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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ERCC6-PREX1 (FusionGDB2 ID:HG2074TG57580)

Fusion Gene Summary for ERCC6-PREX1

check button Fusion gene summary
Fusion gene informationFusion gene name: ERCC6-PREX1
Fusion gene ID: hg2074tg57580
HgeneTgene
Gene symbol

ERCC6

PREX1

Gene ID

2074

57580

Gene nameERCC excision repair 6, chromatin remodeling factorphosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
SynonymsARMD5|CKN2|COFS|COFS1|CSB|CSB-PGBD3|POF11|RAD26|UVSS1P-REX1
Cytomap('ERCC6')('PREX1')

10q11.23

20q13.13

Type of geneprotein-codingprotein-coding
DescriptionDNA excision repair protein ERCC-6ERCC6-PGBD3 fusion proteinATP-dependent helicase ERCC6Chimeric CSB-PGBD3 proteinChimeric ERCC6-PGBD3 proteinCockayne syndrome group B proteincockayne syndrome protein CSBexcision repair cross-complementation group phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 proteinPIP3 dependent Rac exchange factor 1ptdIns(3,4,5)-dependent Rac exchanger 1
Modification date2020032220200313
UniProtAcc

P0DP91

.
Ensembl transtripts involved in fusion geneENST00000355832, ENST00000465653, 
ENST00000542458, 
Fusion gene scores* DoF score6 X 7 X 3=1266 X 7 X 3=126
# samples 78
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERCC6 [Title/Abstract] AND PREX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERCC6(50736463)-PREX1(47324959), # samples:2
Anticipated loss of major functional domain due to fusion event.ERCC6-PREX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERCC6-PREX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERCC6-PREX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERCC6-PREX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERCC6

GO:0000012

single strand break repair

29545921

HgeneERCC6

GO:0006979

response to oxidative stress

16107709

HgeneERCC6

GO:0009411

response to UV

16916636

HgeneERCC6

GO:0032784

regulation of DNA-templated transcription, elongation

9326587

HgeneERCC6

GO:0032786

positive regulation of DNA-templated transcription, elongation

9326587

HgeneERCC6

GO:0097680

double-strand break repair via classical nonhomologous end joining

29545921


check buttonFusion gene breakpoints across ERCC6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PREX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A2KD-01AERCC6chr10

50736463

-PREX1chr20

47324959

-
ChimerDB4BRCATCGA-A7-A2KDERCC6chr10

50736462

-PREX1chr20

47324959

-


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Fusion Gene ORF analysis for ERCC6-PREX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000355832ENST00000496915ERCC6chr10

50736463

-PREX1chr20

47324959

-
5CDS-intronENST00000355832ENST00000496915ERCC6chr10

50736462

-PREX1chr20

47324959

-
In-frameENST00000355832ENST00000371941ERCC6chr10

50736463

-PREX1chr20

47324959

-
In-frameENST00000355832ENST00000371941ERCC6chr10

50736462

-PREX1chr20

47324959

-
In-frameENST00000355832ENST00000396220ERCC6chr10

50736463

-PREX1chr20

47324959

-
In-frameENST00000355832ENST00000396220ERCC6chr10

50736462

-PREX1chr20

47324959

-
intron-3CDSENST00000465653ENST00000371941ERCC6chr10

50736463

-PREX1chr20

47324959

-
intron-3CDSENST00000465653ENST00000371941ERCC6chr10

50736462

-PREX1chr20

47324959

-
intron-3CDSENST00000465653ENST00000396220ERCC6chr10

50736463

-PREX1chr20

47324959

-
intron-3CDSENST00000465653ENST00000396220ERCC6chr10

50736462

-PREX1chr20

47324959

-
intron-3CDSENST00000542458ENST00000371941ERCC6chr10

50736463

-PREX1chr20

47324959

-
intron-3CDSENST00000542458ENST00000371941ERCC6chr10

50736462

-PREX1chr20

47324959

-
intron-3CDSENST00000542458ENST00000396220ERCC6chr10

50736463

-PREX1chr20

47324959

-
intron-3CDSENST00000542458ENST00000396220ERCC6chr10

50736462

-PREX1chr20

47324959

-
intron-intronENST00000465653ENST00000496915ERCC6chr10

50736463

-PREX1chr20

47324959

-
intron-intronENST00000465653ENST00000496915ERCC6chr10

50736462

-PREX1chr20

47324959

-
intron-intronENST00000542458ENST00000496915ERCC6chr10

50736463

-PREX1chr20

47324959

-
intron-intronENST00000542458ENST00000496915ERCC6chr10

50736462

-PREX1chr20

47324959

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355832ERCC6chr1050736463-ENST00000371941PREX1chr2047324959-672373172550891454
ENST00000355832ERCC6chr1050736463-ENST00000396220PREX1chr2047324959-682473172547951356
ENST00000355832ERCC6chr1050736462-ENST00000371941PREX1chr2047324959-672373172550891454
ENST00000355832ERCC6chr1050736462-ENST00000396220PREX1chr2047324959-682473172547951356

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355832ENST00000371941ERCC6chr1050736463-PREX1chr2047324959-0.0058817270.99411833
ENST00000355832ENST00000396220ERCC6chr1050736463-PREX1chr2047324959-0.003317770.9966822
ENST00000355832ENST00000371941ERCC6chr1050736462-PREX1chr2047324959-0.0058817270.99411833
ENST00000355832ENST00000396220ERCC6chr1050736462-PREX1chr2047324959-0.003317770.9966822

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Fusion Genomic Features for ERCC6-PREX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ERCC6-PREX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:50736463/chr20:47324959)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERCC6

P0DP91

.
FUNCTION: Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses. This response is almost completely suppressed in the presence of ERCC6. In the presence of ERCC6, regulates the expression of genes involved in metabolism regulation, including IGFBP5 and IGFBP7. In vitro binds to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF. {ECO:0000269|PubMed:22483866}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePREX1chr10:50736462chr20:47324959ENST00000371941440271_3922071660.0DomainPH
TgenePREX1chr10:50736462chr20:47324959ENST00000371941440421_4962071660.0DomainDEP 1
TgenePREX1chr10:50736462chr20:47324959ENST00000371941440523_5972071660.0DomainDEP 2
TgenePREX1chr10:50736462chr20:47324959ENST00000371941440625_7032071660.0DomainPDZ
TgenePREX1chr10:50736462chr20:47324959ENST00000396220439271_3922072042.0DomainPH
TgenePREX1chr10:50736462chr20:47324959ENST00000396220439421_4962072042.0DomainDEP 1
TgenePREX1chr10:50736462chr20:47324959ENST00000396220439523_5972072042.0DomainDEP 2
TgenePREX1chr10:50736462chr20:47324959ENST00000396220439625_7032072042.0DomainPDZ
TgenePREX1chr10:50736463chr20:47324959ENST00000371941440271_3922071660.0DomainPH
TgenePREX1chr10:50736463chr20:47324959ENST00000371941440421_4962071660.0DomainDEP 1
TgenePREX1chr10:50736463chr20:47324959ENST00000371941440523_5972071660.0DomainDEP 2
TgenePREX1chr10:50736463chr20:47324959ENST00000371941440625_7032071660.0DomainPDZ
TgenePREX1chr10:50736463chr20:47324959ENST00000396220439271_3922072042.0DomainPH
TgenePREX1chr10:50736463chr20:47324959ENST00000396220439421_4962072042.0DomainDEP 1
TgenePREX1chr10:50736463chr20:47324959ENST00000396220439523_5972072042.0DomainDEP 2
TgenePREX1chr10:50736463chr20:47324959ENST00000396220439625_7032072042.0DomainPDZ

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERCC6chr10:50736462chr20:47324959ENST00000355832-421356_3942171494.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneERCC6chr10:50736462chr20:47324959ENST00000355832-421442_4462171494.0Compositional biasNote=Gly-rich
HgeneERCC6chr10:50736463chr20:47324959ENST00000355832-421356_3942171494.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneERCC6chr10:50736463chr20:47324959ENST00000355832-421442_4462171494.0Compositional biasNote=Gly-rich
HgeneERCC6chr10:50736462chr20:47324959ENST00000355832-421519_6952171494.0DomainHelicase ATP-binding
HgeneERCC6chr10:50736462chr20:47324959ENST00000355832-421843_10022171494.0DomainHelicase C-terminal
HgeneERCC6chr10:50736463chr20:47324959ENST00000355832-421519_6952171494.0DomainHelicase ATP-binding
HgeneERCC6chr10:50736463chr20:47324959ENST00000355832-421843_10022171494.0DomainHelicase C-terminal
HgeneERCC6chr10:50736462chr20:47324959ENST00000355832-421646_6492171494.0MotifDEAH box
HgeneERCC6chr10:50736463chr20:47324959ENST00000355832-421646_6492171494.0MotifDEAH box
HgeneERCC6chr10:50736462chr20:47324959ENST00000355832-421532_5392171494.0Nucleotide bindingATP
HgeneERCC6chr10:50736463chr20:47324959ENST00000355832-421532_5392171494.0Nucleotide bindingATP
HgeneERCC6chr10:50736462chr20:47324959ENST00000355832-4211400_14282171494.0RegionUbiquitin-binding domain (UBD)
HgeneERCC6chr10:50736462chr20:47324959ENST00000355832-4211429_14932171494.0RegionWinged-helix domain (WHD)
HgeneERCC6chr10:50736462chr20:47324959ENST00000355832-4211_5102171494.0RegionN-terminal domain%3B essential for its chromatin remodeling activity
HgeneERCC6chr10:50736463chr20:47324959ENST00000355832-4211400_14282171494.0RegionUbiquitin-binding domain (UBD)
HgeneERCC6chr10:50736463chr20:47324959ENST00000355832-4211429_14932171494.0RegionWinged-helix domain (WHD)
HgeneERCC6chr10:50736463chr20:47324959ENST00000355832-4211_5102171494.0RegionN-terminal domain%3B essential for its chromatin remodeling activity
TgenePREX1chr10:50736462chr20:47324959ENST0000037194144049_2402071660.0DomainDH
TgenePREX1chr10:50736462chr20:47324959ENST0000039622043949_2402072042.0DomainDH
TgenePREX1chr10:50736463chr20:47324959ENST0000037194144049_2402071660.0DomainDH
TgenePREX1chr10:50736463chr20:47324959ENST0000039622043949_2402072042.0DomainDH


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Fusion Gene Sequence for ERCC6-PREX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27328_27328_1_ERCC6-PREX1_ERCC6_chr10_50736462_ENST00000355832_PREX1_chr20_47324959_ENST00000371941_length(transcript)=6723nt_BP=731nt
TGGGTTCCAAGGCGGCTGGCGGCGGTAGCGTCTCTGTTTCCTTGTGGGCGCTCGCGCGGCCCTGGGTAGTCTGTAGAGAATGCCAAATGA
GGGAATCCCCCACTCAAGTCAAACTCAGGAGCAAGACTGTTTACAGAGTCAACCTGTCAGTAATAATGAAGAAATGGCAATCAAGCAAGA
AAGTGGTGGTGATGGGGAGGTGGAGGAGTACCTCTCCTTTCGTTCTGTGGGTGACGGGCTGTCCACCTCTGCTGTGGGGTGCGCATCAGC
AGCTCCGAGGAGAGGGCCAGCCCTGCTGCACATCGACCGACATCAGATCCAGGCAGTAGAGCCTAGCGCCCAGGCCCTTGAGCTGCAGGG
TTTGGGTGTGGACGTCTATGACCAGGACGTGCTGGAACAGGGAGTGCTTCAGCAGGTGGACAATGCCATCCATGAGGCCAGCCGTGCCTC
CCAGCTCGTTGACGTGGAGAAGGAGTATCGGTCGGTCCTGGATGACCTCACGTCATGTACGACATCCCTAAGGCAAATCAATAAAATTAT
TGAACAGCTTAGCCCTCAAGCTGCCACCAGCAGAGACATCAACAGGAAACTAGATTCTGTAAAACGACAGAAGTATAATAAGGAACAACA
GCTAAAAAAGATCACTGCAAAACAAAAGCATCTCCAGGCCATCCTTGGAGGAGCAGAGGTGAAAATTGAACTAGATCACGCCAGTCTGGA
GGAGGATGCAGGAGCTGGCCAAGAGGACTCCCGGCAAGCACCCAGACCACCCCGCGGTCCAGAGTGCCCTGCAGGCCATGAAGACCGTTT
GCTCCAACATCAATGAGACCAAGCGGCAGATGGAGAAGCTGGAAGCCCTGGAGCAGCTGCAGTCCCACATCGAAGGCTGGGAGGGTTCCA
ACCTCACAGACATCTGCACTCAGCTCCTCCTGCAAGGGACTTTGTTAAAGATCTCTGCGGGCAACATCCAGGAAAGGGCCTTCTTCCTCT
TCGACAACCTTCTCGTCTACTGCAAGCGGAAATCCAGGGTCACCGGGAGCAAGAAGTCCACCAAGAGGACCAAATCCATCAACGGCTCCC
TCTACATCTTCAGGGGTCGAATCAACACTGAAGTCATGGAGGTGGAGAATGTGGAAGATGGGACAGCGGATTACCATAGCAACGGCTATA
CCGTCACCAACGGCTGGAAGATCCACAACACGGCCAAGAATAAGTGGTTTGTCTGCATGGCCAAGACGGCAGAGGAGAAGCAGAAGTGGC
TGGATGCCATCATCCGCGAGCGGGAGCAGCGCGAGAGCCTGAAGCTGGGCATGGAGCGTGATGCCTACGTCATGATTGCGGAGAAGGGGG
AGAAGCTGTACCACATGATGATGAACAAGAAGGTGAACCTCATCAAGGACCGCCGGAGAAAGCTGAGCACTGTCCCCAAGTGCTTTCTTG
GCAATGAGTTCGTTGCCTGGCTCCTAGAAATTGGTGAAATCAGCAAGACGGAAGAAGGAGTCAACTTGGGCCAAGCCCTGTTGGAGAATG
GCATCATCCACCATGTTTCCGACAAGCACCAGTTCAAGAATGAGCAGGTGATGTATCGCTTCCGCTACGACGATGGCACCTACAAGGCCC
GAAGTGAGCTGGAGGACATCATGTCCAAGGGTGTGAGGCTTTACTGCCGTCTTCACAGCCTCTACACCCCGGTGATCAAAGACCGTGATT
ACCACCTGAAGACCTACAAGTCAGTGCTTCCCGGGAGCAAGCTGGTGGACTGGCTGCTGGCTCAGGGAGACTGCCAGACTCGGGAGGAGG
CAGTGGCGCTCGGCGTGGGTCTGTGCAACAATGGCTTCATGCACCACGTGCTGGAGAAGAGCGAGTTCAGGGATGAGTCCCAGTACTTCC
GCTTTCATGCTGACGAGGAGATGGAGGGGACCAGCAGCAAGAACAAACAGCTTCGCAACGACTTCAAGCTGGTGGAGAACATTCTGGCCA
AGCGCCTGCTGATCCTGCCCCAGGAGGAGGACTATGGCTTTGACATCGAGGAGAAGAACAAGGCTGTGGTGGTGAAGTCCGTCCAGAGGG
GCTCGCTGGCTGAGGTGGCTGGCCTGCAGGTGGGGAGGAAGATCTACTCCATCAATGAGGACCTGGTGTTCCTGCGGCCGTTTTCAGAGG
TGGAGTCCATCCTCAACCAGTCCTTCTGCTCCCGCCGCCCTCTGCGCCTCCTGGTGGCCACGAAGGCCAAAGAGATCATCAAAATCCCCG
ACCAGCCGGACACACTGTGCTTCCAGATTCGTGGAGCTGCCCCACCGTACGTCTATGCTGTGGGGAGAGGCTCTGAGGCCATGGCTGCAG
GGCTCTGTGCTGGTCAGTGCATTCTGAAGGTCAATGGCAGCAACGTGATGAACGATGGTGCCCCTGAGGTCCTGGAGCACTTCCAGGCAT
TCCGGAGTCGGCGCGAAGAGGCCCTGGGCCTGTACCAGTGGATCTACCACACCCATGAGGATGCCCAGGAAGCACGAGCCAGTCAGGAGG
CCTCCACTGAGGACCCCAGTGGCGAGCAGGCCCAGGAGGAAGACCAGGCTGATTCAGCCTTCCCACTGCTGTCCCTGGGTCCCCGGCTGA
GCCTGTGTGAGGACAGCCCCATGGTCACCCTGACTGTGGACAACGTGCACCTGGAACACGGCGTGGTGTATGAGTATGTGAGCACGGCAG
GCGTCAGGTGCCATGTGCTGGAGAAGATCGTGGAGCCCCGCGGCTGCTTCGGCCTCACCGCCAAGATCCTCGAGGCCTTTGCTGCCAATG
ACAGCGTCTTCGTGGAGAACTGCAGGCGGCTCATGGCCCTGAGCAGCGCCATCGTGACCATGCCCCACTTTGAGTTCCGCAACATCTGTG
ACACCAAGCTGGAGAGCATTGGCCAGAGGATTGCCTGCTACCAGGAGTTTGCAGCCCAACTGAAGAGCAGGGTCAGCCCACCCTTCAAAC
AAGCCCCCCTGGAGCCCCACCCGCTGTGTGGCCTGGACTTCTGCCCCACCAATTGCCACATCAACCTCATGGAAGTGTCCTACCCCAAGA
CCACCCCCTCAGTGGGCAGGTCCTTCAGCATCCGCTTTGGACGCAAACCCTCCCTCATCGGCCTTGACCCGGAGCAAGGCCACCTGAACC
CCATGTCGTACACCCAGCACTGCATCACCACCATGGCTGCTCCCTCCTGGAAGTGCTTGCCTGCTGCAGAGGGTGATCCCCAAGGCCAGG
GTCTCCATGATGGCAGCTTCGGGCCAGCCAGTGGGACCCTTGGTCAGGAAGACCGGGGCCTCAGCTTCCTACTCAAGCAGGAGGACCGTG
AGATCCAGGATGCCTACCTGCAGCTCTTCACCAAGCTGGATGTGGCCCTGAAGGAGATGAAGCAATATGTCACCCAGATCAACAGGCTGC
TGTCCACCATCACAGAGCCCACCTCGGGTGGGTCCTGCGACGCATCCTTGGCTGAGGAGGCCTCCTCCCTGCCCCTGGTCAGTGAAGAGA
GCGAGATGGACAGGAGTGACCATGGGGGCATCAAGAAGGTGTGCTTCAAGGTGGCCGAGGAGGACCAGGAGGACTCAGGCCACGACACCA
TGAGTTATCGCGACTCCTACAGCGAGTGTAACAGCAATCGAGACTCGGTCCTGTCCTACACCAGCGTGAGAAGTAACAGCTCCTACTTGG
GCAGCGACGAGATGGGGTCTGGAGATGAGCTGCCCTGTGACATGCGGATCCCATCTGACAAGCAGGACAAGCTTCATGGCTGCCTGGAGC
ACCTCTTTAACCAGGTGGACTCCATCAATGCTCTCCTCAAGGGGCCAGTCATGAGCCGGGCTTTCGAAGAGACCAAGCATTTCCCTATGA
ACCACAGCTTACAAGAGTTTAAACAGAAAGAAGAGTGTACAATCCGTGGCCGGAGCCTGATCCAGATTAGCATCCAGGAGGACCCCTGGA
ACCTCCCCAACTCCATCAAGACCCTGGTGGACAACATTCAGAGATATGTGGAAGATGGGAAGAACCAGCTGCTCCTGGCCTTGCTGAAGT
GCACAGACACGGAGCTGCAGCTGCGCAGAGACGCGATCTTCTGCCAGGCCCTGGTGGCCGCCGTGTGCACCTTCTCCAAGCAGCTGCTGG
CGGCCCTGGGCTACCGCTACAACAACAATGGCGAGTACGAGGAGAGCAGCCGCGACGCCAGCCGCAAGTGGCTGGAGCAGGTGGCGGCCA
CGGGCGTCCTGCTGCACTGCCAGTCCCTGCTCTCGCCAGCCACAGTGAAGGAGGAACGGACCATGCTGGAGGACATCTGGGTGACGCTGT
CAGAGCTGGACAATGTCACCTTCTCCTTTAAGCAGCTGGACGAGAACTATGTGGCCAACACCAACGTCTTCTACCACATTGAGGGCAGCC
GGCAGGCGCTGAAGGTCATCTTCTACCTCGACAGCTACCACTTCTCCAAGCTGCCCTCCCGCCTGGAGGGTGGGGCCAGCCTGAGGCTGC
ACACAGCGCTGTTCACGAAAGTGCTGGAGAACGTGGAGGGGCTGCCTTCTCCAGGCAGCCAGGCCGCGGAGGATTTGCAGCAGGACATCA
ACGCGCAGTCCCTGGAGAAAGTTCAGCAGTATTACCGCAAACTCAGGGCATTTTACCTGGAGCGGTCTAACCTGCCCACGGATGCCAGCA
CCACGGCGGTAAAGATAGACCAGCTGATCCGCCCCATCAATGCCCTGGATGAGCTCTGCCGCCTCATGAAGTCCTTTGTCCACCCAAAGC
CTGGTGCTGCTGGGAGTGTGGGCGCCGGCCTCATCCCCATCTCCTCGGAGCTCTGCTACCGCCTGGGGGCCTGCCAGATGGTCATGTGTG
GCACAGGCATGCAGAGGAGCACCCTGAGCGTGTCCCTGGAGCAGGCGGCCATCTTGGCACGGAGCCACGGGTTGCTGCCCAAGTGCATCA
TGCAGGCCACGGACATCATGCGGAAGCAGGGCCCAAGGGTGGAGATTCTGGCCAAAAACCTGCGAGTCAAGGACCAGATGCCCCAGGGTG
CTCCGCGCCTCTACCGCCTCTGCCAGCCGCCGGTGGATGGGGACCTCTGAACACCCAAATGCCCCACGCTGGGCCGCGGCCTCTGGAGCT
GGGATTTGGGAGGACACAGCAGGCAGCGCTGGCCTTCTCCAGGGATGGCCCAAGGCTTCCGCAGCCGCCCGTTCCGGGACCTGCCCAGCG
TCCTCCCTGCCTCCTTCCGGGACAAGCCTGGCCACCCTCGCTGTGATGACGAGCTGGCTGATTGGCCCTGGGCCGGCCCATTCTTCACAC
GCCTGCCAGAAGCTGGAGGGGTGCTGGAGACCCATAGAGCTGATGGGAGCAGCTGGTGCCTGGCCTTCGGCTCCTGCGTCCCCAGAACCC
AAGGGAACGTCATGGAGGCCACATGGGGCCACCCGGCTCCCTCGGGATGGCTCCGCCTGCACTTTTGAAACCCCGGTTTCCTTCAACGTC
CACATTCCAGGTGACCACACGTGTCTCCTCCTCCTCATCTTAGCTTCCAGGTTCACCCTAACCCTGTACTAACCTGCTTGGTGGACTTGG
AAAAGACTTGGCTCTGTCGGGAAAGGAGAGACGGGGCCTCCATCACGCCTGTTACCAGAGGATCCCCGAGAGCCACACCAGCTCTGGACA
TCACCGCCCCTGGAACTGGGGCCACCAGCCCTGGGCACGAGATTTGCTCTGACTTTATTTATATGGCATGAAATCTCTGGTTTATTTTGG
GATTTTTTGTTGTTGGTGTTGTCAAAGTTTGTTTTTTCTAAAGTTGTGTGATTATATATTTGACATTTTACATTTCAAAGAAAGGTATGT
TGTCTAACAGGGGACCAACAGAAGGTAGTATTGACAACTGTTCCTGCTTCTACTAAAAAAAAAAGAGCACAAAAGAAAAACTAAATTATT
GAAAAATTAAAAAATGTCATTGTTTCCTGTTTGTTAATATTAGGGTTGTAAGGTGTCGTTTTGAGGTATCGACTGTGATTCCTTCCCCCA
CCCTCCATTCTCCAGCGGTTGGCCGGTGTTAGAACTCGCTCTCTTTGAGTGACTGGCTACAAGGGCCTGAGAGGTGGCCAGCCAGGGTTG
GAGCTGGAGGGGATGGAGCCCCACCTGAGGTGCCGTGTCACACGGGTTAGAGGGTCACTGGGAAACACCGGGCGGTGGCTTCTGTGATTT
ATTTTCTTGATGGTAACTTCTCAGAGCAGGGCGATTGGGACATCACCAGCCAGAGCACAGGAAGCCACCCTGCCTGCTGGGGAGGAGGGA
CCCACACAAGCCCCCTCGGCAGTTTGTCCCCCCAGCTTCGGTATGCCTTCAGGGAAAGGTCACAGCTGGGGAGGAAGCGGGGGGACGCCT
GTCACCCCTGGCAGGTGGTGAGTTCAGGTGGGGGCTCCCTGCTGCCCCCAGGCCTGGGAGCTTGAAGCCCTCCCGGCATCTGGCATCCGA
GCCTCCCGCCCTCCAGGGTGCGCTTCCCTCTCTTGCCGCAGCATACACGAGGGCAGGCAGTGGCCTTGTCACTGTATCTTGCATCAGAGA
CAAAGGAGGACCCGCTTTAGCCCTGCTGCGGGAAATGGGGGAGGGCCCAGGGCCAGCGCATTGTGCACTGGTTTACTTTAAAATGTACAG

>27328_27328_1_ERCC6-PREX1_ERCC6_chr10_50736462_ENST00000355832_PREX1_chr20_47324959_ENST00000371941_length(amino acids)=1454AA_BP=1
MQELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFD
NLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLD
AIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGI
IHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAV
ALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGS
LAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGL
CAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSL
CEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDT
KLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPM
SYTQHCITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLS
TITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGS
DEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDPWNL
PNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSKQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATG
VLLHCQSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLRLHT
ALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPG
AAGSVGAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQMPQGAP

--------------------------------------------------------------
>27328_27328_2_ERCC6-PREX1_ERCC6_chr10_50736462_ENST00000355832_PREX1_chr20_47324959_ENST00000396220_length(transcript)=6824nt_BP=731nt
TGGGTTCCAAGGCGGCTGGCGGCGGTAGCGTCTCTGTTTCCTTGTGGGCGCTCGCGCGGCCCTGGGTAGTCTGTAGAGAATGCCAAATGA
GGGAATCCCCCACTCAAGTCAAACTCAGGAGCAAGACTGTTTACAGAGTCAACCTGTCAGTAATAATGAAGAAATGGCAATCAAGCAAGA
AAGTGGTGGTGATGGGGAGGTGGAGGAGTACCTCTCCTTTCGTTCTGTGGGTGACGGGCTGTCCACCTCTGCTGTGGGGTGCGCATCAGC
AGCTCCGAGGAGAGGGCCAGCCCTGCTGCACATCGACCGACATCAGATCCAGGCAGTAGAGCCTAGCGCCCAGGCCCTTGAGCTGCAGGG
TTTGGGTGTGGACGTCTATGACCAGGACGTGCTGGAACAGGGAGTGCTTCAGCAGGTGGACAATGCCATCCATGAGGCCAGCCGTGCCTC
CCAGCTCGTTGACGTGGAGAAGGAGTATCGGTCGGTCCTGGATGACCTCACGTCATGTACGACATCCCTAAGGCAAATCAATAAAATTAT
TGAACAGCTTAGCCCTCAAGCTGCCACCAGCAGAGACATCAACAGGAAACTAGATTCTGTAAAACGACAGAAGTATAATAAGGAACAACA
GCTAAAAAAGATCACTGCAAAACAAAAGCATCTCCAGGCCATCCTTGGAGGAGCAGAGGTGAAAATTGAACTAGATCACGCCAGTCTGGA
GGAGGATGCAGGAGCTGGCCAAGAGGACTCCCGGCAAGCACCCAGACCACCCCGCGGTCCAGAGTGCCCTGCAGGCCATGAAGACCGTTT
GCTCCAACATCAATGAGACCAAGCGGCAGATGGAGAAGCTGGAAGCCCTGGAGCAGCTGCAGTCCCACATCGAAGGCTGGGAGGGTTCCA
ACCTCACAGACATCTGCACTCAGCTCCTCCTGCAAGGGACTTTGTTAAAGATCTCTGCGGGCAACATCCAGGAAAGGGCCTTCTTCCTCT
TCGACAACCTTCTCGTCTACTGCAAGCGGAAATCCAGGGTCACCGGGAGCAAGAAGTCCACCAAGAGGACCAAATCCATCAACGGCTCCC
TCTACATCTTCAGGGGTCGAATCAACACTGAAGTCATGGAGGTGGAGAATGTGGAAGATGGGACAGCGGATTACCATAGCAACGGCTATA
CCGTCACCAACGGCTGGAAGATCCACAACACGGCCAAGAATAAGTGGTTTGTCTGCATGGCCAAGACGGCAGAGGAGAAGCAGAAGTGGC
TGGATGCCATCATCCGCGAGCGGGAGCAGCGCGAGAGCCTGAAGCTGGGCATGGAGCGTGATGCCTACGTCATGATTGCGGAGAAGGGGG
AGAAGCTGTACCACATGATGATGAACAAGAAGGTGAACCTCATCAAGGACCGCCGGAGAAAGCTGAGCACTGTCCCCAAGTGCTTTCTTG
GCAATGAGTTCGTTGCCTGGCTCCTAGAAATTGGTGAAATCAGCAAGACGGAAGAAGGAGTCAACTTGGGCCAAGCCCTGTTGGAGAATG
GCATCATCCACCATGTTTCCGACAAGCACCAGTTCAAGAATGAGCAGGTGATGTATCGCTTCCGCTACGACGATGGCACCTACAAGGCCC
GAAGTGAGCTGGAGGACATCATGTCCAAGGGTGTGAGGCTTTACTGCCGTCTTCACAGCCTCTACACCCCGGTGATCAAAGACCGTGATT
ACCACCTGAAGACCTACAAGTCAGTGCTTCCCGGGAGCAAGCTGGTGGACTGGCTGCTGGCTCAGGGAGACTGCCAGACTCGGGAGGAGG
CAGTGGCGCTCGGCGTGGGTCTGTGCAACAATGGCTTCATGCACCACGTGCTGGAGAAGAGCGAGTTCAGGGATGAGTCCCAGTACTTCC
GCTTTCATGCTGACGAGGAGATGGAGGGGACCAGCAGCAAGAACAAACAGCTTCGCAACGACTTCAAGCTGGTGGAGAACATTCTGGCCA
AGCGCCTGCTGATCCTGCCCCAGGAGGAGGACTATGGCTTTGACATCGAGGAGAAGAACAAGGCTGTGGTGGTGAAGTCCGTCCAGAGGG
GCTCGCTGGCTGAGGTGGCTGGCCTGCAGGTGGGGAGGAAGATCTACTCCATCAATGAGGACCTGGTGTTCCTGCGGCCGTTTTCAGAGG
TGGAGTCCATCCTCAACCAGTCCTTCTGCTCCCGCCGCCCTCTGCGCCTCCTGGTGGCCACGAAGGCCAAAGAGATCATCAAAATCCCCG
ACCAGCCGGACACACTGTGCTTCCAGATTCGTGGAGCTGCCCCACCGTACGTCTATGCTGTGGGGAGAGGCTCTGAGGCCATGGCTGCAG
GGCTCTGTGCTGGTCAGTGCATTCTGAAGGTCAATGGCAGCAACGTGATGAACGATGGTGCCCCTGAGGTCCTGGAGCACTTCCAGGCAT
TCCGGAGTCGGCGCGAAGAGGCCCTGGGCCTGTACCAGTGGATCTACCACACCCATGAGGATGCCCAGGAAGCACGAGCCAGTCAGGAGG
CCTCCACTGAGGACCCCAGTGGCGAGCAGGCCCAGGAGGAAGACCAGGCTGATTCAGCCTTCCCACTGCTGTCCCTGGGTCCCCGGCTGA
GCCTGTGTGAGGACAGCCCCATGGTCACCCTGACTGTGGACAACGTGCACCTGGAACACGGCGTGGTGTATGAGTATGTGAGCACGGCAG
GCGTCAGGTGCCATGTGCTGGAGAAGATCGTGGAGCCCCGCGGCTGCTTCGGCCTCACCGCCAAGATCCTCGAGGCCTTTGCTGCCAATG
ACAGCGTCTTCGTGGAGAACTGCAGGCGGCTCATGGCCCTGAGCAGCGCCATCGTGACCATGCCCCACTTTGAGTTCCGCAACATCTGTG
ACACCAAGCTGGAGAGCATTGGCCAGAGGATTGCCTGCTACCAGGAGTTTGCAGCCCAACTGAAGAGCAGGGTCAGCCCACCCTTCAAAC
AAGCCCCCCTGGAGCCCCACCCGCTGTGTGGCCTGGACTTCTGCCCCACCAATTGCCACATCAACCTCATGGAAGTGTCCTACCCCAAGA
CCACCCCCTCAGTGGGCAGGTCCTTCAGCATCCGCTTTGGACGCAAACCCTCCCTCATCGGCCTTGACCCGGAGCAAGGCCACCTGAACC
CCATGTCGTACACCCAGCACTGCATCACCACCATGGCTGCTCCCTCCTGGAAGTGCTTGCCTGCTGCAGAGGGTGATCCCCAAGGCCAGG
GTCTCCATGATGGCAGCTTCGGGCCAGCCAGTGGGACCCTTGGTCAGGAAGACCGGGGCCTCAGCTTCCTACTCAAGCAGGAGGACCGTG
AGATCCAGGATGCCTACCTGCAGCTCTTCACCAAGCTGGATGTGGCCCTGAAGGAGATGAAGCAATATGTCACCCAGATCAACAGGCTGC
TGTCCACCATCACAGAGCCCACCTCGGGTGGGTCCTGCGACGCATCCTTGGCTGAGGAGGCCTCCTCCCTGCCCCTGGTCAGTGAAGAGA
GCGAGATGGACAGGAGTGACCATGGGGGCATCAAGAAGGTGTGCTTCAAGGTGGCCGAGGAGGACCAGGAGGACTCAGGCCACGACACCA
TGAGTTATCGCGACTCCTACAGCGAGTGTAACAGCAATCGAGACTCGGTCCTGTCCTACACCAGCGTGAGAAGTAACAGCTCCTACTTGG
GCAGCGACGAGATGGGGTCTGGAGATGAGCTGCCCTGTGACATGCGGATCCCATCTGACAAGCAGGACAAGCTTCATGGCTGCCTGGAGC
ACCTCTTTAACCAGGTGGACTCCATCAATGCTCTCCTCAAGGGGCCAGTCATGAGCCGGGCTTTCGAAGAGACCAAGCATTTCCCTATGA
ACCACAGCTTACAAGAGTTTAAACAGAAAGAAGAGTGTACAATCCGTGGCCGGAGCCTGATCCAGATTAGCATCCAGGAGGACCCCTGGA
ACCTCCCCAACTCCATCAAGACCCTGGTGGACAACATTCAGAGATATGTGGAAGATGGGAAGAACCAGCTGCTCCTGGCCTTGCTGAAGT
GCACAGACACGGAGCTGCAGCTGCGCAGAGACGCGATCTTCTGCCAGGCCCTGGTGGCCGCCGTGTGCACCTTCTCCAAGCAGCTGCTGG
CGGCCCTGGGCTACCGCTACAACAACAATGGCGAGTACGAGGAGAGCAGCCGCGACGCCAGCCGCAAGTGGCTGGAGCAGGTGGCGGCCA
CGGGCGTCCTGCTGCACTGCCAGTCCCTGCTCTCGCCAGCCACAGTGAAGGAGGAACGGACCATGCTGGAGGACATCTGGGTGACGCTGT
CAGAGCTGGACAATGTCACCTTCTCCTTTAAGCAGCTGGACGAGAACTATGTGGCCAACACCAACGTCTTCTACCACATTGAGGGCAGCC
GGCAGGCGCTGAAGGTCATCTTCTACCTCGACAGCTACCACTTCTCCAAGCTGCCCTCCCGCCTGGAGGGTGGGGCCAGCCTGAGGCTGC
ACACAGCGCTGTTCACGAAAGGTGAGCTTCAGGCCTGGGGCAGGGAGGACCACGGGGGCCGGGCCAAGGCCACCAAGCACACCGGCTCCC
AACCGCCTGCCCGCCCCCGACATCTCCCCTCCCAGTGCTGGAGAACGTGGAGGGGCTGCCTTCTCCAGGCAGCCAGGCCGCGGAGGATTT
GCAGCAGGACATCAACGCGCAGTCCCTGGAGAAAGTTCAGCAGTATTACCGCAAACTCAGGGCATTTTACCTGGAGCGGTCTAACCTGCC
CACGGATGCCAGCACCACGGCGGTAAAGATAGACCAGCTGATCCGCCCCATCAATGCCCTGGATGAGCTCTGCCGCCTCATGAAGTCCTT
TGTCCACCCAAAGCCTGGTGCTGCTGGGAGTGTGGGCGCCGGCCTCATCCCCATCTCCTCGGAGCTCTGCTACCGCCTGGGGGCCTGCCA
GATGGTCATGTGTGGCACAGGCATGCAGAGGAGCACCCTGAGCGTGTCCCTGGAGCAGGCGGCCATCTTGGCACGGAGCCACGGGTTGCT
GCCCAAGTGCATCATGCAGGCCACGGACATCATGCGGAAGCAGGGCCCAAGGGTGGAGATTCTGGCCAAAAACCTGCGAGTCAAGGACCA
GATGCCCCAGGGTGCTCCGCGCCTCTACCGCCTCTGCCAGCCGCCGGTGGATGGGGACCTCTGAACACCCAAATGCCCCACGCTGGGCCG
CGGCCTCTGGAGCTGGGATTTGGGAGGACACAGCAGGCAGCGCTGGCCTTCTCCAGGGATGGCCCAAGGCTTCCGCAGCCGCCCGTTCCG
GGACCTGCCCAGCGTCCTCCCTGCCTCCTTCCGGGACAAGCCTGGCCACCCTCGCTGTGATGACGAGCTGGCTGATTGGCCCTGGGCCGG
CCCATTCTTCACACGCCTGCCAGAAGCTGGAGGGGTGCTGGAGACCCATAGAGCTGATGGGAGCAGCTGGTGCCTGGCCTTCGGCTCCTG
CGTCCCCAGAACCCAAGGGAACGTCATGGAGGCCACATGGGGCCACCCGGCTCCCTCGGGATGGCTCCGCCTGCACTTTTGAAACCCCGG
TTTCCTTCAACGTCCACATTCCAGGTGACCACACGTGTCTCCTCCTCCTCATCTTAGCTTCCAGGTTCACCCTAACCCTGTACTAACCTG
CTTGGTGGACTTGGAAAAGACTTGGCTCTGTCGGGAAAGGAGAGACGGGGCCTCCATCACGCCTGTTACCAGAGGATCCCCGAGAGCCAC
ACCAGCTCTGGACATCACCGCCCCTGGAACTGGGGCCACCAGCCCTGGGCACGAGATTTGCTCTGACTTTATTTATATGGCATGAAATCT
CTGGTTTATTTTGGGATTTTTTGTTGTTGGTGTTGTCAAAGTTTGTTTTTTCTAAAGTTGTGTGATTATATATTTGACATTTTACATTTC
AAAGAAAGGTATGTTGTCTAACAGGGGACCAACAGAAGGTAGTATTGACAACTGTTCCTGCTTCTACTAAAAAAAAAAGAGCACAAAAGA
AAAACTAAATTATTGAAAAATTAAAAAATGTCATTGTTTCCTGTTTGTTAATATTAGGGTTGTAAGGTGTCGTTTTGAGGTATCGACTGT
GATTCCTTCCCCCACCCTCCATTCTCCAGCGGTTGGCCGGTGTTAGAACTCGCTCTCTTTGAGTGACTGGCTACAAGGGCCTGAGAGGTG
GCCAGCCAGGGTTGGAGCTGGAGGGGATGGAGCCCCACCTGAGGTGCCGTGTCACACGGGTTAGAGGGTCACTGGGAAACACCGGGCGGT
GGCTTCTGTGATTTATTTTCTTGATGGTAACTTCTCAGAGCAGGGCGATTGGGACATCACCAGCCAGAGCACAGGAAGCCACCCTGCCTG
CTGGGGAGGAGGGACCCACACAAGCCCCCTCGGCAGTTTGTCCCCCCAGCTTCGGTATGCCTTCAGGGAAAGGTCACAGCTGGGGAGGAA
GCGGGGGGACGCCTGTCACCCCTGGCAGGTGGTGAGTTCAGGTGGGGGCTCCCTGCTGCCCCCAGGCCTGGGAGCTTGAAGCCCTCCCGG
CATCTGGCATCCGAGCCTCCCGCCCTCCAGGGTGCGCTTCCCTCTCTTGCCGCAGCATACACGAGGGCAGGCAGTGGCCTTGTCACTGTA
TCTTGCATCAGAGACAAAGGAGGACCCGCTTTAGCCCTGCTGCGGGAAATGGGGGAGGGCCCAGGGCCAGCGCATTGTGCACTGGTTTAC

>27328_27328_2_ERCC6-PREX1_ERCC6_chr10_50736462_ENST00000355832_PREX1_chr20_47324959_ENST00000396220_length(amino acids)=1356AA_BP=1
MQELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFD
NLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLD
AIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGI
IHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAV
ALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGS
LAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGL
CAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSL
CEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDT
KLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPM
SYTQHCITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLS
TITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGS
DEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDPWNL
PNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSKQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATG
VLLHCQSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLRLHT
ALFTKGELQAWGREDHGGRAKATKHTGSQPPARPRHLPSQCWRTWRGCLLQAARPRRICSRTSTRSPWRKFSSITANSGHFTWSGLTCPR

--------------------------------------------------------------
>27328_27328_3_ERCC6-PREX1_ERCC6_chr10_50736463_ENST00000355832_PREX1_chr20_47324959_ENST00000371941_length(transcript)=6723nt_BP=731nt
TGGGTTCCAAGGCGGCTGGCGGCGGTAGCGTCTCTGTTTCCTTGTGGGCGCTCGCGCGGCCCTGGGTAGTCTGTAGAGAATGCCAAATGA
GGGAATCCCCCACTCAAGTCAAACTCAGGAGCAAGACTGTTTACAGAGTCAACCTGTCAGTAATAATGAAGAAATGGCAATCAAGCAAGA
AAGTGGTGGTGATGGGGAGGTGGAGGAGTACCTCTCCTTTCGTTCTGTGGGTGACGGGCTGTCCACCTCTGCTGTGGGGTGCGCATCAGC
AGCTCCGAGGAGAGGGCCAGCCCTGCTGCACATCGACCGACATCAGATCCAGGCAGTAGAGCCTAGCGCCCAGGCCCTTGAGCTGCAGGG
TTTGGGTGTGGACGTCTATGACCAGGACGTGCTGGAACAGGGAGTGCTTCAGCAGGTGGACAATGCCATCCATGAGGCCAGCCGTGCCTC
CCAGCTCGTTGACGTGGAGAAGGAGTATCGGTCGGTCCTGGATGACCTCACGTCATGTACGACATCCCTAAGGCAAATCAATAAAATTAT
TGAACAGCTTAGCCCTCAAGCTGCCACCAGCAGAGACATCAACAGGAAACTAGATTCTGTAAAACGACAGAAGTATAATAAGGAACAACA
GCTAAAAAAGATCACTGCAAAACAAAAGCATCTCCAGGCCATCCTTGGAGGAGCAGAGGTGAAAATTGAACTAGATCACGCCAGTCTGGA
GGAGGATGCAGGAGCTGGCCAAGAGGACTCCCGGCAAGCACCCAGACCACCCCGCGGTCCAGAGTGCCCTGCAGGCCATGAAGACCGTTT
GCTCCAACATCAATGAGACCAAGCGGCAGATGGAGAAGCTGGAAGCCCTGGAGCAGCTGCAGTCCCACATCGAAGGCTGGGAGGGTTCCA
ACCTCACAGACATCTGCACTCAGCTCCTCCTGCAAGGGACTTTGTTAAAGATCTCTGCGGGCAACATCCAGGAAAGGGCCTTCTTCCTCT
TCGACAACCTTCTCGTCTACTGCAAGCGGAAATCCAGGGTCACCGGGAGCAAGAAGTCCACCAAGAGGACCAAATCCATCAACGGCTCCC
TCTACATCTTCAGGGGTCGAATCAACACTGAAGTCATGGAGGTGGAGAATGTGGAAGATGGGACAGCGGATTACCATAGCAACGGCTATA
CCGTCACCAACGGCTGGAAGATCCACAACACGGCCAAGAATAAGTGGTTTGTCTGCATGGCCAAGACGGCAGAGGAGAAGCAGAAGTGGC
TGGATGCCATCATCCGCGAGCGGGAGCAGCGCGAGAGCCTGAAGCTGGGCATGGAGCGTGATGCCTACGTCATGATTGCGGAGAAGGGGG
AGAAGCTGTACCACATGATGATGAACAAGAAGGTGAACCTCATCAAGGACCGCCGGAGAAAGCTGAGCACTGTCCCCAAGTGCTTTCTTG
GCAATGAGTTCGTTGCCTGGCTCCTAGAAATTGGTGAAATCAGCAAGACGGAAGAAGGAGTCAACTTGGGCCAAGCCCTGTTGGAGAATG
GCATCATCCACCATGTTTCCGACAAGCACCAGTTCAAGAATGAGCAGGTGATGTATCGCTTCCGCTACGACGATGGCACCTACAAGGCCC
GAAGTGAGCTGGAGGACATCATGTCCAAGGGTGTGAGGCTTTACTGCCGTCTTCACAGCCTCTACACCCCGGTGATCAAAGACCGTGATT
ACCACCTGAAGACCTACAAGTCAGTGCTTCCCGGGAGCAAGCTGGTGGACTGGCTGCTGGCTCAGGGAGACTGCCAGACTCGGGAGGAGG
CAGTGGCGCTCGGCGTGGGTCTGTGCAACAATGGCTTCATGCACCACGTGCTGGAGAAGAGCGAGTTCAGGGATGAGTCCCAGTACTTCC
GCTTTCATGCTGACGAGGAGATGGAGGGGACCAGCAGCAAGAACAAACAGCTTCGCAACGACTTCAAGCTGGTGGAGAACATTCTGGCCA
AGCGCCTGCTGATCCTGCCCCAGGAGGAGGACTATGGCTTTGACATCGAGGAGAAGAACAAGGCTGTGGTGGTGAAGTCCGTCCAGAGGG
GCTCGCTGGCTGAGGTGGCTGGCCTGCAGGTGGGGAGGAAGATCTACTCCATCAATGAGGACCTGGTGTTCCTGCGGCCGTTTTCAGAGG
TGGAGTCCATCCTCAACCAGTCCTTCTGCTCCCGCCGCCCTCTGCGCCTCCTGGTGGCCACGAAGGCCAAAGAGATCATCAAAATCCCCG
ACCAGCCGGACACACTGTGCTTCCAGATTCGTGGAGCTGCCCCACCGTACGTCTATGCTGTGGGGAGAGGCTCTGAGGCCATGGCTGCAG
GGCTCTGTGCTGGTCAGTGCATTCTGAAGGTCAATGGCAGCAACGTGATGAACGATGGTGCCCCTGAGGTCCTGGAGCACTTCCAGGCAT
TCCGGAGTCGGCGCGAAGAGGCCCTGGGCCTGTACCAGTGGATCTACCACACCCATGAGGATGCCCAGGAAGCACGAGCCAGTCAGGAGG
CCTCCACTGAGGACCCCAGTGGCGAGCAGGCCCAGGAGGAAGACCAGGCTGATTCAGCCTTCCCACTGCTGTCCCTGGGTCCCCGGCTGA
GCCTGTGTGAGGACAGCCCCATGGTCACCCTGACTGTGGACAACGTGCACCTGGAACACGGCGTGGTGTATGAGTATGTGAGCACGGCAG
GCGTCAGGTGCCATGTGCTGGAGAAGATCGTGGAGCCCCGCGGCTGCTTCGGCCTCACCGCCAAGATCCTCGAGGCCTTTGCTGCCAATG
ACAGCGTCTTCGTGGAGAACTGCAGGCGGCTCATGGCCCTGAGCAGCGCCATCGTGACCATGCCCCACTTTGAGTTCCGCAACATCTGTG
ACACCAAGCTGGAGAGCATTGGCCAGAGGATTGCCTGCTACCAGGAGTTTGCAGCCCAACTGAAGAGCAGGGTCAGCCCACCCTTCAAAC
AAGCCCCCCTGGAGCCCCACCCGCTGTGTGGCCTGGACTTCTGCCCCACCAATTGCCACATCAACCTCATGGAAGTGTCCTACCCCAAGA
CCACCCCCTCAGTGGGCAGGTCCTTCAGCATCCGCTTTGGACGCAAACCCTCCCTCATCGGCCTTGACCCGGAGCAAGGCCACCTGAACC
CCATGTCGTACACCCAGCACTGCATCACCACCATGGCTGCTCCCTCCTGGAAGTGCTTGCCTGCTGCAGAGGGTGATCCCCAAGGCCAGG
GTCTCCATGATGGCAGCTTCGGGCCAGCCAGTGGGACCCTTGGTCAGGAAGACCGGGGCCTCAGCTTCCTACTCAAGCAGGAGGACCGTG
AGATCCAGGATGCCTACCTGCAGCTCTTCACCAAGCTGGATGTGGCCCTGAAGGAGATGAAGCAATATGTCACCCAGATCAACAGGCTGC
TGTCCACCATCACAGAGCCCACCTCGGGTGGGTCCTGCGACGCATCCTTGGCTGAGGAGGCCTCCTCCCTGCCCCTGGTCAGTGAAGAGA
GCGAGATGGACAGGAGTGACCATGGGGGCATCAAGAAGGTGTGCTTCAAGGTGGCCGAGGAGGACCAGGAGGACTCAGGCCACGACACCA
TGAGTTATCGCGACTCCTACAGCGAGTGTAACAGCAATCGAGACTCGGTCCTGTCCTACACCAGCGTGAGAAGTAACAGCTCCTACTTGG
GCAGCGACGAGATGGGGTCTGGAGATGAGCTGCCCTGTGACATGCGGATCCCATCTGACAAGCAGGACAAGCTTCATGGCTGCCTGGAGC
ACCTCTTTAACCAGGTGGACTCCATCAATGCTCTCCTCAAGGGGCCAGTCATGAGCCGGGCTTTCGAAGAGACCAAGCATTTCCCTATGA
ACCACAGCTTACAAGAGTTTAAACAGAAAGAAGAGTGTACAATCCGTGGCCGGAGCCTGATCCAGATTAGCATCCAGGAGGACCCCTGGA
ACCTCCCCAACTCCATCAAGACCCTGGTGGACAACATTCAGAGATATGTGGAAGATGGGAAGAACCAGCTGCTCCTGGCCTTGCTGAAGT
GCACAGACACGGAGCTGCAGCTGCGCAGAGACGCGATCTTCTGCCAGGCCCTGGTGGCCGCCGTGTGCACCTTCTCCAAGCAGCTGCTGG
CGGCCCTGGGCTACCGCTACAACAACAATGGCGAGTACGAGGAGAGCAGCCGCGACGCCAGCCGCAAGTGGCTGGAGCAGGTGGCGGCCA
CGGGCGTCCTGCTGCACTGCCAGTCCCTGCTCTCGCCAGCCACAGTGAAGGAGGAACGGACCATGCTGGAGGACATCTGGGTGACGCTGT
CAGAGCTGGACAATGTCACCTTCTCCTTTAAGCAGCTGGACGAGAACTATGTGGCCAACACCAACGTCTTCTACCACATTGAGGGCAGCC
GGCAGGCGCTGAAGGTCATCTTCTACCTCGACAGCTACCACTTCTCCAAGCTGCCCTCCCGCCTGGAGGGTGGGGCCAGCCTGAGGCTGC
ACACAGCGCTGTTCACGAAAGTGCTGGAGAACGTGGAGGGGCTGCCTTCTCCAGGCAGCCAGGCCGCGGAGGATTTGCAGCAGGACATCA
ACGCGCAGTCCCTGGAGAAAGTTCAGCAGTATTACCGCAAACTCAGGGCATTTTACCTGGAGCGGTCTAACCTGCCCACGGATGCCAGCA
CCACGGCGGTAAAGATAGACCAGCTGATCCGCCCCATCAATGCCCTGGATGAGCTCTGCCGCCTCATGAAGTCCTTTGTCCACCCAAAGC
CTGGTGCTGCTGGGAGTGTGGGCGCCGGCCTCATCCCCATCTCCTCGGAGCTCTGCTACCGCCTGGGGGCCTGCCAGATGGTCATGTGTG
GCACAGGCATGCAGAGGAGCACCCTGAGCGTGTCCCTGGAGCAGGCGGCCATCTTGGCACGGAGCCACGGGTTGCTGCCCAAGTGCATCA
TGCAGGCCACGGACATCATGCGGAAGCAGGGCCCAAGGGTGGAGATTCTGGCCAAAAACCTGCGAGTCAAGGACCAGATGCCCCAGGGTG
CTCCGCGCCTCTACCGCCTCTGCCAGCCGCCGGTGGATGGGGACCTCTGAACACCCAAATGCCCCACGCTGGGCCGCGGCCTCTGGAGCT
GGGATTTGGGAGGACACAGCAGGCAGCGCTGGCCTTCTCCAGGGATGGCCCAAGGCTTCCGCAGCCGCCCGTTCCGGGACCTGCCCAGCG
TCCTCCCTGCCTCCTTCCGGGACAAGCCTGGCCACCCTCGCTGTGATGACGAGCTGGCTGATTGGCCCTGGGCCGGCCCATTCTTCACAC
GCCTGCCAGAAGCTGGAGGGGTGCTGGAGACCCATAGAGCTGATGGGAGCAGCTGGTGCCTGGCCTTCGGCTCCTGCGTCCCCAGAACCC
AAGGGAACGTCATGGAGGCCACATGGGGCCACCCGGCTCCCTCGGGATGGCTCCGCCTGCACTTTTGAAACCCCGGTTTCCTTCAACGTC
CACATTCCAGGTGACCACACGTGTCTCCTCCTCCTCATCTTAGCTTCCAGGTTCACCCTAACCCTGTACTAACCTGCTTGGTGGACTTGG
AAAAGACTTGGCTCTGTCGGGAAAGGAGAGACGGGGCCTCCATCACGCCTGTTACCAGAGGATCCCCGAGAGCCACACCAGCTCTGGACA
TCACCGCCCCTGGAACTGGGGCCACCAGCCCTGGGCACGAGATTTGCTCTGACTTTATTTATATGGCATGAAATCTCTGGTTTATTTTGG
GATTTTTTGTTGTTGGTGTTGTCAAAGTTTGTTTTTTCTAAAGTTGTGTGATTATATATTTGACATTTTACATTTCAAAGAAAGGTATGT
TGTCTAACAGGGGACCAACAGAAGGTAGTATTGACAACTGTTCCTGCTTCTACTAAAAAAAAAAGAGCACAAAAGAAAAACTAAATTATT
GAAAAATTAAAAAATGTCATTGTTTCCTGTTTGTTAATATTAGGGTTGTAAGGTGTCGTTTTGAGGTATCGACTGTGATTCCTTCCCCCA
CCCTCCATTCTCCAGCGGTTGGCCGGTGTTAGAACTCGCTCTCTTTGAGTGACTGGCTACAAGGGCCTGAGAGGTGGCCAGCCAGGGTTG
GAGCTGGAGGGGATGGAGCCCCACCTGAGGTGCCGTGTCACACGGGTTAGAGGGTCACTGGGAAACACCGGGCGGTGGCTTCTGTGATTT
ATTTTCTTGATGGTAACTTCTCAGAGCAGGGCGATTGGGACATCACCAGCCAGAGCACAGGAAGCCACCCTGCCTGCTGGGGAGGAGGGA
CCCACACAAGCCCCCTCGGCAGTTTGTCCCCCCAGCTTCGGTATGCCTTCAGGGAAAGGTCACAGCTGGGGAGGAAGCGGGGGGACGCCT
GTCACCCCTGGCAGGTGGTGAGTTCAGGTGGGGGCTCCCTGCTGCCCCCAGGCCTGGGAGCTTGAAGCCCTCCCGGCATCTGGCATCCGA
GCCTCCCGCCCTCCAGGGTGCGCTTCCCTCTCTTGCCGCAGCATACACGAGGGCAGGCAGTGGCCTTGTCACTGTATCTTGCATCAGAGA
CAAAGGAGGACCCGCTTTAGCCCTGCTGCGGGAAATGGGGGAGGGCCCAGGGCCAGCGCATTGTGCACTGGTTTACTTTAAAATGTACAG

>27328_27328_3_ERCC6-PREX1_ERCC6_chr10_50736463_ENST00000355832_PREX1_chr20_47324959_ENST00000371941_length(amino acids)=1454AA_BP=1
MQELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFD
NLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLD
AIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGI
IHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAV
ALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGS
LAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGL
CAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSL
CEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDT
KLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPM
SYTQHCITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLS
TITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGS
DEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDPWNL
PNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSKQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATG
VLLHCQSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLRLHT
ALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPG
AAGSVGAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQMPQGAP

--------------------------------------------------------------
>27328_27328_4_ERCC6-PREX1_ERCC6_chr10_50736463_ENST00000355832_PREX1_chr20_47324959_ENST00000396220_length(transcript)=6824nt_BP=731nt
TGGGTTCCAAGGCGGCTGGCGGCGGTAGCGTCTCTGTTTCCTTGTGGGCGCTCGCGCGGCCCTGGGTAGTCTGTAGAGAATGCCAAATGA
GGGAATCCCCCACTCAAGTCAAACTCAGGAGCAAGACTGTTTACAGAGTCAACCTGTCAGTAATAATGAAGAAATGGCAATCAAGCAAGA
AAGTGGTGGTGATGGGGAGGTGGAGGAGTACCTCTCCTTTCGTTCTGTGGGTGACGGGCTGTCCACCTCTGCTGTGGGGTGCGCATCAGC
AGCTCCGAGGAGAGGGCCAGCCCTGCTGCACATCGACCGACATCAGATCCAGGCAGTAGAGCCTAGCGCCCAGGCCCTTGAGCTGCAGGG
TTTGGGTGTGGACGTCTATGACCAGGACGTGCTGGAACAGGGAGTGCTTCAGCAGGTGGACAATGCCATCCATGAGGCCAGCCGTGCCTC
CCAGCTCGTTGACGTGGAGAAGGAGTATCGGTCGGTCCTGGATGACCTCACGTCATGTACGACATCCCTAAGGCAAATCAATAAAATTAT
TGAACAGCTTAGCCCTCAAGCTGCCACCAGCAGAGACATCAACAGGAAACTAGATTCTGTAAAACGACAGAAGTATAATAAGGAACAACA
GCTAAAAAAGATCACTGCAAAACAAAAGCATCTCCAGGCCATCCTTGGAGGAGCAGAGGTGAAAATTGAACTAGATCACGCCAGTCTGGA
GGAGGATGCAGGAGCTGGCCAAGAGGACTCCCGGCAAGCACCCAGACCACCCCGCGGTCCAGAGTGCCCTGCAGGCCATGAAGACCGTTT
GCTCCAACATCAATGAGACCAAGCGGCAGATGGAGAAGCTGGAAGCCCTGGAGCAGCTGCAGTCCCACATCGAAGGCTGGGAGGGTTCCA
ACCTCACAGACATCTGCACTCAGCTCCTCCTGCAAGGGACTTTGTTAAAGATCTCTGCGGGCAACATCCAGGAAAGGGCCTTCTTCCTCT
TCGACAACCTTCTCGTCTACTGCAAGCGGAAATCCAGGGTCACCGGGAGCAAGAAGTCCACCAAGAGGACCAAATCCATCAACGGCTCCC
TCTACATCTTCAGGGGTCGAATCAACACTGAAGTCATGGAGGTGGAGAATGTGGAAGATGGGACAGCGGATTACCATAGCAACGGCTATA
CCGTCACCAACGGCTGGAAGATCCACAACACGGCCAAGAATAAGTGGTTTGTCTGCATGGCCAAGACGGCAGAGGAGAAGCAGAAGTGGC
TGGATGCCATCATCCGCGAGCGGGAGCAGCGCGAGAGCCTGAAGCTGGGCATGGAGCGTGATGCCTACGTCATGATTGCGGAGAAGGGGG
AGAAGCTGTACCACATGATGATGAACAAGAAGGTGAACCTCATCAAGGACCGCCGGAGAAAGCTGAGCACTGTCCCCAAGTGCTTTCTTG
GCAATGAGTTCGTTGCCTGGCTCCTAGAAATTGGTGAAATCAGCAAGACGGAAGAAGGAGTCAACTTGGGCCAAGCCCTGTTGGAGAATG
GCATCATCCACCATGTTTCCGACAAGCACCAGTTCAAGAATGAGCAGGTGATGTATCGCTTCCGCTACGACGATGGCACCTACAAGGCCC
GAAGTGAGCTGGAGGACATCATGTCCAAGGGTGTGAGGCTTTACTGCCGTCTTCACAGCCTCTACACCCCGGTGATCAAAGACCGTGATT
ACCACCTGAAGACCTACAAGTCAGTGCTTCCCGGGAGCAAGCTGGTGGACTGGCTGCTGGCTCAGGGAGACTGCCAGACTCGGGAGGAGG
CAGTGGCGCTCGGCGTGGGTCTGTGCAACAATGGCTTCATGCACCACGTGCTGGAGAAGAGCGAGTTCAGGGATGAGTCCCAGTACTTCC
GCTTTCATGCTGACGAGGAGATGGAGGGGACCAGCAGCAAGAACAAACAGCTTCGCAACGACTTCAAGCTGGTGGAGAACATTCTGGCCA
AGCGCCTGCTGATCCTGCCCCAGGAGGAGGACTATGGCTTTGACATCGAGGAGAAGAACAAGGCTGTGGTGGTGAAGTCCGTCCAGAGGG
GCTCGCTGGCTGAGGTGGCTGGCCTGCAGGTGGGGAGGAAGATCTACTCCATCAATGAGGACCTGGTGTTCCTGCGGCCGTTTTCAGAGG
TGGAGTCCATCCTCAACCAGTCCTTCTGCTCCCGCCGCCCTCTGCGCCTCCTGGTGGCCACGAAGGCCAAAGAGATCATCAAAATCCCCG
ACCAGCCGGACACACTGTGCTTCCAGATTCGTGGAGCTGCCCCACCGTACGTCTATGCTGTGGGGAGAGGCTCTGAGGCCATGGCTGCAG
GGCTCTGTGCTGGTCAGTGCATTCTGAAGGTCAATGGCAGCAACGTGATGAACGATGGTGCCCCTGAGGTCCTGGAGCACTTCCAGGCAT
TCCGGAGTCGGCGCGAAGAGGCCCTGGGCCTGTACCAGTGGATCTACCACACCCATGAGGATGCCCAGGAAGCACGAGCCAGTCAGGAGG
CCTCCACTGAGGACCCCAGTGGCGAGCAGGCCCAGGAGGAAGACCAGGCTGATTCAGCCTTCCCACTGCTGTCCCTGGGTCCCCGGCTGA
GCCTGTGTGAGGACAGCCCCATGGTCACCCTGACTGTGGACAACGTGCACCTGGAACACGGCGTGGTGTATGAGTATGTGAGCACGGCAG
GCGTCAGGTGCCATGTGCTGGAGAAGATCGTGGAGCCCCGCGGCTGCTTCGGCCTCACCGCCAAGATCCTCGAGGCCTTTGCTGCCAATG
ACAGCGTCTTCGTGGAGAACTGCAGGCGGCTCATGGCCCTGAGCAGCGCCATCGTGACCATGCCCCACTTTGAGTTCCGCAACATCTGTG
ACACCAAGCTGGAGAGCATTGGCCAGAGGATTGCCTGCTACCAGGAGTTTGCAGCCCAACTGAAGAGCAGGGTCAGCCCACCCTTCAAAC
AAGCCCCCCTGGAGCCCCACCCGCTGTGTGGCCTGGACTTCTGCCCCACCAATTGCCACATCAACCTCATGGAAGTGTCCTACCCCAAGA
CCACCCCCTCAGTGGGCAGGTCCTTCAGCATCCGCTTTGGACGCAAACCCTCCCTCATCGGCCTTGACCCGGAGCAAGGCCACCTGAACC
CCATGTCGTACACCCAGCACTGCATCACCACCATGGCTGCTCCCTCCTGGAAGTGCTTGCCTGCTGCAGAGGGTGATCCCCAAGGCCAGG
GTCTCCATGATGGCAGCTTCGGGCCAGCCAGTGGGACCCTTGGTCAGGAAGACCGGGGCCTCAGCTTCCTACTCAAGCAGGAGGACCGTG
AGATCCAGGATGCCTACCTGCAGCTCTTCACCAAGCTGGATGTGGCCCTGAAGGAGATGAAGCAATATGTCACCCAGATCAACAGGCTGC
TGTCCACCATCACAGAGCCCACCTCGGGTGGGTCCTGCGACGCATCCTTGGCTGAGGAGGCCTCCTCCCTGCCCCTGGTCAGTGAAGAGA
GCGAGATGGACAGGAGTGACCATGGGGGCATCAAGAAGGTGTGCTTCAAGGTGGCCGAGGAGGACCAGGAGGACTCAGGCCACGACACCA
TGAGTTATCGCGACTCCTACAGCGAGTGTAACAGCAATCGAGACTCGGTCCTGTCCTACACCAGCGTGAGAAGTAACAGCTCCTACTTGG
GCAGCGACGAGATGGGGTCTGGAGATGAGCTGCCCTGTGACATGCGGATCCCATCTGACAAGCAGGACAAGCTTCATGGCTGCCTGGAGC
ACCTCTTTAACCAGGTGGACTCCATCAATGCTCTCCTCAAGGGGCCAGTCATGAGCCGGGCTTTCGAAGAGACCAAGCATTTCCCTATGA
ACCACAGCTTACAAGAGTTTAAACAGAAAGAAGAGTGTACAATCCGTGGCCGGAGCCTGATCCAGATTAGCATCCAGGAGGACCCCTGGA
ACCTCCCCAACTCCATCAAGACCCTGGTGGACAACATTCAGAGATATGTGGAAGATGGGAAGAACCAGCTGCTCCTGGCCTTGCTGAAGT
GCACAGACACGGAGCTGCAGCTGCGCAGAGACGCGATCTTCTGCCAGGCCCTGGTGGCCGCCGTGTGCACCTTCTCCAAGCAGCTGCTGG
CGGCCCTGGGCTACCGCTACAACAACAATGGCGAGTACGAGGAGAGCAGCCGCGACGCCAGCCGCAAGTGGCTGGAGCAGGTGGCGGCCA
CGGGCGTCCTGCTGCACTGCCAGTCCCTGCTCTCGCCAGCCACAGTGAAGGAGGAACGGACCATGCTGGAGGACATCTGGGTGACGCTGT
CAGAGCTGGACAATGTCACCTTCTCCTTTAAGCAGCTGGACGAGAACTATGTGGCCAACACCAACGTCTTCTACCACATTGAGGGCAGCC
GGCAGGCGCTGAAGGTCATCTTCTACCTCGACAGCTACCACTTCTCCAAGCTGCCCTCCCGCCTGGAGGGTGGGGCCAGCCTGAGGCTGC
ACACAGCGCTGTTCACGAAAGGTGAGCTTCAGGCCTGGGGCAGGGAGGACCACGGGGGCCGGGCCAAGGCCACCAAGCACACCGGCTCCC
AACCGCCTGCCCGCCCCCGACATCTCCCCTCCCAGTGCTGGAGAACGTGGAGGGGCTGCCTTCTCCAGGCAGCCAGGCCGCGGAGGATTT
GCAGCAGGACATCAACGCGCAGTCCCTGGAGAAAGTTCAGCAGTATTACCGCAAACTCAGGGCATTTTACCTGGAGCGGTCTAACCTGCC
CACGGATGCCAGCACCACGGCGGTAAAGATAGACCAGCTGATCCGCCCCATCAATGCCCTGGATGAGCTCTGCCGCCTCATGAAGTCCTT
TGTCCACCCAAAGCCTGGTGCTGCTGGGAGTGTGGGCGCCGGCCTCATCCCCATCTCCTCGGAGCTCTGCTACCGCCTGGGGGCCTGCCA
GATGGTCATGTGTGGCACAGGCATGCAGAGGAGCACCCTGAGCGTGTCCCTGGAGCAGGCGGCCATCTTGGCACGGAGCCACGGGTTGCT
GCCCAAGTGCATCATGCAGGCCACGGACATCATGCGGAAGCAGGGCCCAAGGGTGGAGATTCTGGCCAAAAACCTGCGAGTCAAGGACCA
GATGCCCCAGGGTGCTCCGCGCCTCTACCGCCTCTGCCAGCCGCCGGTGGATGGGGACCTCTGAACACCCAAATGCCCCACGCTGGGCCG
CGGCCTCTGGAGCTGGGATTTGGGAGGACACAGCAGGCAGCGCTGGCCTTCTCCAGGGATGGCCCAAGGCTTCCGCAGCCGCCCGTTCCG
GGACCTGCCCAGCGTCCTCCCTGCCTCCTTCCGGGACAAGCCTGGCCACCCTCGCTGTGATGACGAGCTGGCTGATTGGCCCTGGGCCGG
CCCATTCTTCACACGCCTGCCAGAAGCTGGAGGGGTGCTGGAGACCCATAGAGCTGATGGGAGCAGCTGGTGCCTGGCCTTCGGCTCCTG
CGTCCCCAGAACCCAAGGGAACGTCATGGAGGCCACATGGGGCCACCCGGCTCCCTCGGGATGGCTCCGCCTGCACTTTTGAAACCCCGG
TTTCCTTCAACGTCCACATTCCAGGTGACCACACGTGTCTCCTCCTCCTCATCTTAGCTTCCAGGTTCACCCTAACCCTGTACTAACCTG
CTTGGTGGACTTGGAAAAGACTTGGCTCTGTCGGGAAAGGAGAGACGGGGCCTCCATCACGCCTGTTACCAGAGGATCCCCGAGAGCCAC
ACCAGCTCTGGACATCACCGCCCCTGGAACTGGGGCCACCAGCCCTGGGCACGAGATTTGCTCTGACTTTATTTATATGGCATGAAATCT
CTGGTTTATTTTGGGATTTTTTGTTGTTGGTGTTGTCAAAGTTTGTTTTTTCTAAAGTTGTGTGATTATATATTTGACATTTTACATTTC
AAAGAAAGGTATGTTGTCTAACAGGGGACCAACAGAAGGTAGTATTGACAACTGTTCCTGCTTCTACTAAAAAAAAAAGAGCACAAAAGA
AAAACTAAATTATTGAAAAATTAAAAAATGTCATTGTTTCCTGTTTGTTAATATTAGGGTTGTAAGGTGTCGTTTTGAGGTATCGACTGT
GATTCCTTCCCCCACCCTCCATTCTCCAGCGGTTGGCCGGTGTTAGAACTCGCTCTCTTTGAGTGACTGGCTACAAGGGCCTGAGAGGTG
GCCAGCCAGGGTTGGAGCTGGAGGGGATGGAGCCCCACCTGAGGTGCCGTGTCACACGGGTTAGAGGGTCACTGGGAAACACCGGGCGGT
GGCTTCTGTGATTTATTTTCTTGATGGTAACTTCTCAGAGCAGGGCGATTGGGACATCACCAGCCAGAGCACAGGAAGCCACCCTGCCTG
CTGGGGAGGAGGGACCCACACAAGCCCCCTCGGCAGTTTGTCCCCCCAGCTTCGGTATGCCTTCAGGGAAAGGTCACAGCTGGGGAGGAA
GCGGGGGGACGCCTGTCACCCCTGGCAGGTGGTGAGTTCAGGTGGGGGCTCCCTGCTGCCCCCAGGCCTGGGAGCTTGAAGCCCTCCCGG
CATCTGGCATCCGAGCCTCCCGCCCTCCAGGGTGCGCTTCCCTCTCTTGCCGCAGCATACACGAGGGCAGGCAGTGGCCTTGTCACTGTA
TCTTGCATCAGAGACAAAGGAGGACCCGCTTTAGCCCTGCTGCGGGAAATGGGGGAGGGCCCAGGGCCAGCGCATTGTGCACTGGTTTAC

>27328_27328_4_ERCC6-PREX1_ERCC6_chr10_50736463_ENST00000355832_PREX1_chr20_47324959_ENST00000396220_length(amino acids)=1356AA_BP=1
MQELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFD
NLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLD
AIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGI
IHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAV
ALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGS
LAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGL
CAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSL
CEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDT
KLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPM
SYTQHCITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLS
TITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGS
DEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDPWNL
PNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSKQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATG
VLLHCQSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLRLHT
ALFTKGELQAWGREDHGGRAKATKHTGSQPPARPRHLPSQCWRTWRGCLLQAARPRRICSRTSTRSPWRKFSSITANSGHFTWSGLTCPR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ERCC6-PREX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ERCC6-PREX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ERCC6-PREX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERCC6C0751038Cockayne Syndrome, Type II14CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneERCC6C0009207Cockayne Syndrome9CTD_human;GENOMICS_ENGLAND
HgeneERCC6C0751037Cockayne Syndrome, Type III7CTD_human
HgeneERCC6C0751039Cockayne Syndrome, Type I7CTD_human
HgeneERCC6C0265201De Sanctis-Cacchione syndrome4CTD_human;GENOMICS_ENGLAND
HgeneERCC6C1833561UV-Sensitive Syndrome4CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneERCC6C0025958Microcephaly2CTD_human
HgeneERCC6C0220722Cerebrooculofacioskeletal Syndrome 12CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneERCC6C1956147Microlissencephaly2CTD_human
HgeneERCC6C3551173UV-SENSITIVE SYNDROME 12GENOMICS_ENGLAND
HgeneERCC6C3853041Severe Congenital Microcephaly2CTD_human
HgeneERCC6C0003886Arthrogryposis1CTD_human
HgeneERCC6C0013421Dystonia1GENOMICS_ENGLAND
HgeneERCC6C0018273Growth Disorders1CTD_human
HgeneERCC6C0024121Lung Neoplasms1CTD_human
HgeneERCC6C0026010Microphthalmos1CTD_human
HgeneERCC6C0033922Psychomotor Disorders1CTD_human
HgeneERCC6C0086543Cataract1CTD_human
HgeneERCC6C0231341Premature aging syndrome1CTD_human
HgeneERCC6C0242379Malignant neoplasm of lung1CTD_human
HgeneERCC6C0242383Age related macular degeneration1CTD_human
HgeneERCC6C0376634Craniofacial Abnormalities1CTD_human
HgeneERCC6C0424230Motor retardation1CTD_human
HgeneERCC6C0524524Pseudoaphakia1CTD_human
HgeneERCC6C0751456Developmental Psychomotor Disorders1CTD_human
HgeneERCC6C1384666hearing impairment1CTD_human
HgeneERCC6C1510497Lens Opacities1CTD_human
HgeneERCC6C4310783PREMATURE OVARIAN FAILURE 111CTD_human;UNIPROT