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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ETV6-INO80D (FusionGDB2 ID:HG2120TG54891) |
Fusion Gene Summary for ETV6-INO80D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ETV6-INO80D | Fusion gene ID: hg2120tg54891 | Hgene | Tgene | Gene symbol | ETV6 | INO80D | Gene ID | 2120 | 54891 |
| Gene name | ETS variant transcription factor 6 | INO80 complex subunit D | |
| Synonyms | TEL|TEL/ABL|THC5 | - | |
| Cytomap | ('ETV6')('INO80D') 12p13.2 | 2q33.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor ETV6ETS translocation variant 6ETS variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene) | INO80 complex subunit D | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P41212 | Q53TQ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000396373, ENST00000544715, | ||
| Fusion gene scores | * DoF score | 59 X 37 X 25=54575 | 5 X 6 X 4=120 |
| # samples | 58 | 5 | |
| ** MAII score | log2(58/54575*10)=-6.55604351475058 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ETV6 [Title/Abstract] AND INO80D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ETV6(12022904)-INO80D(206868945), # samples:1 ETV6(12022904)-INO80D(206870260), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ETV6-INO80D seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ETV6-INO80D seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ETV6-INO80D seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ETV6-INO80D seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ETV6 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10514502 |
| Fusion gene breakpoints across ETV6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across INO80D (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | acute lymphoblastic leukemia;lymphoblastic lymphoma | JF736506 | ETV6 | chr12 | 12022904 | INO80D | chr2 | 206868945 |
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Fusion Gene ORF analysis for ETV6-INO80D |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000396373 | ENST00000403263 | ETV6 | chr12 | 12022904 | INO80D | chr2 | 206868945 | ||
| intron-3UTR | ENST00000544715 | ENST00000403263 | ETV6 | chr12 | 12022904 | INO80D | chr2 | 206868945 |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000396373 | ENST00000403263 | ETV6 | chr12 | 12022904 | + | INO80D | chr2 | 206870260 | - | 0.001634715 | 0.99836534 |
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Fusion Genomic Features for ETV6-INO80D |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ETV6-INO80D |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:12022904/chr2:206868945) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ETV6 | INO80D |
| FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. | FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ETV6 | chr12:12022904 | chr2:206870260 | ENST00000396373 | + | 5 | 8 | 40_124 | 336 | 453.0 | Domain | PNT |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ETV6 | chr12:12022904 | chr2:206870260 | ENST00000396373 | + | 5 | 8 | 339_420 | 336 | 453.0 | DNA binding | ETS |
| Tgene | INO80D | chr12:12022904 | chr2:206870260 | ENST00000403263 | 9 | 11 | 360_363 | 639 | 1028.0 | Compositional bias | Note=Poly-Asp |
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Fusion Gene Sequence for ETV6-INO80D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >27720_27720_1_ETV6-INO80D_ETV6_chr12_12022904_ENST00000396373_INO80D_chr2_206870260_ENST00000403263_length(transcript)=13096nt_BP=1283nt GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAAT TTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAAT GAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCA TATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCA TCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTT GCACCGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGAT CCGCCGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCC CATGGAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGAT GCCCAGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAG GGAAGGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGC CATGCCCATTGGGAGAATAGCAGGGAAGAATGGAGACCTCCTCCCAACTACCGAAGAGGCTGAGGAGCTTGAACGGGCCTTGCAGGCTGT AACTTCTCTCGAGTGCCTGAGTACCATTGGGGTCCTTGCCCAGTCAGATGGTGTGCCAGTCCAGGAGTTGTCAGATAGAGGAATAGGGGT GTTCTCCACAGGTACTGGAGCTTCAGGAATACAATCCTTGAGCCGAGAGGTGAACACAGACCTAGGGGAGCTATTGAATGGGCGTATAGT ACATGATAATTTTTCTAGTCTAGAGCTGGATGAGAACCTGCTCCGTTCTGCTACCTTGTCAAACCCACCTACACCCCTGGCAGGGCAGAT CCAGGGGCAGTTCTCTGCCCCAGCCAACGTTGGCCTTACTTCTGCCACTCTGATCAGCCAGAGTGCACTTGGGGAGAGAGCCTTCCCAGG ACAGTTTCATGGACTTCATGACGGCAGCCATGCCTCCCAGAGGCCACATCCTGCCCAGCTGCTGAGCAAGGCAGATGACCTAATCACCTC ACGACAGCAATACAGCAGTGATCACTCACACTCCTCACCCCATGGAAGCCATTATGATAGTGAGCATGTGCCGTCTCCCTACAGTGACCA TATCACCTCTCCCCACACAACATCGTACTCTGGTGATAATATGGCAGCTACCTTTTCAGCAGAGATGCCCATCATGGCGCAGCACTTGCT CCCAACCCAACTTGAGGTGCCACTTGGAGGCGTGGTAAACCCCAGAACTCACTGGGGCAATCTCCCTGTCAACCTTGGAGACCCCTCTCC ATTTAGCAACCTTCTCGGCGCAGATGGACATCTTCTTTCCACTTCCCTATCCACGCCACCCACCACTTCGAACTCAGAGACCACACAGCC TGCCTTCGCCACCGTGACCCCCAGCAGCTCCAGTGTGCTTCCGGGGTTACCACAGACCAGCTTCAGTGGCATGGGGCCTTCTGCTGAACT AATGGCCTCCACCTCTCCCAAGCAGCAACTCCCTCAGTTCAGCGCAGCCTTTGGCCACCAGCTGAGTTCTCACAGTGGCATTCCTAAGGA CCTGCAGCCCAGCCACAGCTCTATAGCCCCTCCTACAGGCTTCACAGTAACAGGTGCCACAGCTACAAGTACCAATAATGCATCTTCTCC CTTTCCCTCCCCTAACTGAGGGTGTCTGTGTGTTTGCAGGCAGGTGGGGAACCCAGTGTTTTCTATCTTTGTTTCCTCTTTAGCACCCCT CTCCCCTTTTCCTAAAGAAGATATAACAGATGGGGATCAGAGGGGCACCCCCCTTCCCAGTTCAATGAGTGGCCCTGCAGTGGACCTCGC TACAGTGTTCACATGTGCTCCTTAGCACTGGTGCTCATTCCCTCCTGGCAGGCCCACTCCGCCCCAGTGGTTTCCTTAGTGGTTCAGCAC AGTGACTGGATAGGATTGATTTTTAGCAGCAAGTCCTAGAAGTGGAAGATACCTCAGAATACCAGTGCCCTTTACTATTTCCTAGTATTC AGATCAGTGCTTTCCATTCTGTTGCCAGGTTTTTACATAGGTGGTTCTAGATAGAATGATCTTATTAATTGAGTTCCTGTATAAGAGACA GCAAATGGTGTGTGGCAGGTCAAGATTCTGACCTAGCACCAACTGCTAAACACCACAGTGAGGCCAGGATTCCATTCGTAATTGTGATCA TGTTTAACTAAAAGAAAAAAATGTGTCTTTTGACTGCCTGTGAGTATGCGTGTGCCCACGCGTGTGTTTTTGTGCAGTGCAGGAAGCAGC TGTCCCATTAGTTTGATTTTTTTTTGTTCTCCCCTTCCCCCTACTTAATGAGTATAAAACTCTTACTTTTCTCCTGTCCTACATCTCACA GTCCTAATAAGGTTGGTCCTTCTTTTCCTCAAGTTTCCTGAATAGGGAGGGTGGTGGACTGGTCGTGTGAGTAGCACAACCTTTTTCTGC TAAAAGTTAGCCCAAGAAGAAACAGAACATAGAAAGCTTGGATTCCCGTCAGTGAGGTAGGGATGTCCTAAAAAGCTTGCCTGGGATGAC TGCAGGCTGCCGGGGTTCTGGGGCCTGATGGTCACTTTGTCTTTTCAGACATTTGTTTGTTTCTAAATCCCTCTCTCATGGAATACATTT GCAAGATGTAATTAAAGAAAATATTTTGATGTGAAAAAGCAGGATAGGTCAGATAGATTTGAAAAGATGGGATCTGTCAACTCCTTGATC CATCTTTTGCTTTTGAATTTTTCATGTTTACAGTAGTGATTCTTTGGTAAGATTTGTAAAATGTTAAGACACTTGTAGAATCAGTGTACC AGTTGTGAAGTGATGTGTAATATCTGAAGGATACACATTTTAAAGTTTCTTTCAAAGCAGAATATGGAAATTAGATATAAATTTTATTCG CCCTTTGGTCCTTTTAAAATAATTCAAGTACTTGGGTTTAAGTAAATTTGAAAATAGCTTTGGGAAATGTTTTTAAAATGCCAGGATTTT AGGGGTTAAAGATCATATGGGGTAGTTTAGGAAGTTTGTGACTATGAGATGAATTTGTGAGGTTTCTTGCCTACCTTTTTTCCCCCCCAG AGAAGGGTGGAACTAGATTTTAAAGGCATCTCTACTCTGCTTTTGCTGAGTAGTTTCACTGTCCCTTGAGATACCATTGGCTATTTATAC CTGAGTCTAGTCTAATTCACATATATATATATTTTAAAAGTTGAGAGAACATACCTATTGATGTGGTTCAATAATTCATTTGTCAGGGAA TATTTGATCTTAATTCCTTTCTAATAGGTAGTGATTGGATGTATTTTCCTACTTCCTGTATGTAATCTCTTTATGCCATGCTAGTTCTAA CCAGTCCCTTCTTTTGAAAGCTTTTCTTTCTCTGCTTTTTAAAGGAATGATGGTGATCAGCAGGCATTATGCAGATACCACGTGCCTGAG GTTATGGAGGGGAAATGTCACATGACTGTATGAAATCATTATATGCCCTATTTTGTATTTATTGATGTTTCTTTTTGTGGGCCAAAAATA TGTTTGTAATATATTTAGTTTTTTTAAAATCATGGTAATTGATTGGAAGATTTATTTTTAATAGCTTTGCCTTTTTTGCAGAGTGCAAAA TTTCTAAATTATAACTTATGTCATAAAGCAAAATTATATTTGGTATCACCATAAATTTCTATTCTGAATGGTGAGAACAGATAATTTGAA TATTTCTCACCTGTGAGTCTATATTAGTAAGCTTTTTTATTTTAATGTACTGTAATGAAGTGGTCACGAGTAGTTACCTCGGCTCAAAAA TGTCATTTAGTTTGTTAAACTATTTTCACAACCATCATAAGCATAACTAGATAACTGTCCATTCCCAGCAGTTCAGTTTAGTCTCCATTG TGTATTTAAAGGTTGTCGCAGAGCAGCACATTGACTTCCTCATCAGCCCTTTGACAAGGAAGGGAAAGTCGTGGGTAGTCGATTTGAACT TTTTCTGTCTACTTGTCCCCTCATGTTAGCTGCTTGAAATTCTTCAGTTATGATACAAAGCTGAGTTTGCAGTAAGTTGCACATTTTATT GTTTGCAATTTTCTGTTTTATGTGCATTTAAAAGCCCTTCTCTGCTTTCTAGTAAGGAGGCATGAAATTATCAGGAATGTTGCTAGTTAC AGCTTCACACCAAAAACTTTGAGTAAATACATTTTCGTTTGGATGCCCATGATGAAAGCTGAGGAAAGTGGTTGAGGAATTATCAACAAC AAACTTTTCCTCTTATTTTATCTAGTTCAAAACAGATATCAAAGTTTGCAATTTGCTTTGCTCTTGCTGTTTCTTATGAGTCCCTTTTTG GAAGAGAGGAGAACATCTATAAGCCCAGAGAGATCTGTGTTTTTCTTTTACTTAATAGAGCCATTCTCGTCTATTAGTAGGAACTTTGCT ATTAATATGTATAGAAAGGAATGAAGTGGCTTTTACTCCAGAAATATGAAAATTAGTATCTTTTAAAATAGCACTTATGCTATCACAAGG CAATACTGGAATGAAAAACAAATCTTATATAAGGTCCTAAATAGGTAGAAACTAGCTTTTATTCTAGTGTTGAACCCAGGAGAAATAGTG GCAAAGAAGTTTCACTCTGTTTCTGCAGTTCTTTGGGACTATTTATAAAGGCCAGTTAGATTGTGTTACTGTGATTTAATTTACAAAGTT GCTGCAGTTAATGGATACATTCTGTGCTCTGAGAATCTGAATTCCATTCTAATGTGTGATATTCACTGGCTATGATCAGTAGTATCTGAA GAAAAGATGGGCTTTTTCTCCTTTACTCTCTCTACATAATTATTAATATTATTTTAATTAAAGTACTTAAGACATTGTTTTTTCTTCTGT AAAAATGGCTTAGCAATTTGCACATCTGGGTAGGTTATGTAGCTAGTAAACAACTCAATAGTAAGTAGCAATTATACTTAACCCACCAAG TGACAGACTATGCAATGGAAAAATTTTCTAATTATCGTCACATAGCTTAGACAGCAAAGGATTATTTTCTCTGGTGACCTACCATGTGTG ATATAACTGCTTTATAAATGACTTCCTGAGCAATTTCATGTTGGCAGGCAGTGTGGTGTGTCTAGTGCCCCTCTATGAGAAGACTATAAT TTAATCAGAAACAAATAGTAGGCATGGGGAGCAAGTTGGAAAGTGAGGTTATTATTTTTTTTCCTTAAAATTGGTGTTACTGTCTTTAGT GGCTTGAGGCTAAAGAAAGCTGATACTTTATCTTTGCCAAATAATTATTTATAAGATTTATTTTTAAATAAGCCCAATCTCTCACCTGCA GTTAAGAATCATCATTTTCTGTGACTGACACTAAAGCTCTTCCTTATCAGAGCTTGTTCTCAATCTGTGATCACAGTCCACAGTGGCAAA GACAACTCTTTGATTAGGAAGGAAACCATGTTTGGGATGCACAGAGGTGCCCTGTCCATACGGTTTTCTTCTTACATGAAAGAATTGACC TTTCTGTTGACCTATACCATTCTGTTTTTATAAAGTGGGATTAGAATTTGAGCATATCTAGTAAATGCCGTGTGGTCAGTCCGCTGATGC TTGCCCGCCGTCTTTGCCGTGCCTTGGCATCCTAGGGGTGCTGGTGATGGTCAGTGGGCATCATCGGTCAGCAGTGCACGTGTAAGGCAA TCTCCTCTCCTCCAGGTTAGTTCAGAAGGTCGCTATGGGTTGGTATTGCAAAAAGATGAGTATATGAACACTAAACTTATTAAGAGGTTT GAAATTCATTAAAAATTAGTTTTCAGTTTCTTCATCTTTCTTTTCAGACTTCTTTAAAAATACTGTTCTTAATCTGGTATATATAGAAAT CTAATATTATGGTCTTCTAAATGGTCAACAGAACTCTCCAGTTTAATGAGGCAATTTAGAGGATTCCTTGAAAGAAAATTTCATCATACT GAACAGTCCTCATTTGTATCTCTTTTGTTACCAGTATTTACATTGTTCCAAGGATTTTTTTCCTGACAAAAAATATATTTCTCGGGAGTG GAGAGTTTTTTATATATATATATGAAAGAACATAGATGTTTCCCCCCGCCCAATACATTAACTGAATCTTCACTGGCATTCTGTAGAAAA GTTAAAACAGTTTAATAATGTCTTAACATCTTTATACATTTTCCTATATTCTGGAGGAAACCAGAATCATGTTTAGTAGATTAAAGTAAC ATTTTAAATACTACCTTTCCAATAATTTGTAATAAAATACCAGTGAAGGACATGTTTGGATATCTGTTAAGCATTTTTCCCTGACTAATG AATTAGGAAAGAAAACATAAAACATAAATGAATAGTTATGTCTCTTCTAATAAACAGTGTCATTAATGCTGCAGTTGTGGGTCAAACTTA GGGAGCCTTATTTCTAAATAGCAAAAATTCTGTTTTCACTTCAGCCCTTATTTTTTTTTGTTAGTTTTTCTCTGCACTGTGATACAGAGC TAATAAGAGGAAATGTGACGTTTCAGAGAGAGAGCAAGCAAATTGGGTATGACTTTTTTACCCTATGTTCCCCAATACTGGGGATGTTTG GCTACTTTGAACAGCAGTTTTTAGTGATCTAAAGTTTAGATCAATACTCGTATAAGAGAAAAATCTAACTCTCAGTGAGCTCCATAGGGC AGCACAGCTTTCCATCTTCTCTTTCGCCTTCTTGCGTCTGCCCACCACAGTCCCGAAGAATGCACACGCACATATGATCTGTACCCATCC CGCCCGAAGAGTCATAGAATCCTCTTCTTTCACTTGTTTCTTTTTTCTTCGTTTGTTTGTTTTTGTTTGTTTGTTTTTTAAGCTGGGGAC CACTGAAGTAAGCTCTGTATGCACCCAAAGTTCCCCTTGGAAAAATTTTCAACACGCAGTGCAGAAGGCTCCAGTGCAGCTAAATGCCAC ACCATTGGTTCTACCTGGGGGAATAGACTGATTTGCCCTAAAATGACTCCAACCTGCATCATTAAGGTACAGTTGGCTCCAGTGGATTAG TGCTGAAATGATGGGAAGTCTGACACTTGTTGACATTGTCTTCATCTGTTTGGAAGGGTTGAATCTGTTCCTCTCAACAGTGATAGTTCT TTTCACTGTATAGTATTGAGTATGTCTCAGGGATTCCTTGTGGAAATTAGGGCAGTTTTTAAAATAAGAAAATAGTTTTAAAAGAAACTA AAGGTGACTCATCATTGAAGAGAGCGGAAGAAAGAGGAAACATTTGGTTTTGTAGCCCACAGTGTCTTGCATAGGACTTTTTCCTTTCTC CTCCAGGCTCTCATCTCAGCTTCAGAATACAGAATCCTTTCCCATCACGCACAGCTTTAAAACTTTTATTTAAAAATTTCCTTCCCCAAT GAGCTTTCAGAATACTTATTGTAGATTTTAAGAGAAAAGGTATATTAATTTATGCTATTAACATCACCTCATAAATTATAAGTTTTATAC TAAAGCTGTATCGAGTGTAATGAATTATGTTGCCTATGTGTTTAATAGCTAAATATATATGAGCTTTTTTTTTTTTTTTTTTTTTTGACA AAACAAACTAGTGAAGCACCTTTTTACACTGGATCTCTGCCGTGTCAAGGTGTATAGCTATCCTTTGCTACCTTGCAGATATATAAAATA AAAGGATATCCTGGGGCCTCAAAATGTAGAACACCTTTAGACCATTTATAACTGTTCCTAGAACTGTTGAGAATCATGTTCTTTAGTAAA TGATCTGTGGTTTACACTTAAGATGGCTAGAAGCTTAGTTACAGGGTACATAGAAATACATAGATCAAGTAAAACTCCAACTACTGTAGC TGGAATTTGTAAACTAAGTTTGTAAGACCTCTTTTATTTCCTATGGAGTTATTCTTTAATTTACAGTTTATTCTGTAAGTTGGGAAGTAA AATAGAGAAAATAATAAATCTAGATGTTCTCAGTGTCTTATTCAGGAACTTTTTATCCCTCCTCACTAAGGAATTCCCACTGTGACTTTA AAATAGAACTAAATTACTTGTGTGCATGTATATGTCTGTATTTTTTACACACATGCAAAAATATACATTGGGGGCACGTGTGTGAGAGAT ATGAATGTGTGCTTATATAAAAATAGATAAAGGTAACCGAATGTATTGTAGAAACATGATTTATTTAGTTGAGGGTATTGGAGTTACTTT CTCATTGTCTCTGTTGTATAAATACACCAAATTAATCATTATGTTATCTTATGTTAAAAGGCTAGCTCTGATATCATGTGCATTTTATGT TAACCTTTGGATTAACTTATATTATGCTATGTTCATAAAATGACATGAGAAACAGGAGGTTCTAAGATCAGCCTCTCACTTTCGAGCATA AAAATAAGAGAGGGAGACAGACAGCCCCAGACATGAGCTGTGTTTATCTATTGTGGTGATGGGACCACAGATCTATTGAATCTTTTTTAT GTTAATTATAGATTTCTTTATATTCGAGTAAGAAAATATTGTTGATCATCTTTTCTTGGTGAAGTTAAGAAAAAGTATAGGCCTTTCATA AACAATTTTTGGAAGGGGCTGCTTTGTTTAAGGAGTTGGTGGGATCATTTCACCGTGCATATTTCAAAGCTGGGGTGATTTCATTTATTT CCAAAATTTTTCAAAAAACTTTTACTCAGTTCTGCTGTTATTTATTAACTTAAGAGTGCTCCCATCCCCATATTTCAGCTATAGGAAAAT TGTGCTACCCCTGATTCATATGGAATTAAAAAAAAATACATCCCTTTATTTTGAGTTTTAAGTTGTTATTTTGCTATACATTTATTACTG GAGTATCTGGTGGTCTGAAATAGTCAAAAGTAGAGTTGGTATTAAATGTTCCAATGACATTTATTTTTAATACTTAAAAAATCATGTACT TTGAAATATGTCAAAGCAACTTCTGATAATATACCTGAATTTGTAGTTGTCTCTTGAGCATCATTTACTTCATCTTAGATATAGTGAAGA TCTAGGAAAGCTCTATATGCTGTTCTTTTCTACAGTTGTATTTTTGCAGCATCTCCTGGTTTCATTCACTCTTGTTTTGGGATTTTTTTT TAGATCTGCATATTTCTTGTACATATGCATGCAAATGAAAGAAGGGAGTTTGTACTGGTGCCATTTCTCCCTTCAGTTGCTGGTTAATGG GATTTGCTAGAAAAAATTCTCCCGGTTGAAGGGTGAAAACAGACCCTTATGTGTATATCTGTACAGAGATGTGTATATGGGATGTGGTGG CACTTTGCTGAATGTGAACTTGCCTTGTCAATGGAAAGATTGAAAAGTATTATGTTTATTTATACATTTGTATAAATCTATATATACACG TATGTATATGTGTGTGTATAGATAAAGCTATATACATATATTTCCCTTAAAAATGTGTGTGTATAATAGGTAAACAGCCTTTGTTAAGCA AGATTAATGTCTATGGAAAGTTCTGGATTATTCTGTAAGCCAGAGGAGGTGACAGTCTAGAGTACATCATCAGAACATACTAAAATGGAA GTCCTTTGGATTATAGTTTTGTTTATGGATATTACACAATGAATGCTTGTCTGAACAGTTCTTACTTGCCAGTTCCACTATTCTTCATCT TCACCACCTTCTACTGGTCAGTCTTTCATCACTTAAAAAAAAAAAAAAAATCACACATCATTGTGGTTTTTTTCCCCCTTAATTCTGTCT CTTCTAGCCAGAAGCATCTGGCTTAAGCATATTTCATCAACTTCTCTGTTATTTCTTTTAAAGATCTTTATCTCTGAAATTTTCCCAGAA GATACAAGTTTTGGTAATATTATCAATAGGAATTTTGAGACTTGGGCATTCATCTTTGTCTCAAAAACAAACAGAAAGCCAACCTTCAAA TAAAACAAATTTGAAAGTTTTAGCTCAATAATTTGGGGACATTTTACTTAAATTACAAAAGAACATAATTATGATTTTATGATCGATATT AGTGTTAGGTTTATTTCCACACTTACTGTCATTAATTTGTCATTTACATATTTTTATTTGCTTTGTAGTTTAATCATAACTTCACCATTT ACATTTTAATGGAAAGCATACAAGGTCACATGTTAGCCTCTTGAATTCTGTAACTAACTCATTTTTCTCATGATGAAACTGCTTTGATGA ATTCCTGTGTGATGAATTCTGCTATATTTCCTTTTGACTTTTCTCAGTTTGTGACATTCTGTATTAACTTTGCTGCAGCTCTCTAGAAAA CTTGCATCCCTATATATTGTGCCTTTAAAGCTCTTATGCACACACAGACAAAAGTGTATATATACATGTCAGAGCATGTGTACATATGCT TTCGTATGTACTCACACAGTATGTCTCTAGTATATATTGTGGGAGTAGATATATAGATATTCAAAGGCAATGAAATATTGCTCTCCAGAT ATATATGTATATAAATAGTGTTGATATAACTGTATATACACATGTATATGTATGAGTTTTAAATGGCAATCTTTTACATTTAGCAAAATG CTGCCCCTACTGGAATATTGTCACTGCAGTGGCAGTTGTATGTAATGATTTAAAATACATTATCAAAAGTTATTTAAAGAACATTTAAAG TCTCATCTAAAGACATCCACACACTATTTATTTATCTTCCTTTTCCTTTTATTGTTGTGTTTTTCTTAACTGAAAGGGAGACTGTCATTT TAAAAATGCCATCTGTCCCATGAGAGTAAGAAAGAGCTGGAGATTCACTTGAGGAGCTTTGTGCATTTTTCCTCTCTCTGAAGTGGAGAT GTTCCACAGACCAGACTGTTTATTTCACTTATAAAGCAATCCTAATATTTCCGTTAGTGTATGTCAGCCACCATCTCCTAGATCAACTTA ATTCACCAATTTGCCTCCTCCTTTCATTAATAAATAATGATTATTGAGATCATTTTGCCTGGGGGAAGTTAACTACTCCCATGCTGCAGG GAAATATATCACCTAATTGTTATTTTGCCTTGTTCAAAATTCAAATTTGAAAGAAGGCAGCTCTCTCATGAAGCTGTCTTAAGCACATTT TAGTTAAGGGCCCTCCCAAACTCTTTTTTCTTTCTTTCTTTCTTTCTTTTTTTTTTTTTTTTGCGAGTTCCAAGTTGCATGTGCTTGAAA TAGATTTAATTCTTATTCCCCACAGTTTAGGTATTTTTCATTAGTACATCAATTTGACACACTGAATGCAAGACTATTAAGGAAGAACGA TTAAATATTATTTTATTTTGTGAAGAGTTGGCAGCAGATTACATCTCAAGAACTTGCAGAGAGAGGAAGGTAGATGGACAATCCTAAATT GTAAGATGTTACAAAAAACAGTGAAGTAAGAGTACTCCTGAAGACTAAAATAGAGAGGCTGGGGTTTGAGCCATTTTACTGAGTAGCTTA GCTGGAACCTGATATCAGAAGTAGCCTTTAACAAAAAGCCTCTTGGCAATTGTATGGTACTAACAACTAGAGTACTGAAGTGTAAGTTGA AACCAAGTTGCAGTGGGAAATCAAAGGTGAGGTAGCTTATTTGAAACCAGCAAATGAGACAGGTTGGACAGTTTTAAAATCTCTTCTAAC AAAGAAACTGCACGGTAGCAAGGACTAGCGGTTCTCAAAGCCCTTCTTTTTCAGTGTTCTCATTCACCTTGGCACCCAAGTATGTTTAAC AGGCCATGCATTAAAAATAAATACAAAAATATAAAAGCCGCTTAAAGGGAACTTACAAACTGACAATCTCTCCTCTGTATTTGTGTTCAT AGTGGCTGGGAGTTTAATTATATGCACAAAAGTTAGGAGCCACTTGTTTCTGCACAGACTGTAGGAGCAAGATGAGGAGATGGGCAGGTT TTGGTAAGAGCCCCCAGTTCTGGTGGACAGGCATACTTGTGGCATTGGGTGCGGCATTGCTGGGAGGACCACGTCTTGGGAGGCGATTGA CTTTTGGTTTGTAATTTCCCTTTAAACAAGAAGAGATGGCTCACATTTTCCATATATATCTCAATGAATGTACTGTATTACTGTTTTAAA AATTTGATGAAATAATAATGAATTGGTCTCCTTTTGTTATCTGGTCCTTGTTTAATTTGTTTAAGGGTTTTTGTATACAAAAGTTTACAT TTTTATGTATATTTTTCTTGTGTAAAAACTGATGTAATATGTGTATGAAACACTGTATGTATTATCTGTATATAGTGTGACAAAATCATT TTTCTTTCTTTCTTTTGGATGTATTAATAAATCTTGCTGTGAAGTA >27720_27720_1_ETV6-INO80D_ETV6_chr12_12022904_ENST00000396373_INO80D_chr2_206870260_ENST00000403263_length(amino acids)=724AA_BP=336 MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIAGKNGDLLPTTEEAEELERALQAVT SLECLSTIGVLAQSDGVPVQELSDRGIGVFSTGTGASGIQSLSREVNTDLGELLNGRIVHDNFSSLELDENLLRSATLSNPPTPLAGQIQ GQFSAPANVGLTSATLISQSALGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHI TSPHTTSYSGDNMAATFSAEMPIMAQHLLPTQLEVPLGGVVNPRTHWGNLPVNLGDPSPFSNLLGADGHLLSTSLSTPPTTSNSETTQPA FATVTPSSSSVLPGLPQTSFSGMGPSAELMASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTGATATSTNNASSPF PSPN -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ETV6-INO80D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ETV6-INO80D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ETV6-INO80D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ETV6 | C4015537 | THROMBOCYTOPENIA 5 | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | ETV6 | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 3 | CTD_human |
| Hgene | ETV6 | C0040034 | Thrombocytopenia | 3 | CTD_human;GENOMICS_ENGLAND |
| Hgene | ETV6 | C0023480 | Leukemia, Myelomonocytic, Chronic | 2 | ORPHANET |
| Hgene | ETV6 | C1332965 | Congenital Mesoblastic Nephroma | 2 | ORPHANET |
| Hgene | ETV6 | C0006413 | Burkitt Lymphoma | 1 | ORPHANET |
| Hgene | ETV6 | C0013146 | Drug abuse | 1 | CTD_human |
| Hgene | ETV6 | C0013170 | Drug habituation | 1 | CTD_human |
| Hgene | ETV6 | C0013222 | Drug Use Disorders | 1 | CTD_human |
| Hgene | ETV6 | C0023452 | Childhood Acute Lymphoblastic Leukemia | 1 | CTD_human |
| Hgene | ETV6 | C0023453 | L2 Acute Lymphoblastic Leukemia | 1 | CTD_human |
| Hgene | ETV6 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CGI;CTD_human;GENOMICS_ENGLAND |
| Hgene | ETV6 | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
| Hgene | ETV6 | C0038580 | Substance Dependence | 1 | CTD_human |
| Hgene | ETV6 | C0038586 | Substance Use Disorders | 1 | CTD_human |
| Hgene | ETV6 | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human |
| Hgene | ETV6 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Hgene | ETV6 | C0238463 | Papillary thyroid carcinoma | 1 | ORPHANET |
| Hgene | ETV6 | C0376544 | Hematopoietic Neoplasms | 1 | CTD_human |
| Hgene | ETV6 | C0376545 | Hematologic Neoplasms | 1 | CTD_human |
| Hgene | ETV6 | C0740858 | Substance abuse problem | 1 | CTD_human |
| Hgene | ETV6 | C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | ORPHANET |
| Hgene | ETV6 | C1510472 | Drug Dependence | 1 | CTD_human |
| Hgene | ETV6 | C1832388 | Platelet Disorder, Familial, with Associated Myeloid Malignancy | 1 | ORPHANET |
| Hgene | ETV6 | C1838656 | Macrocytosis, Familial | 1 | CTD_human |
| Hgene | ETV6 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
| Hgene | ETV6 | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Hgene | ETV6 | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human |
| Hgene | ETV6 | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
| Hgene | ETV6 | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human |
| Hgene | ETV6 | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human |
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