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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DSC3-ATG10 (FusionGDB2 ID:HG1825TG83734)

Fusion Gene Summary for DSC3-ATG10

Fusion gene summary

Fusion gene information	Fusion gene name: DSC3-ATG10
	Fusion gene ID: hg1825tg83734
		Hgene	Tgene
	Gene symbol	DSC3	ATG10
	Gene ID	1825	83734
	Gene name	desmocollin 3	autophagy related 10
	Synonyms	CDHF3\|DSC\|DSC1\|DSC2\|DSC4\|HT-CP	APG10\|APG10L\|pp12616
	Cytomap	('DSC3')('ATG10') 18q12.1	5q14.1-q14.2
	Type of gene	protein-coding	protein-coding
	Description	desmocollin-3cadherin family member 3desmocollin-4	ubiquitin-like-conjugating enzyme ATG10APG10 autophagy 10-likeATG10 autophagy related 10 homologautophagy-related protein 10
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000360428, ENST00000434452,
Fusion gene scores	* DoF score	6 X 7 X 4=168	10 X 9 X 7=630
	# samples	6	11
	** MAII score	log2(6/168*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/630*10)=-2.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DSC3 [Title/Abstract] AND ATG10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DSC3(28598036)-ATG10(81354313), # samples:2
Anticipated loss of major functional domain due to fusion event.	DSC3-ATG10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DSC3-ATG10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DSC3-ATG10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DSC3-ATG10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ATG10	GO:0032446	protein modification by small protein conjugation	16963840

Fusion gene breakpoints across DSC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATG10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-LN-A8I0	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+

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Fusion Gene ORF analysis for DSC3-ATG10

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000360428	ENST00000514253	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+
5CDS-intron	ENST00000434452	ENST00000514253	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+
In-frame	ENST00000360428	ENST00000282185	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+
In-frame	ENST00000360428	ENST00000355178	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+
In-frame	ENST00000360428	ENST00000458350	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+
In-frame	ENST00000360428	ENST00000513443	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+
In-frame	ENST00000360428	ENST00000513634	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+
In-frame	ENST00000434452	ENST00000282185	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+
In-frame	ENST00000434452	ENST00000355178	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+
In-frame	ENST00000434452	ENST00000458350	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+
In-frame	ENST00000434452	ENST00000513443	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+
In-frame	ENST00000434452	ENST00000513634	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000360428	DSC3	chr18	28598036	-	ENST00000355178	ATG10	chr5	81354313	+	2380	1344	9	1613	534
ENST00000360428	DSC3	chr18	28598036	-	ENST00000282185	ATG10	chr5	81354313	+	3975	1344	9	1898	629
ENST00000360428	DSC3	chr18	28598036	-	ENST00000458350	ATG10	chr5	81354313	+	2628	1344	9	1898	629
ENST00000360428	DSC3	chr18	28598036	-	ENST00000513443	ATG10	chr5	81354313	+	1767	1344	9	1613	534
ENST00000360428	DSC3	chr18	28598036	-	ENST00000513634	ATG10	chr5	81354313	+	1841	1344	9	1790	593
ENST00000434452	DSC3	chr18	28598036	-	ENST00000355178	ATG10	chr5	81354313	+	2454	1418	83	1687	534
ENST00000434452	DSC3	chr18	28598036	-	ENST00000282185	ATG10	chr5	81354313	+	4049	1418	83	1972	629
ENST00000434452	DSC3	chr18	28598036	-	ENST00000458350	ATG10	chr5	81354313	+	2702	1418	83	1972	629
ENST00000434452	DSC3	chr18	28598036	-	ENST00000513443	ATG10	chr5	81354313	+	1841	1418	83	1687	534
ENST00000434452	DSC3	chr18	28598036	-	ENST00000513634	ATG10	chr5	81354313	+	1915	1418	83	1864	593

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000360428	ENST00000355178	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+	0.000549319	0.9994506
ENST00000360428	ENST00000282185	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+	0.000170872	0.99982905
ENST00000360428	ENST00000458350	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+	0.000350734	0.9996493
ENST00000360428	ENST00000513443	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+	0.000424058	0.9995759
ENST00000360428	ENST00000513634	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+	0.000451544	0.9995484
ENST00000434452	ENST00000355178	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+	0.000641101	0.99935895
ENST00000434452	ENST00000282185	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+	0.000185779	0.9998142
ENST00000434452	ENST00000458350	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+	0.000415323	0.99958473
ENST00000434452	ENST00000513443	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+	0.000508211	0.9994918
ENST00000434452	ENST00000513634	DSC3	chr18	28598036	-	ATG10	chr5	81354313	+	0.000545428	0.99945456

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Fusion Genomic Features for DSC3-ATG10

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DSC3	chr18	28598036	-	ATG10	chr5	81354313	+	5.53E-05	0.9999447
DSC3	chr18	28598036	-	ATG10	chr5	81354313	+	5.53E-05	0.9999447

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DSC3-ATG10

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:28598036/chr5:81354313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000360428

136_243

421

897.0

Domain

Cadherin 1

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000360428

244_355

421

897.0

Domain

Cadherin 2

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000434452

136_243

421

2180.3333333333335

Domain

Cadherin 1

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000434452

244_355

421

2180.3333333333335

Domain

Cadherin 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000360428

356_471

421

897.0

Domain

Cadherin 3

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000360428

472_579

421

897.0

Domain

Cadherin 4

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000360428

580_690

421

897.0

Domain

Cadherin 5

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000434452

356_471

421

2180.3333333333335

Domain

Cadherin 3

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000434452

472_579

421

2180.3333333333335

Domain

Cadherin 4

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000434452

580_690

421

2180.3333333333335

Domain

Cadherin 5

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000360428

136_690

421

897.0

Topological domain

Extracellular

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000360428

712_896

421

897.0

Topological domain

Cytoplasmic

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000434452

136_690

421

2180.3333333333335

Topological domain

Extracellular

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000434452

712_896

421

2180.3333333333335

Topological domain

Cytoplasmic

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000360428

691_711

421

897.0

Transmembrane

Helical

Hgene

DSC3

chr18:28598036

chr5:81354313

ENST00000434452

691_711

421

2180.3333333333335

Transmembrane

Helical

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Fusion Gene Sequence for DSC3-ATG10

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>24184_24184_1_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000282185_length(transcript)=3975nt_BP=1344nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGT
TCTGATGGCTACATGTGCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGT
CTTCCCATGGAGGAGGCTTTCGAGCTACCCTTGGATGATTGTGAAGTGATTGAAACTGCAGCAGCGTCCGAAGTGATTAAATATGAGTAT
CATGTCTTATATTCCTGTAGCTACCAAGTGCCTGTACTTTACTTTAGGGCAAGCTTTTTAGATGGGAGACCTTTAACTCTGAAGGACATA
TGGGAAGGAGTTCATGAGTGCTATAAGATGCGACTGCTACAGGGACCATGGGACACTATTACGCAACAGGAACATCCAATACTTGGGCAA
CCCTTTTTTGTACTTCATCCCTGCAAGACGAATGAATTCATGACTCCTGTATTAAAGAATTCTCAGAAAATCAATAAGAATGTCAACTAT
ATCACATCATGGCTGAGCATTGTAGGGCCAGTTGTTGGGCTGAATCTACCTCTGAGTTATGCCAAAGCAACGTCTCAGGATGAACGAAAT
GTCCCTTAACAAGATTCTTCTATTGAGTTTAGGAATTGCGGCACGAAGAATGCCAAGAGTTTACCTGGCCAGCCCTGGCTTTAATAGGAC
TGATACCATGGAATATTTCATCTCACCAAGATGTGACATGGATTATTTTTCCCTTGGACACAAATGTCTACAGCAACTGGTGTTTGATAG
GCTGAATGTTTAGAAGAAACACTTCAAAGGGATACATCATGGCCAGGCATGGTGGCTCACACCTGTAATCCAAGCACTTTGGGAGGCCAA
GGTGGGAGCATCACTTGATCCTGGGAGTTCGAGACCAGCCTGGGCAACATGGTGAAACCCTGTCGGTACAAAAAAATACAAAAATTTGCC
TGTTTATGGTGGTGTGTTCCTGTAGTCCCAGCTCCCCAGGAGGCTGAGGTGGGAGGTTGGCTTTAACCCAGGAGGCAGAGGTTGCAGTGA
GCTGAGACTGTGCCACTGCAGTCCAGCCTGGGTGACAGAGCCAGACACTGTCTCGGGGAAAAAAAAAAAAAAAAAAAGACACATCACTAT
AAATAGCAAAAAAACAAATCTAACTTATTAATACTAGGAATACCAACATTATTAGGGCACTTGCAGGTTATTCTTTTCTAGGCCAAGTAC
TTCACTTCCATTTGTCTGACATGGAGATTGAGGGAGAAATGTATTTGTGTGTTCATTTTAATGTAAGATATATAAAAATTAAATTACTGG
ATTTACCTGTCCCTGAAACTGGTGTTATAAACATGACCTATCTTAAGTGATTTTCCCACAATCAAACTCAGGAACAATAGATTATTTCTG
TTTTACTCCAAAAGAGAGAGAGAGAGTGAGTGTGAGTGTGTGTGTGTGTGTGTGTGTATGTGTGGGTGTTTGTGTAGATAGTTGTAAAAC
AAAGAAAAAACACAATATTTTACTGTGAGATAATATGTTTTACCAGCAAAGTGTGGCATAGTAATTAGAAGTTTTCTAAAAAGCTATAGG
AGATATTTAAACATTAAAATTTCTTTTTGACCTATAGTAATAAAACAATGGTCATTTTACCCCTCTGCTTCTCAACCCCACAGCTGCTCT
GCTGTACTCTTTGAGGGCTCTTGAGCGAGTCTTCATGTCCCTGAGACTTATTTTCCTCATCTTTAATTTGAAACTAACAAGCTACCTCAT
AGGGTTGCTGTGAGAACCACATGAGATCATTAATGCATGATAAGATATTGTAAAGTATTATACGAATATTCATTAAATGCTCACCTTTCT
TGTATATAATTGGTATTCACTAAGGCTGTAAATAAGTTTCATAGCCAGTTAAGTATTAAGATAAACCTAACCTGGAACAATTTTTTTTTT
GGTTGCTTGTTTTGTTTTTTGCTTTCATTTGCTAGGAGCTGAAACGAAGATTAAAATGTCATTGGCTTTTTAGAGAGTCTAGATTAGTGT
GTCTTTGAATGAGGGATATACTTAAAATCACCTGAGGATCGTTTACAGCTACAGATGCTGGGGCCACCTGACACAGTCTCTCTGGGGGTG
ATTCTGCTCTGGAGAACCTCTGGTCTGGATATACCTTTATTGTGACATTGATTTGTATTGTTTTGCTCTACTGACAGGCCTTTTCCAATC
CATACAAGCTGAACTTGCTTCCTAATGTTTGTCTAGGCCTTACATGGATAGTAAGGAAGCTTAGGAGACATGTACACAAGGCAGCCCACT
TGTAGGAAACTGCTTCAGGTGAGGACATCATTCACCAGTGGATCACCGAGCACCGTGACAGCACCCTCAGTCCACGTCTGCAGATTAAGA
GCTGAACTCTCACAGAGAAAGTGGAAGTAGAGAAAGGGTTAATTCAAACTGCTAGAAAAGCTAAAAGTAAATTTTAAAATGCTGAGCTGC
CCATATTCATGCTAGGATGAGAGCCGGCTTAAATGCTTGCTGGGCATTTTGGTATTTACCACTTAGCATGTTTTCAACTTCTGTGAGGGA
TTTTCCCCCCAATCTCCCTAATGTAAACACAGATTTCTCAGCAAGTCATTTCTCAAGCCATGTCATTTCTAGTGTAAAATAAATTATAAT
AATGTGTCATCTGAA

>24184_24184_1_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000282185_length(amino acids)=629AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKDIWEG
VHECYKMRLLQGPWDTITQQEHPILGQPFFVLHPCKTNEFMTPVLKNSQKINKNVNYITSWLSIVGPVVGLNLPLSYAKATSQDERNVP

--------------------------------------------------------------
>24184_24184_2_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000355178_length(transcript)=2380nt_BP=1344nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGT
TCTGATGGCTACATGTGCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGT
CTTCCCATGGAGGTGAAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTTGCGTGATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTC
AAGCAGTTCTCCTGCCTCAGCCTTCCGAGTAACTGGGACTACAGGGGTTCACCACTACACCTGGCTAATTTTTTGTATTTTTAGTAGAGA
TAAGGTTTCACCATGTTGGTCAGGCTGGTCTTGAACTCCTGACATCAAGTAATCCATCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAG
GCATGAGCCACTGTGCCTGGCCCTGAGCTTAAAATAAAAGTTAAATTAAAAAAAAAATAATGTTGATGTTTTCATTTTTGCAATCAATAG
CTTAGTTAGACTCAAATTGCAAACTGTCATTGCCTGTAGTAGGCAGTGGCATAGAACTCAATTCAGCTCTTTTAACCTGAGTTTTAAGCT
GCTTTCAGATTGCCCCACACATACATGGTTCAGGAGTCAGCCAGAGACTTGGGCTGAGTTTAAACATAGAATCTGGGGTTGTCCTCTTCT
GGCTGTCTTCTTTCTTGGGCATCTGCATCATTCTCTAGCACCTATGGTTTTTCCAGGCTCTTTCCCCCAGTTTCCTCCAGTCAGAAAGAT
GGCAAGAGTTTTTGCTGCCTGCCCTCCCCCAGTCCTTGTGCCAACACCACCACCATTGCAGCTGCCTCCAGGGAAAAACTGCAAAAACCA
AATCACTTGCTCCAGGTGTTGACTCCTCTTCAAAATCTATTTTTGTTAAATCTCCAAAGCCTCAAATAGGTTTTCTTCCTAGAATTTATA
TCTGTTATTTGTAGCAGGATTGGTCTGTAAGGCACTCAGTCTTCTACATCATGGGTCAGCAGATTACAGCCCTTGGGTTAAATCCAGCCA
CCTGCTTGTTTTATTAATAAAGTTTTGTTGGAACTAAACC

>24184_24184_2_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000355178_length(amino acids)=534AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEVKSCSVTQAGVQLRDLSSLQPPPSGFKQFSCLSLPSNWDYRGSPLHLANFLYF

--------------------------------------------------------------
>24184_24184_3_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000458350_length(transcript)=2628nt_BP=1344nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGT
TCTGATGGCTACATGTGCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGT
CTTCCCATGGAGGAGGCTTTCGAGCTACCCTTGGATGATTGTGAAGTGATTGAAACTGCAGCAGCGTCCGAAGTGATTAAATATGAGTAT
CATGTCTTATATTCCTGTAGCTACCAAGTGCCTGTACTTTACTTTAGGGCAAGCTTTTTAGATGGGAGACCTTTAACTCTGAAGGACATA
TGGGAAGGAGTTCATGAGTGCTATAAGATGCGACTGCTACAGGGACCATGGGACACTATTACGCAACAGGAACATCCAATACTTGGGCAA
CCCTTTTTTGTACTTCATCCCTGCAAGACGAATGAATTCATGACTCCTGTATTAAAGAATTCTCAGAAAATCAATAAGAATGTCAACTAT
ATCACATCATGGCTGAGCATTGTAGGGCCAGTTGTTGGGCTGAATCTACCTCTGAGTTATGCCAAAGCAACGTCTCAGGATGAACGAAAT
GTCCCTTAACAAGATTCTTCTATTGAGTTTAGGAATTGCGGCACGAAGAATGCCAAGAGTTTACCTGGCCAGCCCTGGCTTTAATAGGAC
TGATACCATGGAATATTTCATCTCACCAAGATGTGACATGGATTATTTTTCCCTTGGACACAAATGTCTACAGCAACTGGTGTTTGATAG
GCTGAATGTTTAGAAGAAACACTTCAAAGGGATACATCATGGCCAGGCATGGTGGCTCACACCTGTAATCCAAGCACTTTGGGAGGCCAA
GGTGGGAGCATCACTTGATCCTGGGAGTTCGAGACCAGCCTGGGCAACATGGTGAAACCCTGTCGGTACAAAAAAATACAAAAATTTGCC
TGTTTATGGTGGTGTGTTCCTGTAGTCCCAGCTCCCCAGGAGGCTGAGGTGGGAGGTTGGCTTTAACCCAGGAGGCAGAGGTTGCAGTGA
GCTGAGACTGTGCCACTGCAGTCCAGCCTGGGTGACAGAGCCAGACACTGTCTCGGGGAAAAAAAAAAAAAAAAAAAGACACATCACTAT
AAATAGCAAAAAAACAAATCTAACTTATTAATACTAGGAATACCAACATTATTAGGGCACTTGCAGGTTATTCTTTTCTAGGCCAAGTAC
TTCACTTCCATTTGTCTGACATGGAGATTGAGGGAGAAATGTATTTGTGTGTTCATTTTAATGTAAGATATATAAAAATTAAATTACTGG
ATTTACCTGTCCCTGAAA

>24184_24184_3_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000458350_length(amino acids)=629AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKDIWEG
VHECYKMRLLQGPWDTITQQEHPILGQPFFVLHPCKTNEFMTPVLKNSQKINKNVNYITSWLSIVGPVVGLNLPLSYAKATSQDERNVP

--------------------------------------------------------------
>24184_24184_4_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000513443_length(transcript)=1767nt_BP=1344nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGT
TCTGATGGCTACATGTGCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGT
CTTCCCATGGAGGTGAAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTTGCGTGATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTC
AAGCAGTTCTCCTGCCTCAGCCTTCCGAGTAACTGGGACTACAGGGGTTCACCACTACACCTGGCTAATTTTTTGTATTTTTAGTAGAGA
TAAGGTTTCACCATGTTGGTCAGGCTGGTCTTGAACTCCTGACATCAAGTAATCCATCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAG
GCATGAGCCACTGTGCCTGGCCCTGAGCTTAAAATAAAAGTTAAATTAAAAAAAAAA

>24184_24184_4_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000513443_length(amino acids)=534AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEVKSCSVTQAGVQLRDLSSLQPPPSGFKQFSCLSLPSNWDYRGSPLHLANFLYF

--------------------------------------------------------------
>24184_24184_5_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000513634_length(transcript)=1841nt_BP=1344nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGT
TCTGATGGCTACATGTGCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGT
CTTCCCATGGAGGAGGCTTTCGAGCTACCCTTGGATGATTGTGAAGTGATTGAAACTGCAGCAGCGTCCGAAGTGATTAAATATGAGTAT
CATGTCTTATATTCCTGTAGCTACCAAGTGCCTGTACTTTACTTTAGGGCAAGCTTTTTAGATGGGAGACCTTTAACTCTGAAGGACATA
TGGGAAGGAGTTCATGAGTGCTATAAGATGCGACTGCTACAGGGACCATGGGACACTATTACGCAACAGGAACATCCAATACTTGGGCAA
CCCTTTTTTGTACTTCATCCCTGCAAGACGAATGAATTCATGACTCCTGTATTAAAGAATTCTCAGAAAATCAATAAGTAAGAAACACCA
TCAAGATACATTGGCTTCTACTCTGATTTTAAAAGTGTAAA

>24184_24184_5_DSC3-ATG10_DSC3_chr18_28598036_ENST00000360428_ATG10_chr5_81354313_ENST00000513634_length(amino acids)=593AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKDIWEG
VHECYKMRLLQGPWDTITQQEHPILGQPFFVLHPCKTNEFMTPVLKNSQKINK

--------------------------------------------------------------
>24184_24184_6_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000282185_length(transcript)=4049nt_BP=1418nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGTTCTGATGGCTACATGT
GCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGTCTTCCCATGGAGGAGG
CTTTCGAGCTACCCTTGGATGATTGTGAAGTGATTGAAACTGCAGCAGCGTCCGAAGTGATTAAATATGAGTATCATGTCTTATATTCCT
GTAGCTACCAAGTGCCTGTACTTTACTTTAGGGCAAGCTTTTTAGATGGGAGACCTTTAACTCTGAAGGACATATGGGAAGGAGTTCATG
AGTGCTATAAGATGCGACTGCTACAGGGACCATGGGACACTATTACGCAACAGGAACATCCAATACTTGGGCAACCCTTTTTTGTACTTC
ATCCCTGCAAGACGAATGAATTCATGACTCCTGTATTAAAGAATTCTCAGAAAATCAATAAGAATGTCAACTATATCACATCATGGCTGA
GCATTGTAGGGCCAGTTGTTGGGCTGAATCTACCTCTGAGTTATGCCAAAGCAACGTCTCAGGATGAACGAAATGTCCCTTAACAAGATT
CTTCTATTGAGTTTAGGAATTGCGGCACGAAGAATGCCAAGAGTTTACCTGGCCAGCCCTGGCTTTAATAGGACTGATACCATGGAATAT
TTCATCTCACCAAGATGTGACATGGATTATTTTTCCCTTGGACACAAATGTCTACAGCAACTGGTGTTTGATAGGCTGAATGTTTAGAAG
AAACACTTCAAAGGGATACATCATGGCCAGGCATGGTGGCTCACACCTGTAATCCAAGCACTTTGGGAGGCCAAGGTGGGAGCATCACTT
GATCCTGGGAGTTCGAGACCAGCCTGGGCAACATGGTGAAACCCTGTCGGTACAAAAAAATACAAAAATTTGCCTGTTTATGGTGGTGTG
TTCCTGTAGTCCCAGCTCCCCAGGAGGCTGAGGTGGGAGGTTGGCTTTAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGACTGTGCCAC
TGCAGTCCAGCCTGGGTGACAGAGCCAGACACTGTCTCGGGGAAAAAAAAAAAAAAAAAAAGACACATCACTATAAATAGCAAAAAAACA
AATCTAACTTATTAATACTAGGAATACCAACATTATTAGGGCACTTGCAGGTTATTCTTTTCTAGGCCAAGTACTTCACTTCCATTTGTC
TGACATGGAGATTGAGGGAGAAATGTATTTGTGTGTTCATTTTAATGTAAGATATATAAAAATTAAATTACTGGATTTACCTGTCCCTGA
AACTGGTGTTATAAACATGACCTATCTTAAGTGATTTTCCCACAATCAAACTCAGGAACAATAGATTATTTCTGTTTTACTCCAAAAGAG
AGAGAGAGAGTGAGTGTGAGTGTGTGTGTGTGTGTGTGTGTATGTGTGGGTGTTTGTGTAGATAGTTGTAAAACAAAGAAAAAACACAAT
ATTTTACTGTGAGATAATATGTTTTACCAGCAAAGTGTGGCATAGTAATTAGAAGTTTTCTAAAAAGCTATAGGAGATATTTAAACATTA
AAATTTCTTTTTGACCTATAGTAATAAAACAATGGTCATTTTACCCCTCTGCTTCTCAACCCCACAGCTGCTCTGCTGTACTCTTTGAGG
GCTCTTGAGCGAGTCTTCATGTCCCTGAGACTTATTTTCCTCATCTTTAATTTGAAACTAACAAGCTACCTCATAGGGTTGCTGTGAGAA
CCACATGAGATCATTAATGCATGATAAGATATTGTAAAGTATTATACGAATATTCATTAAATGCTCACCTTTCTTGTATATAATTGGTAT
TCACTAAGGCTGTAAATAAGTTTCATAGCCAGTTAAGTATTAAGATAAACCTAACCTGGAACAATTTTTTTTTTGGTTGCTTGTTTTGTT
TTTTGCTTTCATTTGCTAGGAGCTGAAACGAAGATTAAAATGTCATTGGCTTTTTAGAGAGTCTAGATTAGTGTGTCTTTGAATGAGGGA
TATACTTAAAATCACCTGAGGATCGTTTACAGCTACAGATGCTGGGGCCACCTGACACAGTCTCTCTGGGGGTGATTCTGCTCTGGAGAA
CCTCTGGTCTGGATATACCTTTATTGTGACATTGATTTGTATTGTTTTGCTCTACTGACAGGCCTTTTCCAATCCATACAAGCTGAACTT
GCTTCCTAATGTTTGTCTAGGCCTTACATGGATAGTAAGGAAGCTTAGGAGACATGTACACAAGGCAGCCCACTTGTAGGAAACTGCTTC
AGGTGAGGACATCATTCACCAGTGGATCACCGAGCACCGTGACAGCACCCTCAGTCCACGTCTGCAGATTAAGAGCTGAACTCTCACAGA
GAAAGTGGAAGTAGAGAAAGGGTTAATTCAAACTGCTAGAAAAGCTAAAAGTAAATTTTAAAATGCTGAGCTGCCCATATTCATGCTAGG
ATGAGAGCCGGCTTAAATGCTTGCTGGGCATTTTGGTATTTACCACTTAGCATGTTTTCAACTTCTGTGAGGGATTTTCCCCCCAATCTC
CCTAATGTAAACACAGATTTCTCAGCAAGTCATTTCTCAAGCCATGTCATTTCTAGTGTAAAATAAATTATAATAATGTGTCATCTGAA

>24184_24184_6_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000282185_length(amino acids)=629AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKDIWEG
VHECYKMRLLQGPWDTITQQEHPILGQPFFVLHPCKTNEFMTPVLKNSQKINKNVNYITSWLSIVGPVVGLNLPLSYAKATSQDERNVP

--------------------------------------------------------------
>24184_24184_7_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000355178_length(transcript)=2454nt_BP=1418nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGTTCTGATGGCTACATGT
GCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGTCTTCCCATGGAGGTGA
AGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTTGCGTGATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTCAAGCAGTTCTCCTGCC
TCAGCCTTCCGAGTAACTGGGACTACAGGGGTTCACCACTACACCTGGCTAATTTTTTGTATTTTTAGTAGAGATAAGGTTTCACCATGT
TGGTCAGGCTGGTCTTGAACTCCTGACATCAAGTAATCCATCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAGGCATGAGCCACTGTGC
CTGGCCCTGAGCTTAAAATAAAAGTTAAATTAAAAAAAAAATAATGTTGATGTTTTCATTTTTGCAATCAATAGCTTAGTTAGACTCAAA
TTGCAAACTGTCATTGCCTGTAGTAGGCAGTGGCATAGAACTCAATTCAGCTCTTTTAACCTGAGTTTTAAGCTGCTTTCAGATTGCCCC
ACACATACATGGTTCAGGAGTCAGCCAGAGACTTGGGCTGAGTTTAAACATAGAATCTGGGGTTGTCCTCTTCTGGCTGTCTTCTTTCTT
GGGCATCTGCATCATTCTCTAGCACCTATGGTTTTTCCAGGCTCTTTCCCCCAGTTTCCTCCAGTCAGAAAGATGGCAAGAGTTTTTGCT
GCCTGCCCTCCCCCAGTCCTTGTGCCAACACCACCACCATTGCAGCTGCCTCCAGGGAAAAACTGCAAAAACCAAATCACTTGCTCCAGG
TGTTGACTCCTCTTCAAAATCTATTTTTGTTAAATCTCCAAAGCCTCAAATAGGTTTTCTTCCTAGAATTTATATCTGTTATTTGTAGCA
GGATTGGTCTGTAAGGCACTCAGTCTTCTACATCATGGGTCAGCAGATTACAGCCCTTGGGTTAAATCCAGCCACCTGCTTGTTTTATTA
ATAAAGTTTTGTTGGAACTAAACC

>24184_24184_7_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000355178_length(amino acids)=534AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEVKSCSVTQAGVQLRDLSSLQPPPSGFKQFSCLSLPSNWDYRGSPLHLANFLYF

--------------------------------------------------------------
>24184_24184_8_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000458350_length(transcript)=2702nt_BP=1418nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGTTCTGATGGCTACATGT
GCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGTCTTCCCATGGAGGAGG
CTTTCGAGCTACCCTTGGATGATTGTGAAGTGATTGAAACTGCAGCAGCGTCCGAAGTGATTAAATATGAGTATCATGTCTTATATTCCT
GTAGCTACCAAGTGCCTGTACTTTACTTTAGGGCAAGCTTTTTAGATGGGAGACCTTTAACTCTGAAGGACATATGGGAAGGAGTTCATG
AGTGCTATAAGATGCGACTGCTACAGGGACCATGGGACACTATTACGCAACAGGAACATCCAATACTTGGGCAACCCTTTTTTGTACTTC
ATCCCTGCAAGACGAATGAATTCATGACTCCTGTATTAAAGAATTCTCAGAAAATCAATAAGAATGTCAACTATATCACATCATGGCTGA
GCATTGTAGGGCCAGTTGTTGGGCTGAATCTACCTCTGAGTTATGCCAAAGCAACGTCTCAGGATGAACGAAATGTCCCTTAACAAGATT
CTTCTATTGAGTTTAGGAATTGCGGCACGAAGAATGCCAAGAGTTTACCTGGCCAGCCCTGGCTTTAATAGGACTGATACCATGGAATAT
TTCATCTCACCAAGATGTGACATGGATTATTTTTCCCTTGGACACAAATGTCTACAGCAACTGGTGTTTGATAGGCTGAATGTTTAGAAG
AAACACTTCAAAGGGATACATCATGGCCAGGCATGGTGGCTCACACCTGTAATCCAAGCACTTTGGGAGGCCAAGGTGGGAGCATCACTT
GATCCTGGGAGTTCGAGACCAGCCTGGGCAACATGGTGAAACCCTGTCGGTACAAAAAAATACAAAAATTTGCCTGTTTATGGTGGTGTG
TTCCTGTAGTCCCAGCTCCCCAGGAGGCTGAGGTGGGAGGTTGGCTTTAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGACTGTGCCAC
TGCAGTCCAGCCTGGGTGACAGAGCCAGACACTGTCTCGGGGAAAAAAAAAAAAAAAAAAAGACACATCACTATAAATAGCAAAAAAACA
AATCTAACTTATTAATACTAGGAATACCAACATTATTAGGGCACTTGCAGGTTATTCTTTTCTAGGCCAAGTACTTCACTTCCATTTGTC
TGACATGGAGATTGAGGGAGAAATGTATTTGTGTGTTCATTTTAATGTAAGATATATAAAAATTAAATTACTGGATTTACCTGTCCCTGA
AA

>24184_24184_8_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000458350_length(amino acids)=629AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKDIWEG
VHECYKMRLLQGPWDTITQQEHPILGQPFFVLHPCKTNEFMTPVLKNSQKINKNVNYITSWLSIVGPVVGLNLPLSYAKATSQDERNVP

--------------------------------------------------------------
>24184_24184_9_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000513443_length(transcript)=1841nt_BP=1418nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGTTCTGATGGCTACATGT
GCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGTCTTCCCATGGAGGTGA
AGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTTGCGTGATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTCAAGCAGTTCTCCTGCC
TCAGCCTTCCGAGTAACTGGGACTACAGGGGTTCACCACTACACCTGGCTAATTTTTTGTATTTTTAGTAGAGATAAGGTTTCACCATGT
TGGTCAGGCTGGTCTTGAACTCCTGACATCAAGTAATCCATCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAGGCATGAGCCACTGTGC
CTGGCCCTGAGCTTAAAATAAAAGTTAAATTAAAAAAAAAA

>24184_24184_9_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000513443_length(amino acids)=534AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEVKSCSVTQAGVQLRDLSSLQPPPSGFKQFSCLSLPSNWDYRGSPLHLANFLYF

--------------------------------------------------------------
>24184_24184_10_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000513634_length(transcript)=1915nt_BP=1418nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGGACTGTTCTGATGGCTACATGT
GCAAAATACACTTTCAAATTAAGAATGGGTCTGTGATGTCACATCTAGGAGCATCTACCCATGGACAGACATGTCTTCCCATGGAGGAGG
CTTTCGAGCTACCCTTGGATGATTGTGAAGTGATTGAAACTGCAGCAGCGTCCGAAGTGATTAAATATGAGTATCATGTCTTATATTCCT
GTAGCTACCAAGTGCCTGTACTTTACTTTAGGGCAAGCTTTTTAGATGGGAGACCTTTAACTCTGAAGGACATATGGGAAGGAGTTCATG
AGTGCTATAAGATGCGACTGCTACAGGGACCATGGGACACTATTACGCAACAGGAACATCCAATACTTGGGCAACCCTTTTTTGTACTTC
ATCCCTGCAAGACGAATGAATTCATGACTCCTGTATTAAAGAATTCTCAGAAAATCAATAAGTAAGAAACACCATCAAGATACATTGGCT
TCTACTCTGATTTTAAAAGTGTAAA

>24184_24184_10_DSC3-ATG10_DSC3_chr18_28598036_ENST00000434452_ATG10_chr5_81354313_ENST00000513634_length(amino acids)=593AA_BP=445
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKDCSDG
YMCKIHFQIKNGSVMSHLGASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLYFRASFLDGRPLTLKDIWEG
VHECYKMRLLQGPWDTITQQEHPILGQPFFVLHPCKTNEFMTPVLKNSQKINK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DSC3-ATG10

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DSC3-ATG10

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DSC3-ATG10

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	DSC3	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	DSC3	C0678222	Breast Carcinoma	1	CTD_human
Hgene	DSC3	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	DSC3	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	DSC3	C2751292	Hypotrichosis And Recurrent Skin Vesicles	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	DSC3	C4704874	Mammary Carcinoma, Human	1	CTD_human
Tgene		C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene		C0678222	Breast Carcinoma	1	CTD_human
Tgene		C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene		C1458155	Mammary Neoplasms	1	CTD_human
Tgene		C4704874	Mammary Carcinoma, Human	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:DSC3-ATG10 (FusionGDB2 ID:HG1825TG83734)

Fusion Gene Summary for DSC3-ATG10

Fusion Gene ORF analysis for DSC3-ATG10

Fusion Genomic Features for DSC3-ATG10

Fusion Protein Features for DSC3-ATG10

Fusion Gene Sequence for DSC3-ATG10

Fusion Gene PPI Analysis for DSC3-ATG10

Related Drugs for DSC3-ATG10

Related Diseases for DSC3-ATG10

Fusion Gene Studies
in Kim Lab