Fusion Gene Studies
in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DOCK1-C5orf63 (FusionGDB2 ID:HG1793TG401207)

Fusion Gene Summary for DOCK1-C5orf63

check button Fusion gene summary
Fusion gene informationFusion gene name: DOCK1-C5orf63
Fusion gene ID: hg1793tg401207
HgeneTgene
Gene symbol

DOCK1

C5orf63

Gene ID

1793

401207

Gene namededicator of cytokinesis 1chromosome 5 open reading frame 63
SynonymsDOCK180|ced5YDR286C
Cytomap('DOCK1')('C5orf63')

10q26.2

5q23.2

Type of geneprotein-codingprotein-coding
Descriptiondedicator of cytokinesis protein 1180 kDa protein downstream of CRKDOwnstream of CrKglutaredoxin-like protein C5orf63glutaredoxin-like protein YDR286C homolog
Modification date2020032720200313
UniProtAcc

Q14185

A6NC05

Ensembl transtripts involved in fusion geneENST00000280333, ENST00000484400, 
Fusion gene scores* DoF score17 X 17 X 11=31792 X 2 X 2=8
# samples 202
** MAII scorelog2(20/3179*10)=-3.99050111136325
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: DOCK1 [Title/Abstract] AND C5orf63 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDOCK1(128926028)-C5orf63(126388361), # samples:1
Anticipated loss of major functional domain due to fusion event.DOCK1-C5orf63 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DOCK1-C5orf63 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DOCK1-C5orf63 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DOCK1-C5orf63 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DOCK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across C5orf63 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A486-01ADOCK1chr10

128926028

+C5orf63chr5

126388361

-


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Fusion Gene ORF analysis for DOCK1-C5orf63

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000280333ENST00000296662DOCK1chr10

128926028

+C5orf63chr5

126388361

-
In-frameENST00000280333ENST00000509733DOCK1chr10

128926028

+C5orf63chr5

126388361

-
In-frameENST00000280333ENST00000535381DOCK1chr10

128926028

+C5orf63chr5

126388361

-
In-frameENST00000280333ENST00000606937DOCK1chr10

128926028

+C5orf63chr5

126388361

-
In-frameENST00000280333ENST00000607731DOCK1chr10

128926028

+C5orf63chr5

126388361

-
intron-3CDSENST00000484400ENST00000296662DOCK1chr10

128926028

+C5orf63chr5

126388361

-
intron-3CDSENST00000484400ENST00000509733DOCK1chr10

128926028

+C5orf63chr5

126388361

-
intron-3CDSENST00000484400ENST00000535381DOCK1chr10

128926028

+C5orf63chr5

126388361

-
intron-3CDSENST00000484400ENST00000606937DOCK1chr10

128926028

+C5orf63chr5

126388361

-
intron-3CDSENST00000484400ENST00000607731DOCK1chr10

128926028

+C5orf63chr5

126388361

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000280333DOCK1chr10128926028+ENST00000535381C5orf63chr5126388361-830828932831951055
ENST00000280333DOCK1chr10128926028+ENST00000606937C5orf63chr5126388361-333928932831951055
ENST00000280333DOCK1chr10128926028+ENST00000607731C5orf63chr5126388361-313128932830481006
ENST00000280333DOCK1chr10128926028+ENST00000296662C5orf63chr5126388361-359428932831261032
ENST00000280333DOCK1chr10128926028+ENST00000509733C5orf63chr5126388361-31812893282958976

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000280333ENST00000535381DOCK1chr10128926028+C5orf63chr5126388361-0.000240670.9997594
ENST00000280333ENST00000606937DOCK1chr10128926028+C5orf63chr5126388361-0.0004674910.9995326
ENST00000280333ENST00000607731DOCK1chr10128926028+C5orf63chr5126388361-0.0005918820.9994081
ENST00000280333ENST00000296662DOCK1chr10128926028+C5orf63chr5126388361-0.0004103740.9995896
ENST00000280333ENST00000509733DOCK1chr10128926028+C5orf63chr5126388361-0.0005330740.99946696

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Fusion Genomic Features for DOCK1-C5orf63


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DOCK1-C5orf63


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:128926028/chr5:126388361)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DOCK1

Q14185

C5orf63

A6NC05

FUNCTION: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). {ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:8657152}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDOCK1chr10:128926028chr5:126388361ENST00000280333+2752425_6099281866.0DomainC2 DOCK-type
HgeneDOCK1chr10:128926028chr5:126388361ENST00000280333+27529_709281866.0DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDOCK1chr10:128926028chr5:126388361ENST00000280333+27521207_16179281866.0DomainDOCKER
HgeneDOCK1chr10:128926028chr5:126388361ENST00000280333+27521687_16959281866.0RegionPhosphoinositide-binding


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Fusion Gene Sequence for DOCK1-C5orf63


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23757_23757_1_DOCK1-C5orf63_DOCK1_chr10_128926028_ENST00000280333_C5orf63_chr5_126388361_ENST00000296662_length(transcript)=3594nt_BP=2893nt
CTCCGCCGCAAACTTTTTCCTCCCCATCCTGTCGCGGCTCGAAAGGAATGGAAAATGGCGGCCTAGACGCGGAGTTTCCTGCCCGACCCG
CGGCGGCTCCGGCGGCGCCATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGG
AGCGGATGAACTTTCTTTACAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAA
GTCTAAGAAGGGTATATTTCCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGG
TGACCTCCCCCTCATCCAGGAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGAT
GTTTCGAAGTGTGCGGCACATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGA
ACTGAAGAAGAAGGTCACAGCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTT
GGATCCAGAATTAACTAGCACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATC
TCAAAAGCAGAACATAGATATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTG
TAAAATAGGAGAAGATGCTGAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTGAGAACTACCTGGTTCGCTGGTC
CAGTTCAGGATTACCTAAAGACATAGACAGATTACATAATTTGCGAGCCGTGTTTACTGACCTCGGAAGCAAAGACCTGAAAAGGGAGAA
AATCAGTTTTGTCTGTCAGATTGTTCGCGTGGGTCGCATGGAGCTGAGGGACAACAACACCAGGAAACTGACCTCGGGGTTGCGGCGACC
TTTTGGAGTGGCTGTGATGGATGTAACAGATATAATAAATGGAAAAGTAGATGATGAAGATAAGCAGCATTTCATTCCCTTTCAGCCGGT
GGCAGGGGAGAATGACTTCCTTCAGACTGTTATAAACAAAGTCATCGCTGCCAAAGAAGTCAACCACAAGGGGCAGGGTTTGTGGGTAAC
ATTGAAATTACTTCCTGGAGATATCCATCAGATCCGAAAAGAGTTTCCGCATTTAGTGGACAGGACCACAGCTGTGGCTCGAAAAACAGG
GTTTCCGGAGATAATCATGCCTGGTGATGTTCGAAATGATATCTATGTAACATTAGTTCAAGGAGATTTTGATAAAGGAAGCAAAACAAC
AGCGAAGAACGTGGAGGTCACGGTGTCTGTGTACGATGAGGATGGGAAACGATTAGAGCATGTGATTTTCCCGGGTGCTGGTGATGAAGC
GATTTCAGAGTACAAATCTGTGATTTACTACCAAGTAAAGCAGCCACGCTGGTTTGAGACTGTTAAGGTGGCCATTCCCATCGAGGACGT
TAACCGCAGTCACCTTCGGTTTACCTTCCGCCACAGGTCATCACAGGACTCTAAGGATAAATCTGAGAAAATATTTGCACTAGCATTTGT
CAAGCTGATGAGATACGATGGTACCACCCTGCGAGACGGAGAGCACGATCTTATCGTCTATAAGGCCGAAGCAAAGAAGCTGGAAGATGC
TGCCACGTACTTGAGTCTGCCCTCCACGAAGGCAGAGTTGGAAGAAAAGGGCCACTCGGCCACCGGCAAGAGCATGCAGAGCCTTGGGAG
CTGCACCATTAGCAAGGACTCCTTCCAGATCTCCACGCTCGTGTGCTCCACCAAACTGACTCAGAACGTGGACCTTCTGGGGCTCTTGAA
ATGGCGCTCCAACACCAGCCTGCTGCAGCAGAACTTGAGGCAGCTGATGAAAGTCGATGGTGGTGAAGTAGTGAAGTTTCTTCAGGACAC
GTTGGATGCCCTCTTCAACATCATGATGGAGAACTCAGAGAGTGAGACTTTTGACACGTTAGTCTTTGATGCTCTGGTATTTATCATTGG
ACTGATTGCTGATAGAAAATTTCAGCATTTTAATCCTGTTTTGGAAACTTACATTAAGAAACACTTTAGTGCAACGTTAGCCTACACGAA
GTTGACAAAAGTGTTGAAGAACTACGTGGACGGTGCTGAGAAGCCGGGAGTAAATGAGCAGCTGTACAAAGCCATGAAAGCGCTAGAATC
CATCTTCAAGTTCATCGTGCGCTCCAGGATCCTGTTCAATCAACTGTATGAAAACAAGGGAGAGGCTGACTTCGTGGAATCTTTGCTGCA
GCTCTTCAGGTCCATCAATGACATGATGAGCAGCATGTCAGACCAGACCGTCCGGGTGAAGGGGGCAGCACTGAAATACTTACCAACGAT
CGTCAACGATGTGAAATTGGTGTTTGATCCCAAAGAGCTCAGCAAAATGTTTACTGAATTCATCCTCAATGTTCCCATGGGCTTGCTGAC
CATCCAGAAACTCTACTGCTTGATCGAAATCGTCCACAGTGACCTCTTCACACAGCATGACTGCAGAGAGATCCTGCTTCCCATGATGAC
CGATCAGCTCAAGTACCATCTGGAGAGACAGGAGGACCTGGAGGCCTGCTGTCAGCTGCTCAGCCACATCCTGGAGGTGCTGTACAGGAA
GGACGTGGGGCCAACCCAGAGGCACGTCCAGATTATCATGGAGAAACTTCTCCGGACCGTGAACCGAACCGTCATTTCCATGGGACGAGA
TTCTGAACTCATTGACCCATGCCCCCTTTGTGATGAAGCCAAGGAAGTACTCAAGCCTTATGAAAACAGGTTCATTTTACAGGAGGTGAA
CATCACACTTCCAGAAAACTCTGTCTGGTATGAAAGGTATAAATTTGATATTCCTGTCTTTCACTTGAATGGCCAGTTTCTGATGATGCA
TCGAGTAAACACCTCAAAACTTGAAAAACAGCTCCTGAAACTTGAGCAGCAAAGTACTGGAGGCTGACTGATGCCCTCATGATTTTCCAC
CCTCTCTTCCCATAAAGCATCTTCCTAAGGAAATGACCATGGCCTGATACTCATTTTGTCACTTGTACAGAGCCCTAAGGATGTTCTGAA
TTCAGTGGTGCCAAATAAATGTTGACATTCCCCTTTTGGTTGATGGAAGTATCAGTGTGGGAACTGTTTGCTTAATGGCATTTTATAAAA
TAAGAAGAGCATATTAGCAGGGAGGGAGATGATGGAGGGAGGGAGAAGTCCATTTGTCTTATTTATCCTTTTTGTATTAATAGAGAAGCA
CTTCACAGTCACTGGGCAATGCCATTTATAGGAAGAAGGTTCTGCATTCCTGCTGCTGCCCCGGAGGGCTTAACTTTTTAATGAAAGAAT

>23757_23757_1_DOCK1-C5orf63_DOCK1_chr10_128926028_ENST00000280333_C5orf63_chr5_126388361_ENST00000296662_length(amino acids)=1032AA_BP=953
MSRLERNGKWRPRRGVSCPTRGGSGGAMTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPAS
YIHLKEAIVEGKGQHETVIPGDLPLIQEVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKI
DYGNRILDLDLVVRDEDGNILDPELTSTISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVL
MSLYDPVESKFISENYLVRWSSSGLPKDIDRLHNLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDNNTRKLTSGLRRPFGVAVMDVT
DIINGKVDDEDKQHFIPFQPVAGENDFLQTVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEIIMPGD
VRNDIYVTLVQGDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWFETVKVAIPIEDVNRSHLRFTF
RHRSSQDSKDKSEKIFALAFVKLMRYDGTTLRDGEHDLIVYKAEAKKLEDAATYLSLPSTKAELEEKGHSATGKSMQSLGSCTISKDSFQ
ISTLVCSTKLTQNVDLLGLLKWRSNTSLLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSESETFDTLVFDALVFIIGLIADRKFQH
FNPVLETYIKKHFSATLAYTKLTKVLKNYVDGAEKPGVNEQLYKAMKALESIFKFIVRSRILFNQLYENKGEADFVESLLQLFRSINDMM
SSMSDQTVRVKGAALKYLPTIVNDVKLVFDPKELSKMFTEFILNVPMGLLTIQKLYCLIEIVHSDLFTQHDCREILLPMMTDQLKYHLER
QEDLEACCQLLSHILEVLYRKDVGPTQRHVQIIMEKLLRTVNRTVISMGRDSELIDPCPLCDEAKEVLKPYENRFILQEVNITLPENSVW

--------------------------------------------------------------
>23757_23757_2_DOCK1-C5orf63_DOCK1_chr10_128926028_ENST00000280333_C5orf63_chr5_126388361_ENST00000509733_length(transcript)=3181nt_BP=2893nt
CTCCGCCGCAAACTTTTTCCTCCCCATCCTGTCGCGGCTCGAAAGGAATGGAAAATGGCGGCCTAGACGCGGAGTTTCCTGCCCGACCCG
CGGCGGCTCCGGCGGCGCCATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGG
AGCGGATGAACTTTCTTTACAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAA
GTCTAAGAAGGGTATATTTCCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGG
TGACCTCCCCCTCATCCAGGAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGAT
GTTTCGAAGTGTGCGGCACATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGA
ACTGAAGAAGAAGGTCACAGCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTT
GGATCCAGAATTAACTAGCACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATC
TCAAAAGCAGAACATAGATATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTG
TAAAATAGGAGAAGATGCTGAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTGAGAACTACCTGGTTCGCTGGTC
CAGTTCAGGATTACCTAAAGACATAGACAGATTACATAATTTGCGAGCCGTGTTTACTGACCTCGGAAGCAAAGACCTGAAAAGGGAGAA
AATCAGTTTTGTCTGTCAGATTGTTCGCGTGGGTCGCATGGAGCTGAGGGACAACAACACCAGGAAACTGACCTCGGGGTTGCGGCGACC
TTTTGGAGTGGCTGTGATGGATGTAACAGATATAATAAATGGAAAAGTAGATGATGAAGATAAGCAGCATTTCATTCCCTTTCAGCCGGT
GGCAGGGGAGAATGACTTCCTTCAGACTGTTATAAACAAAGTCATCGCTGCCAAAGAAGTCAACCACAAGGGGCAGGGTTTGTGGGTAAC
ATTGAAATTACTTCCTGGAGATATCCATCAGATCCGAAAAGAGTTTCCGCATTTAGTGGACAGGACCACAGCTGTGGCTCGAAAAACAGG
GTTTCCGGAGATAATCATGCCTGGTGATGTTCGAAATGATATCTATGTAACATTAGTTCAAGGAGATTTTGATAAAGGAAGCAAAACAAC
AGCGAAGAACGTGGAGGTCACGGTGTCTGTGTACGATGAGGATGGGAAACGATTAGAGCATGTGATTTTCCCGGGTGCTGGTGATGAAGC
GATTTCAGAGTACAAATCTGTGATTTACTACCAAGTAAAGCAGCCACGCTGGTTTGAGACTGTTAAGGTGGCCATTCCCATCGAGGACGT
TAACCGCAGTCACCTTCGGTTTACCTTCCGCCACAGGTCATCACAGGACTCTAAGGATAAATCTGAGAAAATATTTGCACTAGCATTTGT
CAAGCTGATGAGATACGATGGTACCACCCTGCGAGACGGAGAGCACGATCTTATCGTCTATAAGGCCGAAGCAAAGAAGCTGGAAGATGC
TGCCACGTACTTGAGTCTGCCCTCCACGAAGGCAGAGTTGGAAGAAAAGGGCCACTCGGCCACCGGCAAGAGCATGCAGAGCCTTGGGAG
CTGCACCATTAGCAAGGACTCCTTCCAGATCTCCACGCTCGTGTGCTCCACCAAACTGACTCAGAACGTGGACCTTCTGGGGCTCTTGAA
ATGGCGCTCCAACACCAGCCTGCTGCAGCAGAACTTGAGGCAGCTGATGAAAGTCGATGGTGGTGAAGTAGTGAAGTTTCTTCAGGACAC
GTTGGATGCCCTCTTCAACATCATGATGGAGAACTCAGAGAGTGAGACTTTTGACACGTTAGTCTTTGATGCTCTGGTATTTATCATTGG
ACTGATTGCTGATAGAAAATTTCAGCATTTTAATCCTGTTTTGGAAACTTACATTAAGAAACACTTTAGTGCAACGTTAGCCTACACGAA
GTTGACAAAAGTGTTGAAGAACTACGTGGACGGTGCTGAGAAGCCGGGAGTAAATGAGCAGCTGTACAAAGCCATGAAAGCGCTAGAATC
CATCTTCAAGTTCATCGTGCGCTCCAGGATCCTGTTCAATCAACTGTATGAAAACAAGGGAGAGGCTGACTTCGTGGAATCTTTGCTGCA
GCTCTTCAGGTCCATCAATGACATGATGAGCAGCATGTCAGACCAGACCGTCCGGGTGAAGGGGGCAGCACTGAAATACTTACCAACGAT
CGTCAACGATGTGAAATTGGTGTTTGATCCCAAAGAGCTCAGCAAAATGTTTACTGAATTCATCCTCAATGTTCCCATGGGCTTGCTGAC
CATCCAGAAACTCTACTGCTTGATCGAAATCGTCCACAGTGACCTCTTCACACAGCATGACTGCAGAGAGATCCTGCTTCCCATGATGAC
CGATCAGCTCAAGTACCATCTGGAGAGACAGGAGGACCTGGAGGCCTGCTGTCAGCTGCTCAGCCACATCCTGGAGGTGCTGTACAGGAA
GGACGTGGGGCCAACCCAGAGGCACGTCCAGATTATCATGGAGAAACTTCTCCGGACCGTGAACCGAACCGTCATTTCCATGGGACGAGA
TTCTGAACTCATTGACCCATGCCCCCTTTGTGATGAAGCCAAGGAAGTACTCAAGCCTTATGAAAACAGGGTAATATAATACAGTGTGGC
TTTTATGTATATGGATTGCATATTAGATGTGGTATAAAGTATCTGCCTGGATCCTTCCTTTAGGAAAAGAGATTAAATGATTTTTCTTTT
AAATTTTCTTTCTGTTCTTCAGAGAGAGAGTTTAGTGCTTATTACCATAAAACTCATTACACCTAAGTGTTTTCCTCTGAGCAGTACTGG

>23757_23757_2_DOCK1-C5orf63_DOCK1_chr10_128926028_ENST00000280333_C5orf63_chr5_126388361_ENST00000509733_length(amino acids)=976AA_BP=953
MSRLERNGKWRPRRGVSCPTRGGSGGAMTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPAS
YIHLKEAIVEGKGQHETVIPGDLPLIQEVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKI
DYGNRILDLDLVVRDEDGNILDPELTSTISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVL
MSLYDPVESKFISENYLVRWSSSGLPKDIDRLHNLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDNNTRKLTSGLRRPFGVAVMDVT
DIINGKVDDEDKQHFIPFQPVAGENDFLQTVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEIIMPGD
VRNDIYVTLVQGDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWFETVKVAIPIEDVNRSHLRFTF
RHRSSQDSKDKSEKIFALAFVKLMRYDGTTLRDGEHDLIVYKAEAKKLEDAATYLSLPSTKAELEEKGHSATGKSMQSLGSCTISKDSFQ
ISTLVCSTKLTQNVDLLGLLKWRSNTSLLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSESETFDTLVFDALVFIIGLIADRKFQH
FNPVLETYIKKHFSATLAYTKLTKVLKNYVDGAEKPGVNEQLYKAMKALESIFKFIVRSRILFNQLYENKGEADFVESLLQLFRSINDMM
SSMSDQTVRVKGAALKYLPTIVNDVKLVFDPKELSKMFTEFILNVPMGLLTIQKLYCLIEIVHSDLFTQHDCREILLPMMTDQLKYHLER

--------------------------------------------------------------
>23757_23757_3_DOCK1-C5orf63_DOCK1_chr10_128926028_ENST00000280333_C5orf63_chr5_126388361_ENST00000535381_length(transcript)=8308nt_BP=2893nt
CTCCGCCGCAAACTTTTTCCTCCCCATCCTGTCGCGGCTCGAAAGGAATGGAAAATGGCGGCCTAGACGCGGAGTTTCCTGCCCGACCCG
CGGCGGCTCCGGCGGCGCCATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGG
AGCGGATGAACTTTCTTTACAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAA
GTCTAAGAAGGGTATATTTCCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGG
TGACCTCCCCCTCATCCAGGAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGAT
GTTTCGAAGTGTGCGGCACATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGA
ACTGAAGAAGAAGGTCACAGCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTT
GGATCCAGAATTAACTAGCACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATC
TCAAAAGCAGAACATAGATATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTG
TAAAATAGGAGAAGATGCTGAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTGAGAACTACCTGGTTCGCTGGTC
CAGTTCAGGATTACCTAAAGACATAGACAGATTACATAATTTGCGAGCCGTGTTTACTGACCTCGGAAGCAAAGACCTGAAAAGGGAGAA
AATCAGTTTTGTCTGTCAGATTGTTCGCGTGGGTCGCATGGAGCTGAGGGACAACAACACCAGGAAACTGACCTCGGGGTTGCGGCGACC
TTTTGGAGTGGCTGTGATGGATGTAACAGATATAATAAATGGAAAAGTAGATGATGAAGATAAGCAGCATTTCATTCCCTTTCAGCCGGT
GGCAGGGGAGAATGACTTCCTTCAGACTGTTATAAACAAAGTCATCGCTGCCAAAGAAGTCAACCACAAGGGGCAGGGTTTGTGGGTAAC
ATTGAAATTACTTCCTGGAGATATCCATCAGATCCGAAAAGAGTTTCCGCATTTAGTGGACAGGACCACAGCTGTGGCTCGAAAAACAGG
GTTTCCGGAGATAATCATGCCTGGTGATGTTCGAAATGATATCTATGTAACATTAGTTCAAGGAGATTTTGATAAAGGAAGCAAAACAAC
AGCGAAGAACGTGGAGGTCACGGTGTCTGTGTACGATGAGGATGGGAAACGATTAGAGCATGTGATTTTCCCGGGTGCTGGTGATGAAGC
GATTTCAGAGTACAAATCTGTGATTTACTACCAAGTAAAGCAGCCACGCTGGTTTGAGACTGTTAAGGTGGCCATTCCCATCGAGGACGT
TAACCGCAGTCACCTTCGGTTTACCTTCCGCCACAGGTCATCACAGGACTCTAAGGATAAATCTGAGAAAATATTTGCACTAGCATTTGT
CAAGCTGATGAGATACGATGGTACCACCCTGCGAGACGGAGAGCACGATCTTATCGTCTATAAGGCCGAAGCAAAGAAGCTGGAAGATGC
TGCCACGTACTTGAGTCTGCCCTCCACGAAGGCAGAGTTGGAAGAAAAGGGCCACTCGGCCACCGGCAAGAGCATGCAGAGCCTTGGGAG
CTGCACCATTAGCAAGGACTCCTTCCAGATCTCCACGCTCGTGTGCTCCACCAAACTGACTCAGAACGTGGACCTTCTGGGGCTCTTGAA
ATGGCGCTCCAACACCAGCCTGCTGCAGCAGAACTTGAGGCAGCTGATGAAAGTCGATGGTGGTGAAGTAGTGAAGTTTCTTCAGGACAC
GTTGGATGCCCTCTTCAACATCATGATGGAGAACTCAGAGAGTGAGACTTTTGACACGTTAGTCTTTGATGCTCTGGTATTTATCATTGG
ACTGATTGCTGATAGAAAATTTCAGCATTTTAATCCTGTTTTGGAAACTTACATTAAGAAACACTTTAGTGCAACGTTAGCCTACACGAA
GTTGACAAAAGTGTTGAAGAACTACGTGGACGGTGCTGAGAAGCCGGGAGTAAATGAGCAGCTGTACAAAGCCATGAAAGCGCTAGAATC
CATCTTCAAGTTCATCGTGCGCTCCAGGATCCTGTTCAATCAACTGTATGAAAACAAGGGAGAGGCTGACTTCGTGGAATCTTTGCTGCA
GCTCTTCAGGTCCATCAATGACATGATGAGCAGCATGTCAGACCAGACCGTCCGGGTGAAGGGGGCAGCACTGAAATACTTACCAACGAT
CGTCAACGATGTGAAATTGGTGTTTGATCCCAAAGAGCTCAGCAAAATGTTTACTGAATTCATCCTCAATGTTCCCATGGGCTTGCTGAC
CATCCAGAAACTCTACTGCTTGATCGAAATCGTCCACAGTGACCTCTTCACACAGCATGACTGCAGAGAGATCCTGCTTCCCATGATGAC
CGATCAGCTCAAGTACCATCTGGAGAGACAGGAGGACCTGGAGGCCTGCTGTCAGCTGCTCAGCCACATCCTGGAGGTGCTGTACAGGAA
GGACGTGGGGCCAACCCAGAGGCACGTCCAGATTATCATGGAGAAACTTCTCCGGACCGTGAACCGAACCGTCATTTCCATGGGACGAGA
TTCTGAACTCATTGACCCATGCCCCCTTTGTGATGAAGCCAAGGAAGTACTCAAGCCTTATGAAAACAGGCAACCCTACAAGGATCAGAA
GCTGCCAGGAACAAGGAGAAGACGCTCCCCTTCCTCACCTTCCCACCCCCACATGGCTTCTCAGTCGGGGAAAAGATACAACTTAACTTT
AAACCAAGTCTTAAGTTTTGATTATGACATGGGATTAGATGCACCAAAAACAATTTCAAGTGACTGTGGGGCATTCTATTGCCTGAGAAT
GTTCAAGAGTCCTGATATGACCTGTTGTTTTTATCCTAAACAGTGAAAAATTCATCCACCAAATATATAGGAATAGAGGGAGACAGAAAG
ATGCTTTCTGAAGGTATCCCATATTTAGAGTATTGGTTACATATACCTAATGTTGGTTTTAACCTATAGCTCTTCAATAAACTTACTCAT
CAATTCTTATTTCAGAGAGGAATATGGTCATGTGACTAGGAATCCTGCAGATCTTCAGCAAACCCATGGGTCCCAACAGCTGGCAAAATG
AAAGGTAGATACCTACAAACATGGCATCTAAAAGGTGGTTTGATTATCCCACTGTCAAGTATCAGTGTTATGTCACCTATTACTGTGATT
TTCATGTGATGTTTGTAGCAGCAATTACTTTTCCTTTCTGAAATTATGTTTGCAAAGATCAATTTGTTTTTATATAAAGATTAACTTTGA
TATAAGAAGCTCATCATTCACCTCCAAAGGAAAAGGTGATACAAGCTTCCTTTTTTTCCCCCTTCAAGCTAATGCCTTATGAAGGAGTGG
AATAGTTTGGGACTTCATATTGCTGCTCTAGAATAGTGCCTCTTTCTTCCACATGTCTCTTCATAACATTATGAGCTTACTGGAACACAT
AGCTCTTTGGCCAGTTTATTGCACGAAACAAGGGTATACTCAGACTGGGGTTTTTTAAATAATGCAGCAATCTCATGGACATCTGACAGT
AGGAATCACAATACAGCCAGGCTTCAGAAGTACAATTAAAGAACCACCCAAAACTGAAACATCACCCTTCTCACAGTGCCTTGGCTTATT
TTCTTCCTTGTTCTCTCCTGGCTCACAGCTCCCCTGCTTACACACACTATCTGCTTCCTCATAGCTGCAGCCTGCTTATGCCCATCATTA
CTGCTAACCTTTCTGTTCAGCAATACAGCACCCTGAGCCTCTCAGGCTTCTCTATTCTGAAATCCTAAAAGGAATTTTACTCAGCTTATA
TTTTACAACCAGGCACCCATGACCTAAGTTGGCTGACCAAATCTATAGAAGGAGCCACCTTTAGGACAGAAGCCTATCCCTGGGCCAACT
GGCTATGGAAGCGGTATGCAAATCACAGTCACTGCCCACTGGCAGAGGCCAGAAGCAGGACAGGCAATGACCAGCAACTCTGGCACGCCT
CCAAAAAGCTTAAGAATGTGACATTCTACCATACTCAAGAGAAGTCAGGAGGGACACATTGGTAAGTTCACTTATATCCTACTCCATAGG
AGTAATAAGGACATGAACCAAAGCAATGGGAGTCAGACAGAAAGAGATATCAGGAGATATTTAGGAGTGAGGTTGACAAAACTTCATGAC
TGACTGGATGGGTCGGTAGTGATGTGGAGAGGGGAGTAGAGAGAAAGCATGGATTCTGGGATAACTCCCAGTTTTCTTGCTTACACTACT
GGGTGAATTCTGATACTTTTTATTCCCTGAGGCAGAGAATGTAAGAGGAAGGAAAAGTTAGTTTTGGGCTGTGCTTGGTGGATGGGAAAG
GTAAGACATGGTGAATTCTCCATGCTTGTGGGATATCAAGGTAAAGATAAAAGTTAGAAGTGCAAAACAAAGGTCTGGGGTTAAGGTATA
CATTTGAGAGCCCACTGAGTATGGTTGGAAATGTGGCCACCTGGCATATAAGGAGAAAAGCAAGCTATTCCCAAACCATGGAGAATACTA
ATCTTGACCCATGAGAATAGAGGAAGTTGCTAGTGAAGGAAAATGAGAGAGTGGTGGTGGAACTAGGAATGGGAGAAGCTCATCCAATTT
ACATTACGTGATGCCTTTTGTGATTTGATAGTGGCAGGTATTATTCCAAGCACTGGGGATAAAACAACAAACAAGATAGCCAGGATTCCT
ACTCTCAGAGTCTTGCATTTTAAGGGAGAGACAGACAATAAAGATATCGTATCAGAGGAAAATAATCATGAAAGTCAGGGAGGAGCTTTT
CCCAGAGTAACTGACAGTATCAAATAGCAAGAGAGTTAGGATGAGGACTGAACAGAAGACATCAGATTTGAAAATTAGAAAATCAGTGCT
GCTATAGGAAGAATAGTCCCCAAAGATACCCAGGTCCTAATTCCTGGAACCTGTCACTTATATGCATAAAGGACTTTGCAGATTTAAGTT
AAGGATCTTGAGATGGGAAAATTATATTGCATTATCTAAGCAGGTCCTAATGTAATCACAGGTGTCTCTATAAGAGGGAGTCAGAAGGAG
ATTTGACTAGGGTAAAGAGAGTAGGAAATTCGACAATGGAAGCAAAAGGTTGGAGTGATACAAGAAAGCAGCCATGAGCCAAGGAATGTG
AATGGCCTCCAGAAGCTAAGAAAAGAAAAAGAAAACAGATTATCCCCTATAGCCTCCCGAAGGAGCAAGCCCTGCTGACACGTTTACTTT
AGTTCTGTGAAACTGATTTCTGACTTCTGGCCTATAGAACTATGAGAGAATAAATTTGTGTTGTTTTAAGCCAAGTTTGTGATAATTTGG
TACAGCAGCAATAGAAAATGAATACAAATGTTTCCTTGACCTTATTGAGAACAACTTTTGTGGAGAGGGAAGAGGTAAACTAAAAGAAAA
TTGTGGTGGGATGATAACTGAAAGATACAGAAAAGACAGCAAAGTATCCATTTTTTAGGAAGTTTTTATATATCTCATTTGACCCACTAA
GAAACGACATCCAGAAAGGAGCTAAAGACCAGAGGTAATTGATTAGCTCAGCACCCAAAAATGGCAGGCAGTGTTGGGGCAGTACTAGAA
TGAGGTAGCCGGCCGGGCACGGTGGCTCATGCCTGTAATGCCAGCTCTCAGGGAGGCAAGAGGTGGGAGTATAGCTTGAGCCCAGGAGTT
CGAGACCTGCCTGGGCAATATAGCAAGACCCCGTTCTCCAGAAAAAGGAAAAAAAAAAAAAAAAAAGCATAGAATGAGGTAGCCATAACA
TTCTACCTGGCTTTTGGCTGAATTGTGGGGAGGAGAGTTCAGAGGCCTCAAAAGTGACCCTGACACTGGAGAGTAAACCATAGTAACCCA
TTATAGTCCACAGATATGCGCACCAGACCCATGACTCTTGTTCACCATAGAGACAGGATACTTTGATGCTGTGACCCAAAATCCTGCACC
TGGAACAGATTTGGTACCTCTCTATTGACACAGAAATTCATGTTGAGCATGGAGACATAATCAAGAGAGAATGGCCTCATTCGATCGGTC
TTCAGCTTAGGCACTGACATTTTGCATTTTACCTCCTCTCTCAGGTTCAAAGATGACTACCAAAGCTAAACCTCTGAATTCTAAAGTCTA
CAAGGACATAAAGCTTCAGGGAAAGGGGAAATATTAATATTAATATTAATGTCATACAAAAGAGGAGAAGCAGCACATAGGAGTGCCAGC
TAATAGACTAGTAGTAATAAGAAGAATCCAACCATAGGCCTATATTGAGAGTCATGGGCATCCCTTCTTTATGCTGAAATGGTATATTTG
AACGGAATTCCTGATGGAAAACTTTCTATCCTTAGAAATACTGTAGGCCAAATATTAATTGGAACTTTTGTTAATGATTTGAGAACACCA
AAAAGTTTAGATGATACAAGTTAAAGGCAAATTGAGCCCATGGCCTCATTGTGCTACTTAGAATACCCTGTGACCCAGCTCTCCTCAGAA
ACCCTGATGGCTTTGTTGCAGCATTGCATTGCACAGAAGACCTCAGTGGTGGTCCTGAGTCCTCACAACAAGGTCAACCCGTGGCCTGGC
CACTAAGGCAACAGAGAGGGAAATAAATTTTAGAAAACGCTTCCCTTAAAAATGAGTTAAAATGTACATTTGCATCATGAGACTAGGTTA
ACTGTCACCTGAGAAAGTCCTATATTCAGAAAGACTTAATCCTGGACCAGGTAAATGAGGCATTTGCTGTATGTTCTTTGTTATGAATTT
AATGCTACAAAGAGAAAATGGGCATTGATGCATAATCTGGGTAAAAAAGAGATGTCAGAAGTTGGGAAAGAACTGCCAGAAGAGCTATGT
TTTAGGATTTCACTCCACCTTACCCTGTGTTTTCTTGTAAAGATATTCTCAAAATTAGGCCAATTTCACTCTTTTAAGGTCAGAGGAGAT
TAAGATATTTAGAAATCAGATTGTGGGATTGATTCCCATTGTGATTGCTGACTTTTAGTATCAGCCTTTTGTTCTGCATGGATTCTCTCA
TCTTGCAAACTAGCAAGACTCCTGAATTTGGCAATGATCCTGCTCTGTGAAGCATTCTCAAGTTAGGGTTCTTATCAATGTCAGATTTCA
CTAAGCCAGTAATAAAGGAAAGGTTGAGAGAGCAAAGGATGTCACTGAGTTGACACCTAACAGCACAAAACAACTTGTCAGCTGGCAGGA
CAAGCCAGCATGTTCAGGGTGGTCACAGCCTTTGAGTTGGAAAGATAGTCTTTTAAACATTCTTACCTCACCAAATAACTTTAATAGATA
AAATTTAGTTACTCCCTCCCACTTTTGTTCTATTCATTTAAAGCAGTGTTTTTTAAAAATTTATGTATATGTGACTACATGAAAAATACA
TTACTGTGTTTCTTGATGTTTTATGACCTGTACACAAAGTGAGACCAGCAGATGCCTTCAAGAGAAATAAAGGACACTGCTGTCATTCTA
ACTAAATTGTCCAGAGGAGGAAAGAAGAGTACAAAAATGATTATGAATACTTAAGAAGAGGCATGACTTTGTCATTGGTGTGGAGCCTAT
AATTATGTGCAATTCCCTACTTAAGACTTTTTAGTTATGCTGAACATTGAAAAAAAACTAAACAGCGGAGAGGAGAAAAGAAAAGGGGAA
ATTTAAACATTTAATGGAACACATTCATTAAATGGAGACATCGCTTCACCATAAGGGGGCAGTTAAGGGTTTGGTAGTCCTACTCACTTG
CTATTGTCAAATCATTTGTTTTATCATGGATTTGAGATCCTTATAAGTCTTCATTATTATTTTGAATTCAAGAATGATTCCTTCTGCTCA
CAAAACATGATCACTTTTCATTGATTTTTTTTTTTAATATTCTGACTGGTTTTGCATATCTGGAAAAGATAAATCTTCAAAATTTGGAAA

>23757_23757_3_DOCK1-C5orf63_DOCK1_chr10_128926028_ENST00000280333_C5orf63_chr5_126388361_ENST00000535381_length(amino acids)=1055AA_BP=953
MSRLERNGKWRPRRGVSCPTRGGSGGAMTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPAS
YIHLKEAIVEGKGQHETVIPGDLPLIQEVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKI
DYGNRILDLDLVVRDEDGNILDPELTSTISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVL
MSLYDPVESKFISENYLVRWSSSGLPKDIDRLHNLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDNNTRKLTSGLRRPFGVAVMDVT
DIINGKVDDEDKQHFIPFQPVAGENDFLQTVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEIIMPGD
VRNDIYVTLVQGDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWFETVKVAIPIEDVNRSHLRFTF
RHRSSQDSKDKSEKIFALAFVKLMRYDGTTLRDGEHDLIVYKAEAKKLEDAATYLSLPSTKAELEEKGHSATGKSMQSLGSCTISKDSFQ
ISTLVCSTKLTQNVDLLGLLKWRSNTSLLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSESETFDTLVFDALVFIIGLIADRKFQH
FNPVLETYIKKHFSATLAYTKLTKVLKNYVDGAEKPGVNEQLYKAMKALESIFKFIVRSRILFNQLYENKGEADFVESLLQLFRSINDMM
SSMSDQTVRVKGAALKYLPTIVNDVKLVFDPKELSKMFTEFILNVPMGLLTIQKLYCLIEIVHSDLFTQHDCREILLPMMTDQLKYHLER
QEDLEACCQLLSHILEVLYRKDVGPTQRHVQIIMEKLLRTVNRTVISMGRDSELIDPCPLCDEAKEVLKPYENRQPYKDQKLPGTRRRRS

--------------------------------------------------------------
>23757_23757_4_DOCK1-C5orf63_DOCK1_chr10_128926028_ENST00000280333_C5orf63_chr5_126388361_ENST00000606937_length(transcript)=3339nt_BP=2893nt
CTCCGCCGCAAACTTTTTCCTCCCCATCCTGTCGCGGCTCGAAAGGAATGGAAAATGGCGGCCTAGACGCGGAGTTTCCTGCCCGACCCG
CGGCGGCTCCGGCGGCGCCATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGG
AGCGGATGAACTTTCTTTACAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAA
GTCTAAGAAGGGTATATTTCCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGG
TGACCTCCCCCTCATCCAGGAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGAT
GTTTCGAAGTGTGCGGCACATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGA
ACTGAAGAAGAAGGTCACAGCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTT
GGATCCAGAATTAACTAGCACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATC
TCAAAAGCAGAACATAGATATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTG
TAAAATAGGAGAAGATGCTGAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTGAGAACTACCTGGTTCGCTGGTC
CAGTTCAGGATTACCTAAAGACATAGACAGATTACATAATTTGCGAGCCGTGTTTACTGACCTCGGAAGCAAAGACCTGAAAAGGGAGAA
AATCAGTTTTGTCTGTCAGATTGTTCGCGTGGGTCGCATGGAGCTGAGGGACAACAACACCAGGAAACTGACCTCGGGGTTGCGGCGACC
TTTTGGAGTGGCTGTGATGGATGTAACAGATATAATAAATGGAAAAGTAGATGATGAAGATAAGCAGCATTTCATTCCCTTTCAGCCGGT
GGCAGGGGAGAATGACTTCCTTCAGACTGTTATAAACAAAGTCATCGCTGCCAAAGAAGTCAACCACAAGGGGCAGGGTTTGTGGGTAAC
ATTGAAATTACTTCCTGGAGATATCCATCAGATCCGAAAAGAGTTTCCGCATTTAGTGGACAGGACCACAGCTGTGGCTCGAAAAACAGG
GTTTCCGGAGATAATCATGCCTGGTGATGTTCGAAATGATATCTATGTAACATTAGTTCAAGGAGATTTTGATAAAGGAAGCAAAACAAC
AGCGAAGAACGTGGAGGTCACGGTGTCTGTGTACGATGAGGATGGGAAACGATTAGAGCATGTGATTTTCCCGGGTGCTGGTGATGAAGC
GATTTCAGAGTACAAATCTGTGATTTACTACCAAGTAAAGCAGCCACGCTGGTTTGAGACTGTTAAGGTGGCCATTCCCATCGAGGACGT
TAACCGCAGTCACCTTCGGTTTACCTTCCGCCACAGGTCATCACAGGACTCTAAGGATAAATCTGAGAAAATATTTGCACTAGCATTTGT
CAAGCTGATGAGATACGATGGTACCACCCTGCGAGACGGAGAGCACGATCTTATCGTCTATAAGGCCGAAGCAAAGAAGCTGGAAGATGC
TGCCACGTACTTGAGTCTGCCCTCCACGAAGGCAGAGTTGGAAGAAAAGGGCCACTCGGCCACCGGCAAGAGCATGCAGAGCCTTGGGAG
CTGCACCATTAGCAAGGACTCCTTCCAGATCTCCACGCTCGTGTGCTCCACCAAACTGACTCAGAACGTGGACCTTCTGGGGCTCTTGAA
ATGGCGCTCCAACACCAGCCTGCTGCAGCAGAACTTGAGGCAGCTGATGAAAGTCGATGGTGGTGAAGTAGTGAAGTTTCTTCAGGACAC
GTTGGATGCCCTCTTCAACATCATGATGGAGAACTCAGAGAGTGAGACTTTTGACACGTTAGTCTTTGATGCTCTGGTATTTATCATTGG
ACTGATTGCTGATAGAAAATTTCAGCATTTTAATCCTGTTTTGGAAACTTACATTAAGAAACACTTTAGTGCAACGTTAGCCTACACGAA
GTTGACAAAAGTGTTGAAGAACTACGTGGACGGTGCTGAGAAGCCGGGAGTAAATGAGCAGCTGTACAAAGCCATGAAAGCGCTAGAATC
CATCTTCAAGTTCATCGTGCGCTCCAGGATCCTGTTCAATCAACTGTATGAAAACAAGGGAGAGGCTGACTTCGTGGAATCTTTGCTGCA
GCTCTTCAGGTCCATCAATGACATGATGAGCAGCATGTCAGACCAGACCGTCCGGGTGAAGGGGGCAGCACTGAAATACTTACCAACGAT
CGTCAACGATGTGAAATTGGTGTTTGATCCCAAAGAGCTCAGCAAAATGTTTACTGAATTCATCCTCAATGTTCCCATGGGCTTGCTGAC
CATCCAGAAACTCTACTGCTTGATCGAAATCGTCCACAGTGACCTCTTCACACAGCATGACTGCAGAGAGATCCTGCTTCCCATGATGAC
CGATCAGCTCAAGTACCATCTGGAGAGACAGGAGGACCTGGAGGCCTGCTGTCAGCTGCTCAGCCACATCCTGGAGGTGCTGTACAGGAA
GGACGTGGGGCCAACCCAGAGGCACGTCCAGATTATCATGGAGAAACTTCTCCGGACCGTGAACCGAACCGTCATTTCCATGGGACGAGA
TTCTGAACTCATTGACCCATGCCCCCTTTGTGATGAAGCCAAGGAAGTACTCAAGCCTTATGAAAACAGGCAACCCTACAAGGATCAGAA
GCTGCCAGGAACAAGGAGAAGACGCTCCCCTTCCTCACCTTCCCACCCCCACATGGCTTCTCAGTCGGGGAAAAGATACAACTTAACTTT
AAACCAAGTCTTAAGTTTTGATTATGACATGGGATTAGATGCACCAAAAACAATTTCAAGTGACTGTGGGGCATTCTATTGCCTGAGAAT
GTTCAAGAGTCCTGATATGACCTGTTGTTTTTATCCTAAACAGTGAAAAATTCATCCACCAAATATATAGGAATAGAGGGAGACAGAAAG
ATGCTTTCTGAAGGTATCCCATATTTAGAGTATTGGTTACATATACCTAATGTTGGTTTTAACCTATAGCTCTTCAATAAACTTACTCAT

>23757_23757_4_DOCK1-C5orf63_DOCK1_chr10_128926028_ENST00000280333_C5orf63_chr5_126388361_ENST00000606937_length(amino acids)=1055AA_BP=953
MSRLERNGKWRPRRGVSCPTRGGSGGAMTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPAS
YIHLKEAIVEGKGQHETVIPGDLPLIQEVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKI
DYGNRILDLDLVVRDEDGNILDPELTSTISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVL
MSLYDPVESKFISENYLVRWSSSGLPKDIDRLHNLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDNNTRKLTSGLRRPFGVAVMDVT
DIINGKVDDEDKQHFIPFQPVAGENDFLQTVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEIIMPGD
VRNDIYVTLVQGDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWFETVKVAIPIEDVNRSHLRFTF
RHRSSQDSKDKSEKIFALAFVKLMRYDGTTLRDGEHDLIVYKAEAKKLEDAATYLSLPSTKAELEEKGHSATGKSMQSLGSCTISKDSFQ
ISTLVCSTKLTQNVDLLGLLKWRSNTSLLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSESETFDTLVFDALVFIIGLIADRKFQH
FNPVLETYIKKHFSATLAYTKLTKVLKNYVDGAEKPGVNEQLYKAMKALESIFKFIVRSRILFNQLYENKGEADFVESLLQLFRSINDMM
SSMSDQTVRVKGAALKYLPTIVNDVKLVFDPKELSKMFTEFILNVPMGLLTIQKLYCLIEIVHSDLFTQHDCREILLPMMTDQLKYHLER
QEDLEACCQLLSHILEVLYRKDVGPTQRHVQIIMEKLLRTVNRTVISMGRDSELIDPCPLCDEAKEVLKPYENRQPYKDQKLPGTRRRRS

--------------------------------------------------------------
>23757_23757_5_DOCK1-C5orf63_DOCK1_chr10_128926028_ENST00000280333_C5orf63_chr5_126388361_ENST00000607731_length(transcript)=3131nt_BP=2893nt
CTCCGCCGCAAACTTTTTCCTCCCCATCCTGTCGCGGCTCGAAAGGAATGGAAAATGGCGGCCTAGACGCGGAGTTTCCTGCCCGACCCG
CGGCGGCTCCGGCGGCGCCATGACGCGCTGGGTGCCCACCAAGCGCGAGGAGAAGTACGGCGTGGCTTTTTATAACTATGATGCCAGAGG
AGCGGATGAACTTTCTTTACAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAA
GTCTAAGAAGGGTATATTTCCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGG
TGACCTCCCCCTCATCCAGGAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGAT
GTTTCGAAGTGTGCGGCACATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGA
ACTGAAGAAGAAGGTCACAGCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTT
GGATCCAGAATTAACTAGCACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATC
TCAAAAGCAGAACATAGATATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTG
TAAAATAGGAGAAGATGCTGAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTGAGAACTACCTGGTTCGCTGGTC
CAGTTCAGGATTACCTAAAGACATAGACAGATTACATAATTTGCGAGCCGTGTTTACTGACCTCGGAAGCAAAGACCTGAAAAGGGAGAA
AATCAGTTTTGTCTGTCAGATTGTTCGCGTGGGTCGCATGGAGCTGAGGGACAACAACACCAGGAAACTGACCTCGGGGTTGCGGCGACC
TTTTGGAGTGGCTGTGATGGATGTAACAGATATAATAAATGGAAAAGTAGATGATGAAGATAAGCAGCATTTCATTCCCTTTCAGCCGGT
GGCAGGGGAGAATGACTTCCTTCAGACTGTTATAAACAAAGTCATCGCTGCCAAAGAAGTCAACCACAAGGGGCAGGGTTTGTGGGTAAC
ATTGAAATTACTTCCTGGAGATATCCATCAGATCCGAAAAGAGTTTCCGCATTTAGTGGACAGGACCACAGCTGTGGCTCGAAAAACAGG
GTTTCCGGAGATAATCATGCCTGGTGATGTTCGAAATGATATCTATGTAACATTAGTTCAAGGAGATTTTGATAAAGGAAGCAAAACAAC
AGCGAAGAACGTGGAGGTCACGGTGTCTGTGTACGATGAGGATGGGAAACGATTAGAGCATGTGATTTTCCCGGGTGCTGGTGATGAAGC
GATTTCAGAGTACAAATCTGTGATTTACTACCAAGTAAAGCAGCCACGCTGGTTTGAGACTGTTAAGGTGGCCATTCCCATCGAGGACGT
TAACCGCAGTCACCTTCGGTTTACCTTCCGCCACAGGTCATCACAGGACTCTAAGGATAAATCTGAGAAAATATTTGCACTAGCATTTGT
CAAGCTGATGAGATACGATGGTACCACCCTGCGAGACGGAGAGCACGATCTTATCGTCTATAAGGCCGAAGCAAAGAAGCTGGAAGATGC
TGCCACGTACTTGAGTCTGCCCTCCACGAAGGCAGAGTTGGAAGAAAAGGGCCACTCGGCCACCGGCAAGAGCATGCAGAGCCTTGGGAG
CTGCACCATTAGCAAGGACTCCTTCCAGATCTCCACGCTCGTGTGCTCCACCAAACTGACTCAGAACGTGGACCTTCTGGGGCTCTTGAA
ATGGCGCTCCAACACCAGCCTGCTGCAGCAGAACTTGAGGCAGCTGATGAAAGTCGATGGTGGTGAAGTAGTGAAGTTTCTTCAGGACAC
GTTGGATGCCCTCTTCAACATCATGATGGAGAACTCAGAGAGTGAGACTTTTGACACGTTAGTCTTTGATGCTCTGGTATTTATCATTGG
ACTGATTGCTGATAGAAAATTTCAGCATTTTAATCCTGTTTTGGAAACTTACATTAAGAAACACTTTAGTGCAACGTTAGCCTACACGAA
GTTGACAAAAGTGTTGAAGAACTACGTGGACGGTGCTGAGAAGCCGGGAGTAAATGAGCAGCTGTACAAAGCCATGAAAGCGCTAGAATC
CATCTTCAAGTTCATCGTGCGCTCCAGGATCCTGTTCAATCAACTGTATGAAAACAAGGGAGAGGCTGACTTCGTGGAATCTTTGCTGCA
GCTCTTCAGGTCCATCAATGACATGATGAGCAGCATGTCAGACCAGACCGTCCGGGTGAAGGGGGCAGCACTGAAATACTTACCAACGAT
CGTCAACGATGTGAAATTGGTGTTTGATCCCAAAGAGCTCAGCAAAATGTTTACTGAATTCATCCTCAATGTTCCCATGGGCTTGCTGAC
CATCCAGAAACTCTACTGCTTGATCGAAATCGTCCACAGTGACCTCTTCACACAGCATGACTGCAGAGAGATCCTGCTTCCCATGATGAC
CGATCAGCTCAAGTACCATCTGGAGAGACAGGAGGACCTGGAGGCCTGCTGTCAGCTGCTCAGCCACATCCTGGAGGTGCTGTACAGGAA
GGACGTGGGGCCAACCCAGAGGCACGTCCAGATTATCATGGAGAAACTTCTCCGGACCGTGAACCGAACCGTCATTTCCATGGGACGAGA
TTCTGAACTCATTGACCCATGCCCCCTTTGTGATGAAGCCAAGGAAGTACTCAAGCCTTATGAAAACAGGAGAAGCACTTCACAGTCACT
GGGCAATGCCATTTATAGGAAGAAGGTTCTGCATTCCTGCTGCTGCCCCGGAGGGCTTAACTTTTTAATGAAAGAATAAATGCTCTTCCA

>23757_23757_5_DOCK1-C5orf63_DOCK1_chr10_128926028_ENST00000280333_C5orf63_chr5_126388361_ENST00000607731_length(amino acids)=1006AA_BP=953
MSRLERNGKWRPRRGVSCPTRGGSGGAMTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPAS
YIHLKEAIVEGKGQHETVIPGDLPLIQEVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKI
DYGNRILDLDLVVRDEDGNILDPELTSTISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVL
MSLYDPVESKFISENYLVRWSSSGLPKDIDRLHNLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDNNTRKLTSGLRRPFGVAVMDVT
DIINGKVDDEDKQHFIPFQPVAGENDFLQTVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEIIMPGD
VRNDIYVTLVQGDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWFETVKVAIPIEDVNRSHLRFTF
RHRSSQDSKDKSEKIFALAFVKLMRYDGTTLRDGEHDLIVYKAEAKKLEDAATYLSLPSTKAELEEKGHSATGKSMQSLGSCTISKDSFQ
ISTLVCSTKLTQNVDLLGLLKWRSNTSLLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSESETFDTLVFDALVFIIGLIADRKFQH
FNPVLETYIKKHFSATLAYTKLTKVLKNYVDGAEKPGVNEQLYKAMKALESIFKFIVRSRILFNQLYENKGEADFVESLLQLFRSINDMM
SSMSDQTVRVKGAALKYLPTIVNDVKLVFDPKELSKMFTEFILNVPMGLLTIQKLYCLIEIVHSDLFTQHDCREILLPMMTDQLKYHLER
QEDLEACCQLLSHILEVLYRKDVGPTQRHVQIIMEKLLRTVNRTVISMGRDSELIDPCPLCDEAKEVLKPYENRRSTSQSLGNAIYRKKV

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Fusion Gene PPI Analysis for DOCK1-C5orf63


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDOCK1chr10:128926028chr5:126388361ENST00000280333+27521837_1852928.01866.0NCK2 (minor)
HgeneDOCK1chr10:128926028chr5:126388361ENST00000280333+27521793_1819928.01866.0NCK2 second and third SH3 domain (minor)
HgeneDOCK1chr10:128926028chr5:126388361ENST00000280333+27521820_1836928.01866.0NCK2 third SH3 domain (major)


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DOCK1-C5orf63


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DOCK1-C5orf63


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDOCK1C0013146Drug abuse1CTD_human
HgeneDOCK1C0013170Drug habituation1CTD_human
HgeneDOCK1C0013222Drug Use Disorders1CTD_human
HgeneDOCK1C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneDOCK1C0038580Substance Dependence1CTD_human
HgeneDOCK1C0038586Substance Use Disorders1CTD_human
HgeneDOCK1C0236969Substance-Related Disorders1CTD_human
HgeneDOCK1C0740858Substance abuse problem1CTD_human
HgeneDOCK1C1510472Drug Dependence1CTD_human
HgeneDOCK1C4316881Prescription Drug Abuse1CTD_human
TgeneC0013146Drug abuse1CTD_human
TgeneC0013170Drug habituation1CTD_human
TgeneC0013222Drug Use Disorders1CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneC0038580Substance Dependence1CTD_human
TgeneC0038586Substance Use Disorders1CTD_human
TgeneC0236969Substance-Related Disorders1CTD_human
TgeneC0740858Substance abuse problem1CTD_human
TgeneC1510472Drug Dependence1CTD_human
TgeneC4316881Prescription Drug Abuse1CTD_human