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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ERG-PLEKHH1 (FusionGDB2 ID:HG2078TG57475)

Fusion Gene Summary for ERG-PLEKHH1

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG-PLEKHH1
Fusion gene ID: hg2078tg57475
HgeneTgene
Gene symbol

ERG

PLEKHH1

Gene ID

2078

57475

Gene nameETS transcription factor ERGpleckstrin homology, MyTH4 and FERM domain containing H1
Synonymserg-3|p55-
Cytomap('ERG')('PLEKHH1')

21q22.2

14q24.1

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avianpleckstrin homology domain-containing family H member 1PH domain-containing family H member 1pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
Modification date2020032020200313
UniProtAcc

P11308

.
Ensembl transtripts involved in fusion geneENST00000398910, ENST00000398911, 
ENST00000398919, ENST00000417133, 
ENST00000442448, ENST00000398897, 
ENST00000485493, ENST00000288319, 
ENST00000398905, ENST00000398907, 
ENST00000429727, ENST00000453032, 
Fusion gene scores* DoF score19 X 16 X 5=15207 X 8 X 5=280
# samples 319
** MAII scorelog2(31/1520*10)=-2.29373120305671
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERG [Title/Abstract] AND PLEKHH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERG(39947586)-PLEKHH1(68022542), # samples:3
Anticipated loss of major functional domain due to fusion event.ERG-PLEKHH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-PLEKHH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-PLEKHH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-PLEKHH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-PLEKHH1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ERG-PLEKHH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ERG-PLEKHH1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ERG-PLEKHH1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826


check buttonFusion gene breakpoints across ERG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PLEKHH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-CH-5739-01AERGchr21

39947586

-PLEKHH1chr14

68022542

+
ChimerDB4PRADTCGA-CH-5739ERGchr21

39947586

-PLEKHH1chr14

68022542

+


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Fusion Gene ORF analysis for ERG-PLEKHH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000398910ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000398910ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000398911ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000398911ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000398919ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000398919ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000417133ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000417133ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000442448ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5CDS-intronENST00000442448ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5UTR-3CDSENST00000398897ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5UTR-3CDSENST00000485493ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5UTR-intronENST00000398897ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5UTR-intronENST00000398897ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5UTR-intronENST00000485493ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
5UTR-intronENST00000485493ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
Frame-shiftENST00000398910ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
Frame-shiftENST00000417133ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
Frame-shiftENST00000442448ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
In-frameENST00000398911ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
In-frameENST00000398919ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-3CDSENST00000288319ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-3CDSENST00000398905ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-3CDSENST00000398907ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-3CDSENST00000429727ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-3CDSENST00000453032ENST00000329153ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000288319ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000288319ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000398905ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000398905ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000398907ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000398907ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000429727ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000429727ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000453032ENST00000417684ERGchr21

39947586

-PLEKHH1chr14

68022542

+
intron-intronENST00000453032ENST00000559832ERGchr21

39947586

-PLEKHH1chr14

68022542

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000398911ERGchr2139947586-ENST00000329153PLEKHH1chr1468022542+653418814041561338
ENST00000398919ERGchr2139947586-ENST00000329153PLEKHH1chr1468022542+668033428643021338

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398911ENST00000329153ERGchr2139947586-PLEKHH1chr1468022542+0.0014426080.9985574
ENST00000398919ENST00000329153ERGchr2139947586-PLEKHH1chr1468022542+0.0015818550.9984181

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Fusion Genomic Features for ERG-PLEKHH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ERGchr2139947585-PLEKHH1chr1468022541+1.85E-081
ERGchr2139947585-PLEKHH1chr1468022541+1.85E-081
ERGchr2139947585-PLEKHH1chr1468022541+1.85E-081
ERGchr2139947585-PLEKHH1chr1468022541+1.85E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ERG-PLEKHH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:39947586/chr14:68022542)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

P11308

.
FUNCTION: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePLEKHH1chr21:39947586chr14:68022542ENST00000329153129239_242421365.0Compositional biasNote=Poly-Ser
TgenePLEKHH1chr21:39947586chr14:68022542ENST00000329153129578_672421365.0DomainPH 1
TgenePLEKHH1chr21:39947586chr14:68022542ENST00000329153129687_796421365.0DomainPH 2
TgenePLEKHH1chr21:39947586chr14:68022542ENST00000329153129832_986421365.0DomainMyTH4
TgenePLEKHH1chr21:39947586chr14:68022542ENST00000329153129997_1333421365.0DomainFERM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERGchr21:39947586chr14:68022542ENST00000288319-110311_3910480.0DNA bindingETS
HgeneERGchr21:39947586chr14:68022542ENST00000398897-29311_3910364.0DNA bindingETS
HgeneERGchr21:39947586chr14:68022542ENST00000398911-210311_39113463.0DNA bindingETS
HgeneERGchr21:39947586chr14:68022542ENST00000398919-312311_39113487.0DNA bindingETS
HgeneERGchr21:39947586chr14:68022542ENST00000417133-312311_39113487.0DNA bindingETS
HgeneERGchr21:39947586chr14:68022542ENST00000442448-311311_39113463.0DNA bindingETS
HgeneERGchr21:39947586chr14:68022542ENST00000453032-19311_3910388.0DNA bindingETS
HgeneERGchr21:39947586chr14:68022542ENST00000288319-110113_1990480.0DomainPNT
HgeneERGchr21:39947586chr14:68022542ENST00000398897-29113_1990364.0DomainPNT
HgeneERGchr21:39947586chr14:68022542ENST00000398911-210113_19913463.0DomainPNT
HgeneERGchr21:39947586chr14:68022542ENST00000398919-312113_19913487.0DomainPNT
HgeneERGchr21:39947586chr14:68022542ENST00000417133-312113_19913487.0DomainPNT
HgeneERGchr21:39947586chr14:68022542ENST00000442448-311113_19913463.0DomainPNT
HgeneERGchr21:39947586chr14:68022542ENST00000453032-19113_1990388.0DomainPNT
TgenePLEKHH1chr21:39947586chr14:68022542ENST0000032915312928_169421365.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for ERG-PLEKHH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27373_27373_1_ERG-PLEKHH1_ERG_chr21_39947586_ENST00000398911_PLEKHH1_chr14_68022542_ENST00000329153_length(transcript)=6534nt_BP=188nt
GTTATTCCAGGATCTTTGGAGACCCGAGGAAAGCCGTGTTGACCAAAAGCAAGACAAATGACTCACAGAGAAAAAAGATGGCAGAACCAA
GGGCAACTAAAGCCGTCAGGTTCTGAACAGCTGGTAGATGGGCTGGCTTACTGAAGGACATGATTCAGACTGTCCCGGACCCAGCAGCTC
ATATCAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGA
AGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAG
ATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAA
AGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAAAGCCATAATCAGCGCCTGGTGGAGCAGG
TGGGATCCCTTCAAGATGCGCTAGAAGCTATTCAGATAGCTCCTTCACGGAAGCTGCTGGTGCCCCCCTACGGAGCTGCAGAGCAGGATT
CTGTCCCTTCAGAGCCGGGAATCCAGCCTATGGGCCAGGACAGTGGCTCCCAGGCCCAGGGTCTGAAGGCAGCTGTGCTTGCACCTTCCC
CAGGTGCCCTGCAGAGCAAGGACTCTGTTTCTGAAGCAGCAAGCCCCTTGGAGGATTCTAGTTCCAGCACGGTCCATTCTGGGGAAACAG
TAGAGGCCAAGCCCCTTCAACCTCATCTGGGAAGAGAGAGCCCTCCCCACCAGCCATGCATGAAGCTTCTTACCTTCAGATGTAGTTCAG
CTTCCTGGGGTGAGGGTCTGGTTACTGCTCAGAGAGGGATGCTCCCTGGGACAAAGACCTCTGCCAGGGAAGGTGGTCCTGGCAGCAGTC
TGACCCTACCAAAGGTGCGGGCTCCTGGCACCCCGCGGGACAGCATCCAGTTGGCCAAAAGGCACCACAGCCAGCCCCAGGTGGGCCATG
GGCACTTTGGCCGTGTGGTGAACATTGAGACTGAGGCCTTCTCAGCCCTCCACCCCTCTGGCCTTCCTGAGCTGGAGTCCCGAGCTAGGT
CCCGGGAGGAACCAGAGAAGATGGAGATGGAGGAGCCACCCCCAGCAGGGAAGAATGAGGAAAGAGAGAGCCCAAAGGCCCTTGGAGCTG
AGCTGGAGGAAGTGGAGCTGGGTAACAAGCCACCTACACCCCCGCTGCACCAGTTTTCATCCTGGGAGAGCCGGATCTATGCTGTGGCCA
CATCGGGCATGCGGCTCTCAGATATGTCTCCCAGAAGTAATACTGCATGCTGCGCTTCAAGCCCTCCTGCCCTTGTTTCCCCTGGGTCTT
TCTCTGGCCTGGTCTACAAGAATGTCACTGTGCCTGTCTACACAGCACTGAAGGGGAGAGCTACACAGATCAGCAACATGCCCTTTATGG
ACGAGTCCTCTGGGTCTGACGATGACTGCAGCTCTCAGGCGAGTTTCCGAATCTCGGTCCCCTCCTCTGAGTCCAGGAAGACCAGCGGAC
TAGGCAGCCCCCGGGCCATCAAGAGAGGCGTCTCCATGTCCTCACTGAGCTCCGAGGGTGACTACGCCATCCCCCCGGACGCCTGCTCAC
TGGACAGTGACTACTCAGAGCCTGAGCACAAACTGCAGCGCACCTCATCCTACTCCACCGACGGGCTGGGCCTGGGCGGGGAGTCACTGG
AGAAGTCGGGCTACCTGCTGAAAATGGGGAGCCAGGTGAAGACGTGGAAGAGGCGCTGGTTTGTCCTGAGACAGGGACAGATTATGTACT
ACAAGTCCCCGAGTGATGTCATCCGGAAACCTCAAGGCCAAGTGGATCTGAACTCCCGCTGCCAAATTGTTCGAGGGGAGGGTTCACAGA
CGTTTCAGCTCATCTCTGAGAAGAAAACCTACTACCTGACGGCCGATTCACCCAGCCTGCTGGAGGAGTGGATCCGAGTACTCCAGAGCC
TGCTGAAGGTGCAGGCCACCGGGCCTCCAGCTCTGCTTCGGGGTGGCACCAAGCCCACCGTGAAGGGCTGGCTGACCAAGGTAAAGCATG
GCCACTCCAAGGTGGTCTGGTGCGCTCTTGTTGGGAAAATCTTCTACTACTATCGGAGCCATGAGGACAAGCGACCCCTGGGCTGCCTGC
CTGTGCGGGATGCGCACATAGAGGAAGTAGATCGATCCTGTGACTCAGACGAGGACTATGAGGCTGGAGGAACCAGACGGTTGCTTTCCT
CCCACTGCACCCTGGTGATCCACCCCACAGAGCACAGCCCCACCTACCTCCTCATTGGCACCAAGCATGAAAAGGATACGTGGCTCTACC
ACCTCACAGTGGCTGCAGGTGGCAGCAGTGCCAAGGTGGGCACTGCCTATGAGCAGCTCATTGGAAAACTGATGGATGGTGAAGGAGATC
CAGATTCGCCGCTCTGGAGGCACCCCATGCTGTGCTACAGCAAAGACGGCCTATACGCCTCCCTCACCACCCTGCCCTCTGAGGCCTTGC
AGACGGAGGCCCTCAAGCTCTTCAAGTCCTGCCAGCTCTTCATCAACGTGCCGGTGGAAGCTGCCTCGGTGGACTACCATGTGTCCCTGG
CCCAGACCGCACTGCAGGTCTGCCTGGTTCACCCCGAGCTGCAGAGTGAGATCTACTGCCAACTCATGAAGCAGACCAGCTGCCGCCCAC
CTCAGAAGTACTCCCTCATGCAGTGCTGGCAGCTCCTCGCTCTGTGTGCTCCACTTTTCCTGCCTCAGCATCACTTCCTCTGGTATGTCA
AGCAGCAGCTCCAACGCCATGCAGATCCCAGAAGTGAAACTGGCCAGTATGCCACCTACTGCCAGCGGGCAGTGGAGCGGACCCTGCGGA
CCGGGGAGCGGGAAGCCAGGCCATCGCGCATGGAAGTGGTGTCCATCCTGCTGCGTAACCCCTTCCACCACTCCTTGCCCTTCAGCATCC
CCGTGCACTTTACCAACGGGACTTACCATGTGGTTGGTTTTGACGGCTCTTCCACGGTTGATGAGTTCCTCCAGCGGCTGAACCAGGAGA
TAGGCATGAGAAAGCCATCCCACTCTGGCTTTGCCCTCTTCACGGACGATCCCTCGGGCAGGGACCTGGAGCACTGCCTGCAGGGAAGTG
TCAAGATCTGTGATGCCATCTCCAAGTGGGAACAAGCCATGAAGGAGCTGCACCCCGGAAAGTCTGAGGGTGGGACACGCGTCGTGAAGC
TGATGTACAAGAACAGGCTGTACTTTCGCAGTCAAGTCAAAGGGGAGACGGACCGAGAACGGCTGCTCCTTGCCTCTCAAACCAGTAGAG
AGATAGTGGCAGGGAGGTTTCCTATCAACAAGGAATTGGCTCTTGAGATGGCTGCCCTGATGGCCCAGGTAGAATATGGGGACTTGGAGA
AGCCTGCCCTGCCAGGCCCTGGAGGCACATCCCCTGCCAAGGCTCAGCATCTTCTCCAGCAGGTCCTAGACAGGTTCCACCCCAGGCGCT
ATAGACATGGGGCCCCCGCTGAACAGCTGAGGCACCTGGCAGATATGTTGACCACAAAATGGGCAACATTGCAAGGATGCTCCCCTCCTG
AGTGCATCCGCATCTACCTGACCGTGGCCAGGAAATGGCCTTTCTTTGGTGCTAAACTTTTTGCTGCTCAGCCTGCCCAGCTGTCTTCCA
AGGAGAACGCTCTGGTGTGGATTGCTGTGAATGAGGATGGCGTCAGCATCCTGGACCACAACACTATGCAAGTGCACATCACTTACCCCT
ACTCTTCAGTGACAACGTTTGGTGGCTGCAGGGATGACTTCATGCTTGTGATTAGATCTATCCCAGACAAGAGCTCTGGAAAAAGCCACA
TTGAGAAGTTGATCTTCCGGATGGCTGCTCCCAAGATTGCAGAAGCTACCTTCATCATGGCCAGCTATATGAACCATTGCACTACAACTG
TGAACCCCCCCACCAACCCACCCGGAGCCTGCCAGCTGTGGGAACTGGATGGACGACAGTTCTTTTCTTCTGTTTCCTGTGCTACCAAGG
GGCCAACGTTGCTGTGAATATTTCTCCTACCCGATTCCCCAACACCACTAGTGCCTCTGGATTTAGAGATATATATCCTAGGGTATGATA
CTACTGTGACGGGTCTAACAGCCCCCGGCTACTCTTGTTCTGTGAAATGTGTATTTTAGTCTCTGTGAAGCCTTTACTCTCTAGGTGCCT
TATAATGTTTCAGGGCTCAACTTTTTAAAATCCAGACCCAGTGTTAAAACCATTTATTCCTTTTTTCATAAGAATAATGACTCCAGATGC
TACCTGATTCTAGACATAGACAGGGATGATCCACTGTTACTGAGGGCATCAGTGCTATAAGTTAAGGCTTTCTGCACTGGTACTCTCAAG
GAAGCTAATTTTCTTTCTGGGGGGGGCGGGGGACACAGTGTCACTATGTCACCCAGTCCACAGGGTTCAAGCAATTCTCCTGCCTCAGCC
TTCGGAGTGGCTGGGATTACAGGTGTGCGCCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAG
GCTGGTCTCGAACTCCTGACCTCAGGTGATCTGCCCACTTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATCGCCCAGCCCAG
AAGCTAATTTTTTAATATTGTATATGGTCTTATTTATACTTGAAGTTTTGTGAACGTCGCTAAACAGGATAGGACTAAAATTTCCAATTC
TCCTACACTCTGTCAGAAGCCTAGAACTCACTAAACTGGGCTGCCTTTCCCAAATGGGAAAGGTGCTGACAGAGTTGGAGAAAAAAGAAT
AGACTCATTTTTCCCCATTATTGGTATGTAGGCATTGGTACAGCCCCTTCTGGGGCAGTCTTTGCAGGATAACATGCTATACCTGCTAAG
ATTCAAGCTGTTTTCCTCACACTGGACTTTAGGCCAAACCCAGTACCACGCAATGTGCAAGCAAGGGCAGGAGGTAGGTCCAATCTGACC
CCTCCCTGTCTCATTTTAATGACTGGACAGCGCTCGGTGAAGGCTGTGTTCACTGTAGTGGGCCATCATTTGTTTCCTTCTTCTTGTAAA
AGACCAAGCAAATGCACTCTGCTTTTTGCTGCTGTAAGACCACCAAAAATGAGTCAGAAACACAGAAGACTATTTCAGGCATGTGGGCCT
GGATATGCTCCTTGAGACTTCTGGCAAACTTCTGCTGGGAATTAGTTTGAGGGTGAGGGTACATATGTGACATTTGCCCTAGCCTAAGAG
TAGCAGGTAAAAAAAAGTTTCTTTCATCTTTTGCCTTACTGATAATACCATAATCCCCCTCAATTCAGACCTTCTGATTGAGTGCAGAGG
AGACTAGACAGTCTCCTCTAGACAGGTTGTAGACACACCCTCCCCTAACAAAAACAAAACGAAAGAGTTCATACTCTGATTTTCCAACAT
CTAGGAAACTGAGTTTTATTTCCTAGCTCTAAGGCAGCCTTACTATATGTCAGTAAAGTGCTGAAAACTGTATATTTAGCAGTAGCACCC
AAAACCAAGCCTTTAACCCCAACAATGTGTGTATCTTTTGCACAGCAAAAACTGCGAGGCCAGAACTAGTTTATCTGAACACCTCAGCTG
CTGTAAGCTTCTCCTCTCTCACCCCGTAAACTGACAAGCATGATGAAAAAAGAAGCACATCCAAGTTTCTGCCTCTTTTAAATGTACTTG
ACTTTGCAAGGCAAGTAGTTTTACAGCCATTTCTGTTCACACTTTTCACCCCACAACTTGGGGATCTAGCTGAGACATTTCTACCTCGAA
CAAGTCACATGTACCACAGGTTCCTGAATAATTCCTGCAGGGCTGGTGACAGACATAACAGCTCTGGTTTTATAATATCTTGGGTATCTC
TAAGGCCAATAAGGATAACATTATCTACCCAGAGAGTTTAGAAGAAAAGTAGGAGTCCAAAGGAAGAGTAAACAAGAATGGAGCTGTGTT
CACACTGAATTTGGGGTCAATCTATTTCCCCCACCCTCTCTCCTCCCCAACCCTTCAGGAACCCTTTAGTTTATTAATCTTATACAGAAG
AAACTAACTTAGAAACAAAGGATTCAATATTTGCTTATTTATTCTTTGTTAACATGAGAGTCCCATGTCTGAAAACCAAAGTCCAATTTC
TGTCTGGCCTTTTGTCTCATCCTTCTTGGCAAAAGTAGCTTTTGAACTGATATAAAAAAAAATGCTGAGTAACAGAAAAGTATTAATGTG
CTTGACACCATGACTGAAATACTATGATCTTGTTTGTCAATAAAAAGCAGCTATCTGTGAACCAGGTAACTGTGTGTTTTGGAAGATCTG

>27373_27373_1_ERG-PLEKHH1_ERG_chr21_39947586_ENST00000398911_PLEKHH1_chr14_68022542_ENST00000329153_length(amino acids)=1338AA_BP=16
MKDMIQTVPDPAAHIKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQM
RAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLVPPYGAAEQDSVPSEPGIQPMGQDSGS
QAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSSSSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPG
TKTSAREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSGLPELESRARSREEPEKMEMEEPPPAG
KNEERESPKALGAELEEVELGNKPPTPPLHQFSSWESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTAL
KGRATQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSS
YSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADS
PSLLEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVDRSCDSD
EDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDG
LYASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCA
PLFLPQHHFLWYVKQQLQRHADPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGS
STVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGET
DRERLLLASQTSREIVAGRFPINKELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADML
TTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLV

--------------------------------------------------------------
>27373_27373_2_ERG-PLEKHH1_ERG_chr21_39947586_ENST00000398919_PLEKHH1_chr14_68022542_ENST00000329153_length(transcript)=6680nt_BP=334nt
GCTGAGCCCGTCGGCGCCGAGGGAGTTAGTGCGACCCGGCTCGGCGCGCACGGCCAAGGCACGCGCGCTGGCACACGCGGGCGCGGACAC
GCGCGGACACACACGTGCGGGACACGCCCTCCCCCGACGGCGGCGCTAACCTCTCGGTTATTCCAGGATCTTTGGAGACCCGAGGAAAGC
CGTGTTGACCAAAAGCAAGACAAATGACTCACAGAGAAAAAAGATGGCAGAACCAAGGGCAACTAAAGCCGTCAGGTTCTGAACAGCTGG
TAGATGGGCTGGCTTACTGAAGGACATGATTCAGACTGTCCCGGACCCAGCAGCTCATATCAAGATGCAGGAGCTGGAGCAGAGGCTGCT
GGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTC
TGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGA
GAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAA
GCTTGAGATGGAGAATCAGCATCTGAAAAGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCGCTAGAAGCTATTCA
GATAGCTCCTTCACGGAAGCTGCTGGTGCCCCCCTACGGAGCTGCAGAGCAGGATTCTGTCCCTTCAGAGCCGGGAATCCAGCCTATGGG
CCAGGACAGTGGCTCCCAGGCCCAGGGTCTGAAGGCAGCTGTGCTTGCACCTTCCCCAGGTGCCCTGCAGAGCAAGGACTCTGTTTCTGA
AGCAGCAAGCCCCTTGGAGGATTCTAGTTCCAGCACGGTCCATTCTGGGGAAACAGTAGAGGCCAAGCCCCTTCAACCTCATCTGGGAAG
AGAGAGCCCTCCCCACCAGCCATGCATGAAGCTTCTTACCTTCAGATGTAGTTCAGCTTCCTGGGGTGAGGGTCTGGTTACTGCTCAGAG
AGGGATGCTCCCTGGGACAAAGACCTCTGCCAGGGAAGGTGGTCCTGGCAGCAGTCTGACCCTACCAAAGGTGCGGGCTCCTGGCACCCC
GCGGGACAGCATCCAGTTGGCCAAAAGGCACCACAGCCAGCCCCAGGTGGGCCATGGGCACTTTGGCCGTGTGGTGAACATTGAGACTGA
GGCCTTCTCAGCCCTCCACCCCTCTGGCCTTCCTGAGCTGGAGTCCCGAGCTAGGTCCCGGGAGGAACCAGAGAAGATGGAGATGGAGGA
GCCACCCCCAGCAGGGAAGAATGAGGAAAGAGAGAGCCCAAAGGCCCTTGGAGCTGAGCTGGAGGAAGTGGAGCTGGGTAACAAGCCACC
TACACCCCCGCTGCACCAGTTTTCATCCTGGGAGAGCCGGATCTATGCTGTGGCCACATCGGGCATGCGGCTCTCAGATATGTCTCCCAG
AAGTAATACTGCATGCTGCGCTTCAAGCCCTCCTGCCCTTGTTTCCCCTGGGTCTTTCTCTGGCCTGGTCTACAAGAATGTCACTGTGCC
TGTCTACACAGCACTGAAGGGGAGAGCTACACAGATCAGCAACATGCCCTTTATGGACGAGTCCTCTGGGTCTGACGATGACTGCAGCTC
TCAGGCGAGTTTCCGAATCTCGGTCCCCTCCTCTGAGTCCAGGAAGACCAGCGGACTAGGCAGCCCCCGGGCCATCAAGAGAGGCGTCTC
CATGTCCTCACTGAGCTCCGAGGGTGACTACGCCATCCCCCCGGACGCCTGCTCACTGGACAGTGACTACTCAGAGCCTGAGCACAAACT
GCAGCGCACCTCATCCTACTCCACCGACGGGCTGGGCCTGGGCGGGGAGTCACTGGAGAAGTCGGGCTACCTGCTGAAAATGGGGAGCCA
GGTGAAGACGTGGAAGAGGCGCTGGTTTGTCCTGAGACAGGGACAGATTATGTACTACAAGTCCCCGAGTGATGTCATCCGGAAACCTCA
AGGCCAAGTGGATCTGAACTCCCGCTGCCAAATTGTTCGAGGGGAGGGTTCACAGACGTTTCAGCTCATCTCTGAGAAGAAAACCTACTA
CCTGACGGCCGATTCACCCAGCCTGCTGGAGGAGTGGATCCGAGTACTCCAGAGCCTGCTGAAGGTGCAGGCCACCGGGCCTCCAGCTCT
GCTTCGGGGTGGCACCAAGCCCACCGTGAAGGGCTGGCTGACCAAGGTAAAGCATGGCCACTCCAAGGTGGTCTGGTGCGCTCTTGTTGG
GAAAATCTTCTACTACTATCGGAGCCATGAGGACAAGCGACCCCTGGGCTGCCTGCCTGTGCGGGATGCGCACATAGAGGAAGTAGATCG
ATCCTGTGACTCAGACGAGGACTATGAGGCTGGAGGAACCAGACGGTTGCTTTCCTCCCACTGCACCCTGGTGATCCACCCCACAGAGCA
CAGCCCCACCTACCTCCTCATTGGCACCAAGCATGAAAAGGATACGTGGCTCTACCACCTCACAGTGGCTGCAGGTGGCAGCAGTGCCAA
GGTGGGCACTGCCTATGAGCAGCTCATTGGAAAACTGATGGATGGTGAAGGAGATCCAGATTCGCCGCTCTGGAGGCACCCCATGCTGTG
CTACAGCAAAGACGGCCTATACGCCTCCCTCACCACCCTGCCCTCTGAGGCCTTGCAGACGGAGGCCCTCAAGCTCTTCAAGTCCTGCCA
GCTCTTCATCAACGTGCCGGTGGAAGCTGCCTCGGTGGACTACCATGTGTCCCTGGCCCAGACCGCACTGCAGGTCTGCCTGGTTCACCC
CGAGCTGCAGAGTGAGATCTACTGCCAACTCATGAAGCAGACCAGCTGCCGCCCACCTCAGAAGTACTCCCTCATGCAGTGCTGGCAGCT
CCTCGCTCTGTGTGCTCCACTTTTCCTGCCTCAGCATCACTTCCTCTGGTATGTCAAGCAGCAGCTCCAACGCCATGCAGATCCCAGAAG
TGAAACTGGCCAGTATGCCACCTACTGCCAGCGGGCAGTGGAGCGGACCCTGCGGACCGGGGAGCGGGAAGCCAGGCCATCGCGCATGGA
AGTGGTGTCCATCCTGCTGCGTAACCCCTTCCACCACTCCTTGCCCTTCAGCATCCCCGTGCACTTTACCAACGGGACTTACCATGTGGT
TGGTTTTGACGGCTCTTCCACGGTTGATGAGTTCCTCCAGCGGCTGAACCAGGAGATAGGCATGAGAAAGCCATCCCACTCTGGCTTTGC
CCTCTTCACGGACGATCCCTCGGGCAGGGACCTGGAGCACTGCCTGCAGGGAAGTGTCAAGATCTGTGATGCCATCTCCAAGTGGGAACA
AGCCATGAAGGAGCTGCACCCCGGAAAGTCTGAGGGTGGGACACGCGTCGTGAAGCTGATGTACAAGAACAGGCTGTACTTTCGCAGTCA
AGTCAAAGGGGAGACGGACCGAGAACGGCTGCTCCTTGCCTCTCAAACCAGTAGAGAGATAGTGGCAGGGAGGTTTCCTATCAACAAGGA
ATTGGCTCTTGAGATGGCTGCCCTGATGGCCCAGGTAGAATATGGGGACTTGGAGAAGCCTGCCCTGCCAGGCCCTGGAGGCACATCCCC
TGCCAAGGCTCAGCATCTTCTCCAGCAGGTCCTAGACAGGTTCCACCCCAGGCGCTATAGACATGGGGCCCCCGCTGAACAGCTGAGGCA
CCTGGCAGATATGTTGACCACAAAATGGGCAACATTGCAAGGATGCTCCCCTCCTGAGTGCATCCGCATCTACCTGACCGTGGCCAGGAA
ATGGCCTTTCTTTGGTGCTAAACTTTTTGCTGCTCAGCCTGCCCAGCTGTCTTCCAAGGAGAACGCTCTGGTGTGGATTGCTGTGAATGA
GGATGGCGTCAGCATCCTGGACCACAACACTATGCAAGTGCACATCACTTACCCCTACTCTTCAGTGACAACGTTTGGTGGCTGCAGGGA
TGACTTCATGCTTGTGATTAGATCTATCCCAGACAAGAGCTCTGGAAAAAGCCACATTGAGAAGTTGATCTTCCGGATGGCTGCTCCCAA
GATTGCAGAAGCTACCTTCATCATGGCCAGCTATATGAACCATTGCACTACAACTGTGAACCCCCCCACCAACCCACCCGGAGCCTGCCA
GCTGTGGGAACTGGATGGACGACAGTTCTTTTCTTCTGTTTCCTGTGCTACCAAGGGGCCAACGTTGCTGTGAATATTTCTCCTACCCGA
TTCCCCAACACCACTAGTGCCTCTGGATTTAGAGATATATATCCTAGGGTATGATACTACTGTGACGGGTCTAACAGCCCCCGGCTACTC
TTGTTCTGTGAAATGTGTATTTTAGTCTCTGTGAAGCCTTTACTCTCTAGGTGCCTTATAATGTTTCAGGGCTCAACTTTTTAAAATCCA
GACCCAGTGTTAAAACCATTTATTCCTTTTTTCATAAGAATAATGACTCCAGATGCTACCTGATTCTAGACATAGACAGGGATGATCCAC
TGTTACTGAGGGCATCAGTGCTATAAGTTAAGGCTTTCTGCACTGGTACTCTCAAGGAAGCTAATTTTCTTTCTGGGGGGGGCGGGGGAC
ACAGTGTCACTATGTCACCCAGTCCACAGGGTTCAAGCAATTCTCCTGCCTCAGCCTTCGGAGTGGCTGGGATTACAGGTGTGCGCCACC
ATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCTGC
CCACTTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATCGCCCAGCCCAGAAGCTAATTTTTTAATATTGTATATGGTCTTATT
TATACTTGAAGTTTTGTGAACGTCGCTAAACAGGATAGGACTAAAATTTCCAATTCTCCTACACTCTGTCAGAAGCCTAGAACTCACTAA
ACTGGGCTGCCTTTCCCAAATGGGAAAGGTGCTGACAGAGTTGGAGAAAAAAGAATAGACTCATTTTTCCCCATTATTGGTATGTAGGCA
TTGGTACAGCCCCTTCTGGGGCAGTCTTTGCAGGATAACATGCTATACCTGCTAAGATTCAAGCTGTTTTCCTCACACTGGACTTTAGGC
CAAACCCAGTACCACGCAATGTGCAAGCAAGGGCAGGAGGTAGGTCCAATCTGACCCCTCCCTGTCTCATTTTAATGACTGGACAGCGCT
CGGTGAAGGCTGTGTTCACTGTAGTGGGCCATCATTTGTTTCCTTCTTCTTGTAAAAGACCAAGCAAATGCACTCTGCTTTTTGCTGCTG
TAAGACCACCAAAAATGAGTCAGAAACACAGAAGACTATTTCAGGCATGTGGGCCTGGATATGCTCCTTGAGACTTCTGGCAAACTTCTG
CTGGGAATTAGTTTGAGGGTGAGGGTACATATGTGACATTTGCCCTAGCCTAAGAGTAGCAGGTAAAAAAAAGTTTCTTTCATCTTTTGC
CTTACTGATAATACCATAATCCCCCTCAATTCAGACCTTCTGATTGAGTGCAGAGGAGACTAGACAGTCTCCTCTAGACAGGTTGTAGAC
ACACCCTCCCCTAACAAAAACAAAACGAAAGAGTTCATACTCTGATTTTCCAACATCTAGGAAACTGAGTTTTATTTCCTAGCTCTAAGG
CAGCCTTACTATATGTCAGTAAAGTGCTGAAAACTGTATATTTAGCAGTAGCACCCAAAACCAAGCCTTTAACCCCAACAATGTGTGTAT
CTTTTGCACAGCAAAAACTGCGAGGCCAGAACTAGTTTATCTGAACACCTCAGCTGCTGTAAGCTTCTCCTCTCTCACCCCGTAAACTGA
CAAGCATGATGAAAAAAGAAGCACATCCAAGTTTCTGCCTCTTTTAAATGTACTTGACTTTGCAAGGCAAGTAGTTTTACAGCCATTTCT
GTTCACACTTTTCACCCCACAACTTGGGGATCTAGCTGAGACATTTCTACCTCGAACAAGTCACATGTACCACAGGTTCCTGAATAATTC
CTGCAGGGCTGGTGACAGACATAACAGCTCTGGTTTTATAATATCTTGGGTATCTCTAAGGCCAATAAGGATAACATTATCTACCCAGAG
AGTTTAGAAGAAAAGTAGGAGTCCAAAGGAAGAGTAAACAAGAATGGAGCTGTGTTCACACTGAATTTGGGGTCAATCTATTTCCCCCAC
CCTCTCTCCTCCCCAACCCTTCAGGAACCCTTTAGTTTATTAATCTTATACAGAAGAAACTAACTTAGAAACAAAGGATTCAATATTTGC
TTATTTATTCTTTGTTAACATGAGAGTCCCATGTCTGAAAACCAAAGTCCAATTTCTGTCTGGCCTTTTGTCTCATCCTTCTTGGCAAAA
GTAGCTTTTGAACTGATATAAAAAAAAATGCTGAGTAACAGAAAAGTATTAATGTGCTTGACACCATGACTGAAATACTATGATCTTGTT
TGTCAATAAAAAGCAGCTATCTGTGAACCAGGTAACTGTGTGTTTTGGAAGATCTGTTTATTAACAGTAAATAAATAAGCCCTGTACAGA

>27373_27373_2_ERG-PLEKHH1_ERG_chr21_39947586_ENST00000398919_PLEKHH1_chr14_68022542_ENST00000329153_length(amino acids)=1338AA_BP=16
MKDMIQTVPDPAAHIKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQM
RAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLVPPYGAAEQDSVPSEPGIQPMGQDSGS
QAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSSSSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPG
TKTSAREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSGLPELESRARSREEPEKMEMEEPPPAG
KNEERESPKALGAELEEVELGNKPPTPPLHQFSSWESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTAL
KGRATQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSS
YSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADS
PSLLEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVDRSCDSD
EDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDG
LYASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCA
PLFLPQHHFLWYVKQQLQRHADPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGS
STVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGET
DRERLLLASQTSREIVAGRFPINKELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADML
TTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ERG-PLEKHH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ERG-PLEKHH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ERG-PLEKHH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms7CTD_human
HgeneERGC0376358Malignant neoplasm of prostate7CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneERGC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneERGC0279980Extra-osseous Ewing's sarcoma1ORPHANET
HgeneERGC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human