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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:MECOM-ANKRD10 (FusionGDB2 ID:HG2122TG55608)

Fusion Gene Summary for MECOM-ANKRD10

check button Fusion gene summary
Fusion gene informationFusion gene name: MECOM-ANKRD10
Fusion gene ID: hg2122tg55608
HgeneTgene
Gene symbol

MECOM

ANKRD10

Gene ID

2122

55608

Gene nameMDS1 and EVI1 complex locusankyrin repeat domain 10
SynonymsAML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2-
Cytomap('MECOM')('ANKRD10')

3q26.2

13q34

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase MECOMAML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein EVI1MDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein ankyrin repeat domain-containing protein 10
Modification date2020031320200313
UniProtAcc

Q03112

Q9NXR5

Ensembl transtripts involved in fusion geneENST00000264674, ENST00000392736, 
ENST00000433243, ENST00000460814, 
ENST00000464456, ENST00000468789, 
ENST00000472280, ENST00000494292, 
ENST00000485957, 
Fusion gene scores* DoF score33 X 21 X 11=76235 X 4 X 2=40
# samples 435
** MAII scorelog2(43/7623*10)=-4.14795031118505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MECOM [Title/Abstract] AND ANKRD10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMECOM(168849217)-ANKRD10(111536140), # samples:1
Anticipated loss of major functional domain due to fusion event.MECOM-ANKRD10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MECOM-ANKRD10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MECOM-ANKRD10 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MECOM-ANKRD10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MECOM-ANKRD10 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMECOM

GO:0045892

negative regulation of transcription, DNA-templated

10856240|11568182

HgeneMECOM

GO:0045893

positive regulation of transcription, DNA-templated

11568182|19767769

HgeneMECOM

GO:0051726

regulation of cell cycle

11568182


check buttonFusion gene breakpoints across MECOM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ANKRD10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-4191-01AMECOMchr3

168849217

-ANKRD10chr13

111536140

-


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Fusion Gene ORF analysis for MECOM-ANKRD10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000264674ENST00000375758MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-3UTRENST00000392736ENST00000375758MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-3UTRENST00000433243ENST00000375758MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-3UTRENST00000460814ENST00000375758MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-3UTRENST00000464456ENST00000375758MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-3UTRENST00000468789ENST00000375758MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-3UTRENST00000472280ENST00000375758MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-3UTRENST00000494292ENST00000375758MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-5UTRENST00000264674ENST00000489973MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-5UTRENST00000392736ENST00000489973MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-5UTRENST00000433243ENST00000489973MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-5UTRENST00000460814ENST00000489973MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-5UTRENST00000464456ENST00000489973MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-5UTRENST00000468789ENST00000489973MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-5UTRENST00000472280ENST00000489973MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-5UTRENST00000494292ENST00000489973MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-intronENST00000264674ENST00000310847MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-intronENST00000392736ENST00000310847MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-intronENST00000433243ENST00000310847MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-intronENST00000460814ENST00000310847MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-intronENST00000464456ENST00000310847MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-intronENST00000468789ENST00000310847MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-intronENST00000472280ENST00000310847MECOMchr3

168849217

-ANKRD10chr13

111536140

-
5CDS-intronENST00000494292ENST00000310847MECOMchr3

168849217

-ANKRD10chr13

111536140

-
Frame-shiftENST00000433243ENST00000267339MECOMchr3

168849217

-ANKRD10chr13

111536140

-
Frame-shiftENST00000460814ENST00000267339MECOMchr3

168849217

-ANKRD10chr13

111536140

-
Frame-shiftENST00000464456ENST00000267339MECOMchr3

168849217

-ANKRD10chr13

111536140

-
Frame-shiftENST00000468789ENST00000267339MECOMchr3

168849217

-ANKRD10chr13

111536140

-
In-frameENST00000264674ENST00000267339MECOMchr3

168849217

-ANKRD10chr13

111536140

-
In-frameENST00000392736ENST00000267339MECOMchr3

168849217

-ANKRD10chr13

111536140

-
In-frameENST00000472280ENST00000267339MECOMchr3

168849217

-ANKRD10chr13

111536140

-
In-frameENST00000494292ENST00000267339MECOMchr3

168849217

-ANKRD10chr13

111536140

-
intron-3CDSENST00000485957ENST00000267339MECOMchr3

168849217

-ANKRD10chr13

111536140

-
intron-3UTRENST00000485957ENST00000375758MECOMchr3

168849217

-ANKRD10chr13

111536140

-
intron-5UTRENST00000485957ENST00000489973MECOMchr3

168849217

-ANKRD10chr13

111536140

-
intron-intronENST00000485957ENST00000310847MECOMchr3

168849217

-ANKRD10chr13

111536140

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264674MECOMchr3168849217-ENST00000267339ANKRD10chr13111536140-2049380130951273
ENST00000392736MECOMchr3168849217-ENST00000267339ANKRD10chr13111536140-1987318260889209
ENST00000472280MECOMchr3168849217-ENST00000267339ANKRD10chr13111536140-1987318260889209
ENST00000494292MECOMchr3168849217-ENST00000267339ANKRD10chr13111536140-2380711981282394

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264674ENST00000267339MECOMchr3168849217-ANKRD10chr13111536140-0.0010273910.99897265
ENST00000392736ENST00000267339MECOMchr3168849217-ANKRD10chr13111536140-0.002790280.9972097
ENST00000472280ENST00000267339MECOMchr3168849217-ANKRD10chr13111536140-0.002790280.9972097
ENST00000494292ENST00000267339MECOMchr3168849217-ANKRD10chr13111536140-0.0023539170.99764603

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Fusion Genomic Features for MECOM-ANKRD10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for MECOM-ANKRD10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:168849217/chr13:111536140)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MECOM

Q03112

ANKRD10

Q9NXR5

FUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANKRD10chr3:168849217chr13:111536140ENST0000031084705124_1530221.0RepeatNote=ANK 4
TgeneANKRD10chr3:168849217chr13:111536140ENST000003108470521_500221.0RepeatNote=ANK 1
TgeneANKRD10chr3:168849217chr13:111536140ENST000003108470557_860221.0RepeatNote=ANK 2
TgeneANKRD10chr3:168849217chr13:111536140ENST000003108470591_1200221.0RepeatNote=ANK 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-4171065_1116801117.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-3161065_1116161052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-4171065_1116161053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-3151065_1116161043.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-3161065_1116161052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-3161065_1116161053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-41778_190801117.0DomainSET
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-31678_190161052.0DomainSET
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-41778_190161053.0DomainSET
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-31578_190161043.0DomainSET
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-31678_190161052.0DomainSET
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-31678_190161053.0DomainSET
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417609_622801117.0MotifNuclear localization signal
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417741_745801117.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417772_776801117.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316609_622161052.0MotifNuclear localization signal
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316741_745161052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316772_776161052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417609_622161053.0MotifNuclear localization signal
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417741_745161053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417772_776161053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315609_622161043.0MotifNuclear localization signal
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315741_745161043.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315772_776161043.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316609_622161052.0MotifNuclear localization signal
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316741_745161052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316772_776161052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316609_622161053.0MotifNuclear localization signal
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316741_745161053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316772_776161053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417209_236801117.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417263_285801117.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417291_313801117.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417319_342801117.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417348_370801117.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417376_398801117.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417405_427801117.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417912_934801117.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417940_963801117.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417969_991801117.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316209_236161052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316263_285161052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316291_313161052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316319_342161052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316348_370161052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316376_398161052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316405_427161052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316912_934161052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316940_963161052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316969_991161052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417209_236161053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417263_285161053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417291_313161053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417319_342161053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417348_370161053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417376_398161053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417405_427161053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417912_934161053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417940_963161053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417969_991161053.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315209_236161043.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315263_285161043.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315291_313161043.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315319_342161043.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315348_370161043.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315376_398161043.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315405_427161043.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315912_934161043.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315940_963161043.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315969_991161043.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316209_236161052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316263_285161052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316291_313161052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316319_342161052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316348_370161052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316376_398161052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316405_427161052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316912_934161052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316940_963161052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316969_991161052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316209_236161053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316263_285161053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316291_313161053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316319_342161053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316348_370161053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316376_398161053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316405_427161053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316912_934161053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316940_963161053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316969_991161053.0Zinc fingerC2H2-type 10
TgeneANKRD10chr3:168849217chr13:111536140ENST0000026733936124_153230421.0RepeatNote=ANK 4
TgeneANKRD10chr3:168849217chr13:111536140ENST000002673393621_50230421.0RepeatNote=ANK 1
TgeneANKRD10chr3:168849217chr13:111536140ENST000002673393657_86230421.0RepeatNote=ANK 2
TgeneANKRD10chr3:168849217chr13:111536140ENST000002673393691_120230421.0RepeatNote=ANK 3
TgeneANKRD10chr3:168849217chr13:111536140ENST0000037575847124_153261659.0RepeatNote=ANK 4
TgeneANKRD10chr3:168849217chr13:111536140ENST000003757584721_50261659.0RepeatNote=ANK 1
TgeneANKRD10chr3:168849217chr13:111536140ENST000003757584757_86261659.0RepeatNote=ANK 2
TgeneANKRD10chr3:168849217chr13:111536140ENST000003757584791_120261659.0RepeatNote=ANK 3


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Fusion Gene Sequence for MECOM-ANKRD10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52486_52486_1_MECOM-ANKRD10_MECOM_chr3_168849217_ENST00000264674_ANKRD10_chr13_111536140_ENST00000267339_length(transcript)=2049nt_BP=380nt
CCTTGCCAAGTAACAGCTTTGCTGTCCAACATCGTGTGCTGCTTCGCGAGAAAGTCACATTCGGACCCTTTGGCTAGATTGCTTATTCAT
AGGGCTTCTTGACTAAAGCCCTTGGAGCACTGGGTTTTTCTTGAAGTATATGATCTTAGACGAATTTTACAATGTGAAGTTCTGCATAGA
TGCCAGTCAACCAGATGTTGGAAGCTGGCTCAAGTACATTAGATTCGCTGGCTGTTATGATCAGCACAACCTTGTTGCATGCCAGATAAA
TGATCAGATATTCTATAGAGTAGTTGCAGACATTGCGCCGGGAGAGGAGCTTCTGCTGTTCATGAAGAGCGAAGACTATCCCCATGAAAC
TATGGCGCCGGATATCCACGCTCAAAGCTTGGATTCTGCCGTGCCACTCACGAATGGCGACACAGAAGACGATGCTGACAAAATGCACGT
TGATAGGGAGTTTGCTGTTGTAACAGATATGAAAAACAGTAGCTCCGTATCGAATACATTGACAAATGGATGTGTCATCAATGGACATTT
GGACTTCCCCTCCACGACCCCGCTCAGTGGGATGGAAAGCAGGAATGGCCAGTGCTTGACAGGAACTAACGGAATTAGCAGTGGATTAGC
CCCAGGACAGCCGTTTCCGAGTAGCCAGGGTTCTCTCTGCATTAGTGGGACTGAGGAGCCAGAGAAGACCCTGAGAGCTAACCCTGAGTT
GTGCGGTTCTCTGCACCTGAACGGGAGTCCAAGTAGCTGCATAGCCAGTAGGCCTTCCTGGGTGGAAGACATTGGGGATAACCTGTACTA
TGGACACTACCACGGGTTTGGGGACACTGCTGAAAGCATCCCAGAACTGAACAGTGTGGTCGAGCATTCCAAGTCCGTGAAGGTGCAGGA
GCGGTACGACAGTGCCGTGCTGGGCACCATGCACCTGCACCACGGCTCCTAGAGACGCTGACCTGGCTCTCGGAAACGCAGGAGTCCTTC
CTGGTAGCCAGCTCAGAATACCCATGTAGCAGCAACTTGAACGAATGTCACAACTTGTACGTTTTTTATATACTTCAACTTTCTGAAAAA
GTAAACTTCGACAAGTTCCCAGCAACTGCTTGTTTGTGCATGAGTAGGGCTTACTAAGTGCATAGATGTTTCTACAGTGAGGTGTCCTTT
TTATAAGGTGCACTTTTGGAGTTTTTCTGATGCCAATCTCAACATTGTCTTTTTAATACTGTCACCAGATATTGCCATTTTTCTTTTTGT
TAAAAGATTATATGATCAAGATAAATTGGGGTGGTAAATCAGGTGCCTGGTAATTTATCTCTTTGCACATGGGCATCATTTTAAAAAGCT
TGCTTCCACTCTTTTCTGTAGAATTTGACGGAACACAGCTATTTCCCTATGCAAGGTACAGCCTTACAAAGATTTCTGCAGTGATTTGTG
TGAAGAAGAGAACGTTTGTCTTTTTCAATGAAGCTTTGCAGATCACCATGTGGTTGAAGGTTTTAGTTGTGGACACAGTGGTCCCTCCTT
AATGATGAAGATCACTGCCTTGGGCTTCATGGAAAACAGGCCCAGCCTGGGGCTGCGTTTGGATTTATTGTTTTTATTCCACACTTCCTA
CTTGGTCTCTGGAAGTTTTACCACATGTAACAGATTCCTTTATATGTAGTGGAAATCACTATTTGTAGAAACTGTCAGGTCAAAATATTT
AACTGACTGTTGACATGTATTTTCTTTTTTCCTTGTTTTTGTTTTTTGGGGTTTTCTGCTTTAAGATATATACCACTATGTATATCCAGT
TAACTGAGAGAATTTTGACTCTCTTAATAAAACTGCATTAAGTTTTTGATTTTGTAGAAATTAGCTTTTGTCTAGGCAACTAGTGGTTAT
ACTCTGCAAATATTGTAATGAATTTTTACTTTTTTGATTTTTGTAATAAAAATTGGTGCAGATAAAATGTCAAATGAACAAACCAGTGTT

>52486_52486_1_MECOM-ANKRD10_MECOM_chr3_168849217_ENST00000264674_ANKRD10_chr13_111536140_ENST00000267339_length(amino acids)=273AA_BP=83
MKYMILDEFYNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHAQSLDSA
VPLTNGDTEDDADKMHVDREFAVVTDMKNSSSVSNTLTNGCVINGHLDFPSTTPLSGMESRNGQCLTGTNGISSGLAPGQPFPSSQGSLC
ISGTEEPEKTLRANPELCGSLHLNGSPSSCIASRPSWVEDIGDNLYYGHYHGFGDTAESIPELNSVVEHSKSVKVQERYDSAVLGTMHLH

--------------------------------------------------------------
>52486_52486_2_MECOM-ANKRD10_MECOM_chr3_168849217_ENST00000392736_ANKRD10_chr13_111536140_ENST00000267339_length(transcript)=1987nt_BP=318nt
CCTTGCCAAGTAACAGCTTTGCTGTCCAACATCGTGTGCTGCTTCGCGAGAAAGTCACATTCGGACCCTTTGGCTAGATTATCTTAGACG
AATTTTACAATGTGAAGTTCTGCATAGATGCCAGTCAACCAGATGTTGGAAGCTGGCTCAAGTACATTAGATTCGCTGGCTGTTATGATC
AGCACAACCTTGTTGCATGCCAGATAAATGATCAGATATTCTATAGAGTAGTTGCAGACATTGCGCCGGGAGAGGAGCTTCTGCTGTTCA
TGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCCACGCTCAAAGCTTGGATTCTGCCGTGCCACTCACGAATGGCGACA
CAGAAGACGATGCTGACAAAATGCACGTTGATAGGGAGTTTGCTGTTGTAACAGATATGAAAAACAGTAGCTCCGTATCGAATACATTGA
CAAATGGATGTGTCATCAATGGACATTTGGACTTCCCCTCCACGACCCCGCTCAGTGGGATGGAAAGCAGGAATGGCCAGTGCTTGACAG
GAACTAACGGAATTAGCAGTGGATTAGCCCCAGGACAGCCGTTTCCGAGTAGCCAGGGTTCTCTCTGCATTAGTGGGACTGAGGAGCCAG
AGAAGACCCTGAGAGCTAACCCTGAGTTGTGCGGTTCTCTGCACCTGAACGGGAGTCCAAGTAGCTGCATAGCCAGTAGGCCTTCCTGGG
TGGAAGACATTGGGGATAACCTGTACTATGGACACTACCACGGGTTTGGGGACACTGCTGAAAGCATCCCAGAACTGAACAGTGTGGTCG
AGCATTCCAAGTCCGTGAAGGTGCAGGAGCGGTACGACAGTGCCGTGCTGGGCACCATGCACCTGCACCACGGCTCCTAGAGACGCTGAC
CTGGCTCTCGGAAACGCAGGAGTCCTTCCTGGTAGCCAGCTCAGAATACCCATGTAGCAGCAACTTGAACGAATGTCACAACTTGTACGT
TTTTTATATACTTCAACTTTCTGAAAAAGTAAACTTCGACAAGTTCCCAGCAACTGCTTGTTTGTGCATGAGTAGGGCTTACTAAGTGCA
TAGATGTTTCTACAGTGAGGTGTCCTTTTTATAAGGTGCACTTTTGGAGTTTTTCTGATGCCAATCTCAACATTGTCTTTTTAATACTGT
CACCAGATATTGCCATTTTTCTTTTTGTTAAAAGATTATATGATCAAGATAAATTGGGGTGGTAAATCAGGTGCCTGGTAATTTATCTCT
TTGCACATGGGCATCATTTTAAAAAGCTTGCTTCCACTCTTTTCTGTAGAATTTGACGGAACACAGCTATTTCCCTATGCAAGGTACAGC
CTTACAAAGATTTCTGCAGTGATTTGTGTGAAGAAGAGAACGTTTGTCTTTTTCAATGAAGCTTTGCAGATCACCATGTGGTTGAAGGTT
TTAGTTGTGGACACAGTGGTCCCTCCTTAATGATGAAGATCACTGCCTTGGGCTTCATGGAAAACAGGCCCAGCCTGGGGCTGCGTTTGG
ATTTATTGTTTTTATTCCACACTTCCTACTTGGTCTCTGGAAGTTTTACCACATGTAACAGATTCCTTTATATGTAGTGGAAATCACTAT
TTGTAGAAACTGTCAGGTCAAAATATTTAACTGACTGTTGACATGTATTTTCTTTTTTCCTTGTTTTTGTTTTTTGGGGTTTTCTGCTTT
AAGATATATACCACTATGTATATCCAGTTAACTGAGAGAATTTTGACTCTCTTAATAAAACTGCATTAAGTTTTTGATTTTGTAGAAATT
AGCTTTTGTCTAGGCAACTAGTGGTTATACTCTGCAAATATTGTAATGAATTTTTACTTTTTTGATTTTTGTAATAAAAATTGGTGCAGA
TAAAATGTCAAATGAACAAACCAGTGTTCTAAGAGTGTTACTAACATTTTGTTCTAAAACTGTCCTTCACAAATTGAATAAAAAACTCTC

>52486_52486_2_MECOM-ANKRD10_MECOM_chr3_168849217_ENST00000392736_ANKRD10_chr13_111536140_ENST00000267339_length(amino acids)=209AA_BP=19
MLFMKSEDYPHETMAPDIHAQSLDSAVPLTNGDTEDDADKMHVDREFAVVTDMKNSSSVSNTLTNGCVINGHLDFPSTTPLSGMESRNGQ
CLTGTNGISSGLAPGQPFPSSQGSLCISGTEEPEKTLRANPELCGSLHLNGSPSSCIASRPSWVEDIGDNLYYGHYHGFGDTAESIPELN

--------------------------------------------------------------
>52486_52486_3_MECOM-ANKRD10_MECOM_chr3_168849217_ENST00000472280_ANKRD10_chr13_111536140_ENST00000267339_length(transcript)=1987nt_BP=318nt
CCTTGCCAAGTAACAGCTTTGCTGTCCAACATCGTGTGCTGCTTCGCGAGAAAGTCACATTCGGACCCTTTGGCTAGATTATCTTAGACG
AATTTTACAATGTGAAGTTCTGCATAGATGCCAGTCAACCAGATGTTGGAAGCTGGCTCAAGTACATTAGATTCGCTGGCTGTTATGATC
AGCACAACCTTGTTGCATGCCAGATAAATGATCAGATATTCTATAGAGTAGTTGCAGACATTGCGCCGGGAGAGGAGCTTCTGCTGTTCA
TGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCCACGCTCAAAGCTTGGATTCTGCCGTGCCACTCACGAATGGCGACA
CAGAAGACGATGCTGACAAAATGCACGTTGATAGGGAGTTTGCTGTTGTAACAGATATGAAAAACAGTAGCTCCGTATCGAATACATTGA
CAAATGGATGTGTCATCAATGGACATTTGGACTTCCCCTCCACGACCCCGCTCAGTGGGATGGAAAGCAGGAATGGCCAGTGCTTGACAG
GAACTAACGGAATTAGCAGTGGATTAGCCCCAGGACAGCCGTTTCCGAGTAGCCAGGGTTCTCTCTGCATTAGTGGGACTGAGGAGCCAG
AGAAGACCCTGAGAGCTAACCCTGAGTTGTGCGGTTCTCTGCACCTGAACGGGAGTCCAAGTAGCTGCATAGCCAGTAGGCCTTCCTGGG
TGGAAGACATTGGGGATAACCTGTACTATGGACACTACCACGGGTTTGGGGACACTGCTGAAAGCATCCCAGAACTGAACAGTGTGGTCG
AGCATTCCAAGTCCGTGAAGGTGCAGGAGCGGTACGACAGTGCCGTGCTGGGCACCATGCACCTGCACCACGGCTCCTAGAGACGCTGAC
CTGGCTCTCGGAAACGCAGGAGTCCTTCCTGGTAGCCAGCTCAGAATACCCATGTAGCAGCAACTTGAACGAATGTCACAACTTGTACGT
TTTTTATATACTTCAACTTTCTGAAAAAGTAAACTTCGACAAGTTCCCAGCAACTGCTTGTTTGTGCATGAGTAGGGCTTACTAAGTGCA
TAGATGTTTCTACAGTGAGGTGTCCTTTTTATAAGGTGCACTTTTGGAGTTTTTCTGATGCCAATCTCAACATTGTCTTTTTAATACTGT
CACCAGATATTGCCATTTTTCTTTTTGTTAAAAGATTATATGATCAAGATAAATTGGGGTGGTAAATCAGGTGCCTGGTAATTTATCTCT
TTGCACATGGGCATCATTTTAAAAAGCTTGCTTCCACTCTTTTCTGTAGAATTTGACGGAACACAGCTATTTCCCTATGCAAGGTACAGC
CTTACAAAGATTTCTGCAGTGATTTGTGTGAAGAAGAGAACGTTTGTCTTTTTCAATGAAGCTTTGCAGATCACCATGTGGTTGAAGGTT
TTAGTTGTGGACACAGTGGTCCCTCCTTAATGATGAAGATCACTGCCTTGGGCTTCATGGAAAACAGGCCCAGCCTGGGGCTGCGTTTGG
ATTTATTGTTTTTATTCCACACTTCCTACTTGGTCTCTGGAAGTTTTACCACATGTAACAGATTCCTTTATATGTAGTGGAAATCACTAT
TTGTAGAAACTGTCAGGTCAAAATATTTAACTGACTGTTGACATGTATTTTCTTTTTTCCTTGTTTTTGTTTTTTGGGGTTTTCTGCTTT
AAGATATATACCACTATGTATATCCAGTTAACTGAGAGAATTTTGACTCTCTTAATAAAACTGCATTAAGTTTTTGATTTTGTAGAAATT
AGCTTTTGTCTAGGCAACTAGTGGTTATACTCTGCAAATATTGTAATGAATTTTTACTTTTTTGATTTTTGTAATAAAAATTGGTGCAGA
TAAAATGTCAAATGAACAAACCAGTGTTCTAAGAGTGTTACTAACATTTTGTTCTAAAACTGTCCTTCACAAATTGAATAAAAAACTCTC

>52486_52486_3_MECOM-ANKRD10_MECOM_chr3_168849217_ENST00000472280_ANKRD10_chr13_111536140_ENST00000267339_length(amino acids)=209AA_BP=19
MLFMKSEDYPHETMAPDIHAQSLDSAVPLTNGDTEDDADKMHVDREFAVVTDMKNSSSVSNTLTNGCVINGHLDFPSTTPLSGMESRNGQ
CLTGTNGISSGLAPGQPFPSSQGSLCISGTEEPEKTLRANPELCGSLHLNGSPSSCIASRPSWVEDIGDNLYYGHYHGFGDTAESIPELN

--------------------------------------------------------------
>52486_52486_4_MECOM-ANKRD10_MECOM_chr3_168849217_ENST00000494292_ANKRD10_chr13_111536140_ENST00000267339_length(transcript)=2380nt_BP=711nt
AGAGAGAGGGAGGGAGCGAGAGGGAGAGCAAAAGAAGGAAAGGATCCAAGAAAAAAAAGCCCCAACCACACACCAGCGGCTGCAGGACTG
GGCACAGCATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAATAATGAGTGTGTATATGGCAACTACCCTGAAATACCTTTGGAAG
AAATGCCAGATGCAGATGGAGTAGCCAGCACTCCCTCCCTCAATATTCAAGAGCCATGCTCTCCTGCCACATCCAGTGAAGCATTCACTC
CAAAGGAGGGTTCTCCTTACAAAGCCCCCATCTACATCCCTGATGATATCCCCATTCCTGCTGAGTTTGAACTTCGAGAGTCAAATATGC
CTGGGGCAGGACTAGGAATATGGACCAAAAGGAAGATCGAAGTAGGTGAAAAGTTTGGGCCTTATGTGGGAGAGCAGAGGTCAAACCTGA
AAGACCCCAGTTATGGATGGGAGATCTTAGACGAATTTTACAATGTGAAGTTCTGCATAGATGCCAGTCAACCAGATGTTGGAAGCTGGC
TCAAGTACATTAGATTCGCTGGCTGTTATGATCAGCACAACCTTGTTGCATGCCAGATAAATGATCAGATATTCTATAGAGTAGTTGCAG
ACATTGCGCCGGGAGAGGAGCTTCTGCTGTTCATGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCCACGCTCAAAGCT
TGGATTCTGCCGTGCCACTCACGAATGGCGACACAGAAGACGATGCTGACAAAATGCACGTTGATAGGGAGTTTGCTGTTGTAACAGATA
TGAAAAACAGTAGCTCCGTATCGAATACATTGACAAATGGATGTGTCATCAATGGACATTTGGACTTCCCCTCCACGACCCCGCTCAGTG
GGATGGAAAGCAGGAATGGCCAGTGCTTGACAGGAACTAACGGAATTAGCAGTGGATTAGCCCCAGGACAGCCGTTTCCGAGTAGCCAGG
GTTCTCTCTGCATTAGTGGGACTGAGGAGCCAGAGAAGACCCTGAGAGCTAACCCTGAGTTGTGCGGTTCTCTGCACCTGAACGGGAGTC
CAAGTAGCTGCATAGCCAGTAGGCCTTCCTGGGTGGAAGACATTGGGGATAACCTGTACTATGGACACTACCACGGGTTTGGGGACACTG
CTGAAAGCATCCCAGAACTGAACAGTGTGGTCGAGCATTCCAAGTCCGTGAAGGTGCAGGAGCGGTACGACAGTGCCGTGCTGGGCACCA
TGCACCTGCACCACGGCTCCTAGAGACGCTGACCTGGCTCTCGGAAACGCAGGAGTCCTTCCTGGTAGCCAGCTCAGAATACCCATGTAG
CAGCAACTTGAACGAATGTCACAACTTGTACGTTTTTTATATACTTCAACTTTCTGAAAAAGTAAACTTCGACAAGTTCCCAGCAACTGC
TTGTTTGTGCATGAGTAGGGCTTACTAAGTGCATAGATGTTTCTACAGTGAGGTGTCCTTTTTATAAGGTGCACTTTTGGAGTTTTTCTG
ATGCCAATCTCAACATTGTCTTTTTAATACTGTCACCAGATATTGCCATTTTTCTTTTTGTTAAAAGATTATATGATCAAGATAAATTGG
GGTGGTAAATCAGGTGCCTGGTAATTTATCTCTTTGCACATGGGCATCATTTTAAAAAGCTTGCTTCCACTCTTTTCTGTAGAATTTGAC
GGAACACAGCTATTTCCCTATGCAAGGTACAGCCTTACAAAGATTTCTGCAGTGATTTGTGTGAAGAAGAGAACGTTTGTCTTTTTCAAT
GAAGCTTTGCAGATCACCATGTGGTTGAAGGTTTTAGTTGTGGACACAGTGGTCCCTCCTTAATGATGAAGATCACTGCCTTGGGCTTCA
TGGAAAACAGGCCCAGCCTGGGGCTGCGTTTGGATTTATTGTTTTTATTCCACACTTCCTACTTGGTCTCTGGAAGTTTTACCACATGTA
ACAGATTCCTTTATATGTAGTGGAAATCACTATTTGTAGAAACTGTCAGGTCAAAATATTTAACTGACTGTTGACATGTATTTTCTTTTT
TCCTTGTTTTTGTTTTTTGGGGTTTTCTGCTTTAAGATATATACCACTATGTATATCCAGTTAACTGAGAGAATTTTGACTCTCTTAATA
AAACTGCATTAAGTTTTTGATTTTGTAGAAATTAGCTTTTGTCTAGGCAACTAGTGGTTATACTCTGCAAATATTGTAATGAATTTTTAC
TTTTTTGATTTTTGTAATAAAAATTGGTGCAGATAAAATGTCAAATGAACAAACCAGTGTTCTAAGAGTGTTACTAACATTTTGTTCTAA

>52486_52486_4_MECOM-ANKRD10_MECOM_chr3_168849217_ENST00000494292_ANKRD10_chr13_111536140_ENST00000267339_length(amino acids)=394AA_BP=204
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEILDEFYNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRVVADIA
PGEELLLFMKSEDYPHETMAPDIHAQSLDSAVPLTNGDTEDDADKMHVDREFAVVTDMKNSSSVSNTLTNGCVINGHLDFPSTTPLSGME
SRNGQCLTGTNGISSGLAPGQPFPSSQGSLCISGTEEPEKTLRANPELCGSLHLNGSPSSCIASRPSWVEDIGDNLYYGHYHGFGDTAES

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MECOM-ANKRD10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMECOMchr3:168849217chr13:111536140ENST00000264674-417189_44080.333333333333331117.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:168849217chr13:111536140ENST00000392736-316189_44016.3333333333333321052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:168849217chr13:111536140ENST00000433243-417189_44016.3333333333333321053.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:168849217chr13:111536140ENST00000464456-315189_44016.3333333333333321043.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:168849217chr13:111536140ENST00000468789-316189_44016.3333333333333321052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:168849217chr13:111536140ENST00000472280-316189_44016.3333333333333321053.0MAPK9%2C SMAD3 and probably SUV39H1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MECOM-ANKRD10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MECOM-ANKRD10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMECOMC4225221RADIOULNAR SYNOSTOSIS WITH AMEGAKARYOCYTIC THROMBOCYTOPENIA 23GENOMICS_ENGLAND;UNIPROT
HgeneMECOMC0006142Malignant neoplasm of breast1CTD_human
HgeneMECOMC0007102Malignant tumor of colon1CTD_human
HgeneMECOMC0009375Colonic Neoplasms1CTD_human
HgeneMECOMC0023448Lymphoid leukemia1CTD_human
HgeneMECOMC0023466Leukemia, Monocytic, Chronic1CTD_human
HgeneMECOMC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneMECOMC0023470Myeloid Leukemia1CTD_human
HgeneMECOMC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneMECOMC0027022Myeloproliferative disease1CTD_human
HgeneMECOMC0027439Nasopharyngeal Neoplasms1CTD_human
HgeneMECOMC0030312Pancytopenia1CTD_human
HgeneMECOMC0038002Splenomegaly1CTD_human
HgeneMECOMC0238301Cancer of Nasopharynx1CTD_human
HgeneMECOMC0678222Breast Carcinoma1CTD_human
HgeneMECOMC0919267ovarian neoplasm1CTD_human
HgeneMECOMC1140680Malignant neoplasm of ovary1CTD_human
HgeneMECOMC1257931Mammary Neoplasms, Human1CTD_human
HgeneMECOMC1458155Mammary Neoplasms1CTD_human
HgeneMECOMC1854273Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia1GENOMICS_ENGLAND;ORPHANET
HgeneMECOMC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneMECOMC2931456Prostate cancer, familial1CTD_human
HgeneMECOMC4704874Mammary Carcinoma, Human1CTD_human
HgeneMECOMC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human