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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:EFNA1-ADAM15 (FusionGDB2 ID:HG1942TG8751) |
Fusion Gene Summary for EFNA1-ADAM15 |
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Fusion gene information | Fusion gene name: EFNA1-ADAM15 | Fusion gene ID: hg1942tg8751 | Hgene | Tgene | Gene symbol | EFNA1 | ADAM15 | Gene ID | 1942 | 8751 |
Gene name | ephrin A1 | ADAM metallopeptidase domain 15 | |
Synonyms | B61|ECKLG|EFL1|EPLG1|GMAN|LERK-1|LERK1|TNFAIP4 | MDC15 | |
Cytomap | ('EFNA1')('ADAM15') 1q22 | 1q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ephrin-A1TNF alpha-induced protein 4eph-related receptor tyrosine kinase ligand 1epididymis secretory sperm binding proteingastric cancer metastasis associated long noncoding RNAimmediate early response protein B61ligand of eph-related kinase 1tumo | disintegrin and metalloproteinase domain-containing protein 15MDC-15a disintegrin and metalloproteinase domain 15 (metargidin)metalloprotease RGD disintegrin proteinmetalloproteinase-like, disintegrin-like, and cysteine-rich protein 15 | |
Modification date | 20200313 | 20200320 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000469878, ENST00000368406, ENST00000368407, | ||
Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 3 X 3 X 3=27 |
# samples | 8 | 3 | |
** MAII score | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: EFNA1 [Title/Abstract] AND ADAM15 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | EFNA1(155104110)-ADAM15(155034936), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | EFNA1-ADAM15 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EFNA1 | GO:0016477 | cell migration | 10655584 |
Hgene | EFNA1 | GO:0033628 | regulation of cell adhesion mediated by integrin | 10655584 |
Hgene | EFNA1 | GO:0034446 | substrate adhesion-dependent cell spreading | 10655584 |
Hgene | EFNA1 | GO:0048013 | ephrin receptor signaling pathway | 10655584 |
Hgene | EFNA1 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 10655584 |
Hgene | EFNA1 | GO:1902004 | positive regulation of amyloid-beta formation | 24217950 |
Tgene | ADAM15 | GO:0002418 | immune response to tumor cell | 22505472 |
Tgene | ADAM15 | GO:0006915 | apoptotic process | 22505472 |
Tgene | ADAM15 | GO:0045087 | innate immune response | 22505472 |
Tgene | ADAM15 | GO:1904628 | cellular response to phorbol 13-acetate 12-myristate | 22505472 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LIHC | TCGA-ZS-A9CF-01A | EFNA1 | chr1 | 155104110 | - | ADAM15 | chr1 | 155034936 | + |
ChimerDB4 | LIHC | TCGA-ZS-A9CF-01A | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
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Fusion Gene ORF analysis for EFNA1-ADAM15 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000469878 | ENST00000449910 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
3UTR-3UTR | ENST00000469878 | ENST00000271836 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
3UTR-3UTR | ENST00000469878 | ENST00000355956 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
3UTR-3UTR | ENST00000469878 | ENST00000356955 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
3UTR-3UTR | ENST00000469878 | ENST00000359280 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
3UTR-3UTR | ENST00000469878 | ENST00000360674 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
3UTR-3UTR | ENST00000469878 | ENST00000368410 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
3UTR-3UTR | ENST00000469878 | ENST00000368412 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
3UTR-3UTR | ENST00000469878 | ENST00000368413 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
3UTR-3UTR | ENST00000469878 | ENST00000472434 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
3UTR-3UTR | ENST00000469878 | ENST00000531455 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
3UTR-intron | ENST00000469878 | ENST00000447332 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368406 | ENST00000271836 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368406 | ENST00000355956 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368406 | ENST00000356955 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368406 | ENST00000359280 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368406 | ENST00000360674 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368406 | ENST00000368410 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368406 | ENST00000368412 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368406 | ENST00000368413 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368406 | ENST00000472434 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368406 | ENST00000531455 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368407 | ENST00000271836 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368407 | ENST00000355956 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368407 | ENST00000356955 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368407 | ENST00000359280 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368407 | ENST00000360674 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368407 | ENST00000368410 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368407 | ENST00000368412 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368407 | ENST00000368413 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368407 | ENST00000472434 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-3UTR | ENST00000368407 | ENST00000531455 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-intron | ENST00000368406 | ENST00000447332 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
5CDS-intron | ENST00000368407 | ENST00000447332 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
Frame-shift | ENST00000368406 | ENST00000449910 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
Frame-shift | ENST00000368407 | ENST00000449910 | EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034936 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for EFNA1-ADAM15 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034935 | + | 0.001450263 | 0.99854976 |
EFNA1 | chr1 | 155104110 | + | ADAM15 | chr1 | 155034935 | + | 0.001450263 | 0.99854976 |
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Fusion Protein Features for EFNA1-ADAM15 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:155104110/:155034936) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for EFNA1-ADAM15 |
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Fusion Gene PPI Analysis for EFNA1-ADAM15 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for EFNA1-ADAM15 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for EFNA1-ADAM15 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EFNA1 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
Hgene | EFNA1 | C0678222 | Breast Carcinoma | 1 | CTD_human |
Hgene | EFNA1 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
Hgene | EFNA1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | EFNA1 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |