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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCA1-RAB5C (FusionGDB2 ID:HG19TG5878)

Fusion Gene Summary for ABCA1-RAB5C

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCA1-RAB5C
Fusion gene ID: hg19tg5878
HgeneTgene
Gene symbol

ABCA1

RAB5C

Gene ID

19

5878

Gene nameATP binding cassette subfamily A member 1RAB5C, member RAS oncogene family
SynonymsABC-1|ABC1|CERP|HDLCQTL13|HDLDT1|HPALP1|TGDL1880|RAB5CL|RAB5L|RABL
Cytomap('ABCA1')('RAB5C')

9q31.1

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionphospholipid-transporting ATPase ABCA1ATP-binding cassette sub-family A member 1ATP-binding cassette transporter A1ATP-binding cassette, sub-family A (ABC1), member 1cholesterol efflux regulatory proteinmembrane-boundras-related protein Rab-5CRAB5C, member of RAS oncogene family
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000374733, ENST00000374736, 
ENST00000423487, ENST00000494467, 
Fusion gene scores* DoF score13 X 9 X 9=10538 X 7 X 6=336
# samples 1310
** MAII scorelog2(13/1053*10)=-3.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCA1 [Title/Abstract] AND RAB5C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCA1(107645320)-RAB5C(40278866), # samples:1
Anticipated loss of major functional domain due to fusion event.ABCA1-RAB5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA1-RAB5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA1-RAB5C seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ABCA1-RAB5C seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCA1

GO:0007040

lysosome organization

15163665

HgeneABCA1

GO:0008203

cholesterol metabolic process

14747463

HgeneABCA1

GO:0016197

endosomal transport

14747463

HgeneABCA1

GO:0033344

cholesterol efflux

10431236|11162594|16702602|23931754

HgeneABCA1

GO:0033700

phospholipid efflux

10431236|11162594

HgeneABCA1

GO:0042632

cholesterol homeostasis

10431236

HgeneABCA1

GO:0045332

phospholipid translocation

24097981


check buttonFusion gene breakpoints across ABCA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RAB5C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-4Z-AA7Q-01AABCA1chr9

107645320

-RAB5Cchr17

40278866

-


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Fusion Gene ORF analysis for ABCA1-RAB5C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000374733ENST00000346213ABCA1chr9

107645320

-RAB5Cchr17

40278866

-
Frame-shiftENST00000374733ENST00000393860ABCA1chr9

107645320

-RAB5Cchr17

40278866

-
Frame-shiftENST00000374733ENST00000547517ABCA1chr9

107645320

-RAB5Cchr17

40278866

-
In-frameENST00000374736ENST00000346213ABCA1chr9

107645320

-RAB5Cchr17

40278866

-
In-frameENST00000374736ENST00000393860ABCA1chr9

107645320

-RAB5Cchr17

40278866

-
In-frameENST00000374736ENST00000547517ABCA1chr9

107645320

-RAB5Cchr17

40278866

-
In-frameENST00000423487ENST00000346213ABCA1chr9

107645320

-RAB5Cchr17

40278866

-
In-frameENST00000423487ENST00000393860ABCA1chr9

107645320

-RAB5Cchr17

40278866

-
In-frameENST00000423487ENST00000547517ABCA1chr9

107645320

-RAB5Cchr17

40278866

-
intron-3CDSENST00000494467ENST00000346213ABCA1chr9

107645320

-RAB5Cchr17

40278866

-
intron-3CDSENST00000494467ENST00000393860ABCA1chr9

107645320

-RAB5Cchr17

40278866

-
intron-3CDSENST00000494467ENST00000547517ABCA1chr9

107645320

-RAB5Cchr17

40278866

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374736ABCA1chr9107645320-ENST00000346213RAB5Cchr1740278866-183381612661784172
ENST00000374736ABCA1chr9107645320-ENST00000393860RAB5Cchr1740278866-182981612661784172
ENST00000374736ABCA1chr9107645320-ENST00000547517RAB5Cchr1740278866-1142816395913172
ENST00000423487ABCA1chr9107645320-ENST00000346213RAB5Cchr1740278866-1735718297815172
ENST00000423487ABCA1chr9107645320-ENST00000393860RAB5Cchr1740278866-1731718297815172
ENST00000423487ABCA1chr9107645320-ENST00000547517RAB5Cchr1740278866-1044718297815172

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374736ENST00000346213ABCA1chr9107645320-RAB5Cchr1740278866-0.137937160.8620629
ENST00000374736ENST00000393860ABCA1chr9107645320-RAB5Cchr1740278866-0.137625950.862374
ENST00000374736ENST00000547517ABCA1chr9107645320-RAB5Cchr1740278866-0.0888052360.91119474
ENST00000423487ENST00000346213ABCA1chr9107645320-RAB5Cchr1740278866-0.102874220.8971258
ENST00000423487ENST00000393860ABCA1chr9107645320-RAB5Cchr1740278866-0.101674950.8983251
ENST00000423487ENST00000547517ABCA1chr9107645320-RAB5Cchr1740278866-0.055887520.9441124

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Fusion Genomic Features for ABCA1-RAB5C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ABCA1-RAB5C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:107645320/chr17:40278866)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-55022_421402262.0TransmembraneHelical
TgeneRAB5Cchr9:107645320chr17:40278866ENST0000034621336164_166147217.0Nucleotide bindingGTP
TgeneRAB5Cchr9:107645320chr17:40278866ENST0000039386047164_166147217.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-5501912_21441402262.0DomainABC transporter 2
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-550899_11311402262.0DomainABC transporter 1
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-5501946_19531402262.0Nucleotide bindingATP 2
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-550933_9401402262.0Nucleotide bindingATP 1
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-5501372_16561402262.0Topological domainNote=Extracellular
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-55043_6391402262.0Topological domainNote=Extracellular
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-5501041_10571402262.0TransmembraneHelical
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-5501351_13711402262.0TransmembraneHelical
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-5501657_16771402262.0TransmembraneHelical
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-5501703_17231402262.0TransmembraneHelical
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-5501735_17551402262.0TransmembraneHelical
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-5501768_17881402262.0TransmembraneHelical
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-5501802_18221402262.0TransmembraneHelical
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-5501852_18721402262.0TransmembraneHelical
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-550640_6601402262.0TransmembraneHelical
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-550683_7031402262.0TransmembraneHelical
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-550716_7361402262.0TransmembraneHelical
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-550745_7651402262.0TransmembraneHelical
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-550777_7971402262.0TransmembraneHelical
HgeneABCA1chr9:107645320chr17:40278866ENST00000374736-550827_8471402262.0TransmembraneHelical
TgeneRAB5Cchr9:107645320chr17:40278866ENST000003462133650_58147217.0MotifEffector region
TgeneRAB5Cchr9:107645320chr17:40278866ENST000003938604750_58147217.0MotifEffector region
TgeneRAB5Cchr9:107645320chr17:40278866ENST000005475174750_58180250.0MotifEffector region
TgeneRAB5Cchr9:107645320chr17:40278866ENST0000034621336134_137147217.0Nucleotide bindingGTP
TgeneRAB5Cchr9:107645320chr17:40278866ENST000003462133628_36147217.0Nucleotide bindingGTP
TgeneRAB5Cchr9:107645320chr17:40278866ENST000003462133647_53147217.0Nucleotide bindingGTP
TgeneRAB5Cchr9:107645320chr17:40278866ENST000003462133676_80147217.0Nucleotide bindingGTP
TgeneRAB5Cchr9:107645320chr17:40278866ENST0000039386047134_137147217.0Nucleotide bindingGTP
TgeneRAB5Cchr9:107645320chr17:40278866ENST000003938604728_36147217.0Nucleotide bindingGTP
TgeneRAB5Cchr9:107645320chr17:40278866ENST000003938604747_53147217.0Nucleotide bindingGTP
TgeneRAB5Cchr9:107645320chr17:40278866ENST000003938604776_80147217.0Nucleotide bindingGTP
TgeneRAB5Cchr9:107645320chr17:40278866ENST0000054751747134_137180250.0Nucleotide bindingGTP
TgeneRAB5Cchr9:107645320chr17:40278866ENST0000054751747164_166180250.0Nucleotide bindingGTP
TgeneRAB5Cchr9:107645320chr17:40278866ENST000005475174728_36180250.0Nucleotide bindingGTP
TgeneRAB5Cchr9:107645320chr17:40278866ENST000005475174747_53180250.0Nucleotide bindingGTP
TgeneRAB5Cchr9:107645320chr17:40278866ENST000005475174776_80180250.0Nucleotide bindingGTP


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Fusion Gene Sequence for ABCA1-RAB5C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>173_173_1_ABCA1-RAB5C_ABCA1_chr9_107645320_ENST00000374736_RAB5C_chr17_40278866_ENST00000346213_length(transcript)=1833nt_BP=816nt
AGAGCACAGGCTTTGACCGATAGTAACCTCTGCGCTCGGTGCAGCCGAATCTATAAAAGGAACTAGTCCCGGCAAAAACCCCGTAATTGC
GAGCGAGAGTGAGTGGGGCCGGGACCCGCAGAGCCGAGCCGACCCTTCTCTCCCGGGCTGCGGCAGGGCAGGGCGGGGAGCTCCGCGCAC
CAACAGAGCCGGTTCTCAGGGCGCTTTGCTCCTTGTTTTTTCCCCGGTTCTGTTTTCTCCCCTTCTCCGGAAGGCTTGTCAAGGGGTAGG
AGAAAGAGACGCAAACACAAAAGTGGAAAACAGTTAATGACCAGCCACGGCGTCCCTGCTGTGAGCTCTGGCCGCTGCCTTCCAGGGCTC
CCGAGCCACACGCTGGGGGTGCTGGCTGAGGGAACATGGCTTGTTGGCCTCAGCTGAGGTTGCTGCTGTGGAAGAACCTCACTTTCAGAA
GAAGACAAACATGTCAGCTGCTGCTGGAAGTGGCCTGGCCTCTATTTATCTTCCTGATCCTGATCTCTGTTCGGCTGAGCTACCCACCCT
ATGAACAACATGAATGCCATTTTCCAAATAAAGCCATGCCCTCTGCAGGAACACTTCCTTGGGTTCAGGGGATTATCTGTAATGCCAACA
ACCCCTGTTTCCGTTACCCGACTCCTGGGGAGGCTCCCGGAGTTGTTGGAAACTTTAACAAATCCATTGTGGCTCGCCTGTTCTCAGATG
CTCGGAGGCTTCTTTTATACAGCCAGAAAGACACCAGCATGAAGGACATGCGCAAAGTTCTGAGAACATTACAGCAGATCAAGAAATCCA
GCTCAAGAAGCACAAGCCTATGCAGACGACAACAGTTTGCTGTTCATGGAGACATCAGCAAAGACTGCAATGAACGTGAACGAAATCTTC
ATGGCAATAGCTAAGAAGCTTCCCAAGAACGAGCCCCAGAATGCAACTGGTGCTCCAGGCCGAAACCGAGGTGTGGACCTCCAGGAGAAC
AACCCAGCCAGCCGGAGCCAGTGCTGCAGCAACTGAGCCCCCCTTGCCTGCCCGCTGCCCCCGCCTCCTCCGCCTGAATGACCCGACTGG
AATCCACTCTAACCAATCGCACTTAACGACTCGGGCCACCACTGGGGGGGCAGGGGGAGGGGTCCACCATGATTTCTCCATATAATTTTG
ATCATAGGCCGGAGTGAGTCATTCCACCTGCACCTTTCTGTACAAATACTAATTCAATTTTAAGTCTTAAGTCACTTTTTTAATATATAT
GATCTTCTGCTCTTCCCACTTCCTCCCCTTTCTACTGCTCTCCCATTTTCCCTTGCTGGGAGTAGCCACATGCTCTTGCCCCCCAACCCT
TGTATATGGGGACAGTGGGGTCAGTGCAGCTACCCTTTCTTTCCCTCCTGCGGAACAGCGGACCCAGCAAGAGCATCCACATCCTCACTT
TGTTCGGAGTGGTCTTTGGTTTGGGCGGTGGGGCAGACCTTGGGAAGGGGCTTAGGAAGGGAGAGGCAGCTCTTCCTTCAGCTGGCTCTC
ATCAGGCTGCAGCCCCCTCCCCGCTCCCACCTCCCTGCTGGGAAACCACAGCATTATCACAGCATTATTGTGACAGCCACGAACCCATTG
CCCACAACCCCTCCACCCTCGGTCACCCCAACCTCTGGCTCTGAGCCCTGTTCTGACCAAATCATGATGATGAGTATTTGGGGGTGGGTG
GGTAAGGGGGGGAGTGGGAGGGGACGGAACCAACTTTTTCTGTATTTTGTATTGTATGTTTTCTTCAACATGTAACCAATCAGTATCTTG

>173_173_1_ABCA1-RAB5C_ABCA1_chr9_107645320_ENST00000374736_RAB5C_chr17_40278866_ENST00000346213_length(amino acids)=172AA_BP=
MLFPLPPLSTALPFSLAGSSHMLLPPNPCIWGQWGQCSYPFFPSCGTADPARASTSSLCSEWSLVWAVGQTLGRGLGRERQLFLQLALIR

--------------------------------------------------------------
>173_173_2_ABCA1-RAB5C_ABCA1_chr9_107645320_ENST00000374736_RAB5C_chr17_40278866_ENST00000393860_length(transcript)=1829nt_BP=816nt
AGAGCACAGGCTTTGACCGATAGTAACCTCTGCGCTCGGTGCAGCCGAATCTATAAAAGGAACTAGTCCCGGCAAAAACCCCGTAATTGC
GAGCGAGAGTGAGTGGGGCCGGGACCCGCAGAGCCGAGCCGACCCTTCTCTCCCGGGCTGCGGCAGGGCAGGGCGGGGAGCTCCGCGCAC
CAACAGAGCCGGTTCTCAGGGCGCTTTGCTCCTTGTTTTTTCCCCGGTTCTGTTTTCTCCCCTTCTCCGGAAGGCTTGTCAAGGGGTAGG
AGAAAGAGACGCAAACACAAAAGTGGAAAACAGTTAATGACCAGCCACGGCGTCCCTGCTGTGAGCTCTGGCCGCTGCCTTCCAGGGCTC
CCGAGCCACACGCTGGGGGTGCTGGCTGAGGGAACATGGCTTGTTGGCCTCAGCTGAGGTTGCTGCTGTGGAAGAACCTCACTTTCAGAA
GAAGACAAACATGTCAGCTGCTGCTGGAAGTGGCCTGGCCTCTATTTATCTTCCTGATCCTGATCTCTGTTCGGCTGAGCTACCCACCCT
ATGAACAACATGAATGCCATTTTCCAAATAAAGCCATGCCCTCTGCAGGAACACTTCCTTGGGTTCAGGGGATTATCTGTAATGCCAACA
ACCCCTGTTTCCGTTACCCGACTCCTGGGGAGGCTCCCGGAGTTGTTGGAAACTTTAACAAATCCATTGTGGCTCGCCTGTTCTCAGATG
CTCGGAGGCTTCTTTTATACAGCCAGAAAGACACCAGCATGAAGGACATGCGCAAAGTTCTGAGAACATTACAGCAGATCAAGAAATCCA
GCTCAAGAAGCACAAGCCTATGCAGACGACAACAGTTTGCTGTTCATGGAGACATCAGCAAAGACTGCAATGAACGTGAACGAAATCTTC
ATGGCAATAGCTAAGAAGCTTCCCAAGAACGAGCCCCAGAATGCAACTGGTGCTCCAGGCCGAAACCGAGGTGTGGACCTCCAGGAGAAC
AACCCAGCCAGCCGGAGCCAGTGCTGCAGCAACTGAGCCCCCCTTGCCTGCCCGCTGCCCCCGCCTCCTCCGCCTGAATGACCCGACTGG
AATCCACTCTAACCAATCGCACTTAACGACTCGGGCCACCACTGGGGGGGCAGGGGGAGGGGTCCACCATGATTTCTCCATATAATTTTG
ATCATAGGCCGGAGTGAGTCATTCCACCTGCACCTTTCTGTACAAATACTAATTCAATTTTAAGTCTTAAGTCACTTTTTTAATATATAT
GATCTTCTGCTCTTCCCACTTCCTCCCCTTTCTACTGCTCTCCCATTTTCCCTTGCTGGGAGTAGCCACATGCTCTTGCCCCCCAACCCT
TGTATATGGGGACAGTGGGGTCAGTGCAGCTACCCTTTCTTTCCCTCCTGCGGAACAGCGGACCCAGCAAGAGCATCCACATCCTCACTT
TGTTCGGAGTGGTCTTTGGTTTGGGCGGTGGGGCAGACCTTGGGAAGGGGCTTAGGAAGGGAGAGGCAGCTCTTCCTTCAGCTGGCTCTC
ATCAGGCTGCAGCCCCCTCCCCGCTCCCACCTCCCTGCTGGGAAACCACAGCATTATCACAGCATTATTGTGACAGCCACGAACCCATTG
CCCACAACCCCTCCACCCTCGGTCACCCCAACCTCTGGCTCTGAGCCCTGTTCTGACCAAATCATGATGATGAGTATTTGGGGGTGGGTG
GGTAAGGGGGGGAGTGGGAGGGGACGGAACCAACTTTTTCTGTATTTTGTATTGTATGTTTTCTTCAACATGTAACCAATCAGTATCTTG

>173_173_2_ABCA1-RAB5C_ABCA1_chr9_107645320_ENST00000374736_RAB5C_chr17_40278866_ENST00000393860_length(amino acids)=172AA_BP=
MLFPLPPLSTALPFSLAGSSHMLLPPNPCIWGQWGQCSYPFFPSCGTADPARASTSSLCSEWSLVWAVGQTLGRGLGRERQLFLQLALIR

--------------------------------------------------------------
>173_173_3_ABCA1-RAB5C_ABCA1_chr9_107645320_ENST00000374736_RAB5C_chr17_40278866_ENST00000547517_length(transcript)=1142nt_BP=816nt
AGAGCACAGGCTTTGACCGATAGTAACCTCTGCGCTCGGTGCAGCCGAATCTATAAAAGGAACTAGTCCCGGCAAAAACCCCGTAATTGC
GAGCGAGAGTGAGTGGGGCCGGGACCCGCAGAGCCGAGCCGACCCTTCTCTCCCGGGCTGCGGCAGGGCAGGGCGGGGAGCTCCGCGCAC
CAACAGAGCCGGTTCTCAGGGCGCTTTGCTCCTTGTTTTTTCCCCGGTTCTGTTTTCTCCCCTTCTCCGGAAGGCTTGTCAAGGGGTAGG
AGAAAGAGACGCAAACACAAAAGTGGAAAACAGTTAATGACCAGCCACGGCGTCCCTGCTGTGAGCTCTGGCCGCTGCCTTCCAGGGCTC
CCGAGCCACACGCTGGGGGTGCTGGCTGAGGGAACATGGCTTGTTGGCCTCAGCTGAGGTTGCTGCTGTGGAAGAACCTCACTTTCAGAA
GAAGACAAACATGTCAGCTGCTGCTGGAAGTGGCCTGGCCTCTATTTATCTTCCTGATCCTGATCTCTGTTCGGCTGAGCTACCCACCCT
ATGAACAACATGAATGCCATTTTCCAAATAAAGCCATGCCCTCTGCAGGAACACTTCCTTGGGTTCAGGGGATTATCTGTAATGCCAACA
ACCCCTGTTTCCGTTACCCGACTCCTGGGGAGGCTCCCGGAGTTGTTGGAAACTTTAACAAATCCATTGTGGCTCGCCTGTTCTCAGATG
CTCGGAGGCTTCTTTTATACAGCCAGAAAGACACCAGCATGAAGGACATGCGCAAAGTTCTGAGAACATTACAGCAGATCAAGAAATCCA
GCTCAAGAAGCACAAGCCTATGCAGACGACAACAGTTTGCTGTTCATGGAGACATCAGCAAAGACTGCAATGAACGTGAACGAAATCTTC
ATGGCAATAGCTAAGAAGCTTCCCAAGAACGAGCCCCAGAATGCAACTGGTGCTCCAGGCCGAAACCGAGGTGTGGACCTCCAGGAGAAC
AACCCAGCCAGCCGGAGCCAGTGCTGCAGCAACTGAGCCCCCCTTGCCTGCCCGCTGCCCCCGCCTCCTCCGCCTGAATGACCCGACTGG

>173_173_3_ABCA1-RAB5C_ABCA1_chr9_107645320_ENST00000374736_RAB5C_chr17_40278866_ENST00000547517_length(amino acids)=172AA_BP=141
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEA

--------------------------------------------------------------
>173_173_4_ABCA1-RAB5C_ABCA1_chr9_107645320_ENST00000423487_RAB5C_chr17_40278866_ENST00000346213_length(transcript)=1735nt_BP=718nt
GTGAGTGGGGCCGGGACCCGCAGAGCCGAGCCGACCCTTCTCTCCCGGGCTGCGGCAGGGCAGGGCGGGGAGCTCCGCGCACCAACAGAG
CCGGTTCTCAGGGCGCTTTGCTCCTTGTTTTTTCCCCGGTTCTGTTTTCTCCCCTTCTCCGGAAGGCTTGTCAAGGGGTAGGAGAAAGAG
ACGCAAACACAAAAGTGGAAAACAGTTAATGACCAGCCACGGCGTCCCTGCTGTGAGCTCTGGCCGCTGCCTTCCAGGGCTCCCGAGCCA
CACGCTGGGGGTGCTGGCTGAGGGAACATGGCTTGTTGGCCTCAGCTGAGGTTGCTGCTGTGGAAGAACCTCACTTTCAGAAGAAGACAA
ACATGTCAGCTGCTGCTGGAAGTGGCCTGGCCTCTATTTATCTTCCTGATCCTGATCTCTGTTCGGCTGAGCTACCCACCCTATGAACAA
CATGAATGCCATTTTCCAAATAAAGCCATGCCCTCTGCAGGAACACTTCCTTGGGTTCAGGGGATTATCTGTAATGCCAACAACCCCTGT
TTCCGTTACCCGACTCCTGGGGAGGCTCCCGGAGTTGTTGGAAACTTTAACAAATCCATTGTGGCTCGCCTGTTCTCAGATGCTCGGAGG
CTTCTTTTATACAGCCAGAAAGACACCAGCATGAAGGACATGCGCAAAGTTCTGAGAACATTACAGCAGATCAAGAAATCCAGCTCAAGA
AGCACAAGCCTATGCAGACGACAACAGTTTGCTGTTCATGGAGACATCAGCAAAGACTGCAATGAACGTGAACGAAATCTTCATGGCAAT
AGCTAAGAAGCTTCCCAAGAACGAGCCCCAGAATGCAACTGGTGCTCCAGGCCGAAACCGAGGTGTGGACCTCCAGGAGAACAACCCAGC
CAGCCGGAGCCAGTGCTGCAGCAACTGAGCCCCCCTTGCCTGCCCGCTGCCCCCGCCTCCTCCGCCTGAATGACCCGACTGGAATCCACT
CTAACCAATCGCACTTAACGACTCGGGCCACCACTGGGGGGGCAGGGGGAGGGGTCCACCATGATTTCTCCATATAATTTTGATCATAGG
CCGGAGTGAGTCATTCCACCTGCACCTTTCTGTACAAATACTAATTCAATTTTAAGTCTTAAGTCACTTTTTTAATATATATGATCTTCT
GCTCTTCCCACTTCCTCCCCTTTCTACTGCTCTCCCATTTTCCCTTGCTGGGAGTAGCCACATGCTCTTGCCCCCCAACCCTTGTATATG
GGGACAGTGGGGTCAGTGCAGCTACCCTTTCTTTCCCTCCTGCGGAACAGCGGACCCAGCAAGAGCATCCACATCCTCACTTTGTTCGGA
GTGGTCTTTGGTTTGGGCGGTGGGGCAGACCTTGGGAAGGGGCTTAGGAAGGGAGAGGCAGCTCTTCCTTCAGCTGGCTCTCATCAGGCT
GCAGCCCCCTCCCCGCTCCCACCTCCCTGCTGGGAAACCACAGCATTATCACAGCATTATTGTGACAGCCACGAACCCATTGCCCACAAC
CCCTCCACCCTCGGTCACCCCAACCTCTGGCTCTGAGCCCTGTTCTGACCAAATCATGATGATGAGTATTTGGGGGTGGGTGGGTAAGGG
GGGGAGTGGGAGGGGACGGAACCAACTTTTTCTGTATTTTGTATTGTATGTTTTCTTCAACATGTAACCAATCAGTATCTTGTCAATATA

>173_173_4_ABCA1-RAB5C_ABCA1_chr9_107645320_ENST00000423487_RAB5C_chr17_40278866_ENST00000346213_length(amino acids)=172AA_BP=141
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEA

--------------------------------------------------------------
>173_173_5_ABCA1-RAB5C_ABCA1_chr9_107645320_ENST00000423487_RAB5C_chr17_40278866_ENST00000393860_length(transcript)=1731nt_BP=718nt
GTGAGTGGGGCCGGGACCCGCAGAGCCGAGCCGACCCTTCTCTCCCGGGCTGCGGCAGGGCAGGGCGGGGAGCTCCGCGCACCAACAGAG
CCGGTTCTCAGGGCGCTTTGCTCCTTGTTTTTTCCCCGGTTCTGTTTTCTCCCCTTCTCCGGAAGGCTTGTCAAGGGGTAGGAGAAAGAG
ACGCAAACACAAAAGTGGAAAACAGTTAATGACCAGCCACGGCGTCCCTGCTGTGAGCTCTGGCCGCTGCCTTCCAGGGCTCCCGAGCCA
CACGCTGGGGGTGCTGGCTGAGGGAACATGGCTTGTTGGCCTCAGCTGAGGTTGCTGCTGTGGAAGAACCTCACTTTCAGAAGAAGACAA
ACATGTCAGCTGCTGCTGGAAGTGGCCTGGCCTCTATTTATCTTCCTGATCCTGATCTCTGTTCGGCTGAGCTACCCACCCTATGAACAA
CATGAATGCCATTTTCCAAATAAAGCCATGCCCTCTGCAGGAACACTTCCTTGGGTTCAGGGGATTATCTGTAATGCCAACAACCCCTGT
TTCCGTTACCCGACTCCTGGGGAGGCTCCCGGAGTTGTTGGAAACTTTAACAAATCCATTGTGGCTCGCCTGTTCTCAGATGCTCGGAGG
CTTCTTTTATACAGCCAGAAAGACACCAGCATGAAGGACATGCGCAAAGTTCTGAGAACATTACAGCAGATCAAGAAATCCAGCTCAAGA
AGCACAAGCCTATGCAGACGACAACAGTTTGCTGTTCATGGAGACATCAGCAAAGACTGCAATGAACGTGAACGAAATCTTCATGGCAAT
AGCTAAGAAGCTTCCCAAGAACGAGCCCCAGAATGCAACTGGTGCTCCAGGCCGAAACCGAGGTGTGGACCTCCAGGAGAACAACCCAGC
CAGCCGGAGCCAGTGCTGCAGCAACTGAGCCCCCCTTGCCTGCCCGCTGCCCCCGCCTCCTCCGCCTGAATGACCCGACTGGAATCCACT
CTAACCAATCGCACTTAACGACTCGGGCCACCACTGGGGGGGCAGGGGGAGGGGTCCACCATGATTTCTCCATATAATTTTGATCATAGG
CCGGAGTGAGTCATTCCACCTGCACCTTTCTGTACAAATACTAATTCAATTTTAAGTCTTAAGTCACTTTTTTAATATATATGATCTTCT
GCTCTTCCCACTTCCTCCCCTTTCTACTGCTCTCCCATTTTCCCTTGCTGGGAGTAGCCACATGCTCTTGCCCCCCAACCCTTGTATATG
GGGACAGTGGGGTCAGTGCAGCTACCCTTTCTTTCCCTCCTGCGGAACAGCGGACCCAGCAAGAGCATCCACATCCTCACTTTGTTCGGA
GTGGTCTTTGGTTTGGGCGGTGGGGCAGACCTTGGGAAGGGGCTTAGGAAGGGAGAGGCAGCTCTTCCTTCAGCTGGCTCTCATCAGGCT
GCAGCCCCCTCCCCGCTCCCACCTCCCTGCTGGGAAACCACAGCATTATCACAGCATTATTGTGACAGCCACGAACCCATTGCCCACAAC
CCCTCCACCCTCGGTCACCCCAACCTCTGGCTCTGAGCCCTGTTCTGACCAAATCATGATGATGAGTATTTGGGGGTGGGTGGGTAAGGG
GGGGAGTGGGAGGGGACGGAACCAACTTTTTCTGTATTTTGTATTGTATGTTTTCTTCAACATGTAACCAATCAGTATCTTGTCAATATA

>173_173_5_ABCA1-RAB5C_ABCA1_chr9_107645320_ENST00000423487_RAB5C_chr17_40278866_ENST00000393860_length(amino acids)=172AA_BP=141
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEA

--------------------------------------------------------------
>173_173_6_ABCA1-RAB5C_ABCA1_chr9_107645320_ENST00000423487_RAB5C_chr17_40278866_ENST00000547517_length(transcript)=1044nt_BP=718nt
GTGAGTGGGGCCGGGACCCGCAGAGCCGAGCCGACCCTTCTCTCCCGGGCTGCGGCAGGGCAGGGCGGGGAGCTCCGCGCACCAACAGAG
CCGGTTCTCAGGGCGCTTTGCTCCTTGTTTTTTCCCCGGTTCTGTTTTCTCCCCTTCTCCGGAAGGCTTGTCAAGGGGTAGGAGAAAGAG
ACGCAAACACAAAAGTGGAAAACAGTTAATGACCAGCCACGGCGTCCCTGCTGTGAGCTCTGGCCGCTGCCTTCCAGGGCTCCCGAGCCA
CACGCTGGGGGTGCTGGCTGAGGGAACATGGCTTGTTGGCCTCAGCTGAGGTTGCTGCTGTGGAAGAACCTCACTTTCAGAAGAAGACAA
ACATGTCAGCTGCTGCTGGAAGTGGCCTGGCCTCTATTTATCTTCCTGATCCTGATCTCTGTTCGGCTGAGCTACCCACCCTATGAACAA
CATGAATGCCATTTTCCAAATAAAGCCATGCCCTCTGCAGGAACACTTCCTTGGGTTCAGGGGATTATCTGTAATGCCAACAACCCCTGT
TTCCGTTACCCGACTCCTGGGGAGGCTCCCGGAGTTGTTGGAAACTTTAACAAATCCATTGTGGCTCGCCTGTTCTCAGATGCTCGGAGG
CTTCTTTTATACAGCCAGAAAGACACCAGCATGAAGGACATGCGCAAAGTTCTGAGAACATTACAGCAGATCAAGAAATCCAGCTCAAGA
AGCACAAGCCTATGCAGACGACAACAGTTTGCTGTTCATGGAGACATCAGCAAAGACTGCAATGAACGTGAACGAAATCTTCATGGCAAT
AGCTAAGAAGCTTCCCAAGAACGAGCCCCAGAATGCAACTGGTGCTCCAGGCCGAAACCGAGGTGTGGACCTCCAGGAGAACAACCCAGC
CAGCCGGAGCCAGTGCTGCAGCAACTGAGCCCCCCTTGCCTGCCCGCTGCCCCCGCCTCCTCCGCCTGAATGACCCGACTGGAATCCACT

>173_173_6_ABCA1-RAB5C_ABCA1_chr9_107645320_ENST00000423487_RAB5C_chr17_40278866_ENST00000547517_length(amino acids)=172AA_BP=141
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ABCA1-RAB5C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCA1-RAB5C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCA1-RAB5C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCA1C0039292Tangier Disease23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneABCA1C1704429Hypoalphalipoproteinemia, Familial9CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneABCA1C0751544Tangier Disease Neuropathy3CTD_human
HgeneABCA1C0342898Apolipoprotein A-I deficiency2ORPHANET
HgeneABCA1C2931838Familial HDL deficiency2CTD_human
HgeneABCA1C3711531Hdl Deficiency, Type 22CTD_human
HgeneABCA1C0004153Atherosclerosis1CTD_human
HgeneABCA1C0009402Colorectal Carcinoma1CTD_human;UNIPROT
HgeneABCA1C0009404Colorectal Neoplasms1CTD_human
HgeneABCA1C0020443Hypercholesterolemia1CTD_human;GENOMICS_ENGLAND
HgeneABCA1C0020445Hypercholesterolemia, Familial1CTD_human
HgeneABCA1C0022661Kidney Failure, Chronic1CTD_human
HgeneABCA1C0036341Schizophrenia1PSYGENET
HgeneABCA1C0745103Hyperlipoproteinemia Type IIa1CTD_human;GENOMICS_ENGLAND
HgeneABCA1C1563937Atherogenesis1CTD_human
HgeneABCA1C1704417Hyperlipoproteinemia Type IIb1CTD_human
HgeneABCA1C4721453Peripheral Nervous System Diseases1CTD_human