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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALAS1-SRPK2 (FusionGDB2 ID:HG211TG6733)

Fusion Gene Summary for ALAS1-SRPK2

check button Fusion gene summary
Fusion gene informationFusion gene name: ALAS1-SRPK2
Fusion gene ID: hg211tg6733
HgeneTgene
Gene symbol

ALAS1

SRPK2

Gene ID

211

6733

Gene name5'-aminolevulinate synthase 1SRSF protein kinase 2
SynonymsALAS|ALAS-H|ALAS3|ALASH|MIG4SFRSK2
Cytomap('ALAS1')('SRPK2')

3p21.2

7q22.3

Type of geneprotein-codingprotein-coding
Description5-aminolevulinate synthase, nonspecific, mitochondrial5-aminolevulinic acid synthase 1aminolevulinate, delta-, synthase 1delta-ALA synthase 1delta-aminolevulinate synthase 1migration-inducing protein 4SRSF protein kinase 2SFRS protein kinase 2SR protein kinase 2SR-protein-specific kinase 2serine kinase SRPK2serine/arginine-rich protein-specific kinase 2serine/arginine-rich splicing factor kinase 2serine/threonine-protein kinase SRPK2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000310271, ENST00000394965, 
ENST00000469224, ENST00000484952, 
Fusion gene scores* DoF score6 X 6 X 5=18013 X 13 X 5=845
# samples 613
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/845*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALAS1 [Title/Abstract] AND SRPK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALAS1(52238028)-SRPK2(104758469), # samples:1
Anticipated loss of major functional domain due to fusion event.ALAS1-SRPK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALAS1-SRPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ALAS1-SRPK2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ALAS1-SRPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ALAS1-SRPK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ALAS1-SRPK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ALAS1-SRPK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSRPK2

GO:0000245

spliceosomal complex assembly

9472028

TgeneSRPK2

GO:0006468

protein phosphorylation

9472028

TgeneSRPK2

GO:0008284

positive regulation of cell proliferation

18559500

TgeneSRPK2

GO:0008380

RNA splicing

9472028

TgeneSRPK2

GO:0035556

intracellular signal transduction

9472028

TgeneSRPK2

GO:0045070

positive regulation of viral genome replication

20498328

TgeneSRPK2

GO:0045071

negative regulation of viral genome replication

12417631


check buttonFusion gene breakpoints across ALAS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SRPK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8078-01AALAS1chr3

52238028

+SRPK2chr7

104758469

-


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Fusion Gene ORF analysis for ALAS1-SRPK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000310271ENST00000493638ALAS1chr3

52238028

+SRPK2chr7

104758469

-
5CDS-intronENST00000394965ENST00000493638ALAS1chr3

52238028

+SRPK2chr7

104758469

-
5CDS-intronENST00000469224ENST00000493638ALAS1chr3

52238028

+SRPK2chr7

104758469

-
5CDS-intronENST00000484952ENST00000493638ALAS1chr3

52238028

+SRPK2chr7

104758469

-
Frame-shiftENST00000310271ENST00000393651ALAS1chr3

52238028

+SRPK2chr7

104758469

-
Frame-shiftENST00000310271ENST00000489828ALAS1chr3

52238028

+SRPK2chr7

104758469

-
Frame-shiftENST00000394965ENST00000393651ALAS1chr3

52238028

+SRPK2chr7

104758469

-
Frame-shiftENST00000394965ENST00000489828ALAS1chr3

52238028

+SRPK2chr7

104758469

-
Frame-shiftENST00000469224ENST00000393651ALAS1chr3

52238028

+SRPK2chr7

104758469

-
Frame-shiftENST00000469224ENST00000489828ALAS1chr3

52238028

+SRPK2chr7

104758469

-
Frame-shiftENST00000484952ENST00000393651ALAS1chr3

52238028

+SRPK2chr7

104758469

-
Frame-shiftENST00000484952ENST00000489828ALAS1chr3

52238028

+SRPK2chr7

104758469

-
In-frameENST00000310271ENST00000357311ALAS1chr3

52238028

+SRPK2chr7

104758469

-
In-frameENST00000394965ENST00000357311ALAS1chr3

52238028

+SRPK2chr7

104758469

-
In-frameENST00000469224ENST00000357311ALAS1chr3

52238028

+SRPK2chr7

104758469

-
In-frameENST00000484952ENST00000357311ALAS1chr3

52238028

+SRPK2chr7

104758469

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000469224ALAS1chr352238028+ENST00000357311SRPK2chr7104758469-2425779196780194
ENST00000394965ALAS1chr352238028+ENST00000357311SRPK2chr7104758469-258393763938291
ENST00000310271ALAS1chr352238028+ENST00000357311SRPK2chr7104758469-236872225723232
ENST00000484952ALAS1chr352238028+ENST00000357311SRPK2chr7104758469-2544898315899194

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000469224ENST00000357311ALAS1chr352238028+SRPK2chr7104758469-0.0018374990.99816257
ENST00000394965ENST00000357311ALAS1chr352238028+SRPK2chr7104758469-0.0022980120.99770194
ENST00000310271ENST00000357311ALAS1chr352238028+SRPK2chr7104758469-0.0012188250.99878114
ENST00000484952ENST00000357311ALAS1chr352238028+SRPK2chr7104758469-0.0015854670.9984145

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Fusion Genomic Features for ALAS1-SRPK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ALAS1-SRPK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52238028/chr7:104758469)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSRPK2chr3:52238028chr7:104758469ENST00000357311131581_684627689.0DomainProtein kinase
TgeneSRPK2chr3:52238028chr7:104758469ENST00000393651141681_684638700.0DomainProtein kinase
TgeneSRPK2chr3:52238028chr7:104758469ENST00000489828151781_684627689.0DomainProtein kinase
TgeneSRPK2chr3:52238028chr7:104758469ENST00000357311131587_95627689.0Nucleotide bindingATP
TgeneSRPK2chr3:52238028chr7:104758469ENST00000393651141687_95638700.0Nucleotide bindingATP
TgeneSRPK2chr3:52238028chr7:104758469ENST00000489828151787_95627689.0Nucleotide bindingATP


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Fusion Gene Sequence for ALAS1-SRPK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3723_3723_1_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000310271_SRPK2_chr7_104758469_ENST00000357311_length(transcript)=2368nt_BP=722nt
ATATTAAGGCGCCGGCGATCGCGGCCTGAGGCTGCTCCCGGACAAGGGCAACGAGCGTTTCGTTTGGACTTCTCGACTTGAGTGCCCGCC
TCCTTCGCCGCCGCCTCTGCAGTCCTCAGCGCAGGAGCCAGCATACTTCCTGAACATGGAGAGTGTTGTTCGCCGCTGCCCATTCTTATC
CCGAGTCCCCCAGGCCTTTCTGCAGAAAGCAGGCAAATCTCTGTTGTTCTATGCCCAAAACTGCCCCAAGATGATGGAAGTTGGGGCCAA
GCCAGCCCCTCGGGCATTGTCCACTGCAGCAGTACACTACCAACAGATCAAAGAAACCCCTCCGGCCAGTGAGAAAGACAAAACTGCTAA
GGCCAAGGTCCAACAGACTCCTGATGGATCCCAGCAGAGTCCAGATGGCACACAGCTTCCGTCTGGACACCCCTTGCCTGCCACAAGCCA
GGGCACTGCAAGCAAATGCCCTTTCCTGGCAGCACAGATGAATCAGAGAGGCAGCAGTGTCTTCTGCAAAGCCAGTCTTGAGCTTCAGGA
GGATGTGCAGGAAATGAATGCCGTGAGGAAAGAGGTTGCTGAAACCTCAGCAGGCCCCAGTGTGGTTAGTGTGAAAACCGATGGAGGGGA
TCCCAGTGGACTGCTGAAGAACTTCCAGGACATCATGCAAAAGCAAAGACCAGAAAGAGTGTCTCATCTTCTTCAAGATAACTTGCCAAA
ATGAGAACTGCGACACATCACCAAGCTGAAGCCCTGGAGCCTCTTTGATGTACTTGTGGAAAAGTATGGCTGGCCCCATGAAGATGCTGC
ACAGTTTACAGATTTCCTGATCCCGATGTTAGAAATGGTTCCAGAAAAACGAGCCTCAGCTGGCGAATGCCTTCGGCATCCTTGGTTGAA
TTCTTAGCAAATTCTACCAATATTGCATTCTGAGCTAGCAAATGTTCCCAGTACATTGGACCTAAACGGTGACTCTCATTCTTTAACAGG
ATTACAAGTGAGCTGGCTTCATCCTCAGACCTTTATTTTGCTTTGAGGTACTGTTGTTTGACATTTTGCTTTTTGTGCACTGTGATCCTG
GGGAAGGGTAGTCTTTTGTCTTCAGCTAAGTAGTTTACTGACCATTTTCTTCTGGAAACAATAACATGTCTCTAAGCATTGTTTCTTGTG
TTGTGTGACATTCAAATGTCATTTTTTTGAATGAAAAATACTTTCCCCTTTGTGTTTTGGCAGGTTTTGTAACTATTTATGAAGAAATAT
TTTAGCTGAGTACTATATAATTTACAATCTTAAGAAATTATCAAGTTGGAACCAAGAAATAGCAAGGAAATGTACAATTTTATCTTCTGG
CAAAGGGACATCATTCCTGTATTATAGTGTATGTAAATGCACCCTGTAAATGTTACTTTCCATTAAATATGGGAGGGGGACTCAAATTTC
AGAAAAGCTACCAAGTCTTGAGTGCTTTGTAGCCTATGTTGCATGTAGCGGACTTTAACTGCTCCAAGGAGTTGTGCAAACTTTTCATTC
CATAACAGTCTTTTCACATTGGATTTTAAACAAAGTGGCTCTGGGTTATAAGATGTCATTCTCTATATGGCACTTTAAAGGAAGAAAAGA
TATGTTTCTCATTCTAAAATATGCATTATAATTTAGCAGTCCCATTTGTGATTTTGCATATTTTTAAAAGTACTTTTAAAGAAGAGCAAT
TTCCCTTTAAAAATGTGATGGCTCAGTACCATGTCATGTTGCCTCCTCTGGGCGCTGTAAGTTAAGCTCTACATAGATTAAATTGGAGAA
ACGTGTTAATTGTGTGGAATGAAAAAATACATATATTTTTGGAAAAGCATGATCATGCTTGTCTAGAACACAAGGTATGGTATATACAAT
TTGCAGTGCAGTGGGCAGAATACTTCTCACAGCTCAAAGATAACAGTGATCACATTCATTCCATAGGTAGCTTTACGTGTGGCTACAACA
AATTTTACTAGCTTTTTCATTGTCTTTCCATGAAACGAAGTTGAGAAAATGATTTTCCCTTTGCAGGTTGCACACAGTTTTGTTTATGCA
TTTCCTTAAAATTAATTGTAGACTCCAGGATACAAACCATAGTAGGCAATACAATTTTAGAATGTAATATATAGAGGTATATTTAGCCTC
TTTTAGAAGTCAGTGGATTGAATGTCTTTTTATTTTAAATTTTACATTCATTAAGGTGCCTCGTTTTTGACTTTGTCCATTAACATTTAT
CCATATGCCTTTGCAATAACTAGATTGTGAAAAGCTAACAAGTGTTGTAACAATAATCCATTGTTTGAGGTGCTTGCAGTTGTCTTAAAA

>3723_3723_1_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000310271_SRPK2_chr7_104758469_ENST00000357311_length(amino acids)=232AA_BP=
MRLLPDKGNERFVWTSRLECPPPSPPPLQSSAQEPAYFLNMESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALST
AAVHYQQIKETPPASEKDKTAKAKVQQTPDGSQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAV

--------------------------------------------------------------
>3723_3723_2_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000394965_SRPK2_chr7_104758469_ENST00000357311_length(transcript)=2583nt_BP=937nt
AGCGCCCAAGGCGCATGCGCAGCGGTCACTCCCGCTGTATATTAAGGCGCCGGCGATCGCGGCCTGAGGCTGCTCCCGGACAAGGGCAAC
GAGCGTTTCGTTTGGACTTCTCGACTTGAGTGCCCGCCTCCTTCGCCGCCGCCTCTGCAGTCCTCAGCGCAGTTATGCCCAGTTCTTCCC
GCTGTGGGGACACGACCACGGAGGAATCCTTGCTTCAGGGACTCGGGACCCTGCTGGACCCCTTCCTCGGGTTTAGGGGATGTGGGGACC
AGGAGAAAGTCAGGATCCCTAAGAGTCTTCCCTGCCTGGATGGATGAGTGGCTTCTTCTCCACCTAGATGAGCCAGCATACTTCCTGAAC
ATGGAGAGTGTTGTTCGCCGCTGCCCATTCTTATCCCGAGTCCCCCAGGCCTTTCTGCAGAAAGCAGGCAAATCTCTGTTGTTCTATGCC
CAAAACTGCCCCAAGATGATGGAAGTTGGGGCCAAGCCAGCCCCTCGGGCATTGTCCACTGCAGCAGTACACTACCAACAGATCAAAGAA
ACCCCTCCGGCCAGTGAGAAAGACAAAACTGCTAAGGCCAAGGTCCAACAGACTCCTGATGGATCCCAGCAGAGTCCAGATGGCACACAG
CTTCCGTCTGGACACCCCTTGCCTGCCACAAGCCAGGGCACTGCAAGCAAATGCCCTTTCCTGGCAGCACAGATGAATCAGAGAGGCAGC
AGTGTCTTCTGCAAAGCCAGTCTTGAGCTTCAGGAGGATGTGCAGGAAATGAATGCCGTGAGGAAAGAGGTTGCTGAAACCTCAGCAGGC
CCCAGTGTGGTTAGTGTGAAAACCGATGGAGGGGATCCCAGTGGACTGCTGAAGAACTTCCAGGACATCATGCAAAAGCAAAGACCAGAA
AGAGTGTCTCATCTTCTTCAAGATAACTTGCCAAAATGAGAACTGCGACACATCACCAAGCTGAAGCCCTGGAGCCTCTTTGATGTACTT
GTGGAAAAGTATGGCTGGCCCCATGAAGATGCTGCACAGTTTACAGATTTCCTGATCCCGATGTTAGAAATGGTTCCAGAAAAACGAGCC
TCAGCTGGCGAATGCCTTCGGCATCCTTGGTTGAATTCTTAGCAAATTCTACCAATATTGCATTCTGAGCTAGCAAATGTTCCCAGTACA
TTGGACCTAAACGGTGACTCTCATTCTTTAACAGGATTACAAGTGAGCTGGCTTCATCCTCAGACCTTTATTTTGCTTTGAGGTACTGTT
GTTTGACATTTTGCTTTTTGTGCACTGTGATCCTGGGGAAGGGTAGTCTTTTGTCTTCAGCTAAGTAGTTTACTGACCATTTTCTTCTGG
AAACAATAACATGTCTCTAAGCATTGTTTCTTGTGTTGTGTGACATTCAAATGTCATTTTTTTGAATGAAAAATACTTTCCCCTTTGTGT
TTTGGCAGGTTTTGTAACTATTTATGAAGAAATATTTTAGCTGAGTACTATATAATTTACAATCTTAAGAAATTATCAAGTTGGAACCAA
GAAATAGCAAGGAAATGTACAATTTTATCTTCTGGCAAAGGGACATCATTCCTGTATTATAGTGTATGTAAATGCACCCTGTAAATGTTA
CTTTCCATTAAATATGGGAGGGGGACTCAAATTTCAGAAAAGCTACCAAGTCTTGAGTGCTTTGTAGCCTATGTTGCATGTAGCGGACTT
TAACTGCTCCAAGGAGTTGTGCAAACTTTTCATTCCATAACAGTCTTTTCACATTGGATTTTAAACAAAGTGGCTCTGGGTTATAAGATG
TCATTCTCTATATGGCACTTTAAAGGAAGAAAAGATATGTTTCTCATTCTAAAATATGCATTATAATTTAGCAGTCCCATTTGTGATTTT
GCATATTTTTAAAAGTACTTTTAAAGAAGAGCAATTTCCCTTTAAAAATGTGATGGCTCAGTACCATGTCATGTTGCCTCCTCTGGGCGC
TGTAAGTTAAGCTCTACATAGATTAAATTGGAGAAACGTGTTAATTGTGTGGAATGAAAAAATACATATATTTTTGGAAAAGCATGATCA
TGCTTGTCTAGAACACAAGGTATGGTATATACAATTTGCAGTGCAGTGGGCAGAATACTTCTCACAGCTCAAAGATAACAGTGATCACAT
TCATTCCATAGGTAGCTTTACGTGTGGCTACAACAAATTTTACTAGCTTTTTCATTGTCTTTCCATGAAACGAAGTTGAGAAAATGATTT
TCCCTTTGCAGGTTGCACACAGTTTTGTTTATGCATTTCCTTAAAATTAATTGTAGACTCCAGGATACAAACCATAGTAGGCAATACAAT
TTTAGAATGTAATATATAGAGGTATATTTAGCCTCTTTTAGAAGTCAGTGGATTGAATGTCTTTTTATTTTAAATTTTACATTCATTAAG
GTGCCTCGTTTTTGACTTTGTCCATTAACATTTATCCATATGCCTTTGCAATAACTAGATTGTGAAAAGCTAACAAGTGTTGTAACAATA

>3723_3723_2_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000394965_SRPK2_chr7_104758469_ENST00000357311_length(amino acids)=291AA_BP=
MRLLPDKGNERFVWTSRLECPPPSPPPLQSSAQLCPVLPAVGTRPRRNPCFRDSGPCWTPSSGLGDVGTRRKSGSLRVFPAWMDEWLLLH
LDEPAYFLNMESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKETPPASEKDKTAKAKVQQTPDG
SQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQ

--------------------------------------------------------------
>3723_3723_3_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000469224_SRPK2_chr7_104758469_ENST00000357311_length(transcript)=2425nt_BP=779nt
AAGAAGGCAGCGCCCAAGGCGCATGCGCAGCGGTCACTCCCGCTGTATATTAAGGCGCCGGCGATCGCGGCCTGAGGCTGCTCCCGGACA
AGGGCAACGAGCGTTTCGTTTGGACTTCTCGACTTGAGTGCCCGCCTCCTTCGCCGCCGCCTCTGCAGTCCTCAGCGCAGTCTTTCCACA
GGAGCCAGCATACTTCCTGAACATGGAGAGTGTTGTTCGCCGCTGCCCATTCTTATCCCGAGTCCCCCAGGCCTTTCTGCAGAAAGCAGG
CAAATCTCTGTTGTTCTATGCCCAAAACTGCCCCAAGATGATGGAAGTTGGGGCCAAGCCAGCCCCTCGGGCATTGTCCACTGCAGCAGT
ACACTACCAACAGATCAAAGAAACCCCTCCGGCCAGTGAGAAAGACAAAACTGCTAAGGCCAAGGTCCAACAGACTCCTGATGGATCCCA
GCAGAGTCCAGATGGCACACAGCTTCCGTCTGGACACCCCTTGCCTGCCACAAGCCAGGGCACTGCAAGCAAATGCCCTTTCCTGGCAGC
ACAGATGAATCAGAGAGGCAGCAGTGTCTTCTGCAAAGCCAGTCTTGAGCTTCAGGAGGATGTGCAGGAAATGAATGCCGTGAGGAAAGA
GGTTGCTGAAACCTCAGCAGGCCCCAGTGTGGTTAGTGTGAAAACCGATGGAGGGGATCCCAGTGGACTGCTGAAGAACTTCCAGGACAT
CATGCAAAAGCAAAGACCAGAAAGAGTGTCTCATCTTCTTCAAGATAACTTGCCAAAATGAGAACTGCGACACATCACCAAGCTGAAGCC
CTGGAGCCTCTTTGATGTACTTGTGGAAAAGTATGGCTGGCCCCATGAAGATGCTGCACAGTTTACAGATTTCCTGATCCCGATGTTAGA
AATGGTTCCAGAAAAACGAGCCTCAGCTGGCGAATGCCTTCGGCATCCTTGGTTGAATTCTTAGCAAATTCTACCAATATTGCATTCTGA
GCTAGCAAATGTTCCCAGTACATTGGACCTAAACGGTGACTCTCATTCTTTAACAGGATTACAAGTGAGCTGGCTTCATCCTCAGACCTT
TATTTTGCTTTGAGGTACTGTTGTTTGACATTTTGCTTTTTGTGCACTGTGATCCTGGGGAAGGGTAGTCTTTTGTCTTCAGCTAAGTAG
TTTACTGACCATTTTCTTCTGGAAACAATAACATGTCTCTAAGCATTGTTTCTTGTGTTGTGTGACATTCAAATGTCATTTTTTTGAATG
AAAAATACTTTCCCCTTTGTGTTTTGGCAGGTTTTGTAACTATTTATGAAGAAATATTTTAGCTGAGTACTATATAATTTACAATCTTAA
GAAATTATCAAGTTGGAACCAAGAAATAGCAAGGAAATGTACAATTTTATCTTCTGGCAAAGGGACATCATTCCTGTATTATAGTGTATG
TAAATGCACCCTGTAAATGTTACTTTCCATTAAATATGGGAGGGGGACTCAAATTTCAGAAAAGCTACCAAGTCTTGAGTGCTTTGTAGC
CTATGTTGCATGTAGCGGACTTTAACTGCTCCAAGGAGTTGTGCAAACTTTTCATTCCATAACAGTCTTTTCACATTGGATTTTAAACAA
AGTGGCTCTGGGTTATAAGATGTCATTCTCTATATGGCACTTTAAAGGAAGAAAAGATATGTTTCTCATTCTAAAATATGCATTATAATT
TAGCAGTCCCATTTGTGATTTTGCATATTTTTAAAAGTACTTTTAAAGAAGAGCAATTTCCCTTTAAAAATGTGATGGCTCAGTACCATG
TCATGTTGCCTCCTCTGGGCGCTGTAAGTTAAGCTCTACATAGATTAAATTGGAGAAACGTGTTAATTGTGTGGAATGAAAAAATACATA
TATTTTTGGAAAAGCATGATCATGCTTGTCTAGAACACAAGGTATGGTATATACAATTTGCAGTGCAGTGGGCAGAATACTTCTCACAGC
TCAAAGATAACAGTGATCACATTCATTCCATAGGTAGCTTTACGTGTGGCTACAACAAATTTTACTAGCTTTTTCATTGTCTTTCCATGA
AACGAAGTTGAGAAAATGATTTTCCCTTTGCAGGTTGCACACAGTTTTGTTTATGCATTTCCTTAAAATTAATTGTAGACTCCAGGATAC
AAACCATAGTAGGCAATACAATTTTAGAATGTAATATATAGAGGTATATTTAGCCTCTTTTAGAAGTCAGTGGATTGAATGTCTTTTTAT
TTTAAATTTTACATTCATTAAGGTGCCTCGTTTTTGACTTTGTCCATTAACATTTATCCATATGCCTTTGCAATAACTAGATTGTGAAAA

>3723_3723_3_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000469224_SRPK2_chr7_104758469_ENST00000357311_length(amino acids)=194AA_BP=
MNMESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKETPPASEKDKTAKAKVQQTPDGSQQSPDG
TQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQR

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>3723_3723_4_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000484952_SRPK2_chr7_104758469_ENST00000357311_length(transcript)=2544nt_BP=898nt
CGGCGATCGCGGCCTGAGGCTGCTCCCGGACAAGGGCAACGAGCGTTTCGTTTGGACTTCTCGACTTGAGTGCCCGCCTCCTTCGCCGCC
GCCTCTGCAGTCCTCAGCGCAGTTATGCCCAGTTCTTCCCGCTGTGGGGACACGACCACGGAGGAATCCTTGCTTCAGGGACTCGGGACC
CTGCTGGACCCCTTCCTCGGGTTTAGGGGATGTGGGGACCAGGAGAAAGTCAGGATCCCTAAGAGTCTTCCCTGCCTGGATGGATGAGTG
GCTTCTTCTCCACCTAGATTCTTTCCACAGGAGCCAGCATACTTCCTGAACATGGAGAGTGTTGTTCGCCGCTGCCCATTCTTATCCCGA
GTCCCCCAGGCCTTTCTGCAGAAAGCAGGCAAATCTCTGTTGTTCTATGCCCAAAACTGCCCCAAGATGATGGAAGTTGGGGCCAAGCCA
GCCCCTCGGGCATTGTCCACTGCAGCAGTACACTACCAACAGATCAAAGAAACCCCTCCGGCCAGTGAGAAAGACAAAACTGCTAAGGCC
AAGGTCCAACAGACTCCTGATGGATCCCAGCAGAGTCCAGATGGCACACAGCTTCCGTCTGGACACCCCTTGCCTGCCACAAGCCAGGGC
ACTGCAAGCAAATGCCCTTTCCTGGCAGCACAGATGAATCAGAGAGGCAGCAGTGTCTTCTGCAAAGCCAGTCTTGAGCTTCAGGAGGAT
GTGCAGGAAATGAATGCCGTGAGGAAAGAGGTTGCTGAAACCTCAGCAGGCCCCAGTGTGGTTAGTGTGAAAACCGATGGAGGGGATCCC
AGTGGACTGCTGAAGAACTTCCAGGACATCATGCAAAAGCAAAGACCAGAAAGAGTGTCTCATCTTCTTCAAGATAACTTGCCAAAATGA
GAACTGCGACACATCACCAAGCTGAAGCCCTGGAGCCTCTTTGATGTACTTGTGGAAAAGTATGGCTGGCCCCATGAAGATGCTGCACAG
TTTACAGATTTCCTGATCCCGATGTTAGAAATGGTTCCAGAAAAACGAGCCTCAGCTGGCGAATGCCTTCGGCATCCTTGGTTGAATTCT
TAGCAAATTCTACCAATATTGCATTCTGAGCTAGCAAATGTTCCCAGTACATTGGACCTAAACGGTGACTCTCATTCTTTAACAGGATTA
CAAGTGAGCTGGCTTCATCCTCAGACCTTTATTTTGCTTTGAGGTACTGTTGTTTGACATTTTGCTTTTTGTGCACTGTGATCCTGGGGA
AGGGTAGTCTTTTGTCTTCAGCTAAGTAGTTTACTGACCATTTTCTTCTGGAAACAATAACATGTCTCTAAGCATTGTTTCTTGTGTTGT
GTGACATTCAAATGTCATTTTTTTGAATGAAAAATACTTTCCCCTTTGTGTTTTGGCAGGTTTTGTAACTATTTATGAAGAAATATTTTA
GCTGAGTACTATATAATTTACAATCTTAAGAAATTATCAAGTTGGAACCAAGAAATAGCAAGGAAATGTACAATTTTATCTTCTGGCAAA
GGGACATCATTCCTGTATTATAGTGTATGTAAATGCACCCTGTAAATGTTACTTTCCATTAAATATGGGAGGGGGACTCAAATTTCAGAA
AAGCTACCAAGTCTTGAGTGCTTTGTAGCCTATGTTGCATGTAGCGGACTTTAACTGCTCCAAGGAGTTGTGCAAACTTTTCATTCCATA
ACAGTCTTTTCACATTGGATTTTAAACAAAGTGGCTCTGGGTTATAAGATGTCATTCTCTATATGGCACTTTAAAGGAAGAAAAGATATG
TTTCTCATTCTAAAATATGCATTATAATTTAGCAGTCCCATTTGTGATTTTGCATATTTTTAAAAGTACTTTTAAAGAAGAGCAATTTCC
CTTTAAAAATGTGATGGCTCAGTACCATGTCATGTTGCCTCCTCTGGGCGCTGTAAGTTAAGCTCTACATAGATTAAATTGGAGAAACGT
GTTAATTGTGTGGAATGAAAAAATACATATATTTTTGGAAAAGCATGATCATGCTTGTCTAGAACACAAGGTATGGTATATACAATTTGC
AGTGCAGTGGGCAGAATACTTCTCACAGCTCAAAGATAACAGTGATCACATTCATTCCATAGGTAGCTTTACGTGTGGCTACAACAAATT
TTACTAGCTTTTTCATTGTCTTTCCATGAAACGAAGTTGAGAAAATGATTTTCCCTTTGCAGGTTGCACACAGTTTTGTTTATGCATTTC
CTTAAAATTAATTGTAGACTCCAGGATACAAACCATAGTAGGCAATACAATTTTAGAATGTAATATATAGAGGTATATTTAGCCTCTTTT
AGAAGTCAGTGGATTGAATGTCTTTTTATTTTAAATTTTACATTCATTAAGGTGCCTCGTTTTTGACTTTGTCCATTAACATTTATCCAT
ATGCCTTTGCAATAACTAGATTGTGAAAAGCTAACAAGTGTTGTAACAATAATCCATTGTTTGAGGTGCTTGCAGTTGTCTTAAAAATTA

>3723_3723_4_ALAS1-SRPK2_ALAS1_chr3_52238028_ENST00000484952_SRPK2_chr7_104758469_ENST00000357311_length(amino acids)=194AA_BP=
MNMESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKETPPASEKDKTAKAKVQQTPDGSQQSPDG
TQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQR

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Fusion Gene PPI Analysis for ALAS1-SRPK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALAS1-SRPK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ALAS1-SRPK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALAS1C0032708Disorders of Porphyrin Metabolism1CTD_human
TgeneC0005586Bipolar Disorder1CTD_human
TgeneC0005587Depression, Bipolar1CTD_human
TgeneC0024713Manic Disorder1CTD_human
TgeneC0338831Manic1CTD_human