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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ERG-APP (FusionGDB2 ID:HG2078TG351)

Fusion Gene Summary for ERG-APP

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG-APP
Fusion gene ID: hg2078tg351
HgeneTgene
Gene symbol

ERG

APP

Gene ID

2078

351

Gene nameETS transcription factor ERGamyloid beta precursor protein
Synonymserg-3|p55AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4
Cytomap('ERG')('APP')

21q22.2

21q21.3

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avianamyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor protei
Modification date2020032020200329
UniProtAcc

P11308

.
Ensembl transtripts involved in fusion geneENST00000288319, ENST00000398905, 
ENST00000398907, ENST00000429727, 
ENST00000398910, ENST00000417133, 
ENST00000442448, ENST00000453032, 
ENST00000485493, ENST00000398897, 
ENST00000398911, ENST00000398919, 
Fusion gene scores* DoF score19 X 16 X 5=152025 X 18 X 10=4500
# samples 3127
** MAII scorelog2(31/1520*10)=-2.29373120305671
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/4500*10)=-4.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERG [Title/Abstract] AND APP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERG(39870286)-APP(27484463), # samples:1
ERG(40033582)-APP(27484463), # samples:1
Anticipated loss of major functional domain due to fusion event.ERG-APP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-APP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-APP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-APP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826

TgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

TgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668

TgeneAPP

GO:1905606

regulation of presynapse assembly

19726636


check buttonFusion gene breakpoints across ERG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across APP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8530-01AERGchr21

40033582

-APPchr21

27484463

-
ChimerDB4STADTCGA-D7-A4Z0ERGchr21

39870286

-APPchr21

27484463

-


Top

Fusion Gene ORF analysis for ERG-APP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000288319ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000288319ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000288319ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000398905ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000398905ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000398905ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000398907ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000398907ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000398907ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000429727ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000429727ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
5CDS-5UTRENST00000429727ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000288319ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000288319ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000288319ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000288319ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000288319ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000288319ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398905ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398905ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398905ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398905ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398905ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398905ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398907ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398907ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398907ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398907ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398907ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000398907ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000429727ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000429727ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000429727ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000429727ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000429727ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
5CDS-intronENST00000429727ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
5UTR-3CDSENST00000398910ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
5UTR-3CDSENST00000417133ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
5UTR-3CDSENST00000442448ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
5UTR-3CDSENST00000453032ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
5UTR-3CDSENST00000485493ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000398910ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000398910ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000398910ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000417133ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000417133ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000417133ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000442448ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000442448ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000442448ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000453032ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
5UTR-5UTRENST00000453032ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
5UTR-5UTRENST00000453032ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
5UTR-5UTRENST00000485493ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000485493ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
5UTR-5UTRENST00000485493ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000398910ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000398910ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000398910ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000398910ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000398910ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000398910ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000417133ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000417133ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000417133ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000417133ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000417133ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000417133ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000442448ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000442448ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000442448ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000442448ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000442448ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000442448ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000453032ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
5UTR-intronENST00000453032ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
5UTR-intronENST00000453032ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
5UTR-intronENST00000453032ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
5UTR-intronENST00000453032ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
5UTR-intronENST00000453032ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
5UTR-intronENST00000485493ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000485493ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000485493ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000485493ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000485493ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
5UTR-intronENST00000485493ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
In-frameENST00000288319ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
In-frameENST00000398905ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
In-frameENST00000398907ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
In-frameENST00000429727ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000288319ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000398897ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000398897ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000398905ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000398907ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000398910ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000398911ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000398911ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000398919ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000398919ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000417133ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000429727ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000442448ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-3CDSENST00000453032ENST00000346798ERGchr21

40033582

-APPchr21

27484463

-
intron-3CDSENST00000485493ENST00000346798ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000288319ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000288319ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000288319ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398897ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398897ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398897ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398897ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398897ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398897ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398905ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398905ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398905ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398907ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398907ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398907ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398910ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398910ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398910ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398911ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398911ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398911ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398911ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398911ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398911ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398919ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398919ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398919ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398919ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000398919ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000398919ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000417133ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000417133ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000417133ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000429727ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000429727ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000429727ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000442448ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000442448ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000442448ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000453032ENST00000440126ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000453032ENST00000448388ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000453032ENST00000474136ERGchr21

40033582

-APPchr21

27484463

-
intron-5UTRENST00000485493ENST00000440126ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000485493ENST00000448388ERGchr21

39870286

-APPchr21

27484463

-
intron-5UTRENST00000485493ENST00000474136ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000288319ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000288319ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000288319ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000288319ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000288319ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000288319ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398897ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398905ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398905ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398905ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398905ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398905ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398905ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398907ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398907ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398907ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398907ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398907ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398907ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398910ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398910ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398910ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398910ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398910ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398910ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398911ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000398919ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000417133ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000417133ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000417133ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000417133ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000417133ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000417133ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000429727ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000429727ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000429727ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000429727ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000429727ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000429727ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000442448ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000442448ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000442448ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000442448ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000442448ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000442448ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000453032ENST00000348990ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000453032ENST00000354192ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000453032ENST00000357903ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000453032ENST00000358918ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000453032ENST00000359726ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000453032ENST00000439274ERGchr21

40033582

-APPchr21

27484463

-
intron-intronENST00000485493ENST00000348990ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000485493ENST00000354192ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000485493ENST00000357903ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000485493ENST00000358918ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000485493ENST00000359726ERGchr21

39870286

-APPchr21

27484463

-
intron-intronENST00000485493ENST00000439274ERGchr21

39870286

-APPchr21

27484463

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398907ERGchr2139870286-ENST00000346798APPchr2127484463-345680622335757
ENST00000398905ERGchr2139870286-ENST00000346798APPchr2127484463-345680622335757
ENST00000288319ERGchr2139870286-ENST00000346798APPchr2127484463-34971211032376757
ENST00000429727ERGchr2139870286-ENST00000346798APPchr2127484463-343559412314757

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398907ENST00000346798ERGchr2139870286-APPchr2127484463-0.0024018260.99759823
ENST00000398905ENST00000346798ERGchr2139870286-APPchr2127484463-0.0024018260.99759823
ENST00000288319ENST00000346798ERGchr2139870286-APPchr2127484463-0.0024499890.9975501
ENST00000429727ENST00000346798ERGchr2139870286-APPchr2127484463-0.0023895160.99761045

Top

Fusion Genomic Features for ERG-APP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ERG-APP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:39870286/chr21:27484463)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

P11308

.
FUNCTION: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018230_26019771.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018274_28019771.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016230_26019696.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016274_28019696.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015230_2600640.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015274_2800640.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017230_26019752.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017274_28019752.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017230_26019753.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017274_28019753.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017230_26019715.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017274_28019715.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017230_26014747.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017274_28014747.0Compositional biasNote=Poly-Thr
TgeneAPPchr21:39870286chr21:27484463ENST0000034679801828_18919771.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018374_56519771.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000034899001628_18919696.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016374_56519696.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000035419201528_1890640.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015374_5650640.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000035790301728_18919752.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017374_56519752.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000035891801728_18919753.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017374_56519753.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000035972601728_18919715.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017374_56519715.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST0000044012601728_18914747.0DomainE1
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017374_56514747.0DomainE2
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018344_36519771.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018724_73419771.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016344_36519696.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016724_73419696.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015344_3650640.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015724_7340640.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017344_36519752.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017724_73419752.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017344_36519753.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017724_73419753.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017344_36519715.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017724_73419715.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017344_36514747.0MotifOX-2
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017724_73414747.0MotifNote=Basolateral sorting signal
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018131_18919771.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018181_18819771.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034679801828_12319771.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018391_42319771.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018491_52219771.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018523_54019771.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034679801896_11019771.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016131_18919696.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016181_18819696.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034899001628_12319696.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016391_42319696.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016491_52219696.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016523_54019696.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034899001696_11019696.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015131_1890640.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015181_1880640.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035419201528_1230640.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015391_4230640.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015491_5220640.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015523_5400640.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035419201596_1100640.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017131_18919752.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017181_18819752.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035790301728_12319752.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017391_42319752.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017491_52219752.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017523_54019752.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035790301796_11019752.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017131_18919753.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017181_18819753.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035891801728_12319753.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017391_42319753.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017491_52219753.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017523_54019753.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035891801796_11019753.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017131_18919715.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017181_18819715.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035972601728_12319715.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017391_42319715.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017491_52219715.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017523_54019715.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000035972601796_11019715.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017131_18914747.0RegionCuBD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017181_18814747.0RegionNote=Zinc-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000044012601728_12314747.0RegionGFLD subdomain
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017391_42314747.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017491_52214747.0RegionNote=Heparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017523_54014747.0RegionCollagen-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000044012601796_11014747.0RegionHeparin-binding
TgeneAPPchr21:39870286chr21:27484463ENST0000034679801818_70119771.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018723_77019771.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000034899001618_70119696.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016723_77019696.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000035419201518_7010640.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015723_7700640.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000035790301718_70119752.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017723_77019752.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000035891801718_70119753.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017723_77019753.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000035972601718_70119715.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017723_77019715.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST0000044012601718_70114747.0Topological domainExtracellular
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017723_77014747.0Topological domainCytoplasmic
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018702_72219771.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016702_72219696.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015702_7220640.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017702_72219752.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017702_72219753.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017702_72219715.0TransmembraneHelical
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017702_72214747.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERGchr21:39870286chr21:27484463ENST00000288319-110311_3916480.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000398897-19311_3910364.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000398911-110311_3910463.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000398919-112311_3910487.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000417133-112311_3910487.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000442448-111311_3910463.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000453032-19311_3910388.0DNA bindingETS
HgeneERGchr21:39870286chr21:27484463ENST00000288319-110113_1996480.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000398897-19113_1990364.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000398911-110113_1990463.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000398919-112113_1990487.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000417133-112113_1990487.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000442448-111113_1990463.0DomainPNT
HgeneERGchr21:39870286chr21:27484463ENST00000453032-19113_1990388.0DomainPNT


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Fusion Gene Sequence for ERG-APP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27334_27334_1_ERG-APP_ERG_chr21_39870286_ENST00000288319_APP_chr21_27484463_ENST00000346798_length(transcript)=3497nt_BP=121nt
AATCTCATCCGCTCTAAACAACCTCATCAAAACTACTTTCTGGTCAGAGAGAAGCAATAATTATTATTAACATTTATTAACGATCAATAA
ACTTGATCGCATTATGGCCAGCACTATTAAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGG
CAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCAT
CCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAA
GCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGT
TCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAG
TGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACT
GGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGA
TGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGA
GGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCAC
CACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTT
TGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGC
CGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGC
CAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGA
GGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAA
GGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGC
CAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCA
CGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGA
TCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTA
CAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAA
CATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGT
GAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCC
TGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGT
GAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAA
AGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACAC
ATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAA
TCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTAC
CCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAAC
ACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAAT
GGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCA
GTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTG
GGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTA
GAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTT
TGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATA
AAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAA
AACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATA
ACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTT
CTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACA

>27334_27334_1_ERG-APP_ERG_chr21_39870286_ENST00000288319_APP_chr21_27484463_ENST00000346798_length(amino acids)=757AA_BP=6
MASTIKVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRK
QCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES
DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESV
EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD
AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEA
MLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA
VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDAR
PAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH

--------------------------------------------------------------
>27334_27334_2_ERG-APP_ERG_chr21_39870286_ENST00000398905_APP_chr21_27484463_ENST00000346798_length(transcript)=3456nt_BP=80nt
GGTCAGAGAGAAGCAATAATTATTATTAACATTTATTAACGATCAATAAACTTGATCGCATTATGGCCAGCACTATTAAGGTACCCACTG
ATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGG
ATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCA
CCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGA
TTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATG
TTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGC
CCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGG
AGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAG
AAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACG
AAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTG
AACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCG
GATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTA
CCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTG
GGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAAT
GGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGG
AACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCC
TGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGA
AGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACAC
ACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTG
ATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTC
TCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATT
CTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTC
GACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAG
TTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAG
CGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCA
CCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCC
CCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAA
CCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTA
ATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAG
TGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCT
ACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGA
TCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATT
GCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTG
AGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGC
GGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTAT
GACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACAT
TAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGA
TGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGG

>27334_27334_2_ERG-APP_ERG_chr21_39870286_ENST00000398905_APP_chr21_27484463_ENST00000346798_length(amino acids)=757AA_BP=6
MASTIKVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRK
QCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES
DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESV
EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD
AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEA
MLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA
VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDAR
PAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH

--------------------------------------------------------------
>27334_27334_3_ERG-APP_ERG_chr21_39870286_ENST00000398907_APP_chr21_27484463_ENST00000346798_length(transcript)=3456nt_BP=80nt
GGTCAGAGAGAAGCAATAATTATTATTAACATTTATTAACGATCAATAAACTTGATCGCATTATGGCCAGCACTATTAAGGTACCCACTG
ATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGG
ATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCA
CCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGA
TTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATG
TTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGC
CCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGG
AGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAG
AAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACG
AAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTG
AACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCG
GATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTA
CCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTG
GGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAAT
GGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGG
AACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCC
TGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGA
AGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACAC
ACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTG
ATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTC
TCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATT
CTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTC
GACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAG
TTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAG
CGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCA
CCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCC
CCGCCACAGCAGCCTCTGAAGTTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAA
CCCGTTTTATGATTTACTCATTATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTA
ATGTATTCTATCTCTCTTTACATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAG
TGCATGAATAGATTCTCTCCTGATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCT
ACTTTACATATGCTTTAAGAATCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGA
TCACTATGCATTTTAAAGTTAAACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATT
GCTGCTTCTGCTATATTTGTGATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTG
AGACTTCAAGCTTTTCTTTTTTTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGC
GGGTGGGGAGGGGTGCTCTGCTGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTAT
GACATGATCGCTTTCTACACTGTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACAT
TAAATAATCGAAGTAATTTTGGGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGA
TGAAAATGGAAGTGGCAATATAAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGG

>27334_27334_3_ERG-APP_ERG_chr21_39870286_ENST00000398907_APP_chr21_27484463_ENST00000346798_length(amino acids)=757AA_BP=6
MASTIKVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRK
QCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES
DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESV
EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD
AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEA
MLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA
VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDAR
PAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH

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>27334_27334_4_ERG-APP_ERG_chr21_39870286_ENST00000429727_APP_chr21_27484463_ENST00000346798_length(transcript)=3435nt_BP=59nt
ATTATTAACATTTATTAACGATCAATAAACTTGATCGCATTATGGCCAGCACTATTAAGGTACCCACTGATGGTAATGCTGGCCTGCTGG
CTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCA
AAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACC
AACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTG
GTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACT
GGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCC
GAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGT
GGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAG
AAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCA
CCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGT
GCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACA
ACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAG
ATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCC
ATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAG
CAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGA
GACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTC
TGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAA
AGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGC
GCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGC
AAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAA
CGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGC
CAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAA
ATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGT
TCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCT
TGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGT
CCAAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAG
TTGGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCAT
TATCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTAC
ATTTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCT
GATTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAA
TCGATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTA
AACATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTG
ATATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTT
TTGTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGC
TGGTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACT
GTATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTG
GGTGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATAT
AAGGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCATGTAAATAAATAC

>27334_27334_4_ERG-APP_ERG_chr21_39870286_ENST00000429727_APP_chr21_27484463_ENST00000346798_length(amino acids)=757AA_BP=6
MASTIKVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRK
QCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES
DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESV
EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD
AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEA
MLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA
VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDAR
PAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHH

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Fusion Gene PPI Analysis for ERG-APP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018732_75119.0771.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016732_75119.0696.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015732_7510640.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017732_75119.0752.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017732_75119.0753.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017732_75119.0715.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017732_75114.0747.0G(o)-alpha
TgeneAPPchr21:39870286chr21:27484463ENST00000346798018695_72219.0771.0PSEN1
TgeneAPPchr21:39870286chr21:27484463ENST00000348990016695_72219.0696.0PSEN1
TgeneAPPchr21:39870286chr21:27484463ENST00000354192015695_7220640.0PSEN1
TgeneAPPchr21:39870286chr21:27484463ENST00000357903017695_72219.0752.0PSEN1
TgeneAPPchr21:39870286chr21:27484463ENST00000358918017695_72219.0753.0PSEN1
TgeneAPPchr21:39870286chr21:27484463ENST00000359726017695_72219.0715.0PSEN1
TgeneAPPchr21:39870286chr21:27484463ENST00000440126017695_72214.0747.0PSEN1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ERG-APP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ERG-APP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms7CTD_human
HgeneERGC0376358Malignant neoplasm of prostate7CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneERGC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneERGC0279980Extra-osseous Ewing's sarcoma1ORPHANET
HgeneERGC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneC0002395Alzheimer's Disease63CTD_human;UNIPROT
TgeneC0011265Presenile dementia35CTD_human
TgeneC0276496Familial Alzheimer Disease (FAD)35CTD_human
TgeneC0494463Alzheimer Disease, Late Onset35CTD_human
TgeneC0546126Acute Confusional Senile Dementia35CTD_human
TgeneC0750900Alzheimer's Disease, Focal Onset35CTD_human
TgeneC0750901Alzheimer Disease, Early Onset35CTD_human
TgeneC0025261Memory Disorders16CTD_human
TgeneC0233794Memory impairment16CTD_human
TgeneC0751292Age-Related Memory Disorders16CTD_human
TgeneC0751293Memory Disorder, Semantic16CTD_human
TgeneC0751294Memory Disorder, Spatial16CTD_human
TgeneC0751295Memory Loss16CTD_human
TgeneC0027746Nerve Degeneration11CTD_human
TgeneC0023186Learning Disorders8CTD_human
TgeneC0751262Adult Learning Disorders8CTD_human
TgeneC0751263Learning Disturbance8CTD_human
TgeneC0751265Learning Disabilities8CTD_human
TgeneC1330966Developmental Academic Disorder8CTD_human
TgeneC2751536CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED7CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0009241Cognition Disorders5CTD_human
TgeneC0011570Mental Depression5PSYGENET
TgeneC0011581Depressive disorder5PSYGENET
TgeneC0234544Todd Paralysis5CTD_human
TgeneC0522224Paralysed5CTD_human
TgeneC0497327Dementia3CTD_human;GENOMICS_ENGLAND
TgeneC2931672Cerebral hemorrhage with amyloidosis, hereditary, Dutch type3CTD_human;ORPHANET
TgeneC0270715Degenerative Diseases, Central Nervous System2CTD_human
TgeneC0333463Senile Plaques2CTD_human
TgeneC0524851Neurodegenerative Disorders2CTD_human
TgeneC0600467Neurogenic Inflammation2CTD_human
TgeneC0751733Degenerative Diseases, Spinal Cord2CTD_human
TgeneC2751494CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ARCTIC VARIANT2CTD_human
TgeneC2936349Plaque, Amyloid2CTD_human
TgeneC3888307CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, FLEMISH VARIANT2CTD_human
TgeneC3888308CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ITALIAN VARIANT2CTD_human
TgeneC3888309CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, IOWA VARIANT2CTD_human
TgeneC0002622Amnesia1CTD_human
TgeneC0002726Amyloidosis1CTD_human
TgeneC0003469Anxiety Disorders1CTD_human
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0006111Brain Diseases1CTD_human
TgeneC0011573Endogenous depression1PSYGENET
TgeneC0016667Fragile X Syndrome1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0027540Necrosis1CTD_human
TgeneC0033141Cardiomyopathies, Primary1CTD_human
TgeneC0036529Myocardial Diseases, Secondary1CTD_human
TgeneC0036572Seizures1GENOMICS_ENGLAND
TgeneC0037928Spinal Cord Diseases1CTD_human
TgeneC0038002Splenomegaly1CTD_human
TgeneC0038454Cerebrovascular accident1GENOMICS_ENGLAND
TgeneC0043094Weight Gain1CTD_human
TgeneC0085220Cerebral Amyloid Angiopathy1CTD_human
TgeneC0085584Encephalopathies1CTD_human
TgeneC0231341Premature aging syndrome1CTD_human
TgeneC0233750Hysterical amnesia1CTD_human
TgeneC0233796Temporary Amnesia1CTD_human
TgeneC0234985Mental deterioration1CTD_human
TgeneC0236795Dissociative Amnesia1CTD_human
TgeneC0262497Global Amnesia1CTD_human
TgeneC0270612Leukoencephalopathy1GENOMICS_ENGLAND
TgeneC0338582Sporadic Cerebral Amyloid Angiopathy1CTD_human
TgeneC0338630Senile Paranoid Dementia1CTD_human
TgeneC0338656Impaired cognition1CTD_human
TgeneC0376280Anxiety States, Neurotic1CTD_human
TgeneC0553692Brain hemorrhage1GENOMICS_ENGLAND
TgeneC0750906Tactile Amnesia1CTD_human
TgeneC0750907Amnestic State1CTD_human
TgeneC0751071Familial Dementia1CTD_human
TgeneC0751156FRAXA Syndrome1CTD_human
TgeneC0751157FRAXE Syndrome1CTD_human
TgeneC0878544Cardiomyopathies1CTD_human
TgeneC0948008Ischemic stroke1GENOMICS_ENGLAND
TgeneC1270972Mild cognitive disorder1CTD_human
TgeneC1279420Anxiety neurosis (finding)1CTD_human