTGGCGGGGGGCC
CATTGGGGGGAAGGGGACCCTCCGCTCTGTAGTGCTACAGGGTCCAACATAGAGCCGGGTGTCCCCAACAGCGCCCAAAGGACGCACTGA
GCAACGCTATTCCAGCTGTCCCCCCACTCCCTCACAAGTGGGTACCCCCAGGACCAGAAGCTCCCCCAGCAAAGCCCCCAGAGCCCAGGC
TCGGCCTGCCCCCACCCCATTCCCGCAGTGGGAGCAAACTGCATGCCCAGAGACCCAGCGGACACACGCGGTTTGGTTTGCAGCGACTGG
CATACTATGTGGATGTGACAGTGGCGTTTGTAATGAGAGCACTTTCTTTTTTTTCTATTTCACTGGAGCACAATAAATGGCTGTAAAATC
TC

>23639_23639_2_DNM2-CNN1_DNM2_chr19_10934575_ENST00000355667_CNN1_chr19_11651891_ENST00000252456_length(amino acids)=907AA_BP=398
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKE
YWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKD
QLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEAND
LFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLD
QATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHA
HNYYNSA

--------------------------------------------------------------
>23639_23639_3_DNM2-CNN1_DNM2_chr19_10934575_ENST00000359692_CNN1_chr19_11651891_ENST00000252456_length(transcript)=3390nt_BP=2031nt
GCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGT
CGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATC
CCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAG
AGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGACTTCCTTCCCCGCGGTTCAGGAATCGTCACCCGGCGGCCTCTCATT
CTGCAGCTCATCTTCTCAAAAACAGAACATGCCGAGTTTTTGCACTGCAAGTCCAAAAAGTTTACAGACTTTGATGAAGTCCGGCAGGAG
ATTGAAGCAGAGACCGACAGGGTCACGGGGACCAACAAAGGCATCTCCCCAGTGCCCATCAACCTTCGAGTCTACTCGCCACACGTGTTG
AACTTGACCCTCATCGACCTCCCGGGTATCACCAAGGTGCCTGTGGGCGACCAGCCTCCAGACATCGAGTACCAGATCAAGGACATGATC
CTGCAGTTCATCAGCCGGGAGAGCAGCCTCATTCTGGCTGTCACGCCCGCCAACATGGACCTGGCCAACTCCGACGCCCTCAAGCTGGCC
AAGGAAGTCGATCCCCAAGGCCTACGGACCATCGGTGTCATCACCAAGCTTGACCTGATGGACGAGGGCACCGACGCCAGGGACGTCTTG
GAGAACAAGTTGCTCCCGTTGAGAAGAGGCTACATTGGCGTGGTGAACCGCAGCCAGAAGGATATTGAGGGCAAGAAGGACATCCGTGCA
GCACTGGCAGCTGAGAGGAAGTTCTTCCTCTCCCACCCGGCCTACCGGCACATGGCCGACCGCATGGGCACGCCACATCTGCAGAAGACG
CTGAATCAGCAACTGACCAACCACATCCGGGAGTCGCTGCCGGCCCTACGTAGCAAACTACAGAGCCAGCTGCTGTCCCTGGAGAAGGAG
GTGGAGGAGTACAAGAACTTTCGGCCCGACGACCCCACCCGCAAAACCAAAGCCCTGCTGCAGATGGTCCAGCAGTTTGGGGTGGATTTT
GAGAAGAGGATCGAGGGCTCAGGAGATCAGGTGGACACTCTGGAGCTCTCCGGGGGCGCCCGAATCAATCGCATCTTCCACGAGCGGTTC
CCATTTGAGCTGGTGAAGATGGAGTTTGACGAGAAGGACTTACGACGGGAGATCAGCTATGCCATTAAGAACATCCATGGAGTCAGGACC
GGGCTTTTCACCCCGGACTTGGCATTCGAGGCCATTGTGAAAAAGCAGGTCGTCAAGCTGAAAGAGCCCTGTCTGAAATGTGTCGACCTG
GTTATCCAGGAGCTAATCAATACAGTTAGGCAGTGTACCAGTAAGCTCAGTTCCTACCCCCGGTTGCGAGAGGAGACAGAGCGAATCGTC
ACCACTTACATCCGGGAACGGGAGGGGAGAACGAAGGACCAGATTCTTCTGCTGATCGACATTGAGCAGTCCTACATCAACACGAACCAT
GAGGACTTCATCGGGTTTGCCAATGCCCAGCAGAGGAGCACGCAGCTGAACAAGAAGAGAGCCATCCCCAATCAGGTGATCCGCAGGGGC
TGGCTGACCATCAACAACATCAGCCTGATGAAAGGCGGCTCCAAGGAGTACTGGTTTGTGCTGACTGCCGAGTCACTGTCCTGGTACAAG
GATGAGGAGGAGAAAGAGAAGAAGTACATGCTGCCTCTGGACAACCTCAAGATCCGTGATGTGGAGAAGGGCTTCATGTCCAACAAGCAC
GTCTTCGCCATCTTCAACACGGAGCAGAGAAACGTCTACAAGGACCTGCGGCAGATCGAGCTGGCCTGTGACTCCCAGGAAGACGTGGAC
AGCTGGAAGGCCTCGTTCCTCCGAGCTGGCGTCTACCCCGAGAAGGACCAGCTGGCCCAGAAGTATGACCACCAGCGGGAGCAGGAGCTG
AGAGAGTGGATCGAGGGGGTGACAGGCCGTCGCATCGGCAACAACTTCATGGACGGCCTCAAAGATGGCATCATTCTTTGCGAATTCATC
AATAAGCTGCAGCCAGGCTCCGTGAAGAAGATCAATGAGTCAACCCAAAATTGGCACCAGCTGGAGAACATCGGCAACTTCATCAAGGCC
ATCACCAAGTATGGGGTGAAGCCCCACGACATTTTTGAGGCCAACGACCTGTTTGAGAACACCAACCATACACAGGTGCAGTCCACCCTC
CTGGCTTTGGCCAGCATGGCGAAGACGAAAGGAAACAAGGTGAACGTGGGAGTGAAGTACGCAGAGAAGCAGGAGCGGAAATTCGAGCCG
GGGAAGCTAAGAGAAGGGCGGAACATCATTGGGCTGCAGATGGGCACCAACAAGTTTGCCAGCCAGCAGGGCATGACGGCCTATGGCACC
CGGCGCCACCTCTACGACCCCAAGCTGGGCACAGACCAGCCTCTGGACCAGGCGACCATCAGCCTGCAGATGGGCACCAACAAAGGAGCC
AGCCAGGCTGGCATGACTGCGCCAGGGACCAAGCGGCAGATCTTCGAGCCGGGGCTGGGCATGGAGCACTGCGACACGCTCAATGTCAGC
CTGCAGATGGGCAGCAACAAGGGCGCCTCGCAGCGGGGCATGACGGTGTATGGGCTGCCACGCCAGGTCTACGACCCCAAGTACTGTCTG
ACTCCCGAGTACCCAGAGCTGGGTGAGCCCGCCCACAACCACCACGCACACAACTACTACAATTCCGCCTAGGGCCACAAGGCCTTCCCT
GTTTTCCCCCCAAGGGAGGCTGCTGCTGCTCTTGGCTGGACCCAGCCAGGCCCAGCCGACCCCCTCTCCCTGCATGGCATCCTCCAGCCC
CTGTAGAACTCAACCTCTACAGGGTTAGAGTTTGGAGAGAGCAGACTGGCGGGGGGCCCATTGGGGGGAAGGGGACCCTCCGCTCTGTAG
TGCTACAGGGTCCAACATAGAGCCGGGTGTCCCCAACAGCGCCCAAAGGACGCACTGAGCAACGCTATTCCAGCTGTCCCCCCACTCCCT
CACAAGTGGGTACCCCCAGGACCAGAAGCTCCCCCAGCAAAGCCCCCAGAGCCCAGGCTCGGCCTGCCCCCACCCCATTCCCGCAGTGGG
AGCAAACTGCATGCCCAGAGACCCAGCGGACACACGCGGTTTGGTTTGCAGCGACTGGCATACTATGTGGATGTGACAGTGGCGTTTGTA
ATGAGAGCACTTTCTTTTTTTTCTATTTCACTGGAGCACAATAAATGGCTGTAAAATCTC

>23639_23639_3_DNM2-CNN1_DNM2_chr19_10934575_ENST00000359692_CNN1_chr19_11651891_ENST00000252456_length(amino acids)=903AA_BP=398
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQVIRRGWLTINNISLMKGGSKEYWFV
LTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQLAQ
KYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFEN
TNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATI
SLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHAHNYY
NSA

--------------------------------------------------------------
>23639_23639_4_DNM2-CNN1_DNM2_chr19_10934575_ENST00000389253_CNN1_chr19_11651891_ENST00000252456_length(transcript)=3364nt_BP=2005nt
CCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCT
CGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCAT
CGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGG
CCGGGACTTCCTTCCCCGCGGTTCAGGAATCGTCACCCGGCGGCCTCTCATTCTGCAGCTCATCTTCTCAAAAACAGAACATGCCGAGTT
TTTGCACTGCAAGTCCAAAAAGTTTACAGACTTTGATGAAGTCCGGCAGGAGATTGAAGCAGAGACCGACAGGGTCACGGGGACCAACAA
AGGCATCTCCCCAGTGCCCATCAACCTTCGAGTCTACTCGCCACACGTGTTGAACTTGACCCTCATCGACCTCCCGGGTATCACCAAGGT
GCCTGTGGGCGACCAGCCTCCAGACATCGAGTACCAGATCAAGGACATGATCCTGCAGTTCATCAGCCGGGAGAGCAGCCTCATTCTGGC
TGTCACGCCCGCCAACATGGACCTGGCCAACTCCGACGCCCTCAAGCTGGCCAAGGAAGTCGATCCCCAAGGCCTACGGACCATCGGTGT
CATCACCAAGCTTGACCTGATGGACGAGGGCACCGACGCCAGGGACGTCTTGGAGAACAAGTTGCTCCCGTTGAGAAGAGGCTACATTGG
CGTGGTGAACCGCAGCCAGAAGGATATTGAGGGCAAGAAGGACATCCGTGCAGCACTGGCAGCTGAGAGGAAGTTCTTCCTCTCCCACCC
GGCCTACCGGCACATGGCCGACCGCATGGGCACGCCACATCTGCAGAAGACGCTGAATCAGCAACTGACCAACCACATCCGGGAGTCGCT
GCCGGCCCTACGTAGCAAACTACAGAGCCAGCTGCTGTCCCTGGAGAAGGAGGTGGAGGAGTACAAGAACTTTCGGCCCGACGACCCCAC
CCGCAAAACCAAAGCCCTGCTGCAGATGGTCCAGCAGTTTGGGGTGGATTTTGAGAAGAGGATCGAGGGCTCAGGAGATCAGGTGGACAC
TCTGGAGCTCTCCGGGGGCGCCCGAATCAATCGCATCTTCCACGAGCGGTTCCCATTTGAGCTGGTGAAGATGGAGTTTGACGAGAAGGA
CTTACGACGGGAGATCAGCTATGCCATTAAGAACATCCATGGAGTCAGGACGGGGCTCTTCACCCCCGACATGGCCTTTGAAGCCATTGT
GAAAAAACAGATTGTAAAACTCAAAGAGCCGAGTTTGAAGTGTGTTGATCTCGTGGTCTCAGAGCTGGCCACGGTCATAAAAAAGTGTGC
CGAGAAGCTCAGTTCCTACCCCCGGTTGCGAGAGGAGACAGAGCGAATCGTCACCACTTACATCCGGGAACGGGAGGGGAGAACGAAGGA
CCAGATTCTTCTGCTGATCGACATTGAGCAGTCCTACATCAACACGAACCATGAGGACTTCATCGGGTTTGCCAATGCCCAGCAGAGGAG
CACGCAGCTGAACAAGAAGAGAGCCATCCCCAATCAGGGGGAGATCCTGGTGATCCGCAGGGGCTGGCTGACCATCAACAACATCAGCCT
GATGAAAGGCGGCTCCAAGGAGTACTGGTTTGTGCTGACTGCCGAGTCACTGTCCTGGTACAAGGATGAGGAGGAGAAAGAGAAGAAGTA
CATGCTGCCTCTGGACAACCTCAAGATCCGTGATGTGGAGAAGGGCTTCATGTCCAACAAGCACGTCTTCGCCATCTTCAACACGGAGCA
GAGAAACGTCTACAAGGACCTGCGGCAGATCGAGCTGGCCTGTGACTCCCAGGAAGACGTGGACAGCTGGAAGGCCTCGTTCCTCCGAGC
TGGCGTCTACCCCGAGAAGGACCAGCTGGCCCAGAAGTATGACCACCAGCGGGAGCAGGAGCTGAGAGAGTGGATCGAGGGGGTGACAGG
CCGTCGCATCGGCAACAACTTCATGGACGGCCTCAAAGATGGCATCATTCTTTGCGAATTCATCAATAAGCTGCAGCCAGGCTCCGTGAA
GAAGATCAATGAGTCAACCCAAAATTGGCACCAGCTGGAGAACATCGGCAACTTCATCAAGGCCATCACCAAGTATGGGGTGAAGCCCCA
CGACATTTTTGAGGCCAACGACCTGTTTGAGAACACCAACCATACACAGGTGCAGTCCACCCTCCTGGCTTTGGCCAGCATGGCGAAGAC
GAAAGGAAACAAGGTGAACGTGGGAGTGAAGTACGCAGAGAAGCAGGAGCGGAAATTCGAGCCGGGGAAGCTAAGAGAAGGGCGGAACAT
CATTGGGCTGCAGATGGGCACCAACAAGTTTGCCAGCCAGCAGGGCATGACGGCCTATGGCACCCGGCGCCACCTCTACGACCCCAAGCT
GGGCACAGACCAGCCTCTGGACCAGGCGACCATCAGCCTGCAGATGGGCACCAACAAAGGAGCCAGCCAGGCTGGCATGACTGCGCCAGG
GACCAAGCGGCAGATCTTCGAGCCGGGGCTGGGCATGGAGCACTGCGACACGCTCAATGTCAGCCTGCAGATGGGCAGCAACAAGGGCGC
CTCGCAGCGGGGCATGACGGTGTATGGGCTGCCACGCCAGGTCTACGACCCCAAGTACTGTCTGACTCCCGAGTACCCAGAGCTGGGTGA
GCCCGCCCACAACCACCACGCACACAACTACTACAATTCCGCCTAGGGCCACAAGGCCTTCCCTGTTTTCCCCCCAAGGGAGGCTGCTGC
TGCTCTTGGCTGGACCCAGCCAGGCCCAGCCGACCCCCTCTCCCTGCATGGCATCCTCCAGCCCCTGTAGAACTCAACCTCTACAGGGTT
AGAGTTTGGAGAGAGCAGACTGGCGGGGGGCCCATTGGGGGGAAGGGGACCCTCCGCTCTGTAGTGCTACAGGGTCCAACATAGAGCCGG
GTGTCCCCAACAGCGCCCAAAGGACGCACTGAGCAACGCTATTCCAGCTGTCCCCCCACTCCCTCACAAGTGGGTACCCCCAGGACCAGA
AGCTCCCCCAGCAAAGCCCCCAGAGCCCAGGCTCGGCCTGCCCCCACCCCATTCCCGCAGTGGGAGCAAACTGCATGCCCAGAGACCCAG
CGGACACACGCGGTTTGGTTTGCAGCGACTGGCATACTATGTGGATGTGACAGTGGCGTTTGTAATGAGAGCACTTTCTTTTTTTTCTAT
TTCACTGGAGCACAATAAATGGCTGTAAAATCTC

>23639_23639_4_DNM2-CNN1_DNM2_chr19_10934575_ENST00000389253_CNN1_chr19_11651891_ENST00000252456_length(amino acids)=907AA_BP=396
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKE
YWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKD
QLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEAND
LFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLD
QATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHA
HNYYNSA

--------------------------------------------------------------
>23639_23639_5_DNM2-CNN1_DNM2_chr19_10934575_ENST00000408974_CNN1_chr19_11651891_ENST00000252456_length(transcript)=3275nt_BP=1916nt
AGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACG
CCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGG
AGAACTTCGTGGGCCGGGACTTCCTTCCCCGCGGTTCAGGAATCGTCACCCGGCGGCCTCTCATTCTGCAGCTCATCTTCTCAAAAACAG
AACATGCCGAGTTTTTGCACTGCAAGTCCAAAAAGTTTACAGACTTTGATGAAGTCCGGCAGGAGATTGAAGCAGAGACCGACAGGGTCA
CGGGGACCAACAAAGGCATCTCCCCAGTGCCCATCAACCTTCGAGTCTACTCGCCACACGTGTTGAACTTGACCCTCATCGACCTCCCGG
GTATCACCAAGGTGCCTGTGGGCGACCAGCCTCCAGACATCGAGTACCAGATCAAGGACATGATCCTGCAGTTCATCAGCCGGGAGAGCA
GCCTCATTCTGGCTGTCACGCCCGCCAACATGGACCTGGCCAACTCCGACGCCCTCAAGCTGGCCAAGGAAGTCGATCCCCAAGGCCTAC
GGACCATCGGTGTCATCACCAAGCTTGACCTGATGGACGAGGGCACCGACGCCAGGGACGTCTTGGAGAACAAGTTGCTCCCGTTGAGAA
GAGGCTACATTGGCGTGGTGAACCGCAGCCAGAAGGATATTGAGGGCAAGAAGGACATCCGTGCAGCACTGGCAGCTGAGAGGAAGTTCT
TCCTCTCCCACCCGGCCTACCGGCACATGGCCGACCGCATGGGCACGCCACATCTGCAGAAGACGCTGAATCAGCAACTGACCAACCACA
TCCGGGAGTCGCTGCCGGCCCTACGTAGCAAACTACAGAGCCAGCTGCTGTCCCTGGAGAAGGAGGTGGAGGAGTACAAGAACTTTCGGC
CCGACGACCCCACCCGCAAAACCAAAGCCCTGCTGCAGATGGTCCAGCAGTTTGGGGTGGATTTTGAGAAGAGGATCGAGGGCTCAGGAG
ATCAGGTGGACACTCTGGAGCTCTCCGGGGGCGCCCGAATCAATCGCATCTTCCACGAGCGGTTCCCATTTGAGCTGGTGAAGATGGAGT
TTGACGAGAAGGACTTACGACGGGAGATCAGCTATGCCATTAAGAACATCCATGGAGTCAGGACGGGGCTCTTCACCCCCGACATGGCCT
TTGAAGCCATTGTGAAAAAACAGATTGTAAAACTCAAAGAGCCGAGTTTGAAGTGTGTTGATCTCGTGGTCTCAGAGCTGGCCACGGTCA
TAAAAAAGTGTGCCGAGAAGCTCAGTTCCTACCCCCGGTTGCGAGAGGAGACAGAGCGAATCGTCACCACTTACATCCGGGAACGGGAGG
GGAGAACGAAGGACCAGATTCTTCTGCTGATCGACATTGAGCAGTCCTACATCAACACGAACCATGAGGACTTCATCGGGTTTGCCAATG
CCCAGCAGAGGAGCACGCAGCTGAACAAGAAGAGAGCCATCCCCAATCAGGTGATCCGCAGGGGCTGGCTGACCATCAACAACATCAGCC
TGATGAAAGGCGGCTCCAAGGAGTACTGGTTTGTGCTGACTGCCGAGTCACTGTCCTGGTACAAGGATGAGGAGGAGAAAGAGAAGAAGT
ACATGCTGCCTCTGGACAACCTCAAGATCCGTGATGTGGAGAAGGGCTTCATGTCCAACAAGCACGTCTTCGCCATCTTCAACACGGAGC
AGAGAAACGTCTACAAGGACCTGCGGCAGATCGAGCTGGCCTGTGACTCCCAGGAAGACGTGGACAGCTGGAAGGCCTCGTTCCTCCGAG
CTGGCGTCTACCCCGAGAAGGACCAGCTGGCCCAGAAGTATGACCACCAGCGGGAGCAGGAGCTGAGAGAGTGGATCGAGGGGGTGACAG
GCCGTCGCATCGGCAACAACTTCATGGACGGCCTCAAAGATGGCATCATTCTTTGCGAATTCATCAATAAGCTGCAGCCAGGCTCCGTGA
AGAAGATCAATGAGTCAACCCAAAATTGGCACCAGCTGGAGAACATCGGCAACTTCATCAAGGCCATCACCAAGTATGGGGTGAAGCCCC
ACGACATTTTTGAGGCCAACGACCTGTTTGAGAACACCAACCATACACAGGTGCAGTCCACCCTCCTGGCTTTGGCCAGCATGGCGAAGA
CGAAAGGAAACAAGGTGAACGTGGGAGTGAAGTACGCAGAGAAGCAGGAGCGGAAATTCGAGCCGGGGAAGCTAAGAGAAGGGCGGAACA
TCATTGGGCTGCAGATGGGCACCAACAAGTTTGCCAGCCAGCAGGGCATGACGGCCTATGGCACCCGGCGCCACCTCTACGACCCCAAGC
TGGGCACAGACCAGCCTCTGGACCAGGCGACCATCAGCCTGCAGATGGGCACCAACAAAGGAGCCAGCCAGGCTGGCATGACTGCGCCAG
GGACCAAGCGGCAGATCTTCGAGCCGGGGCTGGGCATGGAGCACTGCGACACGCTCAATGTCAGCCTGCAGATGGGCAGCAACAAGGGCG
CCTCGCAGCGGGGCATGACGGTGTATGGGCTGCCACGCCAGGTCTACGACCCCAAGTACTGTCTGACTCCCGAGTACCCAGAGCTGGGTG
AGCCCGCCCACAACCACCACGCACACAACTACTACAATTCCGCCTAGGGCCACAAGGCCTTCCCTGTTTTCCCCCCAAGGGAGGCTGCTG
CTGCTCTTGGCTGGACCCAGCCAGGCCCAGCCGACCCCCTCTCCCTGCATGGCATCCTCCAGCCCCTGTAGAACTCAACCTCTACAGGGT
TAGAGTTTGGAGAGAGCAGACTGGCGGGGGGCCCATTGGGGGGAAGGGGACCCTCCGCTCTGTAGTGCTACAGGGTCCAACATAGAGCCG
GGTGTCCCCAACAGCGCCCAAAGGACGCACTGAGCAACGCTATTCCAGCTGTCCCCCCACTCCCTCACAAGTGGGTACCCCCAGGACCAG
AAGCTCCCCCAGCAAAGCCCCCAGAGCCCAGGCTCGGCCTGCCCCCACCCCATTCCCGCAGTGGGAGCAAACTGCATGCCCAGAGACCCA
GCGGACACACGCGGTTTGGTTTGCAGCGACTGGCATACTATGTGGATGTGACAGTGGCGTTTGTAATGAGAGCACTTTCTTTTTTTTCTA
TTTCACTGGAGCACAATAAATGGCTGTAAAATCTC

>23639_23639_5_DNM2-CNN1_DNM2_chr19_10934575_ENST00000408974_CNN1_chr19_11651891_ENST00000252456_length(amino acids)=903AA_BP=396
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQVIRRGWLTINNISLMKGGSKEYWFV
LTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQLAQ
KYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFEN
TNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATI
SLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHAHNYY
NSA

--------------------------------------------------------------
>23639_23639_6_DNM2-CNN1_DNM2_chr19_10934575_ENST00000585892_CNN1_chr19_11651891_ENST00000252456_length(transcript)=3416nt_BP=2057nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGACTTCCTTCCCCGCGGTTCAGGAATCGTCACCC
GGCGGCCTCTCATTCTGCAGCTCATCTTCTCAAAAACAGAACATGCCGAGTTTTTGCACTGCAAGTCCAAAAAGTTTACAGACTTTGATG
AAGTCCGGCAGGAGATTGAAGCAGAGACCGACAGGGTCACGGGGACCAACAAAGGCATCTCCCCAGTGCCCATCAACCTTCGAGTCTACT
CGCCACACGTGTTGAACTTGACCCTCATCGACCTCCCGGGTATCACCAAGGTGCCTGTGGGCGACCAGCCTCCAGACATCGAGTACCAGA
TCAAGGACATGATCCTGCAGTTCATCAGCCGGGAGAGCAGCCTCATTCTGGCTGTCACGCCCGCCAACATGGACCTGGCCAACTCCGACG
CCCTCAAGCTGGCCAAGGAAGTCGATCCCCAAGGCCTACGGACCATCGGTGTCATCACCAAGCTTGACCTGATGGACGAGGGCACCGACG
CCAGGGACGTCTTGGAGAACAAGTTGCTCCCGTTGAGAAGAGGCTACATTGGCGTGGTGAACCGCAGCCAGAAGGATATTGAGGGCAAGA
AGGACATCCGTGCAGCACTGGCAGCTGAGAGGAAGTTCTTCCTCTCCCACCCGGCCTACCGGCACATGGCCGACCGCATGGGCACGCCAC
ATCTGCAGAAGACGCTGAATCAGCAACTGACCAACCACATCCGGGAGTCGCTGCCGGCCCTACGTAGCAAACTACAGAGCCAGCTGCTGT
CCCTGGAGAAGGAGGTGGAGGAGTACAAGAACTTTCGGCCCGACGACCCCACCCGCAAAACCAAAGCCCTGCTGCAGATGGTCCAGCAGT
TTGGGGTGGATTTTGAGAAGAGGATCGAGGGCTCAGGAGATCAGGTGGACACTCTGGAGCTCTCCGGGGGCGCCCGAATCAATCGCATCT
TCCACGAGCGGTTCCCATTTGAGCTGGTGAAGATGGAGTTTGACGAGAAGGACTTACGACGGGAGATCAGCTATGCCATTAAGAACATCC
ATGGAGTCAGGACCGGGCTTTTCACCCCGGACTTGGCATTCGAGGCCATTGTGAAAAAGCAGGTCGTCAAGCTGAAAGAGCCCTGTCTGA
AATGTGTCGACCTGGTTATCCAGGAGCTAATCAATACAGTTAGGCAGTGTACCAGTAAGCTCAGTTCCTACCCCCGGTTGCGAGAGGAGA
CAGAGCGAATCGTCACCACTTACATCCGGGAACGGGAGGGGAGAACGAAGGACCAGATTCTTCTGCTGATCGACATTGAGCAGTCCTACA
TCAACACGAACCATGAGGACTTCATCGGGTTTGCCAATGCCCAGCAGAGGAGCACGCAGCTGAACAAGAAGAGAGCCATCCCCAATCAGG
GGGAGATCCTGGTGATCCGCAGGGGCTGGCTGACCATCAACAACATCAGCCTGATGAAAGGCGGCTCCAAGGAGTACTGGTTTGTGCTGA
CTGCCGAGTCACTGTCCTGGTACAAGGATGAGGAGGAGAAAGAGAAGAAGTACATGCTGCCTCTGGACAACCTCAAGATCCGTGATGTGG
AGAAGGGCTTCATGTCCAACAAGCACGTCTTCGCCATCTTCAACACGGAGCAGAGAAACGTCTACAAGGACCTGCGGCAGATCGAGCTGG
CCTGTGACTCCCAGGAAGACGTGGACAGCTGGAAGGCCTCGTTCCTCCGAGCTGGCGTCTACCCCGAGAAGGACCAGCTGGCCCAGAAGT
ATGACCACCAGCGGGAGCAGGAGCTGAGAGAGTGGATCGAGGGGGTGACAGGCCGTCGCATCGGCAACAACTTCATGGACGGCCTCAAAG
ATGGCATCATTCTTTGCGAATTCATCAATAAGCTGCAGCCAGGCTCCGTGAAGAAGATCAATGAGTCAACCCAAAATTGGCACCAGCTGG
AGAACATCGGCAACTTCATCAAGGCCATCACCAAGTATGGGGTGAAGCCCCACGACATTTTTGAGGCCAACGACCTGTTTGAGAACACCA
ACCATACACAGGTGCAGTCCACCCTCCTGGCTTTGGCCAGCATGGCGAAGACGAAAGGAAACAAGGTGAACGTGGGAGTGAAGTACGCAG
AGAAGCAGGAGCGGAAATTCGAGCCGGGGAAGCTAAGAGAAGGGCGGAACATCATTGGGCTGCAGATGGGCACCAACAAGTTTGCCAGCC
AGCAGGGCATGACGGCCTATGGCACCCGGCGCCACCTCTACGACCCCAAGCTGGGCACAGACCAGCCTCTGGACCAGGCGACCATCAGCC
TGCAGATGGGCACCAACAAAGGAGCCAGCCAGGCTGGCATGACTGCGCCAGGGACCAAGCGGCAGATCTTCGAGCCGGGGCTGGGCATGG
AGCACTGCGACACGCTCAATGTCAGCCTGCAGATGGGCAGCAACAAGGGCGCCTCGCAGCGGGGCATGACGGTGTATGGGCTGCCACGCC
AGGTCTACGACCCCAAGTACTGTCTGACTCCCGAGTACCCAGAGCTGGGTGAGCCCGCCCACAACCACCACGCACACAACTACTACAATT
CCGCCTAGGGCCACAAGGCCTTCCCTGTTTTCCCCCCAAGGGAGGCTGCTGCTGCTCTTGGCTGGACCCAGCCAGGCCCAGCCGACCCCC
TCTCCCTGCATGGCATCCTCCAGCCCCTGTAGAACTCAACCTCTACAGGGTTAGAGTTTGGAGAGAGCAGACTGGCGGGGGGCCCATTGG
GGGGAAGGGGACCCTCCGCTCTGTAGTGCTACAGGGTCCAACATAGAGCCGGGTGTCCCCAACAGCGCCCAAAGGACGCACTGAGCAACG
CTATTCCAGCTGTCCCCCCACTCCCTCACAAGTGGGTACCCCCAGGACCAGAAGCTCCCCCAGCAAAGCCCCCAGAGCCCAGGCTCGGCC
TGCCCCCACCCCATTCCCGCAGTGGGAGCAAACTGCATGCCCAGAGACCCAGCGGACACACGCGGTTTGGTTTGCAGCGACTGGCATACT
ATGTGGATGTGACAGTGGCGTTTGTAATGAGAGCACTTTCTTTTTTTTCTATTTCACTGGAGCACAATAAATGGCTGTAAAATCTC

>23639_23639_6_DNM2-CNN1_DNM2_chr19_10934575_ENST00000585892_CNN1_chr19_11651891_ENST00000252456_length(amino acids)=907AA_BP=398
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKE
YWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKD
QLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEAND
LFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLD
QATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHA
HNYYNSA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DNM2-CNN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNM2-CNN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNM2-CNN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNM2C4551952Myopathy, Centronuclear, 113CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneDNM2C1847902CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B (disorder)8CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneDNM2C1834558Myopathy, Centronuclear, Autosomal Dominant7CLINGEN;CTD_human;ORPHANET
HgeneDNM2C0175709Centronuclear myopathy2CTD_human;GENOMICS_ENGLAND
HgeneDNM2C3809272LETHAL CONGENITAL CONTRACTURE SYNDROME 52CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneDNM2C0410203X-linked centronuclear myopathy1CTD_human
HgeneDNM2C0410207Tubular Aggregate Myopathy1CTD_human
HgeneDNM2C0546264Congenital Fiber Type Disproportion1CTD_human
HgeneDNM2C0752282Congenital Structural Myopathy1CTD_human
HgeneDNM2C3645536Autosomal Recessive Centronuclear Myopathy1CTD_human
HgeneDNM2C3661489Autosomal Dominant Myotubular Myopathy1CTD_human