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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EXT2-TTC17 (FusionGDB2 ID:HG2132TG55761)

Fusion Gene Summary for EXT2-TTC17

Fusion gene summary

Fusion gene information	Fusion gene name: EXT2-TTC17
	Fusion gene ID: hg2132tg55761
		Hgene	Tgene
	Gene symbol	EXT2	TTC17
	Gene ID	2132	55761
	Gene name	exostosin glycosyltransferase 2	tetratricopeptide repeat domain 17
	Synonyms	SOTV\|SSMS	-
	Cytomap	('EXT2')('TTC17') 11p11.2	11p12-p11.2
	Type of gene	protein-coding	protein-coding
	Description	exostosin-2N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferaseglucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferasemultiple exostoses protein 2multiple exostosis 2putativ	tetratricopeptide repeat protein 17TPR repeat protein 17
	Modification date	20200313	20200313
	UniProtAcc	Q93063	.
	Ensembl transtripts involved in fusion gene	ENST00000343631, ENST00000358681, ENST00000395673, ENST00000533608, ENST00000529186,
Fusion gene scores	* DoF score	8 X 6 X 8=384	10 X 10 X 4=400
	# samples	9	11
	** MAII score	log2(9/384*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/400*10)=-1.86249647625006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EXT2 [Title/Abstract] AND TTC17 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EXT2(44151688)-TTC17(43436140), # samples:2
Anticipated loss of major functional domain due to fusion event.	EXT2-TTC17 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EXT2-TTC17 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EXT2	GO:0006024	glycosaminoglycan biosynthetic process	12907669
Hgene	EXT2	GO:0033692	cellular polysaccharide biosynthetic process	12907669

Fusion gene breakpoints across EXT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TTC17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-1842-01A	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+

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Fusion Gene ORF analysis for EXT2-TTC17

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000343631	ENST00000526774	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
5CDS-3UTR	ENST00000358681	ENST00000526774	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
5CDS-3UTR	ENST00000395673	ENST00000526774	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
5CDS-3UTR	ENST00000533608	ENST00000526774	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
In-frame	ENST00000343631	ENST00000039989	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
In-frame	ENST00000343631	ENST00000299240	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
In-frame	ENST00000358681	ENST00000039989	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
In-frame	ENST00000358681	ENST00000299240	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
In-frame	ENST00000395673	ENST00000039989	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
In-frame	ENST00000395673	ENST00000299240	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
In-frame	ENST00000533608	ENST00000039989	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
In-frame	ENST00000533608	ENST00000299240	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
intron-3CDS	ENST00000529186	ENST00000039989	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
intron-3CDS	ENST00000529186	ENST00000299240	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+
intron-3UTR	ENST00000529186	ENST00000526774	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000533608	EXT2	chr11	44151688	+	ENST00000299240	TTC17	chr11	43436140	+	3068	1507	4	2313	769
ENST00000533608	EXT2	chr11	44151688	+	ENST00000039989	TTC17	chr11	43436140	+	3898	1507	4	2868	954
ENST00000358681	EXT2	chr11	44151688	+	ENST00000299240	TTC17	chr11	43436140	+	2900	1339	34	2145	703
ENST00000358681	EXT2	chr11	44151688	+	ENST00000039989	TTC17	chr11	43436140	+	3730	1339	34	2700	888
ENST00000395673	EXT2	chr11	44151688	+	ENST00000299240	TTC17	chr11	43436140	+	2889	1328	38	2134	698
ENST00000395673	EXT2	chr11	44151688	+	ENST00000039989	TTC17	chr11	43436140	+	3719	1328	38	2689	883
ENST00000343631	EXT2	chr11	44151688	+	ENST00000299240	TTC17	chr11	43436140	+	2863	1302	12	2108	698
ENST00000343631	EXT2	chr11	44151688	+	ENST00000039989	TTC17	chr11	43436140	+	3693	1302	12	2663	883

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000533608	ENST00000299240	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+	0.000486536	0.9995135
ENST00000533608	ENST00000039989	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+	0.000437258	0.9995627
ENST00000358681	ENST00000299240	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+	0.00037824	0.99962175
ENST00000358681	ENST00000039989	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+	0.000372702	0.99962723
ENST00000395673	ENST00000299240	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+	0.000180909	0.9998191
ENST00000395673	ENST00000039989	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+	0.000134136	0.9998659
ENST00000343631	ENST00000299240	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+	0.000176761	0.9998233
ENST00000343631	ENST00000039989	EXT2	chr11	44151688	+	TTC17	chr11	43436140	+	0.000131913	0.99986804

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Fusion Genomic Features for EXT2-TTC17

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
EXT2	chr11	44151688	+	TTC17	chr11	43436139	+	0.001460846	0.9985392
EXT2	chr11	44151688	+	TTC17	chr11	43436139	+	0.001460846	0.9985392

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EXT2-TTC17

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:44151688/chr11:43436140)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EXT2 Q93063	.
FUNCTION: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269\|PubMed:22660413}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000343631

1_25

391

719.0

Topological domain

Cytoplasmic

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000358681

1_25

391

729.0

Topological domain

Cytoplasmic

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000395673

1_25

424

752.0

Topological domain

Cytoplasmic

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000533608

1_25

391

719.0

Topological domain

Cytoplasmic

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000343631

26_46

391

719.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000358681

26_46

391

729.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000395673

26_46

424

752.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000533608

26_46

391

719.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

TTC17

chr11:44151688

chr11:43436140

ENST00000039989

1014_1048

688

1142.0

Repeat

Note=TPR 4

Tgene

TTC17

chr11:44151688

chr11:43436140

ENST00000039989

1051_1084

688

1142.0

Repeat

Note=TPR 5

Tgene

TTC17

chr11:44151688

chr11:43436140

ENST00000039989

1085_1118

688

1142.0

Repeat

Note=TPR 6

Tgene

TTC17

chr11:44151688

chr11:43436140

ENST00000039989

689_722

688

1142.0

Repeat

Note=TPR 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000343631

517_522

391

719.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000343631

538_540

391

719.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000343631

624_628

391

719.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000343631

662_673

391

719.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000358681

517_522

391

729.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000358681

538_540

391

729.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000358681

624_628

391

729.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000358681

662_673

391

729.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000395673

517_522

424

752.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000395673

538_540

424

752.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000395673

624_628

424

752.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000395673

662_673

424

752.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000533608

517_522

391

719.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000533608

538_540

391

719.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000533608

624_628

391

719.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000533608

662_673

391

719.0

Region

Substrate binding

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000343631

47_718

391

719.0

Topological domain

Lumenal

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000358681

47_718

391

729.0

Topological domain

Lumenal

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000395673

47_718

424

752.0

Topological domain

Lumenal

Hgene

EXT2

chr11:44151688

chr11:43436140

ENST00000533608

47_718

391

719.0

Topological domain

Lumenal

Tgene

TTC17

chr11:44151688

chr11:43436140

ENST00000039989

340_382

688

1142.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TTC17

chr11:44151688

chr11:43436140

ENST00000039989

295_328

688

1142.0

Repeat

Note=TPR 1

Tgene

TTC17

chr11:44151688

chr11:43436140

ENST00000039989

619_652

688

1142.0

Repeat

Note=TPR 2

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Fusion Gene Sequence for EXT2-TTC17

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>28027_28027_1_EXT2-TTC17_EXT2_chr11_44151688_ENST00000343631_TTC17_chr11_43436140_ENST00000039989_length(transcript)=3693nt_BP=1302nt
AGCCACAGGGATCTGATTCCTCCCAGGGGGATGTCCTGCGCCTCAGGGTCCGGTGGTGGCCTGCGGCATCCCTTGCGGTGCCAGAAGCCG
TGGGACGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATATCCGGGGTCCTGCCCTCATCCCAAGA
ATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTGCCACTGGCATGTTTCAGTTTTGGCCC
CATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTGTTAGGCTGCCAGCCGACAGTCCCATC
CCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCAACCCAAAGAACAAAATCAAGGTGTAT
ATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGGAGTATAATGAACTGCTCATGGCCATC
TCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATGTGCTTAACCAGAACACACTGCGCATC
AAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGTTCAACATGTTGCCTGGAGGTCCCCCA
GATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTACGTGGACTTACCGGCAAGGCTACGAT
GTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTCCACGGCAATACTTCCTCCTGTCATCT
CAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGTCAGTGTTAGTACTCGATAAATGCACC
AACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACCCACAGGTGCTACAGGAGGCTACTTTC
TGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCTGTGTCCCGGTTGTCATTGCAGACTCC
TATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAAAGATGTCAGATGTGTACAGTATTTTG
CAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTTTTTGAGCCTGGGAAATGCTTACCTTGCTCTGAAGAAT
ATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATGTCCAGAGTGTGAAAACAGCCTGAAGTTGATCCGCTGT
ATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTACGGTGGTTGAGGAGAGCAATGGTTCTGATGAGATGGAG
AATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGCATGGCCTTTGGAAGGCTTTGGGGGTGCA
CTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCAGGATGGAGTGGCCAGAAGCTCTTGCTAT
GGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGTAAAGAAACCCAAAGGAGATCATAAGAAA
ACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCTAGAGATCACTGGCCCCAAGGTGGCATCT
CCTGGGCCACAAGGAAAAAAACGTGACTACCAGCGTCTGGGATGGCCCAGCCCGGACGAATGCCTCAAACTCCGCTGGGTAGAGCTGACT
GCCATCGTGAGTACCTGGCTTGCAGTTTCTTCAAAAAACATTGACATCACAGAACACATAGATTTTGCCACCCCTATACAGCAGCCAGCA
ATGGAGCCTCTTTGCAATGGCAATCTCCCCACGAGTATGCATACCCTGGACCACTTGCATGGGGTTTCCAACCGAGCCAGCCTGCACTAC
ACAGGGGAGAGTCAGTTAACAGAGGTATTACAAAATCTCGGCAAAGACCAATATCCACAACAGTCGCTTGAACAGATTGGCACCCGAATT
GCCAAAGTTTTGGAAAAGAACCAGACGTCCTGGGTCCTCTCCAGCATGGCAGCCCTCTACTGGAGGGTGAAAGGCCAAGGAAAGAAGGCA
ATCGACTGCCTCCGCCAGGCTCTGCACTATGCGCCACACCAGATGAAGGATGTGCCCCTGATTAGCCTGGCCAACATCTTGCACAATGCC
AAGCTCTGGAATGACGCCGTCATAGTAGCCACCATGGCAGTAGAGATCGCACCACACTTTGCTGTGAACCACTTCACTCTGGGCAATGTC
TACGTGGCAATGGAAGAATTTGAAAAAGCACTGGTGTGGTATGAATCCACATTGAAGCTTCAGCCCGAGTTTGTCCCAGCCAAGAACCGA
ATCCAGACCATCCAGTGTCACTTAATGCTGAAGAAGGGACGGCGCTCTCCTTAGTGCACTTCTTCCTTCTCTCTTTCTCTTTACTCATGC
TCTAAAAAAAAAGAATAAGAAAAGAAACCAATCATTGTCAGTATCTACTATTAATGATGTGTGTGAAAATAACTAAGACTTATAACAGGA
CTTTTACATATGTGGGAATTGGTTTGTTTTTGTTTTTACGTTTCTCCTTTCCCCCAACCAACCTCAGAAGAGGCACCTTCAGAAACACAC
ATTTCTTAAAAGGAAAGTGCAGCTTCAAGATATTGTGTAAATACTGAGCCAAGACATTTCTGGAGCTGTGCTCTGTCTCCAAAAACCTCA
ATGCCTTTAGGGCTTTTCTCAGTGGTCCAGCTAGCCTTCTCTTTGGAGGAGGATGAAGCCGCATTGCACATTCTCTGCTTCCTGTCGTAG
CCTCTGTTGTCAATGGAAATGCGGAAGCCCATCTGGTGCCCGTCAGTGAGAAGCAACGTTCTGCGCTCTCTCCGTTAGACCTCCATGCTG
TCCCCAGTCTTGTCCATTCCATGCTGCTGTGTTACAAACTCTCAGAGGTAGTTTGCAGGGGAGGAAGGGGAATATGATTTTAAAAACAAA
ATATTTACAACAACAAAAATTCTTAGGATCACCTGACCTTTGTAATGTTATTTATGTTGGGGAGGGAGGGGGGCTGAGAAGGGGAAATCA
GCAGTGTGCAACATCTTTATAATTTGTACTTTAATTACAAATCACAAGGAAACCAATAAGTTGAAATCCTATATAACAGGTTTATATATA
TAGAATATGTATATTTGAAGCCCTCTACAGACTGAGTCTATGTTTTACTAATTCTTTGTTCACTGTGTTACCCATCTTGGAATAAGTTGT
GAATGTCAGCTCCCTCTCTCTGAGGCCTCCAGACTTAGCTCCTCAGGAGGGTAATGAGCCAAGGTTGAGTGTTTCCATACAATGCTTTTA
CCTTTGATCCCAGGAGAATCAGAAACTCCAACATTTTGGAATCTTCAAGGGCACATACTGAGAAAAAAAATAAAATTGTTTATGAGCAAA
ATA

>28027_28027_1_EXT2-TTC17_EXT2_chr11_44151688_ENST00000343631_TTC17_chr11_43436140_ENST00000039989_length(amino acids)=883AA_BP=429
MIPPRGMSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIE
SSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSD
YYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIP
VYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVL
RGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALKNISGA
LEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMK
GRRLDLQGIRVLKKGPQDGVARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVASPGPQ
GKKRDYQRLGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASLHYTGES
QLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWN
DAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRSP

--------------------------------------------------------------
>28027_28027_2_EXT2-TTC17_EXT2_chr11_44151688_ENST00000343631_TTC17_chr11_43436140_ENST00000299240_length(transcript)=2863nt_BP=1302nt
AGCCACAGGGATCTGATTCCTCCCAGGGGGATGTCCTGCGCCTCAGGGTCCGGTGGTGGCCTGCGGCATCCCTTGCGGTGCCAGAAGCCG
TGGGACGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATATCCGGGGTCCTGCCCTCATCCCAAGA
ATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTGCCACTGGCATGTTTCAGTTTTGGCCC
CATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTGTTAGGCTGCCAGCCGACAGTCCCATC
CCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCAACCCAAAGAACAAAATCAAGGTGTAT
ATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGGAGTATAATGAACTGCTCATGGCCATC
TCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATGTGCTTAACCAGAACACACTGCGCATC
AAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGTTCAACATGTTGCCTGGAGGTCCCCCA
GATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTACGTGGACTTACCGGCAAGGCTACGAT
GTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTCCACGGCAATACTTCCTCCTGTCATCT
CAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGTCAGTGTTAGTACTCGATAAATGCACC
AACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACCCACAGGTGCTACAGGAGGCTACTTTC
TGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCTGTGTCCCGGTTGTCATTGCAGACTCC
TATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAAAGATGTCAGATGTGTACAGTATTTTG
CAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTTTTTGAGCCTGGGAAATGCTTACCTTGCTCTGAAGAAT
ATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATGTCCAGAGTGTGAAAACAGCCTGAAGTTGATCCGCTGT
ATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTAATTGTCATGAGAAAACCCTGGACAACAGCCATGACAAA
CAGAAATATTTTGACAACTCACAGTCACTGGATGCTGCTGAAGAAGAGCCCTCTGAGAGAGGAACAGAGGAGGACCCTGTATTCTCTGTT
GAGAATTCAGGGAGGGACTCAGATGCCCTTAGACTTGAAAGTACGGTGGTTGAGGAGAGCAATGGTTCTGATGAGATGGAGAATTCAGAT
GAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGCATGGCCTTTGGAAGGCTTTGGGGGTGCACTAGAGATG
AAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCAGGATGGAGTGGCCAGAAGCTCTTGCTATGGAGACTGC
AGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGTAAAGAAACCCAAAGGAGATCATAAGAAAACTCCTGGG
AAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCTAGAGATCACTGGCCCCAAGGTGGCATCTCCTGGGCCA
CAAGGGCTACTAGACTGGAAGACCAGGAAAGTGCCATAGACATAATGTAACTGGATTTCAGCAAGGCATTTAACAGAGCCTCTTATGATA
TCCTTGTGAACCAGATGGAGAGATGTGGGCTTGAAGCCTTCCCATTGCCTACAGGATAAAATTCAAACTTCCTAGTGTGGTGTACAAGAC
CCTTTACAGCCCGCCTCTGTGTACCCTTCAACACCATTCTCTGAACCAACCATGCTCATGTTTTTACCTCAGTGCCTTTGCACATGCTAT
TCCCTCTGCCTGGAATGCCCTGTGCCCCCTCTGCCCTCTGCCGTGCTAAAATATCACTCATCCTTAAACTTCAAAATCAAGTGCCATCTC
TTCCTTGTTACCTTCAGGCAGAATTAGTTACTCTTTCCTCTGTGCAATTGTTCTATATCTTCGCTCTAGCTCTTTTCCTGTTGTATTGTA
ATGATTTGTTTATGTTTACCTTCCTTACTAGACTGTGAGCTCAAGAGCAGGCCGTCTTAATTATTCCTTTCTGTACCCCTAGTGTCTTTT
ATGGTTCTCAGCCCCTTATAACAGGTGCTCAATAAATATTTTTCAAATGAAATTATTAAATGTAAAAGAAAATTAAGATTTTTTGTGAAA
ATTATGGCTTATTTAAGTTATTAATTTAAACAGAGTTAATTTGAAACTCTTCCAAAACTGTTCCTTTCTGTTTTGTTAAAATCTCAATCT
AAACCCCTGCCTGTACCTCAAACAGTTTTCTACTGTTCGTAAATTCCTATAATATAAAAAGCGCTATACAGAA

>28027_28027_2_EXT2-TTC17_EXT2_chr11_44151688_ENST00000343631_TTC17_chr11_43436140_ENST00000299240_length(amino acids)=698AA_BP=429
MIPPRGMSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIE
SSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSD
YYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIP
VYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVL
RGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALKNISGA
LEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGNCHEKTLDNSHDKQKYFDNSQSLDAAEEEPSERGTEEDPVFSVENSG
RDSDALRLESTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGDCRSED
DEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVASPGPQGLLDWKTRKVP

--------------------------------------------------------------
>28027_28027_3_EXT2-TTC17_EXT2_chr11_44151688_ENST00000358681_TTC17_chr11_43436140_ENST00000039989_length(transcript)=3730nt_BP=1339nt
CTCGCCAGCCCAGACTCGGCCCTGGCAGTGGCGGCTGGCGATTCGGACCGATCCGACCTGGGCGGAGGTGGCCCGCGCCCCGCGGCATGA
GCCGGTGACCAAGCTCGGGGCCGAGCGGGAGGCAGCCGTGGCCGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGT
CAAGTATAATATCCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCT
GGGCCTCATTGCCACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGA
TGTGCCGGTTGTTAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCG
CTGTGGCTTCAACCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACAC
CATCTCCCGGGAGTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCC
CTCCATCGATGTGCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAA
TCACCTGTTGTTCAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGG
CGGCTTTTCTACGTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAA
AGGACCAGGTCCACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAA
ACATGGAGAGTCAGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGT
CTTCGATTACCCACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTT
ACAAGCTGGCTGTGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGT
ACCAGAAGAAAAGATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTT
TTTGAGCCTGGGAAATGCTTACCTTGCTCTGAAGAATATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATG
TCCAGAGTGTGAAAACAGCCTGAAGTTGATCCGCTGTATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTAC
GGTGGTTGAGGAGAGCAATGGTTCTGATGAGATGGAGAATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATT
TCAACAGGCATGGCCTTTGGAAGGCTTTGGGGGTGCACTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAA
AGGTCCCCAGGATGGAGTGGCCAGAAGCTCTTGCTATGGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGT
CAAACGTGTAAAGAAACCCAAAGGAGATCATAAGAAAACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCA
AGCAAACCTAGAGATCACTGGCCCCAAGGTGGCATCTCCTGGGCCACAAGGAAAAAAACGTGACTACCAGCGTCTGGGATGGCCCAGCCC
GGACGAATGCCTCAAACTCCGCTGGGTAGAGCTGACTGCCATCGTGAGTACCTGGCTTGCAGTTTCTTCAAAAAACATTGACATCACAGA
ACACATAGATTTTGCCACCCCTATACAGCAGCCAGCAATGGAGCCTCTTTGCAATGGCAATCTCCCCACGAGTATGCATACCCTGGACCA
CTTGCATGGGGTTTCCAACCGAGCCAGCCTGCACTACACAGGGGAGAGTCAGTTAACAGAGGTATTACAAAATCTCGGCAAAGACCAATA
TCCACAACAGTCGCTTGAACAGATTGGCACCCGAATTGCCAAAGTTTTGGAAAAGAACCAGACGTCCTGGGTCCTCTCCAGCATGGCAGC
CCTCTACTGGAGGGTGAAAGGCCAAGGAAAGAAGGCAATCGACTGCCTCCGCCAGGCTCTGCACTATGCGCCACACCAGATGAAGGATGT
GCCCCTGATTAGCCTGGCCAACATCTTGCACAATGCCAAGCTCTGGAATGACGCCGTCATAGTAGCCACCATGGCAGTAGAGATCGCACC
ACACTTTGCTGTGAACCACTTCACTCTGGGCAATGTCTACGTGGCAATGGAAGAATTTGAAAAAGCACTGGTGTGGTATGAATCCACATT
GAAGCTTCAGCCCGAGTTTGTCCCAGCCAAGAACCGAATCCAGACCATCCAGTGTCACTTAATGCTGAAGAAGGGACGGCGCTCTCCTTA
GTGCACTTCTTCCTTCTCTCTTTCTCTTTACTCATGCTCTAAAAAAAAAGAATAAGAAAAGAAACCAATCATTGTCAGTATCTACTATTA
ATGATGTGTGTGAAAATAACTAAGACTTATAACAGGACTTTTACATATGTGGGAATTGGTTTGTTTTTGTTTTTACGTTTCTCCTTTCCC
CCAACCAACCTCAGAAGAGGCACCTTCAGAAACACACATTTCTTAAAAGGAAAGTGCAGCTTCAAGATATTGTGTAAATACTGAGCCAAG
ACATTTCTGGAGCTGTGCTCTGTCTCCAAAAACCTCAATGCCTTTAGGGCTTTTCTCAGTGGTCCAGCTAGCCTTCTCTTTGGAGGAGGA
TGAAGCCGCATTGCACATTCTCTGCTTCCTGTCGTAGCCTCTGTTGTCAATGGAAATGCGGAAGCCCATCTGGTGCCCGTCAGTGAGAAG
CAACGTTCTGCGCTCTCTCCGTTAGACCTCCATGCTGTCCCCAGTCTTGTCCATTCCATGCTGCTGTGTTACAAACTCTCAGAGGTAGTT
TGCAGGGGAGGAAGGGGAATATGATTTTAAAAACAAAATATTTACAACAACAAAAATTCTTAGGATCACCTGACCTTTGTAATGTTATTT
ATGTTGGGGAGGGAGGGGGGCTGAGAAGGGGAAATCAGCAGTGTGCAACATCTTTATAATTTGTACTTTAATTACAAATCACAAGGAAAC
CAATAAGTTGAAATCCTATATAACAGGTTTATATATATAGAATATGTATATTTGAAGCCCTCTACAGACTGAGTCTATGTTTTACTAATT
CTTTGTTCACTGTGTTACCCATCTTGGAATAAGTTGTGAATGTCAGCTCCCTCTCTCTGAGGCCTCCAGACTTAGCTCCTCAGGAGGGTA
ATGAGCCAAGGTTGAGTGTTTCCATACAATGCTTTTACCTTTGATCCCAGGAGAATCAGAAACTCCAACATTTTGGAATCTTCAAGGGCA
CATACTGAGAAAAAAAATAAAATTGTTTATGAGCAAAATA

>28027_28027_3_EXT2-TTC17_EXT2_chr11_44151688_ENST00000358681_TTC17_chr11_43436140_ENST00000039989_length(amino acids)=888AA_BP=434
MAIRTDPTWAEVARAPRHEPVTKLGAEREAAVAEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFW
PHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMA
ISDSDYYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGY
DVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEAT
FCVVLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALK
NISGALEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGG
ALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVA
SPGPQGKKRDYQRLGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASLH
YTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHN
AKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRSP

--------------------------------------------------------------
>28027_28027_4_EXT2-TTC17_EXT2_chr11_44151688_ENST00000358681_TTC17_chr11_43436140_ENST00000299240_length(transcript)=2900nt_BP=1339nt
CTCGCCAGCCCAGACTCGGCCCTGGCAGTGGCGGCTGGCGATTCGGACCGATCCGACCTGGGCGGAGGTGGCCCGCGCCCCGCGGCATGA
GCCGGTGACCAAGCTCGGGGCCGAGCGGGAGGCAGCCGTGGCCGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGT
CAAGTATAATATCCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCT
GGGCCTCATTGCCACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGA
TGTGCCGGTTGTTAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCG
CTGTGGCTTCAACCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACAC
CATCTCCCGGGAGTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCC
CTCCATCGATGTGCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAA
TCACCTGTTGTTCAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGG
CGGCTTTTCTACGTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAA
AGGACCAGGTCCACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAA
ACATGGAGAGTCAGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGT
CTTCGATTACCCACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTT
ACAAGCTGGCTGTGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGT
ACCAGAAGAAAAGATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTT
TTTGAGCCTGGGAAATGCTTACCTTGCTCTGAAGAATATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATG
TCCAGAGTGTGAAAACAGCCTGAAGTTGATCCGCTGTATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTAA
TTGTCATGAGAAAACCCTGGACAACAGCCATGACAAACAGAAATATTTTGACAACTCACAGTCACTGGATGCTGCTGAAGAAGAGCCCTC
TGAGAGAGGAACAGAGGAGGACCCTGTATTCTCTGTTGAGAATTCAGGGAGGGACTCAGATGCCCTTAGACTTGAAAGTACGGTGGTTGA
GGAGAGCAATGGTTCTGATGAGATGGAGAATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGC
ATGGCCTTTGGAAGGCTTTGGGGGTGCACTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCA
GGATGGAGTGGCCAGAAGCTCTTGCTATGGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGT
AAAGAAACCCAAAGGAGATCATAAGAAAACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCT
AGAGATCACTGGCCCCAAGGTGGCATCTCCTGGGCCACAAGGGCTACTAGACTGGAAGACCAGGAAAGTGCCATAGACATAATGTAACTG
GATTTCAGCAAGGCATTTAACAGAGCCTCTTATGATATCCTTGTGAACCAGATGGAGAGATGTGGGCTTGAAGCCTTCCCATTGCCTACA
GGATAAAATTCAAACTTCCTAGTGTGGTGTACAAGACCCTTTACAGCCCGCCTCTGTGTACCCTTCAACACCATTCTCTGAACCAACCAT
GCTCATGTTTTTACCTCAGTGCCTTTGCACATGCTATTCCCTCTGCCTGGAATGCCCTGTGCCCCCTCTGCCCTCTGCCGTGCTAAAATA
TCACTCATCCTTAAACTTCAAAATCAAGTGCCATCTCTTCCTTGTTACCTTCAGGCAGAATTAGTTACTCTTTCCTCTGTGCAATTGTTC
TATATCTTCGCTCTAGCTCTTTTCCTGTTGTATTGTAATGATTTGTTTATGTTTACCTTCCTTACTAGACTGTGAGCTCAAGAGCAGGCC
GTCTTAATTATTCCTTTCTGTACCCCTAGTGTCTTTTATGGTTCTCAGCCCCTTATAACAGGTGCTCAATAAATATTTTTCAAATGAAAT
TATTAAATGTAAAAGAAAATTAAGATTTTTTGTGAAAATTATGGCTTATTTAAGTTATTAATTTAAACAGAGTTAATTTGAAACTCTTCC
AAAACTGTTCCTTTCTGTTTTGTTAAAATCTCAATCTAAACCCCTGCCTGTACCTCAAACAGTTTTCTACTGTTCGTAAATTCCTATAAT
ATAAAAAGCGCTATACAGAA

>28027_28027_4_EXT2-TTC17_EXT2_chr11_44151688_ENST00000358681_TTC17_chr11_43436140_ENST00000299240_length(amino acids)=703AA_BP=434
MAIRTDPTWAEVARAPRHEPVTKLGAEREAAVAEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFW
PHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMA
ISDSDYYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGY
DVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEAT
FCVVLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALK
NISGALEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGNCHEKTLDNSHDKQKYFDNSQSLDAAEEEPSERGTEEDPVFS
VENSGRDSDALRLESTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGD
CRSEDDEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVASPGPQGLLDWKTRKVP

--------------------------------------------------------------
>28027_28027_5_EXT2-TTC17_EXT2_chr11_44151688_ENST00000395673_TTC17_chr11_43436140_ENST00000039989_length(transcript)=3719nt_BP=1328nt
TCCCTTCCTGCTGCCACCTTCCCGCCAGCCACAGGGATCTGATTCCTCCCAGGGGGATGTCCTGCGCCTCAGGGTCCGGTGGTGGCCTGC
GGCATCCCTTGCGGTGCCAGAAGCCGTGGGACGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATA
TCCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTG
CCACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTG
TTAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCA
ACCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGG
AGTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATG
TGCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGT
TCAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTA
CGTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTC
CACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGT
CAGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACC
CACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCT
GTGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAA
AGATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTTTTTGAGCCTGG
GAAATGCTTACCTTGCTCTGAAGAATATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATGTCCAGAGTGTG
AAAACAGCCTGAAGTTGATCCGCTGTATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTACGGTGGTTGAGG
AGAGCAATGGTTCTGATGAGATGGAGAATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGCAT
GGCCTTTGGAAGGCTTTGGGGGTGCACTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCAGG
ATGGAGTGGCCAGAAGCTCTTGCTATGGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGTAA
AGAAACCCAAAGGAGATCATAAGAAAACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCTAG
AGATCACTGGCCCCAAGGTGGCATCTCCTGGGCCACAAGGAAAAAAACGTGACTACCAGCGTCTGGGATGGCCCAGCCCGGACGAATGCC
TCAAACTCCGCTGGGTAGAGCTGACTGCCATCGTGAGTACCTGGCTTGCAGTTTCTTCAAAAAACATTGACATCACAGAACACATAGATT
TTGCCACCCCTATACAGCAGCCAGCAATGGAGCCTCTTTGCAATGGCAATCTCCCCACGAGTATGCATACCCTGGACCACTTGCATGGGG
TTTCCAACCGAGCCAGCCTGCACTACACAGGGGAGAGTCAGTTAACAGAGGTATTACAAAATCTCGGCAAAGACCAATATCCACAACAGT
CGCTTGAACAGATTGGCACCCGAATTGCCAAAGTTTTGGAAAAGAACCAGACGTCCTGGGTCCTCTCCAGCATGGCAGCCCTCTACTGGA
GGGTGAAAGGCCAAGGAAAGAAGGCAATCGACTGCCTCCGCCAGGCTCTGCACTATGCGCCACACCAGATGAAGGATGTGCCCCTGATTA
GCCTGGCCAACATCTTGCACAATGCCAAGCTCTGGAATGACGCCGTCATAGTAGCCACCATGGCAGTAGAGATCGCACCACACTTTGCTG
TGAACCACTTCACTCTGGGCAATGTCTACGTGGCAATGGAAGAATTTGAAAAAGCACTGGTGTGGTATGAATCCACATTGAAGCTTCAGC
CCGAGTTTGTCCCAGCCAAGAACCGAATCCAGACCATCCAGTGTCACTTAATGCTGAAGAAGGGACGGCGCTCTCCTTAGTGCACTTCTT
CCTTCTCTCTTTCTCTTTACTCATGCTCTAAAAAAAAAGAATAAGAAAAGAAACCAATCATTGTCAGTATCTACTATTAATGATGTGTGT
GAAAATAACTAAGACTTATAACAGGACTTTTACATATGTGGGAATTGGTTTGTTTTTGTTTTTACGTTTCTCCTTTCCCCCAACCAACCT
CAGAAGAGGCACCTTCAGAAACACACATTTCTTAAAAGGAAAGTGCAGCTTCAAGATATTGTGTAAATACTGAGCCAAGACATTTCTGGA
GCTGTGCTCTGTCTCCAAAAACCTCAATGCCTTTAGGGCTTTTCTCAGTGGTCCAGCTAGCCTTCTCTTTGGAGGAGGATGAAGCCGCAT
TGCACATTCTCTGCTTCCTGTCGTAGCCTCTGTTGTCAATGGAAATGCGGAAGCCCATCTGGTGCCCGTCAGTGAGAAGCAACGTTCTGC
GCTCTCTCCGTTAGACCTCCATGCTGTCCCCAGTCTTGTCCATTCCATGCTGCTGTGTTACAAACTCTCAGAGGTAGTTTGCAGGGGAGG
AAGGGGAATATGATTTTAAAAACAAAATATTTACAACAACAAAAATTCTTAGGATCACCTGACCTTTGTAATGTTATTTATGTTGGGGAG
GGAGGGGGGCTGAGAAGGGGAAATCAGCAGTGTGCAACATCTTTATAATTTGTACTTTAATTACAAATCACAAGGAAACCAATAAGTTGA
AATCCTATATAACAGGTTTATATATATAGAATATGTATATTTGAAGCCCTCTACAGACTGAGTCTATGTTTTACTAATTCTTTGTTCACT
GTGTTACCCATCTTGGAATAAGTTGTGAATGTCAGCTCCCTCTCTCTGAGGCCTCCAGACTTAGCTCCTCAGGAGGGTAATGAGCCAAGG
TTGAGTGTTTCCATACAATGCTTTTACCTTTGATCCCAGGAGAATCAGAAACTCCAACATTTTGGAATCTTCAAGGGCACATACTGAGAA
AAAAAATAAAATTGTTTATGAGCAAAATA

>28027_28027_5_EXT2-TTC17_EXT2_chr11_44151688_ENST00000395673_TTC17_chr11_43436140_ENST00000039989_length(amino acids)=883AA_BP=429
MIPPRGMSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIE
SSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSD
YYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIP
VYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVL
RGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALKNISGA
LEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMK
GRRLDLQGIRVLKKGPQDGVARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVASPGPQ
GKKRDYQRLGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASLHYTGES
QLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWN
DAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRSP

--------------------------------------------------------------
>28027_28027_6_EXT2-TTC17_EXT2_chr11_44151688_ENST00000395673_TTC17_chr11_43436140_ENST00000299240_length(transcript)=2889nt_BP=1328nt
TCCCTTCCTGCTGCCACCTTCCCGCCAGCCACAGGGATCTGATTCCTCCCAGGGGGATGTCCTGCGCCTCAGGGTCCGGTGGTGGCCTGC
GGCATCCCTTGCGGTGCCAGAAGCCGTGGGACGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATA
TCCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTG
CCACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTG
TTAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCA
ACCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGG
AGTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATG
TGCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGT
TCAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTA
CGTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTC
CACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGT
CAGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACC
CACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCT
GTGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAA
AGATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTTTTTGAGCCTGG
GAAATGCTTACCTTGCTCTGAAGAATATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATGTCCAGAGTGTG
AAAACAGCCTGAAGTTGATCCGCTGTATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTAATTGTCATGAGA
AAACCCTGGACAACAGCCATGACAAACAGAAATATTTTGACAACTCACAGTCACTGGATGCTGCTGAAGAAGAGCCCTCTGAGAGAGGAA
CAGAGGAGGACCCTGTATTCTCTGTTGAGAATTCAGGGAGGGACTCAGATGCCCTTAGACTTGAAAGTACGGTGGTTGAGGAGAGCAATG
GTTCTGATGAGATGGAGAATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGCATGGCCTTTGG
AAGGCTTTGGGGGTGCACTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCAGGATGGAGTGG
CCAGAAGCTCTTGCTATGGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGTAAAGAAACCCA
AAGGAGATCATAAGAAAACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCTAGAGATCACTG
GCCCCAAGGTGGCATCTCCTGGGCCACAAGGGCTACTAGACTGGAAGACCAGGAAAGTGCCATAGACATAATGTAACTGGATTTCAGCAA
GGCATTTAACAGAGCCTCTTATGATATCCTTGTGAACCAGATGGAGAGATGTGGGCTTGAAGCCTTCCCATTGCCTACAGGATAAAATTC
AAACTTCCTAGTGTGGTGTACAAGACCCTTTACAGCCCGCCTCTGTGTACCCTTCAACACCATTCTCTGAACCAACCATGCTCATGTTTT
TACCTCAGTGCCTTTGCACATGCTATTCCCTCTGCCTGGAATGCCCTGTGCCCCCTCTGCCCTCTGCCGTGCTAAAATATCACTCATCCT
TAAACTTCAAAATCAAGTGCCATCTCTTCCTTGTTACCTTCAGGCAGAATTAGTTACTCTTTCCTCTGTGCAATTGTTCTATATCTTCGC
TCTAGCTCTTTTCCTGTTGTATTGTAATGATTTGTTTATGTTTACCTTCCTTACTAGACTGTGAGCTCAAGAGCAGGCCGTCTTAATTAT
TCCTTTCTGTACCCCTAGTGTCTTTTATGGTTCTCAGCCCCTTATAACAGGTGCTCAATAAATATTTTTCAAATGAAATTATTAAATGTA
AAAGAAAATTAAGATTTTTTGTGAAAATTATGGCTTATTTAAGTTATTAATTTAAACAGAGTTAATTTGAAACTCTTCCAAAACTGTTCC
TTTCTGTTTTGTTAAAATCTCAATCTAAACCCCTGCCTGTACCTCAAACAGTTTTCTACTGTTCGTAAATTCCTATAATATAAAAAGCGC
TATACAGAA

>28027_28027_6_EXT2-TTC17_EXT2_chr11_44151688_ENST00000395673_TTC17_chr11_43436140_ENST00000299240_length(amino acids)=698AA_BP=429
MIPPRGMSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIE
SSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSD
YYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIP
VYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVL
RGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALKNISGA
LEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGNCHEKTLDNSHDKQKYFDNSQSLDAAEEEPSERGTEEDPVFSVENSG
RDSDALRLESTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGDCRSED
DEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVASPGPQGLLDWKTRKVP

--------------------------------------------------------------
>28027_28027_7_EXT2-TTC17_EXT2_chr11_44151688_ENST00000533608_TTC17_chr11_43436140_ENST00000039989_length(transcript)=3898nt_BP=1507nt
CTGTCTGAGCATTTCACTGCGGAGCCTGAGCGCGCCTGCCTGGGAAAACACTGCAGCGGTGCTCGGACTCCTCCTGTCCAGCAGGAGGCG
CGGCCCGGCAGCTCCCGCATGCGCAGTGCGCTCGGTGTCAGACGGCCCGGATCCCGGTTACCGGCCCCTCGCTCGCTGCTCGCCAGCCCA
GACTCGGCCCTGGCAGTGGCGGCTGGCGATTCGGACCGATCCGACCTGGGCGGAGGTGGCCCGCGCCCCGCGGCATGAGCCGGTGACCAA
GCTCGGGGCCGAGCGGGAGGCAGCCGTGGCCGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATAT
CCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTGC
CACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTGT
TAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCAA
CCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGGA
GTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATGT
GCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGTT
CAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTAC
GTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTCC
ACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGTC
AGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACCC
ACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCTG
TGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAAA
GATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTTTTTGAGCCTGGG
AAATGCTTACCTTGCTCTGAAGAATATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATGTCCAGAGTGTGA
AAACAGCCTGAAGTTGATCCGCTGTATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTACGGTGGTTGAGGA
GAGCAATGGTTCTGATGAGATGGAGAATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGCATG
GCCTTTGGAAGGCTTTGGGGGTGCACTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCAGGA
TGGAGTGGCCAGAAGCTCTTGCTATGGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGTAAA
GAAACCCAAAGGAGATCATAAGAAAACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCTAGA
GATCACTGGCCCCAAGGTGGCATCTCCTGGGCCACAAGGAAAAAAACGTGACTACCAGCGTCTGGGATGGCCCAGCCCGGACGAATGCCT
CAAACTCCGCTGGGTAGAGCTGACTGCCATCGTGAGTACCTGGCTTGCAGTTTCTTCAAAAAACATTGACATCACAGAACACATAGATTT
TGCCACCCCTATACAGCAGCCAGCAATGGAGCCTCTTTGCAATGGCAATCTCCCCACGAGTATGCATACCCTGGACCACTTGCATGGGGT
TTCCAACCGAGCCAGCCTGCACTACACAGGGGAGAGTCAGTTAACAGAGGTATTACAAAATCTCGGCAAAGACCAATATCCACAACAGTC
GCTTGAACAGATTGGCACCCGAATTGCCAAAGTTTTGGAAAAGAACCAGACGTCCTGGGTCCTCTCCAGCATGGCAGCCCTCTACTGGAG
GGTGAAAGGCCAAGGAAAGAAGGCAATCGACTGCCTCCGCCAGGCTCTGCACTATGCGCCACACCAGATGAAGGATGTGCCCCTGATTAG
CCTGGCCAACATCTTGCACAATGCCAAGCTCTGGAATGACGCCGTCATAGTAGCCACCATGGCAGTAGAGATCGCACCACACTTTGCTGT
GAACCACTTCACTCTGGGCAATGTCTACGTGGCAATGGAAGAATTTGAAAAAGCACTGGTGTGGTATGAATCCACATTGAAGCTTCAGCC
CGAGTTTGTCCCAGCCAAGAACCGAATCCAGACCATCCAGTGTCACTTAATGCTGAAGAAGGGACGGCGCTCTCCTTAGTGCACTTCTTC
CTTCTCTCTTTCTCTTTACTCATGCTCTAAAAAAAAAGAATAAGAAAAGAAACCAATCATTGTCAGTATCTACTATTAATGATGTGTGTG
AAAATAACTAAGACTTATAACAGGACTTTTACATATGTGGGAATTGGTTTGTTTTTGTTTTTACGTTTCTCCTTTCCCCCAACCAACCTC
AGAAGAGGCACCTTCAGAAACACACATTTCTTAAAAGGAAAGTGCAGCTTCAAGATATTGTGTAAATACTGAGCCAAGACATTTCTGGAG
CTGTGCTCTGTCTCCAAAAACCTCAATGCCTTTAGGGCTTTTCTCAGTGGTCCAGCTAGCCTTCTCTTTGGAGGAGGATGAAGCCGCATT
GCACATTCTCTGCTTCCTGTCGTAGCCTCTGTTGTCAATGGAAATGCGGAAGCCCATCTGGTGCCCGTCAGTGAGAAGCAACGTTCTGCG
CTCTCTCCGTTAGACCTCCATGCTGTCCCCAGTCTTGTCCATTCCATGCTGCTGTGTTACAAACTCTCAGAGGTAGTTTGCAGGGGAGGA
AGGGGAATATGATTTTAAAAACAAAATATTTACAACAACAAAAATTCTTAGGATCACCTGACCTTTGTAATGTTATTTATGTTGGGGAGG
GAGGGGGGCTGAGAAGGGGAAATCAGCAGTGTGCAACATCTTTATAATTTGTACTTTAATTACAAATCACAAGGAAACCAATAAGTTGAA
ATCCTATATAACAGGTTTATATATATAGAATATGTATATTTGAAGCCCTCTACAGACTGAGTCTATGTTTTACTAATTCTTTGTTCACTG
TGTTACCCATCTTGGAATAAGTTGTGAATGTCAGCTCCCTCTCTCTGAGGCCTCCAGACTTAGCTCCTCAGGAGGGTAATGAGCCAAGGT
TGAGTGTTTCCATACAATGCTTTTACCTTTGATCCCAGGAGAATCAGAAACTCCAACATTTTGGAATCTTCAAGGGCACATACTGAGAAA
AAAAATAAAATTGTTTATGAGCAAAATA

>28027_28027_7_EXT2-TTC17_EXT2_chr11_44151688_ENST00000533608_TTC17_chr11_43436140_ENST00000039989_length(amino acids)=954AA_BP=500
MSISLRSLSAPAWENTAAVLGLLLSSRRRGPAAPACAVRSVSDGPDPGYRPLARCSPAQTRPWQWRLAIRTDPTWAEVARAPRHEPVTKL
GAEREAAVAEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVR
LPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACLFVPSIDVL
NQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPR
QYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLSDVLQAGCV
PVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECEN
SLKLIRCMQFYPFLYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDG
VARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVASPGPQGKKRDYQRLGWPSPDECLK
LRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSL
EQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVN
HFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRSP

--------------------------------------------------------------
>28027_28027_8_EXT2-TTC17_EXT2_chr11_44151688_ENST00000533608_TTC17_chr11_43436140_ENST00000299240_length(transcript)=3068nt_BP=1507nt
CTGTCTGAGCATTTCACTGCGGAGCCTGAGCGCGCCTGCCTGGGAAAACACTGCAGCGGTGCTCGGACTCCTCCTGTCCAGCAGGAGGCG
CGGCCCGGCAGCTCCCGCATGCGCAGTGCGCTCGGTGTCAGACGGCCCGGATCCCGGTTACCGGCCCCTCGCTCGCTGCTCGCCAGCCCA
GACTCGGCCCTGGCAGTGGCGGCTGGCGATTCGGACCGATCCGACCTGGGCGGAGGTGGCCCGCGCCCCGCGGCATGAGCCGGTGACCAA
GCTCGGGGCCGAGCGGGAGGCAGCCGTGGCCGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATAT
CCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTGC
CACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTGT
TAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCAA
CCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGGA
GTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATGT
GCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGTT
CAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTAC
GTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTCC
ACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGTC
AGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACCC
ACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCTG
TGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAAA
GATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTTTTTGAGCCTGGG
AAATGCTTACCTTGCTCTGAAGAATATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATGTCCAGAGTGTGA
AAACAGCCTGAAGTTGATCCGCTGTATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTAATTGTCATGAGAA
AACCCTGGACAACAGCCATGACAAACAGAAATATTTTGACAACTCACAGTCACTGGATGCTGCTGAAGAAGAGCCCTCTGAGAGAGGAAC
AGAGGAGGACCCTGTATTCTCTGTTGAGAATTCAGGGAGGGACTCAGATGCCCTTAGACTTGAAAGTACGGTGGTTGAGGAGAGCAATGG
TTCTGATGAGATGGAGAATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGCATGGCCTTTGGA
AGGCTTTGGGGGTGCACTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCAGGATGGAGTGGC
CAGAAGCTCTTGCTATGGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGTAAAGAAACCCAA
AGGAGATCATAAGAAAACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCTAGAGATCACTGG
CCCCAAGGTGGCATCTCCTGGGCCACAAGGGCTACTAGACTGGAAGACCAGGAAAGTGCCATAGACATAATGTAACTGGATTTCAGCAAG
GCATTTAACAGAGCCTCTTATGATATCCTTGTGAACCAGATGGAGAGATGTGGGCTTGAAGCCTTCCCATTGCCTACAGGATAAAATTCA
AACTTCCTAGTGTGGTGTACAAGACCCTTTACAGCCCGCCTCTGTGTACCCTTCAACACCATTCTCTGAACCAACCATGCTCATGTTTTT
ACCTCAGTGCCTTTGCACATGCTATTCCCTCTGCCTGGAATGCCCTGTGCCCCCTCTGCCCTCTGCCGTGCTAAAATATCACTCATCCTT
AAACTTCAAAATCAAGTGCCATCTCTTCCTTGTTACCTTCAGGCAGAATTAGTTACTCTTTCCTCTGTGCAATTGTTCTATATCTTCGCT
CTAGCTCTTTTCCTGTTGTATTGTAATGATTTGTTTATGTTTACCTTCCTTACTAGACTGTGAGCTCAAGAGCAGGCCGTCTTAATTATT
CCTTTCTGTACCCCTAGTGTCTTTTATGGTTCTCAGCCCCTTATAACAGGTGCTCAATAAATATTTTTCAAATGAAATTATTAAATGTAA
AAGAAAATTAAGATTTTTTGTGAAAATTATGGCTTATTTAAGTTATTAATTTAAACAGAGTTAATTTGAAACTCTTCCAAAACTGTTCCT
TTCTGTTTTGTTAAAATCTCAATCTAAACCCCTGCCTGTACCTCAAACAGTTTTCTACTGTTCGTAAATTCCTATAATATAAAAAGCGCT
ATACAGAA

>28027_28027_8_EXT2-TTC17_EXT2_chr11_44151688_ENST00000533608_TTC17_chr11_43436140_ENST00000299240_length(amino acids)=769AA_BP=500
MSISLRSLSAPAWENTAAVLGLLLSSRRRGPAAPACAVRSVSDGPDPGYRPLARCSPAQTRPWQWRLAIRTDPTWAEVARAPRHEPVTKL
GAEREAAVAEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVR
LPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACLFVPSIDVL
NQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPR
QYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLSDVLQAGCV
PVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECEN
SLKLIRCMQFYPFLYNITSSVCSGNCHEKTLDNSHDKQKYFDNSQSLDAAEEEPSERGTEEDPVFSVENSGRDSDALRLESTVVEESNGS
DEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGDCRSEDDEATEWITFQVKRVKKPKG
DHKKTPGKKVETGQIENGHRYQANLEITGPKVASPGPQGLLDWKTRKVP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for EXT2-TTC17

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for EXT2-TTC17

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for EXT2-TTC17

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	EXT2	C1851413	EXOSTOSES, MULTIPLE, TYPE II	18	CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	EXT2	C4225248	SEIZURES, SCOLIOSIS, AND MACROCEPHALY SYNDROME	4	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	EXT2	C0015306	Hereditary Multiple Exostoses	1	CTD_human
Hgene	EXT2	C1832588	Chromosome 11p11.2 Deletion Syndrome	1	ORPHANET

Fusion Gene Studies in Kim Lab

Fusion gene:EXT2-TTC17 (FusionGDB2 ID:HG2132TG55761)

Fusion Gene Summary for EXT2-TTC17

Fusion Gene ORF analysis for EXT2-TTC17

Fusion Genomic Features for EXT2-TTC17

Fusion Protein Features for EXT2-TTC17

Fusion Gene Sequence for EXT2-TTC17

Fusion Gene PPI Analysis for EXT2-TTC17

Related Drugs for EXT2-TTC17

Related Diseases for EXT2-TTC17

Fusion Gene Studies
in Kim Lab