Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ALCAM-PARN (FusionGDB2 ID:HG214TG5073)

Fusion Gene Summary for ALCAM-PARN

check button Fusion gene summary
Fusion gene informationFusion gene name: ALCAM-PARN
Fusion gene ID: hg214tg5073
HgeneTgene
Gene symbol

ALCAM

PARN

Gene ID

214

5073

Gene nameactivated leukocyte cell adhesion moleculepoly(A)-specific ribonuclease
SynonymsCD166|MEMDDAN|DKCB6|PFBMFT4
Cytomap('ALCAM')('PARN')

3q13.11

16p13.12

Type of geneprotein-codingprotein-coding
DescriptionCD166 antigenpoly(A)-specific ribonuclease PARNdeadenylating nucleasedeadenylation nucleasepolyadenylate-specific ribonuclease
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000306107, ENST00000472644, 
ENST00000389927, ENST00000481337, 
ENST00000486979, 
Fusion gene scores* DoF score15 X 13 X 6=11709 X 8 X 4=288
# samples 179
** MAII scorelog2(17/1170*10)=-2.78290187833307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALCAM [Title/Abstract] AND PARN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALCAM(105086325)-PARN(14576684), # samples:2
Anticipated loss of major functional domain due to fusion event.ALCAM-PARN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALCAM-PARN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePARN

GO:0000495

box H/ACA snoRNA 3'-end processing

22442037

TgenePARN

GO:0010587

miRNA catabolic process

25049417

TgenePARN

GO:0071051

polyadenylation-dependent snoRNA 3'-end processing

22442037


check buttonFusion gene breakpoints across ALCAM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PARN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A4MIALCAMchr3

105086325

+PARNchr16

14576684

-
ChimerDB4UCECTCGA-B5-A11NALCAMchr3

105086325

+PARNchr16

14576684

-


Top

Fusion Gene ORF analysis for ALCAM-PARN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000306107ENST00000566021ALCAMchr3

105086325

+PARNchr16

14576684

-
5CDS-intronENST00000472644ENST00000566021ALCAMchr3

105086325

+PARNchr16

14576684

-
In-frameENST00000306107ENST00000341484ALCAMchr3

105086325

+PARNchr16

14576684

-
In-frameENST00000306107ENST00000420015ALCAMchr3

105086325

+PARNchr16

14576684

-
In-frameENST00000306107ENST00000437198ALCAMchr3

105086325

+PARNchr16

14576684

-
In-frameENST00000306107ENST00000539279ALCAMchr3

105086325

+PARNchr16

14576684

-
In-frameENST00000472644ENST00000341484ALCAMchr3

105086325

+PARNchr16

14576684

-
In-frameENST00000472644ENST00000420015ALCAMchr3

105086325

+PARNchr16

14576684

-
In-frameENST00000472644ENST00000437198ALCAMchr3

105086325

+PARNchr16

14576684

-
In-frameENST00000472644ENST00000539279ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-3CDSENST00000389927ENST00000341484ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-3CDSENST00000389927ENST00000420015ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-3CDSENST00000389927ENST00000437198ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-3CDSENST00000389927ENST00000539279ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-3CDSENST00000481337ENST00000341484ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-3CDSENST00000481337ENST00000420015ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-3CDSENST00000481337ENST00000437198ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-3CDSENST00000481337ENST00000539279ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-3CDSENST00000486979ENST00000341484ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-3CDSENST00000486979ENST00000420015ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-3CDSENST00000486979ENST00000437198ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-3CDSENST00000486979ENST00000539279ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-intronENST00000389927ENST00000566021ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-intronENST00000481337ENST00000566021ALCAMchr3

105086325

+PARNchr16

14576684

-
intron-intronENST00000486979ENST00000566021ALCAMchr3

105086325

+PARNchr16

14576684

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000306107ALCAMchr3105086325+ENST00000437198PARNchr1614576684-20295733921012206
ENST00000306107ALCAMchr3105086325+ENST00000420015PARNchr1614576684-14575733921012206
ENST00000306107ALCAMchr3105086325+ENST00000341484PARNchr1614576684-11255733921012206
ENST00000306107ALCAMchr3105086325+ENST00000539279PARNchr1614576684-10625733921012206
ENST00000472644ALCAMchr3105086325+ENST00000437198PARNchr1614576684-159513966578170
ENST00000472644ALCAMchr3105086325+ENST00000420015PARNchr1614576684-102313966578170
ENST00000472644ALCAMchr3105086325+ENST00000341484PARNchr1614576684-69113966578170
ENST00000472644ALCAMchr3105086325+ENST00000539279PARNchr1614576684-62813966578170

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000306107ENST00000437198ALCAMchr3105086325+PARNchr1614576684-0.0070575570.99294245
ENST00000306107ENST00000420015ALCAMchr3105086325+PARNchr1614576684-0.0096310190.990369
ENST00000306107ENST00000341484ALCAMchr3105086325+PARNchr1614576684-0.0143339710.985666
ENST00000306107ENST00000539279ALCAMchr3105086325+PARNchr1614576684-0.0152238540.98477614
ENST00000472644ENST00000437198ALCAMchr3105086325+PARNchr1614576684-0.0042124670.99578756
ENST00000472644ENST00000420015ALCAMchr3105086325+PARNchr1614576684-0.0086279990.991372
ENST00000472644ENST00000341484ALCAMchr3105086325+PARNchr1614576684-0.0116545550.9883455
ENST00000472644ENST00000539279ALCAMchr3105086325+PARNchr1614576684-0.0128410490.9871589

Top

Fusion Genomic Features for ALCAM-PARN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for ALCAM-PARN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:105086325/chr16:14576684)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALCAMchr3:105086325chr16:14576684ENST00000306107+116125_234241201.0DomainNote=Ig-like V-type 2
HgeneALCAMchr3:105086325chr16:14576684ENST00000306107+116245_328241201.0DomainNote=Ig-like C2-type 1
HgeneALCAMchr3:105086325chr16:14576684ENST00000306107+11628_120241201.0DomainNote=Ig-like V-type 1
HgeneALCAMchr3:105086325chr16:14576684ENST00000306107+116333_409241201.0DomainNote=Ig-like C2-type 2
HgeneALCAMchr3:105086325chr16:14576684ENST00000306107+116416_501241201.0DomainNote=Ig-like C2-type 3
HgeneALCAMchr3:105086325chr16:14576684ENST00000472644+115125_234241319.6666666666667DomainNote=Ig-like V-type 2
HgeneALCAMchr3:105086325chr16:14576684ENST00000472644+115245_328241319.6666666666667DomainNote=Ig-like C2-type 1
HgeneALCAMchr3:105086325chr16:14576684ENST00000472644+11528_120241319.6666666666667DomainNote=Ig-like V-type 1
HgeneALCAMchr3:105086325chr16:14576684ENST00000472644+115333_409241319.6666666666667DomainNote=Ig-like C2-type 2
HgeneALCAMchr3:105086325chr16:14576684ENST00000472644+115416_501241319.6666666666667DomainNote=Ig-like C2-type 3
HgeneALCAMchr3:105086325chr16:14576684ENST00000306107+11628_527241201.0Topological domainExtracellular
HgeneALCAMchr3:105086325chr16:14576684ENST00000306107+116550_583241201.0Topological domainCytoplasmic
HgeneALCAMchr3:105086325chr16:14576684ENST00000472644+11528_527241319.6666666666667Topological domainExtracellular
HgeneALCAMchr3:105086325chr16:14576684ENST00000472644+115550_583241319.6666666666667Topological domainCytoplasmic
HgeneALCAMchr3:105086325chr16:14576684ENST00000306107+116528_549241201.0TransmembraneHelical
HgeneALCAMchr3:105086325chr16:14576684ENST00000472644+115528_549241319.6666666666667TransmembraneHelical
TgenePARNchr3:105086325chr16:14576684ENST000003414842024178_245432579.0DomainR3H
TgenePARNchr3:105086325chr16:14576684ENST000004200151923178_245447594.0DomainR3H
TgenePARNchr3:105086325chr16:14576684ENST000004371982024178_245493640.0DomainR3H


Top

Fusion Gene Sequence for ALCAM-PARN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3818_3818_1_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000306107_PARN_chr16_14576684_ENST00000341484_length(transcript)=1125nt_BP=573nt
AGAGCAGCCCGGAGACCGCTGCCGCCGCTGCCGCTGCTACCACCGCTGCCACCTGAGGAGACCCGCCGCCCCCCCGTCGCCGCCTCCTGC
GAGTCCTTCTTAGCACCTGGCGTTTCATGCACATTGCCACTGCCATTATTATTATCATTCCAATACAAGGAAAATAAAAGAAGATACCAG
CGAAAAGAACCGCTTACACCTTTCCGAATTACTCAAGTGTCTCCTGGAAACAGAGGGTCGTTGTCCCCGGAGGAGCAGCCGAAGGGCCCG
TGGGCTGGTGTTGACCGGGAGGGAGGAGGAGTTGGGGGCATTGCGTGGTGGAAAGTTGCGTGCGGCAGAGAACCGAAGGTGCAGCGCCAC
AGCCCAGGGGACGGTGTGTCTGGGAGAAGACGCTGCCCCTGCGTCGGGACCCGCCAGCGCGCGGGCACCGCGGGGCCCGGGACGACGCCC
CCTCCTGCGGCGTGGACTCCGTCAGTGGCCCACCAAGAAGGAGGAGGAATATGGAATCCAAGGGGGCCAGTTCCTGCCGTCTGCTCTTCT
GCCTCTTGATCTCCGCCACCGTCTTCAGGCCAGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAAACCTATGCTGAATATA
TGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAACGGTTAAACCCCCAGT
GCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGAAATTTGAGTCCTAGTC
AAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGTGCAGAGCCCCTCTCAG
AGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAACAGCCCTGCCACACTCT
TTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAGCCGGCTGGCACATTTGGA
AGCCGCACTGTATTTAACTTAATCAAATGTGGTATGGGAGGGGTT

>3818_3818_1_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000306107_PARN_chr16_14576684_ENST00000341484_length(amino acids)=206AA_BP=60
MPLRRDPPARGHRGARDDAPSCGVDSVSGPPRRRRNMESKGASSCRLLFCLLISATVFRPAVNTSKYAESYRIQTYAEYMGRKQEEKQIK
RKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKR
MKKELSPAGSISKNSPATLFEVPDTW

--------------------------------------------------------------
>3818_3818_2_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000306107_PARN_chr16_14576684_ENST00000420015_length(transcript)=1457nt_BP=573nt
AGAGCAGCCCGGAGACCGCTGCCGCCGCTGCCGCTGCTACCACCGCTGCCACCTGAGGAGACCCGCCGCCCCCCCGTCGCCGCCTCCTGC
GAGTCCTTCTTAGCACCTGGCGTTTCATGCACATTGCCACTGCCATTATTATTATCATTCCAATACAAGGAAAATAAAAGAAGATACCAG
CGAAAAGAACCGCTTACACCTTTCCGAATTACTCAAGTGTCTCCTGGAAACAGAGGGTCGTTGTCCCCGGAGGAGCAGCCGAAGGGCCCG
TGGGCTGGTGTTGACCGGGAGGGAGGAGGAGTTGGGGGCATTGCGTGGTGGAAAGTTGCGTGCGGCAGAGAACCGAAGGTGCAGCGCCAC
AGCCCAGGGGACGGTGTGTCTGGGAGAAGACGCTGCCCCTGCGTCGGGACCCGCCAGCGCGCGGGCACCGCGGGGCCCGGGACGACGCCC
CCTCCTGCGGCGTGGACTCCGTCAGTGGCCCACCAAGAAGGAGGAGGAATATGGAATCCAAGGGGGCCAGTTCCTGCCGTCTGCTCTTCT
GCCTCTTGATCTCCGCCACCGTCTTCAGGCCAGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAAACCTATGCTGAATATA
TGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAACGGTTAAACCCCCAGT
GCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGAAATTTGAGTCCTAGTC
AAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGTGCAGAGCCCCTCTCAG
AGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAACAGCCCTGCCACACTCT
TTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAGCCGGCTGGCACATTTGGA
AGCCGCACTGTATTTAACTTAATCAAATGTGGTATGGGAGGGGTTGGAAACCAAGTTGTCTCCTGGGGGGGAGAAAACAGGTTTTATTTT
TGTGGCTGTGGTTTTTTCCCCTTTTTAATCTAACTGCCTGTTGACATTGACACTCATCACGGTTGTAGGCTGTCATGAATGTGTACGTGC
TTAACCAGTGAATTCCGTGTTGCTCTTGTGAGGCCTTTCCTGTCATGACCCAGTGTGCTTAAGAACCTGCCTGATGGGGAGTGTCGGCTG
TGAAATCTGCAAAAAGAGCTGACATTCCAGCTGCTGTGATCATGAATTTGGGGGTGTACTGTCCTGCCTGTGCATCTTCTCGCACTGAGA
TTTTGAGGCAGTTGCAG

>3818_3818_2_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000306107_PARN_chr16_14576684_ENST00000420015_length(amino acids)=206AA_BP=60
MPLRRDPPARGHRGARDDAPSCGVDSVSGPPRRRRNMESKGASSCRLLFCLLISATVFRPAVNTSKYAESYRIQTYAEYMGRKQEEKQIK
RKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKR
MKKELSPAGSISKNSPATLFEVPDTW

--------------------------------------------------------------
>3818_3818_3_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000306107_PARN_chr16_14576684_ENST00000437198_length(transcript)=2029nt_BP=573nt
AGAGCAGCCCGGAGACCGCTGCCGCCGCTGCCGCTGCTACCACCGCTGCCACCTGAGGAGACCCGCCGCCCCCCCGTCGCCGCCTCCTGC
GAGTCCTTCTTAGCACCTGGCGTTTCATGCACATTGCCACTGCCATTATTATTATCATTCCAATACAAGGAAAATAAAAGAAGATACCAG
CGAAAAGAACCGCTTACACCTTTCCGAATTACTCAAGTGTCTCCTGGAAACAGAGGGTCGTTGTCCCCGGAGGAGCAGCCGAAGGGCCCG
TGGGCTGGTGTTGACCGGGAGGGAGGAGGAGTTGGGGGCATTGCGTGGTGGAAAGTTGCGTGCGGCAGAGAACCGAAGGTGCAGCGCCAC
AGCCCAGGGGACGGTGTGTCTGGGAGAAGACGCTGCCCCTGCGTCGGGACCCGCCAGCGCGCGGGCACCGCGGGGCCCGGGACGACGCCC
CCTCCTGCGGCGTGGACTCCGTCAGTGGCCCACCAAGAAGGAGGAGGAATATGGAATCCAAGGGGGCCAGTTCCTGCCGTCTGCTCTTCT
GCCTCTTGATCTCCGCCACCGTCTTCAGGCCAGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAAACCTATGCTGAATATA
TGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAACGGTTAAACCCCCAGT
GCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGAAATTTGAGTCCTAGTC
AAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGTGCAGAGCCCCTCTCAG
AGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAACAGCCCTGCCACACTCT
TTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAGCCGGCTGGCACATTTGGA
AGCCGCACTGTATTTAACTTAATCAAATGTGGTATGGGAGGGGTTGGAAACCAAGTTGTCTCCTGGGGGGGAGAAAACAGGTTTTATTTT
TGTGGCTGTGGTTTTTTCCCCTTTTTAATCTAACTGCCTGTTGACATTGACACTCATCACGGTTGTAGGCTGTCATGAATGTGTACGTGC
TTAACCAGTGAATTCCGTGTTGCTCTTGTGAGGCCTTTCCTGTCATGACCCAGTGTGCTTAAGAACCTGCCTGATGGGGAGTGTCGGCTG
TGAAATCTGCAAAAAGAGCTGACATTCCAGCTGCTGTGATCATGAATTTGGGGGTGTACTGTCCTGCCTGTGCATCTTCTCGCACTGAGA
TTTTGAGGCAGTTGCAGCCCTCGGTTAGTCTCCCAGTGGAAAAATCGGTTGTGCCTCCCTGCTTCCCACCATAGCTGCCTGAAAACATGA
CGCTCTCAAGCTTGTCCTTCCTTCAGGAAGATGTCCACTCATGCCCACCCATGAGAGGGCTTGCCGTATGCCCTGGCCTTTGGGCATATT
TATGTAGAGTTCCTTTCTCCTAAGACGTGAGTTTCTCATGGGGGATGTACGAGTAAAAAGGTTAACTTCTGTTCTTATGCGTGGCGCTGT
GTTCACTTTCCAGAGTCTCTGTTCGTTTGTTTGGATGGCGGTCTCGGGGTACGGCAGCGTGTGTGCGTACGTGTCTGTGTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAATCGTGCAAATCTACAACATGTCCCAGCCCATTCTCCGTTGAAACAGATCACAGC
AACGACAAACGCTCATGGCGCTGCTTTGCTCCACCCGCTTCAGATAGATCATTGTTAGATATTTCACATTTTTGTATGGTGGAAATAAAA
ATGAAAAATGTATTTCCAAAAGATGAAAATTAAAAACATTTTCATAGGA

>3818_3818_3_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000306107_PARN_chr16_14576684_ENST00000437198_length(amino acids)=206AA_BP=60
MPLRRDPPARGHRGARDDAPSCGVDSVSGPPRRRRNMESKGASSCRLLFCLLISATVFRPAVNTSKYAESYRIQTYAEYMGRKQEEKQIK
RKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKR
MKKELSPAGSISKNSPATLFEVPDTW

--------------------------------------------------------------
>3818_3818_4_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000306107_PARN_chr16_14576684_ENST00000539279_length(transcript)=1062nt_BP=573nt
AGAGCAGCCCGGAGACCGCTGCCGCCGCTGCCGCTGCTACCACCGCTGCCACCTGAGGAGACCCGCCGCCCCCCCGTCGCCGCCTCCTGC
GAGTCCTTCTTAGCACCTGGCGTTTCATGCACATTGCCACTGCCATTATTATTATCATTCCAATACAAGGAAAATAAAAGAAGATACCAG
CGAAAAGAACCGCTTACACCTTTCCGAATTACTCAAGTGTCTCCTGGAAACAGAGGGTCGTTGTCCCCGGAGGAGCAGCCGAAGGGCCCG
TGGGCTGGTGTTGACCGGGAGGGAGGAGGAGTTGGGGGCATTGCGTGGTGGAAAGTTGCGTGCGGCAGAGAACCGAAGGTGCAGCGCCAC
AGCCCAGGGGACGGTGTGTCTGGGAGAAGACGCTGCCCCTGCGTCGGGACCCGCCAGCGCGCGGGCACCGCGGGGCCCGGGACGACGCCC
CCTCCTGCGGCGTGGACTCCGTCAGTGGCCCACCAAGAAGGAGGAGGAATATGGAATCCAAGGGGGCCAGTTCCTGCCGTCTGCTCTTCT
GCCTCTTGATCTCCGCCACCGTCTTCAGGCCAGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAAACCTATGCTGAATATA
TGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAACGGTTAAACCCCCAGT
GCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGAAATTTGAGTCCTAGTC
AAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGTGCAGAGCCCCTCTCAG
AGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAACAGCCCTGCCACACTCT
TTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAG

>3818_3818_4_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000306107_PARN_chr16_14576684_ENST00000539279_length(amino acids)=206AA_BP=60
MPLRRDPPARGHRGARDDAPSCGVDSVSGPPRRRRNMESKGASSCRLLFCLLISATVFRPAVNTSKYAESYRIQTYAEYMGRKQEEKQIK
RKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKR
MKKELSPAGSISKNSPATLFEVPDTW

--------------------------------------------------------------
>3818_3818_5_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000472644_PARN_chr16_14576684_ENST00000341484_length(transcript)=691nt_BP=139nt
GCCCGGGACGACGCCCCCTCCTGCGGCGTGGACTCCGTCAGTGGCCCACCAAGAAGGAGGAGGAATATGGAATCCAAGGGGGCCAGTTCC
TGCCGTCTGCTCTTCTGCCTCTTGATCTCCGCCACCGTCTTCAGGCCAGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAA
ACCTATGCTGAATATATGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAA
CGGTTAAACCCCCAGTGCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGA
AATTTGAGTCCTAGTCAAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGT
GCAGAGCCCCTCTCAGAGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAAC
AGCCCTGCCACACTCTTTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAGCC
GGCTGGCACATTTGGAAGCCGCACTGTATTTAACTTAATCAAATGTGGTATGGGAGGGGTT

>3818_3818_5_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000472644_PARN_chr16_14576684_ENST00000341484_length(amino acids)=170AA_BP=24
MESKGASSCRLLFCLLISATVFRPAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFT
APSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW

--------------------------------------------------------------
>3818_3818_6_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000472644_PARN_chr16_14576684_ENST00000420015_length(transcript)=1023nt_BP=139nt
GCCCGGGACGACGCCCCCTCCTGCGGCGTGGACTCCGTCAGTGGCCCACCAAGAAGGAGGAGGAATATGGAATCCAAGGGGGCCAGTTCC
TGCCGTCTGCTCTTCTGCCTCTTGATCTCCGCCACCGTCTTCAGGCCAGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAA
ACCTATGCTGAATATATGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAA
CGGTTAAACCCCCAGTGCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGA
AATTTGAGTCCTAGTCAAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGT
GCAGAGCCCCTCTCAGAGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAAC
AGCCCTGCCACACTCTTTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAGCC
GGCTGGCACATTTGGAAGCCGCACTGTATTTAACTTAATCAAATGTGGTATGGGAGGGGTTGGAAACCAAGTTGTCTCCTGGGGGGGAGA
AAACAGGTTTTATTTTTGTGGCTGTGGTTTTTTCCCCTTTTTAATCTAACTGCCTGTTGACATTGACACTCATCACGGTTGTAGGCTGTC
ATGAATGTGTACGTGCTTAACCAGTGAATTCCGTGTTGCTCTTGTGAGGCCTTTCCTGTCATGACCCAGTGTGCTTAAGAACCTGCCTGA
TGGGGAGTGTCGGCTGTGAAATCTGCAAAAAGAGCTGACATTCCAGCTGCTGTGATCATGAATTTGGGGGTGTACTGTCCTGCCTGTGCA
TCTTCTCGCACTGAGATTTTGAGGCAGTTGCAG

>3818_3818_6_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000472644_PARN_chr16_14576684_ENST00000420015_length(amino acids)=170AA_BP=24
MESKGASSCRLLFCLLISATVFRPAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFT
APSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW

--------------------------------------------------------------
>3818_3818_7_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000472644_PARN_chr16_14576684_ENST00000437198_length(transcript)=1595nt_BP=139nt
GCCCGGGACGACGCCCCCTCCTGCGGCGTGGACTCCGTCAGTGGCCCACCAAGAAGGAGGAGGAATATGGAATCCAAGGGGGCCAGTTCC
TGCCGTCTGCTCTTCTGCCTCTTGATCTCCGCCACCGTCTTCAGGCCAGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAA
ACCTATGCTGAATATATGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAA
CGGTTAAACCCCCAGTGCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGA
AATTTGAGTCCTAGTCAAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGT
GCAGAGCCCCTCTCAGAGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAAC
AGCCCTGCCACACTCTTTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAGCC
GGCTGGCACATTTGGAAGCCGCACTGTATTTAACTTAATCAAATGTGGTATGGGAGGGGTTGGAAACCAAGTTGTCTCCTGGGGGGGAGA
AAACAGGTTTTATTTTTGTGGCTGTGGTTTTTTCCCCTTTTTAATCTAACTGCCTGTTGACATTGACACTCATCACGGTTGTAGGCTGTC
ATGAATGTGTACGTGCTTAACCAGTGAATTCCGTGTTGCTCTTGTGAGGCCTTTCCTGTCATGACCCAGTGTGCTTAAGAACCTGCCTGA
TGGGGAGTGTCGGCTGTGAAATCTGCAAAAAGAGCTGACATTCCAGCTGCTGTGATCATGAATTTGGGGGTGTACTGTCCTGCCTGTGCA
TCTTCTCGCACTGAGATTTTGAGGCAGTTGCAGCCCTCGGTTAGTCTCCCAGTGGAAAAATCGGTTGTGCCTCCCTGCTTCCCACCATAG
CTGCCTGAAAACATGACGCTCTCAAGCTTGTCCTTCCTTCAGGAAGATGTCCACTCATGCCCACCCATGAGAGGGCTTGCCGTATGCCCT
GGCCTTTGGGCATATTTATGTAGAGTTCCTTTCTCCTAAGACGTGAGTTTCTCATGGGGGATGTACGAGTAAAAAGGTTAACTTCTGTTC
TTATGCGTGGCGCTGTGTTCACTTTCCAGAGTCTCTGTTCGTTTGTTTGGATGGCGGTCTCGGGGTACGGCAGCGTGTGTGCGTACGTGT
CTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAATCGTGCAAATCTACAACATGTCCCAGCCCATTCTCCGT
TGAAACAGATCACAGCAACGACAAACGCTCATGGCGCTGCTTTGCTCCACCCGCTTCAGATAGATCATTGTTAGATATTTCACATTTTTG
TATGGTGGAAATAAAAATGAAAAATGTATTTCCAAAAGATGAAAATTAAAAACATTTTCATAGGA

>3818_3818_7_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000472644_PARN_chr16_14576684_ENST00000437198_length(amino acids)=170AA_BP=24
MESKGASSCRLLFCLLISATVFRPAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFT
APSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW

--------------------------------------------------------------
>3818_3818_8_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000472644_PARN_chr16_14576684_ENST00000539279_length(transcript)=628nt_BP=139nt
GCCCGGGACGACGCCCCCTCCTGCGGCGTGGACTCCGTCAGTGGCCCACCAAGAAGGAGGAGGAATATGGAATCCAAGGGGGCCAGTTCC
TGCCGTCTGCTCTTCTGCCTCTTGATCTCCGCCACCGTCTTCAGGCCAGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAA
ACCTATGCTGAATATATGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAA
CGGTTAAACCCCCAGTGCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGA
AATTTGAGTCCTAGTCAAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGT
GCAGAGCCCCTCTCAGAGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAAC
AGCCCTGCCACACTCTTTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAG

>3818_3818_8_ALCAM-PARN_ALCAM_chr3_105086325_ENST00000472644_PARN_chr16_14576684_ENST00000539279_length(amino acids)=170AA_BP=24
MESKGASSCRLLFCLLISATVFRPAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFT
APSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ALCAM-PARN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ALCAM-PARN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ALCAM-PARN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALCAMC0007097Carcinoma1CTD_human
HgeneALCAMC0024667Animal Mammary Neoplasms1CTD_human
HgeneALCAMC0024668Mammary Neoplasms, Experimental1CTD_human
HgeneALCAMC0205696Anaplastic carcinoma1CTD_human
HgeneALCAMC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneALCAMC0205698Undifferentiated carcinoma1CTD_human
HgeneALCAMC0205699Carcinomatosis1CTD_human
HgeneALCAMC1257925Mammary Carcinoma, Animal1CTD_human
TgeneC4225347PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 44CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC4225356DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 63CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0265965Dyskeratosis Congenita2GENOMICS_ENGLAND;ORPHANET
TgeneC0085786Hamman-Rich syndrome1ORPHANET
TgeneC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET
TgeneC1846142HOYERAAL-HREIDARSSON SYNDROME1ORPHANET
TgeneC4721508Hamman-Rich Disease1CTD_human
TgeneC4721509Usual Interstitial Pneumonia1CTD_human
TgeneC4721952Familial Idiopathic Pulmonary Fibrosis1CTD_human