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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EDNRB-TBC1D4 (FusionGDB2 ID:HG1910TG9882)

Fusion Gene Summary for EDNRB-TBC1D4

check button Fusion gene summary
Fusion gene informationFusion gene name: EDNRB-TBC1D4
Fusion gene ID: hg1910tg9882
HgeneTgene
Gene symbol

EDNRB

TBC1D4

Gene ID

1910

9882

Gene nameendothelin receptor type BTBC1 domain family member 4
SynonymsABCDS|ET-B|ET-BR|ETB|ETB1|ETBR|ETRB|HSCR|HSCR2|WS4AAS160|NIDDM5
Cytomap('EDNRB')('TBC1D4')

13q22.3

13q22.2

Type of geneprotein-codingprotein-coding
Descriptionendothelin receptor type BHirschsprung disease 2endothelin receptor non-selective typeendothelin receptor subtype B1TBC1 domain family member 4TBC (Tre-2, BUB2, CDC16) domain-containing proteinakt substrate of 160 kDa
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000334286, ENST00000377211, 
ENST00000446573, ENST00000475537, 
ENST00000334286, ENST00000377211, 
ENST00000446573, ENST00000475537, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 3 X 4=48
# samples 44
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EDNRB [Title/Abstract] AND TBC1D4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEDNRB(78473994)-TBC1D4(75936743), # samples:1
Anticipated loss of major functional domain due to fusion event.EDNRB-TBC1D4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EDNRB-TBC1D4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EDNRB-TBC1D4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EDNRB-TBC1D4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEDNRB

GO:0086100

endothelin receptor signaling pathway

1713452


check buttonFusion gene breakpoints across EDNRB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TBC1D4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-S9-A7IZEDNRBchr13

78473994

-TBC1D4chr13

75936743

-


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Fusion Gene ORF analysis for EDNRB-TBC1D4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000334286ENST00000377625EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
5CDS-5UTRENST00000334286ENST00000425511EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
5CDS-5UTRENST00000377211ENST00000377625EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
5CDS-5UTRENST00000377211ENST00000425511EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
5CDS-5UTRENST00000446573ENST00000377625EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
5CDS-5UTRENST00000446573ENST00000425511EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
5CDS-intronENST00000334286ENST00000478591EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
5CDS-intronENST00000377211ENST00000478591EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
5CDS-intronENST00000446573ENST00000478591EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
In-frameENST00000334286ENST00000377636EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
In-frameENST00000334286ENST00000431480EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
In-frameENST00000377211ENST00000377636EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
In-frameENST00000377211ENST00000431480EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
In-frameENST00000446573ENST00000377636EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
In-frameENST00000446573ENST00000431480EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
intron-3CDSENST00000475537ENST00000377636EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
intron-3CDSENST00000475537ENST00000431480EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
intron-5UTRENST00000475537ENST00000377625EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
intron-5UTRENST00000475537ENST00000425511EDNRBchr13

78473994

-TBC1D4chr13

75936743

-
intron-intronENST00000475537ENST00000478591EDNRBchr13

78473994

-TBC1D4chr13

75936743

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000446573EDNRBchr1378473994-ENST00000377636TBC1D4chr1375936743-6971145221048501546
ENST00000446573EDNRBchr1378473994-ENST00000431480TBC1D4chr1375936743-6946145221048261538
ENST00000377211EDNRBchr1378473994-ENST00000377636TBC1D4chr1375936743-7136161715350151620
ENST00000377211EDNRBchr1378473994-ENST00000431480TBC1D4chr1375936743-7111161715349911612
ENST00000334286EDNRBchr1378473994-ENST00000377636TBC1D4chr1375936743-6950143118948291546
ENST00000334286EDNRBchr1378473994-ENST00000431480TBC1D4chr1375936743-6925143118948051538

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000446573ENST00000377636EDNRBchr1378473994-TBC1D4chr1375936743-0.0004291960.9995708
ENST00000446573ENST00000431480EDNRBchr1378473994-TBC1D4chr1375936743-0.0003900040.99961
ENST00000377211ENST00000377636EDNRBchr1378473994-TBC1D4chr1375936743-0.0004620770.99953794
ENST00000377211ENST00000431480EDNRBchr1378473994-TBC1D4chr1375936743-0.0004167170.9995833
ENST00000334286ENST00000377636EDNRBchr1378473994-TBC1D4chr1375936743-0.0004194350.99958056
ENST00000334286ENST00000431480EDNRBchr1378473994-TBC1D4chr1375936743-0.0003810960.9996189

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Fusion Genomic Features for EDNRB-TBC1D4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for EDNRB-TBC1D4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:78473994/chr13:75936743)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67127_137398443.0Topological domainCytoplasmic
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67164_175398443.0Topological domainExtracellular
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67198_218398443.0Topological domainCytoplasmic
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67244_271398443.0Topological domainExtracellular
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-6727_101398443.0Topological domainExtracellular
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67297_324398443.0Topological domainCytoplasmic
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67351_362398443.0Topological domainExtracellular
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78127_137488533.0Topological domainCytoplasmic
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78164_175488533.0Topological domainExtracellular
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78198_218488533.0Topological domainCytoplasmic
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78244_271488533.0Topological domainExtracellular
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-7827_101488533.0Topological domainExtracellular
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78297_324488533.0Topological domainCytoplasmic
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78351_362488533.0Topological domainExtracellular
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78390_442488533.0Topological domainCytoplasmic
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67127_137398437.0Topological domainCytoplasmic
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67164_175398437.0Topological domainExtracellular
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67198_218398437.0Topological domainCytoplasmic
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67244_271398437.0Topological domainExtracellular
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-6727_101398437.0Topological domainExtracellular
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67297_324398437.0Topological domainCytoplasmic
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67351_362398437.0Topological domainExtracellular
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67102_126398443.0TransmembraneHelical%3B Name%3D1
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67138_163398443.0TransmembraneHelical%3B Name%3D2
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67176_197398443.0TransmembraneHelical%3B Name%3D3
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67219_243398443.0TransmembraneHelical%3B Name%3D4
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67272_296398443.0TransmembraneHelical%3B Name%3D5
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67325_350398443.0TransmembraneHelical%3B Name%3D6
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67363_389398443.0TransmembraneHelical%3B Name%3D7
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78102_126488533.0TransmembraneHelical%3B Name%3D1
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78138_163488533.0TransmembraneHelical%3B Name%3D2
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78176_197488533.0TransmembraneHelical%3B Name%3D3
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78219_243488533.0TransmembraneHelical%3B Name%3D4
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78272_296488533.0TransmembraneHelical%3B Name%3D5
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78325_350488533.0TransmembraneHelical%3B Name%3D6
HgeneEDNRBchr13:78473994chr13:75936743ENST00000377211-78363_389488533.0TransmembraneHelical%3B Name%3D7
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67102_126398437.0TransmembraneHelical%3B Name%3D1
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67138_163398437.0TransmembraneHelical%3B Name%3D2
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67176_197398437.0TransmembraneHelical%3B Name%3D3
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67219_243398437.0TransmembraneHelical%3B Name%3D4
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67272_296398437.0TransmembraneHelical%3B Name%3D5
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67325_350398437.0TransmembraneHelical%3B Name%3D6
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67363_389398437.0TransmembraneHelical%3B Name%3D7
TgeneTBC1D4chr13:78473994chr13:75936743ENST00000377625019672_7591661236.0Compositional biasNote=Ser-rich
TgeneTBC1D4chr13:78473994chr13:75936743ENST00000377636021672_7591661299.0Compositional biasNote=Ser-rich
TgeneTBC1D4chr13:78473994chr13:75936743ENST00000425511020672_7590463.0Compositional biasNote=Ser-rich
TgeneTBC1D4chr13:78473994chr13:75936743ENST00000431480020672_7591661291.0Compositional biasNote=Ser-rich
TgeneTBC1D4chr13:78473994chr13:75936743ENST00000377625019312_4681661236.0DomainPID 2
TgeneTBC1D4chr13:78473994chr13:75936743ENST00000377625019918_11121661236.0DomainRab-GAP TBC
TgeneTBC1D4chr13:78473994chr13:75936743ENST00000377636021312_4681661299.0DomainPID 2
TgeneTBC1D4chr13:78473994chr13:75936743ENST00000377636021918_11121661299.0DomainRab-GAP TBC
TgeneTBC1D4chr13:78473994chr13:75936743ENST00000425511020312_4680463.0DomainPID 2
TgeneTBC1D4chr13:78473994chr13:75936743ENST0000042551102053_2090463.0DomainPID 1
TgeneTBC1D4chr13:78473994chr13:75936743ENST00000425511020918_11120463.0DomainRab-GAP TBC
TgeneTBC1D4chr13:78473994chr13:75936743ENST00000431480020312_4681661291.0DomainPID 2
TgeneTBC1D4chr13:78473994chr13:75936743ENST00000431480020918_11121661291.0DomainRab-GAP TBC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEDNRBchr13:78473994chr13:75936743ENST00000334286-67390_442398443.0Topological domainCytoplasmic
HgeneEDNRBchr13:78473994chr13:75936743ENST00000446573-67390_442398437.0Topological domainCytoplasmic
TgeneTBC1D4chr13:78473994chr13:75936743ENST0000037762501953_2091661236.0DomainPID 1
TgeneTBC1D4chr13:78473994chr13:75936743ENST0000037763602153_2091661299.0DomainPID 1
TgeneTBC1D4chr13:78473994chr13:75936743ENST0000043148002053_2091661291.0DomainPID 1


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Fusion Gene Sequence for EDNRB-TBC1D4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24993_24993_1_EDNRB-TBC1D4_EDNRB_chr13_78473994_ENST00000334286_TBC1D4_chr13_75936743_ENST00000377636_length(transcript)=6950nt_BP=1431nt
ATCAGGAAGGAGTTTCGACCCGCGCTGGCGAGTCATGAGCGCCAAGTTTCCCACTGGCGCGCAAACTTGAGTTACTTTTGAGCGTGGATA
CTGGCGAAGAGGCTGCGGGCGGTATTAGCGTTTGCAGCGACTTGGCTCGGGCAGCTGACCCAAGTGTCCTGTCTTCCTTCCTCTGCTTGT
CTCTAGGCTCTGAAACTGCGGAGCGGCCACCGGACGCCTTCTGGAGCAGGTAGCAGCATGCAGCCGCCTCCAAGTCTGTGCGGACGCGCC
CTGGTTGCGCTGGTTCTTGCCTGCGGCCTGTCGCGGATCTGGGGAGAGGAGAGAGGCTTCCCGCCTGACAGGGCCACTCCGCTTTTGCAA
ACCGCAGAGATAATGACGCCACCCACTAAGACCTTATGGCCCAAGGGTTCCAACGCCAGTCTGGCGCGGTCGTTGGCACCTGCGGAGGTG
CCTAAAGGAGACAGGACGGCAGGATCTCCGCCACGCACCATCTCCCCTCCCCCGTGCCAAGGACCCATCGAGATCAAGGAGACTTTCAAA
TACATCAACACGGTTGTGTCCTGCCTTGTGTTCGTGCTGGGGATCATCGGGAACTCCACACTTCTGAGAATTATCTACAAGAACAAGTGC
ATGCGAAACGGTCCCAATATCTTGATCGCCAGCTTGGCTCTGGGAGACCTGCTGCACATCGTCATTGACATCCCTATCAATGTCTACAAG
CTGCTGGCAGAGGACTGGCCATTTGGAGCTGAGATGTGTAAGCTGGTGCCTTTCATACAGAAAGCCTCTGTGGGAATCACTGTGCTGAGT
CTATGTGCTCTGAGTATTGACAGATATCGAGCTGTTGCTTCTTGGAGTAGAATTAAAGGAATTGGGGTTCCAAAATGGACAGCAGTAGAA
ATTGTTTTGATTTGGGTGGTCTCTGTGGTTCTGGCTGTCCCTGAAGCCATAGGTTTTGATATAATTACGATGGACTACAAAGGAAGTTAT
CTGCGAATCTGCTTGCTTCATCCCGTTCAGAAGACAGCTTTCATGCAGTTTTACAAGACAGCAAAAGATTGGTGGCTATTCAGTTTCTAT
TTCTGCTTGCCATTGGCCATCACTGCATTTTTTTATACACTAATGACCTGTGAAATGTTGAGAAAGAAAAGTGGCATGCAGATTGCTTTA
AATGATCACCTAAAGCAGAGACGGGAAGTGGCCAAAACCGTCTTTTGCCTGGTCCTTGTCTTTGCCCTCTGCTGGCTTCCCCTTCACCTC
AGCAGGATTCTGAAGCTCACTCTTTATAATCAGAATGATCCCAATAGATGTGAACTTTTGAGCTTTCTGTTGGTATTGGACTATATTGGT
ATCAACATGGCTTCACTGAATTCCTGCATTAACCCAATTGCTCTGTATTTGGTGAGCAAAAGATTCAAAAACTGCTTTAAGGTTCCTGAT
GTTATTAGCAGCATAAGGCAATTATCTAAAGCGGCCATGAAAGAGGATGCCAAACCCAGCAAAGATAATGAGGACGCCTTTTACAACTCT
CAGAAGTTCGAAGTCCTGTACTGTGGAAAGGTGACCGTGACCCACAAGAAGGCCCCCTCAAGCCTCATCGATGACTGCATGGAGAAGTTC
AGCCTGCACGAACAGCAGCGCCTGAAGATCCAAGGGGAGCAGCGCGGTCCGGACCCAGGAGAGGACCTGGCTGACTTGGAGGTGGTGGTG
CCCGGGTCCCCCGGAGACTGCCTGCCGGAGGAGGCTGACGGCACCGACACCCACCTTGGCTTACCTGCCGGGGCCAGCCAGCCTGCCCTG
ACCAGCTCTCGGGTCTGCTTCCCTGAGCGGATTTTGGAAGATTCTGGCTTTGATGAGCAGCAGGAGTTTCGGTCTCGGTGCAGCAGTGTC
ACCGGCGTGCAACGGAGAGTTCACGAGGGCAGCCAGAAATCCCAGCCGCGACGGAGACACGCGAGCGCACCCAGTCACGTCCAGCCCTCG
GACTCGGAGAAGAACAGGACCATGCTCTTCCAGGTTGGGCGATTTGAGATTAACCTTATCAGTCCAGACACTAAATCAGTTGTGCTAGAA
AAGAATTTTAAAGATATCTCCTCTTGTTCTCAGGGTATAAAGCATGTGGATCACTTTGGCTTTATCTGCCGGGAGTCTCCAGAGCCTGGA
CTTAGCCAGTATATTTGTTATGTATTCCAGTGTGCCAGCGAATCTCTGGTTGATGAGGTAATGCTGACTCTGAAACAGGCCTTCAGTACG
GCGGCTGCCCTGCAGAGTGCCAAGACGCAGATTAAACTGTGTGAGGCCTGCCCGATGCACTCTTTGCATAAGCTCTGTGAAAGGATTGAA
GGTCTCTACCCACCAAGAGCCAAGCTGGTGATACAGAGGCATCTCTCATCACTGACAGATAATGAGCAAGCTGACATCTTTGAAAGAGTT
CAGAAAATGAAGCCAGTCAGTGACCAGGAAGAAAATGAACTTGTGATTTTACACCTGAGGCAGCTGTGTGAAGCCAAGCAGAAGACACAC
GTGCACATCGGGGAAGGCCCTTCTACTATTTCAAATAGTACAATCCCAGAAAATGCAACAAGCAGTGGAAGGTTCAAACTTGACATTCTG
AAAAATAAAGCTAAGAGATCCTTAACTAGCTCCCTGGAAAATATCTTCTCAAGGGGAGCTAACAGAATGAGAGGTCGGCTTGGAAGTGTG
GACAGTTTTGAACGGTCCAACAGTCTTGCTTCAGAGAAGGACTACTCACCAGGGGATTCTCCACCAGGGACACCGCCAGCGTCCCCACCG
TCCTCAGCTTGGCAAACGTTTCCCGAAGAGGATTCCGACTCCCCGCAGTTTCGAAGACGGGCACACACGTTCAGCCACCCACCTTCAAGC
ACAAAGAGAAAGCTGAATTTGCAGGATGGGAGGGCTCAGGGTGTGCGTTCCCCTCTGCTGAGGCAGAGCTCCAGTGAACAGTGCAGCAAT
CTTTCGTCAGTTCGACGCATGTACAAGGAGAGTAATTCTTCCTCCAGTCTTCCAAGTCTTCACACTTCCTTCTCTGCCCCTTCCTTCACT
GCCCCCTCTTTCCTGAAAAGCTTTTACCAGAATTCAGGTAGACTGTCCCCACAGTATGAAAATGAAATCAGACAAGACACTGCTTCAGAA
TCAAGTGATGGAGAAGGGAGAAAAAGGACCTCATCTACCTGCAGCAATGAGTCCCTAAGTGTGGGAGGAACCTCTGTCACTCCTCGCCGG
ATCTCCTGGCGGCAGCGCATTTTCCTCAGGGTTGCTTCTCCCATGAACAAATCTCCCTCAGCAATGCAACAGCAAGATGGATTGGACAGG
AACGAGCTGCTGCCACTGTCCCCCCTCTCTCCAACCATGGAGGAGGAACCGCTGGTTGTATTCCTGTCTGGGGAGGATGACCCAGAAAAG
ATTGAAGAAAGAAAGAAATCAAAAGAACTGAGGAGCTTGTGGAGAAAAGCTATACACCAACAAATCTTGTTACTTCGAATGGAAAAAGAA
AACCAGAAACTTGAAGCAAGCAGAGATGAACTCCAGTCCAGAAAAGTTAAATTAGACTATGAAGAAGTTGGTGCATGTCAGAAAGAGGTC
TTAATAACTTGGGATAAGAAGTTGTTAAACTGCAGAGCTAAAATCAGATGTGATATGGAAGATATTCATACTCTTCTTAAAGAAGGAGTT
CCCAAAAGTCGACGAGGAGAAATTTGGCAGTTTCTGGCTTTACAGTACCGACTCAGACACAGATTGCCTAATAAACAACAGCCTCCTGAC
ATATCCTATAAGGAACTTTTGAAGCAGCTCACTGCTCAGCAGCATGCGATTCTCGTGGATTTAGGAAGGACGTTTCCTACTCACCCTTAC
TTTTCAGTACAGCTTGGGCCAGGACAGCTGTCACTGTTTAACCTCCTGAAAGCCTATTCTTTGCTGGACAAAGAAGTGGGATACTGTCAG
GGGATCAGCTTTGTGGCTGGAGTCCTGCTTCTGCACATGAGTGAAGAGCAAGCCTTTGAAATGCTGAAATTCCTCATGTATGACCTCGGC
TTCCGCAAGCAGTACAGACCTGACATGATGTCGCTGCAGATTCAAATGTACCAGCTGTCCAGGCTCCTTCATGACTATCACAGAGATCTC
TACAATCACCTTGAAGAAAATGAAATCAGCCCCAGTCTTTATGCTGCCCCCTGGTTCCTCACATTGTTTGCCTCTCAGTTTTCATTAGGA
TTTGTAGCCAGAGTTTTTGATATTATTTTTCTTCAGGGAACTGAAGTTATATTCAAGGTTGCACTCAGCCTACTGAGCAGCCAAGAGACA
CTTATAATGGAATGTGAGAGCTTTGAAAATATTGTTGAGTTTCTTAAAAACACGCTACCTGATATGAATACCTCTGAAATGGAAAAAATT
ATTACCCAGGTTTTTGAGATGGATATTTCTAAGCAGTTGCATGCCTATGAGGTGGAATATCATGTGCTACAGGATGAGCTTCAGGAATCT
TCATATTCCTGTGAGGATAGTGAAACTTTGGAGAAGCTGGAGAGGGCCAATAGCCAACTGAAAAGACAAAACATGGACCTCCTAGAAAAA
TTACAGGTAGCTCATACTAAAATCCAGGCCTTGGAATCAAACCTGGAAAATCTTTTGACGAGAGAGACCAAAATGAAGTCTTTAATCCGG
ACCCTGGAACAAGAAAAAATGGCTTATCAAAAGACAGTGGAGCAACTCCGGAAGCTGCTGCCCGCGGATGCTCTAGTCAATTGTGACCTG
TTGCTGAGAGACCTAAACTGCAACCCTAACAACAAAGCCAAGATAGGAAATAAGCCATAATTGAAGAGGCACGGCCTCAGCAGAAAGTGC
TCCTTAGAATACTACAGAGAGGAAGAGCCTGCATGTCGCTGGCCCAAGGCTGGACCCTGAAGCTGATGGAACCACCTAATACTGGTGCTG
AGCGCCTAGTCACAGCAGGTGGACCTCGTGCTCATCAGAGCATGCCAATCCTAAGCCATTGGACATATGTAGACTGGTTTTTGTTGTTGC
TATGTACATATAAATATATATATAAAATGAACATAGTTCATGCTTTCAGATAAAATGAGTAGATGTATATTTAGATTAATTTTTTTAGTC
AGAACTTCATGAAATCCACACCAAAGGAAAGGTAAACTGAAATTTCCCTTGGACATATGTGAAATCTTTTTGTCTTTATAGTGAAACAAA
GCCAGAGCATCTTTGTATATTGCAATATACTTGAAAAAAATGAATGTATTTTTTTCTCCAAAGAACAGCATGTTTCACTCAATGGTGAAA
AGGTGGAAACATTTATGTAACTTTATGTGTATCTGTCTTGATATCTACTGACATTGTCTATATGAGGAAAATGATTACTGGTCATGCTCC
TGTGAGTTTTTTGGGAAGGTAGGGTCATTTCTCCCTGCCTGCTTTGTGCCAACTAGCATGTTGCATCTACATGCATTATGAGTCTGGTTA
GGCATTACTTTAAACATACATAAAGAGACAGTAGGACATTGTGGCTGAGTCTACCCAGCTCAAGGTAAAGGAGAATGTTGCTAATTTTTT
AGCAAACTAGACCAGCATTATTACTCAAACTAAAAATATCACACCTGAAAAATTTAATTTAGGACCTAAAATGTCTAGATTAGCTTTCTG
CTTTTTTTATTTGAATAACTCATTCAGTTGTGAATGAATTCCTCTTTATTTGGTGCCACAGTCACCAAATGACAAGGATTTGCCACTTTC
CCACCAAATTGTGAGTGCTTGTAATTTAGGTCTCTCTACCTTAAATTCAGTATAAGGAAACGTAATTATGATTGATTTTTTCCAAAGATG
ACAAGCTGTGTTGAAATACATTTTTTCTTTTGACCAATTGACAGAATCTAATAAGCTTTAATAATCTTCCCCTTTTATGTGAAAAGTTTT
GAGAACTGTGAAATGTTTAGGAACAAACTGTTGAAATCCATTGGAAGGGAAAAAAGAAAGTGGTACCAGTGTTACCAGCTCAACTAAAAC
CTGCAATTCTGCATTTCAACTCTTCACTTCCTCAGCCTACAAATAGCTCATTAGATGACATTCACGCATGCTGGGTATAGGCAAGGAAAG
TAATTTTCAAAGTACATTTGCAGTTCTCTTTTTCAGAGATGATTCTATGATAGTGCCTCTGAAAGTTGATGCAGCATTTTTGCCTTTCCA
AAAAGTATTTATCCTCACTGCTTTTTGCAGTACTTGTATTTTCACAGATGGATTATCTGGGGTAATTTTCTTCAAAGGGAGTTTGTTATA
CACAGTGAAAATGTATTATAGAGTAGAATAGTAAAGCTCTAGGGGTTTCAGAAAGCTTTGATGAACAGATGACAAACATCTGAAACCCCC
TCCGCACTGTTACCCAGTGTGTATATAATGACTTGTTATAGCTCAGTGTGCCCTTGAATCCATACAGTTTCTTAAAAGACAATAAAATCT
TATTAATAAAGTTAATGTAACTTCTAAGTTCTAGAAAATGCTGATTCTGTCTGCCCCATTCAATTGGGGGCTACTAATTGATTTGTTGCT
TGGATTTCCTGAGAATTTCTCTATTTGTAGGAGGGGTTTTTTCTTTTTACGGTCTGTTGATGACAATTACTTTATGGGTGTGATGCACCG
ATGGTAGCCAAGGAATCTGTTGGGGAAGTTCGGAAAGAAACCTTTTCTTTCTTTTATTCAGTTTAAAGTAAACTTTATCCTGGATGTTTA
GAATCAACATTAAGAGTTATATTATGGTGTTCAGAGATTAAGCTGACTTGGATACAATATTTTCTTTTGAAAATGAATTTTCTTTTTCAT
TTGTGATTTTTAAAAAATGTTGCACCAGTTATGCTTCATGCATCGTTACATCTTCATCAGGTTAATGTAATGTCTAGTTCCTTTGCAATA

>24993_24993_1_EDNRB-TBC1D4_EDNRB_chr13_78473994_ENST00000334286_TBC1D4_chr13_75936743_ENST00000377636_length(amino acids)=1546AA_BP=1
MKLRSGHRTPSGAGSSMQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKG
DRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLA
EDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRI
CLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRI
LKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKF
EVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSS
RVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNF
KDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLY
PPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNK
AKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKR
KLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSD
GEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEE
RKKSKELRSLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKS
RRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGIS
FVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVA
RVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYS
CEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLR

--------------------------------------------------------------
>24993_24993_2_EDNRB-TBC1D4_EDNRB_chr13_78473994_ENST00000334286_TBC1D4_chr13_75936743_ENST00000431480_length(transcript)=6925nt_BP=1431nt
ATCAGGAAGGAGTTTCGACCCGCGCTGGCGAGTCATGAGCGCCAAGTTTCCCACTGGCGCGCAAACTTGAGTTACTTTTGAGCGTGGATA
CTGGCGAAGAGGCTGCGGGCGGTATTAGCGTTTGCAGCGACTTGGCTCGGGCAGCTGACCCAAGTGTCCTGTCTTCCTTCCTCTGCTTGT
CTCTAGGCTCTGAAACTGCGGAGCGGCCACCGGACGCCTTCTGGAGCAGGTAGCAGCATGCAGCCGCCTCCAAGTCTGTGCGGACGCGCC
CTGGTTGCGCTGGTTCTTGCCTGCGGCCTGTCGCGGATCTGGGGAGAGGAGAGAGGCTTCCCGCCTGACAGGGCCACTCCGCTTTTGCAA
ACCGCAGAGATAATGACGCCACCCACTAAGACCTTATGGCCCAAGGGTTCCAACGCCAGTCTGGCGCGGTCGTTGGCACCTGCGGAGGTG
CCTAAAGGAGACAGGACGGCAGGATCTCCGCCACGCACCATCTCCCCTCCCCCGTGCCAAGGACCCATCGAGATCAAGGAGACTTTCAAA
TACATCAACACGGTTGTGTCCTGCCTTGTGTTCGTGCTGGGGATCATCGGGAACTCCACACTTCTGAGAATTATCTACAAGAACAAGTGC
ATGCGAAACGGTCCCAATATCTTGATCGCCAGCTTGGCTCTGGGAGACCTGCTGCACATCGTCATTGACATCCCTATCAATGTCTACAAG
CTGCTGGCAGAGGACTGGCCATTTGGAGCTGAGATGTGTAAGCTGGTGCCTTTCATACAGAAAGCCTCTGTGGGAATCACTGTGCTGAGT
CTATGTGCTCTGAGTATTGACAGATATCGAGCTGTTGCTTCTTGGAGTAGAATTAAAGGAATTGGGGTTCCAAAATGGACAGCAGTAGAA
ATTGTTTTGATTTGGGTGGTCTCTGTGGTTCTGGCTGTCCCTGAAGCCATAGGTTTTGATATAATTACGATGGACTACAAAGGAAGTTAT
CTGCGAATCTGCTTGCTTCATCCCGTTCAGAAGACAGCTTTCATGCAGTTTTACAAGACAGCAAAAGATTGGTGGCTATTCAGTTTCTAT
TTCTGCTTGCCATTGGCCATCACTGCATTTTTTTATACACTAATGACCTGTGAAATGTTGAGAAAGAAAAGTGGCATGCAGATTGCTTTA
AATGATCACCTAAAGCAGAGACGGGAAGTGGCCAAAACCGTCTTTTGCCTGGTCCTTGTCTTTGCCCTCTGCTGGCTTCCCCTTCACCTC
AGCAGGATTCTGAAGCTCACTCTTTATAATCAGAATGATCCCAATAGATGTGAACTTTTGAGCTTTCTGTTGGTATTGGACTATATTGGT
ATCAACATGGCTTCACTGAATTCCTGCATTAACCCAATTGCTCTGTATTTGGTGAGCAAAAGATTCAAAAACTGCTTTAAGGTTCCTGAT
GTTATTAGCAGCATAAGGCAATTATCTAAAGCGGCCATGAAAGAGGATGCCAAACCCAGCAAAGATAATGAGGACGCCTTTTACAACTCT
CAGAAGTTCGAAGTCCTGTACTGTGGAAAGGTGACCGTGACCCACAAGAAGGCCCCCTCAAGCCTCATCGATGACTGCATGGAGAAGTTC
AGCCTGCACGAACAGCAGCGCCTGAAGATCCAAGGGGAGCAGCGCGGTCCGGACCCAGGAGAGGACCTGGCTGACTTGGAGGTGGTGGTG
CCCGGGTCCCCCGGAGACTGCCTGCCGGAGGAGGCTGACGGCACCGACACCCACCTTGGCTTACCTGCCGGGGCCAGCCAGCCTGCCCTG
ACCAGCTCTCGGGTCTGCTTCCCTGAGCGGATTTTGGAAGATTCTGGCTTTGATGAGCAGCAGGAGTTTCGGTCTCGGTGCAGCAGTGTC
ACCGGCGTGCAACGGAGAGTTCACGAGGGCAGCCAGAAATCCCAGCCGCGACGGAGACACGCGAGCGCACCCAGTCACGTCCAGCCCTCG
GACTCGGAGAAGAACAGGACCATGCTCTTCCAGGTTGGGCGATTTGAGATTAACCTTATCAGTCCAGACACTAAATCAGTTGTGCTAGAA
AAGAATTTTAAAGATATCTCCTCTTGTTCTCAGGGTATAAAGCATGTGGATCACTTTGGCTTTATCTGCCGGGAGTCTCCAGAGCCTGGA
CTTAGCCAGTATATTTGTTATGTATTCCAGTGTGCCAGCGAATCTCTGGTTGATGAGGTAATGCTGACTCTGAAACAGGCCTTCAGTACG
GCGGCTGCCCTGCAGAGTGCCAAGACGCAGATTAAACTGTGTGAGGCCTGCCCGATGCACTCTTTGCATAAGCTCTGTGAAAGGATTGAA
GGTCTCTACCCACCAAGAGCCAAGCTGGTGATACAGAGGCATCTCTCATCACTGACAGATAATGAGCAAGCTGACATCTTTGAAAGAGTT
CAGAAAATGAAGCCAGTCAGTGACCAGGAAGAAAATGAACTTGTGATTTTACACCTGAGGCAGCTGTGTGAAGCCAAGCAGAAGACACAC
GTGCACATCGGGGAAGGCCCTTCTACTATTTCAAATAGTACAATCCCAGAAAATGCAACAAGCAGTGGAAGGTTCAAACTTGACATTCTG
AAAAATAAAGCTAAGAGATCCTTAACTAGCTCCCTGGAAAATATCTTCTCAAGGGGAGCTAACAGAATGAGAGGTCGGCTTGGAAGTGTG
GACAGTTTTGAACGGTCCAACAGTCTTGCTTCAGAGAAGGACTACTCACCAGGGGATTCTCCACCAGGGACACCGCCAGCGTCCCCACCG
TCCTCAGCTTGGCAAACGTTTCCCGAAGAGGATTCCGACTCCCCGCAGTTTCGAAGACGGGCACACACGTTCAGCCACCCACCTTCAAGC
ACAAAGAGAAAGCTGAATTTGCAGGATGGGAGGGCTCAGGGTGTGCGTTCCCCTCTGCTGAGGCAGAGCTCCAGTGAACAGTGCAGCAAT
CTTTCGTCAGTTCGACGCATGTACAAGGAGAGTAATTCTTCCTCCAGTCTTCCAAGTCTTCACACTTCCTTCTCTGCCCCTTCCTTCACT
GCCCCCTCTTTCCTGAAAAGCTTTTACCAGAATTCAGGTAGACTGTCCCCACAGTATGAAAATGAAATCAGTGATGGAGAAGGGAGAAAA
AGGACCTCATCTACCTGCAGCAATGAGTCCCTAAGTGTGGGAGGAACCTCTGTCACTCCTCGCCGGATCTCCTGGCGGCAGCGCATTTTC
CTCAGGGTTGCTTCTCCCATGAACAAATCTCCCTCAGCAATGCAACAGCAAGATGGATTGGACAGGAACGAGCTGCTGCCACTGTCCCCC
CTCTCTCCAACCATGGAGGAGGAACCGCTGGTTGTATTCCTGTCTGGGGAGGATGACCCAGAAAAGATTGAAGAAAGAAAGAAATCAAAA
GAACTGAGGAGCTTGTGGAGAAAAGCTATACACCAACAAATCTTGTTACTTCGAATGGAAAAAGAAAACCAGAAACTTGAAGCAAGCAGA
GATGAACTCCAGTCCAGAAAAGTTAAATTAGACTATGAAGAAGTTGGTGCATGTCAGAAAGAGGTCTTAATAACTTGGGATAAGAAGTTG
TTAAACTGCAGAGCTAAAATCAGATGTGATATGGAAGATATTCATACTCTTCTTAAAGAAGGAGTTCCCAAAAGTCGACGAGGAGAAATT
TGGCAGTTTCTGGCTTTACAGTACCGACTCAGACACAGATTGCCTAATAAACAACAGCCTCCTGACATATCCTATAAGGAACTTTTGAAG
CAGCTCACTGCTCAGCAGCATGCGATTCTCGTGGATTTAGGAAGGACGTTTCCTACTCACCCTTACTTTTCAGTACAGCTTGGGCCAGGA
CAGCTGTCACTGTTTAACCTCCTGAAAGCCTATTCTTTGCTGGACAAAGAAGTGGGATACTGTCAGGGGATCAGCTTTGTGGCTGGAGTC
CTGCTTCTGCACATGAGTGAAGAGCAAGCCTTTGAAATGCTGAAATTCCTCATGTATGACCTCGGCTTCCGCAAGCAGTACAGACCTGAC
ATGATGTCGCTGCAGATTCAAATGTACCAGCTGTCCAGGCTCCTTCATGACTATCACAGAGATCTCTACAATCACCTTGAAGAAAATGAA
ATCAGCCCCAGTCTTTATGCTGCCCCCTGGTTCCTCACATTGTTTGCCTCTCAGTTTTCATTAGGATTTGTAGCCAGAGTTTTTGATATT
ATTTTTCTTCAGGGAACTGAAGTTATATTCAAGGTTGCACTCAGCCTACTGAGCAGCCAAGAGACACTTATAATGGAATGTGAGAGCTTT
GAAAATATTGTTGAGTTTCTTAAAAACACGCTACCTGATATGAATACCTCTGAAATGGAAAAAATTATTACCCAGGTTTTTGAGATGGAT
ATTTCTAAGCAGTTGCATGCCTATGAGGTGGAATATCATGTGCTACAGGATGAGCTTCAGGAATCTTCATATTCCTGTGAGGATAGTGAA
ACTTTGGAGAAGCTGGAGAGGGCCAATAGCCAACTGAAAAGACAAAACATGGACCTCCTAGAAAAATTACAGGTAGCTCATACTAAAATC
CAGGCCTTGGAATCAAACCTGGAAAATCTTTTGACGAGAGAGACCAAAATGAAGTCTTTAATCCGGACCCTGGAACAAGAAAAAATGGCT
TATCAAAAGACAGTGGAGCAACTCCGGAAGCTGCTGCCCGCGGATGCTCTAGTCAATTGTGACCTGTTGCTGAGAGACCTAAACTGCAAC
CCTAACAACAAAGCCAAGATAGGAAATAAGCCATAATTGAAGAGGCACGGCCTCAGCAGAAAGTGCTCCTTAGAATACTACAGAGAGGAA
GAGCCTGCATGTCGCTGGCCCAAGGCTGGACCCTGAAGCTGATGGAACCACCTAATACTGGTGCTGAGCGCCTAGTCACAGCAGGTGGAC
CTCGTGCTCATCAGAGCATGCCAATCCTAAGCCATTGGACATATGTAGACTGGTTTTTGTTGTTGCTATGTACATATAAATATATATATA
AAATGAACATAGTTCATGCTTTCAGATAAAATGAGTAGATGTATATTTAGATTAATTTTTTTAGTCAGAACTTCATGAAATCCACACCAA
AGGAAAGGTAAACTGAAATTTCCCTTGGACATATGTGAAATCTTTTTGTCTTTATAGTGAAACAAAGCCAGAGCATCTTTGTATATTGCA
ATATACTTGAAAAAAATGAATGTATTTTTTTCTCCAAAGAACAGCATGTTTCACTCAATGGTGAAAAGGTGGAAACATTTATGTAACTTT
ATGTGTATCTGTCTTGATATCTACTGACATTGTCTATATGAGGAAAATGATTACTGGTCATGCTCCTGTGAGTTTTTTGGGAAGGTAGGG
TCATTTCTCCCTGCCTGCTTTGTGCCAACTAGCATGTTGCATCTACATGCATTATGAGTCTGGTTAGGCATTACTTTAAACATACATAAA
GAGACAGTAGGACATTGTGGCTGAGTCTACCCAGCTCAAGGTAAAGGAGAATGTTGCTAATTTTTTAGCAAACTAGACCAGCATTATTAC
TCAAACTAAAAATATCACACCTGAAAAATTTAATTTAGGACCTAAAATGTCTAGATTAGCTTTCTGCTTTTTTTATTTGAATAACTCATT
CAGTTGTGAATGAATTCCTCTTTATTTGGTGCCACAGTCACCAAATGACAAGGATTTGCCACTTTCCCACCAAATTGTGAGTGCTTGTAA
TTTAGGTCTCTCTACCTTAAATTCAGTATAAGGAAACGTAATTATGATTGATTTTTTCCAAAGATGACAAGCTGTGTTGAAATACATTTT
TTCTTTTGACCAATTGACAGAATCTAATAAGCTTTAATAATCTTCCCCTTTTATGTGAAAAGTTTTGAGAACTGTGAAATGTTTAGGAAC
AAACTGTTGAAATCCATTGGAAGGGAAAAAAGAAAGTGGTACCAGTGTTACCAGCTCAACTAAAACCTGCAATTCTGCATTTCAACTCTT
CACTTCCTCAGCCTACAAATAGCTCATTAGATGACATTCACGCATGCTGGGTATAGGCAAGGAAAGTAATTTTCAAAGTACATTTGCAGT
TCTCTTTTTCAGAGATGATTCTATGATAGTGCCTCTGAAAGTTGATGCAGCATTTTTGCCTTTCCAAAAAGTATTTATCCTCACTGCTTT
TTGCAGTACTTGTATTTTCACAGATGGATTATCTGGGGTAATTTTCTTCAAAGGGAGTTTGTTATACACAGTGAAAATGTATTATAGAGT
AGAATAGTAAAGCTCTAGGGGTTTCAGAAAGCTTTGATGAACAGATGACAAACATCTGAAACCCCCTCCGCACTGTTACCCAGTGTGTAT
ATAATGACTTGTTATAGCTCAGTGTGCCCTTGAATCCATACAGTTTCTTAAAAGACAATAAAATCTTATTAATAAAGTTAATGTAACTTC
TAAGTTCTAGAAAATGCTGATTCTGTCTGCCCCATTCAATTGGGGGCTACTAATTGATTTGTTGCTTGGATTTCCTGAGAATTTCTCTAT
TTGTAGGAGGGGTTTTTTCTTTTTACGGTCTGTTGATGACAATTACTTTATGGGTGTGATGCACCGATGGTAGCCAAGGAATCTGTTGGG
GAAGTTCGGAAAGAAACCTTTTCTTTCTTTTATTCAGTTTAAAGTAAACTTTATCCTGGATGTTTAGAATCAACATTAAGAGTTATATTA
TGGTGTTCAGAGATTAAGCTGACTTGGATACAATATTTTCTTTTGAAAATGAATTTTCTTTTTCATTTGTGATTTTTAAAAAATGTTGCA

>24993_24993_2_EDNRB-TBC1D4_EDNRB_chr13_78473994_ENST00000334286_TBC1D4_chr13_75936743_ENST00000431480_length(amino acids)=1538AA_BP=1
MKLRSGHRTPSGAGSSMQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKG
DRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLA
EDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRI
CLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRI
LKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKF
EVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSS
RVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNF
KDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLY
PPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNK
AKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKR
KLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEISDGEGRKRTS
STCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELR
SLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQF
LALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLL
HMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFL
QGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLE
KLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNCNPNN

--------------------------------------------------------------
>24993_24993_3_EDNRB-TBC1D4_EDNRB_chr13_78473994_ENST00000377211_TBC1D4_chr13_75936743_ENST00000377636_length(transcript)=7136nt_BP=1617nt
AAACAGCCTTTTGGGACCTGTCCCCGGACGAGGACTGCCCCCCTCCCTCGGGCAACTACTACTGATGCTGTCCAGGCATCGCCCAAGGGG
AAAGGTTGCAGCGGGGTCGGAAGGCGCGGGAGGAGTCTGGCGGTGATTGATGGGAAGGGATGAATGAATAAAAGTACTTGTCTGATGGCA
GCAGAGACCCCGAGCAAACGGTGGAGGCTACACTGTCTGGCATTCTCGCAGCGTTTCGTCAGAGCCGGACCCGCCTGCAGCTCAAGGGAG
GCGTGCTCCTCTCCCAGAGCAGGCTGGAACCCAGCTGGGTTCCGCCTCCCGGGAAGGTGGTCTCCATTCGTCGCTCTGCATCTGGTTTGT
CAGATCCGAGAGGCTCTGAAACTGCGGAGCGGCCACCGGACGCCTTCTGGAGCAGGTAGCAGCATGCAGCCGCCTCCAAGTCTGTGCGGA
CGCGCCCTGGTTGCGCTGGTTCTTGCCTGCGGCCTGTCGCGGATCTGGGGAGAGGAGAGAGGCTTCCCGCCTGACAGGGCCACTCCGCTT
TTGCAAACCGCAGAGATAATGACGCCACCCACTAAGACCTTATGGCCCAAGGGTTCCAACGCCAGTCTGGCGCGGTCGTTGGCACCTGCG
GAGGTGCCTAAAGGAGACAGGACGGCAGGATCTCCGCCACGCACCATCTCCCCTCCCCCGTGCCAAGGACCCATCGAGATCAAGGAGACT
TTCAAATACATCAACACGGTTGTGTCCTGCCTTGTGTTCGTGCTGGGGATCATCGGGAACTCCACACTTCTGAGAATTATCTACAAGAAC
AAGTGCATGCGAAACGGTCCCAATATCTTGATCGCCAGCTTGGCTCTGGGAGACCTGCTGCACATCGTCATTGACATCCCTATCAATGTC
TACAAGCTGCTGGCAGAGGACTGGCCATTTGGAGCTGAGATGTGTAAGCTGGTGCCTTTCATACAGAAAGCCTCTGTGGGAATCACTGTG
CTGAGTCTATGTGCTCTGAGTATTGACAGATATCGAGCTGTTGCTTCTTGGAGTAGAATTAAAGGAATTGGGGTTCCAAAATGGACAGCA
GTAGAAATTGTTTTGATTTGGGTGGTCTCTGTGGTTCTGGCTGTCCCTGAAGCCATAGGTTTTGATATAATTACGATGGACTACAAAGGA
AGTTATCTGCGAATCTGCTTGCTTCATCCCGTTCAGAAGACAGCTTTCATGCAGTTTTACAAGACAGCAAAAGATTGGTGGCTATTCAGT
TTCTATTTCTGCTTGCCATTGGCCATCACTGCATTTTTTTATACACTAATGACCTGTGAAATGTTGAGAAAGAAAAGTGGCATGCAGATT
GCTTTAAATGATCACCTAAAGCAGAGACGGGAAGTGGCCAAAACCGTCTTTTGCCTGGTCCTTGTCTTTGCCCTCTGCTGGCTTCCCCTT
CACCTCAGCAGGATTCTGAAGCTCACTCTTTATAATCAGAATGATCCCAATAGATGTGAACTTTTGAGCTTTCTGTTGGTATTGGACTAT
ATTGGTATCAACATGGCTTCACTGAATTCCTGCATTAACCCAATTGCTCTGTATTTGGTGAGCAAAAGATTCAAAAACTGCTTTAAGGTT
CCTGATGTTATTAGCAGCATAAGGCAATTATCTAAAGCGGCCATGAAAGAGGATGCCAAACCCAGCAAAGATAATGAGGACGCCTTTTAC
AACTCTCAGAAGTTCGAAGTCCTGTACTGTGGAAAGGTGACCGTGACCCACAAGAAGGCCCCCTCAAGCCTCATCGATGACTGCATGGAG
AAGTTCAGCCTGCACGAACAGCAGCGCCTGAAGATCCAAGGGGAGCAGCGCGGTCCGGACCCAGGAGAGGACCTGGCTGACTTGGAGGTG
GTGGTGCCCGGGTCCCCCGGAGACTGCCTGCCGGAGGAGGCTGACGGCACCGACACCCACCTTGGCTTACCTGCCGGGGCCAGCCAGCCT
GCCCTGACCAGCTCTCGGGTCTGCTTCCCTGAGCGGATTTTGGAAGATTCTGGCTTTGATGAGCAGCAGGAGTTTCGGTCTCGGTGCAGC
AGTGTCACCGGCGTGCAACGGAGAGTTCACGAGGGCAGCCAGAAATCCCAGCCGCGACGGAGACACGCGAGCGCACCCAGTCACGTCCAG
CCCTCGGACTCGGAGAAGAACAGGACCATGCTCTTCCAGGTTGGGCGATTTGAGATTAACCTTATCAGTCCAGACACTAAATCAGTTGTG
CTAGAAAAGAATTTTAAAGATATCTCCTCTTGTTCTCAGGGTATAAAGCATGTGGATCACTTTGGCTTTATCTGCCGGGAGTCTCCAGAG
CCTGGACTTAGCCAGTATATTTGTTATGTATTCCAGTGTGCCAGCGAATCTCTGGTTGATGAGGTAATGCTGACTCTGAAACAGGCCTTC
AGTACGGCGGCTGCCCTGCAGAGTGCCAAGACGCAGATTAAACTGTGTGAGGCCTGCCCGATGCACTCTTTGCATAAGCTCTGTGAAAGG
ATTGAAGGTCTCTACCCACCAAGAGCCAAGCTGGTGATACAGAGGCATCTCTCATCACTGACAGATAATGAGCAAGCTGACATCTTTGAA
AGAGTTCAGAAAATGAAGCCAGTCAGTGACCAGGAAGAAAATGAACTTGTGATTTTACACCTGAGGCAGCTGTGTGAAGCCAAGCAGAAG
ACACACGTGCACATCGGGGAAGGCCCTTCTACTATTTCAAATAGTACAATCCCAGAAAATGCAACAAGCAGTGGAAGGTTCAAACTTGAC
ATTCTGAAAAATAAAGCTAAGAGATCCTTAACTAGCTCCCTGGAAAATATCTTCTCAAGGGGAGCTAACAGAATGAGAGGTCGGCTTGGA
AGTGTGGACAGTTTTGAACGGTCCAACAGTCTTGCTTCAGAGAAGGACTACTCACCAGGGGATTCTCCACCAGGGACACCGCCAGCGTCC
CCACCGTCCTCAGCTTGGCAAACGTTTCCCGAAGAGGATTCCGACTCCCCGCAGTTTCGAAGACGGGCACACACGTTCAGCCACCCACCT
TCAAGCACAAAGAGAAAGCTGAATTTGCAGGATGGGAGGGCTCAGGGTGTGCGTTCCCCTCTGCTGAGGCAGAGCTCCAGTGAACAGTGC
AGCAATCTTTCGTCAGTTCGACGCATGTACAAGGAGAGTAATTCTTCCTCCAGTCTTCCAAGTCTTCACACTTCCTTCTCTGCCCCTTCC
TTCACTGCCCCCTCTTTCCTGAAAAGCTTTTACCAGAATTCAGGTAGACTGTCCCCACAGTATGAAAATGAAATCAGACAAGACACTGCT
TCAGAATCAAGTGATGGAGAAGGGAGAAAAAGGACCTCATCTACCTGCAGCAATGAGTCCCTAAGTGTGGGAGGAACCTCTGTCACTCCT
CGCCGGATCTCCTGGCGGCAGCGCATTTTCCTCAGGGTTGCTTCTCCCATGAACAAATCTCCCTCAGCAATGCAACAGCAAGATGGATTG
GACAGGAACGAGCTGCTGCCACTGTCCCCCCTCTCTCCAACCATGGAGGAGGAACCGCTGGTTGTATTCCTGTCTGGGGAGGATGACCCA
GAAAAGATTGAAGAAAGAAAGAAATCAAAAGAACTGAGGAGCTTGTGGAGAAAAGCTATACACCAACAAATCTTGTTACTTCGAATGGAA
AAAGAAAACCAGAAACTTGAAGCAAGCAGAGATGAACTCCAGTCCAGAAAAGTTAAATTAGACTATGAAGAAGTTGGTGCATGTCAGAAA
GAGGTCTTAATAACTTGGGATAAGAAGTTGTTAAACTGCAGAGCTAAAATCAGATGTGATATGGAAGATATTCATACTCTTCTTAAAGAA
GGAGTTCCCAAAAGTCGACGAGGAGAAATTTGGCAGTTTCTGGCTTTACAGTACCGACTCAGACACAGATTGCCTAATAAACAACAGCCT
CCTGACATATCCTATAAGGAACTTTTGAAGCAGCTCACTGCTCAGCAGCATGCGATTCTCGTGGATTTAGGAAGGACGTTTCCTACTCAC
CCTTACTTTTCAGTACAGCTTGGGCCAGGACAGCTGTCACTGTTTAACCTCCTGAAAGCCTATTCTTTGCTGGACAAAGAAGTGGGATAC
TGTCAGGGGATCAGCTTTGTGGCTGGAGTCCTGCTTCTGCACATGAGTGAAGAGCAAGCCTTTGAAATGCTGAAATTCCTCATGTATGAC
CTCGGCTTCCGCAAGCAGTACAGACCTGACATGATGTCGCTGCAGATTCAAATGTACCAGCTGTCCAGGCTCCTTCATGACTATCACAGA
GATCTCTACAATCACCTTGAAGAAAATGAAATCAGCCCCAGTCTTTATGCTGCCCCCTGGTTCCTCACATTGTTTGCCTCTCAGTTTTCA
TTAGGATTTGTAGCCAGAGTTTTTGATATTATTTTTCTTCAGGGAACTGAAGTTATATTCAAGGTTGCACTCAGCCTACTGAGCAGCCAA
GAGACACTTATAATGGAATGTGAGAGCTTTGAAAATATTGTTGAGTTTCTTAAAAACACGCTACCTGATATGAATACCTCTGAAATGGAA
AAAATTATTACCCAGGTTTTTGAGATGGATATTTCTAAGCAGTTGCATGCCTATGAGGTGGAATATCATGTGCTACAGGATGAGCTTCAG
GAATCTTCATATTCCTGTGAGGATAGTGAAACTTTGGAGAAGCTGGAGAGGGCCAATAGCCAACTGAAAAGACAAAACATGGACCTCCTA
GAAAAATTACAGGTAGCTCATACTAAAATCCAGGCCTTGGAATCAAACCTGGAAAATCTTTTGACGAGAGAGACCAAAATGAAGTCTTTA
ATCCGGACCCTGGAACAAGAAAAAATGGCTTATCAAAAGACAGTGGAGCAACTCCGGAAGCTGCTGCCCGCGGATGCTCTAGTCAATTGT
GACCTGTTGCTGAGAGACCTAAACTGCAACCCTAACAACAAAGCCAAGATAGGAAATAAGCCATAATTGAAGAGGCACGGCCTCAGCAGA
AAGTGCTCCTTAGAATACTACAGAGAGGAAGAGCCTGCATGTCGCTGGCCCAAGGCTGGACCCTGAAGCTGATGGAACCACCTAATACTG
GTGCTGAGCGCCTAGTCACAGCAGGTGGACCTCGTGCTCATCAGAGCATGCCAATCCTAAGCCATTGGACATATGTAGACTGGTTTTTGT
TGTTGCTATGTACATATAAATATATATATAAAATGAACATAGTTCATGCTTTCAGATAAAATGAGTAGATGTATATTTAGATTAATTTTT
TTAGTCAGAACTTCATGAAATCCACACCAAAGGAAAGGTAAACTGAAATTTCCCTTGGACATATGTGAAATCTTTTTGTCTTTATAGTGA
AACAAAGCCAGAGCATCTTTGTATATTGCAATATACTTGAAAAAAATGAATGTATTTTTTTCTCCAAAGAACAGCATGTTTCACTCAATG
GTGAAAAGGTGGAAACATTTATGTAACTTTATGTGTATCTGTCTTGATATCTACTGACATTGTCTATATGAGGAAAATGATTACTGGTCA
TGCTCCTGTGAGTTTTTTGGGAAGGTAGGGTCATTTCTCCCTGCCTGCTTTGTGCCAACTAGCATGTTGCATCTACATGCATTATGAGTC
TGGTTAGGCATTACTTTAAACATACATAAAGAGACAGTAGGACATTGTGGCTGAGTCTACCCAGCTCAAGGTAAAGGAGAATGTTGCTAA
TTTTTTAGCAAACTAGACCAGCATTATTACTCAAACTAAAAATATCACACCTGAAAAATTTAATTTAGGACCTAAAATGTCTAGATTAGC
TTTCTGCTTTTTTTATTTGAATAACTCATTCAGTTGTGAATGAATTCCTCTTTATTTGGTGCCACAGTCACCAAATGACAAGGATTTGCC
ACTTTCCCACCAAATTGTGAGTGCTTGTAATTTAGGTCTCTCTACCTTAAATTCAGTATAAGGAAACGTAATTATGATTGATTTTTTCCA
AAGATGACAAGCTGTGTTGAAATACATTTTTTCTTTTGACCAATTGACAGAATCTAATAAGCTTTAATAATCTTCCCCTTTTATGTGAAA
AGTTTTGAGAACTGTGAAATGTTTAGGAACAAACTGTTGAAATCCATTGGAAGGGAAAAAAGAAAGTGGTACCAGTGTTACCAGCTCAAC
TAAAACCTGCAATTCTGCATTTCAACTCTTCACTTCCTCAGCCTACAAATAGCTCATTAGATGACATTCACGCATGCTGGGTATAGGCAA
GGAAAGTAATTTTCAAAGTACATTTGCAGTTCTCTTTTTCAGAGATGATTCTATGATAGTGCCTCTGAAAGTTGATGCAGCATTTTTGCC
TTTCCAAAAAGTATTTATCCTCACTGCTTTTTGCAGTACTTGTATTTTCACAGATGGATTATCTGGGGTAATTTTCTTCAAAGGGAGTTT
GTTATACACAGTGAAAATGTATTATAGAGTAGAATAGTAAAGCTCTAGGGGTTTCAGAAAGCTTTGATGAACAGATGACAAACATCTGAA
ACCCCCTCCGCACTGTTACCCAGTGTGTATATAATGACTTGTTATAGCTCAGTGTGCCCTTGAATCCATACAGTTTCTTAAAAGACAATA
AAATCTTATTAATAAAGTTAATGTAACTTCTAAGTTCTAGAAAATGCTGATTCTGTCTGCCCCATTCAATTGGGGGCTACTAATTGATTT
GTTGCTTGGATTTCCTGAGAATTTCTCTATTTGTAGGAGGGGTTTTTTCTTTTTACGGTCTGTTGATGACAATTACTTTATGGGTGTGAT
GCACCGATGGTAGCCAAGGAATCTGTTGGGGAAGTTCGGAAAGAAACCTTTTCTTTCTTTTATTCAGTTTAAAGTAAACTTTATCCTGGA
TGTTTAGAATCAACATTAAGAGTTATATTATGGTGTTCAGAGATTAAGCTGACTTGGATACAATATTTTCTTTTGAAAATGAATTTTCTT
TTTCATTTGTGATTTTTAAAAAATGTTGCACCAGTTATGCTTCATGCATCGTTACATCTTCATCAGGTTAATGTAATGTCTAGTTCCTTT

>24993_24993_3_EDNRB-TBC1D4_EDNRB_chr13_78473994_ENST00000377211_TBC1D4_chr13_75936743_ENST00000377636_length(amino acids)=1620AA_BP=0
MNKSTCLMAAETPSKRWRLHCLAFSQRFVRAGPACSSREACSSPRAGWNPAGFRLPGRWSPFVALHLVCQIREALKLRSGHRTPSGAGSS
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPC
QGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYK
TAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAP
SSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDE
QQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHF
GFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLT
DNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRG
ANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPL
LRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESL
SVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIH
QQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLR
HRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAF
EMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFK
VALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQ
LKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP

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>24993_24993_4_EDNRB-TBC1D4_EDNRB_chr13_78473994_ENST00000377211_TBC1D4_chr13_75936743_ENST00000431480_length(transcript)=7111nt_BP=1617nt
AAACAGCCTTTTGGGACCTGTCCCCGGACGAGGACTGCCCCCCTCCCTCGGGCAACTACTACTGATGCTGTCCAGGCATCGCCCAAGGGG
AAAGGTTGCAGCGGGGTCGGAAGGCGCGGGAGGAGTCTGGCGGTGATTGATGGGAAGGGATGAATGAATAAAAGTACTTGTCTGATGGCA
GCAGAGACCCCGAGCAAACGGTGGAGGCTACACTGTCTGGCATTCTCGCAGCGTTTCGTCAGAGCCGGACCCGCCTGCAGCTCAAGGGAG
GCGTGCTCCTCTCCCAGAGCAGGCTGGAACCCAGCTGGGTTCCGCCTCCCGGGAAGGTGGTCTCCATTCGTCGCTCTGCATCTGGTTTGT
CAGATCCGAGAGGCTCTGAAACTGCGGAGCGGCCACCGGACGCCTTCTGGAGCAGGTAGCAGCATGCAGCCGCCTCCAAGTCTGTGCGGA
CGCGCCCTGGTTGCGCTGGTTCTTGCCTGCGGCCTGTCGCGGATCTGGGGAGAGGAGAGAGGCTTCCCGCCTGACAGGGCCACTCCGCTT
TTGCAAACCGCAGAGATAATGACGCCACCCACTAAGACCTTATGGCCCAAGGGTTCCAACGCCAGTCTGGCGCGGTCGTTGGCACCTGCG
GAGGTGCCTAAAGGAGACAGGACGGCAGGATCTCCGCCACGCACCATCTCCCCTCCCCCGTGCCAAGGACCCATCGAGATCAAGGAGACT
TTCAAATACATCAACACGGTTGTGTCCTGCCTTGTGTTCGTGCTGGGGATCATCGGGAACTCCACACTTCTGAGAATTATCTACAAGAAC
AAGTGCATGCGAAACGGTCCCAATATCTTGATCGCCAGCTTGGCTCTGGGAGACCTGCTGCACATCGTCATTGACATCCCTATCAATGTC
TACAAGCTGCTGGCAGAGGACTGGCCATTTGGAGCTGAGATGTGTAAGCTGGTGCCTTTCATACAGAAAGCCTCTGTGGGAATCACTGTG
CTGAGTCTATGTGCTCTGAGTATTGACAGATATCGAGCTGTTGCTTCTTGGAGTAGAATTAAAGGAATTGGGGTTCCAAAATGGACAGCA
GTAGAAATTGTTTTGATTTGGGTGGTCTCTGTGGTTCTGGCTGTCCCTGAAGCCATAGGTTTTGATATAATTACGATGGACTACAAAGGA
AGTTATCTGCGAATCTGCTTGCTTCATCCCGTTCAGAAGACAGCTTTCATGCAGTTTTACAAGACAGCAAAAGATTGGTGGCTATTCAGT
TTCTATTTCTGCTTGCCATTGGCCATCACTGCATTTTTTTATACACTAATGACCTGTGAAATGTTGAGAAAGAAAAGTGGCATGCAGATT
GCTTTAAATGATCACCTAAAGCAGAGACGGGAAGTGGCCAAAACCGTCTTTTGCCTGGTCCTTGTCTTTGCCCTCTGCTGGCTTCCCCTT
CACCTCAGCAGGATTCTGAAGCTCACTCTTTATAATCAGAATGATCCCAATAGATGTGAACTTTTGAGCTTTCTGTTGGTATTGGACTAT
ATTGGTATCAACATGGCTTCACTGAATTCCTGCATTAACCCAATTGCTCTGTATTTGGTGAGCAAAAGATTCAAAAACTGCTTTAAGGTT
CCTGATGTTATTAGCAGCATAAGGCAATTATCTAAAGCGGCCATGAAAGAGGATGCCAAACCCAGCAAAGATAATGAGGACGCCTTTTAC
AACTCTCAGAAGTTCGAAGTCCTGTACTGTGGAAAGGTGACCGTGACCCACAAGAAGGCCCCCTCAAGCCTCATCGATGACTGCATGGAG
AAGTTCAGCCTGCACGAACAGCAGCGCCTGAAGATCCAAGGGGAGCAGCGCGGTCCGGACCCAGGAGAGGACCTGGCTGACTTGGAGGTG
GTGGTGCCCGGGTCCCCCGGAGACTGCCTGCCGGAGGAGGCTGACGGCACCGACACCCACCTTGGCTTACCTGCCGGGGCCAGCCAGCCT
GCCCTGACCAGCTCTCGGGTCTGCTTCCCTGAGCGGATTTTGGAAGATTCTGGCTTTGATGAGCAGCAGGAGTTTCGGTCTCGGTGCAGC
AGTGTCACCGGCGTGCAACGGAGAGTTCACGAGGGCAGCCAGAAATCCCAGCCGCGACGGAGACACGCGAGCGCACCCAGTCACGTCCAG
CCCTCGGACTCGGAGAAGAACAGGACCATGCTCTTCCAGGTTGGGCGATTTGAGATTAACCTTATCAGTCCAGACACTAAATCAGTTGTG
CTAGAAAAGAATTTTAAAGATATCTCCTCTTGTTCTCAGGGTATAAAGCATGTGGATCACTTTGGCTTTATCTGCCGGGAGTCTCCAGAG
CCTGGACTTAGCCAGTATATTTGTTATGTATTCCAGTGTGCCAGCGAATCTCTGGTTGATGAGGTAATGCTGACTCTGAAACAGGCCTTC
AGTACGGCGGCTGCCCTGCAGAGTGCCAAGACGCAGATTAAACTGTGTGAGGCCTGCCCGATGCACTCTTTGCATAAGCTCTGTGAAAGG
ATTGAAGGTCTCTACCCACCAAGAGCCAAGCTGGTGATACAGAGGCATCTCTCATCACTGACAGATAATGAGCAAGCTGACATCTTTGAA
AGAGTTCAGAAAATGAAGCCAGTCAGTGACCAGGAAGAAAATGAACTTGTGATTTTACACCTGAGGCAGCTGTGTGAAGCCAAGCAGAAG
ACACACGTGCACATCGGGGAAGGCCCTTCTACTATTTCAAATAGTACAATCCCAGAAAATGCAACAAGCAGTGGAAGGTTCAAACTTGAC
ATTCTGAAAAATAAAGCTAAGAGATCCTTAACTAGCTCCCTGGAAAATATCTTCTCAAGGGGAGCTAACAGAATGAGAGGTCGGCTTGGA
AGTGTGGACAGTTTTGAACGGTCCAACAGTCTTGCTTCAGAGAAGGACTACTCACCAGGGGATTCTCCACCAGGGACACCGCCAGCGTCC
CCACCGTCCTCAGCTTGGCAAACGTTTCCCGAAGAGGATTCCGACTCCCCGCAGTTTCGAAGACGGGCACACACGTTCAGCCACCCACCT
TCAAGCACAAAGAGAAAGCTGAATTTGCAGGATGGGAGGGCTCAGGGTGTGCGTTCCCCTCTGCTGAGGCAGAGCTCCAGTGAACAGTGC
AGCAATCTTTCGTCAGTTCGACGCATGTACAAGGAGAGTAATTCTTCCTCCAGTCTTCCAAGTCTTCACACTTCCTTCTCTGCCCCTTCC
TTCACTGCCCCCTCTTTCCTGAAAAGCTTTTACCAGAATTCAGGTAGACTGTCCCCACAGTATGAAAATGAAATCAGTGATGGAGAAGGG
AGAAAAAGGACCTCATCTACCTGCAGCAATGAGTCCCTAAGTGTGGGAGGAACCTCTGTCACTCCTCGCCGGATCTCCTGGCGGCAGCGC
ATTTTCCTCAGGGTTGCTTCTCCCATGAACAAATCTCCCTCAGCAATGCAACAGCAAGATGGATTGGACAGGAACGAGCTGCTGCCACTG
TCCCCCCTCTCTCCAACCATGGAGGAGGAACCGCTGGTTGTATTCCTGTCTGGGGAGGATGACCCAGAAAAGATTGAAGAAAGAAAGAAA
TCAAAAGAACTGAGGAGCTTGTGGAGAAAAGCTATACACCAACAAATCTTGTTACTTCGAATGGAAAAAGAAAACCAGAAACTTGAAGCA
AGCAGAGATGAACTCCAGTCCAGAAAAGTTAAATTAGACTATGAAGAAGTTGGTGCATGTCAGAAAGAGGTCTTAATAACTTGGGATAAG
AAGTTGTTAAACTGCAGAGCTAAAATCAGATGTGATATGGAAGATATTCATACTCTTCTTAAAGAAGGAGTTCCCAAAAGTCGACGAGGA
GAAATTTGGCAGTTTCTGGCTTTACAGTACCGACTCAGACACAGATTGCCTAATAAACAACAGCCTCCTGACATATCCTATAAGGAACTT
TTGAAGCAGCTCACTGCTCAGCAGCATGCGATTCTCGTGGATTTAGGAAGGACGTTTCCTACTCACCCTTACTTTTCAGTACAGCTTGGG
CCAGGACAGCTGTCACTGTTTAACCTCCTGAAAGCCTATTCTTTGCTGGACAAAGAAGTGGGATACTGTCAGGGGATCAGCTTTGTGGCT
GGAGTCCTGCTTCTGCACATGAGTGAAGAGCAAGCCTTTGAAATGCTGAAATTCCTCATGTATGACCTCGGCTTCCGCAAGCAGTACAGA
CCTGACATGATGTCGCTGCAGATTCAAATGTACCAGCTGTCCAGGCTCCTTCATGACTATCACAGAGATCTCTACAATCACCTTGAAGAA
AATGAAATCAGCCCCAGTCTTTATGCTGCCCCCTGGTTCCTCACATTGTTTGCCTCTCAGTTTTCATTAGGATTTGTAGCCAGAGTTTTT
GATATTATTTTTCTTCAGGGAACTGAAGTTATATTCAAGGTTGCACTCAGCCTACTGAGCAGCCAAGAGACACTTATAATGGAATGTGAG
AGCTTTGAAAATATTGTTGAGTTTCTTAAAAACACGCTACCTGATATGAATACCTCTGAAATGGAAAAAATTATTACCCAGGTTTTTGAG
ATGGATATTTCTAAGCAGTTGCATGCCTATGAGGTGGAATATCATGTGCTACAGGATGAGCTTCAGGAATCTTCATATTCCTGTGAGGAT
AGTGAAACTTTGGAGAAGCTGGAGAGGGCCAATAGCCAACTGAAAAGACAAAACATGGACCTCCTAGAAAAATTACAGGTAGCTCATACT
AAAATCCAGGCCTTGGAATCAAACCTGGAAAATCTTTTGACGAGAGAGACCAAAATGAAGTCTTTAATCCGGACCCTGGAACAAGAAAAA
ATGGCTTATCAAAAGACAGTGGAGCAACTCCGGAAGCTGCTGCCCGCGGATGCTCTAGTCAATTGTGACCTGTTGCTGAGAGACCTAAAC
TGCAACCCTAACAACAAAGCCAAGATAGGAAATAAGCCATAATTGAAGAGGCACGGCCTCAGCAGAAAGTGCTCCTTAGAATACTACAGA
GAGGAAGAGCCTGCATGTCGCTGGCCCAAGGCTGGACCCTGAAGCTGATGGAACCACCTAATACTGGTGCTGAGCGCCTAGTCACAGCAG
GTGGACCTCGTGCTCATCAGAGCATGCCAATCCTAAGCCATTGGACATATGTAGACTGGTTTTTGTTGTTGCTATGTACATATAAATATA
TATATAAAATGAACATAGTTCATGCTTTCAGATAAAATGAGTAGATGTATATTTAGATTAATTTTTTTAGTCAGAACTTCATGAAATCCA
CACCAAAGGAAAGGTAAACTGAAATTTCCCTTGGACATATGTGAAATCTTTTTGTCTTTATAGTGAAACAAAGCCAGAGCATCTTTGTAT
ATTGCAATATACTTGAAAAAAATGAATGTATTTTTTTCTCCAAAGAACAGCATGTTTCACTCAATGGTGAAAAGGTGGAAACATTTATGT
AACTTTATGTGTATCTGTCTTGATATCTACTGACATTGTCTATATGAGGAAAATGATTACTGGTCATGCTCCTGTGAGTTTTTTGGGAAG
GTAGGGTCATTTCTCCCTGCCTGCTTTGTGCCAACTAGCATGTTGCATCTACATGCATTATGAGTCTGGTTAGGCATTACTTTAAACATA
CATAAAGAGACAGTAGGACATTGTGGCTGAGTCTACCCAGCTCAAGGTAAAGGAGAATGTTGCTAATTTTTTAGCAAACTAGACCAGCAT
TATTACTCAAACTAAAAATATCACACCTGAAAAATTTAATTTAGGACCTAAAATGTCTAGATTAGCTTTCTGCTTTTTTTATTTGAATAA
CTCATTCAGTTGTGAATGAATTCCTCTTTATTTGGTGCCACAGTCACCAAATGACAAGGATTTGCCACTTTCCCACCAAATTGTGAGTGC
TTGTAATTTAGGTCTCTCTACCTTAAATTCAGTATAAGGAAACGTAATTATGATTGATTTTTTCCAAAGATGACAAGCTGTGTTGAAATA
CATTTTTTCTTTTGACCAATTGACAGAATCTAATAAGCTTTAATAATCTTCCCCTTTTATGTGAAAAGTTTTGAGAACTGTGAAATGTTT
AGGAACAAACTGTTGAAATCCATTGGAAGGGAAAAAAGAAAGTGGTACCAGTGTTACCAGCTCAACTAAAACCTGCAATTCTGCATTTCA
ACTCTTCACTTCCTCAGCCTACAAATAGCTCATTAGATGACATTCACGCATGCTGGGTATAGGCAAGGAAAGTAATTTTCAAAGTACATT
TGCAGTTCTCTTTTTCAGAGATGATTCTATGATAGTGCCTCTGAAAGTTGATGCAGCATTTTTGCCTTTCCAAAAAGTATTTATCCTCAC
TGCTTTTTGCAGTACTTGTATTTTCACAGATGGATTATCTGGGGTAATTTTCTTCAAAGGGAGTTTGTTATACACAGTGAAAATGTATTA
TAGAGTAGAATAGTAAAGCTCTAGGGGTTTCAGAAAGCTTTGATGAACAGATGACAAACATCTGAAACCCCCTCCGCACTGTTACCCAGT
GTGTATATAATGACTTGTTATAGCTCAGTGTGCCCTTGAATCCATACAGTTTCTTAAAAGACAATAAAATCTTATTAATAAAGTTAATGT
AACTTCTAAGTTCTAGAAAATGCTGATTCTGTCTGCCCCATTCAATTGGGGGCTACTAATTGATTTGTTGCTTGGATTTCCTGAGAATTT
CTCTATTTGTAGGAGGGGTTTTTTCTTTTTACGGTCTGTTGATGACAATTACTTTATGGGTGTGATGCACCGATGGTAGCCAAGGAATCT
GTTGGGGAAGTTCGGAAAGAAACCTTTTCTTTCTTTTATTCAGTTTAAAGTAAACTTTATCCTGGATGTTTAGAATCAACATTAAGAGTT
ATATTATGGTGTTCAGAGATTAAGCTGACTTGGATACAATATTTTCTTTTGAAAATGAATTTTCTTTTTCATTTGTGATTTTTAAAAAAT
GTTGCACCAGTTATGCTTCATGCATCGTTACATCTTCATCAGGTTAATGTAATGTCTAGTTCCTTTGCAATAAATATATTGCTGCAGCTT

>24993_24993_4_EDNRB-TBC1D4_EDNRB_chr13_78473994_ENST00000377211_TBC1D4_chr13_75936743_ENST00000431480_length(amino acids)=1612AA_BP=0
MNKSTCLMAAETPSKRWRLHCLAFSQRFVRAGPACSSREACSSPRAGWNPAGFRLPGRWSPFVALHLVCQIREALKLRSGHRTPSGAGSS
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPC
QGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYK
TAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAP
SSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDE
QQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHF
GFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLT
DNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRG
ANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPL
LRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEISDGEGRKRTSSTCSNESLSVGGTSVT
PRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRM
EKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQ
PPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMY
DLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSS
QETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDL

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>24993_24993_5_EDNRB-TBC1D4_EDNRB_chr13_78473994_ENST00000446573_TBC1D4_chr13_75936743_ENST00000377636_length(transcript)=6971nt_BP=1452nt
AAGAAAAACAGCTGAGAGGGCATCAGGAAGGAGTTTCGACCCGCGCTGGCGAGTCATGAGCGCCAAGTTTCCCACTGGCGCGCAAACTTG
AGTTACTTTTGAGCGTGGATACTGGCGAAGAGGCTGCGGGCGGTATTAGCGTTTGCAGCGACTTGGCTCGGGCAGCTGACCCAAGTGTCC
TGTCTTCCTTCCTCTGCTTGTCTCTAGGCTCTGAAACTGCGGAGCGGCCACCGGACGCCTTCTGGAGCAGGTAGCAGCATGCAGCCGCCT
CCAAGTCTGTGCGGACGCGCCCTGGTTGCGCTGGTTCTTGCCTGCGGCCTGTCGCGGATCTGGGGAGAGGAGAGAGGCTTCCCGCCTGAC
AGGGCCACTCCGCTTTTGCAAACCGCAGAGATAATGACGCCACCCACTAAGACCTTATGGCCCAAGGGTTCCAACGCCAGTCTGGCGCGG
TCGTTGGCACCTGCGGAGGTGCCTAAAGGAGACAGGACGGCAGGATCTCCGCCACGCACCATCTCCCCTCCCCCGTGCCAAGGACCCATC
GAGATCAAGGAGACTTTCAAATACATCAACACGGTTGTGTCCTGCCTTGTGTTCGTGCTGGGGATCATCGGGAACTCCACACTTCTGAGA
ATTATCTACAAGAACAAGTGCATGCGAAACGGTCCCAATATCTTGATCGCCAGCTTGGCTCTGGGAGACCTGCTGCACATCGTCATTGAC
ATCCCTATCAATGTCTACAAGCTGCTGGCAGAGGACTGGCCATTTGGAGCTGAGATGTGTAAGCTGGTGCCTTTCATACAGAAAGCCTCT
GTGGGAATCACTGTGCTGAGTCTATGTGCTCTGAGTATTGACAGATATCGAGCTGTTGCTTCTTGGAGTAGAATTAAAGGAATTGGGGTT
CCAAAATGGACAGCAGTAGAAATTGTTTTGATTTGGGTGGTCTCTGTGGTTCTGGCTGTCCCTGAAGCCATAGGTTTTGATATAATTACG
ATGGACTACAAAGGAAGTTATCTGCGAATCTGCTTGCTTCATCCCGTTCAGAAGACAGCTTTCATGCAGTTTTACAAGACAGCAAAAGAT
TGGTGGCTATTCAGTTTCTATTTCTGCTTGCCATTGGCCATCACTGCATTTTTTTATACACTAATGACCTGTGAAATGTTGAGAAAGAAA
AGTGGCATGCAGATTGCTTTAAATGATCACCTAAAGCAGAGACGGGAAGTGGCCAAAACCGTCTTTTGCCTGGTCCTTGTCTTTGCCCTC
TGCTGGCTTCCCCTTCACCTCAGCAGGATTCTGAAGCTCACTCTTTATAATCAGAATGATCCCAATAGATGTGAACTTTTGAGCTTTCTG
TTGGTATTGGACTATATTGGTATCAACATGGCTTCACTGAATTCCTGCATTAACCCAATTGCTCTGTATTTGGTGAGCAAAAGATTCAAA
AACTGCTTTAAGGTTCCTGATGTTATTAGCAGCATAAGGCAATTATCTAAAGCGGCCATGAAAGAGGATGCCAAACCCAGCAAAGATAAT
GAGGACGCCTTTTACAACTCTCAGAAGTTCGAAGTCCTGTACTGTGGAAAGGTGACCGTGACCCACAAGAAGGCCCCCTCAAGCCTCATC
GATGACTGCATGGAGAAGTTCAGCCTGCACGAACAGCAGCGCCTGAAGATCCAAGGGGAGCAGCGCGGTCCGGACCCAGGAGAGGACCTG
GCTGACTTGGAGGTGGTGGTGCCCGGGTCCCCCGGAGACTGCCTGCCGGAGGAGGCTGACGGCACCGACACCCACCTTGGCTTACCTGCC
GGGGCCAGCCAGCCTGCCCTGACCAGCTCTCGGGTCTGCTTCCCTGAGCGGATTTTGGAAGATTCTGGCTTTGATGAGCAGCAGGAGTTT
CGGTCTCGGTGCAGCAGTGTCACCGGCGTGCAACGGAGAGTTCACGAGGGCAGCCAGAAATCCCAGCCGCGACGGAGACACGCGAGCGCA
CCCAGTCACGTCCAGCCCTCGGACTCGGAGAAGAACAGGACCATGCTCTTCCAGGTTGGGCGATTTGAGATTAACCTTATCAGTCCAGAC
ACTAAATCAGTTGTGCTAGAAAAGAATTTTAAAGATATCTCCTCTTGTTCTCAGGGTATAAAGCATGTGGATCACTTTGGCTTTATCTGC
CGGGAGTCTCCAGAGCCTGGACTTAGCCAGTATATTTGTTATGTATTCCAGTGTGCCAGCGAATCTCTGGTTGATGAGGTAATGCTGACT
CTGAAACAGGCCTTCAGTACGGCGGCTGCCCTGCAGAGTGCCAAGACGCAGATTAAACTGTGTGAGGCCTGCCCGATGCACTCTTTGCAT
AAGCTCTGTGAAAGGATTGAAGGTCTCTACCCACCAAGAGCCAAGCTGGTGATACAGAGGCATCTCTCATCACTGACAGATAATGAGCAA
GCTGACATCTTTGAAAGAGTTCAGAAAATGAAGCCAGTCAGTGACCAGGAAGAAAATGAACTTGTGATTTTACACCTGAGGCAGCTGTGT
GAAGCCAAGCAGAAGACACACGTGCACATCGGGGAAGGCCCTTCTACTATTTCAAATAGTACAATCCCAGAAAATGCAACAAGCAGTGGA
AGGTTCAAACTTGACATTCTGAAAAATAAAGCTAAGAGATCCTTAACTAGCTCCCTGGAAAATATCTTCTCAAGGGGAGCTAACAGAATG
AGAGGTCGGCTTGGAAGTGTGGACAGTTTTGAACGGTCCAACAGTCTTGCTTCAGAGAAGGACTACTCACCAGGGGATTCTCCACCAGGG
ACACCGCCAGCGTCCCCACCGTCCTCAGCTTGGCAAACGTTTCCCGAAGAGGATTCCGACTCCCCGCAGTTTCGAAGACGGGCACACACG
TTCAGCCACCCACCTTCAAGCACAAAGAGAAAGCTGAATTTGCAGGATGGGAGGGCTCAGGGTGTGCGTTCCCCTCTGCTGAGGCAGAGC
TCCAGTGAACAGTGCAGCAATCTTTCGTCAGTTCGACGCATGTACAAGGAGAGTAATTCTTCCTCCAGTCTTCCAAGTCTTCACACTTCC
TTCTCTGCCCCTTCCTTCACTGCCCCCTCTTTCCTGAAAAGCTTTTACCAGAATTCAGGTAGACTGTCCCCACAGTATGAAAATGAAATC
AGACAAGACACTGCTTCAGAATCAAGTGATGGAGAAGGGAGAAAAAGGACCTCATCTACCTGCAGCAATGAGTCCCTAAGTGTGGGAGGA
ACCTCTGTCACTCCTCGCCGGATCTCCTGGCGGCAGCGCATTTTCCTCAGGGTTGCTTCTCCCATGAACAAATCTCCCTCAGCAATGCAA
CAGCAAGATGGATTGGACAGGAACGAGCTGCTGCCACTGTCCCCCCTCTCTCCAACCATGGAGGAGGAACCGCTGGTTGTATTCCTGTCT
GGGGAGGATGACCCAGAAAAGATTGAAGAAAGAAAGAAATCAAAAGAACTGAGGAGCTTGTGGAGAAAAGCTATACACCAACAAATCTTG
TTACTTCGAATGGAAAAAGAAAACCAGAAACTTGAAGCAAGCAGAGATGAACTCCAGTCCAGAAAAGTTAAATTAGACTATGAAGAAGTT
GGTGCATGTCAGAAAGAGGTCTTAATAACTTGGGATAAGAAGTTGTTAAACTGCAGAGCTAAAATCAGATGTGATATGGAAGATATTCAT
ACTCTTCTTAAAGAAGGAGTTCCCAAAAGTCGACGAGGAGAAATTTGGCAGTTTCTGGCTTTACAGTACCGACTCAGACACAGATTGCCT
AATAAACAACAGCCTCCTGACATATCCTATAAGGAACTTTTGAAGCAGCTCACTGCTCAGCAGCATGCGATTCTCGTGGATTTAGGAAGG
ACGTTTCCTACTCACCCTTACTTTTCAGTACAGCTTGGGCCAGGACAGCTGTCACTGTTTAACCTCCTGAAAGCCTATTCTTTGCTGGAC
AAAGAAGTGGGATACTGTCAGGGGATCAGCTTTGTGGCTGGAGTCCTGCTTCTGCACATGAGTGAAGAGCAAGCCTTTGAAATGCTGAAA
TTCCTCATGTATGACCTCGGCTTCCGCAAGCAGTACAGACCTGACATGATGTCGCTGCAGATTCAAATGTACCAGCTGTCCAGGCTCCTT
CATGACTATCACAGAGATCTCTACAATCACCTTGAAGAAAATGAAATCAGCCCCAGTCTTTATGCTGCCCCCTGGTTCCTCACATTGTTT
GCCTCTCAGTTTTCATTAGGATTTGTAGCCAGAGTTTTTGATATTATTTTTCTTCAGGGAACTGAAGTTATATTCAAGGTTGCACTCAGC
CTACTGAGCAGCCAAGAGACACTTATAATGGAATGTGAGAGCTTTGAAAATATTGTTGAGTTTCTTAAAAACACGCTACCTGATATGAAT
ACCTCTGAAATGGAAAAAATTATTACCCAGGTTTTTGAGATGGATATTTCTAAGCAGTTGCATGCCTATGAGGTGGAATATCATGTGCTA
CAGGATGAGCTTCAGGAATCTTCATATTCCTGTGAGGATAGTGAAACTTTGGAGAAGCTGGAGAGGGCCAATAGCCAACTGAAAAGACAA
AACATGGACCTCCTAGAAAAATTACAGGTAGCTCATACTAAAATCCAGGCCTTGGAATCAAACCTGGAAAATCTTTTGACGAGAGAGACC
AAAATGAAGTCTTTAATCCGGACCCTGGAACAAGAAAAAATGGCTTATCAAAAGACAGTGGAGCAACTCCGGAAGCTGCTGCCCGCGGAT
GCTCTAGTCAATTGTGACCTGTTGCTGAGAGACCTAAACTGCAACCCTAACAACAAAGCCAAGATAGGAAATAAGCCATAATTGAAGAGG
CACGGCCTCAGCAGAAAGTGCTCCTTAGAATACTACAGAGAGGAAGAGCCTGCATGTCGCTGGCCCAAGGCTGGACCCTGAAGCTGATGG
AACCACCTAATACTGGTGCTGAGCGCCTAGTCACAGCAGGTGGACCTCGTGCTCATCAGAGCATGCCAATCCTAAGCCATTGGACATATG
TAGACTGGTTTTTGTTGTTGCTATGTACATATAAATATATATATAAAATGAACATAGTTCATGCTTTCAGATAAAATGAGTAGATGTATA
TTTAGATTAATTTTTTTAGTCAGAACTTCATGAAATCCACACCAAAGGAAAGGTAAACTGAAATTTCCCTTGGACATATGTGAAATCTTT
TTGTCTTTATAGTGAAACAAAGCCAGAGCATCTTTGTATATTGCAATATACTTGAAAAAAATGAATGTATTTTTTTCTCCAAAGAACAGC
ATGTTTCACTCAATGGTGAAAAGGTGGAAACATTTATGTAACTTTATGTGTATCTGTCTTGATATCTACTGACATTGTCTATATGAGGAA
AATGATTACTGGTCATGCTCCTGTGAGTTTTTTGGGAAGGTAGGGTCATTTCTCCCTGCCTGCTTTGTGCCAACTAGCATGTTGCATCTA
CATGCATTATGAGTCTGGTTAGGCATTACTTTAAACATACATAAAGAGACAGTAGGACATTGTGGCTGAGTCTACCCAGCTCAAGGTAAA
GGAGAATGTTGCTAATTTTTTAGCAAACTAGACCAGCATTATTACTCAAACTAAAAATATCACACCTGAAAAATTTAATTTAGGACCTAA
AATGTCTAGATTAGCTTTCTGCTTTTTTTATTTGAATAACTCATTCAGTTGTGAATGAATTCCTCTTTATTTGGTGCCACAGTCACCAAA
TGACAAGGATTTGCCACTTTCCCACCAAATTGTGAGTGCTTGTAATTTAGGTCTCTCTACCTTAAATTCAGTATAAGGAAACGTAATTAT
GATTGATTTTTTCCAAAGATGACAAGCTGTGTTGAAATACATTTTTTCTTTTGACCAATTGACAGAATCTAATAAGCTTTAATAATCTTC
CCCTTTTATGTGAAAAGTTTTGAGAACTGTGAAATGTTTAGGAACAAACTGTTGAAATCCATTGGAAGGGAAAAAAGAAAGTGGTACCAG
TGTTACCAGCTCAACTAAAACCTGCAATTCTGCATTTCAACTCTTCACTTCCTCAGCCTACAAATAGCTCATTAGATGACATTCACGCAT
GCTGGGTATAGGCAAGGAAAGTAATTTTCAAAGTACATTTGCAGTTCTCTTTTTCAGAGATGATTCTATGATAGTGCCTCTGAAAGTTGA
TGCAGCATTTTTGCCTTTCCAAAAAGTATTTATCCTCACTGCTTTTTGCAGTACTTGTATTTTCACAGATGGATTATCTGGGGTAATTTT
CTTCAAAGGGAGTTTGTTATACACAGTGAAAATGTATTATAGAGTAGAATAGTAAAGCTCTAGGGGTTTCAGAAAGCTTTGATGAACAGA
TGACAAACATCTGAAACCCCCTCCGCACTGTTACCCAGTGTGTATATAATGACTTGTTATAGCTCAGTGTGCCCTTGAATCCATACAGTT
TCTTAAAAGACAATAAAATCTTATTAATAAAGTTAATGTAACTTCTAAGTTCTAGAAAATGCTGATTCTGTCTGCCCCATTCAATTGGGG
GCTACTAATTGATTTGTTGCTTGGATTTCCTGAGAATTTCTCTATTTGTAGGAGGGGTTTTTTCTTTTTACGGTCTGTTGATGACAATTA
CTTTATGGGTGTGATGCACCGATGGTAGCCAAGGAATCTGTTGGGGAAGTTCGGAAAGAAACCTTTTCTTTCTTTTATTCAGTTTAAAGT
AAACTTTATCCTGGATGTTTAGAATCAACATTAAGAGTTATATTATGGTGTTCAGAGATTAAGCTGACTTGGATACAATATTTTCTTTTG
AAAATGAATTTTCTTTTTCATTTGTGATTTTTAAAAAATGTTGCACCAGTTATGCTTCATGCATCGTTACATCTTCATCAGGTTAATGTA

>24993_24993_5_EDNRB-TBC1D4_EDNRB_chr13_78473994_ENST00000446573_TBC1D4_chr13_75936743_ENST00000377636_length(amino acids)=1546AA_BP=1
MKLRSGHRTPSGAGSSMQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKG
DRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLA
EDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRI
CLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRI
LKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKF
EVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSS
RVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNF
KDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLY
PPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNK
AKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKR
KLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSD
GEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEE
RKKSKELRSLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKS
RRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGIS
FVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVA
RVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYS
CEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLR

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>24993_24993_6_EDNRB-TBC1D4_EDNRB_chr13_78473994_ENST00000446573_TBC1D4_chr13_75936743_ENST00000431480_length(transcript)=6946nt_BP=1452nt
AAGAAAAACAGCTGAGAGGGCATCAGGAAGGAGTTTCGACCCGCGCTGGCGAGTCATGAGCGCCAAGTTTCCCACTGGCGCGCAAACTTG
AGTTACTTTTGAGCGTGGATACTGGCGAAGAGGCTGCGGGCGGTATTAGCGTTTGCAGCGACTTGGCTCGGGCAGCTGACCCAAGTGTCC
TGTCTTCCTTCCTCTGCTTGTCTCTAGGCTCTGAAACTGCGGAGCGGCCACCGGACGCCTTCTGGAGCAGGTAGCAGCATGCAGCCGCCT
CCAAGTCTGTGCGGACGCGCCCTGGTTGCGCTGGTTCTTGCCTGCGGCCTGTCGCGGATCTGGGGAGAGGAGAGAGGCTTCCCGCCTGAC
AGGGCCACTCCGCTTTTGCAAACCGCAGAGATAATGACGCCACCCACTAAGACCTTATGGCCCAAGGGTTCCAACGCCAGTCTGGCGCGG
TCGTTGGCACCTGCGGAGGTGCCTAAAGGAGACAGGACGGCAGGATCTCCGCCACGCACCATCTCCCCTCCCCCGTGCCAAGGACCCATC
GAGATCAAGGAGACTTTCAAATACATCAACACGGTTGTGTCCTGCCTTGTGTTCGTGCTGGGGATCATCGGGAACTCCACACTTCTGAGA
ATTATCTACAAGAACAAGTGCATGCGAAACGGTCCCAATATCTTGATCGCCAGCTTGGCTCTGGGAGACCTGCTGCACATCGTCATTGAC
ATCCCTATCAATGTCTACAAGCTGCTGGCAGAGGACTGGCCATTTGGAGCTGAGATGTGTAAGCTGGTGCCTTTCATACAGAAAGCCTCT
GTGGGAATCACTGTGCTGAGTCTATGTGCTCTGAGTATTGACAGATATCGAGCTGTTGCTTCTTGGAGTAGAATTAAAGGAATTGGGGTT
CCAAAATGGACAGCAGTAGAAATTGTTTTGATTTGGGTGGTCTCTGTGGTTCTGGCTGTCCCTGAAGCCATAGGTTTTGATATAATTACG
ATGGACTACAAAGGAAGTTATCTGCGAATCTGCTTGCTTCATCCCGTTCAGAAGACAGCTTTCATGCAGTTTTACAAGACAGCAAAAGAT
TGGTGGCTATTCAGTTTCTATTTCTGCTTGCCATTGGCCATCACTGCATTTTTTTATACACTAATGACCTGTGAAATGTTGAGAAAGAAA
AGTGGCATGCAGATTGCTTTAAATGATCACCTAAAGCAGAGACGGGAAGTGGCCAAAACCGTCTTTTGCCTGGTCCTTGTCTTTGCCCTC
TGCTGGCTTCCCCTTCACCTCAGCAGGATTCTGAAGCTCACTCTTTATAATCAGAATGATCCCAATAGATGTGAACTTTTGAGCTTTCTG
TTGGTATTGGACTATATTGGTATCAACATGGCTTCACTGAATTCCTGCATTAACCCAATTGCTCTGTATTTGGTGAGCAAAAGATTCAAA
AACTGCTTTAAGGTTCCTGATGTTATTAGCAGCATAAGGCAATTATCTAAAGCGGCCATGAAAGAGGATGCCAAACCCAGCAAAGATAAT
GAGGACGCCTTTTACAACTCTCAGAAGTTCGAAGTCCTGTACTGTGGAAAGGTGACCGTGACCCACAAGAAGGCCCCCTCAAGCCTCATC
GATGACTGCATGGAGAAGTTCAGCCTGCACGAACAGCAGCGCCTGAAGATCCAAGGGGAGCAGCGCGGTCCGGACCCAGGAGAGGACCTG
GCTGACTTGGAGGTGGTGGTGCCCGGGTCCCCCGGAGACTGCCTGCCGGAGGAGGCTGACGGCACCGACACCCACCTTGGCTTACCTGCC
GGGGCCAGCCAGCCTGCCCTGACCAGCTCTCGGGTCTGCTTCCCTGAGCGGATTTTGGAAGATTCTGGCTTTGATGAGCAGCAGGAGTTT
CGGTCTCGGTGCAGCAGTGTCACCGGCGTGCAACGGAGAGTTCACGAGGGCAGCCAGAAATCCCAGCCGCGACGGAGACACGCGAGCGCA
CCCAGTCACGTCCAGCCCTCGGACTCGGAGAAGAACAGGACCATGCTCTTCCAGGTTGGGCGATTTGAGATTAACCTTATCAGTCCAGAC
ACTAAATCAGTTGTGCTAGAAAAGAATTTTAAAGATATCTCCTCTTGTTCTCAGGGTATAAAGCATGTGGATCACTTTGGCTTTATCTGC
CGGGAGTCTCCAGAGCCTGGACTTAGCCAGTATATTTGTTATGTATTCCAGTGTGCCAGCGAATCTCTGGTTGATGAGGTAATGCTGACT
CTGAAACAGGCCTTCAGTACGGCGGCTGCCCTGCAGAGTGCCAAGACGCAGATTAAACTGTGTGAGGCCTGCCCGATGCACTCTTTGCAT
AAGCTCTGTGAAAGGATTGAAGGTCTCTACCCACCAAGAGCCAAGCTGGTGATACAGAGGCATCTCTCATCACTGACAGATAATGAGCAA
GCTGACATCTTTGAAAGAGTTCAGAAAATGAAGCCAGTCAGTGACCAGGAAGAAAATGAACTTGTGATTTTACACCTGAGGCAGCTGTGT
GAAGCCAAGCAGAAGACACACGTGCACATCGGGGAAGGCCCTTCTACTATTTCAAATAGTACAATCCCAGAAAATGCAACAAGCAGTGGA
AGGTTCAAACTTGACATTCTGAAAAATAAAGCTAAGAGATCCTTAACTAGCTCCCTGGAAAATATCTTCTCAAGGGGAGCTAACAGAATG
AGAGGTCGGCTTGGAAGTGTGGACAGTTTTGAACGGTCCAACAGTCTTGCTTCAGAGAAGGACTACTCACCAGGGGATTCTCCACCAGGG
ACACCGCCAGCGTCCCCACCGTCCTCAGCTTGGCAAACGTTTCCCGAAGAGGATTCCGACTCCCCGCAGTTTCGAAGACGGGCACACACG
TTCAGCCACCCACCTTCAAGCACAAAGAGAAAGCTGAATTTGCAGGATGGGAGGGCTCAGGGTGTGCGTTCCCCTCTGCTGAGGCAGAGC
TCCAGTGAACAGTGCAGCAATCTTTCGTCAGTTCGACGCATGTACAAGGAGAGTAATTCTTCCTCCAGTCTTCCAAGTCTTCACACTTCC
TTCTCTGCCCCTTCCTTCACTGCCCCCTCTTTCCTGAAAAGCTTTTACCAGAATTCAGGTAGACTGTCCCCACAGTATGAAAATGAAATC
AGTGATGGAGAAGGGAGAAAAAGGACCTCATCTACCTGCAGCAATGAGTCCCTAAGTGTGGGAGGAACCTCTGTCACTCCTCGCCGGATC
TCCTGGCGGCAGCGCATTTTCCTCAGGGTTGCTTCTCCCATGAACAAATCTCCCTCAGCAATGCAACAGCAAGATGGATTGGACAGGAAC
GAGCTGCTGCCACTGTCCCCCCTCTCTCCAACCATGGAGGAGGAACCGCTGGTTGTATTCCTGTCTGGGGAGGATGACCCAGAAAAGATT
GAAGAAAGAAAGAAATCAAAAGAACTGAGGAGCTTGTGGAGAAAAGCTATACACCAACAAATCTTGTTACTTCGAATGGAAAAAGAAAAC
CAGAAACTTGAAGCAAGCAGAGATGAACTCCAGTCCAGAAAAGTTAAATTAGACTATGAAGAAGTTGGTGCATGTCAGAAAGAGGTCTTA
ATAACTTGGGATAAGAAGTTGTTAAACTGCAGAGCTAAAATCAGATGTGATATGGAAGATATTCATACTCTTCTTAAAGAAGGAGTTCCC
AAAAGTCGACGAGGAGAAATTTGGCAGTTTCTGGCTTTACAGTACCGACTCAGACACAGATTGCCTAATAAACAACAGCCTCCTGACATA
TCCTATAAGGAACTTTTGAAGCAGCTCACTGCTCAGCAGCATGCGATTCTCGTGGATTTAGGAAGGACGTTTCCTACTCACCCTTACTTT
TCAGTACAGCTTGGGCCAGGACAGCTGTCACTGTTTAACCTCCTGAAAGCCTATTCTTTGCTGGACAAAGAAGTGGGATACTGTCAGGGG
ATCAGCTTTGTGGCTGGAGTCCTGCTTCTGCACATGAGTGAAGAGCAAGCCTTTGAAATGCTGAAATTCCTCATGTATGACCTCGGCTTC
CGCAAGCAGTACAGACCTGACATGATGTCGCTGCAGATTCAAATGTACCAGCTGTCCAGGCTCCTTCATGACTATCACAGAGATCTCTAC
AATCACCTTGAAGAAAATGAAATCAGCCCCAGTCTTTATGCTGCCCCCTGGTTCCTCACATTGTTTGCCTCTCAGTTTTCATTAGGATTT
GTAGCCAGAGTTTTTGATATTATTTTTCTTCAGGGAACTGAAGTTATATTCAAGGTTGCACTCAGCCTACTGAGCAGCCAAGAGACACTT
ATAATGGAATGTGAGAGCTTTGAAAATATTGTTGAGTTTCTTAAAAACACGCTACCTGATATGAATACCTCTGAAATGGAAAAAATTATT
ACCCAGGTTTTTGAGATGGATATTTCTAAGCAGTTGCATGCCTATGAGGTGGAATATCATGTGCTACAGGATGAGCTTCAGGAATCTTCA
TATTCCTGTGAGGATAGTGAAACTTTGGAGAAGCTGGAGAGGGCCAATAGCCAACTGAAAAGACAAAACATGGACCTCCTAGAAAAATTA
CAGGTAGCTCATACTAAAATCCAGGCCTTGGAATCAAACCTGGAAAATCTTTTGACGAGAGAGACCAAAATGAAGTCTTTAATCCGGACC
CTGGAACAAGAAAAAATGGCTTATCAAAAGACAGTGGAGCAACTCCGGAAGCTGCTGCCCGCGGATGCTCTAGTCAATTGTGACCTGTTG
CTGAGAGACCTAAACTGCAACCCTAACAACAAAGCCAAGATAGGAAATAAGCCATAATTGAAGAGGCACGGCCTCAGCAGAAAGTGCTCC
TTAGAATACTACAGAGAGGAAGAGCCTGCATGTCGCTGGCCCAAGGCTGGACCCTGAAGCTGATGGAACCACCTAATACTGGTGCTGAGC
GCCTAGTCACAGCAGGTGGACCTCGTGCTCATCAGAGCATGCCAATCCTAAGCCATTGGACATATGTAGACTGGTTTTTGTTGTTGCTAT
GTACATATAAATATATATATAAAATGAACATAGTTCATGCTTTCAGATAAAATGAGTAGATGTATATTTAGATTAATTTTTTTAGTCAGA
ACTTCATGAAATCCACACCAAAGGAAAGGTAAACTGAAATTTCCCTTGGACATATGTGAAATCTTTTTGTCTTTATAGTGAAACAAAGCC
AGAGCATCTTTGTATATTGCAATATACTTGAAAAAAATGAATGTATTTTTTTCTCCAAAGAACAGCATGTTTCACTCAATGGTGAAAAGG
TGGAAACATTTATGTAACTTTATGTGTATCTGTCTTGATATCTACTGACATTGTCTATATGAGGAAAATGATTACTGGTCATGCTCCTGT
GAGTTTTTTGGGAAGGTAGGGTCATTTCTCCCTGCCTGCTTTGTGCCAACTAGCATGTTGCATCTACATGCATTATGAGTCTGGTTAGGC
ATTACTTTAAACATACATAAAGAGACAGTAGGACATTGTGGCTGAGTCTACCCAGCTCAAGGTAAAGGAGAATGTTGCTAATTTTTTAGC
AAACTAGACCAGCATTATTACTCAAACTAAAAATATCACACCTGAAAAATTTAATTTAGGACCTAAAATGTCTAGATTAGCTTTCTGCTT
TTTTTATTTGAATAACTCATTCAGTTGTGAATGAATTCCTCTTTATTTGGTGCCACAGTCACCAAATGACAAGGATTTGCCACTTTCCCA
CCAAATTGTGAGTGCTTGTAATTTAGGTCTCTCTACCTTAAATTCAGTATAAGGAAACGTAATTATGATTGATTTTTTCCAAAGATGACA
AGCTGTGTTGAAATACATTTTTTCTTTTGACCAATTGACAGAATCTAATAAGCTTTAATAATCTTCCCCTTTTATGTGAAAAGTTTTGAG
AACTGTGAAATGTTTAGGAACAAACTGTTGAAATCCATTGGAAGGGAAAAAAGAAAGTGGTACCAGTGTTACCAGCTCAACTAAAACCTG
CAATTCTGCATTTCAACTCTTCACTTCCTCAGCCTACAAATAGCTCATTAGATGACATTCACGCATGCTGGGTATAGGCAAGGAAAGTAA
TTTTCAAAGTACATTTGCAGTTCTCTTTTTCAGAGATGATTCTATGATAGTGCCTCTGAAAGTTGATGCAGCATTTTTGCCTTTCCAAAA
AGTATTTATCCTCACTGCTTTTTGCAGTACTTGTATTTTCACAGATGGATTATCTGGGGTAATTTTCTTCAAAGGGAGTTTGTTATACAC
AGTGAAAATGTATTATAGAGTAGAATAGTAAAGCTCTAGGGGTTTCAGAAAGCTTTGATGAACAGATGACAAACATCTGAAACCCCCTCC
GCACTGTTACCCAGTGTGTATATAATGACTTGTTATAGCTCAGTGTGCCCTTGAATCCATACAGTTTCTTAAAAGACAATAAAATCTTAT
TAATAAAGTTAATGTAACTTCTAAGTTCTAGAAAATGCTGATTCTGTCTGCCCCATTCAATTGGGGGCTACTAATTGATTTGTTGCTTGG
ATTTCCTGAGAATTTCTCTATTTGTAGGAGGGGTTTTTTCTTTTTACGGTCTGTTGATGACAATTACTTTATGGGTGTGATGCACCGATG
GTAGCCAAGGAATCTGTTGGGGAAGTTCGGAAAGAAACCTTTTCTTTCTTTTATTCAGTTTAAAGTAAACTTTATCCTGGATGTTTAGAA
TCAACATTAAGAGTTATATTATGGTGTTCAGAGATTAAGCTGACTTGGATACAATATTTTCTTTTGAAAATGAATTTTCTTTTTCATTTG
TGATTTTTAAAAAATGTTGCACCAGTTATGCTTCATGCATCGTTACATCTTCATCAGGTTAATGTAATGTCTAGTTCCTTTGCAATAAAT

>24993_24993_6_EDNRB-TBC1D4_EDNRB_chr13_78473994_ENST00000446573_TBC1D4_chr13_75936743_ENST00000431480_length(amino acids)=1538AA_BP=1
MKLRSGHRTPSGAGSSMQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKG
DRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLA
EDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRI
CLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRI
LKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKF
EVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSS
RVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNF
KDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLY
PPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNK
AKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKR
KLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEISDGEGRKRTS
STCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELR
SLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQF
LALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLL
HMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFL
QGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLE
KLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNCNPNN

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Fusion Gene PPI Analysis for EDNRB-TBC1D4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EDNRB-TBC1D4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EDNRB-TBC1D4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEDNRBC1848519WAARDENBURG SYNDROME, TYPE 4A11CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneEDNRBC1838564HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 27GENOMICS_ENGLAND;UNIPROT
HgeneEDNRBC1838099ABCD syndrome3CTD_human;GENOMICS_ENGLAND
HgeneEDNRBC0085758Aganglionosis, Colonic2CTD_human;GENOMICS_ENGLAND
HgeneEDNRBC0006142Malignant neoplasm of breast1CTD_human
HgeneEDNRBC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneEDNRBC0018801Heart failure1CTD_human
HgeneEDNRBC0018802Congestive heart failure1CTD_human
HgeneEDNRBC0019284Diaphragmatic Hernia1CTD_human
HgeneEDNRBC0019569Hirschsprung Disease1CTD_human
HgeneEDNRBC0020542Pulmonary Hypertension1CTD_human
HgeneEDNRBC0023212Left-Sided Heart Failure1CTD_human
HgeneEDNRBC0027626Neoplasm Invasiveness1CTD_human
HgeneEDNRBC0027720Nephrosis1CTD_human
HgeneEDNRBC0038525Subarachnoid Hemorrhage1CTD_human
HgeneEDNRBC0235527Heart Failure, Right-Sided1CTD_human
HgeneEDNRBC0270192Perinatal Subarachnoid Hemorrhage1CTD_human
HgeneEDNRBC0472383Subarachnoid Hemorrhage, Spontaneous1CTD_human
HgeneEDNRBC0678222Breast Carcinoma1CTD_human
HgeneEDNRBC0751530Subarachnoid Hemorrhage, Aneurysmal1CTD_human
HgeneEDNRBC0795688Subarachnoid Hemorrhage, Intracranial1CTD_human
HgeneEDNRBC1257840Aganglionosis, Rectosigmoid Colon1CTD_human
HgeneEDNRBC1257931Mammary Neoplasms, Human1CTD_human
HgeneEDNRBC1458155Mammary Neoplasms1CTD_human
HgeneEDNRBC1959583Myocardial Failure1CTD_human
HgeneEDNRBC1961112Heart Decompensation1CTD_human
HgeneEDNRBC2700265Waardenburg Syndrome Type 21ORPHANET
HgeneEDNRBC3266898Waardenburg Syndrome1GENOMICS_ENGLAND;ORPHANET
HgeneEDNRBC3495676Anorectal Malformations1GENOMICS_ENGLAND
HgeneEDNRBC3661523Congenital Intestinal Aganglionosis1CTD_human
HgeneEDNRBC4704874Mammary Carcinoma, Human1CTD_human
TgeneC3495676Anorectal Malformations1GENOMICS_ENGLAND