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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ESR1-ASPH (FusionGDB2 ID:HG2099TG444)

Fusion Gene Summary for ESR1-ASPH

check button Fusion gene summary
Fusion gene informationFusion gene name: ESR1-ASPH
Fusion gene ID: hg2099tg444
HgeneTgene
Gene symbol

ESR1

ASPH

Gene ID

2099

444

Gene nameestrogen receptor 1aspartate beta-hydroxylase
SynonymsER|ESR|ESRA|ESTRR|Era|NR3A1AAH|BAH|CASQ2BP1|FDLAB|HAAH|JCTN|junctin
Cytomap('ESR1')('ASPH')

6q25.1-q25.2

8q12.3

Type of geneprotein-codingprotein-coding
Descriptionestrogen receptorE2 receptor alphaER-alphaestradiol receptorestrogen nuclear receptor alphaestrogen receptor alpha E1-E2-1-2estrogen receptor alpha E1-N2-E2-1-2nuclear receptor subfamily 3 group A member 1oestrogen receptor alphaaspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenase
Modification date2020032920200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000206249, ENST00000338799, 
ENST00000427531, ENST00000440973, 
ENST00000443427, ENST00000456483, 
ENST00000406599, ENST00000482101, 
Fusion gene scores* DoF score21 X 18 X 8=302417 X 17 X 5=1445
# samples 3519
** MAII scorelog2(35/3024*10)=-3.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1445*10)=-2.92699816905709
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ESR1 [Title/Abstract] AND ASPH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointESR1(152201906)-ASPH(62416068), # samples:4
Anticipated loss of major functional domain due to fusion event.ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneESR1

GO:0006366

transcription by RNA polymerase II

15831516

HgeneESR1

GO:0010629

negative regulation of gene expression

21695196

HgeneESR1

GO:0030520

intracellular estrogen receptor signaling pathway

9841876

HgeneESR1

GO:0032355

response to estradiol

15304487

HgeneESR1

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

7651415|16043358

HgeneESR1

GO:0043433

negative regulation of DNA-binding transcription factor activity

10816575

HgeneESR1

GO:0043627

response to estrogen

11581164

HgeneESR1

GO:0045893

positive regulation of transcription, DNA-templated

9841876|20074560

HgeneESR1

GO:0045899

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

9841876

HgeneESR1

GO:0045944

positive regulation of transcription by RNA polymerase II

11544182|12047722|15345745|15831516|18563714

HgeneESR1

GO:0051091

positive regulation of DNA-binding transcription factor activity

9328340|10681512

HgeneESR1

GO:0071392

cellular response to estradiol stimulus

15831516

TgeneASPH

GO:0045862

positive regulation of proteolysis

18387192

TgeneASPH

GO:0097202

activation of cysteine-type endopeptidase activity

18387192


check buttonFusion gene breakpoints across ESR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ASPH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A3KD-01AESR1chr6

152201905

+ASPHchr8

62416067

-
ChimerDB4BRCATCGA-A2-A3KD-01AESR1chr6

152201906

-ASPHchr8

62416068

-
ChimerDB4BRCATCGA-A2-A3KD-01AESR1chr6

152201906

+ASPHchr8

62416068

-
ChimerDB4BRCATCGA-A2-A3KDESR1chr6

152201906

+ASPHchr8

62416068

-


Top

Fusion Gene ORF analysis for ESR1-ASPH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000206249ENST00000356457ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000206249ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000379449ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000206249ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000389204ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000206249ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000445642ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000206249ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000517661ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000206249ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000517847ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000206249ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000517856ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000206249ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000517903ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000206249ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000518068ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000206249ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000522603ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000206249ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000522835ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000206249ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000522919ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000206249ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000523897ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000206249ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000356457ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000338799ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000379449ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000338799ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000389204ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000338799ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000445642ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000338799ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000517661ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000338799ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000517847ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000338799ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000517856ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000338799ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000517903ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000338799ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000518068ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000338799ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000522603ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000338799ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000522835ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000338799ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000522919ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000338799ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000523897ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000338799ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000356457ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000427531ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000379449ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000427531ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000389204ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000427531ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000445642ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000427531ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000517661ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000427531ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000517847ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000427531ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000517856ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000427531ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000517903ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000427531ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000518068ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000427531ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000522603ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000427531ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000522835ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000427531ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000522919ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000427531ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000523897ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000427531ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000356457ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000440973ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000379449ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000440973ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000389204ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000440973ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000445642ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000440973ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000517661ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000440973ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000517847ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000440973ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000517856ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000440973ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000517903ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000440973ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000518068ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000440973ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000522603ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000440973ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000522835ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000440973ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000522919ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000440973ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000523897ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000440973ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000356457ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000443427ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000379449ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000443427ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000389204ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000443427ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000445642ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000443427ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000517661ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000443427ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000517847ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000443427ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000517856ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000443427ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000517903ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000443427ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000518068ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000443427ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000522603ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000443427ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000522835ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000443427ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000522919ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000443427ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000523897ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000443427ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000356457ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000456483ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000379449ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000456483ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000389204ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000456483ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000445642ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000456483ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000517661ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000456483ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000517847ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000456483ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000517856ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000456483ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000517903ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000456483ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000518068ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000456483ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000522603ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000456483ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000522835ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000456483ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000522919ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000456483ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000523897ESR1chr6

152201905

+ASPHchr8

62416067

-
5CDS-intronENST00000456483ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
Frame-shiftENST00000206249ENST00000379454ESR1chr6

152201905

+ASPHchr8

62416067

-
Frame-shiftENST00000206249ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
Frame-shiftENST00000338799ENST00000379454ESR1chr6

152201905

+ASPHchr8

62416067

-
Frame-shiftENST00000338799ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
Frame-shiftENST00000427531ENST00000379454ESR1chr6

152201905

+ASPHchr8

62416067

-
Frame-shiftENST00000427531ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
Frame-shiftENST00000440973ENST00000379454ESR1chr6

152201905

+ASPHchr8

62416067

-
Frame-shiftENST00000440973ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
Frame-shiftENST00000443427ENST00000379454ESR1chr6

152201905

+ASPHchr8

62416067

-
Frame-shiftENST00000443427ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
Frame-shiftENST00000456483ENST00000379454ESR1chr6

152201905

+ASPHchr8

62416067

-
Frame-shiftENST00000456483ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
In-frameENST00000206249ENST00000541428ESR1chr6

152201905

+ASPHchr8

62416067

-
In-frameENST00000206249ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
In-frameENST00000338799ENST00000541428ESR1chr6

152201905

+ASPHchr8

62416067

-
In-frameENST00000338799ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
In-frameENST00000427531ENST00000541428ESR1chr6

152201905

+ASPHchr8

62416067

-
In-frameENST00000427531ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
In-frameENST00000440973ENST00000541428ESR1chr6

152201905

+ASPHchr8

62416067

-
In-frameENST00000440973ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
In-frameENST00000443427ENST00000541428ESR1chr6

152201905

+ASPHchr8

62416067

-
In-frameENST00000443427ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
In-frameENST00000456483ENST00000541428ESR1chr6

152201905

+ASPHchr8

62416067

-
In-frameENST00000456483ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-3CDSENST00000406599ENST00000379454ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-3CDSENST00000406599ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-3CDSENST00000406599ENST00000541428ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-3CDSENST00000406599ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-3CDSENST00000482101ENST00000379454ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-3CDSENST00000482101ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-3CDSENST00000482101ENST00000541428ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-3CDSENST00000482101ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000356457ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000406599ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000379449ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000406599ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000389204ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000406599ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000445642ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000406599ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000517661ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000406599ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000517847ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000406599ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000517856ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000406599ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000517903ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000406599ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000518068ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000406599ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000522603ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000406599ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000522835ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000406599ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000522919ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000406599ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000523897ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000406599ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000356457ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000482101ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000379449ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000482101ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000389204ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000482101ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000445642ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000482101ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000517661ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000482101ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000517847ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000482101ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000517856ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000482101ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000517903ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000482101ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000518068ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000482101ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000522603ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000482101ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000522835ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000482101ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000522919ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000482101ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000523897ESR1chr6

152201905

+ASPHchr8

62416067

-
intron-intronENST00000482101ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000440973ESR1chr6152201906+ENST00000541428ASPHchr862416068-408311303701212280
ENST00000338799ESR1chr6152201906+ENST00000541428ASPHchr862416068-5173222014602302280
ENST00000456483ESR1chr6152201906+ENST00000541428ASPHchr862416068-39319782181060280
ENST00000443427ESR1chr6152201906+ENST00000541428ASPHchr862416068-397410212611103280
ENST00000206249ESR1chr6152201906+ENST00000541428ASPHchr862416068-407511223621204280
ENST00000427531ESR1chr6152201906+ENST00000541428ASPHchr862416068-3426473205555116
ENST00000440973ESR1chr6152201905+ENST00000541428ASPHchr862416067-408311303701212280
ENST00000338799ESR1chr6152201905+ENST00000541428ASPHchr862416067-5173222014602302280
ENST00000456483ESR1chr6152201905+ENST00000541428ASPHchr862416067-39319782181060280
ENST00000443427ESR1chr6152201905+ENST00000541428ASPHchr862416067-397410212611103280
ENST00000206249ESR1chr6152201905+ENST00000541428ASPHchr862416067-407511223621204280
ENST00000427531ESR1chr6152201905+ENST00000541428ASPHchr862416067-3426473205555116

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000440973ENST00000541428ESR1chr6152201906+ASPHchr862416068-0.0011740210.99882597
ENST00000338799ENST00000541428ESR1chr6152201906+ASPHchr862416068-0.0009990050.99900097
ENST00000456483ENST00000541428ESR1chr6152201906+ASPHchr862416068-0.0009811840.9990188
ENST00000443427ENST00000541428ESR1chr6152201906+ASPHchr862416068-0.0010183430.99898165
ENST00000206249ENST00000541428ESR1chr6152201906+ASPHchr862416068-0.0009478880.9990521
ENST00000427531ENST00000541428ESR1chr6152201906+ASPHchr862416068-0.053744060.9462559
ENST00000440973ENST00000541428ESR1chr6152201905+ASPHchr862416067-0.0011740210.99882597
ENST00000338799ENST00000541428ESR1chr6152201905+ASPHchr862416067-0.0009990050.99900097
ENST00000456483ENST00000541428ESR1chr6152201905+ASPHchr862416067-0.0009811840.9990188
ENST00000443427ENST00000541428ESR1chr6152201905+ASPHchr862416067-0.0010183430.99898165
ENST00000206249ENST00000541428ESR1chr6152201905+ASPHchr862416067-0.0009478880.9990521
ENST00000427531ENST00000541428ESR1chr6152201905+ASPHchr862416067-0.053744060.9462559

Top

Fusion Genomic Features for ESR1-ASPH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ESR1-ASPH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:152201906/chr8:62416068)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38185_250253596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49185_250253596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510185_250253596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49185_250253596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48185_250253484.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38185_250253596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49185_250253596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510185_250253596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49185_250253596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48185_250253484.0DNA bindingNuclear receptor
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38185_205253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38221_245253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49185_205253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49221_245253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510185_205253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510221_245253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49185_205253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49221_245253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48185_205253484.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48221_245253484.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38185_205253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38221_245253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49185_205253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49221_245253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510185_205253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510221_245253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49185_205253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49221_245253596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48185_205253484.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48221_245253484.0Zinc fingerNR C4-type
TgeneASPHchr6:152201905chr8:62416067ENST0000035645701490_1020314.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST000003794490590_1020204.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST000003892040690_1020226.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST0000044564201690_1020651.6666666666666Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST0000051784701590_1020300.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST0000051790301590_1020299.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST0000051806801390_1020271.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST000005226030590_1020211.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST0000052283501490_1020257.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST0000035645701490_1020314.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST000003794490590_1020204.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST000003892040690_1020226.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST0000044564201690_1020651.6666666666666Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST0000051784701590_1020300.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST0000051790301590_1020299.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST0000051806801390_1020271.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST000005226030590_1020211.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST0000052283501490_1020257.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014111_3120314.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014323_3320314.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST000003564570149_290314.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905111_3120204.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905323_3320204.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST00000379449059_290204.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406111_3120226.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406323_3320226.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST00000389204069_290226.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016111_3120651.6666666666666Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016323_3320651.6666666666666Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST000004456420169_290651.6666666666666Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015111_3120300.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015323_3320300.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST000005178470159_290300.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015111_3120299.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015323_3320299.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST000005179030159_290299.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013111_3120271.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013323_3320271.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST000005180680139_290271.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305111_3120211.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305323_3320211.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST00000522603059_290211.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014111_3120257.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014323_3320257.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST000005228350149_290257.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014111_3120314.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014323_3320314.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST000003564570149_290314.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905111_3120204.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905323_3320204.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000379449059_290204.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406111_3120226.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406323_3320226.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000389204069_290226.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016111_3120651.6666666666666Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016323_3320651.6666666666666Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST000004456420169_290651.6666666666666Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015111_3120300.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015323_3320300.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST000005178470159_290300.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015111_3120299.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015323_3320299.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST000005179030159_290299.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013111_3120271.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013323_3320271.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST000005180680139_290271.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305111_3120211.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305323_3320211.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000522603059_290211.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014111_3120257.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014323_3320257.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST000005228350149_290257.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014688_6900314.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905688_6900204.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406688_6900226.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016688_6900651.6666666666666Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015688_6900300.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015688_6900299.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013688_6900271.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305688_6900211.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014688_6900257.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325688_690679730.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014688_6900314.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905688_6900204.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406688_6900226.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016688_6900651.6666666666666Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015688_6900300.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015688_6900299.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013688_6900271.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305688_6900211.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014688_6900257.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325688_690679730.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014341_3740314.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014454_4870314.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014489_5210314.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014525_5570314.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905341_3740204.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905454_4870204.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905489_5210204.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905525_5570204.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406341_3740226.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406454_4870226.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406489_5210226.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406525_5570226.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016341_3740651.6666666666666RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016454_4870651.6666666666666RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016489_5210651.6666666666666RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016525_5570651.6666666666666RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015341_3740300.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015454_4870300.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015489_5210300.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015525_5570300.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015341_3740299.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015454_4870299.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015489_5210299.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015525_5570299.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013341_3740271.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013454_4870271.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013489_5210271.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013525_5570271.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305341_3740211.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305454_4870211.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305489_5210211.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305525_5570211.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014341_3740257.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014454_4870257.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014489_5210257.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014525_5570257.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014341_3740314.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014454_4870314.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014489_5210314.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014525_5570314.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905341_3740204.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905454_4870204.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905489_5210204.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905525_5570204.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406341_3740226.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406454_4870226.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406489_5210226.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406525_5570226.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016341_3740651.6666666666666RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016454_4870651.6666666666666RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016489_5210651.6666666666666RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016525_5570651.6666666666666RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015341_3740300.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015454_4870300.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015489_5210300.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015525_5570300.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015341_3740299.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015454_4870299.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015489_5210299.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015525_5570299.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013341_3740271.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013454_4870271.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013489_5210271.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013525_5570271.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305341_3740211.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305454_4870211.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305489_5210211.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305525_5570211.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014341_3740257.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014454_4870257.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014489_5210257.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014525_5570257.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST000003564570141_530314.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST0000035645701475_7580314.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST00000379449051_530204.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST000003794490575_7580204.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST00000389204061_530226.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST000003892040675_7580226.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST000004456420161_530651.6666666666666Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST0000044564201675_7580651.6666666666666Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST000005178470151_530300.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST0000051784701575_7580300.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST000005179030151_530299.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST0000051790301575_7580299.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST000005180680131_530271.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST0000051806801375_7580271.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST00000522603051_530211.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST000005226030575_7580211.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST000005228350141_530257.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST0000052283501475_7580257.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST000003564570141_530314.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST0000035645701475_7580314.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000379449051_530204.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST000003794490575_7580204.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000389204061_530226.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST000003892040675_7580226.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST000004456420161_530651.6666666666666Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST0000044564201675_7580651.6666666666666Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST000005178470151_530300.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST0000051784701575_7580300.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST000005179030151_530299.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST0000051790301575_7580299.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST000005180680131_530271.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST0000051806801375_7580271.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000522603051_530211.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST000005226030575_7580211.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST000005228350141_530257.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST0000052283501475_7580257.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST0000035645701454_740314.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST000003794490554_740204.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST000003892040654_740226.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST0000044564201654_740651.6666666666666TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST0000051784701554_740300.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST0000051790301554_740299.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST0000051806801354_740271.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST000005226030554_740211.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST0000052283501454_740257.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST0000035645701454_740314.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST000003794490554_740204.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST000003892040654_740226.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST0000044564201654_740651.6666666666666TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST0000051784701554_740300.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST0000051790301554_740299.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST0000051806801354_740271.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST000005226030554_740211.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST0000052283501454_740257.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38311_547253596.0DomainNR LBD
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49311_547253596.0DomainNR LBD
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510311_547253596.0DomainNR LBD
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49311_547253596.0DomainNR LBD
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48311_547253484.0DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38311_547253596.0DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49311_547253596.0DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510311_547253596.0DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49311_547253596.0DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48311_547253484.0DomainNR LBD
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38251_310253596.0RegionNote=Hinge
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38264_595253596.0RegionNote=Self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38311_595253596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49251_310253596.0RegionNote=Hinge
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49264_595253596.0RegionNote=Self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49311_595253596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510251_310253596.0RegionNote=Hinge
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510264_595253596.0RegionNote=Self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510311_595253596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49251_310253596.0RegionNote=Hinge
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49264_595253596.0RegionNote=Self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49311_595253596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48251_310253484.0RegionNote=Hinge
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48264_595253484.0RegionNote=Self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48311_595253484.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38251_310253596.0RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38264_595253596.0RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38311_595253596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49251_310253596.0RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49264_595253596.0RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49311_595253596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510251_310253596.0RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510264_595253596.0RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510311_595253596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49251_310253596.0RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49264_595253596.0RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49311_595253596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48251_310253484.0RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48264_595253484.0RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48311_595253484.0RegionNote=Transactivation AF-2
TgeneASPHchr6:152201905chr8:62416067ENST00000379454232590_102708759.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST00000541428232590_102679730.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000379454232590_102708759.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000541428232590_102679730.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325111_312708759.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325323_332708759.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST0000037945423259_29708759.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325111_312679730.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325323_332679730.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST0000054142823259_29679730.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325111_312708759.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325323_332708759.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST0000037945423259_29708759.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325111_312679730.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325323_332679730.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST0000054142823259_29679730.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325688_690708759.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325688_690708759.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325341_374708759.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325454_487708759.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325489_521708759.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325525_557708759.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325341_374679730.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325454_487679730.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325489_521679730.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325525_557679730.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325341_374708759.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325454_487708759.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325489_521708759.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325525_557708759.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325341_374679730.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325454_487679730.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325489_521679730.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325525_557679730.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST0000037945423251_53708759.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST00000379454232575_758708759.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST0000054142823251_53679730.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST00000541428232575_758679730.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST0000037945423251_53708759.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000379454232575_758708759.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST0000054142823251_53679730.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000541428232575_758679730.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST00000379454232554_74708759.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST00000541428232554_74679730.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST00000379454232554_74708759.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST00000541428232554_74679730.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for ESR1-ASPH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27535_27535_1_ESR1-ASPH_ESR1_chr6_152201905_ENST00000206249_ASPH_chr8_62416067_ENST00000541428_length(transcript)=4075nt_BP=1122nt
GAGTTGTGCCTGGAGTGATGTTTAAGCCAATGTCAGGGCAAGGCAACAGTCCCTGGCCGTCCTCCAGCACCTTTGTAATGCATATGAGCT
CGGGAGACCAGTACTTAAAGTTGGAGGCCCGGGAGCCCAGGAGCTGGCGGAGGGCGTTCGTCCTGGGACTGCACTTGCTCCCGTCGGGTC
GCCCGGCTTCACCGGACCCGCAGGCTCCCGGGGCAGGGCCGGGGCCAGAGCTCGCGTGTCGGCGGGACATGCGCTGCGTCGCCTCTAACC
TCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGA
CCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGC
AGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCT
ACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCG
GCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTT
TCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCT
ACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCA
AGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCA
AGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCT
GCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCA
CGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCT
TCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGA
ATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATT
TGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTG
ATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAAACTGTGAA
TGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTACATTTTTGT
TTATTTTAATGACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCT
TCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAACTGTACCC
ATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAAAATCCTAT
TTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTTTTTTAATG
CCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGT
GTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAG
CCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGAT
GTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTC
TGCCATTTTAAACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATAGGTAAAAA
TCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAATCAAAGCTA
ACTAGGAATGTTAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATGGCACATAT
AGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAG
AACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGT
TCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTAAAATCGAG
AAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGCAATACAAT
TCAATGTTCATGTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTATAAGTCGTC
ATTTTTGAGCCATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATATGGTATTT
AAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAATAATTGAC
TCCAATAGCATTGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTCTTTATTTC
TCTTACCTATCTATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTGTGATTTCG
TATGTCTACACAAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTTATTTCTCC
AAGTGTATAATATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAGAGATGATG
TAATAAATAATTAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAGCTAACAAA
TTAACTCTCCCAAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGAGCACCAAC
TGGTAATACTAATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAACATGGCAC
AAGTAAGGATATCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCCATTTCTAAGGAGACTAGG
TAAATAAAATGACCTTTGACATTTC

>27535_27535_1_ESR1-ASPH_ESR1_chr6_152201905_ENST00000206249_ASPH_chr8_62416067_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST
RYGRMPHLSG

--------------------------------------------------------------
>27535_27535_2_ESR1-ASPH_ESR1_chr6_152201905_ENST00000338799_ASPH_chr8_62416067_ENST00000541428_length(transcript)=5173nt_BP=2220nt
CTAGAGCATGGGTGGCCATTGTTGACCTACAGGAGGCACCACTGTCACCAACAAAGGGTAACAGTCTTTCTTTTCAATATTTATTTATAT
CCAGTATTTATTTTCAATACTGACTATGGAGAGAGCTCTCCTGTGCTCAAACACTGCAATACTGGGGGTCTTTCAAAGCACAAAAACATA
TATTTGCATGATGGCATCATTAACATTTTTATGGCTTTCTATTTCTTTTTTGTACTGGTCTCAAGAGCCACTCATAAATCTCTCAGTAAC
TGCATAGTGTCCCAGGGCCAGAGACCGGCCACTCCTGGCATTGTGATTAGAGTCATTTAATATCCAAGGTGGTGACTAATGTCTGGCAAC
AAAGCCTCCATTGGGTGTCATGTGTCCTGGGACCCTGAGCGTGGGCACTCTAGGAGCACCTCAGTATTGCGTGTTAGTACTATGGCCGAG
AGAATAGTTGAGAAAGTGGTCAAGAGGTGGATCCATGTGAACGCCACTGGGAAATGAGAGACCTCGTTCCCAATCACGGTCAGTGCAACT
CGAAAGCCTAAAATCAGTTTAAAACAAAGGTATCTACCTTTATCTTATGTTCATATCCTAGGCTTTTAATAATACGTATTTTTCACATGT
TTACAGAAAGCAGTCAACTGAGCTATTCATGGAAAGGTTTGTGGGTTTGGTTAACGAAGTGGAGGAGTATTACATTTCAGCTGGAAACAC
ATCCCTAGAATGCCAAAACATTTATTCCAAAGTCTGGTTTCCTGGTGCAATCGGAGGCATGGCAATGCCTCTGTTCAGAGACTGGGGGCT
AGGGCCAGTAAGGCATTTGATCCACATGTATCCCAGAAGGCTTTTATTGTTAAATTATATTCTTTCGGAAAAACCACCCATGTCCTATTT
TGTAAACTTGATATCCATACACTTTTGACTGGCATTCTATTTTAGCCGTAAGACTATGATTCACAGCAAGCCTGTTTTTCCTCTTGCTTG
GGGTGGCAGCAGAAAGCATAGGGTACTTTCCAGCCTCCAAGGGTAGGGGCAAAGGGGCTGGGGTTTCTCCTCCCCAGTACAGCTTTCTCT
GGCTGTGCCACACTGCTCCCTGTGAGCAGACAGCAAGTCTCCCCTCACTCCCCACTGCCATTCATCCAGCGCTGTGCAGTAGCCCAGCTG
CGTGTCTGCCGGGAGGGGCTGCCAAGTGCCCTGCCTACTGGCTGCTTCCCGAATCCCTGCCATTCCACGCACAAACACATCCACACACTC
TCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGGCCCTTGACTTCTACAAGC
CCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCAC
CCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGG
AGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACT
ACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGT
CTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGC
CGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGG
CCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTA
TGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGG
GCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGA
GGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTT
TGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACC
ACAGCAGAGACGCAGCCTTCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTC
CTTGGGTGTGAGGATAGAATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAA
GACACTAAAGGGAATATTTGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGT
ATTTAAGGTGAACATTTGATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAAC
ATATGTAGAAACTGTGAATGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCAT
GTACCACTACATTTTTGTTTATTTTAATGACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGA
CTTCCCTCTTTTAATTCTTCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAG
TGTCTATGAACTGTACCCATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAG
ATATTGACAAAATCCTATTTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAG
ATGCAAATTTTTTTAATGCCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGG
ATAGGTGGCTGCTAGGGTGTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATC
CATGTGAATGTCAGGAAGCCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGT
TACCAAGAATGCCAGGATGTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTC
TCTGGCTTGAGAAATCTCTGCCATTTTAAACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACAT
AGAAATAATAGGTAAAAATCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTA
TATTTTGAATCAAAGCTAACTAGGAATGTTAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGC
TGCATGAATGGCACATATAGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTT
TCTTTATCTCATTTAAAGAACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTT
GCAAAATACTTTTCCTGTTCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAA
TTAATTACTAAAATCGAGAAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAAC
TGACAAGGGCAATACAATTCAATGTTCATGTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAA
TTCAAACTATAAGTCGTCATTTTTGAGCCATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGT
AAATATAATATGGTATTTAAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAA
GTGTTGTCAATAATTGACTCCAATAGCATTGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTC
ACTTCAATTCTTTATTTCTCTTACCTATCTATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTT
ATTATTTTTGTGATTTCGTATGTCTACACAAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTG
TTTCAACTTTATTTCTCCAAGTGTATAATATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCC
ATTGAGAAAGAGATGATGTAATAAATAATTAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTG
AATTATTTAGCTAACAAATTAACTCTCCCAAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGT
TTGACTTTGAGCACCAACTGGTAATACTAATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGG
TCTTGGAAAACATGGCACAAGTAAGGATATCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCC
ATTTCTAAGGAGACTAGGTAAATAAAATGACCTTTGACATTTC

>27535_27535_2_ESR1-ASPH_ESR1_chr6_152201905_ENST00000338799_ASPH_chr8_62416067_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST
RYGRMPHLSG

--------------------------------------------------------------
>27535_27535_3_ESR1-ASPH_ESR1_chr6_152201905_ENST00000427531_ASPH_chr8_62416067_ENST00000541428_length(transcript)=3426nt_BP=473nt
GCTTAAAAATAATCTCCTGCCAGCCCAGTGACAAGCCTGTCCCACCCGGGGAGAATGCCCCGGAGTGGCGTGCGGGTCAGCCAGGGTCTG
CGCCTCGCAGCCACTGTGGAAGGAGCGCGGCCGGTCCAGGACACAGGAGACCACTTTGTGACTTCAATGGCGAAGGCCAAATTCAGATAA
TCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGC
AGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACA
TAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTA
CGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCC
TCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTCCAGCAATTTAGCATGAA
TTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGAATTTCGAACACCAAGAGTC
AATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATTTGCCTCGCTGCAATTCATT
TAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTGATAGCTTCTACCTTACCAG
CCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAAACTGTGAATGGATTGCTTTAGTTTGTA
ATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTACATTTTTGTTTATTTTAATGACAAGCTG
TATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCTTCTTAGTAAAAGATACTCA
TGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAACTGTACCCATCCCAACTCTCAAATCGT
TTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAAAATCCTATTTCTTTCAAAGAGGAACTT
TTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTTTTTTAATGCCAATTATTAGAGCTTCTG
GGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGTGTCTGGCTCCTGGCGGCTT
TGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAGCCAGCTCTTCAGTCTTGGA
GATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGATGTTTTTCTTGGGCGTAGGA
GGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTCTGCCATTTTAAACATCACT
GTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATAGGTAAAAATCGTCTTGCCTACTCATTC
CAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAATCAAAGCTAACTAGGAATGTTAGATATA
AGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATGGCACATATAGGTCACCAAAGTTCATTC
ACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAGAACAGCTCTTTGAAATTGA
AATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGTTCTTTTGTTTTGCTGGTAT
TGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTAAAATCGAGAAGAGAAGGCAAACTCTTG
AAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGCAATACAATTCAATGTTCATGTAGTAAC
ATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTATAAGTCGTCATTTTTGAGCCATCATCTT
ACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATATGGTATTTAAAATCAGGTCACTACAGT
AAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAATAATTGACTCCAATAGCATTGTAAATA
CTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTCTTTATTTCTCTTACCTATCTATGTCTT
GGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTGTGATTTCGTATGTCTACACAAAAATGA
ATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTTATTTCTCCAAGTGTATAATATAAAAAT
TACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAGAGATGATGTAATAAATAATTAAGATTA
GTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAGCTAACAAATTAACTCTCCCAAATATTT
AAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGAGCACCAACTGGTAATACTAATAAATAC
CCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAACATGGCACAAGTAAGGATATCATATAT
GATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCCATTTCTAAGGAGACTAGGTAAATAAAATGACCTTTGA
CATTTC

>27535_27535_3_ESR1-ASPH_ESR1_chr6_152201905_ENST00000427531_ASPH_chr8_62416067_ENST00000541428_length(amino acids)=116AA_BP=89
MASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGG
PGRKARCSSLMTPLSTRYGRMPHLSG

--------------------------------------------------------------
>27535_27535_4_ESR1-ASPH_ESR1_chr6_152201905_ENST00000440973_ASPH_chr8_62416067_ENST00000541428_length(transcript)=4083nt_BP=1130nt
ATGGTCATAACAGCCTCCTGTCTACCGACTCAGAACGGATTTTACCAAAACTGAAAATGCAGGCTCCATGCTCAGAAGCTCTTTAACAGG
CTCGAAAGGTCCATGCTCCTTTCTCCTGCCCATTCTATAGCATAAGAAGACAGTCTCTGAGTGATAATCTTCTCTTCAAGAAGAAGAAAA
CTAGGAAGGAGTAAGCACAAAGATCTCTTCACATTCTCCGGGACTGCGGTACCAAATATCAGCACAGCACTTCTTGAAAAAGGATGTAGA
TTTTAATCTGAACTTTGAACCATCACTGAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCG
GCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAA
CCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGG
CGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGC
GGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCT
GTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCC
GGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGA
ATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGC
CTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTG
CCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCC
TTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGA
CGCAGCCTTCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTG
AGGATAGAATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAG
GGAATATTTGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTG
AACATTTGATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAA
ACTGTGAATGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTAC
ATTTTTGTTTATTTTAATGACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTT
TTAATTCTTCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAA
CTGTACCCATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAA
AATCCTATTTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTT
TTTTAATGCCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCT
GCTAGGGTGTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATG
TCAGGAAGCCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAAT
GCCAGGATGTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGA
GAAATCTCTGCCATTTTAAACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATA
GGTAAAAATCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAAT
CAAAGCTAACTAGGAATGTTAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATG
GCACATATAGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTC
ATTTAAAGAACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACT
TTTCCTGTTCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTA
AAATCGAGAAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGC
AATACAATTCAATGTTCATGTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTAT
AAGTCGTCATTTTTGAGCCATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATA
TGGTATTTAAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAA
TAATTGACTCCAATAGCATTGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTC
TTTATTTCTCTTACCTATCTATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTG
TGATTTCGTATGTCTACACAAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTT
ATTTCTCCAAGTGTATAATATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAG
AGATGATGTAATAAATAATTAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAG
CTAACAAATTAACTCTCCCAAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGA
GCACCAACTGGTAATACTAATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAA
CATGGCACAAGTAAGGATATCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCCATTTCTAAGG
AGACTAGGTAAATAAAATGACCTTTGACATTTC

>27535_27535_4_ESR1-ASPH_ESR1_chr6_152201905_ENST00000440973_ASPH_chr8_62416067_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST
RYGRMPHLSG

--------------------------------------------------------------
>27535_27535_5_ESR1-ASPH_ESR1_chr6_152201905_ENST00000443427_ASPH_chr8_62416067_ENST00000541428_length(transcript)=3974nt_BP=1021nt
GACAAACAGAGATATATCGGAGTCTGGCACGGGGCACATAAGGCAGCACATTAGAGAAAGCCGGCCCCTGGATCCGTCTTTCGCGTTTAT
TTTAAGCCCAGTCTTCCCTGGGCCACCTTTAGCAGATCCTCGTGCGCCCCCGCCCCCTGGCCGTGAAACTCAGCCTCTATCCAGCAGCGA
CGACAAGTAAAGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATG
ACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATC
CCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAAC
GCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGC
CTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCC
CACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAAT
TCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGC
TACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATT
CAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGT
AAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGC
AGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTCCAGCAATTT
AGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGAATTTCGAACAC
CAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATTTGCCTCGCTGC
AATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTGATAGCTTCTAC
CTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAAACTGTGAATGGATTGCTTT
AGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTACATTTTTGTTTATTTTAATG
ACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCTTCTTAGTAAAA
GATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAACTGTACCCATCCCAACTCT
CAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAAAATCCTATTTCTTTCAAAG
AGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTTTTTTAATGCCAATTATTAG
AGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGTGTCTGGCTCCT
GGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAGCCAGCTCTTCA
GTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGATGTTTTTCTTGG
GCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTCTGCCATTTTAA
ACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATAGGTAAAAATCGTCTTGCCT
ACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAATCAAAGCTAACTAGGAATGT
TAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATGGCACATATAGGTCACCAAA
GTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAGAACAGCTCTTT
GAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGTTCTTTTGTTTT
GCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTAAAATCGAGAAGAGAAGGCA
AACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGCAATACAATTCAATGTTCAT
GTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTATAAGTCGTCATTTTTGAGCC
ATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATATGGTATTTAAAATCAGGTC
ACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAATAATTGACTCCAATAGCAT
TGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTCTTTATTTCTCTTACCTATC
TATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTGTGATTTCGTATGTCTACAC
AAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTTATTTCTCCAAGTGTATAAT
ATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAGAGATGATGTAATAAATAAT
TAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAGCTAACAAATTAACTCTCCC
AAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGAGCACCAACTGGTAATACTA
ATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAACATGGCACAAGTAAGGATA
TCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCCATTTCTAAGGAGACTAGGTAAATAAAATG
ACCTTTGACATTTC

>27535_27535_5_ESR1-ASPH_ESR1_chr6_152201905_ENST00000443427_ASPH_chr8_62416067_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST
RYGRMPHLSG

--------------------------------------------------------------
>27535_27535_6_ESR1-ASPH_ESR1_chr6_152201905_ENST00000456483_ASPH_chr8_62416067_ENST00000541428_length(transcript)=3931nt_BP=978nt
AAACACATCCACACACTCTCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGG
CCCTTGACTTCTACAAGCCCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTG
CGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGA
TCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCA
AGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCC
TCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGC
TGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCG
GCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTA
CCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATG
GAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCA
CCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGA
AGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTG
GCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTG
CCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGAATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGC
CTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATTTGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAG
CACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTGATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAAT
TCAATGTATAATGAGAACATATGTAGAAACTGTGAATGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCT
AGACTATTTTGTCATCATGTACCACTACATTTTTGTTTATTTTAATGACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGC
ATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCTTCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGA
AAGAGCTCATTATGTCAGTGTCTATGAACTGTACCCATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTC
ACTATGCTAGTGGTGGAGATATTGACAAAATCCTATTTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATA
TTGTTATAAAAATCCCAGATGCAAATTTTTTTAATGCCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGT
TCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGTGTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGT
CTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAGCCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAG
GATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGATGTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTT
GGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTCTGCCATTTTAAACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTT
TAACATTACCCACAACATAGAAATAATAGGTAAAAATCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATT
CATGTATCAGATTTTGTATATTTTGAATCAAAGCTAACTAGGAATGTTAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGC
CAATATGAACAAAAATGCTGCATGAATGGCACATATAGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCT
AAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAGAACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAG
CTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGTTCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATG
GGAGGAAAAATATCCAAATTAATTACTAAAATCGAGAAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTA
TTGAACAGAGGAAATAACTGACAAGGGCAATACAATTCAATGTTCATGTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGT
ATATTGCATACACATAAATTCAAACTATAAGTCGTCATTTTTGAGCCATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAA
ACTAGCTCTTAACTTAGTAAATATAATATGGTATTTAAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAA
TGGTATTACTGTTGCAAAGTGTTGTCAATAATTGACTCCAATAGCATTGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATA
AAATGGATTTTCTAATTCACTTCAATTCTTTATTTCTCTTACCTATCTATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGG
TAGAATTATTTCAGTGTTATTATTTTTGTGATTTCGTATGTCTACACAAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGA
GAAATATTTTTAATTCTGTTTCAACTTTATTTCTCCAAGTGTATAATATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAA
AATTAAAACATTAGATCCATTGAGAAAGAGATGATGTAATAAATAATTAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTG
AATAATCTCTTTCCCTTGAATTATTTAGCTAACAAATTAACTCTCCCAAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTAT
TAACTAAAATATTTTTGTTTGACTTTGAGCACCAACTGGTAATACTAATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATG
TCTAAAAATATGCACTGGTCTTGGAAAACATGGCACAAGTAAGGATATCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAA
TGAGTAGTTGGGGACTCCATTTCTAAGGAGACTAGGTAAATAAAATGACCTTTGACATTTC

>27535_27535_6_ESR1-ASPH_ESR1_chr6_152201905_ENST00000456483_ASPH_chr8_62416067_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST
RYGRMPHLSG

--------------------------------------------------------------
>27535_27535_7_ESR1-ASPH_ESR1_chr6_152201906_ENST00000206249_ASPH_chr8_62416068_ENST00000541428_length(transcript)=4075nt_BP=1122nt
GAGTTGTGCCTGGAGTGATGTTTAAGCCAATGTCAGGGCAAGGCAACAGTCCCTGGCCGTCCTCCAGCACCTTTGTAATGCATATGAGCT
CGGGAGACCAGTACTTAAAGTTGGAGGCCCGGGAGCCCAGGAGCTGGCGGAGGGCGTTCGTCCTGGGACTGCACTTGCTCCCGTCGGGTC
GCCCGGCTTCACCGGACCCGCAGGCTCCCGGGGCAGGGCCGGGGCCAGAGCTCGCGTGTCGGCGGGACATGCGCTGCGTCGCCTCTAACC
TCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGA
CCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGC
AGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCT
ACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCG
GCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTT
TCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCT
ACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCA
AGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCA
AGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCT
GCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCA
CGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCT
TCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGA
ATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATT
TGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTG
ATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAAACTGTGAA
TGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTACATTTTTGT
TTATTTTAATGACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCT
TCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAACTGTACCC
ATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAAAATCCTAT
TTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTTTTTTAATG
CCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGT
GTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAG
CCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGAT
GTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTC
TGCCATTTTAAACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATAGGTAAAAA
TCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAATCAAAGCTA
ACTAGGAATGTTAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATGGCACATAT
AGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAG
AACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGT
TCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTAAAATCGAG
AAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGCAATACAAT
TCAATGTTCATGTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTATAAGTCGTC
ATTTTTGAGCCATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATATGGTATTT
AAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAATAATTGAC
TCCAATAGCATTGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTCTTTATTTC
TCTTACCTATCTATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTGTGATTTCG
TATGTCTACACAAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTTATTTCTCC
AAGTGTATAATATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAGAGATGATG
TAATAAATAATTAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAGCTAACAAA
TTAACTCTCCCAAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGAGCACCAAC
TGGTAATACTAATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAACATGGCAC
AAGTAAGGATATCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCCATTTCTAAGGAGACTAGG
TAAATAAAATGACCTTTGACATTTC

>27535_27535_7_ESR1-ASPH_ESR1_chr6_152201906_ENST00000206249_ASPH_chr8_62416068_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST
RYGRMPHLSG

--------------------------------------------------------------
>27535_27535_8_ESR1-ASPH_ESR1_chr6_152201906_ENST00000338799_ASPH_chr8_62416068_ENST00000541428_length(transcript)=5173nt_BP=2220nt
CTAGAGCATGGGTGGCCATTGTTGACCTACAGGAGGCACCACTGTCACCAACAAAGGGTAACAGTCTTTCTTTTCAATATTTATTTATAT
CCAGTATTTATTTTCAATACTGACTATGGAGAGAGCTCTCCTGTGCTCAAACACTGCAATACTGGGGGTCTTTCAAAGCACAAAAACATA
TATTTGCATGATGGCATCATTAACATTTTTATGGCTTTCTATTTCTTTTTTGTACTGGTCTCAAGAGCCACTCATAAATCTCTCAGTAAC
TGCATAGTGTCCCAGGGCCAGAGACCGGCCACTCCTGGCATTGTGATTAGAGTCATTTAATATCCAAGGTGGTGACTAATGTCTGGCAAC
AAAGCCTCCATTGGGTGTCATGTGTCCTGGGACCCTGAGCGTGGGCACTCTAGGAGCACCTCAGTATTGCGTGTTAGTACTATGGCCGAG
AGAATAGTTGAGAAAGTGGTCAAGAGGTGGATCCATGTGAACGCCACTGGGAAATGAGAGACCTCGTTCCCAATCACGGTCAGTGCAACT
CGAAAGCCTAAAATCAGTTTAAAACAAAGGTATCTACCTTTATCTTATGTTCATATCCTAGGCTTTTAATAATACGTATTTTTCACATGT
TTACAGAAAGCAGTCAACTGAGCTATTCATGGAAAGGTTTGTGGGTTTGGTTAACGAAGTGGAGGAGTATTACATTTCAGCTGGAAACAC
ATCCCTAGAATGCCAAAACATTTATTCCAAAGTCTGGTTTCCTGGTGCAATCGGAGGCATGGCAATGCCTCTGTTCAGAGACTGGGGGCT
AGGGCCAGTAAGGCATTTGATCCACATGTATCCCAGAAGGCTTTTATTGTTAAATTATATTCTTTCGGAAAAACCACCCATGTCCTATTT
TGTAAACTTGATATCCATACACTTTTGACTGGCATTCTATTTTAGCCGTAAGACTATGATTCACAGCAAGCCTGTTTTTCCTCTTGCTTG
GGGTGGCAGCAGAAAGCATAGGGTACTTTCCAGCCTCCAAGGGTAGGGGCAAAGGGGCTGGGGTTTCTCCTCCCCAGTACAGCTTTCTCT
GGCTGTGCCACACTGCTCCCTGTGAGCAGACAGCAAGTCTCCCCTCACTCCCCACTGCCATTCATCCAGCGCTGTGCAGTAGCCCAGCTG
CGTGTCTGCCGGGAGGGGCTGCCAAGTGCCCTGCCTACTGGCTGCTTCCCGAATCCCTGCCATTCCACGCACAAACACATCCACACACTC
TCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGGCCCTTGACTTCTACAAGC
CCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCAC
CCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGG
AGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACT
ACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGT
CTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGC
CGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGG
CCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTA
TGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGG
GCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGA
GGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTT
TGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACC
ACAGCAGAGACGCAGCCTTCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTC
CTTGGGTGTGAGGATAGAATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAA
GACACTAAAGGGAATATTTGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGT
ATTTAAGGTGAACATTTGATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAAC
ATATGTAGAAACTGTGAATGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCAT
GTACCACTACATTTTTGTTTATTTTAATGACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGA
CTTCCCTCTTTTAATTCTTCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAG
TGTCTATGAACTGTACCCATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAG
ATATTGACAAAATCCTATTTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAG
ATGCAAATTTTTTTAATGCCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGG
ATAGGTGGCTGCTAGGGTGTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATC
CATGTGAATGTCAGGAAGCCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGT
TACCAAGAATGCCAGGATGTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTC
TCTGGCTTGAGAAATCTCTGCCATTTTAAACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACAT
AGAAATAATAGGTAAAAATCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTA
TATTTTGAATCAAAGCTAACTAGGAATGTTAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGC
TGCATGAATGGCACATATAGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTT
TCTTTATCTCATTTAAAGAACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTT
GCAAAATACTTTTCCTGTTCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAA
TTAATTACTAAAATCGAGAAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAAC
TGACAAGGGCAATACAATTCAATGTTCATGTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAA
TTCAAACTATAAGTCGTCATTTTTGAGCCATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGT
AAATATAATATGGTATTTAAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAA
GTGTTGTCAATAATTGACTCCAATAGCATTGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTC
ACTTCAATTCTTTATTTCTCTTACCTATCTATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTT
ATTATTTTTGTGATTTCGTATGTCTACACAAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTG
TTTCAACTTTATTTCTCCAAGTGTATAATATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCC
ATTGAGAAAGAGATGATGTAATAAATAATTAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTG
AATTATTTAGCTAACAAATTAACTCTCCCAAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGT
TTGACTTTGAGCACCAACTGGTAATACTAATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGG
TCTTGGAAAACATGGCACAAGTAAGGATATCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCC
ATTTCTAAGGAGACTAGGTAAATAAAATGACCTTTGACATTTC

>27535_27535_8_ESR1-ASPH_ESR1_chr6_152201906_ENST00000338799_ASPH_chr8_62416068_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST
RYGRMPHLSG

--------------------------------------------------------------
>27535_27535_9_ESR1-ASPH_ESR1_chr6_152201906_ENST00000427531_ASPH_chr8_62416068_ENST00000541428_length(transcript)=3426nt_BP=473nt
GCTTAAAAATAATCTCCTGCCAGCCCAGTGACAAGCCTGTCCCACCCGGGGAGAATGCCCCGGAGTGGCGTGCGGGTCAGCCAGGGTCTG
CGCCTCGCAGCCACTGTGGAAGGAGCGCGGCCGGTCCAGGACACAGGAGACCACTTTGTGACTTCAATGGCGAAGGCCAAATTCAGATAA
TCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGC
AGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACA
TAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTA
CGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCC
TCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTCCAGCAATTTAGCATGAA
TTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGAATTTCGAACACCAAGAGTC
AATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATTTGCCTCGCTGCAATTCATT
TAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTGATAGCTTCTACCTTACCAG
CCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAAACTGTGAATGGATTGCTTTAGTTTGTA
ATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTACATTTTTGTTTATTTTAATGACAAGCTG
TATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCTTCTTAGTAAAAGATACTCA
TGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAACTGTACCCATCCCAACTCTCAAATCGT
TTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAAAATCCTATTTCTTTCAAAGAGGAACTT
TTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTTTTTTAATGCCAATTATTAGAGCTTCTG
GGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGTGTCTGGCTCCTGGCGGCTT
TGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAGCCAGCTCTTCAGTCTTGGA
GATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGATGTTTTTCTTGGGCGTAGGA
GGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTCTGCCATTTTAAACATCACT
GTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATAGGTAAAAATCGTCTTGCCTACTCATTC
CAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAATCAAAGCTAACTAGGAATGTTAGATATA
AGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATGGCACATATAGGTCACCAAAGTTCATTC
ACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAGAACAGCTCTTTGAAATTGA
AATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGTTCTTTTGTTTTGCTGGTAT
TGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTAAAATCGAGAAGAGAAGGCAAACTCTTG
AAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGCAATACAATTCAATGTTCATGTAGTAAC
ATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTATAAGTCGTCATTTTTGAGCCATCATCTT
ACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATATGGTATTTAAAATCAGGTCACTACAGT
AAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAATAATTGACTCCAATAGCATTGTAAATA
CTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTCTTTATTTCTCTTACCTATCTATGTCTT
GGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTGTGATTTCGTATGTCTACACAAAAATGA
ATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTTATTTCTCCAAGTGTATAATATAAAAAT
TACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAGAGATGATGTAATAAATAATTAAGATTA
GTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAGCTAACAAATTAACTCTCCCAAATATTT
AAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGAGCACCAACTGGTAATACTAATAAATAC
CCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAACATGGCACAAGTAAGGATATCATATAT
GATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCCATTTCTAAGGAGACTAGGTAAATAAAATGACCTTTGA
CATTTC

>27535_27535_9_ESR1-ASPH_ESR1_chr6_152201906_ENST00000427531_ASPH_chr8_62416068_ENST00000541428_length(amino acids)=116AA_BP=89
MASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGG
PGRKARCSSLMTPLSTRYGRMPHLSG

--------------------------------------------------------------
>27535_27535_10_ESR1-ASPH_ESR1_chr6_152201906_ENST00000440973_ASPH_chr8_62416068_ENST00000541428_length(transcript)=4083nt_BP=1130nt
ATGGTCATAACAGCCTCCTGTCTACCGACTCAGAACGGATTTTACCAAAACTGAAAATGCAGGCTCCATGCTCAGAAGCTCTTTAACAGG
CTCGAAAGGTCCATGCTCCTTTCTCCTGCCCATTCTATAGCATAAGAAGACAGTCTCTGAGTGATAATCTTCTCTTCAAGAAGAAGAAAA
CTAGGAAGGAGTAAGCACAAAGATCTCTTCACATTCTCCGGGACTGCGGTACCAAATATCAGCACAGCACTTCTTGAAAAAGGATGTAGA
TTTTAATCTGAACTTTGAACCATCACTGAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCG
GCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAA
CCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGG
CGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGC
GGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCT
GTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCC
GGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGA
ATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGC
CTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTG
CCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCC
TTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGA
CGCAGCCTTCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTG
AGGATAGAATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAG
GGAATATTTGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTG
AACATTTGATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAA
ACTGTGAATGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTAC
ATTTTTGTTTATTTTAATGACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTT
TTAATTCTTCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAA
CTGTACCCATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAA
AATCCTATTTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTT
TTTTAATGCCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCT
GCTAGGGTGTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATG
TCAGGAAGCCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAAT
GCCAGGATGTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGA
GAAATCTCTGCCATTTTAAACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATA
GGTAAAAATCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAAT
CAAAGCTAACTAGGAATGTTAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATG
GCACATATAGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTC
ATTTAAAGAACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACT
TTTCCTGTTCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTA
AAATCGAGAAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGC
AATACAATTCAATGTTCATGTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTAT
AAGTCGTCATTTTTGAGCCATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATA
TGGTATTTAAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAA
TAATTGACTCCAATAGCATTGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTC
TTTATTTCTCTTACCTATCTATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTG
TGATTTCGTATGTCTACACAAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTT
ATTTCTCCAAGTGTATAATATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAG
AGATGATGTAATAAATAATTAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAG
CTAACAAATTAACTCTCCCAAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGA
GCACCAACTGGTAATACTAATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAA
CATGGCACAAGTAAGGATATCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCCATTTCTAAGG
AGACTAGGTAAATAAAATGACCTTTGACATTTC

>27535_27535_10_ESR1-ASPH_ESR1_chr6_152201906_ENST00000440973_ASPH_chr8_62416068_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST
RYGRMPHLSG

--------------------------------------------------------------
>27535_27535_11_ESR1-ASPH_ESR1_chr6_152201906_ENST00000443427_ASPH_chr8_62416068_ENST00000541428_length(transcript)=3974nt_BP=1021nt
GACAAACAGAGATATATCGGAGTCTGGCACGGGGCACATAAGGCAGCACATTAGAGAAAGCCGGCCCCTGGATCCGTCTTTCGCGTTTAT
TTTAAGCCCAGTCTTCCCTGGGCCACCTTTAGCAGATCCTCGTGCGCCCCCGCCCCCTGGCCGTGAAACTCAGCCTCTATCCAGCAGCGA
CGACAAGTAAAGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATG
ACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATC
CCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAAC
GCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGC
CTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCC
CACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAAT
TCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGC
TACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATT
CAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGT
AAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGC
AGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTCCAGCAATTT
AGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGAATTTCGAACAC
CAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATTTGCCTCGCTGC
AATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTGATAGCTTCTAC
CTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAAACTGTGAATGGATTGCTTT
AGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTACATTTTTGTTTATTTTAATG
ACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCTTCTTAGTAAAA
GATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAACTGTACCCATCCCAACTCT
CAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAAAATCCTATTTCTTTCAAAG
AGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTTTTTTAATGCCAATTATTAG
AGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGTGTCTGGCTCCT
GGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAGCCAGCTCTTCA
GTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGATGTTTTTCTTGG
GCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTCTGCCATTTTAA
ACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATAGGTAAAAATCGTCTTGCCT
ACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAATCAAAGCTAACTAGGAATGT
TAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATGGCACATATAGGTCACCAAA
GTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAGAACAGCTCTTT
GAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGTTCTTTTGTTTT
GCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTAAAATCGAGAAGAGAAGGCA
AACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGCAATACAATTCAATGTTCAT
GTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTATAAGTCGTCATTTTTGAGCC
ATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATATGGTATTTAAAATCAGGTC
ACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAATAATTGACTCCAATAGCAT
TGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTCTTTATTTCTCTTACCTATC
TATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTGTGATTTCGTATGTCTACAC
AAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTTATTTCTCCAAGTGTATAAT
ATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAGAGATGATGTAATAAATAAT
TAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAGCTAACAAATTAACTCTCCC
AAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGAGCACCAACTGGTAATACTA
ATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAACATGGCACAAGTAAGGATA
TCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCCATTTCTAAGGAGACTAGGTAAATAAAATG
ACCTTTGACATTTC

>27535_27535_11_ESR1-ASPH_ESR1_chr6_152201906_ENST00000443427_ASPH_chr8_62416068_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST
RYGRMPHLSG

--------------------------------------------------------------
>27535_27535_12_ESR1-ASPH_ESR1_chr6_152201906_ENST00000456483_ASPH_chr8_62416068_ENST00000541428_length(transcript)=3931nt_BP=978nt
AAACACATCCACACACTCTCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGG
CCCTTGACTTCTACAAGCCCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTG
CGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGA
TCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCA
AGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCC
TCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGC
TGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCG
GCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTA
CCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATG
GAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCA
CCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGA
AGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTG
GCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTG
CCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGAATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGC
CTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATTTGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAG
CACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTGATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAAT
TCAATGTATAATGAGAACATATGTAGAAACTGTGAATGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCT
AGACTATTTTGTCATCATGTACCACTACATTTTTGTTTATTTTAATGACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGC
ATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCTTCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGA
AAGAGCTCATTATGTCAGTGTCTATGAACTGTACCCATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTC
ACTATGCTAGTGGTGGAGATATTGACAAAATCCTATTTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATA
TTGTTATAAAAATCCCAGATGCAAATTTTTTTAATGCCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGT
TCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGTGTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGT
CTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAGCCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAG
GATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGATGTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTT
GGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTCTGCCATTTTAAACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTT
TAACATTACCCACAACATAGAAATAATAGGTAAAAATCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATT
CATGTATCAGATTTTGTATATTTTGAATCAAAGCTAACTAGGAATGTTAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGC
CAATATGAACAAAAATGCTGCATGAATGGCACATATAGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCT
AAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAGAACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAG
CTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGTTCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATG
GGAGGAAAAATATCCAAATTAATTACTAAAATCGAGAAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTA
TTGAACAGAGGAAATAACTGACAAGGGCAATACAATTCAATGTTCATGTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGT
ATATTGCATACACATAAATTCAAACTATAAGTCGTCATTTTTGAGCCATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAA
ACTAGCTCTTAACTTAGTAAATATAATATGGTATTTAAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAA
TGGTATTACTGTTGCAAAGTGTTGTCAATAATTGACTCCAATAGCATTGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATA
AAATGGATTTTCTAATTCACTTCAATTCTTTATTTCTCTTACCTATCTATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGG
TAGAATTATTTCAGTGTTATTATTTTTGTGATTTCGTATGTCTACACAAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGA
GAAATATTTTTAATTCTGTTTCAACTTTATTTCTCCAAGTGTATAATATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAA
AATTAAAACATTAGATCCATTGAGAAAGAGATGATGTAATAAATAATTAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTG
AATAATCTCTTTCCCTTGAATTATTTAGCTAACAAATTAACTCTCCCAAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTAT
TAACTAAAATATTTTTGTTTGACTTTGAGCACCAACTGGTAATACTAATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATG
TCTAAAAATATGCACTGGTCTTGGAAAACATGGCACAAGTAAGGATATCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAA
TGAGTAGTTGGGGACTCCATTTCTAAGGAGACTAGGTAAATAAAATGACCTTTGACATTTC

>27535_27535_12_ESR1-ASPH_ESR1_chr6_152201906_ENST00000456483_ASPH_chr8_62416068_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST
RYGRMPHLSG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ESR1-ASPH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+3835_174253.33333333333334596.0DDX5%3B self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+4935_174253.33333333333334596.0DDX5%3B self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+51035_174253.33333333333334596.0DDX5%3B self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+4935_174253.33333333333334596.0DDX5%3B self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+4835_174253.33333333333334484.0DDX5%3B self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+3835_174253.33333333333334596.0DDX5%3B self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+4935_174253.33333333333334596.0DDX5%3B self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+51035_174253.33333333333334596.0DDX5%3B self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+4935_174253.33333333333334596.0DDX5%3B self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+4835_174253.33333333333334484.0DDX5%3B self-association


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48262_595253.33333333333334484.0AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48262_595253.33333333333334484.0AKAP13


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ESR1-ASPH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ESR1-ASPH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneESR1C0006142Malignant neoplasm of breast14CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneESR1C0678222Breast Carcinoma14CGI;CTD_human
HgeneESR1C1257931Mammary Neoplasms, Human14CTD_human
HgeneESR1C1458155Mammary Neoplasms14CTD_human
HgeneESR1C4704874Mammary Carcinoma, Human14CTD_human
HgeneESR1C0005586Bipolar Disorder5PSYGENET
HgeneESR1C0011570Mental Depression5PSYGENET
HgeneESR1C0011581Depressive disorder5PSYGENET
HgeneESR1C0036341Schizophrenia5PSYGENET
HgeneESR1C0525045Mood Disorders4PSYGENET
HgeneESR1C3809250ESTROGEN RESISTANCE3GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneESR1C0001418Adenocarcinoma2CTD_human
HgeneESR1C0007097Carcinoma2CTD_human
HgeneESR1C0007621Neoplastic Cell Transformation2CTD_human
HgeneESR1C0010054Coronary Arteriosclerosis2CTD_human
HgeneESR1C0021364Male infertility2CTD_human
HgeneESR1C0024121Lung Neoplasms2CTD_human
HgeneESR1C0024667Animal Mammary Neoplasms2CTD_human
HgeneESR1C0025500Mesothelioma2CTD_human
HgeneESR1C0027626Neoplasm Invasiveness2CTD_human
HgeneESR1C0033578Prostatic Neoplasms2CTD_human
HgeneESR1C0205641Adenocarcinoma, Basal Cell2CTD_human
HgeneESR1C0205642Adenocarcinoma, Oxyphilic2CTD_human
HgeneESR1C0205643Carcinoma, Cribriform2CTD_human
HgeneESR1C0205644Carcinoma, Granular Cell2CTD_human
HgeneESR1C0205645Adenocarcinoma, Tubular2CTD_human
HgeneESR1C0205696Anaplastic carcinoma2CTD_human
HgeneESR1C0205697Carcinoma, Spindle-Cell2CTD_human
HgeneESR1C0205698Undifferentiated carcinoma2CTD_human
HgeneESR1C0205699Carcinomatosis2CTD_human
HgeneESR1C0242379Malignant neoplasm of lung2CTD_human
HgeneESR1C0376358Malignant neoplasm of prostate2CTD_human
HgeneESR1C0848676Subfertility, Male2CTD_human
HgeneESR1C0917731Male sterility2CTD_human
HgeneESR1C1257925Mammary Carcinoma, Animal2CTD_human
HgeneESR1C1956346Coronary Artery Disease2CTD_human
HgeneESR1C2239176Liver carcinoma2CTD_human
HgeneESR1C0002395Alzheimer's Disease1CTD_human
HgeneESR1C0004114Astrocytoma1CTD_human
HgeneESR1C0004153Atherosclerosis1CTD_human
HgeneESR1C0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneESR1C0005695Bladder Neoplasm1CTD_human
HgeneESR1C0005940Bone Diseases1CTD_human
HgeneESR1C0005944Metabolic Bone Disorder1CTD_human
HgeneESR1C0007852Cervical Migraine Syndrome1CTD_human
HgeneESR1C0011265Presenile dementia1CTD_human
HgeneESR1C0014170Endometrial Neoplasms1CTD_human
HgeneESR1C0017658Glomerulonephritis1CTD_human
HgeneESR1C0018984Hemicrania migraine1CTD_human
HgeneESR1C0021361Female infertility1CTD_human
HgeneESR1C0023267Fibroid Tumor1CTD_human
HgeneESR1C0023418leukemia1CTD_human
HgeneESR1C0023903Liver neoplasms1CTD_human
HgeneESR1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneESR1C0024809Marijuana Abuse1PSYGENET
HgeneESR1C0026858Musculoskeletal Pain1CTD_human
HgeneESR1C0027051Myocardial Infarction1CTD_human
HgeneESR1C0027627Neoplasm Metastasis1CTD_human
HgeneESR1C0027643Neoplasm Recurrence, Local1CTD_human
HgeneESR1C0027819Neuroblastoma1CTD_human
HgeneESR1C0028754Obesity1CTD_human
HgeneESR1C0028960Oligospermia1CTD_human
HgeneESR1C0029453Osteopenia1CTD_human
HgeneESR1C0033937Psychoses, Drug1CTD_human
HgeneESR1C0033941Psychoses, Substance-Induced1CTD_human
HgeneESR1C0036939Shared Paranoid Disorder1PSYGENET
HgeneESR1C0038279Sterility, Postpartum1CTD_human
HgeneESR1C0042133Uterine Fibroids1CTD_human
HgeneESR1C0149931Migraine Disorders1CTD_human
HgeneESR1C0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneESR1C0235874Disease Exacerbation1CTD_human
HgeneESR1C0270858Abdominal Migraine1CTD_human
HgeneESR1C0276496Familial Alzheimer Disease (FAD)1CTD_human
HgeneESR1C0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneESR1C0280785Diffuse Astrocytoma1CTD_human
HgeneESR1C0282612Prostatic Intraepithelial Neoplasias1CTD_human
HgeneESR1C0334579Anaplastic astrocytoma1CTD_human
HgeneESR1C0334580Protoplasmic astrocytoma1CTD_human
HgeneESR1C0334581Gemistocytic astrocytoma1CTD_human
HgeneESR1C0334582Fibrillary Astrocytoma1CTD_human
HgeneESR1C0334583Pilocytic Astrocytoma1CTD_human
HgeneESR1C0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneESR1C0338489Status Migrainosus1CTD_human
HgeneESR1C0341869Subfertility, Female1CTD_human
HgeneESR1C0345904Malignant neoplasm of liver1CTD_human
HgeneESR1C0476089Endometrial Carcinoma1CGI;CTD_human
HgeneESR1C0494463Alzheimer Disease, Late Onset1CTD_human
HgeneESR1C0521664Acute Confusional Migraine1CTD_human
HgeneESR1C0546126Acute Confusional Senile Dementia1CTD_human
HgeneESR1C0547065Mixed oligoastrocytoma1CTD_human
HgeneESR1C0700438Sick Headaches1CTD_human
HgeneESR1C0750900Alzheimer's Disease, Focal Onset1CTD_human
HgeneESR1C0750901Alzheimer Disease, Early Onset1CTD_human
HgeneESR1C0750935Cerebral Astrocytoma1CTD_human
HgeneESR1C0750936Intracranial Astrocytoma1CTD_human
HgeneESR1C0917730Female sterility1CTD_human
HgeneESR1C1563937Atherogenesis1CTD_human
HgeneESR1C1704230Grade I Astrocytoma1CTD_human
HgeneESR1C1704377Bright Disease1CTD_human
HgeneESR1C1720887Female Urogenital Diseases1CTD_human
HgeneESR1C1800706Idiopathic Pulmonary Fibrosis1CTD_human
HgeneESR1C4721508Hamman-Rich Disease1CTD_human
HgeneESR1C4721509Usual Interstitial Pneumonia1CTD_human
HgeneESR1C4721952Familial Idiopathic Pulmonary Fibrosis1CTD_human
TgeneC1832167Ectopia Lentis, Spontaneous Filtering Blebs, and Craniofacial Dysmorphism1CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT