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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ERG-RPS18 (FusionGDB2 ID:HG2078TG6222)

Fusion Gene Summary for ERG-RPS18

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG-RPS18
Fusion gene ID: hg2078tg6222
HgeneTgene
Gene symbol

ERG

RPS18

Gene ID

2078

6222

Gene nameETS transcription factor ERGribosomal protein S18
Synonymserg-3|p55D6S218E|HKE3|KE-3|KE3|S18
Cytomap('ERG')('RPS18')

21q22.2

6p21.32

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian40S ribosomal protein S18rhabdomyosarcoma antigen MU-RMS-40.21small ribosomal subunit protein uS13
Modification date2020032020200320
UniProtAcc

P11308

.
Ensembl transtripts involved in fusion geneENST00000398910, ENST00000398911, 
ENST00000398919, ENST00000417133, 
ENST00000442448, ENST00000398897, 
ENST00000485493, ENST00000288319, 
ENST00000398905, ENST00000398907, 
ENST00000429727, ENST00000453032, 
Fusion gene scores* DoF score19 X 16 X 5=15207 X 7 X 3=147
# samples 318
** MAII scorelog2(31/1520*10)=-2.29373120305671
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERG [Title/Abstract] AND RPS18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERG(39947586)-RPS18(33240405), # samples:2
ERG(39947585)-RPS18(33240404), # samples:2
Anticipated loss of major functional domain due to fusion event.ERG-RPS18 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-RPS18 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-RPS18 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ERG-RPS18 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ERG-RPS18 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ERG-RPS18 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826


check buttonFusion gene breakpoints across ERG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RPS18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-VN-A88L-01AERGchr21

39947586

-RPS18chr6

33240405

+
ChimerDB4PRADTCGA-VN-A88LERGchr21

39947585

-RPS18chr6

33240404

+
ChimerDB4PRADTCGA-VN-A88LERGchr21

39947586

-RPS18chr6

33240405

+


Top

Fusion Gene ORF analysis for ERG-RPS18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000398910ENST00000476222ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-3UTRENST00000398910ENST00000476222ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-3UTRENST00000398911ENST00000476222ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-3UTRENST00000398911ENST00000476222ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-3UTRENST00000398919ENST00000476222ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-3UTRENST00000398919ENST00000476222ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-3UTRENST00000417133ENST00000476222ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-3UTRENST00000417133ENST00000476222ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-3UTRENST00000442448ENST00000476222ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-3UTRENST00000442448ENST00000476222ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-5UTRENST00000398910ENST00000474973ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-5UTRENST00000398910ENST00000474973ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-5UTRENST00000398911ENST00000474973ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-5UTRENST00000398911ENST00000474973ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-5UTRENST00000398919ENST00000474973ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-5UTRENST00000398919ENST00000474973ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-5UTRENST00000417133ENST00000474973ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-5UTRENST00000417133ENST00000474973ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-5UTRENST00000442448ENST00000474973ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-5UTRENST00000442448ENST00000474973ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398910ENST00000211372ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398910ENST00000211372ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398910ENST00000434122ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398910ENST00000434122ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398910ENST00000440980ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398910ENST00000440980ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398910ENST00000454021ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398910ENST00000454021ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398910ENST00000457341ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398910ENST00000457341ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398910ENST00000470276ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398910ENST00000470276ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398910ENST00000476288ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398910ENST00000476288ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398910ENST00000476337ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398910ENST00000476337ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398910ENST00000477055ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398910ENST00000477055ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398910ENST00000484321ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398910ENST00000484321ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398910ENST00000486781ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398910ENST00000486781ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398910ENST00000494232ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398910ENST00000494232ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398910ENST00000497078ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398910ENST00000497078ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398911ENST00000211372ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398911ENST00000211372ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398911ENST00000434122ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398911ENST00000434122ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398911ENST00000440980ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398911ENST00000440980ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398911ENST00000454021ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398911ENST00000454021ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398911ENST00000457341ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398911ENST00000457341ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398911ENST00000470276ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398911ENST00000470276ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398911ENST00000476288ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398911ENST00000476288ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398911ENST00000476337ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398911ENST00000476337ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398911ENST00000477055ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398911ENST00000477055ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398911ENST00000484321ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398911ENST00000484321ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398911ENST00000486781ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398911ENST00000486781ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398911ENST00000494232ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398911ENST00000494232ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398911ENST00000497078ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398911ENST00000497078ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398919ENST00000211372ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398919ENST00000211372ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398919ENST00000434122ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398919ENST00000434122ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398919ENST00000440980ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398919ENST00000440980ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398919ENST00000454021ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398919ENST00000454021ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398919ENST00000457341ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398919ENST00000457341ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398919ENST00000470276ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398919ENST00000470276ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398919ENST00000476288ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398919ENST00000476288ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398919ENST00000476337ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398919ENST00000476337ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398919ENST00000477055ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398919ENST00000477055ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398919ENST00000484321ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398919ENST00000484321ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398919ENST00000486781ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398919ENST00000486781ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398919ENST00000494232ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398919ENST00000494232ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000398919ENST00000497078ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000398919ENST00000497078ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000417133ENST00000211372ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000417133ENST00000211372ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000417133ENST00000434122ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000417133ENST00000434122ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000417133ENST00000440980ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000417133ENST00000440980ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000417133ENST00000454021ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000417133ENST00000454021ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000417133ENST00000457341ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000417133ENST00000457341ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000417133ENST00000470276ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000417133ENST00000470276ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000417133ENST00000476288ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000417133ENST00000476288ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000417133ENST00000476337ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000417133ENST00000476337ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000417133ENST00000477055ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000417133ENST00000477055ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000417133ENST00000484321ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000417133ENST00000484321ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000417133ENST00000486781ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000417133ENST00000486781ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000417133ENST00000494232ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000417133ENST00000494232ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000417133ENST00000497078ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000417133ENST00000497078ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000442448ENST00000211372ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000442448ENST00000211372ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000442448ENST00000434122ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000442448ENST00000434122ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000442448ENST00000440980ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000442448ENST00000440980ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000442448ENST00000454021ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000442448ENST00000454021ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000442448ENST00000457341ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000442448ENST00000457341ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000442448ENST00000470276ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000442448ENST00000470276ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000442448ENST00000476288ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000442448ENST00000476288ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000442448ENST00000476337ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000442448ENST00000476337ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000442448ENST00000477055ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000442448ENST00000477055ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000442448ENST00000484321ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000442448ENST00000484321ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000442448ENST00000486781ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000442448ENST00000486781ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000442448ENST00000494232ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000442448ENST00000494232ERGchr21

39947585

-RPS18chr6

33240404

+
5CDS-intronENST00000442448ENST00000497078ERGchr21

39947586

-RPS18chr6

33240405

+
5CDS-intronENST00000442448ENST00000497078ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-3CDSENST00000398897ENST00000439602ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-3CDSENST00000398897ENST00000439602ERGchr21

39947585

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33240404

+
5UTR-3CDSENST00000485493ENST00000439602ERGchr21

39947586

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33240405

+
5UTR-3CDSENST00000485493ENST00000439602ERGchr21

39947585

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33240404

+
5UTR-3UTRENST00000398897ENST00000476222ERGchr21

39947586

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33240405

+
5UTR-3UTRENST00000398897ENST00000476222ERGchr21

39947585

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33240404

+
5UTR-3UTRENST00000485493ENST00000476222ERGchr21

39947586

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33240405

+
5UTR-3UTRENST00000485493ENST00000476222ERGchr21

39947585

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33240404

+
5UTR-5UTRENST00000398897ENST00000474973ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-5UTRENST00000398897ENST00000474973ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-5UTRENST00000485493ENST00000474973ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-5UTRENST00000485493ENST00000474973ERGchr21

39947585

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33240404

+
5UTR-intronENST00000398897ENST00000211372ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000398897ENST00000211372ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000398897ENST00000434122ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000398897ENST00000434122ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000398897ENST00000440980ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000398897ENST00000440980ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000398897ENST00000454021ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000398897ENST00000454021ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000398897ENST00000457341ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000398897ENST00000457341ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000398897ENST00000470276ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000398897ENST00000470276ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000398897ENST00000476288ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000398897ENST00000476288ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000398897ENST00000476337ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000398897ENST00000476337ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000398897ENST00000477055ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000398897ENST00000477055ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000398897ENST00000484321ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000398897ENST00000484321ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000398897ENST00000486781ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000398897ENST00000486781ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000398897ENST00000494232ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000398897ENST00000494232ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000398897ENST00000497078ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000398897ENST00000497078ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000485493ENST00000211372ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000485493ENST00000211372ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000485493ENST00000434122ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000485493ENST00000434122ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000485493ENST00000440980ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000485493ENST00000440980ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000485493ENST00000454021ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000485493ENST00000454021ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000485493ENST00000457341ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000485493ENST00000457341ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000485493ENST00000470276ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000485493ENST00000470276ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000485493ENST00000476288ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000485493ENST00000476288ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000485493ENST00000476337ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000485493ENST00000476337ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000485493ENST00000477055ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000485493ENST00000477055ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000485493ENST00000484321ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000485493ENST00000484321ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000485493ENST00000486781ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000485493ENST00000486781ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000485493ENST00000494232ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000485493ENST00000494232ERGchr21

39947585

-RPS18chr6

33240404

+
5UTR-intronENST00000485493ENST00000497078ERGchr21

39947586

-RPS18chr6

33240405

+
5UTR-intronENST00000485493ENST00000497078ERGchr21

39947585

-RPS18chr6

33240404

+
Frame-shiftENST00000398910ENST00000439602ERGchr21

39947586

-RPS18chr6

33240405

+
Frame-shiftENST00000398910ENST00000439602ERGchr21

39947585

-RPS18chr6

33240404

+
Frame-shiftENST00000417133ENST00000439602ERGchr21

39947586

-RPS18chr6

33240405

+
Frame-shiftENST00000417133ENST00000439602ERGchr21

39947585

-RPS18chr6

33240404

+
Frame-shiftENST00000442448ENST00000439602ERGchr21

39947586

-RPS18chr6

33240405

+
Frame-shiftENST00000442448ENST00000439602ERGchr21

39947585

-RPS18chr6

33240404

+
In-frameENST00000398911ENST00000439602ERGchr21

39947586

-RPS18chr6

33240405

+
In-frameENST00000398911ENST00000439602ERGchr21

39947585

-RPS18chr6

33240404

+
In-frameENST00000398919ENST00000439602ERGchr21

39947586

-RPS18chr6

33240405

+
In-frameENST00000398919ENST00000439602ERGchr21

39947585

-RPS18chr6

33240404

+
intron-3CDSENST00000288319ENST00000439602ERGchr21

39947586

-RPS18chr6

33240405

+
intron-3CDSENST00000288319ENST00000439602ERGchr21

39947585

-RPS18chr6

33240404

+
intron-3CDSENST00000398905ENST00000439602ERGchr21

39947586

-RPS18chr6

33240405

+
intron-3CDSENST00000398905ENST00000439602ERGchr21

39947585

-RPS18chr6

33240404

+
intron-3CDSENST00000398907ENST00000439602ERGchr21

39947586

-RPS18chr6

33240405

+
intron-3CDSENST00000398907ENST00000439602ERGchr21

39947585

-RPS18chr6

33240404

+
intron-3CDSENST00000429727ENST00000439602ERGchr21

39947586

-RPS18chr6

33240405

+
intron-3CDSENST00000429727ENST00000439602ERGchr21

39947585

-RPS18chr6

33240404

+
intron-3CDSENST00000453032ENST00000439602ERGchr21

39947586

-RPS18chr6

33240405

+
intron-3CDSENST00000453032ENST00000439602ERGchr21

39947585

-RPS18chr6

33240404

+
intron-3UTRENST00000288319ENST00000476222ERGchr21

39947586

-RPS18chr6

33240405

+
intron-3UTRENST00000288319ENST00000476222ERGchr21

39947585

-RPS18chr6

33240404

+
intron-3UTRENST00000398905ENST00000476222ERGchr21

39947586

-RPS18chr6

33240405

+
intron-3UTRENST00000398905ENST00000476222ERGchr21

39947585

-RPS18chr6

33240404

+
intron-3UTRENST00000398907ENST00000476222ERGchr21

39947586

-RPS18chr6

33240405

+
intron-3UTRENST00000398907ENST00000476222ERGchr21

39947585

-RPS18chr6

33240404

+
intron-3UTRENST00000429727ENST00000476222ERGchr21

39947586

-RPS18chr6

33240405

+
intron-3UTRENST00000429727ENST00000476222ERGchr21

39947585

-RPS18chr6

33240404

+
intron-3UTRENST00000453032ENST00000476222ERGchr21

39947586

-RPS18chr6

33240405

+
intron-3UTRENST00000453032ENST00000476222ERGchr21

39947585

-RPS18chr6

33240404

+
intron-5UTRENST00000288319ENST00000474973ERGchr21

39947586

-RPS18chr6

33240405

+
intron-5UTRENST00000288319ENST00000474973ERGchr21

39947585

-RPS18chr6

33240404

+
intron-5UTRENST00000398905ENST00000474973ERGchr21

39947586

-RPS18chr6

33240405

+
intron-5UTRENST00000398905ENST00000474973ERGchr21

39947585

-RPS18chr6

33240404

+
intron-5UTRENST00000398907ENST00000474973ERGchr21

39947586

-RPS18chr6

33240405

+
intron-5UTRENST00000398907ENST00000474973ERGchr21

39947585

-RPS18chr6

33240404

+
intron-5UTRENST00000429727ENST00000474973ERGchr21

39947586

-RPS18chr6

33240405

+
intron-5UTRENST00000429727ENST00000474973ERGchr21

39947585

-RPS18chr6

33240404

+
intron-5UTRENST00000453032ENST00000474973ERGchr21

39947586

-RPS18chr6

33240405

+
intron-5UTRENST00000453032ENST00000474973ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000288319ENST00000211372ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000288319ENST00000211372ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000288319ENST00000434122ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000288319ENST00000434122ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000288319ENST00000440980ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000288319ENST00000440980ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000288319ENST00000454021ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000288319ENST00000454021ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000288319ENST00000457341ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000288319ENST00000457341ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000288319ENST00000470276ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000288319ENST00000470276ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000288319ENST00000476288ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000288319ENST00000476288ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000288319ENST00000476337ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000288319ENST00000476337ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000288319ENST00000477055ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000288319ENST00000477055ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000288319ENST00000484321ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000288319ENST00000484321ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000288319ENST00000486781ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000288319ENST00000486781ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000288319ENST00000494232ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000288319ENST00000494232ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000288319ENST00000497078ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000288319ENST00000497078ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398905ENST00000211372ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398905ENST00000211372ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398905ENST00000434122ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398905ENST00000434122ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398905ENST00000440980ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398905ENST00000440980ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398905ENST00000454021ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398905ENST00000454021ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398905ENST00000457341ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398905ENST00000457341ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398905ENST00000470276ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398905ENST00000470276ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398905ENST00000476288ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398905ENST00000476288ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398905ENST00000476337ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398905ENST00000476337ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398905ENST00000477055ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398905ENST00000477055ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398905ENST00000484321ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398905ENST00000484321ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398905ENST00000486781ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398905ENST00000486781ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398905ENST00000494232ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398905ENST00000494232ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398905ENST00000497078ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398905ENST00000497078ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398907ENST00000211372ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398907ENST00000211372ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398907ENST00000434122ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398907ENST00000434122ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398907ENST00000440980ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398907ENST00000440980ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398907ENST00000454021ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398907ENST00000454021ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398907ENST00000457341ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398907ENST00000457341ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398907ENST00000470276ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398907ENST00000470276ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398907ENST00000476288ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398907ENST00000476288ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398907ENST00000476337ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398907ENST00000476337ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398907ENST00000477055ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398907ENST00000477055ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398907ENST00000484321ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398907ENST00000484321ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398907ENST00000486781ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398907ENST00000486781ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398907ENST00000494232ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398907ENST00000494232ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000398907ENST00000497078ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000398907ENST00000497078ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000429727ENST00000211372ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000429727ENST00000211372ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000429727ENST00000434122ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000429727ENST00000434122ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000429727ENST00000440980ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000429727ENST00000440980ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000429727ENST00000454021ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000429727ENST00000454021ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000429727ENST00000457341ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000429727ENST00000457341ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000429727ENST00000470276ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000429727ENST00000470276ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000429727ENST00000476288ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000429727ENST00000476288ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000429727ENST00000476337ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000429727ENST00000476337ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000429727ENST00000477055ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000429727ENST00000477055ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000429727ENST00000484321ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000429727ENST00000484321ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000429727ENST00000486781ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000429727ENST00000486781ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000429727ENST00000494232ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000429727ENST00000494232ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000429727ENST00000497078ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000429727ENST00000497078ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000453032ENST00000211372ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000453032ENST00000211372ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000453032ENST00000434122ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000453032ENST00000434122ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000453032ENST00000440980ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000453032ENST00000440980ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000453032ENST00000454021ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000453032ENST00000454021ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000453032ENST00000457341ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000453032ENST00000457341ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000453032ENST00000470276ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000453032ENST00000470276ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000453032ENST00000476288ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000453032ENST00000476288ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000453032ENST00000476337ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000453032ENST00000476337ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000453032ENST00000477055ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000453032ENST00000477055ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000453032ENST00000484321ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000453032ENST00000484321ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000453032ENST00000486781ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000453032ENST00000486781ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000453032ENST00000494232ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000453032ENST00000494232ERGchr21

39947585

-RPS18chr6

33240404

+
intron-intronENST00000453032ENST00000497078ERGchr21

39947586

-RPS18chr6

33240405

+
intron-intronENST00000453032ENST00000497078ERGchr21

39947585

-RPS18chr6

33240404

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000398911ERGchr2139947586-ENST00000439602RPS18chr633240405+688188140643167
ENST00000398919ERGchr2139947586-ENST00000439602RPS18chr633240405+834334286789167
ENST00000398911ERGchr2139947585-ENST00000439602RPS18chr633240404+688188140643167
ENST00000398919ERGchr2139947585-ENST00000439602RPS18chr633240404+834334286789167

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398911ENST00000439602ERGchr2139947586-RPS18chr633240405+0.0043225860.9956774
ENST00000398919ENST00000439602ERGchr2139947586-RPS18chr633240405+0.0055361130.99446386
ENST00000398911ENST00000439602ERGchr2139947585-RPS18chr633240404+0.0043225860.9956774
ENST00000398919ENST00000439602ERGchr2139947585-RPS18chr633240404+0.0055361130.99446386

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Fusion Genomic Features for ERG-RPS18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ERGchr2139947585-RPS18chr633240404+5.28E-091
ERGchr2139947585-RPS18chr633240404+5.28E-091
ERGchr2139947585-RPS18chr633240404+5.28E-091
ERGchr2139947585-RPS18chr633240404+5.28E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ERG-RPS18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:39947586/chr6:33240405)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

P11308

.
FUNCTION: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERGchr21:39947585chr6:33240404ENST00000288319-110311_3910480.0DNA bindingETS
HgeneERGchr21:39947585chr6:33240404ENST00000398897-29311_3910364.0DNA bindingETS
HgeneERGchr21:39947585chr6:33240404ENST00000398911-210311_39113463.0DNA bindingETS
HgeneERGchr21:39947585chr6:33240404ENST00000398919-312311_39113487.0DNA bindingETS
HgeneERGchr21:39947585chr6:33240404ENST00000417133-312311_39113487.0DNA bindingETS
HgeneERGchr21:39947585chr6:33240404ENST00000442448-311311_39113463.0DNA bindingETS
HgeneERGchr21:39947585chr6:33240404ENST00000453032-19311_3910388.0DNA bindingETS
HgeneERGchr21:39947586chr6:33240405ENST00000288319-110311_3910480.0DNA bindingETS
HgeneERGchr21:39947586chr6:33240405ENST00000398897-29311_3910364.0DNA bindingETS
HgeneERGchr21:39947586chr6:33240405ENST00000398911-210311_39113463.0DNA bindingETS
HgeneERGchr21:39947586chr6:33240405ENST00000398919-312311_39113487.0DNA bindingETS
HgeneERGchr21:39947586chr6:33240405ENST00000417133-312311_39113487.0DNA bindingETS
HgeneERGchr21:39947586chr6:33240405ENST00000442448-311311_39113463.0DNA bindingETS
HgeneERGchr21:39947586chr6:33240405ENST00000453032-19311_3910388.0DNA bindingETS
HgeneERGchr21:39947585chr6:33240404ENST00000288319-110113_1990480.0DomainPNT
HgeneERGchr21:39947585chr6:33240404ENST00000398897-29113_1990364.0DomainPNT
HgeneERGchr21:39947585chr6:33240404ENST00000398911-210113_19913463.0DomainPNT
HgeneERGchr21:39947585chr6:33240404ENST00000398919-312113_19913487.0DomainPNT
HgeneERGchr21:39947585chr6:33240404ENST00000417133-312113_19913487.0DomainPNT
HgeneERGchr21:39947585chr6:33240404ENST00000442448-311113_19913463.0DomainPNT
HgeneERGchr21:39947585chr6:33240404ENST00000453032-19113_1990388.0DomainPNT
HgeneERGchr21:39947586chr6:33240405ENST00000288319-110113_1990480.0DomainPNT
HgeneERGchr21:39947586chr6:33240405ENST00000398897-29113_1990364.0DomainPNT
HgeneERGchr21:39947586chr6:33240405ENST00000398911-210113_19913463.0DomainPNT
HgeneERGchr21:39947586chr6:33240405ENST00000398919-312113_19913487.0DomainPNT
HgeneERGchr21:39947586chr6:33240405ENST00000417133-312113_19913487.0DomainPNT
HgeneERGchr21:39947586chr6:33240405ENST00000442448-311113_19913463.0DomainPNT
HgeneERGchr21:39947586chr6:33240405ENST00000453032-19113_1990388.0DomainPNT


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Fusion Gene Sequence for ERG-RPS18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27374_27374_1_ERG-RPS18_ERG_chr21_39947585_ENST00000398911_RPS18_chr6_33240404_ENST00000439602_length(transcript)=688nt_BP=188nt
GTTATTCCAGGATCTTTGGAGACCCGAGGAAAGCCGTGTTGACCAAAAGCAAGACAAATGACTCACAGAGAAAAAAGATGGCAGAACCAA
GGGCAACTAAAGCCGTCAGGTTCTGAACAGCTGGTAGATGGGCTGGCTTACTGAAGGACATGATTCAGACTGTCCCGGACCCAGCAGCTC
ATATCAAGTCTCTAGTGATCCCTGAAAAGTTCCAGCATATTTTGCGAGTACTCAACACCAACATCGATGGGCGGCGGAAAATAGCCTTTG
CCATCACTGCCATTAAGGGTGTGGGCCGAAGATATGCTCATGTGGTGTTGAGGAAAGCAGACATTGACCTCACCAAGAGGGCGGGAGAAC
TCACTGAGGATGAGGTGGAACGTGTGATCACCATTATGCAGAATCCACGCCAGTACAAGATCCCAGACTGGTTCTTGAACAGACAGAAGG
ATGTAAAGGATGGAAAATACAGCCAGGTCCTAGCCAATGGTCTGGACAACAAGCTCCGTGAAGACCTGGAGCGACTGAAGAAGATTCGGG
CCCATAGAGGGCTGCGTCACTTCTGGGGCCTTCGTGTCCGAGGCCAGCACACCAAGACCACTGGCCGCCGTGGCCGCACCGTGGGTGTGT

>27374_27374_1_ERG-RPS18_ERG_chr21_39947585_ENST00000398911_RPS18_chr6_33240404_ENST00000439602_length(amino acids)=167AA_BP=16
MKDMIQTVPDPAAHIKSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVERVITIMQNPR

--------------------------------------------------------------
>27374_27374_2_ERG-RPS18_ERG_chr21_39947585_ENST00000398919_RPS18_chr6_33240404_ENST00000439602_length(transcript)=834nt_BP=334nt
GCTGAGCCCGTCGGCGCCGAGGGAGTTAGTGCGACCCGGCTCGGCGCGCACGGCCAAGGCACGCGCGCTGGCACACGCGGGCGCGGACAC
GCGCGGACACACACGTGCGGGACACGCCCTCCCCCGACGGCGGCGCTAACCTCTCGGTTATTCCAGGATCTTTGGAGACCCGAGGAAAGC
CGTGTTGACCAAAAGCAAGACAAATGACTCACAGAGAAAAAAGATGGCAGAACCAAGGGCAACTAAAGCCGTCAGGTTCTGAACAGCTGG
TAGATGGGCTGGCTTACTGAAGGACATGATTCAGACTGTCCCGGACCCAGCAGCTCATATCAAGTCTCTAGTGATCCCTGAAAAGTTCCA
GCATATTTTGCGAGTACTCAACACCAACATCGATGGGCGGCGGAAAATAGCCTTTGCCATCACTGCCATTAAGGGTGTGGGCCGAAGATA
TGCTCATGTGGTGTTGAGGAAAGCAGACATTGACCTCACCAAGAGGGCGGGAGAACTCACTGAGGATGAGGTGGAACGTGTGATCACCAT
TATGCAGAATCCACGCCAGTACAAGATCCCAGACTGGTTCTTGAACAGACAGAAGGATGTAAAGGATGGAAAATACAGCCAGGTCCTAGC
CAATGGTCTGGACAACAAGCTCCGTGAAGACCTGGAGCGACTGAAGAAGATTCGGGCCCATAGAGGGCTGCGTCACTTCTGGGGCCTTCG
TGTCCGAGGCCAGCACACCAAGACCACTGGCCGCCGTGGCCGCACCGTGGGTGTGTCCAAGAAGAAATAAGTCTGTAGGCCTTGTCTGTT

>27374_27374_2_ERG-RPS18_ERG_chr21_39947585_ENST00000398919_RPS18_chr6_33240404_ENST00000439602_length(amino acids)=167AA_BP=16
MKDMIQTVPDPAAHIKSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVERVITIMQNPR

--------------------------------------------------------------
>27374_27374_3_ERG-RPS18_ERG_chr21_39947586_ENST00000398911_RPS18_chr6_33240405_ENST00000439602_length(transcript)=688nt_BP=188nt
GTTATTCCAGGATCTTTGGAGACCCGAGGAAAGCCGTGTTGACCAAAAGCAAGACAAATGACTCACAGAGAAAAAAGATGGCAGAACCAA
GGGCAACTAAAGCCGTCAGGTTCTGAACAGCTGGTAGATGGGCTGGCTTACTGAAGGACATGATTCAGACTGTCCCGGACCCAGCAGCTC
ATATCAAGTCTCTAGTGATCCCTGAAAAGTTCCAGCATATTTTGCGAGTACTCAACACCAACATCGATGGGCGGCGGAAAATAGCCTTTG
CCATCACTGCCATTAAGGGTGTGGGCCGAAGATATGCTCATGTGGTGTTGAGGAAAGCAGACATTGACCTCACCAAGAGGGCGGGAGAAC
TCACTGAGGATGAGGTGGAACGTGTGATCACCATTATGCAGAATCCACGCCAGTACAAGATCCCAGACTGGTTCTTGAACAGACAGAAGG
ATGTAAAGGATGGAAAATACAGCCAGGTCCTAGCCAATGGTCTGGACAACAAGCTCCGTGAAGACCTGGAGCGACTGAAGAAGATTCGGG
CCCATAGAGGGCTGCGTCACTTCTGGGGCCTTCGTGTCCGAGGCCAGCACACCAAGACCACTGGCCGCCGTGGCCGCACCGTGGGTGTGT

>27374_27374_3_ERG-RPS18_ERG_chr21_39947586_ENST00000398911_RPS18_chr6_33240405_ENST00000439602_length(amino acids)=167AA_BP=16
MKDMIQTVPDPAAHIKSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVERVITIMQNPR

--------------------------------------------------------------
>27374_27374_4_ERG-RPS18_ERG_chr21_39947586_ENST00000398919_RPS18_chr6_33240405_ENST00000439602_length(transcript)=834nt_BP=334nt
GCTGAGCCCGTCGGCGCCGAGGGAGTTAGTGCGACCCGGCTCGGCGCGCACGGCCAAGGCACGCGCGCTGGCACACGCGGGCGCGGACAC
GCGCGGACACACACGTGCGGGACACGCCCTCCCCCGACGGCGGCGCTAACCTCTCGGTTATTCCAGGATCTTTGGAGACCCGAGGAAAGC
CGTGTTGACCAAAAGCAAGACAAATGACTCACAGAGAAAAAAGATGGCAGAACCAAGGGCAACTAAAGCCGTCAGGTTCTGAACAGCTGG
TAGATGGGCTGGCTTACTGAAGGACATGATTCAGACTGTCCCGGACCCAGCAGCTCATATCAAGTCTCTAGTGATCCCTGAAAAGTTCCA
GCATATTTTGCGAGTACTCAACACCAACATCGATGGGCGGCGGAAAATAGCCTTTGCCATCACTGCCATTAAGGGTGTGGGCCGAAGATA
TGCTCATGTGGTGTTGAGGAAAGCAGACATTGACCTCACCAAGAGGGCGGGAGAACTCACTGAGGATGAGGTGGAACGTGTGATCACCAT
TATGCAGAATCCACGCCAGTACAAGATCCCAGACTGGTTCTTGAACAGACAGAAGGATGTAAAGGATGGAAAATACAGCCAGGTCCTAGC
CAATGGTCTGGACAACAAGCTCCGTGAAGACCTGGAGCGACTGAAGAAGATTCGGGCCCATAGAGGGCTGCGTCACTTCTGGGGCCTTCG
TGTCCGAGGCCAGCACACCAAGACCACTGGCCGCCGTGGCCGCACCGTGGGTGTGTCCAAGAAGAAATAAGTCTGTAGGCCTTGTCTGTT

>27374_27374_4_ERG-RPS18_ERG_chr21_39947586_ENST00000398919_RPS18_chr6_33240405_ENST00000439602_length(amino acids)=167AA_BP=16
MKDMIQTVPDPAAHIKSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVERVITIMQNPR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ERG-RPS18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ERG-RPS18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ERG-RPS18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms7CTD_human
HgeneERGC0376358Malignant neoplasm of prostate7CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneERGC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneERGC0279980Extra-osseous Ewing's sarcoma1ORPHANET
HgeneERGC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human