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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALDH2-LRBA (FusionGDB2 ID:HG217TG987)

Fusion Gene Summary for ALDH2-LRBA

check button Fusion gene summary
Fusion gene informationFusion gene name: ALDH2-LRBA
Fusion gene ID: hg217tg987
HgeneTgene
Gene symbol

ALDH2

LRBA

Gene ID

217

987

Gene namealdehyde dehydrogenase 2 family memberLPS responsive beige-like anchor protein
SynonymsALDH-E2|ALDHI|ALDMBGL|CDC4L|CVID8|LAB300|LBA
Cytomap('ALDH2')('LRBA')

12q24.12

4q31.3

Type of geneprotein-codingprotein-coding
Descriptionaldehyde dehydrogenase, mitochondrialALDH class 2acetaldehyde dehydrogenase 2aldehyde dehydrogenase 2 family (mitochondrial)epididymis secretory sperm binding proteinliver mitochondrial ALDHnucleus-encoded mitochondrial aldehyde dehydrogenase 2lipopolysaccharide-responsive and beige-like anchor proteinCDC4-like proteinLPS-responsive vesicle trafficking, beach and anchor containingvesicle trafficking, beach and anchor containing
Modification date2020031320200320
UniProtAcc

P05091

.
Ensembl transtripts involved in fusion geneENST00000261733, ENST00000416293, 
Fusion gene scores* DoF score26 X 20 X 11=572025 X 25 X 10=6250
# samples 2127
** MAII scorelog2(21/5720*10)=-4.76755391399963
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/6250*10)=-4.53282487738598
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALDH2 [Title/Abstract] AND LRBA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALDH2(112237867)-LRBA(151793907), # samples:3
Anticipated loss of major functional domain due to fusion event.ALDH2-LRBA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALDH2-LRBA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ALDH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LRBA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-A50Z-01AALDH2chr12

112237867

-LRBAchr4

151793907

-
ChimerDB4LUSCTCGA-85-A50Z-01AALDH2chr12

112237867

+LRBAchr4

151793907

-
ChimerDB4LUSCTCGA-85-A50ZALDH2chr12

112237867

+LRBAchr4

151793907

-


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Fusion Gene ORF analysis for ALDH2-LRBA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261733ENST00000357115ALDH2chr12

112237867

+LRBAchr4

151793907

-
5CDS-intronENST00000261733ENST00000503716ALDH2chr12

112237867

+LRBAchr4

151793907

-
5CDS-intronENST00000261733ENST00000507224ALDH2chr12

112237867

+LRBAchr4

151793907

-
5CDS-intronENST00000416293ENST00000357115ALDH2chr12

112237867

+LRBAchr4

151793907

-
5CDS-intronENST00000416293ENST00000503716ALDH2chr12

112237867

+LRBAchr4

151793907

-
5CDS-intronENST00000416293ENST00000507224ALDH2chr12

112237867

+LRBAchr4

151793907

-
In-frameENST00000261733ENST00000510413ALDH2chr12

112237867

+LRBAchr4

151793907

-
In-frameENST00000261733ENST00000535741ALDH2chr12

112237867

+LRBAchr4

151793907

-
In-frameENST00000416293ENST00000510413ALDH2chr12

112237867

+LRBAchr4

151793907

-
In-frameENST00000416293ENST00000535741ALDH2chr12

112237867

+LRBAchr4

151793907

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000416293ALDH2chr12112237867+ENST00000535741LRBAchr4151793907-903513619677542552
ENST00000416293ALDH2chr12112237867+ENST00000510413LRBAchr4151793907-894313619677512551
ENST00000261733ALDH2chr12112237867+ENST00000535741LRBAchr4151793907-914114676178602599
ENST00000261733ALDH2chr12112237867+ENST00000510413LRBAchr4151793907-904914676178572598

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000416293ENST00000535741ALDH2chr12112237867+LRBAchr4151793907-0.000762520.99923754
ENST00000416293ENST00000510413ALDH2chr12112237867+LRBAchr4151793907-0.0007614140.9992386
ENST00000261733ENST00000535741ALDH2chr12112237867+LRBAchr4151793907-0.000751120.9992488
ENST00000261733ENST00000510413ALDH2chr12112237867+LRBAchr4151793907-0.0007469650.999253

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Fusion Genomic Features for ALDH2-LRBA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ALDH2-LRBA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:112237867/chr4:151793907)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALDH2

P05091

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALDH2chr12:112237867chr4:151793907ENST00000261733+1113262_267468518.0Nucleotide bindingNAD
HgeneALDH2chr12:112237867chr4:151793907ENST00000416293+1012262_267421471.0Nucleotide bindingNAD
TgeneLRBAchr12:112237867chr4:151793907ENST0000035711516581006_10537212864.0Coiled coilOntology_term=ECO:0000255
TgeneLRBAchr12:112237867chr4:151793907ENST0000051041316571006_10537212852.0Coiled coilOntology_term=ECO:0000255
TgeneLRBAchr12:112237867chr4:151793907ENST0000035711516581990_19947212864.0Compositional biasNote=Poly-Arg
TgeneLRBAchr12:112237867chr4:151793907ENST0000051041316571990_19947212852.0Compositional biasNote=Poly-Arg
TgeneLRBAchr12:112237867chr4:151793907ENST0000035711516582073_21817212864.0DomainBEACH-type PH
TgeneLRBAchr12:112237867chr4:151793907ENST0000035711516582200_24897212864.0DomainBEACH
TgeneLRBAchr12:112237867chr4:151793907ENST0000051041316572073_21817212852.0DomainBEACH-type PH
TgeneLRBAchr12:112237867chr4:151793907ENST0000051041316572200_24897212852.0DomainBEACH
TgeneLRBAchr12:112237867chr4:151793907ENST0000035711516581301_13437212864.0RepeatNote=WD 1
TgeneLRBAchr12:112237867chr4:151793907ENST0000035711516582591_26337212864.0RepeatNote=WD 2
TgeneLRBAchr12:112237867chr4:151793907ENST0000035711516582636_26797212864.0RepeatNote=WD 3
TgeneLRBAchr12:112237867chr4:151793907ENST0000035711516582695_27357212864.0RepeatNote=WD 4
TgeneLRBAchr12:112237867chr4:151793907ENST0000035711516582777_28167212864.0RepeatNote=WD 5
TgeneLRBAchr12:112237867chr4:151793907ENST0000035711516582819_28587212864.0RepeatNote=WD 6
TgeneLRBAchr12:112237867chr4:151793907ENST0000051041316571301_13437212852.0RepeatNote=WD 1
TgeneLRBAchr12:112237867chr4:151793907ENST0000051041316572591_26337212852.0RepeatNote=WD 2
TgeneLRBAchr12:112237867chr4:151793907ENST0000051041316572636_26797212852.0RepeatNote=WD 3
TgeneLRBAchr12:112237867chr4:151793907ENST0000051041316572695_27357212852.0RepeatNote=WD 4
TgeneLRBAchr12:112237867chr4:151793907ENST0000051041316572777_28167212852.0RepeatNote=WD 5
TgeneLRBAchr12:112237867chr4:151793907ENST0000051041316572819_28587212852.0RepeatNote=WD 6
TgeneLRBAchr12:112237867chr4:151793907ENST0000035711516581531_15487212864.0TransmembraneHelical
TgeneLRBAchr12:112237867chr4:151793907ENST0000051041316571531_15487212852.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ALDH2-LRBA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3879_3879_1_ALDH2-LRBA_ALDH2_chr12_112237867_ENST00000261733_LRBA_chr4_151793907_ENST00000510413_length(transcript)=9049nt_BP=1467nt
TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC
CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTT
CATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGA
AGGGGACAAGGAAGATGTGGACAAGGCAGTGAAGGCCGCCCGGGCCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACA
CAGGGGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCGGCCTTGGAGACCCTGGACAATGGCAAGCC
CTATGTCATCTCCTACCTGGTGGATTTGGACATGGTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAAC
CATCCCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCAGATCATTCCGTGGAATTTCCCGCTCCT
GATGCAAGCATGGAAGCTGGGCCCAGCCTTGGCAACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTA
TGTGGCCAACCTGATCAAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGATTTGGCCCCACGGCTGGGGCCGCCATTGC
CTCCCATGAGGATGTGGACAAAGTGGCATTCACAGGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAA
GAGAGTGACCTTGGAGCTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATGGATTGGGCCGTGGAACAGGCCCACTTCGC
CCTGTTCTTCAACCAGGGCCAGTGCTGCTGTGCCGGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGAGCGGAGCGT
TGCCCGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCGCAGGTGGATGAAACTCAGTTTAAGAAGAT
CCTCGGCTACATCAACACGGGGAAGCAAGAGGGGGCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCC
CACTGTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTGATGCAGATCCTGAAGTTCAAGACCAT
AGAGGAGGTTGTTGGGAGAGCCAACAATTCCACGTACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTC
CCAGGCCCTCCAGGCGGGCACTGTGTGTGTTATCTACAAACTTCTGGCATCGAAAAGTGAAGGAATCAGGGTACAAGCTCTTAAGGCAAT
GGGTTATTTTTTAAAACATCTGGCCCCAAAGAGGAAAGCAGAAGTCATGCTTGGACATGGATTGTTTTCATTGCTAGCTGAAAGGCTCAT
GCTTCAGACAAATTTAATCACAATGACCACATATAATGTGCTGTTTGAGATTCTTATAGAACAGATTGGTACTCAGGTGATACATAAACA
GCATCCAGATCCTGATTCTTCAGTGAAGATACAAAACCCTCAGATACTAAAAGTAATTGCGACCCTACTTCGAAATTCTCCCCAGTGCCC
AGAGAGCATGGAGGTTCGCAGAGCCTTTCTTTCTGACATGATTAAACTTTTTAATAACAGTAGAGAAAACAGGAGGAGCTTGCTACAATG
CTCTGTGTGGCAAGAATGGATGCTTTCTCTCTGCTATTTTAATCCTAAGAATTCAGATGAGCAAAAGATAACAGAAATGGTATACGCCAT
ATTCAGAATCCTGCTTTACCATGCAGTCAAATATGAGTGGGGTGGCTGGCGTGTATGGGTAGACACTTTATCAATCACTCATTCAAAGGT
CACTTTTGAAATACACAAAGAAAACCTTGCCAATATATTTAGGGAACAGCAAGGAAAAGTTGATGAAGAAATAGGGCTGTGTTCTTCAAC
TTCAGTTCAAGCAGCCTCTGGCATTAGAAGGGATATTAATGTTTCAGTAGGATCCCAGCAACCAGATACGAAGGATTCTCCTGTCTGTCC
TCATTTCACCACAAATGGTAATGAAAATTCAAGTATAGAGAAGACAAGTTCACTAGAATCTGCATCTAATATTGAACTGCAAACTACTAA
TACATCTTATGAAGAAATGAAAGCTGAGCAAGAAAATCAGGAGTTACCAGATGAAGGCACTTTGGAAGAAACACTGACAAATGAGACAAG
GAATGCAGATGATTTAGAAGTATCTTCTGACATAATAGAAGCTGTGGCTATTTCCTCTAATTCTTTTATAACAACTGGCAAAGATTCAAT
GACTGTCAGTGAAGTAACTGCTTCTATAAGTTCTCCTTCAGAAGAGGATGCCTCAGAGATGCCAGAATTCTTGGATAAATCTATAGTAGA
GGAAGAGGAAGATGATGATTATGTGGAACTGAAAGTAGAAGGCAGTCCTACTGAGGAAGCTAATCTACCCACAGAGCTCCAAGATAACAG
TTTGTCTCCAGCTGCATCTGAAGCCGGTGAAAAACTGGACATGTTTGGTAATGATGACAAATTAATATTTCAAGAAGGAAAACCTGTTAC
TGAAAAGCAAACTGATACTGAAACTCAAGATTCTAAAGATTCTGGAATTCAGACTATGACAGCATCAGGGTCTTCAGCTATGTCACCAGA
AACTACTGTTTCCCAAATAGCTGTAGAATCAGACCTTGGTCAGATGCTGGAGGAAGGGAAGAAAGCAACTAACCTCACTAGAGAAACCAA
ATTAATTAATGATTGTCATGGTAGTGTCTCTGAGGCTTCTTCTGAGCAAAAGATTGCGAAGTTGGATGTTTCCAATGTTGCTACAGATAC
TGAGAGGCTGGAGTTGAAGGCCAGTCCCAACGTGGAAGCACCTCAACCTCATCGACATGTGCTTGAGATATCAAGGCAACATGAGCAGCC
AGGGCAAGGAATAGCACCAGATGCAGTTAATGGACAAAGGAGGGATTCCAGATCTACTGTGTTTCGTATTCCTGAGTTCAACTGGTCTCA
GATGCATCAACGTTTGCTCACTGATCTATTATTTTCAATAGAAACAGATATACAGATGTGGAGAAGCCATTCAACAAAGACAGTTATGGA
CTTCGTGAATAGCAGTGATAATGTCATCTTTGTACACAACACAATTCATCTCATCTCTCAAGTGATGGACAATATGGTCATGGCTTGTGG
GGGTATACTGCCATTGCTTTCAGCTGCTACATCGGCTACACATGAACTGGAAAATATTGAACCTACTCAAGGCCTTTCAATAGAAGCCTC
TGTGACATTTTTGCAGAGGCTAATTAGCCTTGTGGATGTGCTTATATTTGCAAGTTCTCTTGGCTTTACTGAAATTGAAGCTGAAAAAAG
TATGTCATCTGGAGGAATTTTGCGGCAGTGTCTCCGACTAGTTTGTGCAGTCGCAGTAAGGAATTGCTTGGAGTGTCAACAGCATTCACA
ACTGAAAACTAGGGGAGATAAAGCCTTGAAACCAATGCATAGCCTTATTCCTTTAGGGAAATCTGCAGCGAAGAGCCCAGTGGACATTGT
GACTGGCGGTATATCTCCAGTAAGAGATCTTGACAGGCTTCTACAGGACATGGATATTAATCGGCTTAGGGCAGTTGTTTTCAGAGACAT
AGAGGATAGCAAACAAGCTCAATTTTTAGCCTTGGCAGTAGTATACTTTATCTCTGTTCTTATGGTCTCCAAGTACAGAGACATTTTGGA
ACCCCAAAATGAAAGGCATAGCCAGTCATGTACAGAAACTGGCAGTGAAAATGAGAATGTATCACTCTCTGAAATCACACCAGCAGCATT
CAGCACTTTAACTACGGCATCAGTGGAAGAATCTGAAAGCACATCATCTGCTCGAAGGAGGGACTCAGGCATTGGGGAAGAAACAGCCAC
TGGTTTAGGAAGCCATGTGGAAGTAACTCCTCACACAGCACCTCCTGGTGTCAGTGCAGGCCCAGATGCAATCAGCGAGGTGCTATCTAC
TCTTTCTTTAGAAGTCAATAAGTCTCCGGAAACCAAAAATGATAGAGGAAATGACTTGGACACTAAGGCTACACCGTCAGTTTCAGTTTC
AAAAAACGTCAATGTGAAAGACATTCTCCGAAGCTTGGTTAACATACCAGCAGATGGAGTCACAGTGGATCCTGCCCTTCTGCCACCAGC
CTGCCTTGGAGCCCTTGGTGATCTATCTGTGGAACAACCCGTGCAGTTCAGATCTTTTGACAGAAGTGTCATTGTTGCAGCAAAAAAGTC
AGCAGTCTCACCTTCCACCTTTAATACAAGCATACCTACCAATGCTGTCAGTGTGGTTTCCTCAGTAGATTCAGCCCAAGCCTCAGATAT
GGGAGGAGAATCACCAGGCAGTAGATCATCTAATGCAAAATTGCCCTCAGTTCCAACAGTTGATTCAGTTTCACAAGATCCGGTTTCAAA
TATGAGTATTACAGAGAGGCTTGAACACGCTTTGGAAAAGGCAGCTCCTCTCCTTCGTGAGATTTTTGTGGATTTTGCACCTTTTCTTTC
TCGGACACTTTTGGGTAGCCATGGACAAGAACTGCTTATAGAAGGAACAAGTCTGGTTTGCATGAAGTCGAGTAGTTCAGTTGTGGAATT
GGTTATGCTACTGTGTTCTCAGGAGTGGCAAAATTCTATTCAGAAGAATGCAGGCCTTGCTTTTATCGAACTTGTCAATGAAGGAAGGTT
GCTTAGCCAGACAATGAAGGATCATCTAGTAAGAGTAGCAAATGAAGCTGAATTTATCCTGAGCAGGCAGAGAGCAGAAGATATTCACAG
ACATGCGGAATTTGAGTCACTGTGTGCCCAGTATTCTGCAGACAAACGAGAAGATGAGAAGATGTGTGATCATTTGATAAGAGCAGCAAA
ATATCGTGACCACGTGACAGCAACTCAACTAATCCAGAAAATTATCAACATTCTCACAGACAAGCATGGAGCCTGGGGAAATTCTGCAGT
GAGTCGTCCTCTTGAGTTCTGGCGCCTTGACTACTGGGAAGATGACTTGCGGCGCCGGCGACGATTTGTGCGTAACCCTCTAGGATCGAC
ACATCCTGAAGCGACACTAAAAACAGCCGTGGAACATGCCACAGATGAAGATATCCTTGCTAAAGGAAAACAGTCCATCAGGAGTCAGGC
TTTAGGAAATCAGAACTCAGAAAACGAGATCCTCCTGGAAGGCGATGATGATACTCTGTCATCCGTGGATGAGAAAGATTTAGAGAATCT
TGCCGGTCCTGTTAGCCTGAGCACACCAGCTCAGCTTGTGGCCCCCTCTGTTGTAGTAAAGGGCACTCTTTCTGTCACCTCCTCCGAACT
CTATTTTGAGGTGGATGAAGAGGATCCTAACTTCAAAAAAATCGACCCCAAGATCTTGGCATATACAGAAGGGCTGCATGGAAAATGGCT
GTTCACAGAGATACGATCAATCTTTTCTCGTCGTTATCTTTTGCAAAATACAGCCCTGGAGATCTTTATGGCAAACAGAGTTGCTGTGAT
GTTCAACTTCCCAGACCCTGCAACAGTAAAGAAAGTGGTTAACTATCTACCTCGTGTTGGCGTTGGAACAAGTTTTGGATTGCCTCAAAC
CAGACGTATTTCATTAGCTAGTCCACGTCAGCTTTTTAAGGCTTCTAATATGACCCAGCGATGGCAACACAGAGAGATATCTAATTTTGA
GTACTTGATGTTTCTCAACACGATAGCAGGACGGAGTTATAATGACTTAAATCAGTATCCAGTGTTTCCTTGGGTCATCACTAATTATGA
ATCAGAAGAACTGGATCTTACCTTGCCCACCAACTTCAGAGATTTGTCCAAGCCAATAGGAGCTCTGAACCCAAAAAGAGCAGCATTCTT
CGCTGAGCGTTATGAATCATGGGAAGATGATCAAGTTCCAAAGTTTCACTATGGTACTCATTACTCAACTGCAAGTTTTGTTCTTGCATG
GCTGCTAAGAATAGAACCCTTTACAACTTATTTCCTAAATTTGCAAGGAGGCAAATTTGATCATGCAGATCGAACTTTTTCATCAATTTC
CAGAGCTTGGCGAAACAGTCAGCGTGATACCTCTGATATTAAGGAGTTGATCCCTGAATTTTATTATCTCCCTGAGATGTTTGTCAACTT
CAATAATTATAATCTTGGAGTGATGGATGATGGGACAGTAGTGTCTGATGTCGAACTTCCTCCTTGGGCCAAAACCTCAGAAGAATTTGT
TCACATAAACAGATTGGCCCTGGAGAGTGAATTTGTTTCCTGCCAGCTTCACCAATGGATTGATCTCATTTTTGGCTATAAACAGCAAGG
ACCAGAAGCTGTCCGAGCCCTCAATGTGTTCTATTACTTGACCTATGAAGGAGCTGTCAATCTGAATTCAATAACTGATCCTGTGTTGAG
AGAGGCTGTTGAAGCTCAAATCCGAAGTTTTGGACAGACTCCTTCTCAACTACTCATAGAGCCCCATCCTCCCAGAGGTTCTGCCATGCA
AGTGAGTCCATTGATGTTCACAGACAAAGCCCAGCAGGATGTTATCATGGTCCTCAAGTTTCCCTCCAACTCCCCTGTTACTCACGTGGC
AGCCAACACCCAGCCTGGTTTGGCAACTCCCGCTGTGATCACAGTCACTGCTAACAGGTTATTTGCGGTGAACAAATGGCACAACCTTCC
TGCTCATCAAGGTGCTGTACAAGACCAGCCATACCAGCTGCCAGTGGAAATCGATCCTCTCATAGCCAGCAATACAGGAATGCACAGGAG
GCAAATCACTGACCTTTTAGACCAAAGTATTCAAGTGCATTCCCAGTGCTTTGTCATCACTTCAGACAACCGCTATATTCTCGTCTGTGG
CTTCTGGGATAAAAGTTTCAGAGTCTATTCTACAGACACAGGAAGATTGATCCAAGTGGTGTTTGGCCATTGGGATGTCGTCACTTGCCT
TGCTCGTTCTGAGTCATATATTGGGGGAAATTGCTACATTCTCTCAGGGTCACGTGATGCAACTCTTTTGCTGTGGTATTGGAATGGAAA
ATGCAGTGGGATTGGAGATAACCCAGGTGAGACTGCTGCTCCTCGGGCCATTTTGACCGGCCATGACTATGAGGTCACATGTGCTGCGGT
GTGTGCGGAGCTAGGCCTGGTGTTGAGTGGTTCACAAGAAGGACCATGTCTCATACATTCCATGAATGGAGACTTGTTGAGGACCTTGGA
GGGTCCTGAAAACTGCCTGAAACCAAAACTCATTCAGGCTTCAAGAGAGGGTCATTGTGTCATATTCTATGAAAACGGCCTCTTCTGTAC
ATTCAGTGTGAATGGAAAACTCCAGGCCACGATGGAAACAGATGATAACATAAGAGCCATCCAGCTGAGCCGAGATGGGCAGTACCTGCT
CACAGGAGGAGACAGAGGAGTGGTCGTGGTCCGGCAGGTGTCGGACCTCAAGCAGCTCTTTGCCTATCCAGGATGTGACGCTGGAATCCG
GGCCATGGCGCTGTCTTACGACCAGAGGTGCATCATTTCTGGCATGGCTTCAGGAAGCATTGTGCTATTTTACAACGACTTTAACCGGTG
GCATCATGAATACCAAACCCGCTACTGATGGTGACAGCTGTACATCAACTCTGCCCCTAGGATGAGCAGAAGTACCTGGAGCATCATTCT
CTTCTACCACATCTGAATGTAACTTAAATTTGCTCAAAGAAGCAAAATATTTTTTAAAGTTATTAATAATTGCTATTTTTGTAGTCTTTG
CTTGACTTTTTTGGGGGGGATTAGCAAAGCAGAAAACTGGCTGCTGGGTTCTGTAGTTTTAAAAAATCTATATTTTTAGTCATAATGAGA
AGTCTATTTTCACCAATTATGGAAACATACAGTGGAGCAAGTAAACCACTTATTCCAGCTATAATATTATGAAGAACATTTCCCATGCAT
CTACAAGCTTGAGAAATAGGATTTTCACAGTGGGGAAGTGGGTTACAATATTGGAATAGGAAAATTTGATGCTGTAATTTGGGTCCTGTA
TTTTTCCAAACAACTGTGCTTCTTCAGCACTAATATTTCTGGGATTTAAATAGTAATGTTTAAATTATGGTAAATGTAATTTAAAACATC
TCAATTAAGTCTGTCTATCAATATTGTTCTTCAAGCATGTTTTAGACCTAGAAAAGTATGGTTTGGGGGAGGCTATTTTATTGTGTGGTT
AGCACAAGGAATCTAATTTATAGCAAGTGTGAAATAGTTACCATTTTTTCCTGATCTGTCATCTTCATAGCACAACAAAACGAAATGATG
GAAATGCTCTTGAGCTCACAACATTTGTTTTTCTTTTAAAGTAAATGCAAGTACCAAAGCTCACTACTGCGGTTTGCCTGTGCCTGGACA
ATGAGGCGGAGCCACTGTTGTTTTGTTGGGGCACCCCCTTCCCTCCCCGGGTTTGCAAATAGAGGCTACCGGGTGCTGTATTCAGCAACA
CCTGTTTTACTATTTGTTATTAAACTATCATCTCCACCTTCCTTTTGATTAGCAATTTGTACTAAGAAACGAAACAATGTTATTTGGTGG
TGTATAATTCTACTTTTCTAGTAGATTACTGTGTGGAATTCTGTGAAAAATATTTGAGAAAAGGCCTGTATTGCATAAATAAATTCTTTG
TATGTTGTGAACTTTGATCTCTATTTCTCTTGCAACAGACTTCAAGTGGTCCCTCTTTTTTTCCTACACACTCAGCTCTTCTCTAAAAGC

>3879_3879_1_ALDH2-LRBA_ALDH2_chr12_112237867_ENST00000261733_LRBA_chr4_151793907_ENST00000510413_length(amino acids)=2598AA_BP=469
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLG
SPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVI
QVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFT
KDLDKANYLSQALQAGTVCVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIE
QIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDE
QKITEMVYAIFRILLYHAVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQ
PDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSN
SFITTGKDSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDK
LIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAK
LDVSNVATDTERLELKASPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMW
RSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSL
GFTEIEAEKSMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDIN
RLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRR
DSGIGEETATGLGSHVEVTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGV
TVDPALLPPACLGALGDLSVEQPVQFRSFDRSVIVAAKKSAVSPSTFNTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTV
DSVSQDPVSNMSITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLA
FIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTD
KHGAWGNSAVSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLS
SVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALE
IFMANRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYP
VFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFD
HADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWI
DLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKF
PSNSPVTHVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVIT
SDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGETAAPRAILTG
HDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAI

--------------------------------------------------------------
>3879_3879_2_ALDH2-LRBA_ALDH2_chr12_112237867_ENST00000261733_LRBA_chr4_151793907_ENST00000535741_length(transcript)=9141nt_BP=1467nt
TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC
CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTT
CATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGA
AGGGGACAAGGAAGATGTGGACAAGGCAGTGAAGGCCGCCCGGGCCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACA
CAGGGGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCGGCCTTGGAGACCCTGGACAATGGCAAGCC
CTATGTCATCTCCTACCTGGTGGATTTGGACATGGTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAAC
CATCCCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCAGATCATTCCGTGGAATTTCCCGCTCCT
GATGCAAGCATGGAAGCTGGGCCCAGCCTTGGCAACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTA
TGTGGCCAACCTGATCAAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGATTTGGCCCCACGGCTGGGGCCGCCATTGC
CTCCCATGAGGATGTGGACAAAGTGGCATTCACAGGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAA
GAGAGTGACCTTGGAGCTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATGGATTGGGCCGTGGAACAGGCCCACTTCGC
CCTGTTCTTCAACCAGGGCCAGTGCTGCTGTGCCGGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGAGCGGAGCGT
TGCCCGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCGCAGGTGGATGAAACTCAGTTTAAGAAGAT
CCTCGGCTACATCAACACGGGGAAGCAAGAGGGGGCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCC
CACTGTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTGATGCAGATCCTGAAGTTCAAGACCAT
AGAGGAGGTTGTTGGGAGAGCCAACAATTCCACGTACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTC
CCAGGCCCTCCAGGCGGGCACTGTGTGTGTTATCTACAAACTTCTGGCATCGAAAAGTGAAGGAATCAGGGTACAAGCTCTTAAGGCAAT
GGGTTATTTTTTAAAACATCTGGCCCCAAAGAGGAAAGCAGAAGTCATGCTTGGACATGGATTGTTTTCATTGCTAGCTGAAAGGCTCAT
GCTTCAGACAAATTTAATCACAATGACCACATATAATGTGCTGTTTGAGATTCTTATAGAACAGATTGGTACTCAGGTGATACATAAACA
GCATCCAGATCCTGATTCTTCAGTGAAGATACAAAACCCTCAGATACTAAAAGTAATTGCGACCCTACTTCGAAATTCTCCCCAGTGCCC
AGAGAGCATGGAGGTTCGCAGAGCCTTTCTTTCTGACATGATTAAACTTTTTAATAACAGTAGAGAAAACAGGAGGAGCTTGCTACAATG
CTCTGTGTGGCAAGAATGGATGCTTTCTCTCTGCTATTTTAATCCTAAGAATTCAGATGAGCAAAAGATAACAGAAATGGTATACGCCAT
ATTCAGAATCCTGCTTTACCATGCAGTCAAATATGAGTGGGGTGGCTGGCGTGTATGGGTAGACACTTTATCAATCACTCATTCAAAGGT
CACTTTTGAAATACACAAAGAAAACCTTGCCAATATATTTAGGGAACAGCAAGGAAAAGTTGATGAAGAAATAGGGCTGTGTTCTTCAAC
TTCAGTTCAAGCAGCCTCTGGCATTAGAAGGGATATTAATGTTTCAGTAGGATCCCAGCAACCAGATACGAAGGATTCTCCTGTCTGTCC
TCATTTCACCACAAATGGTAATGAAAATTCAAGTATAGAGAAGACAAGTTCACTAGAATCTGCATCTAATATTGAACTGCAAACTACTAA
TACATCTTATGAAGAAATGAAAGCTGAGCAAGAAAATCAGGAGTTACCAGATGAAGGCACTTTGGAAGAAACACTGACAAATGAGACAAG
GAATGCAGATGATTTAGAAGTATCTTCTGACATAATAGAAGCTGTGGCTATTTCCTCTAATTCTTTTATAACAACTGGCAAAGATTCAAT
GACTGTCAGTGAAGTAACTGCTTCTATAAGTTCTCCTTCAGAAGAGGATGCCTCAGAGATGCCAGAATTCTTGGATAAATCTATAGTAGA
GGAAGAGGAAGATGATGATTATGTGGAACTGAAAGTAGAAGGCAGTCCTACTGAGGAAGCTAATCTACCCACAGAGCTCCAAGATAACAG
TTTGTCTCCAGCTGCATCTGAAGCCGGTGAAAAACTGGACATGTTTGGTAATGATGACAAATTAATATTTCAAGAAGGAAAACCTGTTAC
TGAAAAGCAAACTGATACTGAAACTCAAGATTCTAAAGATTCTGGAATTCAGACTATGACAGCATCAGGGTCTTCAGCTATGTCACCAGA
AACTACTGTTTCCCAAATAGCTGTAGAATCAGACCTTGGTCAGATGCTGGAGGAAGGGAAGAAAGCAACTAACCTCACTAGAGAAACCAA
ATTAATTAATGATTGTCATGGTAGTGTCTCTGAGGCTTCTTCTGAGCAAAAGATTGCGAAGTTGGATGTTTCCAATGTTGCTACAGATAC
TGAGAGGCTGGAGTTGAAGGCCAGTCCCAACGTGGAAGCACCTCAACCTCATCGACATGTGCTTGAGATATCAAGGCAACATGAGCAGCC
AGGGCAAGGAATAGCACCAGATGCAGTTAATGGACAAAGGAGGGATTCCAGATCTACTGTGTTTCGTATTCCTGAGTTCAACTGGTCTCA
GATGCATCAACGTTTGCTCACTGATCTATTATTTTCAATAGAAACAGATATACAGATGTGGAGAAGCCATTCAACAAAGACAGTTATGGA
CTTCGTGAATAGCAGTGATAATGTCATCTTTGTACACAACACAATTCATCTCATCTCTCAAGTGATGGACAATATGGTCATGGCTTGTGG
GGGTATACTGCCATTGCTTTCAGCTGCTACATCGGCTACACATGAACTGGAAAATATTGAACCTACTCAAGGCCTTTCAATAGAAGCCTC
TGTGACATTTTTGCAGAGGCTAATTAGCCTTGTGGATGTGCTTATATTTGCAAGTTCTCTTGGCTTTACTGAAATTGAAGCTGAAAAAAG
TATGTCATCTGGAGGAATTTTGCGGCAGTGTCTCCGACTAGTTTGTGCAGTCGCAGTAAGGAATTGCTTGGAGTGTCAACAGCATTCACA
ACTGAAAACTAGGGGAGATAAAGCCTTGAAACCAATGCATAGCCTTATTCCTTTAGGGAAATCTGCAGCGAAGAGCCCAGTGGACATTGT
GACTGGCGGTATATCTCCAGTAAGAGATCTTGACAGGCTTCTACAGGACATGGATATTAATCGGCTTAGGGCAGTTGTTTTCAGAGACAT
AGAGGATAGCAAACAAGCTCAATTTTTAGCCTTGGCAGTAGTATACTTTATCTCTGTTCTTATGGTCTCCAAGTACAGAGACATTTTGGA
ACCCCAAAATGAAAGGCATAGCCAGTCATGTACAGAAACTGGCAGTGAAAATGAGAATGTATCACTCTCTGAAATCACACCAGCAGCATT
CAGCACTTTAACTACGGCATCAGTGGAAGAATCTGAAAGCACATCATCTGCTCGAAGGAGGGACTCAGGCATTGGGGAAGAAACAGCCAC
TGGTTTAGGAAGCCATGTGGAAGTAACTCCTCACACAGCACCTCCTGGTGTCAGTGCAGGCCCAGATGCAATCAGCGAGGTGCTATCTAC
TCTTTCTTTAGAAGTCAATAAGTCTCCGGAAACCAAAAATGATAGAGGAAATGACTTGGACACTAAGGCTACACCGTCAGTTTCAGTTTC
AAAAAACGTCAATGTGAAAGACATTCTCCGAAGCTTGGTTAACATACCAGCAGATGGAGTCACAGTGGATCCTGCCCTTCTGCCACCAGC
CTGCCTTGGAGCCCTTGGTGATCTATCTGTGGAACAACCCGTGCAGTTCAGATCTTTTGACAGAAGTGTCATTGTTGCAGCAAAAAAGTC
AGCAGTCTCACCTTCCACCTTTAATACAAGCATACCTACCAATGCTGTCAGTGTGGTTTCCTCAGTAGATTCAGCCCAAGCCTCAGATAT
GGGAGGAGAATCACCAGGCAGTAGATCATCTAATGCAAAATTGCCCTCAGTTCCAACAGTTGATTCAGTTTCACAAGATCCGGTTTCAAA
TATGAGTATTACAGAGAGGCTTGAACACGCTTTGGAAAAGGCAGCTCCTCTCCTTCGTGAGATTTTTGTGGATTTTGCACCTTTTCTTTC
TCGGACACTTTTGGGTAGCCATGGACAAGAACTGCTTATAGAAGGAACAAGTCTGGTTTGCATGAAGTCGAGTAGTTCAGTTGTGGAATT
GGTTATGCTACTGTGTTCTCAGGAGTGGCAAAATTCTATTCAGAAGAATGCAGGCCTTGCTTTTATCGAACTTGTCAATGAAGGAAGGTT
GCTTAGCCAGACAATGAAGGATCATCTAGTAAGAGTAGCAAATGAAGCTGAATTTATCCTGAGCAGGCAGAGAGCAGAAGATATTCACAG
ACATGCGGAATTTGAGTCACTGTGTGCCCAGTATTCTGCAGACAAACGAGAAGATGAGAAGATGTGTGATCATTTGATAAGAGCAGCAAA
ATATCGTGACCACGTGACAGCAACTCAACTAATCCAGAAAATTATCAACATTCTCACAGACAAGCATGGAGCCTGGGGAAATTCTGCAGT
GAGTCGTCCTCTTGAGTTCTGGCGCCTTGACTACTGGGAAGATGACTTGCGGCGCCGGCGACGATTTGTGCGTAACCCTCTAGGATCGAC
ACATCCTGAAGCGACACTAAAAACAGCCGTGGAACATGCCACAGATGAAGATATCCTTGCTAAAGGAAAACAGTCCATCAGGAGTCAGGC
TTTAGGAAATCAGAACTCAGAAAACGAGATCCTCCTGGAAGGCGATGATGATACTCTGTCATCCGTGGATGAGAAAGATTTAGAGAATCT
TGCCGGTCCTGTTAGCCTGAGCACACCAGCTCAGCTTGTGGCCCCCTCTGTTGTAGTAAAGGGCACTCTTTCTGTCACCTCCTCCGAACT
CTATTTTGAGGTGGATGAAGAGGATCCTAACTTCAAAAAAATCGACCCCAAGATCTTGGCATATACAGAAGGGCTGCATGGAAAATGGCT
GTTCACAGAGATACGATCAATCTTTTCTCGTCGTTATCTTTTGCAAAATACAGCCCTGGAGATCTTTATGGCAAACAGAGTTGCTGTGAT
GTTCAACTTCCCAGACCCTGCAACAGTAAAGAAAGTGGTTAACTATCTACCTCGTGTTGGCGTTGGAACAAGTTTTGGATTGCCTCAAAC
CAGACGTATTTCATTAGCTAGTCCACGTCAGCTTTTTAAGGCTTCTAATATGACCCAGCGATGGCAACACAGAGAGATATCTAATTTTGA
GTACTTGATGTTTCTCAACACGATAGCAGGACGGAGTTATAATGACTTAAATCAGTATCCAGTGTTTCCTTGGGTCATCACTAATTATGA
ATCAGAAGAACTGGATCTTACCTTGCCCACCAACTTCAGAGATTTGTCCAAGCCAATAGGAGCTCTGAACCCAAAAAGAGCAGCATTCTT
CGCTGAGCGTTATGAATCATGGGAAGATGATCAAGTTCCAAAGTTTCACTATGGTACTCATTACTCAACTGCAAGTTTTGTTCTTGCATG
GCTGCTAAGAATAGAACCCTTTACAACTTATTTCCTAAATTTGCAAGGAGGCAAATTTGATCATGCAGATCGAACTTTTTCATCAATTTC
CAGAGCTTGGCGAAACAGTCAGCGTGATACCTCTGATATTAAGGAGTTGATCCCTGAATTTTATTATCTCCCTGAGATGTTTGTCAACTT
CAATAATTATAATCTTGGAGTGATGGATGATGGGACAGTAGTGTCTGATGTCGAACTTCCTCCTTGGGCCAAAACCTCAGAAGAATTTGT
TCACATAAACAGATTGGCCCTGGAGAGTGAATTTGTTTCCTGCCAGCTTCACCAATGGATTGATCTCATTTTTGGCTATAAACAGCAAGG
ACCAGAAGCTGTCCGAGCCCTCAATGTGTTCTATTACTTGACCTATGAAGGAGCTGTCAATCTGAATTCAATAACTGATCCTGTGTTGAG
AGAGGCTGTTGAAGCTCAAATCCGAAGTTTTGGACAGACTCCTTCTCAACTACTCATAGAGCCCCATCCTCCCAGAGGTTCTGCCATGCA
AGTGAGTCCATTGATGTTCACAGACAAAGCCCAGCAGGATGTTATCATGGTCCTCAAGTTTCCCTCCAACTCCCCTGTTACTCACGTGGC
AGCCAACACCCAGCCTGGTTTGGCAACTCCCGCTGTGATCACAGTCACTGCTAACAGGTTATTTGCGGTGAACAAATGGCACAACCTTCC
TGCTCATCAAGGTGCTGTACAAGACCAGCCATACCAGCTGCCAGTGGAAATCGATCCTCTCATAGCCAGCAATACAGGAATGCACAGGAG
GCAAATCACTGACCTTTTAGACCAAAGTATTCAAGTGCATTCCCAGTGCTTTGTCATCACTTCAGACAACCGCTATATTCTCGTCTGTGG
CTTCTGGGATAAAAGTTTCAGAGTCTATTCTACAGACACAGGAAGATTGATCCAAGTGGTGTTTGGCCATTGGGATGTCGTCACTTGCCT
TGCTCGTTCTGAGTCATATATTGGGGGAAATTGCTACATTCTCTCAGGGTCACGTGATGCAACTCTTTTGCTGTGGTATTGGAATGGAAA
ATGCAGTGGGATTGGAGATAACCCAGGCAGTGAGACTGCTGCTCCTCGGGCCATTTTGACCGGCCATGACTATGAGGTCACATGTGCTGC
GGTGTGTGCGGAGCTAGGCCTGGTGTTGAGTGGTTCACAAGAAGGACCATGTCTCATACATTCCATGAATGGAGACTTGTTGAGGACCTT
GGAGGGTCCTGAAAACTGCCTGAAACCAAAACTCATTCAGGCTTCAAGAGAGGGTCATTGTGTCATATTCTATGAAAACGGCCTCTTCTG
TACATTCAGTGTGAATGGAAAACTCCAGGCCACGATGGAAACAGATGATAACATAAGAGCCATCCAGCTGAGCCGAGATGGGCAGTACCT
GCTCACAGGAGGAGACAGAGGAGTGGTCGTGGTCCGGCAGGTGTCGGACCTCAAGCAGCTCTTTGCCTATCCAGGATGTGACGCTGGAAT
CCGGGCCATGGCGCTGTCTTACGACCAGAGGTGCATCATTTCTGGCATGGCTTCAGGAAGCATTGTGCTATTTTACAACGACTTTAACCG
GTGGCATCATGAATACCAAACCCGCTACTGATGGTGACAGCTGTACATCAACTCTGCCCCTAGGATGAGCAGAAGTACCTGGAGCATCAT
TCTCTTCTACCACATCTGAATGTAACTTAAATTTGCTCAAAGAAGCAAAATATTTTTTAAAGTTATTAATAATTGCTATTTTTGTAGTCT
TTGCTTGACTTTTTTGGGGGGGATTAGCAAAGCAGAAAACTGGCTGCTGGGTTCTGTAGTTTTAAAAAATCTATATTTTTAGTCATAATG
AGAAGTCTATTTTCACCAATTATGGAAACATACAGTGGAGCAAGTAAACCACTTATTCCAGCTATAATATTATGAAGAACATTTCCCATG
CATCTACAAGCTTGAGAAATAGGATTTTCACAGTGGGGAAGTGGGTTACAATATTGGAATAGGAAAATTTGATGCTGTAATTTGGGTCCT
GTATTTTTCCAAACAACTGTGCTTCTTCAGCACTAATATTTCTGGGATTTAAATAGTAATGTTTAAATTATGGTAAATGTAATTTAAAAC
ATCTCAATTAAGTCTGTCTATCAATATTGTTCTTCAAGCATGTTTTAGACCTAGAAAAGTATGGTTTGGGGGAGGCTATTTTATTGTGTG
GTTAGCACAAGGAATCTAATTTATAGCAAGTGTGAAATAGTTACCATTTTTTCCTGATCTGTCATCTTCATAGCACAACAAAACGAAATG
ATGGAAATGCTCTTGAGCTCACAACATTTGTTTTTCTTTTAAAGTAAATGCAAGTACCAAAGCTCACTACTGCGGTTTGCCTGTGCCTGG
ACAATGAGGCGGAGCCACTGTTGTTTTGTTGGGGCACCCCCTTCCCTCCCCGGGTTTGCAAATAGAGGCTACCGGGTGCTGTATTCAGCA
ACACCTGTTTTACTATTTGTTATTAAACTATCATCTCCACCTTCCTTTTGATTAGCAATTTGTACTAAGAAACGAAACAATGTTATTTGG
TGGTGTATAATTCTACTTTTCTAGTAGATTACTGTGTGGAATTCTGTGAAAAATATTTGAGAAAAGGCCTGTATTGCATAAATAAATTCT
TTGTATGTTGTGAACTTTGATCTCTATTTCTCTTGCAACAGACTTCAAGTGGTCCCTCTTTTTTTCCTACACACTCAGCTCTTCTCTAAA
AGCAAGGATTTGGAATGAACAATTCAGTTTGACAGAAAAAGCTGAATAAAATGGCATCTGTAATTGAATTGTTGGAAATGCCTTTTTTGC

>3879_3879_2_ALDH2-LRBA_ALDH2_chr12_112237867_ENST00000261733_LRBA_chr4_151793907_ENST00000535741_length(amino acids)=2599AA_BP=469
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLG
SPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVI
QVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFT
KDLDKANYLSQALQAGTVCVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIE
QIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDE
QKITEMVYAIFRILLYHAVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQ
PDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSN
SFITTGKDSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDK
LIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAK
LDVSNVATDTERLELKASPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMW
RSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSL
GFTEIEAEKSMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDIN
RLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRR
DSGIGEETATGLGSHVEVTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGV
TVDPALLPPACLGALGDLSVEQPVQFRSFDRSVIVAAKKSAVSPSTFNTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTV
DSVSQDPVSNMSITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLA
FIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTD
KHGAWGNSAVSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLS
SVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALE
IFMANRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYP
VFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFD
HADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWI
DLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKF
PSNSPVTHVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVIT
SDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILT
GHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRA

--------------------------------------------------------------
>3879_3879_3_ALDH2-LRBA_ALDH2_chr12_112237867_ENST00000416293_LRBA_chr4_151793907_ENST00000510413_length(transcript)=8943nt_BP=1361nt
ATTGGCTGCCGCGCGGGGCGGGGAGCGGGGTCGGCTCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCC
GCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCCCCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCC
AACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTCATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAAT
CCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGCCTTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTAC
CTGGTGGATTTGGACATGGTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACCATCCCCATTGACGGA
GACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCAGATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAG
CTGGGCCCAGCCTTGGCAACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTATGTGGCCAACCTGATC
AAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGATTTGGCCCCACGGCTGGGGCCGCCATTGCCTCCCATGAGGATGTG
GACAAAGTGGCATTCACAGGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAAGAGAGTGACCTTGGAG
CTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATGGATTGGGCCGTGGAACAGGCCCACTTCGCCCTGTTCTTCAACCAG
GGCCAGTGCTGCTGTGCCGGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGAGCGGAGCGTTGCCCGGGCCAAGTCT
CGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCGCAGGTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAAC
ACGGGGAAGCAAGAGGGGGCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCCACTGTGTTTGGAGAT
GTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTGATGCAGATCCTGAAGTTCAAGACCATAGAGGAGGTTGTTGGG
AGAGCCAACAATTCCACGTACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCCCAGGCCCTCCAGGCG
GGCACTGTGTGTGTTATCTACAAACTTCTGGCATCGAAAAGTGAAGGAATCAGGGTACAAGCTCTTAAGGCAATGGGTTATTTTTTAAAA
CATCTGGCCCCAAAGAGGAAAGCAGAAGTCATGCTTGGACATGGATTGTTTTCATTGCTAGCTGAAAGGCTCATGCTTCAGACAAATTTA
ATCACAATGACCACATATAATGTGCTGTTTGAGATTCTTATAGAACAGATTGGTACTCAGGTGATACATAAACAGCATCCAGATCCTGAT
TCTTCAGTGAAGATACAAAACCCTCAGATACTAAAAGTAATTGCGACCCTACTTCGAAATTCTCCCCAGTGCCCAGAGAGCATGGAGGTT
CGCAGAGCCTTTCTTTCTGACATGATTAAACTTTTTAATAACAGTAGAGAAAACAGGAGGAGCTTGCTACAATGCTCTGTGTGGCAAGAA
TGGATGCTTTCTCTCTGCTATTTTAATCCTAAGAATTCAGATGAGCAAAAGATAACAGAAATGGTATACGCCATATTCAGAATCCTGCTT
TACCATGCAGTCAAATATGAGTGGGGTGGCTGGCGTGTATGGGTAGACACTTTATCAATCACTCATTCAAAGGTCACTTTTGAAATACAC
AAAGAAAACCTTGCCAATATATTTAGGGAACAGCAAGGAAAAGTTGATGAAGAAATAGGGCTGTGTTCTTCAACTTCAGTTCAAGCAGCC
TCTGGCATTAGAAGGGATATTAATGTTTCAGTAGGATCCCAGCAACCAGATACGAAGGATTCTCCTGTCTGTCCTCATTTCACCACAAAT
GGTAATGAAAATTCAAGTATAGAGAAGACAAGTTCACTAGAATCTGCATCTAATATTGAACTGCAAACTACTAATACATCTTATGAAGAA
ATGAAAGCTGAGCAAGAAAATCAGGAGTTACCAGATGAAGGCACTTTGGAAGAAACACTGACAAATGAGACAAGGAATGCAGATGATTTA
GAAGTATCTTCTGACATAATAGAAGCTGTGGCTATTTCCTCTAATTCTTTTATAACAACTGGCAAAGATTCAATGACTGTCAGTGAAGTA
ACTGCTTCTATAAGTTCTCCTTCAGAAGAGGATGCCTCAGAGATGCCAGAATTCTTGGATAAATCTATAGTAGAGGAAGAGGAAGATGAT
GATTATGTGGAACTGAAAGTAGAAGGCAGTCCTACTGAGGAAGCTAATCTACCCACAGAGCTCCAAGATAACAGTTTGTCTCCAGCTGCA
TCTGAAGCCGGTGAAAAACTGGACATGTTTGGTAATGATGACAAATTAATATTTCAAGAAGGAAAACCTGTTACTGAAAAGCAAACTGAT
ACTGAAACTCAAGATTCTAAAGATTCTGGAATTCAGACTATGACAGCATCAGGGTCTTCAGCTATGTCACCAGAAACTACTGTTTCCCAA
ATAGCTGTAGAATCAGACCTTGGTCAGATGCTGGAGGAAGGGAAGAAAGCAACTAACCTCACTAGAGAAACCAAATTAATTAATGATTGT
CATGGTAGTGTCTCTGAGGCTTCTTCTGAGCAAAAGATTGCGAAGTTGGATGTTTCCAATGTTGCTACAGATACTGAGAGGCTGGAGTTG
AAGGCCAGTCCCAACGTGGAAGCACCTCAACCTCATCGACATGTGCTTGAGATATCAAGGCAACATGAGCAGCCAGGGCAAGGAATAGCA
CCAGATGCAGTTAATGGACAAAGGAGGGATTCCAGATCTACTGTGTTTCGTATTCCTGAGTTCAACTGGTCTCAGATGCATCAACGTTTG
CTCACTGATCTATTATTTTCAATAGAAACAGATATACAGATGTGGAGAAGCCATTCAACAAAGACAGTTATGGACTTCGTGAATAGCAGT
GATAATGTCATCTTTGTACACAACACAATTCATCTCATCTCTCAAGTGATGGACAATATGGTCATGGCTTGTGGGGGTATACTGCCATTG
CTTTCAGCTGCTACATCGGCTACACATGAACTGGAAAATATTGAACCTACTCAAGGCCTTTCAATAGAAGCCTCTGTGACATTTTTGCAG
AGGCTAATTAGCCTTGTGGATGTGCTTATATTTGCAAGTTCTCTTGGCTTTACTGAAATTGAAGCTGAAAAAAGTATGTCATCTGGAGGA
ATTTTGCGGCAGTGTCTCCGACTAGTTTGTGCAGTCGCAGTAAGGAATTGCTTGGAGTGTCAACAGCATTCACAACTGAAAACTAGGGGA
GATAAAGCCTTGAAACCAATGCATAGCCTTATTCCTTTAGGGAAATCTGCAGCGAAGAGCCCAGTGGACATTGTGACTGGCGGTATATCT
CCAGTAAGAGATCTTGACAGGCTTCTACAGGACATGGATATTAATCGGCTTAGGGCAGTTGTTTTCAGAGACATAGAGGATAGCAAACAA
GCTCAATTTTTAGCCTTGGCAGTAGTATACTTTATCTCTGTTCTTATGGTCTCCAAGTACAGAGACATTTTGGAACCCCAAAATGAAAGG
CATAGCCAGTCATGTACAGAAACTGGCAGTGAAAATGAGAATGTATCACTCTCTGAAATCACACCAGCAGCATTCAGCACTTTAACTACG
GCATCAGTGGAAGAATCTGAAAGCACATCATCTGCTCGAAGGAGGGACTCAGGCATTGGGGAAGAAACAGCCACTGGTTTAGGAAGCCAT
GTGGAAGTAACTCCTCACACAGCACCTCCTGGTGTCAGTGCAGGCCCAGATGCAATCAGCGAGGTGCTATCTACTCTTTCTTTAGAAGTC
AATAAGTCTCCGGAAACCAAAAATGATAGAGGAAATGACTTGGACACTAAGGCTACACCGTCAGTTTCAGTTTCAAAAAACGTCAATGTG
AAAGACATTCTCCGAAGCTTGGTTAACATACCAGCAGATGGAGTCACAGTGGATCCTGCCCTTCTGCCACCAGCCTGCCTTGGAGCCCTT
GGTGATCTATCTGTGGAACAACCCGTGCAGTTCAGATCTTTTGACAGAAGTGTCATTGTTGCAGCAAAAAAGTCAGCAGTCTCACCTTCC
ACCTTTAATACAAGCATACCTACCAATGCTGTCAGTGTGGTTTCCTCAGTAGATTCAGCCCAAGCCTCAGATATGGGAGGAGAATCACCA
GGCAGTAGATCATCTAATGCAAAATTGCCCTCAGTTCCAACAGTTGATTCAGTTTCACAAGATCCGGTTTCAAATATGAGTATTACAGAG
AGGCTTGAACACGCTTTGGAAAAGGCAGCTCCTCTCCTTCGTGAGATTTTTGTGGATTTTGCACCTTTTCTTTCTCGGACACTTTTGGGT
AGCCATGGACAAGAACTGCTTATAGAAGGAACAAGTCTGGTTTGCATGAAGTCGAGTAGTTCAGTTGTGGAATTGGTTATGCTACTGTGT
TCTCAGGAGTGGCAAAATTCTATTCAGAAGAATGCAGGCCTTGCTTTTATCGAACTTGTCAATGAAGGAAGGTTGCTTAGCCAGACAATG
AAGGATCATCTAGTAAGAGTAGCAAATGAAGCTGAATTTATCCTGAGCAGGCAGAGAGCAGAAGATATTCACAGACATGCGGAATTTGAG
TCACTGTGTGCCCAGTATTCTGCAGACAAACGAGAAGATGAGAAGATGTGTGATCATTTGATAAGAGCAGCAAAATATCGTGACCACGTG
ACAGCAACTCAACTAATCCAGAAAATTATCAACATTCTCACAGACAAGCATGGAGCCTGGGGAAATTCTGCAGTGAGTCGTCCTCTTGAG
TTCTGGCGCCTTGACTACTGGGAAGATGACTTGCGGCGCCGGCGACGATTTGTGCGTAACCCTCTAGGATCGACACATCCTGAAGCGACA
CTAAAAACAGCCGTGGAACATGCCACAGATGAAGATATCCTTGCTAAAGGAAAACAGTCCATCAGGAGTCAGGCTTTAGGAAATCAGAAC
TCAGAAAACGAGATCCTCCTGGAAGGCGATGATGATACTCTGTCATCCGTGGATGAGAAAGATTTAGAGAATCTTGCCGGTCCTGTTAGC
CTGAGCACACCAGCTCAGCTTGTGGCCCCCTCTGTTGTAGTAAAGGGCACTCTTTCTGTCACCTCCTCCGAACTCTATTTTGAGGTGGAT
GAAGAGGATCCTAACTTCAAAAAAATCGACCCCAAGATCTTGGCATATACAGAAGGGCTGCATGGAAAATGGCTGTTCACAGAGATACGA
TCAATCTTTTCTCGTCGTTATCTTTTGCAAAATACAGCCCTGGAGATCTTTATGGCAAACAGAGTTGCTGTGATGTTCAACTTCCCAGAC
CCTGCAACAGTAAAGAAAGTGGTTAACTATCTACCTCGTGTTGGCGTTGGAACAAGTTTTGGATTGCCTCAAACCAGACGTATTTCATTA
GCTAGTCCACGTCAGCTTTTTAAGGCTTCTAATATGACCCAGCGATGGCAACACAGAGAGATATCTAATTTTGAGTACTTGATGTTTCTC
AACACGATAGCAGGACGGAGTTATAATGACTTAAATCAGTATCCAGTGTTTCCTTGGGTCATCACTAATTATGAATCAGAAGAACTGGAT
CTTACCTTGCCCACCAACTTCAGAGATTTGTCCAAGCCAATAGGAGCTCTGAACCCAAAAAGAGCAGCATTCTTCGCTGAGCGTTATGAA
TCATGGGAAGATGATCAAGTTCCAAAGTTTCACTATGGTACTCATTACTCAACTGCAAGTTTTGTTCTTGCATGGCTGCTAAGAATAGAA
CCCTTTACAACTTATTTCCTAAATTTGCAAGGAGGCAAATTTGATCATGCAGATCGAACTTTTTCATCAATTTCCAGAGCTTGGCGAAAC
AGTCAGCGTGATACCTCTGATATTAAGGAGTTGATCCCTGAATTTTATTATCTCCCTGAGATGTTTGTCAACTTCAATAATTATAATCTT
GGAGTGATGGATGATGGGACAGTAGTGTCTGATGTCGAACTTCCTCCTTGGGCCAAAACCTCAGAAGAATTTGTTCACATAAACAGATTG
GCCCTGGAGAGTGAATTTGTTTCCTGCCAGCTTCACCAATGGATTGATCTCATTTTTGGCTATAAACAGCAAGGACCAGAAGCTGTCCGA
GCCCTCAATGTGTTCTATTACTTGACCTATGAAGGAGCTGTCAATCTGAATTCAATAACTGATCCTGTGTTGAGAGAGGCTGTTGAAGCT
CAAATCCGAAGTTTTGGACAGACTCCTTCTCAACTACTCATAGAGCCCCATCCTCCCAGAGGTTCTGCCATGCAAGTGAGTCCATTGATG
TTCACAGACAAAGCCCAGCAGGATGTTATCATGGTCCTCAAGTTTCCCTCCAACTCCCCTGTTACTCACGTGGCAGCCAACACCCAGCCT
GGTTTGGCAACTCCCGCTGTGATCACAGTCACTGCTAACAGGTTATTTGCGGTGAACAAATGGCACAACCTTCCTGCTCATCAAGGTGCT
GTACAAGACCAGCCATACCAGCTGCCAGTGGAAATCGATCCTCTCATAGCCAGCAATACAGGAATGCACAGGAGGCAAATCACTGACCTT
TTAGACCAAAGTATTCAAGTGCATTCCCAGTGCTTTGTCATCACTTCAGACAACCGCTATATTCTCGTCTGTGGCTTCTGGGATAAAAGT
TTCAGAGTCTATTCTACAGACACAGGAAGATTGATCCAAGTGGTGTTTGGCCATTGGGATGTCGTCACTTGCCTTGCTCGTTCTGAGTCA
TATATTGGGGGAAATTGCTACATTCTCTCAGGGTCACGTGATGCAACTCTTTTGCTGTGGTATTGGAATGGAAAATGCAGTGGGATTGGA
GATAACCCAGGTGAGACTGCTGCTCCTCGGGCCATTTTGACCGGCCATGACTATGAGGTCACATGTGCTGCGGTGTGTGCGGAGCTAGGC
CTGGTGTTGAGTGGTTCACAAGAAGGACCATGTCTCATACATTCCATGAATGGAGACTTGTTGAGGACCTTGGAGGGTCCTGAAAACTGC
CTGAAACCAAAACTCATTCAGGCTTCAAGAGAGGGTCATTGTGTCATATTCTATGAAAACGGCCTCTTCTGTACATTCAGTGTGAATGGA
AAACTCCAGGCCACGATGGAAACAGATGATAACATAAGAGCCATCCAGCTGAGCCGAGATGGGCAGTACCTGCTCACAGGAGGAGACAGA
GGAGTGGTCGTGGTCCGGCAGGTGTCGGACCTCAAGCAGCTCTTTGCCTATCCAGGATGTGACGCTGGAATCCGGGCCATGGCGCTGTCT
TACGACCAGAGGTGCATCATTTCTGGCATGGCTTCAGGAAGCATTGTGCTATTTTACAACGACTTTAACCGGTGGCATCATGAATACCAA
ACCCGCTACTGATGGTGACAGCTGTACATCAACTCTGCCCCTAGGATGAGCAGAAGTACCTGGAGCATCATTCTCTTCTACCACATCTGA
ATGTAACTTAAATTTGCTCAAAGAAGCAAAATATTTTTTAAAGTTATTAATAATTGCTATTTTTGTAGTCTTTGCTTGACTTTTTTGGGG
GGGATTAGCAAAGCAGAAAACTGGCTGCTGGGTTCTGTAGTTTTAAAAAATCTATATTTTTAGTCATAATGAGAAGTCTATTTTCACCAA
TTATGGAAACATACAGTGGAGCAAGTAAACCACTTATTCCAGCTATAATATTATGAAGAACATTTCCCATGCATCTACAAGCTTGAGAAA
TAGGATTTTCACAGTGGGGAAGTGGGTTACAATATTGGAATAGGAAAATTTGATGCTGTAATTTGGGTCCTGTATTTTTCCAAACAACTG
TGCTTCTTCAGCACTAATATTTCTGGGATTTAAATAGTAATGTTTAAATTATGGTAAATGTAATTTAAAACATCTCAATTAAGTCTGTCT
ATCAATATTGTTCTTCAAGCATGTTTTAGACCTAGAAAAGTATGGTTTGGGGGAGGCTATTTTATTGTGTGGTTAGCACAAGGAATCTAA
TTTATAGCAAGTGTGAAATAGTTACCATTTTTTCCTGATCTGTCATCTTCATAGCACAACAAAACGAAATGATGGAAATGCTCTTGAGCT
CACAACATTTGTTTTTCTTTTAAAGTAAATGCAAGTACCAAAGCTCACTACTGCGGTTTGCCTGTGCCTGGACAATGAGGCGGAGCCACT
GTTGTTTTGTTGGGGCACCCCCTTCCCTCCCCGGGTTTGCAAATAGAGGCTACCGGGTGCTGTATTCAGCAACACCTGTTTTACTATTTG
TTATTAAACTATCATCTCCACCTTCCTTTTGATTAGCAATTTGTACTAAGAAACGAAACAATGTTATTTGGTGGTGTATAATTCTACTTT
TCTAGTAGATTACTGTGTGGAATTCTGTGAAAAATATTTGAGAAAAGGCCTGTATTGCATAAATAAATTCTTTGTATGTTGTGAACTTTG
ATCTCTATTTCTCTTGCAACAGACTTCAAGTGGTCCCTCTTTTTTTCCTACACACTCAGCTCTTCTCTAAAAGCAAGGATTTGGAATGAA

>3879_3879_3_ALDH2-LRBA_ALDH2_chr12_112237867_ENST00000416293_LRBA_chr4_151793907_ENST00000510413_length(amino acids)=2551AA_BP=422
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKALETLDNGKPYVISYLV
DLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKE
AGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQ
CCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQ
DGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVCVIYKLLASKSEGIRVQALKAMGYFLKHL
APKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRR
AFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYHAVKYEWGGWRVWVDTLSITHSKVTFEIHKE
NLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMK
AEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDY
VELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIA
VESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKASPNVEAPQPHRHVLEISRQHEQPGQGIAPD
AVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLS
AATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKTRGDK
ALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHS
QSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVEVTPHTAPPGVSAGPDAISEVLSTLSLEVNK
SPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGDLSVEQPVQFRSFDRSVIVAAKKSAVSPSTF
NTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTVDSVSQDPVSNMSITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSH
GQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESL
CAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLK
TAVEHATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEE
DPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLAS
PRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESW
EDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGV
MDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQI
RSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQ
DQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYI
GGNCYILSGSRDATLLLWYWNGKCSGIGDNPGETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLK
PKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSYD

--------------------------------------------------------------
>3879_3879_4_ALDH2-LRBA_ALDH2_chr12_112237867_ENST00000416293_LRBA_chr4_151793907_ENST00000535741_length(transcript)=9035nt_BP=1361nt
ATTGGCTGCCGCGCGGGGCGGGGAGCGGGGTCGGCTCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCC
GCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCCCCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCC
AACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTCATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAAT
CCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGCCTTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTAC
CTGGTGGATTTGGACATGGTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACCATCCCCATTGACGGA
GACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCAGATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAG
CTGGGCCCAGCCTTGGCAACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTATGTGGCCAACCTGATC
AAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGATTTGGCCCCACGGCTGGGGCCGCCATTGCCTCCCATGAGGATGTG
GACAAAGTGGCATTCACAGGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAAGAGAGTGACCTTGGAG
CTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATGGATTGGGCCGTGGAACAGGCCCACTTCGCCCTGTTCTTCAACCAG
GGCCAGTGCTGCTGTGCCGGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGAGCGGAGCGTTGCCCGGGCCAAGTCT
CGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCGCAGGTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAAC
ACGGGGAAGCAAGAGGGGGCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCCACTGTGTTTGGAGAT
GTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTGATGCAGATCCTGAAGTTCAAGACCATAGAGGAGGTTGTTGGG
AGAGCCAACAATTCCACGTACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCCCAGGCCCTCCAGGCG
GGCACTGTGTGTGTTATCTACAAACTTCTGGCATCGAAAAGTGAAGGAATCAGGGTACAAGCTCTTAAGGCAATGGGTTATTTTTTAAAA
CATCTGGCCCCAAAGAGGAAAGCAGAAGTCATGCTTGGACATGGATTGTTTTCATTGCTAGCTGAAAGGCTCATGCTTCAGACAAATTTA
ATCACAATGACCACATATAATGTGCTGTTTGAGATTCTTATAGAACAGATTGGTACTCAGGTGATACATAAACAGCATCCAGATCCTGAT
TCTTCAGTGAAGATACAAAACCCTCAGATACTAAAAGTAATTGCGACCCTACTTCGAAATTCTCCCCAGTGCCCAGAGAGCATGGAGGTT
CGCAGAGCCTTTCTTTCTGACATGATTAAACTTTTTAATAACAGTAGAGAAAACAGGAGGAGCTTGCTACAATGCTCTGTGTGGCAAGAA
TGGATGCTTTCTCTCTGCTATTTTAATCCTAAGAATTCAGATGAGCAAAAGATAACAGAAATGGTATACGCCATATTCAGAATCCTGCTT
TACCATGCAGTCAAATATGAGTGGGGTGGCTGGCGTGTATGGGTAGACACTTTATCAATCACTCATTCAAAGGTCACTTTTGAAATACAC
AAAGAAAACCTTGCCAATATATTTAGGGAACAGCAAGGAAAAGTTGATGAAGAAATAGGGCTGTGTTCTTCAACTTCAGTTCAAGCAGCC
TCTGGCATTAGAAGGGATATTAATGTTTCAGTAGGATCCCAGCAACCAGATACGAAGGATTCTCCTGTCTGTCCTCATTTCACCACAAAT
GGTAATGAAAATTCAAGTATAGAGAAGACAAGTTCACTAGAATCTGCATCTAATATTGAACTGCAAACTACTAATACATCTTATGAAGAA
ATGAAAGCTGAGCAAGAAAATCAGGAGTTACCAGATGAAGGCACTTTGGAAGAAACACTGACAAATGAGACAAGGAATGCAGATGATTTA
GAAGTATCTTCTGACATAATAGAAGCTGTGGCTATTTCCTCTAATTCTTTTATAACAACTGGCAAAGATTCAATGACTGTCAGTGAAGTA
ACTGCTTCTATAAGTTCTCCTTCAGAAGAGGATGCCTCAGAGATGCCAGAATTCTTGGATAAATCTATAGTAGAGGAAGAGGAAGATGAT
GATTATGTGGAACTGAAAGTAGAAGGCAGTCCTACTGAGGAAGCTAATCTACCCACAGAGCTCCAAGATAACAGTTTGTCTCCAGCTGCA
TCTGAAGCCGGTGAAAAACTGGACATGTTTGGTAATGATGACAAATTAATATTTCAAGAAGGAAAACCTGTTACTGAAAAGCAAACTGAT
ACTGAAACTCAAGATTCTAAAGATTCTGGAATTCAGACTATGACAGCATCAGGGTCTTCAGCTATGTCACCAGAAACTACTGTTTCCCAA
ATAGCTGTAGAATCAGACCTTGGTCAGATGCTGGAGGAAGGGAAGAAAGCAACTAACCTCACTAGAGAAACCAAATTAATTAATGATTGT
CATGGTAGTGTCTCTGAGGCTTCTTCTGAGCAAAAGATTGCGAAGTTGGATGTTTCCAATGTTGCTACAGATACTGAGAGGCTGGAGTTG
AAGGCCAGTCCCAACGTGGAAGCACCTCAACCTCATCGACATGTGCTTGAGATATCAAGGCAACATGAGCAGCCAGGGCAAGGAATAGCA
CCAGATGCAGTTAATGGACAAAGGAGGGATTCCAGATCTACTGTGTTTCGTATTCCTGAGTTCAACTGGTCTCAGATGCATCAACGTTTG
CTCACTGATCTATTATTTTCAATAGAAACAGATATACAGATGTGGAGAAGCCATTCAACAAAGACAGTTATGGACTTCGTGAATAGCAGT
GATAATGTCATCTTTGTACACAACACAATTCATCTCATCTCTCAAGTGATGGACAATATGGTCATGGCTTGTGGGGGTATACTGCCATTG
CTTTCAGCTGCTACATCGGCTACACATGAACTGGAAAATATTGAACCTACTCAAGGCCTTTCAATAGAAGCCTCTGTGACATTTTTGCAG
AGGCTAATTAGCCTTGTGGATGTGCTTATATTTGCAAGTTCTCTTGGCTTTACTGAAATTGAAGCTGAAAAAAGTATGTCATCTGGAGGA
ATTTTGCGGCAGTGTCTCCGACTAGTTTGTGCAGTCGCAGTAAGGAATTGCTTGGAGTGTCAACAGCATTCACAACTGAAAACTAGGGGA
GATAAAGCCTTGAAACCAATGCATAGCCTTATTCCTTTAGGGAAATCTGCAGCGAAGAGCCCAGTGGACATTGTGACTGGCGGTATATCT
CCAGTAAGAGATCTTGACAGGCTTCTACAGGACATGGATATTAATCGGCTTAGGGCAGTTGTTTTCAGAGACATAGAGGATAGCAAACAA
GCTCAATTTTTAGCCTTGGCAGTAGTATACTTTATCTCTGTTCTTATGGTCTCCAAGTACAGAGACATTTTGGAACCCCAAAATGAAAGG
CATAGCCAGTCATGTACAGAAACTGGCAGTGAAAATGAGAATGTATCACTCTCTGAAATCACACCAGCAGCATTCAGCACTTTAACTACG
GCATCAGTGGAAGAATCTGAAAGCACATCATCTGCTCGAAGGAGGGACTCAGGCATTGGGGAAGAAACAGCCACTGGTTTAGGAAGCCAT
GTGGAAGTAACTCCTCACACAGCACCTCCTGGTGTCAGTGCAGGCCCAGATGCAATCAGCGAGGTGCTATCTACTCTTTCTTTAGAAGTC
AATAAGTCTCCGGAAACCAAAAATGATAGAGGAAATGACTTGGACACTAAGGCTACACCGTCAGTTTCAGTTTCAAAAAACGTCAATGTG
AAAGACATTCTCCGAAGCTTGGTTAACATACCAGCAGATGGAGTCACAGTGGATCCTGCCCTTCTGCCACCAGCCTGCCTTGGAGCCCTT
GGTGATCTATCTGTGGAACAACCCGTGCAGTTCAGATCTTTTGACAGAAGTGTCATTGTTGCAGCAAAAAAGTCAGCAGTCTCACCTTCC
ACCTTTAATACAAGCATACCTACCAATGCTGTCAGTGTGGTTTCCTCAGTAGATTCAGCCCAAGCCTCAGATATGGGAGGAGAATCACCA
GGCAGTAGATCATCTAATGCAAAATTGCCCTCAGTTCCAACAGTTGATTCAGTTTCACAAGATCCGGTTTCAAATATGAGTATTACAGAG
AGGCTTGAACACGCTTTGGAAAAGGCAGCTCCTCTCCTTCGTGAGATTTTTGTGGATTTTGCACCTTTTCTTTCTCGGACACTTTTGGGT
AGCCATGGACAAGAACTGCTTATAGAAGGAACAAGTCTGGTTTGCATGAAGTCGAGTAGTTCAGTTGTGGAATTGGTTATGCTACTGTGT
TCTCAGGAGTGGCAAAATTCTATTCAGAAGAATGCAGGCCTTGCTTTTATCGAACTTGTCAATGAAGGAAGGTTGCTTAGCCAGACAATG
AAGGATCATCTAGTAAGAGTAGCAAATGAAGCTGAATTTATCCTGAGCAGGCAGAGAGCAGAAGATATTCACAGACATGCGGAATTTGAG
TCACTGTGTGCCCAGTATTCTGCAGACAAACGAGAAGATGAGAAGATGTGTGATCATTTGATAAGAGCAGCAAAATATCGTGACCACGTG
ACAGCAACTCAACTAATCCAGAAAATTATCAACATTCTCACAGACAAGCATGGAGCCTGGGGAAATTCTGCAGTGAGTCGTCCTCTTGAG
TTCTGGCGCCTTGACTACTGGGAAGATGACTTGCGGCGCCGGCGACGATTTGTGCGTAACCCTCTAGGATCGACACATCCTGAAGCGACA
CTAAAAACAGCCGTGGAACATGCCACAGATGAAGATATCCTTGCTAAAGGAAAACAGTCCATCAGGAGTCAGGCTTTAGGAAATCAGAAC
TCAGAAAACGAGATCCTCCTGGAAGGCGATGATGATACTCTGTCATCCGTGGATGAGAAAGATTTAGAGAATCTTGCCGGTCCTGTTAGC
CTGAGCACACCAGCTCAGCTTGTGGCCCCCTCTGTTGTAGTAAAGGGCACTCTTTCTGTCACCTCCTCCGAACTCTATTTTGAGGTGGAT
GAAGAGGATCCTAACTTCAAAAAAATCGACCCCAAGATCTTGGCATATACAGAAGGGCTGCATGGAAAATGGCTGTTCACAGAGATACGA
TCAATCTTTTCTCGTCGTTATCTTTTGCAAAATACAGCCCTGGAGATCTTTATGGCAAACAGAGTTGCTGTGATGTTCAACTTCCCAGAC
CCTGCAACAGTAAAGAAAGTGGTTAACTATCTACCTCGTGTTGGCGTTGGAACAAGTTTTGGATTGCCTCAAACCAGACGTATTTCATTA
GCTAGTCCACGTCAGCTTTTTAAGGCTTCTAATATGACCCAGCGATGGCAACACAGAGAGATATCTAATTTTGAGTACTTGATGTTTCTC
AACACGATAGCAGGACGGAGTTATAATGACTTAAATCAGTATCCAGTGTTTCCTTGGGTCATCACTAATTATGAATCAGAAGAACTGGAT
CTTACCTTGCCCACCAACTTCAGAGATTTGTCCAAGCCAATAGGAGCTCTGAACCCAAAAAGAGCAGCATTCTTCGCTGAGCGTTATGAA
TCATGGGAAGATGATCAAGTTCCAAAGTTTCACTATGGTACTCATTACTCAACTGCAAGTTTTGTTCTTGCATGGCTGCTAAGAATAGAA
CCCTTTACAACTTATTTCCTAAATTTGCAAGGAGGCAAATTTGATCATGCAGATCGAACTTTTTCATCAATTTCCAGAGCTTGGCGAAAC
AGTCAGCGTGATACCTCTGATATTAAGGAGTTGATCCCTGAATTTTATTATCTCCCTGAGATGTTTGTCAACTTCAATAATTATAATCTT
GGAGTGATGGATGATGGGACAGTAGTGTCTGATGTCGAACTTCCTCCTTGGGCCAAAACCTCAGAAGAATTTGTTCACATAAACAGATTG
GCCCTGGAGAGTGAATTTGTTTCCTGCCAGCTTCACCAATGGATTGATCTCATTTTTGGCTATAAACAGCAAGGACCAGAAGCTGTCCGA
GCCCTCAATGTGTTCTATTACTTGACCTATGAAGGAGCTGTCAATCTGAATTCAATAACTGATCCTGTGTTGAGAGAGGCTGTTGAAGCT
CAAATCCGAAGTTTTGGACAGACTCCTTCTCAACTACTCATAGAGCCCCATCCTCCCAGAGGTTCTGCCATGCAAGTGAGTCCATTGATG
TTCACAGACAAAGCCCAGCAGGATGTTATCATGGTCCTCAAGTTTCCCTCCAACTCCCCTGTTACTCACGTGGCAGCCAACACCCAGCCT
GGTTTGGCAACTCCCGCTGTGATCACAGTCACTGCTAACAGGTTATTTGCGGTGAACAAATGGCACAACCTTCCTGCTCATCAAGGTGCT
GTACAAGACCAGCCATACCAGCTGCCAGTGGAAATCGATCCTCTCATAGCCAGCAATACAGGAATGCACAGGAGGCAAATCACTGACCTT
TTAGACCAAAGTATTCAAGTGCATTCCCAGTGCTTTGTCATCACTTCAGACAACCGCTATATTCTCGTCTGTGGCTTCTGGGATAAAAGT
TTCAGAGTCTATTCTACAGACACAGGAAGATTGATCCAAGTGGTGTTTGGCCATTGGGATGTCGTCACTTGCCTTGCTCGTTCTGAGTCA
TATATTGGGGGAAATTGCTACATTCTCTCAGGGTCACGTGATGCAACTCTTTTGCTGTGGTATTGGAATGGAAAATGCAGTGGGATTGGA
GATAACCCAGGCAGTGAGACTGCTGCTCCTCGGGCCATTTTGACCGGCCATGACTATGAGGTCACATGTGCTGCGGTGTGTGCGGAGCTA
GGCCTGGTGTTGAGTGGTTCACAAGAAGGACCATGTCTCATACATTCCATGAATGGAGACTTGTTGAGGACCTTGGAGGGTCCTGAAAAC
TGCCTGAAACCAAAACTCATTCAGGCTTCAAGAGAGGGTCATTGTGTCATATTCTATGAAAACGGCCTCTTCTGTACATTCAGTGTGAAT
GGAAAACTCCAGGCCACGATGGAAACAGATGATAACATAAGAGCCATCCAGCTGAGCCGAGATGGGCAGTACCTGCTCACAGGAGGAGAC
AGAGGAGTGGTCGTGGTCCGGCAGGTGTCGGACCTCAAGCAGCTCTTTGCCTATCCAGGATGTGACGCTGGAATCCGGGCCATGGCGCTG
TCTTACGACCAGAGGTGCATCATTTCTGGCATGGCTTCAGGAAGCATTGTGCTATTTTACAACGACTTTAACCGGTGGCATCATGAATAC
CAAACCCGCTACTGATGGTGACAGCTGTACATCAACTCTGCCCCTAGGATGAGCAGAAGTACCTGGAGCATCATTCTCTTCTACCACATC
TGAATGTAACTTAAATTTGCTCAAAGAAGCAAAATATTTTTTAAAGTTATTAATAATTGCTATTTTTGTAGTCTTTGCTTGACTTTTTTG
GGGGGGATTAGCAAAGCAGAAAACTGGCTGCTGGGTTCTGTAGTTTTAAAAAATCTATATTTTTAGTCATAATGAGAAGTCTATTTTCAC
CAATTATGGAAACATACAGTGGAGCAAGTAAACCACTTATTCCAGCTATAATATTATGAAGAACATTTCCCATGCATCTACAAGCTTGAG
AAATAGGATTTTCACAGTGGGGAAGTGGGTTACAATATTGGAATAGGAAAATTTGATGCTGTAATTTGGGTCCTGTATTTTTCCAAACAA
CTGTGCTTCTTCAGCACTAATATTTCTGGGATTTAAATAGTAATGTTTAAATTATGGTAAATGTAATTTAAAACATCTCAATTAAGTCTG
TCTATCAATATTGTTCTTCAAGCATGTTTTAGACCTAGAAAAGTATGGTTTGGGGGAGGCTATTTTATTGTGTGGTTAGCACAAGGAATC
TAATTTATAGCAAGTGTGAAATAGTTACCATTTTTTCCTGATCTGTCATCTTCATAGCACAACAAAACGAAATGATGGAAATGCTCTTGA
GCTCACAACATTTGTTTTTCTTTTAAAGTAAATGCAAGTACCAAAGCTCACTACTGCGGTTTGCCTGTGCCTGGACAATGAGGCGGAGCC
ACTGTTGTTTTGTTGGGGCACCCCCTTCCCTCCCCGGGTTTGCAAATAGAGGCTACCGGGTGCTGTATTCAGCAACACCTGTTTTACTAT
TTGTTATTAAACTATCATCTCCACCTTCCTTTTGATTAGCAATTTGTACTAAGAAACGAAACAATGTTATTTGGTGGTGTATAATTCTAC
TTTTCTAGTAGATTACTGTGTGGAATTCTGTGAAAAATATTTGAGAAAAGGCCTGTATTGCATAAATAAATTCTTTGTATGTTGTGAACT
TTGATCTCTATTTCTCTTGCAACAGACTTCAAGTGGTCCCTCTTTTTTTCCTACACACTCAGCTCTTCTCTAAAAGCAAGGATTTGGAAT
GAACAATTCAGTTTGACAGAAAAAGCTGAATAAAATGGCATCTGTAATTGAATTGTTGGAAATGCCTTTTTTGCTCCTAAATTTTAAACA

>3879_3879_4_ALDH2-LRBA_ALDH2_chr12_112237867_ENST00000416293_LRBA_chr4_151793907_ENST00000535741_length(amino acids)=2552AA_BP=422
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKALETLDNGKPYVISYLV
DLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKE
AGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQ
CCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQ
DGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVCVIYKLLASKSEGIRVQALKAMGYFLKHL
APKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRR
AFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYHAVKYEWGGWRVWVDTLSITHSKVTFEIHKE
NLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMK
AEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDY
VELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIA
VESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKASPNVEAPQPHRHVLEISRQHEQPGQGIAPD
AVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLS
AATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKTRGDK
ALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHS
QSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVEVTPHTAPPGVSAGPDAISEVLSTLSLEVNK
SPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGDLSVEQPVQFRSFDRSVIVAAKKSAVSPSTF
NTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTVDSVSQDPVSNMSITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSH
GQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESL
CAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLK
TAVEHATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEE
DPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLAS
PRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESW
EDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGV
MDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQI
RSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQ
DQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYI
GGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCL
KPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSY

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Top

Fusion Gene PPI Analysis for ALDH2-LRBA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ALDH2-LRBA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneALDH2P05091DB00536GuanidineInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00536GuanidineInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00822DisulfiramInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00822DisulfiramInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00157NADHSmall moleculeApproved|Nutraceutical
HgeneALDH2P05091DB00157NADHSmall moleculeApproved|Nutraceutical

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Related Diseases for ALDH2-LRBA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALDH2C0001973Alcoholic Intoxication, Chronic7CTD_human;PSYGENET
HgeneALDH2C0085762Alcohol abuse7CTD_human;PSYGENET
HgeneALDH2C0001969Alcoholic Intoxication5PSYGENET
HgeneALDH2C0393756Hangover from alcohol4PSYGENET
HgeneALDH2C0236664Alcohol-Related Disorders3PSYGENET
HgeneALDH2C0001956Alcohol Use Disorder2CTD_human
HgeneALDH2C0004096Asthma2CTD_human
HgeneALDH2C0005586Bipolar Disorder2PSYGENET
HgeneALDH2C0279626Squamous cell carcinoma of esophagus2CTD_human
HgeneALDH2C0009402Colorectal Carcinoma1CTD_human
HgeneALDH2C0009404Colorectal Neoplasms1CTD_human
HgeneALDH2C0014859Esophageal Neoplasms1CTD_human
HgeneALDH2C0016382Flushing1CTD_human
HgeneALDH2C0016689Freckles1CTD_human
HgeneALDH2C0021364Male infertility1CTD_human
HgeneALDH2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneALDH2C0025209Melanosis1CTD_human
HgeneALDH2C0025218Chloasma1CTD_human
HgeneALDH2C0028796Dermatitis, Occupational1CTD_human
HgeneALDH2C0032927Precancerous Conditions1CTD_human
HgeneALDH2C0042373Vascular Diseases1CTD_human
HgeneALDH2C0086457Industrial Dermatosis1CTD_human
HgeneALDH2C0236970Alcohol-Induced Disorders1CTD_human
HgeneALDH2C0242973Ventricular Dysfunction1CTD_human
HgeneALDH2C0282313Condition, Preneoplastic1CTD_human
HgeneALDH2C0342257Complications of Diabetes Mellitus1CTD_human
HgeneALDH2C0349464Wernicke-Korsakoff Syndrome1PSYGENET
HgeneALDH2C0400966Non-alcoholic Fatty Liver Disease1CTD_human
HgeneALDH2C0520459Necrotizing Enterocolitis1CTD_human
HgeneALDH2C0546837Malignant neoplasm of esophagus1CTD_human
HgeneALDH2C0848676Subfertility, Male1CTD_human
HgeneALDH2C0917731Male sterility1CTD_human
HgeneALDH2C2674838ALCOHOL SENSITIVITY, ACUTE1CTD_human
HgeneALDH2C3241937Nonalcoholic Steatohepatitis1CTD_human
TgeneC3553512IMMUNODEFICIENCY, COMMON VARIABLE, 8, WITH AUTOIMMUNITY7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT