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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARID2-ZNF641 (FusionGDB2 ID:HG196528TG121274)

Fusion Gene Summary for ARID2-ZNF641

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID2-ZNF641
Fusion gene ID: hg196528tg121274
HgeneTgene
Gene symbol

ARID2

ZNF641

Gene ID

196528

121274

Gene nameAT-rich interaction domain 2zinc finger protein 641
SynonymsBAF200|CSS6|p200-
Cytomap('ARID2')('ZNF641')

12q12

12q13.11

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 2ARID domain-containing protein 2AT rich interactive domain 2 (ARID, RFX-like)BRG1-associated factor 200zinc finger protein with activation potentialzipzap/p200zinc finger protein 641
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000334344, ENST00000422737, 
ENST00000444670, ENST00000457135, 
ENST00000479608, 
Fusion gene scores* DoF score17 X 9 X 12=18361 X 1 X 1=1
# samples 171
** MAII scorelog2(17/1836*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ARID2 [Title/Abstract] AND ZNF641 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARID2(46125097)-ZNF641(48741898), # samples:3
Anticipated loss of major functional domain due to fusion event.ARID2-ZNF641 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID2-ZNF641 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID2-ZNF641 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID2-ZNF641 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARID2

GO:0006337

nucleosome disassembly

8895581

HgeneARID2

GO:0008285

negative regulation of cell proliferation

26169693

HgeneARID2

GO:0030336

negative regulation of cell migration

26169693


check buttonFusion gene breakpoints across ARID2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZNF641 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A1AV-01AARID2chr12

46125097

-ZNF641chr12

48741898

-
ChimerDB4BRCATCGA-AR-A1AV-01AARID2chr12

46125097

+ZNF641chr12

48741898

-


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Fusion Gene ORF analysis for ARID2-ZNF641

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000334344ENST00000448928ARID2chr12

46125097

+ZNF641chr12

48741898

-
5CDS-5UTRENST00000334344ENST00000547026ARID2chr12

46125097

+ZNF641chr12

48741898

-
5UTR-3CDSENST00000422737ENST00000301042ARID2chr12

46125097

+ZNF641chr12

48741898

-
5UTR-3CDSENST00000422737ENST00000544117ARID2chr12

46125097

+ZNF641chr12

48741898

-
5UTR-5UTRENST00000422737ENST00000448928ARID2chr12

46125097

+ZNF641chr12

48741898

-
5UTR-5UTRENST00000422737ENST00000547026ARID2chr12

46125097

+ZNF641chr12

48741898

-
In-frameENST00000334344ENST00000301042ARID2chr12

46125097

+ZNF641chr12

48741898

-
In-frameENST00000334344ENST00000544117ARID2chr12

46125097

+ZNF641chr12

48741898

-
intron-3CDSENST00000444670ENST00000301042ARID2chr12

46125097

+ZNF641chr12

48741898

-
intron-3CDSENST00000444670ENST00000544117ARID2chr12

46125097

+ZNF641chr12

48741898

-
intron-3CDSENST00000457135ENST00000301042ARID2chr12

46125097

+ZNF641chr12

48741898

-
intron-3CDSENST00000457135ENST00000544117ARID2chr12

46125097

+ZNF641chr12

48741898

-
intron-3CDSENST00000479608ENST00000301042ARID2chr12

46125097

+ZNF641chr12

48741898

-
intron-3CDSENST00000479608ENST00000544117ARID2chr12

46125097

+ZNF641chr12

48741898

-
intron-5UTRENST00000444670ENST00000448928ARID2chr12

46125097

+ZNF641chr12

48741898

-
intron-5UTRENST00000444670ENST00000547026ARID2chr12

46125097

+ZNF641chr12

48741898

-
intron-5UTRENST00000457135ENST00000448928ARID2chr12

46125097

+ZNF641chr12

48741898

-
intron-5UTRENST00000457135ENST00000547026ARID2chr12

46125097

+ZNF641chr12

48741898

-
intron-5UTRENST00000479608ENST00000448928ARID2chr12

46125097

+ZNF641chr12

48741898

-
intron-5UTRENST00000479608ENST00000547026ARID2chr12

46125097

+ZNF641chr12

48741898

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000334344ARID2chr1246125097+ENST00000301042ZNF641chr1248741898-47214561391755538
ENST00000334344ARID2chr1246125097+ENST00000544117ZNF641chr1248741898-46024561391755538

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334344ENST00000301042ARID2chr1246125097+ZNF641chr1248741898-0.0135381530.9864618
ENST00000334344ENST00000544117ARID2chr1246125097+ZNF641chr1248741898-0.0148794880.9851206

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Fusion Genomic Features for ARID2-ZNF641


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARID2-ZNF641


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:46125097/chr12:48741898)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF641chr12:46125097chr12:48741898ENST0000030104217109_1815439.0DomainKRAB
TgeneZNF641chr12:46125097chr12:48741898ENST0000044892805109_1810416.0DomainKRAB
TgeneZNF641chr12:46125097chr12:48741898ENST0000054411706109_1815439.0DomainKRAB
TgeneZNF641chr12:46125097chr12:48741898ENST0000054702606109_1810425.0DomainKRAB
TgeneZNF641chr12:46125097chr12:48741898ENST0000030104217171_2655439.0RegionNote=Transactivation
TgeneZNF641chr12:46125097chr12:48741898ENST0000044892805171_2650416.0RegionNote=Transactivation
TgeneZNF641chr12:46125097chr12:48741898ENST0000054411706171_2655439.0RegionNote=Transactivation
TgeneZNF641chr12:46125097chr12:48741898ENST0000054702606171_2650425.0RegionNote=Transactivation
TgeneZNF641chr12:46125097chr12:48741898ENST0000030104217264_2865439.0Zinc fingerC2H2-type 1
TgeneZNF641chr12:46125097chr12:48741898ENST0000030104217292_3145439.0Zinc fingerC2H2-type 2
TgeneZNF641chr12:46125097chr12:48741898ENST0000030104217320_3425439.0Zinc fingerC2H2-type 3
TgeneZNF641chr12:46125097chr12:48741898ENST0000030104217372_3945439.0Zinc fingerC2H2-type 4
TgeneZNF641chr12:46125097chr12:48741898ENST0000030104217400_4225439.0Zinc fingerC2H2-type 5
TgeneZNF641chr12:46125097chr12:48741898ENST0000044892805264_2860416.0Zinc fingerC2H2-type 1
TgeneZNF641chr12:46125097chr12:48741898ENST0000044892805292_3140416.0Zinc fingerC2H2-type 2
TgeneZNF641chr12:46125097chr12:48741898ENST0000044892805320_3420416.0Zinc fingerC2H2-type 3
TgeneZNF641chr12:46125097chr12:48741898ENST0000044892805372_3940416.0Zinc fingerC2H2-type 4
TgeneZNF641chr12:46125097chr12:48741898ENST0000044892805400_4220416.0Zinc fingerC2H2-type 5
TgeneZNF641chr12:46125097chr12:48741898ENST0000054411706264_2865439.0Zinc fingerC2H2-type 1
TgeneZNF641chr12:46125097chr12:48741898ENST0000054411706292_3145439.0Zinc fingerC2H2-type 2
TgeneZNF641chr12:46125097chr12:48741898ENST0000054411706320_3425439.0Zinc fingerC2H2-type 3
TgeneZNF641chr12:46125097chr12:48741898ENST0000054411706372_3945439.0Zinc fingerC2H2-type 4
TgeneZNF641chr12:46125097chr12:48741898ENST0000054411706400_4225439.0Zinc fingerC2H2-type 5
TgeneZNF641chr12:46125097chr12:48741898ENST0000054702606264_2860425.0Zinc fingerC2H2-type 1
TgeneZNF641chr12:46125097chr12:48741898ENST0000054702606292_3140425.0Zinc fingerC2H2-type 2
TgeneZNF641chr12:46125097chr12:48741898ENST0000054702606320_3420425.0Zinc fingerC2H2-type 3
TgeneZNF641chr12:46125097chr12:48741898ENST0000054702606372_3940425.0Zinc fingerC2H2-type 4
TgeneZNF641chr12:46125097chr12:48741898ENST0000054702606400_4220425.0Zinc fingerC2H2-type 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID2chr12:46125097chr12:48741898ENST00000334344+321793_1128941836.0Compositional biasNote=Gln-rich
HgeneARID2chr12:46125097chr12:48741898ENST00000334344+321524_603941836.0DNA bindingRFX-type winged-helix
HgeneARID2chr12:46125097chr12:48741898ENST00000334344+32113_105941836.0DomainARID
HgeneARID2chr12:46125097chr12:48741898ENST00000334344+321313_317941836.0MotifNote=LXXLL
HgeneARID2chr12:46125097chr12:48741898ENST00000334344+3211632_1657941836.0Zinc fingerNote=C2H2-type


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Fusion Gene Sequence for ARID2-ZNF641


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6447_6447_1_ARID2-ZNF641_ARID2_chr12_46125097_ENST00000334344_ZNF641_chr12_48741898_ENST00000301042_length(transcript)=4721nt_BP=456nt
GCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCACCGCCGGCCCATGACTGAGCCCCGCCGCCGCCGGCCGAGGAATGGGCTCCG
GGCTCTGGTAGGAAGCGCTGGGAGCGGGGGGCGCTTTTAAAACACCGATCTGGGTTTTTTAAAAACCTCCTTTGAAAAAATAATGGCAAA
CTCGACGGGGAAGGCGCCTCCGGACGAGCGGAGAAAGGGACTCGCTTTCCTGGACGAGCTGCGGCAGTTCCACCACAGCAGAGGGTCGCC
TTTTAAAAAAATCCCTGCGGTGGGTGGGAAGGAGCTGGATCTTCACGGTCTCTACACCAGAGTCACTACTTTAGGCGGATTCGCGAAGGT
TTCTGAGAAGAATCAGTGGGGAGAAATTGTTGAAGAGTTCAACTTTCCCAGAAGTTGTTCTAACGCTGCCTTTGCTTTAAAACAGTATTA
CTTGCGGTCACAATTTGGGTCTGCAGCAGAAATGCTTTCAGAACAGACAGCAGCGCTGGGGACAGGATGGGAATCAATGAATGTACAGCT
GGATGGAGCAGAGCCCCAGGTGGAAAGGGGAAGCCAGGAAGAGCGGCCATGGAGAACAGTACCAGGACCTCTGGAGCACCTGTGCTGTGA
CCTTGAAGAGGAGCCACAGTCCCTTCAGGAGAAGGCTCAGTCTGCTCCCTGGGTTCCTGCAATTCCCCAGGAGGGGAACACTGGAGACTG
GGAGATGGCAGCTGCACTTCTTGCGGCTGGATCACAGGGCCTGGTAACCATCAAGGATGTGTCACTGTGCTTCTCTCAGGAGGAGTGGCG
GAGCCTGGACCCCTCTCAGACAGACTTTTATGGAGAATATGTCATGCAGGAAAACTGTGGGATAGTAGTCTCTCTGAGATTTCCAATTCC
CAAACTGGACATGCTTTCTCAACTAGAAGGAGGAGAAGAACAATGGGTCCCTGACCCCCAGGACTTAGAGGAGAGGGACATTCTGAGGGT
CACATATACAGGAGATGGAAGTGAACATGAGGGGGATACCCCTGAACTAGAAGCAGAACCTCCCAGAATGTTATCCAGCGTGTCTGAAGA
TACTGTTCTCTGGAACCCGGAGCATGATGAGAGCTGGGATTCCATGCCCAGCAGCTCCAGAGGAATGCTCCTGGGGCCCCCTTTTCTTCA
GGAAGATAGTTTCTCAAACCTGCTGTGTAGCACAGAGATGGATTCCCTGTTAAGACCCCACACATGCCCCCAGTGTGGGAAACAGTTTGT
ATGGGGTTCCCACCTTGCCAGGCATCAACAAACACACACTGGGGAGAGACCCTACAGCTGCCTCAAGTGTGAGAAGACCTTTGGGCGAAG
ACATCACCTCATCAGGCACCAGAAAACCCACCTACATGACAAGACCAGCAGGTGCTCTGAGTGTGGTAAGAATTTCCGATGCAACTCCCA
TCTGGCCAGCCACCAGAGAGTGCATGCAGAAGGCAAATCCTGCAAAGGCCAAGAGGTTGGAGAGAGCCCTGGCACAAGGAAACGGCAGCG
TGCCCCACCAGTGCCAAAGTGTCACGTGTGCACTGAATGTGGGAAGAGCTTTGGCCGAAGGCACCACCTTGTGAGACACTGGCTGACCCA
CACTGGGGAGAAGCCCTTCCAGTGCCCTCGCTGTGAGAAGAGCTTTGGCCGAAAACATCACCTGGACAGGCACCTGCTCACCCACCAGGG
ACAAAGTCCCCGGAACAGCTGGGACAGAGGAACATCTGTCTTTTGAAATCTGTTTCCACTACAGCTATGGTCAAGTCTATCAGCCGGTGC
TACCAGGAGTCACTGCCAGGGCTGCCGTTCTCCTGAACCCCAGTGGCCAGAATCATAAGCCCTGACCCCATCCCTAGAAAGATGAGGTCC
CAGCAATGGCCAGAGCATTTCTCACCAGTTCTGTGAGATAGCACATAAAAATAGAGTTCTTTGGGCAAAACTTTTGGGAAGCAATGCATC
CTACATGGGCTGATATTCAGCCTGAGCTGTTCTCAAGAGGAGAGTGGTACTGGCAGTTTATGGCTGAAATCCATTCTGATTGGTTGGAGT
CTATGCTATACCAGTTGTTAAACATTTTGAGTATCACTCTTGCATACTGTTACTATTATATTTTCTCTATATATAGACAGAAAGGCCATT
TTAGAATATTAAAGGCTCTGAAAATTTCTGCAGTAGACCCAACTGAAGGTTCTATTAAGGCAGTGTTTCCTAAATGTATTTGACCTCAGT
ATCCTTTCTATTTACATCCCACAGAACTGGTGACTATGAAACACTCTGGTGAACACTGGGTTAGAGAGTAACAAGGAAACAAGAGATAGT
GATCAGGCATCCAGAGCCCCCTTTTTTATCCATATGAAAGCCAGGGGGGCCAGACCTTGTTCATGTGTGGGTCTGTCTTCCTTATGCCAA
TCAGCAGTATATACATCACCTCTCACCCTCACCTGCTGAAAAAATAACCTTTTTACCCATTATTCCTACTCCCTTCATCCTGCACATACA
TATATCCAGCTGAGAGATCACACTACAAGGCTAAGAGATGATCTAATACCCCCAAATAGCCCTGGCCCACACAGAAAAACAGAAAAACAA
AAAAAACTTTATCCCCTTGAACAGTCCCCTCTCTCCTCTTGACTGTCTTTATGTGTCTGTGTATTTGTGTGCAGGGTCTTTGAAGACAGC
ATGCTATGTGCAAACTGTACAAGCTAGGTTTTCTAGGGGCTGTGTTCTGGGGATGAGGGTAGTGGGGATTATATGGGGTTTTTTCTTTGT
TTCAAGACAGGAAGCAGTCTGGTTAAGGGAGAACTAGTGGAAAGGGTTAAATGACAGGTTAAGTTGAGTACAAAGCTTTCCCAGTACTGC
TGAGATTAAGACAATTGTGGATGTGTATGTCTAGGTTTGAATCTCTGGGCTGCAGATTGCTTTTGCCCTGGCAGAGAAAGAGGAGTCTTT
GGGGAGGTGAGCTGTTTCTTGTTGATTTCAGGCAAGAGGCACATAGAAACTTTGTATTGAGTGGGGATTTTGTTTTAAGTGCTGGAAAAT
TAGGGCAGGAATTACGTGTTTGCAAGTTGTTGCCATCACTGGTTTGAATTTGACTGCCTCATCAAGGGGCAAGAGTTATTCTTGAAGATC
TCATTCTCCCAGAAACAGAACTTTAGGGAAAATGGCTGTGGCTTAGCTTTTCAGCTGCTGCAGGGTAATAAGCTTTCTGGTTGGTTTTCC
TTCCAATTCTGGAAAGGTGTCCACACTAAGACCCTTAACTCTAGGGCTTGCATAAGTATTCTAGCATCGTTAGCTAATGAGTTGGTCATT
GTTTCTCTTTATCAATAATTGTGTTAATACCAATCTTATAATTTAAAAATTATCTTGTATGTAAGAGCAGTTCGGGGTTAGGGAGGAAGA
GGAGCAAAGTGGGATATTTTCTCTTTAATGCTTAGATACTGTTTCTTCCCTAAGATGTGTTTCTCAACCACAATTGGTGGAATGAACCAG
AGAGGCAAGAGGAAGTGAATTGCACCAATTTAGTTTAGCGACTGTGCCTTTTGCAGGAAAAACTGGGTGAATCACAGCTCCTCAGAGTCC
TGGACTCAACTAGAATTGAAGATAGACTTATTTTGCTGACTGGGCTTCTTAGAGTTTATGTGACTTGAACAGCTTGGCCCCTGCCTCCCT
TCTGCTACTGTGAGCAGCCTTCCTTCTTCCTTCATTCTTCCTGGAATGCAGTTCTCTTGCTTATGATCCTATGAATAAGGCAAAATGGCT
GGTCTTTGTAAGGCAGGTCTTGCCCTAGCTTCTCAGAAACAGGAGCATTTTAGGATCAGTATTAGGAGATGCCCCAGGGAGTAAGAAAGT
ATTGGGTTCAGTGATAAATCTGGACTCTGACATTTCTTTTACTCTCCCTCTTTAATACTAAAAGCTCTGCATAAGCAATGGTTCAGAACC
TGTCTTGGGTACAGACCTGTTGAATCTGACAGAAACCAGAAACGCACTTTTGAGAAAAAGACATTTGTAATTCACTCAGTTTTCCATACA
CATTTAGCAGGTTCAAAGCCCATCTGTGGAATCCCTAAACTGCCTTCAAAGAAAGGGAGTTCCCCGATCTAAAATGGTCATTATATATTT
GTGTCAAGAATTAGAAGGCAAGGGTCACTAAATATTTTAAGGATTAAGGTACCAGAGGCATCAGTGGTATAAGGATGGAGTCTGGTCTTT
AATTACGACAAGGGTATTGCTTACATTCTACTCTCTGGTTTTCAAAAAGATCTGACATGCTGACAAATCCAGCTCCTCACAAATCTTGTT
TGAAGGACTTGTGGGAAGTGATATTCCTTACTATTAGATCACGCCCCTTATAACTACATGTTAACATCCAGCCTTTTATCTGTTTGAGTA
ATTGTAGGGATAGAAAGTGAAGCCCCCAGAGTTAGGTGCAAGTATAGCACCCAGCTGAAAGGCATCATGGAGTCTAAGGGCCTTCTACAG
AAGGGGCAATCCTTTGGGTTATTTCTGGTGTACCACTGTCTTCTCTACCTCGGTCCAACACCACCTCTCTTGGACAAAAAATAAAACAAG
CAACAGCCATCAGATGAGTGAATAGATTTGAATGATTTTTCCCACAGGGAATCAGCCTCAAATGTTCATGTTTCACCCCGTCCCCTTTAA

>6447_6447_1_ARID2-ZNF641_ARID2_chr12_46125097_ENST00000334344_ZNF641_chr12_48741898_ENST00000301042_length(amino acids)=538AA_BP=105
MGFLKTSFEKIMANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFP
RSCSNAAFALKQYYLRSQFGSAAEMLSEQTAALGTGWESMNVQLDGAEPQVERGSQEERPWRTVPGPLEHLCCDLEEEPQSLQEKAQSAP
WVPAIPQEGNTGDWEMAAALLAAGSQGLVTIKDVSLCFSQEEWRSLDPSQTDFYGEYVMQENCGIVVSLRFPIPKLDMLSQLEGGEEQWV
PDPQDLEERDILRVTYTGDGSEHEGDTPELEAEPPRMLSSVSEDTVLWNPEHDESWDSMPSSSRGMLLGPPFLQEDSFSNLLCSTEMDSL
LRPHTCPQCGKQFVWGSHLARHQQTHTGERPYSCLKCEKTFGRRHHLIRHQKTHLHDKTSRCSECGKNFRCNSHLASHQRVHAEGKSCKG

--------------------------------------------------------------
>6447_6447_2_ARID2-ZNF641_ARID2_chr12_46125097_ENST00000334344_ZNF641_chr12_48741898_ENST00000544117_length(transcript)=4602nt_BP=456nt
GCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCACCGCCGGCCCATGACTGAGCCCCGCCGCCGCCGGCCGAGGAATGGGCTCCG
GGCTCTGGTAGGAAGCGCTGGGAGCGGGGGGCGCTTTTAAAACACCGATCTGGGTTTTTTAAAAACCTCCTTTGAAAAAATAATGGCAAA
CTCGACGGGGAAGGCGCCTCCGGACGAGCGGAGAAAGGGACTCGCTTTCCTGGACGAGCTGCGGCAGTTCCACCACAGCAGAGGGTCGCC
TTTTAAAAAAATCCCTGCGGTGGGTGGGAAGGAGCTGGATCTTCACGGTCTCTACACCAGAGTCACTACTTTAGGCGGATTCGCGAAGGT
TTCTGAGAAGAATCAGTGGGGAGAAATTGTTGAAGAGTTCAACTTTCCCAGAAGTTGTTCTAACGCTGCCTTTGCTTTAAAACAGTATTA
CTTGCGGTCACAATTTGGGTCTGCAGCAGAAATGCTTTCAGAACAGACAGCAGCGCTGGGGACAGGATGGGAATCAATGAATGTACAGCT
GGATGGAGCAGAGCCCCAGGTGGAAAGGGGAAGCCAGGAAGAGCGGCCATGGAGAACAGTACCAGGACCTCTGGAGCACCTGTGCTGTGA
CCTTGAAGAGGAGCCACAGTCCCTTCAGGAGAAGGCTCAGTCTGCTCCCTGGGTTCCTGCAATTCCCCAGGAGGGGAACACTGGAGACTG
GGAGATGGCAGCTGCACTTCTTGCGGCTGGATCACAGGGCCTGGTAACCATCAAGGATGTGTCACTGTGCTTCTCTCAGGAGGAGTGGCG
GAGCCTGGACCCCTCTCAGACAGACTTTTATGGAGAATATGTCATGCAGGAAAACTGTGGGATAGTAGTCTCTCTGAGATTTCCAATTCC
CAAACTGGACATGCTTTCTCAACTAGAAGGAGGAGAAGAACAATGGGTCCCTGACCCCCAGGACTTAGAGGAGAGGGACATTCTGAGGGT
CACATATACAGGAGATGGAAGTGAACATGAGGGGGATACCCCTGAACTAGAAGCAGAACCTCCCAGAATGTTATCCAGCGTGTCTGAAGA
TACTGTTCTCTGGAACCCGGAGCATGATGAGAGCTGGGATTCCATGCCCAGCAGCTCCAGAGGAATGCTCCTGGGGCCCCCTTTTCTTCA
GGAAGATAGTTTCTCAAACCTGCTGTGTAGCACAGAGATGGATTCCCTGTTAAGACCCCACACATGCCCCCAGTGTGGGAAACAGTTTGT
ATGGGGTTCCCACCTTGCCAGGCATCAACAAACACACACTGGGGAGAGACCCTACAGCTGCCTCAAGTGTGAGAAGACCTTTGGGCGAAG
ACATCACCTCATCAGGCACCAGAAAACCCACCTACATGACAAGACCAGCAGGTGCTCTGAGTGTGGTAAGAATTTCCGATGCAACTCCCA
TCTGGCCAGCCACCAGAGAGTGCATGCAGAAGGCAAATCCTGCAAAGGCCAAGAGGTTGGAGAGAGCCCTGGCACAAGGAAACGGCAGCG
TGCCCCACCAGTGCCAAAGTGTCACGTGTGCACTGAATGTGGGAAGAGCTTTGGCCGAAGGCACCACCTTGTGAGACACTGGCTGACCCA
CACTGGGGAGAAGCCCTTCCAGTGCCCTCGCTGTGAGAAGAGCTTTGGCCGAAAACATCACCTGGACAGGCACCTGCTCACCCACCAGGG
ACAAAGTCCCCGGAACAGCTGGGACAGAGGAACATCTGTCTTTTGAAATCTGTTTCCACTACAGCTATGGTCAAGTCTATCAGCCGGTGC
TACCAGGAGTCACTGCCAGGGCTGCCGTTCTCCTGAACCCCAGTGGCCAGAATCATAAGCCCTGACCCCATCCCTAGAAAGATGAGGTCC
CAGCAATGGCCAGAGCATTTCTCACCAGTTCTGTGAGATAGCACATAAAAATAGAGTTCTTTGGGCAAAACTTTTGGGAAGCAATGCATC
CTACATGGGCTGATATTCAGCCTGAGCTGTTCTCAAGAGGAGAGTGGTACTGGCAGTTTATGGCTGAAATCCATTCTGATTGGTTGGAGT
CTATGCTATACCAGTTGTTAAACATTTTGAGTATCACTCTTGCATACTGTTACTATTATATTTTCTCTATATATAGACAGAAAGGCCATT
TTAGAATATTAAAGGCTCTGAAAATTTCTGCAGTAGACCCAACTGAAGGTTCTATTAAGGCAGTGTTTCCTAAATGTATTTGACCTCAGT
ATCCTTTCTATTTACATCCCACAGAACTGGTGACTATGAAACACTCTGGTGAACACTGGGTTAGAGAGTAACAAGGAAACAAGAGATAGT
GATCAGGCATCCAGAGCCCCCTTTTTTATCCATATGAAAGCCAGGGGGGCCAGACCTTGTTCATGTGTGGGTCTGTCTTCCTTATGCCAA
TCAGCAGTATATACATCACCTCTCACCCTCACCTGCTGAAAAAATAACCTTTTTACCCATTATTCCTACTCCCTTCATCCTGCACATACA
TATATCCAGCTGAGAGATCACACTACAAGGCTAAGAGATGATCTAATACCCCCAAATAGCCCTGGCCCACACAGAAAAACAGAAAAACAA
AAAAAACTTTATCCCCTTGAACAGTCCCCTCTCTCCTCTTGACTGTCTTTATGTGTCTGTGTATTTGTGTGCAGGGTCTTTGAAGACAGC
ATGCTATGTGCAAACTGTACAAGCTAGGTTTTCTAGGGGCTGTGTTCTGGGGATGAGGGTAGTGGGGATTATATGGGGTTTTTTCTTTGT
TTCAAGACAGGAAGCAGTCTGGTTAAGGGAGAACTAGTGGAAAGGGTTAAATGACAGGTTAAGTTGAGTACAAAGCTTTCCCAGTACTGC
TGAGATTAAGACAATTGTGGATGTGTATGTCTAGGTTTGAATCTCTGGGCTGCAGATTGCTTTTGCCCTGGCAGAGAAAGAGGAGTCTTT
GGGGAGGTGAGCTGTTTCTTGTTGATTTCAGGCAAGAGGCACATAGAAACTTTGTATTGAGTGGGGATTTTGTTTTAAGTGCTGGAAAAT
TAGGGCAGGAATTACGTGTTTGCAAGTTGTTGCCATCACTGGTTTGAATTTGACTGCCTCATCAAGGGGCAAGAGTTATTCTTGAAGATC
TCATTCTCCCAGAAACAGAACTTTAGGGAAAATGGCTGTGGCTTAGCTTTTCAGCTGCTGCAGGGTAATAAGCTTTCTGGTTGGTTTTCC
TTCCAATTCTGGAAAGGTGTCCACACTAAGACCCTTAACTCTAGGGCTTGCATAAGTATTCTAGCATCGTTAGCTAATGAGTTGGTCATT
GTTTCTCTTTATCAATAATTGTGTTAATACCAATCTTATAATTTAAAAATTATCTTGTATGTAAGAGCAGTTCGGGGTTAGGGAGGAAGA
GGAGCAAAGTGGGATATTTTCTCTTTAATGCTTAGATACTGTTTCTTCCCTAAGATGTGTTTCTCAACCACAATTGGTGGAATGAACCAG
AGAGGCAAGAGGAAGTGAATTGCACCAATTTAGTTTAGCGACTGTGCCTTTTGCAGGAAAAACTGGGTGAATCACAGCTCCTCAGAGTCC
TGGACTCAACTAGAATTGAAGATAGACTTATTTTGCTGACTGGGCTTCTTAGAGTTTATGTGACTTGAACAGCTTGGCCCCTGCCTCCCT
TCTGCTACTGTGAGCAGCCTTCCTTCTTCCTTCATTCTTCCTGGAATGCAGTTCTCTTGCTTATGATCCTATGAATAAGGCAAAATGGCT
GGTCTTTGTAAGGCAGGTCTTGCCCTAGCTTCTCAGAAACAGGAGCATTTTAGGATCAGTATTAGGAGATGCCCCAGGGAGTAAGAAAGT
ATTGGGTTCAGTGATAAATCTGGACTCTGACATTTCTTTTACTCTCCCTCTTTAATACTAAAAGCTCTGCATAAGCAATGGTTCAGAACC
TGTCTTGGGTACAGACCTGTTGAATCTGACAGAAACCAGAAACGCACTTTTGAGAAAAAGACATTTGTAATTCACTCAGTTTTCCATACA
CATTTAGCAGGTTCAAAGCCCATCTGTGGAATCCCTAAACTGCCTTCAAAGAAAGGGAGTTCCCCGATCTAAAATGGTCATTATATATTT
GTGTCAAGAATTAGAAGGCAAGGGTCACTAAATATTTTAAGGATTAAGGTACCAGAGGCATCAGTGGTATAAGGATGGAGTCTGGTCTTT
AATTACGACAAGGGTATTGCTTACATTCTACTCTCTGGTTTTCAAAAAGATCTGACATGCTGACAAATCCAGCTCCTCACAAATCTTGTT
TGAAGGACTTGTGGGAAGTGATATTCCTTACTATTAGATCACGCCCCTTATAACTACATGTTAACATCCAGCCTTTTATCTGTTTGAGTA
ATTGTAGGGATAGAAAGTGAAGCCCCCAGAGTTAGGTGCAAGTATAGCACCCAGCTGAAAGGCATCATGGAGTCTAAGGGCCTTCTACAG
AAGGGGCAATCCTTTGGGTTATTTCTGGTGTACCACTGTCTTCTCTACCTCGGTCCAACACCACCTCTCTTGGACAAAAAATAAAACAAG

>6447_6447_2_ARID2-ZNF641_ARID2_chr12_46125097_ENST00000334344_ZNF641_chr12_48741898_ENST00000544117_length(amino acids)=538AA_BP=105
MGFLKTSFEKIMANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFP
RSCSNAAFALKQYYLRSQFGSAAEMLSEQTAALGTGWESMNVQLDGAEPQVERGSQEERPWRTVPGPLEHLCCDLEEEPQSLQEKAQSAP
WVPAIPQEGNTGDWEMAAALLAAGSQGLVTIKDVSLCFSQEEWRSLDPSQTDFYGEYVMQENCGIVVSLRFPIPKLDMLSQLEGGEEQWV
PDPQDLEERDILRVTYTGDGSEHEGDTPELEAEPPRMLSSVSEDTVLWNPEHDESWDSMPSSSRGMLLGPPFLQEDSFSNLLCSTEMDSL
LRPHTCPQCGKQFVWGSHLARHQQTHTGERPYSCLKCEKTFGRRHHLIRHQKTHLHDKTSRCSECGKNFRCNSHLASHQRVHAEGKSCKG

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Fusion Gene PPI Analysis for ARID2-ZNF641


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARID2-ZNF641


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARID2-ZNF641


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARID2C2239176Liver carcinoma2CGI;CTD_human
HgeneARID2C0033578Prostatic Neoplasms1CTD_human
HgeneARID2C0265338Coffin-Siris syndrome1ORPHANET
HgeneARID2C0376358Malignant neoplasm of prostate1CTD_human