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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DSC3-ATG10 (FusionGDB2 ID:HG1825TG83734)

Fusion Gene Summary for DSC3-ATG10

check button Fusion gene summary
Fusion gene informationFusion gene name: DSC3-ATG10
Fusion gene ID: hg1825tg83734
HgeneTgene
Gene symbol

DSC3

ATG10

Gene ID

1825

83734

Gene namedesmocollin 3autophagy related 10
SynonymsCDHF3|DSC|DSC1|DSC2|DSC4|HT-CPAPG10|APG10L|pp12616
Cytomap('DSC3')('ATG10')

18q12.1

5q14.1-q14.2

Type of geneprotein-codingprotein-coding
Descriptiondesmocollin-3cadherin family member 3desmocollin-4ubiquitin-like-conjugating enzyme ATG10APG10 autophagy 10-likeATG10 autophagy related 10 homologautophagy-related protein 10
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000360428, ENST00000434452, 
Fusion gene scores* DoF score6 X 7 X 4=16810 X 9 X 7=630
# samples 611
** MAII scorelog2(6/168*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DSC3 [Title/Abstract] AND ATG10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDSC3(28598036)-ATG10(81354313), # samples:2
Anticipated loss of major functional domain due to fusion event.DSC3-ATG10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DSC3-ATG10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DSC3-ATG10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DSC3-ATG10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATG10

GO:0032446

protein modification by small protein conjugation

16963840


check buttonFusion gene breakpoints across DSC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ATG10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A8I0DSC3chr18

28598036

-ATG10chr5

81354313

+


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Fusion Gene ORF analysis for DSC3-ATG10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000360428ENST00000514253DSC3chr18

28598036

-ATG10chr5

81354313

+
5CDS-intronENST00000434452ENST00000514253DSC3chr18

28598036

-ATG10chr5

81354313

+
In-frameENST00000360428ENST00000282185DSC3chr18

28598036

-ATG10chr5

81354313

+
In-frameENST00000360428ENST00000355178DSC3chr18

28598036

-ATG10chr5

81354313

+
In-frameENST00000360428ENST00000458350DSC3chr18

28598036

-ATG10chr5

81354313

+
In-frameENST00000360428ENST00000513443DSC3chr18

28598036

-ATG10chr5

81354313

+
In-frameENST00000360428ENST00000513634DSC3chr18

28598036

-ATG10chr5

81354313

+
In-frameENST00000434452ENST00000282185DSC3chr18

28598036

-ATG10chr5

81354313

+
In-frameENST00000434452ENST00000355178DSC3chr18

28598036

-ATG10chr5

81354313

+
In-frameENST00000434452ENST00000458350DSC3chr18

28598036

-ATG10chr5

81354313

+
In-frameENST00000434452ENST00000513443DSC3chr18

28598036

-ATG10chr5

81354313

+
In-frameENST00000434452ENST00000513634DSC3chr18

28598036

-ATG10chr5

81354313

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000360428DSC3chr1828598036-ENST00000355178ATG10chr581354313+2380134491613534
ENST00000360428DSC3chr1828598036-ENST00000282185ATG10chr581354313+3975134491898629
ENST00000360428DSC3chr1828598036-ENST00000458350ATG10chr581354313+2628134491898629
ENST00000360428DSC3chr1828598036-ENST00000513443ATG10chr581354313+1767134491613534
ENST00000360428DSC3chr1828598036-ENST00000513634ATG10chr581354313+1841134491790593
ENST00000434452DSC3chr1828598036-ENST00000355178ATG10chr581354313+24541418831687534
ENST00000434452DSC3chr1828598036-ENST00000282185ATG10chr581354313+40491418831972629
ENST00000434452DSC3chr1828598036-ENST00000458350ATG10chr581354313+27021418831972629
ENST00000434452DSC3chr1828598036-ENST00000513443ATG10chr581354313+18411418831687534
ENST00000434452DSC3chr1828598036-ENST00000513634ATG10chr581354313+19151418831864593

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360428ENST00000355178DSC3chr1828598036-ATG10chr581354313+0.0005493190.9994506
ENST00000360428ENST00000282185DSC3chr1828598036-ATG10chr581354313+0.0001708720.99982905
ENST00000360428ENST00000458350DSC3chr1828598036-ATG10chr581354313+0.0003507340.9996493
ENST00000360428ENST00000513443DSC3chr1828598036-ATG10chr581354313+0.0004240580.9995759
ENST00000360428ENST00000513634DSC3chr1828598036-ATG10chr581354313+0.0004515440.9995484
ENST00000434452ENST00000355178DSC3chr1828598036-ATG10chr581354313+0.0006411010.99935895
ENST00000434452ENST00000282185DSC3chr1828598036-ATG10chr581354313+0.0001857790.9998142
ENST00000434452ENST00000458350DSC3chr1828598036-ATG10chr581354313+0.0004153230.99958473
ENST00000434452ENST00000513443DSC3chr1828598036-ATG10chr581354313+0.0005082110.9994918
ENST00000434452ENST00000513634DSC3chr1828598036-ATG10chr581354313+0.0005454280.99945456

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Fusion Genomic Features for DSC3-ATG10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DSC3chr1828598036-ATG10chr581354313+5.53E-050.9999447
DSC3chr1828598036-ATG10chr581354313+5.53E-050.9999447

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DSC3-ATG10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:28598036/chr5:81354313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSC3chr18:28598036chr5:81354313ENST00000360428-916136_243421897.0DomainCadherin 1
HgeneDSC3chr18:28598036chr5:81354313ENST00000360428-916244_355421897.0DomainCadherin 2
HgeneDSC3chr18:28598036chr5:81354313ENST00000434452-917136_2434212180.3333333333335DomainCadherin 1
HgeneDSC3chr18:28598036chr5:81354313ENST00000434452-917244_3554212180.3333333333335DomainCadherin 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSC3chr18:28598036chr5:81354313ENST00000360428-916356_471421897.0DomainCadherin 3
HgeneDSC3chr18:28598036chr5:81354313ENST00000360428-916472_579421897.0DomainCadherin 4
HgeneDSC3chr18:28598036chr5:81354313ENST00000360428-916580_690421897.0DomainCadherin 5
HgeneDSC3chr18:28598036chr5:81354313ENST00000434452-917356_4714212180.3333333333335DomainCadherin 3
HgeneDSC3chr18:28598036chr5:81354313ENST00000434452-917472_5794212180.3333333333335DomainCadherin 4
HgeneDSC3chr18:28598036chr5:81354313ENST00000434452-917580_6904212180.3333333333335DomainCadherin 5
HgeneDSC3chr18:28598036chr5:81354313ENST00000360428-916136_690421897.0Topological domainExtracellular
HgeneDSC3chr18:28598036chr5:81354313ENST00000360428-916712_896421897.0Topological domainCytoplasmic
HgeneDSC3chr18:28598036chr5:81354313ENST00000434452-917136_6904212180.3333333333335Topological domainExtracellular
HgeneDSC3chr18:28598036chr5:81354313ENST00000434452-917712_8964212180.3333333333335Topological domainCytoplasmic
HgeneDSC3chr18:28598036chr5:81354313ENST00000360428-916691_711421897.0TransmembraneHelical
HgeneDSC3chr18:28598036chr5:81354313ENST00000434452-917691_7114212180.3333333333335TransmembraneHelical


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Fusion Gene Sequence for DSC3-ATG10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24184_24184_1_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000282185_length(transcript)=3975nt_BP=1344nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGT
TCTGATGGCTACATGTGCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGT
CTTCCCATGGAGGAGGCTTTCGAGCTACCCTTGGATGATTGTGAAGTGATTGAAACTGCAGCAGCGTCCGAAGTGATTAAATATGAGTAT
CATGTCTTATATTCCTGTAGCTACCAAGTGCCTGTACTTTACTTTAGGGCAAGCTTTTTAGATGGGAGACCTTTAACTCTGAAGGACATA
TGGGAAGGAGTTCATGAGTGCTATAAGATGCGACTGCTACAGGGACCATGGGACACTATTACGCAACAGGAACATCCAATACTTGGGCAA
CCCTTTTTTGTACTTCATCCCTGCAAGACGAATGAATTCATGACTCCTGTATTAAAGAATTCTCAGAAAATCAATAAGAATGTCAACTAT
ATCACATCATGGCTGAGCATTGTAGGGCCAGTTGTTGGGCTGAATCTACCTCTGAGTTATGCCAAAGCAACGTCTCAGGATGAACGAAAT
GTCCCTTAACAAGATTCTTCTATTGAGTTTAGGAATTGCGGCACGAAGAATGCCAAGAGTTTACCTGGCCAGCCCTGGCTTTAATAGGAC
TGATACCATGGAATATTTCATCTCACCAAGATGTGACATGGATTATTTTTCCCTTGGACACAAATGTCTACAGCAACTGGTGTTTGATAG
GCTGAATGTTTAGAAGAAACACTTCAAAGGGATACATCATGGCCAGGCATGGTGGCTCACACCTGTAATCCAAGCACTTTGGGAGGCCAA
GGTGGGAGCATCACTTGATCCTGGGAGTTCGAGACCAGCCTGGGCAACATGGTGAAACCCTGTCGGTACAAAAAAATACAAAAATTTGCC
TGTTTATGGTGGTGTGTTCCTGTAGTCCCAGCTCCCCAGGAGGCTGAGGTGGGAGGTTGGCTTTAACCCAGGAGGCAGAGGTTGCAGTGA
GCTGAGACTGTGCCACTGCAGTCCAGCCTGGGTGACAGAGCCAGACACTGTCTCGGGGAAAAAAAAAAAAAAAAAAAGACACATCACTAT
AAATAGCAAAAAAACAAATCTAACTTATTAATACTAGGAATACCAACATTATTAGGGCACTTGCAGGTTATTCTTTTCTAGGCCAAGTAC
TTCACTTCCATTTGTCTGACATGGAGATTGAGGGAGAAATGTATTTGTGTGTTCATTTTAATGTAAGATATATAAAAATTAAATTACTGG
ATTTACCTGTCCCTGAAACTGGTGTTATAAACATGACCTATCTTAAGTGATTTTCCCACAATCAAACTCAGGAACAATAGATTATTTCTG
TTTTACTCCAAAAGAGAGAGAGAGAGTGAGTGTGAGTGTGTGTGTGTGTGTGTGTGTATGTGTGGGTGTTTGTGTAGATAGTTGTAAAAC
AAAGAAAAAACACAATATTTTACTGTGAGATAATATGTTTTACCAGCAAAGTGTGGCATAGTAATTAGAAGTTTTCTAAAAAGCTATAGG
AGATATTTAAACATTAAAATTTCTTTTTGACCTATAGTAATAAAACAATGGTCATTTTACCCCTCTGCTTCTCAACCCCACAGCTGCTCT
GCTGTACTCTTTGAGGGCTCTTGAGCGAGTCTTCATGTCCCTGAGACTTATTTTCCTCATCTTTAATTTGAAACTAACAAGCTACCTCAT
AGGGTTGCTGTGAGAACCACATGAGATCATTAATGCATGATAAGATATTGTAAAGTATTATACGAATATTCATTAAATGCTCACCTTTCT
TGTATATAATTGGTATTCACTAAGGCTGTAAATAAGTTTCATAGCCAGTTAAGTATTAAGATAAACCTAACCTGGAACAATTTTTTTTTT
GGTTGCTTGTTTTGTTTTTTGCTTTCATTTGCTAGGAGCTGAAACGAAGATTAAAATGTCATTGGCTTTTTAGAGAGTCTAGATTAGTGT
GTCTTTGAATGAGGGATATACTTAAAATCACCTGAGGATCGTTTACAGCTACAGATGCTGGGGCCACCTGACACAGTCTCTCTGGGGGTG
ATTCTGCTCTGGAGAACCTCTGGTCTGGATATACCTTTATTGTGACATTGATTTGTATTGTTTTGCTCTACTGACAGGCCTTTTCCAATC
CATACAAGCTGAACTTGCTTCCTAATGTTTGTCTAGGCCTTACATGGATAGTAAGGAAGCTTAGGAGACATGTACACAAGGCAGCCCACT
TGTAGGAAACTGCTTCAGGTGAGGACATCATTCACCAGTGGATCACCGAGCACCGTGACAGCACCCTCAGTCCACGTCTGCAGATTAAGA
GCTGAACTCTCACAGAGAAAGTGGAAGTAGAGAAAGGGTTAATTCAAACTGCTAGAAAAGCTAAAAGTAAATTTTAAAATGCTGAGCTGC
CCATATTCATGCTAGGATGAGAGCCGGCTTAAATGCTTGCTGGGCATTTTGGTATTTACCACTTAGCATGTTTTCAACTTCTGTGAGGGA
TTTTCCCCCCAATCTCCCTAATGTAAACACAGATTTCTCAGCAAGTCATTTCTCAAGCCATGTCATTTCTAGTGTAAAATAAATTATAAT

>24184_24184_1_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000282185_length(amino acids)=629AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKDIWEG

--------------------------------------------------------------
>24184_24184_2_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000355178_length(transcript)=2380nt_BP=1344nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGT
TCTGATGGCTACATGTGCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGT
CTTCCCATGGAGGTGAAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTTGCGTGATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTC
AAGCAGTTCTCCTGCCTCAGCCTTCCGAGTAACTGGGACTACAGGGGTTCACCACTACACCTGGCTAATTTTTTGTATTTTTAGTAGAGA
TAAGGTTTCACCATGTTGGTCAGGCTGGTCTTGAACTCCTGACATCAAGTAATCCATCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAG
GCATGAGCCACTGTGCCTGGCCCTGAGCTTAAAATAAAAGTTAAATTAAAAAAAAAATAATGTTGATGTTTTCATTTTTGCAATCAATAG
CTTAGTTAGACTCAAATTGCAAACTGTCATTGCCTGTAGTAGGCAGTGGCATAGAACTCAATTCAGCTCTTTTAACCTGAGTTTTAAGCT
GCTTTCAGATTGCCCCACACATACATGGTTCAGGAGTCAGCCAGAGACTTGGGCTGAGTTTAAACATAGAATCTGGGGTTGTCCTCTTCT
GGCTGTCTTCTTTCTTGGGCATCTGCATCATTCTCTAGCACCTATGGTTTTTCCAGGCTCTTTCCCCCAGTTTCCTCCAGTCAGAAAGAT
GGCAAGAGTTTTTGCTGCCTGCCCTCCCCCAGTCCTTGTGCCAACACCACCACCATTGCAGCTGCCTCCAGGGAAAAACTGCAAAAACCA
AATCACTTGCTCCAGGTGTTGACTCCTCTTCAAAATCTATTTTTGTTAAATCTCCAAAGCCTCAAATAGGTTTTCTTCCTAGAATTTATA
TCTGTTATTTGTAGCAGGATTGGTCTGTAAGGCACTCAGTCTTCTACATCATGGGTCAGCAGATTACAGCCCTTGGGTTAAATCCAGCCA

>24184_24184_2_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000355178_length(amino acids)=534AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG

--------------------------------------------------------------
>24184_24184_3_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000458350_length(transcript)=2628nt_BP=1344nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGT
TCTGATGGCTACATGTGCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGT
CTTCCCATGGAGGAGGCTTTCGAGCTACCCTTGGATGATTGTGAAGTGATTGAAACTGCAGCAGCGTCCGAAGTGATTAAATATGAGTAT
CATGTCTTATATTCCTGTAGCTACCAAGTGCCTGTACTTTACTTTAGGGCAAGCTTTTTAGATGGGAGACCTTTAACTCTGAAGGACATA
TGGGAAGGAGTTCATGAGTGCTATAAGATGCGACTGCTACAGGGACCATGGGACACTATTACGCAACAGGAACATCCAATACTTGGGCAA
CCCTTTTTTGTACTTCATCCCTGCAAGACGAATGAATTCATGACTCCTGTATTAAAGAATTCTCAGAAAATCAATAAGAATGTCAACTAT
ATCACATCATGGCTGAGCATTGTAGGGCCAGTTGTTGGGCTGAATCTACCTCTGAGTTATGCCAAAGCAACGTCTCAGGATGAACGAAAT
GTCCCTTAACAAGATTCTTCTATTGAGTTTAGGAATTGCGGCACGAAGAATGCCAAGAGTTTACCTGGCCAGCCCTGGCTTTAATAGGAC
TGATACCATGGAATATTTCATCTCACCAAGATGTGACATGGATTATTTTTCCCTTGGACACAAATGTCTACAGCAACTGGTGTTTGATAG
GCTGAATGTTTAGAAGAAACACTTCAAAGGGATACATCATGGCCAGGCATGGTGGCTCACACCTGTAATCCAAGCACTTTGGGAGGCCAA
GGTGGGAGCATCACTTGATCCTGGGAGTTCGAGACCAGCCTGGGCAACATGGTGAAACCCTGTCGGTACAAAAAAATACAAAAATTTGCC
TGTTTATGGTGGTGTGTTCCTGTAGTCCCAGCTCCCCAGGAGGCTGAGGTGGGAGGTTGGCTTTAACCCAGGAGGCAGAGGTTGCAGTGA
GCTGAGACTGTGCCACTGCAGTCCAGCCTGGGTGACAGAGCCAGACACTGTCTCGGGGAAAAAAAAAAAAAAAAAAAGACACATCACTAT
AAATAGCAAAAAAACAAATCTAACTTATTAATACTAGGAATACCAACATTATTAGGGCACTTGCAGGTTATTCTTTTCTAGGCCAAGTAC
TTCACTTCCATTTGTCTGACATGGAGATTGAGGGAGAAATGTATTTGTGTGTTCATTTTAATGTAAGATATATAAAAATTAAATTACTGG

>24184_24184_3_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000458350_length(amino acids)=629AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKDIWEG

--------------------------------------------------------------
>24184_24184_4_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000513443_length(transcript)=1767nt_BP=1344nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGT
TCTGATGGCTACATGTGCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGT
CTTCCCATGGAGGTGAAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTTGCGTGATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTC
AAGCAGTTCTCCTGCCTCAGCCTTCCGAGTAACTGGGACTACAGGGGTTCACCACTACACCTGGCTAATTTTTTGTATTTTTAGTAGAGA
TAAGGTTTCACCATGTTGGTCAGGCTGGTCTTGAACTCCTGACATCAAGTAATCCATCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAG

>24184_24184_4_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000513443_length(amino acids)=534AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG

--------------------------------------------------------------
>24184_24184_5_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000513634_length(transcript)=1841nt_BP=1344nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGT
TCTGATGGCTACATGTGCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGT
CTTCCCATGGAGGAGGCTTTCGAGCTACCCTTGGATGATTGTGAAGTGATTGAAACTGCAGCAGCGTCCGAAGTGATTAAATATGAGTAT
CATGTCTTATATTCCTGTAGCTACCAAGTGCCTGTACTTTACTTTAGGGCAAGCTTTTTAGATGGGAGACCTTTAACTCTGAAGGACATA
TGGGAAGGAGTTCATGAGTGCTATAAGATGCGACTGCTACAGGGACCATGGGACACTATTACGCAACAGGAACATCCAATACTTGGGCAA
CCCTTTTTTGTACTTCATCCCTGCAAGACGAATGAATTCATGACTCCTGTATTAAAGAATTCTCAGAAAATCAATAAGTAAGAAACACCA

>24184_24184_5_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000513634_length(amino acids)=593AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKDIWEG

--------------------------------------------------------------
>24184_24184_6_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000282185_length(transcript)=4049nt_BP=1418nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGTTCTGATGGCTACATGT
GCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGTCTTCCCATGGAGGAGG
CTTTCGAGCTACCCTTGGATGATTGTGAAGTGATTGAAACTGCAGCAGCGTCCGAAGTGATTAAATATGAGTATCATGTCTTATATTCCT
GTAGCTACCAAGTGCCTGTACTTTACTTTAGGGCAAGCTTTTTAGATGGGAGACCTTTAACTCTGAAGGACATATGGGAAGGAGTTCATG
AGTGCTATAAGATGCGACTGCTACAGGGACCATGGGACACTATTACGCAACAGGAACATCCAATACTTGGGCAACCCTTTTTTGTACTTC
ATCCCTGCAAGACGAATGAATTCATGACTCCTGTATTAAAGAATTCTCAGAAAATCAATAAGAATGTCAACTATATCACATCATGGCTGA
GCATTGTAGGGCCAGTTGTTGGGCTGAATCTACCTCTGAGTTATGCCAAAGCAACGTCTCAGGATGAACGAAATGTCCCTTAACAAGATT
CTTCTATTGAGTTTAGGAATTGCGGCACGAAGAATGCCAAGAGTTTACCTGGCCAGCCCTGGCTTTAATAGGACTGATACCATGGAATAT
TTCATCTCACCAAGATGTGACATGGATTATTTTTCCCTTGGACACAAATGTCTACAGCAACTGGTGTTTGATAGGCTGAATGTTTAGAAG
AAACACTTCAAAGGGATACATCATGGCCAGGCATGGTGGCTCACACCTGTAATCCAAGCACTTTGGGAGGCCAAGGTGGGAGCATCACTT
GATCCTGGGAGTTCGAGACCAGCCTGGGCAACATGGTGAAACCCTGTCGGTACAAAAAAATACAAAAATTTGCCTGTTTATGGTGGTGTG
TTCCTGTAGTCCCAGCTCCCCAGGAGGCTGAGGTGGGAGGTTGGCTTTAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGACTGTGCCAC
TGCAGTCCAGCCTGGGTGACAGAGCCAGACACTGTCTCGGGGAAAAAAAAAAAAAAAAAAAGACACATCACTATAAATAGCAAAAAAACA
AATCTAACTTATTAATACTAGGAATACCAACATTATTAGGGCACTTGCAGGTTATTCTTTTCTAGGCCAAGTACTTCACTTCCATTTGTC
TGACATGGAGATTGAGGGAGAAATGTATTTGTGTGTTCATTTTAATGTAAGATATATAAAAATTAAATTACTGGATTTACCTGTCCCTGA
AACTGGTGTTATAAACATGACCTATCTTAAGTGATTTTCCCACAATCAAACTCAGGAACAATAGATTATTTCTGTTTTACTCCAAAAGAG
AGAGAGAGAGTGAGTGTGAGTGTGTGTGTGTGTGTGTGTGTATGTGTGGGTGTTTGTGTAGATAGTTGTAAAACAAAGAAAAAACACAAT
ATTTTACTGTGAGATAATATGTTTTACCAGCAAAGTGTGGCATAGTAATTAGAAGTTTTCTAAAAAGCTATAGGAGATATTTAAACATTA
AAATTTCTTTTTGACCTATAGTAATAAAACAATGGTCATTTTACCCCTCTGCTTCTCAACCCCACAGCTGCTCTGCTGTACTCTTTGAGG
GCTCTTGAGCGAGTCTTCATGTCCCTGAGACTTATTTTCCTCATCTTTAATTTGAAACTAACAAGCTACCTCATAGGGTTGCTGTGAGAA
CCACATGAGATCATTAATGCATGATAAGATATTGTAAAGTATTATACGAATATTCATTAAATGCTCACCTTTCTTGTATATAATTGGTAT
TCACTAAGGCTGTAAATAAGTTTCATAGCCAGTTAAGTATTAAGATAAACCTAACCTGGAACAATTTTTTTTTTGGTTGCTTGTTTTGTT
TTTTGCTTTCATTTGCTAGGAGCTGAAACGAAGATTAAAATGTCATTGGCTTTTTAGAGAGTCTAGATTAGTGTGTCTTTGAATGAGGGA
TATACTTAAAATCACCTGAGGATCGTTTACAGCTACAGATGCTGGGGCCACCTGACACAGTCTCTCTGGGGGTGATTCTGCTCTGGAGAA
CCTCTGGTCTGGATATACCTTTATTGTGACATTGATTTGTATTGTTTTGCTCTACTGACAGGCCTTTTCCAATCCATACAAGCTGAACTT
GCTTCCTAATGTTTGTCTAGGCCTTACATGGATAGTAAGGAAGCTTAGGAGACATGTACACAAGGCAGCCCACTTGTAGGAAACTGCTTC
AGGTGAGGACATCATTCACCAGTGGATCACCGAGCACCGTGACAGCACCCTCAGTCCACGTCTGCAGATTAAGAGCTGAACTCTCACAGA
GAAAGTGGAAGTAGAGAAAGGGTTAATTCAAACTGCTAGAAAAGCTAAAAGTAAATTTTAAAATGCTGAGCTGCCCATATTCATGCTAGG
ATGAGAGCCGGCTTAAATGCTTGCTGGGCATTTTGGTATTTACCACTTAGCATGTTTTCAACTTCTGTGAGGGATTTTCCCCCCAATCTC

>24184_24184_6_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000282185_length(amino acids)=629AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKDIWEG

--------------------------------------------------------------
>24184_24184_7_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000355178_length(transcript)=2454nt_BP=1418nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGTTCTGATGGCTACATGT
GCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGTCTTCCCATGGAGGTGA
AGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTTGCGTGATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTCAAGCAGTTCTCCTGCC
TCAGCCTTCCGAGTAACTGGGACTACAGGGGTTCACCACTACACCTGGCTAATTTTTTGTATTTTTAGTAGAGATAAGGTTTCACCATGT
TGGTCAGGCTGGTCTTGAACTCCTGACATCAAGTAATCCATCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAGGCATGAGCCACTGTGC
CTGGCCCTGAGCTTAAAATAAAAGTTAAATTAAAAAAAAAATAATGTTGATGTTTTCATTTTTGCAATCAATAGCTTAGTTAGACTCAAA
TTGCAAACTGTCATTGCCTGTAGTAGGCAGTGGCATAGAACTCAATTCAGCTCTTTTAACCTGAGTTTTAAGCTGCTTTCAGATTGCCCC
ACACATACATGGTTCAGGAGTCAGCCAGAGACTTGGGCTGAGTTTAAACATAGAATCTGGGGTTGTCCTCTTCTGGCTGTCTTCTTTCTT
GGGCATCTGCATCATTCTCTAGCACCTATGGTTTTTCCAGGCTCTTTCCCCCAGTTTCCTCCAGTCAGAAAGATGGCAAGAGTTTTTGCT
GCCTGCCCTCCCCCAGTCCTTGTGCCAACACCACCACCATTGCAGCTGCCTCCAGGGAAAAACTGCAAAAACCAAATCACTTGCTCCAGG
TGTTGACTCCTCTTCAAAATCTATTTTTGTTAAATCTCCAAAGCCTCAAATAGGTTTTCTTCCTAGAATTTATATCTGTTATTTGTAGCA
GGATTGGTCTGTAAGGCACTCAGTCTTCTACATCATGGGTCAGCAGATTACAGCCCTTGGGTTAAATCCAGCCACCTGCTTGTTTTATTA

>24184_24184_7_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000355178_length(amino acids)=534AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG

--------------------------------------------------------------
>24184_24184_8_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000458350_length(transcript)=2702nt_BP=1418nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGTTCTGATGGCTACATGT
GCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGTCTTCCCATGGAGGAGG
CTTTCGAGCTACCCTTGGATGATTGTGAAGTGATTGAAACTGCAGCAGCGTCCGAAGTGATTAAATATGAGTATCATGTCTTATATTCCT
GTAGCTACCAAGTGCCTGTACTTTACTTTAGGGCAAGCTTTTTAGATGGGAGACCTTTAACTCTGAAGGACATATGGGAAGGAGTTCATG
AGTGCTATAAGATGCGACTGCTACAGGGACCATGGGACACTATTACGCAACAGGAACATCCAATACTTGGGCAACCCTTTTTTGTACTTC
ATCCCTGCAAGACGAATGAATTCATGACTCCTGTATTAAAGAATTCTCAGAAAATCAATAAGAATGTCAACTATATCACATCATGGCTGA
GCATTGTAGGGCCAGTTGTTGGGCTGAATCTACCTCTGAGTTATGCCAAAGCAACGTCTCAGGATGAACGAAATGTCCCTTAACAAGATT
CTTCTATTGAGTTTAGGAATTGCGGCACGAAGAATGCCAAGAGTTTACCTGGCCAGCCCTGGCTTTAATAGGACTGATACCATGGAATAT
TTCATCTCACCAAGATGTGACATGGATTATTTTTCCCTTGGACACAAATGTCTACAGCAACTGGTGTTTGATAGGCTGAATGTTTAGAAG
AAACACTTCAAAGGGATACATCATGGCCAGGCATGGTGGCTCACACCTGTAATCCAAGCACTTTGGGAGGCCAAGGTGGGAGCATCACTT
GATCCTGGGAGTTCGAGACCAGCCTGGGCAACATGGTGAAACCCTGTCGGTACAAAAAAATACAAAAATTTGCCTGTTTATGGTGGTGTG
TTCCTGTAGTCCCAGCTCCCCAGGAGGCTGAGGTGGGAGGTTGGCTTTAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGACTGTGCCAC
TGCAGTCCAGCCTGGGTGACAGAGCCAGACACTGTCTCGGGGAAAAAAAAAAAAAAAAAAAGACACATCACTATAAATAGCAAAAAAACA
AATCTAACTTATTAATACTAGGAATACCAACATTATTAGGGCACTTGCAGGTTATTCTTTTCTAGGCCAAGTACTTCACTTCCATTTGTC
TGACATGGAGATTGAGGGAGAAATGTATTTGTGTGTTCATTTTAATGTAAGATATATAAAAATTAAATTACTGGATTTACCTGTCCCTGA

>24184_24184_8_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000458350_length(amino acids)=629AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKDIWEG

--------------------------------------------------------------
>24184_24184_9_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000513443_length(transcript)=1841nt_BP=1418nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGTTCTGATGGCTACATGT
GCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGTCTTCCCATGGAGGTGA
AGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTTGCGTGATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTCAAGCAGTTCTCCTGCC
TCAGCCTTCCGAGTAACTGGGACTACAGGGGTTCACCACTACACCTGGCTAATTTTTTGTATTTTTAGTAGAGATAAGGTTTCACCATGT
TGGTCAGGCTGGTCTTGAACTCCTGACATCAAGTAATCCATCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAGGCATGAGCCACTGTGC

>24184_24184_9_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000513443_length(amino acids)=534AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG

--------------------------------------------------------------
>24184_24184_10_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000513634_length(transcript)=1915nt_BP=1418nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGTTCTGATGGCTACATGT
GCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGTCTTCCCATGGAGGAGG
CTTTCGAGCTACCCTTGGATGATTGTGAAGTGATTGAAACTGCAGCAGCGTCCGAAGTGATTAAATATGAGTATCATGTCTTATATTCCT
GTAGCTACCAAGTGCCTGTACTTTACTTTAGGGCAAGCTTTTTAGATGGGAGACCTTTAACTCTGAAGGACATATGGGAAGGAGTTCATG
AGTGCTATAAGATGCGACTGCTACAGGGACCATGGGACACTATTACGCAACAGGAACATCCAATACTTGGGCAACCCTTTTTTGTACTTC
ATCCCTGCAAGACGAATGAATTCATGACTCCTGTATTAAAGAATTCTCAGAAAATCAATAAGTAAGAAACACCATCAAGATACATTGGCT

>24184_24184_10_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000513634_length(amino acids)=593AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKDIWEG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DSC3-ATG10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DSC3-ATG10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DSC3-ATG10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDSC3C0006142Malignant neoplasm of breast1CTD_human
HgeneDSC3C0678222Breast Carcinoma1CTD_human
HgeneDSC3C1257931Mammary Neoplasms, Human1CTD_human
HgeneDSC3C1458155Mammary Neoplasms1CTD_human
HgeneDSC3C2751292Hypotrichosis And Recurrent Skin Vesicles1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneDSC3C4704874Mammary Carcinoma, Human1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human