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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EML1-ADAMDEC1 (FusionGDB2 ID:HG2009TG27299)

Fusion Gene Summary for EML1-ADAMDEC1

check button Fusion gene summary
Fusion gene informationFusion gene name: EML1-ADAMDEC1
Fusion gene ID: hg2009tg27299
HgeneTgene
Gene symbol

EML1

ADAMDEC1

Gene ID

2009

27299

Gene nameEMAP like 1ADAM like decysin 1
SynonymsBH|ELP79|EMAP|EMAP-1|EMAPLM12.219
Cytomap('EML1')('ADAMDEC1')

14q32.2

8p21.2

Type of geneprotein-codingprotein-coding
Descriptionechinoderm microtubule-associated protein-like 1echinoderm microtubule associated protein like 1ADAM DEC1ADAM-like protein decysin-1a disintegrin and metalloproteinase domain-like protein decysin-1decysindisintegrin protease
Modification date2020031320200313
UniProtAcc

O00423

O15204

Ensembl transtripts involved in fusion geneENST00000262233, ENST00000334192, 
ENST00000327921, ENST00000556758, 
Fusion gene scores* DoF score15 X 8 X 11=13202 X 3 X 2=12
# samples 173
** MAII scorelog2(17/1320*10)=-2.95693127810811
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EML1 [Title/Abstract] AND ADAMDEC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEML1(100259880)-ADAMDEC1(24241972), # samples:2
EML1(100259880)-ADAMDEC1(24249775), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-63-A5ML-01AEML1chr14

100259880

+ADAMDEC1chr8

24241972

+
ChimerDB4LUSCTCGA-63-A5ML-01AEML1chr14

100259880

-ADAMDEC1chr8

24249775

+
ChimerDB4LUSCTCGA-63-A5MLEML1chr14

100259880

+ADAMDEC1chr8

24241972

+
ChimerDB4LUSCTCGA-63-A5MLEML1chr14

100259880

+ADAMDEC1chr8

24249775

+


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Fusion Gene ORF analysis for EML1-ADAMDEC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000262233ENST00000256412EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
5CDS-5UTRENST00000262233ENST00000256412EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
5CDS-5UTRENST00000262233ENST00000538205EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
5CDS-5UTRENST00000262233ENST00000538205EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
5CDS-5UTRENST00000334192ENST00000256412EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
5CDS-5UTRENST00000334192ENST00000256412EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
5CDS-5UTRENST00000334192ENST00000538205EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
5CDS-5UTRENST00000334192ENST00000538205EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
5CDS-intronENST00000262233ENST00000519953EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
5CDS-intronENST00000262233ENST00000519953EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
5CDS-intronENST00000262233ENST00000522298EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
5CDS-intronENST00000262233ENST00000522298EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
5CDS-intronENST00000334192ENST00000519953EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
5CDS-intronENST00000334192ENST00000519953EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
5CDS-intronENST00000334192ENST00000522298EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
5CDS-intronENST00000334192ENST00000522298EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
intron-5UTRENST00000327921ENST00000256412EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
intron-5UTRENST00000327921ENST00000256412EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
intron-5UTRENST00000327921ENST00000538205EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
intron-5UTRENST00000327921ENST00000538205EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
intron-5UTRENST00000556758ENST00000256412EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
intron-5UTRENST00000556758ENST00000256412EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
intron-5UTRENST00000556758ENST00000538205EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
intron-5UTRENST00000556758ENST00000538205EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
intron-intronENST00000327921ENST00000519953EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
intron-intronENST00000327921ENST00000519953EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
intron-intronENST00000327921ENST00000522298EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
intron-intronENST00000327921ENST00000522298EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
intron-intronENST00000556758ENST00000519953EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
intron-intronENST00000556758ENST00000519953EML1chr14

100259880

+ADAMDEC1chr8

24249775

+
intron-intronENST00000556758ENST00000522298EML1chr14

100259880

+ADAMDEC1chr8

24241972

+
intron-intronENST00000556758ENST00000522298EML1chr14

100259880

+ADAMDEC1chr8

24249775

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for EML1-ADAMDEC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EML1chr14100259880+ADAMDEC1chr824249774+1.97E-101
EML1chr14100259880+ADAMDEC1chr824249774+1.97E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EML1-ADAMDEC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:100259880/:24241972)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EML1

O00423

ADAMDEC1

O15204

FUNCTION: Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. {ECO:0000250|UniProtKB:Q05BC3}.FUNCTION: May play an important role in the control of the immune response and during pregnancy. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EML1-ADAMDEC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EML1-ADAMDEC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EML1-ADAMDEC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EML1-ADAMDEC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEML1C4284594BAND HETEROTOPIA2GENOMICS_ENGLAND;UNIPROT
HgeneEML1C1848201Subcortical Band Heterotopia1ORPHANET