Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:EPB41L2-STAT3 (FusionGDB2 ID:HG2037TG6774)

Fusion Gene Summary for EPB41L2-STAT3

check button Fusion gene summary
Fusion gene informationFusion gene name: EPB41L2-STAT3
Fusion gene ID: hg2037tg6774
HgeneTgene
Gene symbol

EPB41L2

STAT3

Gene ID

2037

6774

Gene nameerythrocyte membrane protein band 4.1 like 2signal transducer and activator of transcription 3
Synonyms4.1-G|4.1GADMIO|ADMIO1|APRF|HIES
Cytomap('EPB41L2')('STAT3')

6q23.1-q23.2

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionband 4.1-like protein 2erythrocyte membrane protein band 4.1 like-protein 2generally expressed protein 4.1signal transducer and activator of transcription 3DNA-binding protein APRFacute-phase response factor
Modification date2020031320200329
UniProtAcc

O43491

.
Ensembl transtripts involved in fusion geneENST00000337057, ENST00000368128, 
ENST00000392427, ENST00000445890, 
ENST00000525271, ENST00000527411, 
ENST00000530481, ENST00000524581, 
ENST00000525193, ENST00000527659, 
ENST00000528282, ENST00000529208, 
ENST00000530148, ENST00000530757, 
ENST00000531410, 
Fusion gene scores* DoF score12 X 11 X 7=92417 X 21 X 8=2856
# samples 1321
** MAII scorelog2(13/924*10)=-2.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(21/2856*10)=-3.76553474636298
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EPB41L2 [Title/Abstract] AND STAT3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEPB41L2(131384295)-STAT3(40474512), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTAT3

GO:0006355

regulation of transcription, DNA-templated

15664994|17344214

TgeneSTAT3

GO:0006606

protein import into nucleus

18234692

TgeneSTAT3

GO:0010507

negative regulation of autophagy

26962683

TgeneSTAT3

GO:0010628

positive regulation of gene expression

23820254

TgeneSTAT3

GO:0030522

intracellular receptor signaling pathway

17324931

TgeneSTAT3

GO:0032355

response to estradiol

12552091

TgeneSTAT3

GO:0032870

cellular response to hormone stimulus

12552091

TgeneSTAT3

GO:0033210

leptin-mediated signaling pathway

17344214

TgeneSTAT3

GO:0035278

miRNA mediated inhibition of translation

23820254

TgeneSTAT3

GO:0044320

cellular response to leptin stimulus

17344214

TgeneSTAT3

GO:0044321

response to leptin

17344214

TgeneSTAT3

GO:0045893

positive regulation of transcription, DNA-templated

19390056

TgeneSTAT3

GO:0045944

positive regulation of transcription by RNA polymerase II

17324931|27050391|31462771

TgeneSTAT3

GO:0051726

regulation of cell cycle

17344214

TgeneSTAT3

GO:0060396

growth hormone receptor signaling pathway

10925297

TgeneSTAT3

GO:0060397

JAK-STAT cascade involved in growth hormone signaling pathway

12552091

TgeneSTAT3

GO:0070102

interleukin-6-mediated signaling pathway

12359225|12552091|17324931|24429361

TgeneSTAT3

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

19390056|23820254

TgeneSTAT3

GO:2000637

positive regulation of gene silencing by miRNA

23820254



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-G4-6317-02AEPB41L2chr6

131384282

-STAT3chr17

40474512

-
ChimerDB4COADTCGA-G4-6317-02AEPB41L2chr6

131384295

-STAT3chr17

40469242

-
ChimerDB4COADTCGA-G4-6317-02AEPB41L2chr6

131384295

-STAT3chr17

40474512

-
ChimerDB4COADTCGA-G4-6317EPB41L2chr6

131384294

-STAT3chr17

40474512

-


Top

Fusion Gene ORF analysis for EPB41L2-STAT3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000337057ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
5UTR-3CDSENST00000337057ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
5UTR-3CDSENST00000337057ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
5UTR-3CDSENST00000337057ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
5UTR-3CDSENST00000337057ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
5UTR-3CDSENST00000337057ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
5UTR-3CDSENST00000337057ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
5UTR-3CDSENST00000337057ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
5UTR-3CDSENST00000337057ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
5UTR-3CDSENST00000337057ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
5UTR-3CDSENST00000337057ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
5UTR-3CDSENST00000337057ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
5UTR-3CDSENST00000337057ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
5UTR-3CDSENST00000337057ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
5UTR-3CDSENST00000337057ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
5UTR-3CDSENST00000368128ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000368128ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000368128ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000368128ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000368128ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000392427ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
5UTR-3CDSENST00000392427ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
5UTR-3CDSENST00000392427ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
5UTR-3CDSENST00000392427ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
5UTR-3CDSENST00000392427ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
5UTR-3CDSENST00000392427ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
5UTR-3CDSENST00000392427ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
5UTR-3CDSENST00000392427ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
5UTR-3CDSENST00000392427ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
5UTR-3CDSENST00000392427ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
5UTR-3CDSENST00000392427ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
5UTR-3CDSENST00000392427ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
5UTR-3CDSENST00000392427ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
5UTR-3CDSENST00000392427ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
5UTR-3CDSENST00000392427ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
5UTR-3CDSENST00000445890ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000445890ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000445890ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000445890ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000445890ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000525271ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000525271ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000525271ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000525271ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000525271ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000527411ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000527411ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000527411ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000527411ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000527411ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000530481ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000530481ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000530481ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000530481ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-3CDSENST00000530481ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-intronENST00000337057ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
5UTR-intronENST00000337057ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
5UTR-intronENST00000337057ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
5UTR-intronENST00000368128ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-intronENST00000392427ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
5UTR-intronENST00000392427ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
5UTR-intronENST00000392427ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
5UTR-intronENST00000445890ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-intronENST00000525271ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-intronENST00000527411ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
5UTR-intronENST00000530481ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000337057ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000337057ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000337057ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000337057ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000337057ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000368128ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000368128ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000368128ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000368128ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000368128ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000368128ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000368128ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000368128ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000368128ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000368128ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000368128ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000368128ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000368128ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000368128ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000368128ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000392427ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000392427ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000392427ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000392427ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000392427ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000445890ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000445890ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000445890ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000445890ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000445890ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000445890ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000445890ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000445890ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000445890ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000445890ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000445890ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000445890ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000445890ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000445890ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000445890ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000524581ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000524581ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000524581ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000524581ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000524581ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000524581ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000525193ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000525193ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000525193ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000525193ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000525193ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000525193ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000525271ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000525271ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000525271ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000525271ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000525271ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000525271ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000525271ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000525271ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000525271ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000525271ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000525271ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000525271ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000525271ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000525271ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000525271ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000527411ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000527411ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000527411ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000527411ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000527411ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000527411ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000527411ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000527411ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000527411ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000527411ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000527411ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000527411ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000527411ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000527411ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000527411ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000527659ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000527659ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000527659ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000527659ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000527659ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000527659ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000528282ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000528282ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000528282ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000528282ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000528282ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000528282ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000529208ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000529208ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000529208ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000529208ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000529208ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000529208ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530148ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530148ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530148ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530148ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530148ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530148ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530481ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530481ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530481ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530481ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530481ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530481ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530481ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530481ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530481ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530481ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530481ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530481ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530481ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530481ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530481ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530757ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530757ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530757ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530757ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000530757ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000530757ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000264657EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000531410ENST00000264657EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000264657EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000389272EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000531410ENST00000389272EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000389272EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000404395EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000531410ENST00000404395EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000404395EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000585517EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000531410ENST00000585517EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000585517EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000588969EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-3CDSENST00000531410ENST00000588969EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-3CDSENST00000531410ENST00000588969EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-intronENST00000337057ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-intronENST00000368128ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-intronENST00000368128ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-intronENST00000368128ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-intronENST00000392427ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-intronENST00000445890ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-intronENST00000445890ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-intronENST00000445890ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-intronENST00000524581ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-intronENST00000524581ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-intronENST00000524581ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-intronENST00000524581ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-intronENST00000525193ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-intronENST00000525193ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-intronENST00000525193ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-intronENST00000525193ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-intronENST00000525271ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-intronENST00000525271ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-intronENST00000525271ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-intronENST00000527411ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-intronENST00000527411ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-intronENST00000527411ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-intronENST00000527659ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-intronENST00000527659ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-intronENST00000527659ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-intronENST00000527659ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-intronENST00000528282ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-intronENST00000528282ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-intronENST00000528282ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-intronENST00000528282ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-intronENST00000529208ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-intronENST00000529208ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-intronENST00000529208ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-intronENST00000529208ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-intronENST00000530148ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-intronENST00000530148ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-intronENST00000530148ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-intronENST00000530148ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-intronENST00000530481ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-intronENST00000530481ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-intronENST00000530481ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-intronENST00000530757ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-intronENST00000530757ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-intronENST00000530757ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-intronENST00000530757ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-
intron-intronENST00000531410ENST00000590776EPB41L2chr6

131384282

-STAT3chr17

40474512

-
intron-intronENST00000531410ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40469242

-
intron-intronENST00000531410ENST00000590776EPB41L2chr6

131384295

-STAT3chr17

40474512

-
intron-intronENST00000531410ENST00000590776EPB41L2chr6

131384294

-STAT3chr17

40474512

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for EPB41L2-STAT3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for EPB41L2-STAT3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:131384295/:40474512)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPB41L2

O43491

.
FUNCTION: Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for EPB41L2-STAT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for EPB41L2-STAT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for EPB41L2-STAT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for EPB41L2-STAT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEPB41L2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC4721531HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT7GENOMICS_ENGLAND;UNIPROT
TgeneC0018800Cardiomegaly3CTD_human
TgeneC0021368Inflammation3CTD_human
TgeneC0033578Prostatic Neoplasms3CTD_human
TgeneC0376358Malignant neoplasm of prostate3CTD_human
TgeneC1383860Cardiac Hypertrophy3CTD_human
TgeneC2936739Hyper-Immunoglobulin E Syndrome, Autosomal Dominant3CTD_human;ORPHANET
TgeneC3887645Job Syndrome3CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC4014795AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 13CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0001418Adenocarcinoma2CTD_human
TgeneC0003865Arthritis, Adjuvant-Induced2CTD_human
TgeneC0007137Squamous cell carcinoma2CTD_human
TgeneC0009324Ulcerative Colitis2CTD_human
TgeneC0019207Hepatoma, Morris2CTD_human
TgeneC0019208Hepatoma, Novikoff2CTD_human
TgeneC0023904Liver Neoplasms, Experimental2CTD_human
TgeneC0027627Neoplasm Metastasis2CTD_human
TgeneC0030297Pancreatic Neoplasm2CTD_human
TgeneC0033141Cardiomyopathies, Primary2CTD_human
TgeneC0036529Myocardial Diseases, Secondary2CTD_human
TgeneC0086404Experimental Hepatoma2CTD_human
TgeneC0205641Adenocarcinoma, Basal Cell2CTD_human
TgeneC0205642Adenocarcinoma, Oxyphilic2CTD_human
TgeneC0205643Carcinoma, Cribriform2CTD_human
TgeneC0205644Carcinoma, Granular Cell2CTD_human
TgeneC0205645Adenocarcinoma, Tubular2CTD_human
TgeneC0346647Malignant neoplasm of pancreas2CTD_human
TgeneC0878544Cardiomyopathies2CTD_human
TgeneC0971858Arthritis, Collagen-Induced2CTD_human
TgeneC0993582Arthritis, Experimental2CTD_human
TgeneC1955861T-Cell Large Granular Lymphocyte Leukemia2CGI;ORPHANET
TgeneC2930809Neutropenia and hyperlymphocytosis with large granular lymphocytes2ORPHANET
TgeneC3489795Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant2CTD_human;ORPHANET
TgeneC0004153Atherosclerosis1CTD_human
TgeneC0004364Autoimmune Diseases1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0007102Malignant tumor of colon1CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0007621Neoplastic Cell Transformation1CTD_human
TgeneC0007786Brain Ischemia1CTD_human
TgeneC0007873Uterine Cervical Neoplasm1CTD_human
TgeneC0009375Colonic Neoplasms1CTD_human
TgeneC0011581Depressive disorder1PSYGENET
TgeneC0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
TgeneC0015967Fever1CTD_human
TgeneC0016059Fibrosis1CTD_human
TgeneC0019189Hepatitis, Chronic1CTD_human
TgeneC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneC0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneC0023487Acute Promyelocytic Leukemia1ORPHANET
TgeneC0023492Leukemia, T-Cell1CTD_human
TgeneC0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
TgeneC0023903Liver neoplasms1CTD_human
TgeneC0024232Lymphatic Metastasis1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0025149Medulloblastoma1CTD_human
TgeneC0025261Memory Disorders1CTD_human
TgeneC0026998Acute Myeloid Leukemia, M11CTD_human
TgeneC0027659Neoplasms, Experimental1CTD_human
TgeneC0030246Pustulosis of Palms and Soles1CTD_human
TgeneC0032927Precancerous Conditions1CTD_human
TgeneC0033860Psoriasis1CTD_human
TgeneC0034069Pulmonary Fibrosis1CTD_human
TgeneC0035126Reperfusion Injury1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0079772T-Cell Lymphoma1CTD_human
TgeneC0087031Juvenile-Onset Still Disease1CTD_human
TgeneC0149519Chronic Persistent Hepatitis1CTD_human
TgeneC0158981Neonatal diabetes mellitus1GENOMICS_ENGLAND
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0205734Diabetes, Autoimmune1CTD_human
TgeneC0205833Medullomyoblastoma1CTD_human
TgeneC0206180Ki-1+ Anaplastic Large Cell Lymphoma1CTD_human
TgeneC0233794Memory impairment1CTD_human
TgeneC0235833Congenital diaphragmatic hernia1CTD_human
TgeneC0238281Middle Cerebral Artery Syndrome1CTD_human
TgeneC0265699Congenital hernia of foramen of Morgagni1CTD_human
TgeneC0265700Congenital hernia of foramen of Bochdalek1CTD_human
TgeneC0278510Childhood Medulloblastoma1CTD_human
TgeneC0278876Adult Medulloblastoma1CTD_human
TgeneC0282313Condition, Preneoplastic1CTD_human
TgeneC0333641Atrophic1CTD_human
TgeneC0342302Brittle diabetes1CTD_human
TgeneC0345904Malignant neoplasm of liver1CTD_human
TgeneC0520463Chronic active hepatitis1CTD_human
TgeneC0524611Cryptogenic Chronic Hepatitis1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0740376Middle Cerebral Artery Thrombosis1CTD_human
TgeneC0740391Middle Cerebral Artery Occlusion1CTD_human
TgeneC0740392Infarction, Middle Cerebral Artery1CTD_human
TgeneC0751291Desmoplastic Medulloblastoma1CTD_human
TgeneC0751292Age-Related Memory Disorders1CTD_human
TgeneC0751293Memory Disorder, Semantic1CTD_human
TgeneC0751294Memory Disorder, Spatial1CTD_human
TgeneC0751295Memory Loss1CTD_human
TgeneC0751845Middle Cerebral Artery Embolus1CTD_human
TgeneC0751846Left Middle Cerebral Artery Infarction1CTD_human
TgeneC0751847Embolic Infarction, Middle Cerebral Artery1CTD_human
TgeneC0751848Thrombotic Infarction, Middle Cerebral Artery1CTD_human
TgeneC0751849Right Middle Cerebral Artery Infarction1CTD_human
TgeneC0917798Cerebral Ischemia1CTD_human
TgeneC0919267ovarian neoplasm1CTD_human
TgeneC1140680Malignant neoplasm of ovary1CTD_human
TgeneC1168401Squamous cell carcinoma of the head and neck1CTD_human
TgeneC1257925Mammary Carcinoma, Animal1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1275668Melanotic medulloblastoma1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1512709Chronic Lymphoproliferative Disorder of NK-Cells1ORPHANET
TgeneC1563937Atherogenesis1CTD_human
TgeneC1623038Cirrhosis1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC1800706Idiopathic Pulmonary Fibrosis1CTD_human
TgeneC1833104DIABETES MELLITUS, PERMANENT NEONATAL1ORPHANET
TgeneC1876165Copper-Overload Cirrhosis1CTD_human
TgeneC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneC1968689Hyper-Immunoglobulin E Syndrome, Autosomal Recessive1CTD_human
TgeneC3495559Juvenile arthritis1CTD_human
TgeneC3714758Juvenile psoriatic arthritis1CTD_human
TgeneC3837958Diabetes Mellitus, Ketosis-Prone1CTD_human
TgeneC4048328cervical cancer1CTD_human
TgeneC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneC4554117Diabetes Mellitus, Sudden-Onset1CTD_human
TgeneC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human
TgeneC4721507Alveolitis, Fibrosing1CTD_human
TgeneC4721508Hamman-Rich Disease1CTD_human
TgeneC4721509Usual Interstitial Pneumonia1CTD_human
TgeneC4721952Familial Idiopathic Pulmonary Fibrosis1CTD_human