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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BPTF-NSF (FusionGDB2 ID:HG2186TG4905)

Fusion Gene Summary for BPTF-NSF

check button Fusion gene summary
Fusion gene informationFusion gene name: BPTF-NSF
Fusion gene ID: hg2186tg4905
HgeneTgene
Gene symbol

BPTF

NSF

Gene ID

2186

4905

Gene namebromodomain PHD finger transcription factorN-ethylmaleimide sensitive factor, vesicle fusing ATPase
SynonymsFAC1|FALZ|NEDDFL|NURF301SEC18|SKD2
Cytomap('BPTF')('NSF')

17q24.2

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionnucleosome-remodeling factor subunit BPTFbromodomain and PHD domain transcription factorbromodomain and PHD finger-containing transcription factorfetal Alz-50 clone 1 proteinfetal Alz-50 reactive clone 1fetal Alzheimer antigennucleosome remodeling fvesicle-fusing ATPaseN-ethylmaleimide-sensitive factor-like proteinN-ethylmaleimide-sensitive fusion proteinNEM-sensitive fusion proteinepididymis secretory sperm binding proteinvesicular-fusion protein NSF
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000306378, ENST00000321892, 
ENST00000335221, ENST00000424123, 
ENST00000577770, 
Fusion gene scores* DoF score27 X 21 X 13=737111 X 8 X 6=528
# samples 4212
** MAII scorelog2(42/7371*10)=-4.1333991254172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BPTF [Title/Abstract] AND NSF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBPTF(65822453)-NSF(44751779), # samples:1
Anticipated loss of major functional domain due to fusion event.BPTF-NSF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BPTF-NSF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BPTF-NSF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BPTF-NSF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBPTF

GO:0000122

negative regulation of transcription by RNA polymerase II

10727212

HgeneBPTF

GO:0006338

chromatin remodeling

14609955

TgeneNSF

GO:0001921

positive regulation of receptor recycling

15613468


check buttonFusion gene breakpoints across BPTF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NSF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TVBPTFchr17

65822453

+NSFchr17

44751779

+


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Fusion Gene ORF analysis for BPTF-NSF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000306378ENST00000225282BPTFchr17

65822453

+NSFchr17

44751779

+
In-frameENST00000306378ENST00000398238BPTFchr17

65822453

+NSFchr17

44751779

+
In-frameENST00000306378ENST00000575068BPTFchr17

65822453

+NSFchr17

44751779

+
In-frameENST00000321892ENST00000225282BPTFchr17

65822453

+NSFchr17

44751779

+
In-frameENST00000321892ENST00000398238BPTFchr17

65822453

+NSFchr17

44751779

+
In-frameENST00000321892ENST00000575068BPTFchr17

65822453

+NSFchr17

44751779

+
In-frameENST00000335221ENST00000225282BPTFchr17

65822453

+NSFchr17

44751779

+
In-frameENST00000335221ENST00000398238BPTFchr17

65822453

+NSFchr17

44751779

+
In-frameENST00000335221ENST00000575068BPTFchr17

65822453

+NSFchr17

44751779

+
In-frameENST00000424123ENST00000225282BPTFchr17

65822453

+NSFchr17

44751779

+
In-frameENST00000424123ENST00000398238BPTFchr17

65822453

+NSFchr17

44751779

+
In-frameENST00000424123ENST00000575068BPTFchr17

65822453

+NSFchr17

44751779

+
intron-3CDSENST00000577770ENST00000225282BPTFchr17

65822453

+NSFchr17

44751779

+
intron-3CDSENST00000577770ENST00000398238BPTFchr17

65822453

+NSFchr17

44751779

+
intron-3CDSENST00000577770ENST00000575068BPTFchr17

65822453

+NSFchr17

44751779

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000335221BPTFchr1765822453+ENST00000398238NSFchr1744751779+3805674612163700
ENST00000335221BPTFchr1765822453+ENST00000225282NSFchr1744751779+2665674612145694
ENST00000335221BPTFchr1765822453+ENST00000575068NSFchr1744751779+2400674612163700
ENST00000321892BPTFchr1765822453+ENST00000398238NSFchr1744751779+3805674612163700
ENST00000321892BPTFchr1765822453+ENST00000225282NSFchr1744751779+2665674612145694
ENST00000321892BPTFchr1765822453+ENST00000575068NSFchr1744751779+2400674612163700
ENST00000306378BPTFchr1765822453+ENST00000398238NSFchr1744751779+3804673602162700
ENST00000306378BPTFchr1765822453+ENST00000225282NSFchr1744751779+2664673602144694
ENST00000306378BPTFchr1765822453+ENST00000575068NSFchr1744751779+2399673602162700
ENST00000424123BPTFchr1765822453+ENST00000398238NSFchr1744751779+332719601685561
ENST00000424123BPTFchr1765822453+ENST00000225282NSFchr1744751779+218719601667555
ENST00000424123BPTFchr1765822453+ENST00000575068NSFchr1744751779+192219601685561

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000335221ENST00000398238BPTFchr1765822453+NSFchr1744751779+0.0010802450.9989197
ENST00000335221ENST00000225282BPTFchr1765822453+NSFchr1744751779+0.003717710.9962823
ENST00000335221ENST00000575068BPTFchr1765822453+NSFchr1744751779+0.004357030.995643
ENST00000321892ENST00000398238BPTFchr1765822453+NSFchr1744751779+0.0010802450.9989197
ENST00000321892ENST00000225282BPTFchr1765822453+NSFchr1744751779+0.003717710.9962823
ENST00000321892ENST00000575068BPTFchr1765822453+NSFchr1744751779+0.004357030.995643
ENST00000306378ENST00000398238BPTFchr1765822453+NSFchr1744751779+0.0010810310.998919
ENST00000306378ENST00000225282BPTFchr1765822453+NSFchr1744751779+0.0037258060.99627423
ENST00000306378ENST00000575068BPTFchr1765822453+NSFchr1744751779+0.0043612950.9956388
ENST00000424123ENST00000398238BPTFchr1765822453+NSFchr1744751779+0.0005063060.9994937
ENST00000424123ENST00000225282BPTFchr1765822453+NSFchr1744751779+0.0014426570.9985574
ENST00000424123ENST00000575068BPTFchr1765822453+NSFchr1744751779+0.0016611110.9983388

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Fusion Genomic Features for BPTF-NSF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BPTFchr1765822453+NSFchr1744751779+5.17E-131
BPTFchr1765822453+NSFchr1744751779+5.17E-131

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BPTF-NSF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:65822453/chr17:44751779)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+128143_1802042921.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+128149_1852042921.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+130143_1802043047.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+130149_1852043047.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+130143_1802042904.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+130149_1852042904.0Compositional biasNote=Asp-rich
TgeneNSFchr17:65822453chr17:44751779ENST00000398238721505_510248745.0Nucleotide bindingATP
TgeneNSFchr17:65822453chr17:44751779ENST00000398238721545_552248745.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+1282022_20502042921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+1282706_27322042921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+128574_6042042921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+128978_10072042921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+1302022_20502043047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+1302706_27322043047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+130574_6042043047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+130978_10072043047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+1302022_20502042904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+1302706_27322042904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+130574_6042042904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+130978_10072042904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+1281709_18032042921.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+1282338_23612042921.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+1282795_28172042921.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+1282848_28532042921.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+1301709_18032043047.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+1302338_23612043047.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+1302795_28172043047.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+1302848_28532043047.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+1301709_18032042904.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+1302338_23612042904.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+1302795_28172042904.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+1302848_28532042904.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+128240_3002042921.0DomainDDT
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+1282944_30142042921.0DomainBromo
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+130240_3002043047.0DomainDDT
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+1302944_30142043047.0DomainBromo
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+130240_3002042904.0DomainDDT
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+1302944_30142042904.0DomainBromo
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+1282867_29182042921.0Zinc fingerPHD-type 2
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+128390_4372042921.0Zinc fingerPHD-type 1
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+1302867_29182043047.0Zinc fingerPHD-type 2
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+130390_4372043047.0Zinc fingerPHD-type 1
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+1302867_29182042904.0Zinc fingerPHD-type 2
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+130390_4372042904.0Zinc fingerPHD-type 1


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Fusion Gene Sequence for BPTF-NSF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10094_10094_1_BPTF-NSF_BPTF_chr17_65822453_ENST00000306378_NSF_chr17_44751779_ENST00000225282_length(transcript)=2664nt_BP=673nt
GCCCCCCCTGCGCCCGCCCCTCCCCCTTCGCTTTCCTTCTCCCCCCGCCTCGGCTCCGACATGAGGGGCCGGCGGGGCAGGCCGCCCAAG
CAGCCCGCGGCTCCCGCTGCGGAGCGCTGCGCCCCGGCCCCGCCGCCACCGCCGCCGCCGCCCACGTCCGGACCCATCGGGGGGCTCCGC
TCGCGGCACCGCGGCAGCAGCCGGGGCAGGTGGGCCGCCGCCCAGGCTGAGGTGGCGCCCAAGACGCGGCTGAGCTCGCCCAGGGGGGGC
AGCAGTAGCCGGAGGAAGCCGCCGCCGCCGCCGCCGGCCCCCCCCAGCACCAGCGCCCCGGGCCGGGGGGGGCGAGGAGGCGGGGGCGGC
AGGACGGGGGGCGGGGGCGGCGGCGGCCACCTGGCCCGGACCACCGCGGCCCGGAGGGCCGTCAACAAAGTGGTGTACGATGACCACGAG
AGCGAGGAGGAGGAGGAAGAGGAGGACATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGAC
GACGAGGAGGATGAGATGGAAGAGGACGACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCACG
GAAAGCAGCTTCAGGAGCCATAGTACCTACAGCAGCACTCCAGGTTGTAAACATGTTAAAGGCATCCTGTTATATGGACCCCCAGGTTGT
GGTAAGACTCTCTTGGCTCGACAGATTGGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGCCAGAAATCCTTAACAAATAT
GTGGGAGAATCAGAGGCTAACATTCGCAAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTGGTTTGCACATC
ATCATCTTTGATGAAATTGATGCCATCTGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTTG
CTGTCCAAAATTGATGGCGTGGAGCAGCTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATCTGATAGATGAGGCTCTTCTT
AGACCTGGAAGACTGGAAGTTAAAATGGAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTCACATCCACACAGCAAGAATG
AGAGGGCATCAGTTACTCTCTGCTGATGTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCTGAATTGGAGGGTCTG
GTGCGAGCAGCCCAGTCCACTGCTATGAATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCTGCAA
GTGACGAGAGGAGACTTCCTTGCTTCTTTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTATG
AACGGTATCATCAAATGGGGTGACCCAGTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGACTAAGAACAGTGACCGCACA
CCATTGGTCAGCGTGCTTCTGGAAGGCCCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGAGGAATCCAACTTCCCGTTC
ATCAAGATCTGTTCTCCTGATAAAATGATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCGTACAAA
TCCCAGCTCAGTTGTGTGGTTGTGGATGACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACAG
GCTCTTCTCGTTTTACTGAAAAAGGCACCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCAAAGATGTCCTTCAGGAG
ATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGGC
AACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAATGCTGATC
GAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCGTAATAGCCCCCTTGATTT
TGATTGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACTGTCTTACTCAAGA
TACTGGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCTTATGCATACTGAG
ATAGCTTAGTGTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGCAGGCTAAAGTGATTCCTTCTTGCTCAG
TCCCTCTGGGTGGGAACCATCCAGTACTTGTGGACACTACACGTTTCAACCTCTCTACTAGCACCATCACCCTTGAAAACTCTCAGTCAG
TGTCATGAATGTTGCATGACAACAGTTGGCCGATTAGAAGGCAGACTTTCTACATGCAAATCTGGCTTAGTAAATCGAGGTGTGGGCCAG
AGATCCTCTGACAGCTGTCCTGAGCTAACACTAAAAGTCACTGGGTATTTGGTT

>10094_10094_1_BPTF-NSF_BPTF_chr17_65822453_ENST00000306378_NSF_chr17_44751779_ENST00000225282_length(amino acids)=694AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE
QLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGA

--------------------------------------------------------------
>10094_10094_2_BPTF-NSF_BPTF_chr17_65822453_ENST00000306378_NSF_chr17_44751779_ENST00000398238_length(transcript)=3804nt_BP=673nt
GCCCCCCCTGCGCCCGCCCCTCCCCCTTCGCTTTCCTTCTCCCCCCGCCTCGGCTCCGACATGAGGGGCCGGCGGGGCAGGCCGCCCAAG
CAGCCCGCGGCTCCCGCTGCGGAGCGCTGCGCCCCGGCCCCGCCGCCACCGCCGCCGCCGCCCACGTCCGGACCCATCGGGGGGCTCCGC
TCGCGGCACCGCGGCAGCAGCCGGGGCAGGTGGGCCGCCGCCCAGGCTGAGGTGGCGCCCAAGACGCGGCTGAGCTCGCCCAGGGGGGGC
AGCAGTAGCCGGAGGAAGCCGCCGCCGCCGCCGCCGGCCCCCCCCAGCACCAGCGCCCCGGGCCGGGGGGGGCGAGGAGGCGGGGGCGGC
AGGACGGGGGGCGGGGGCGGCGGCGGCCACCTGGCCCGGACCACCGCGGCCCGGAGGGCCGTCAACAAAGTGGTGTACGATGACCACGAG
AGCGAGGAGGAGGAGGAAGAGGAGGACATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGAC
GACGAGGAGGATGAGATGGAAGAGGACGACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCACG
GAAAGCAGCTTCAGGAGCCATAGTACCTACAGCAGCACTCCAGGTTGTAAACATGTTAAAGGCATCCTGTTATATGGACCCCCAGGTTGT
GGTAAGACTCTCTTGGCTCGACAGATTGGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGCCAGAAATCCTTAACAAATAT
GTGGGAGAATCAGAGGCTAACATTCGCAAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTGGTTTGCACATC
ATCATCTTTGATGAAATTGATGCCATCTGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTTG
CTGTCCAAAATTGATGGCGTGGAGCAGCTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATCTGATAGATGAGGCTCTTCTT
AGACCTGGAAGACTGGAAGTTAAAATGGAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTCACATCCACACAGCAAGAATG
AGAGGGCATCAGTTACTCTCTGCTGATGTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCTGAATTGGAGGGTCTG
GTGCGAGCAGCCCAGTCCACTGCTATGAATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCTGCAA
GTGACGAGAGGAGACTTCCTTGCTTCTTTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTATG
AACGGTATCATCAAATGGGGTGACCCAGTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGACTAAGAACAGTGACCGCACA
CCATTGGTCAGCGTGCTTCTGGAAGGCCCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGAGGAATCCAACTTCCCGTTC
ATCAAGATCTGTTCTCCTGATAAAATGATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCGTACAAA
TCCCAGCTCAGTTGTGTGGTTGTGGATGACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACAG
GCTCTTCTCGTTTTACTGAAAAAGGCACCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCAAAGATGTCCTTCAGGAG
ATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGGC
AACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAATGCTGATC
GAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCTAGCCCCCTTGATTTTGAT
TGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACTGTCTTACTCAAGATACT
GGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCTTATGCATACTGAGATAG
CTTAGTGTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGCAGGCTAAAGTGATTCCTTCTTGCTCAGTCCC
TCTGGGTGGGAACCATCCAGTACTTGTGGACACTACACGTTTCAACCTCTCTACTAGCACCATCACCCTTGAAAACTCTCAGTCAGTGTC
ATGAATGTTGCATGACAACAGTTGGCCGATTAGAAGGCAGACTTTCTACATGCAAATCTGGCTTAGTAAATCGAGGTGTGGGCCAGAGAT
CCTCTGACAGCTGTCCTGAGCTAACACTAAAAGTCACTGGGTATTTGGTTAAAGGTCTCCCACAAGACTGGTATTCTCTTTGCCTGAAGA
AACAAGGCATTGAATCTCTAAAATGCTGTTCTCAATCATTGTCAGAGATGTTTTCAAGTTGCAGTCAGAAGATCTTTCTTAATAGAAAGT
CAGATGACTACCGTGTTGGTTGTGACTTCCCCTTAAGTATAACTAATTTGCTCTGTGGTAAGAGATATGCTCATTATTACCACTTAGAAG
ATGTTGTTAAAAACATGTGAAAGATAGGTATGGAAAAAGCATACACCCCCAAACAGAAAGGAGTTATTAAAGTAATTTACAAACCTCTCA
GCACTAATTAGTGTCCAACTCCAAGTGGGTCAATTCCTTAGTATAATATTAAGGCTTACTAGTATCACTGCTTTTTCCTTAGCTTAATGA
CTTACTTAGAATTTATCCTTTATTTTAAATGATCTGTACTATCTAGTGTCTAAAACACTATTCTCCAGAAAAATCAATCATTTTCTAGCC
CTCTCCCTCAGTCCTTTATTGTCCATTCCAATACATTGAACACATTTCCTTTACCCTCCACACACTTCTTCCAAAAGGAAGCACCCGTTG
AGTCCTTTTGAGGGTGATTTGTCTTACAACTGACTGACTTAGCAGGAATTTAATTAGGTCATATTTGGTGATGAGACTTATGGAGTGTGC
CTCTCTCTCCCAACTGCTGCTTAAAATGCAAGGACAAGCAATTAGAAGCCATCCTAAGGTGCTTACCTCACACGCCACCCATGAGGCTTG
TGGCCACAGTGGCACTTGGGTGTGGCTCCTCTGTTATTTGTCCTCATGTGAGAAAGCAGATCATCTCCAAATCTTGCCATTTGTATACTT
TTGGTGGAGACTTGGATGTCATATCTTCTTTGTTTTGGGTTTTCTTCCCTAGCTTATTTTGTGGCTTTTAAAGAAGTGGATTGTATTGTG
AGATCCTGTGATTCCTGGTGGCCAGTATCCTGGATTCCTCTAAGATCTTGCCTCTTTCCTCCTCATGAAAGCAGCACACATTGTGTTAAC
TTATGTCTCTTGTTAAATGAGCTTAATGTCTTTGTGTTTTGTCCAAAACTGTATTGAAAAAATATTGTTTAATGCAAATGAAGGAATGCA
ATAAAGAGTAAATATACTTGAAAA

>10094_10094_2_BPTF-NSF_BPTF_chr17_65822453_ENST00000306378_NSF_chr17_44751779_ENST00000398238_length(amino acids)=700AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE
QLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGASPLDFD

--------------------------------------------------------------
>10094_10094_3_BPTF-NSF_BPTF_chr17_65822453_ENST00000306378_NSF_chr17_44751779_ENST00000575068_length(transcript)=2399nt_BP=673nt
GCCCCCCCTGCGCCCGCCCCTCCCCCTTCGCTTTCCTTCTCCCCCCGCCTCGGCTCCGACATGAGGGGCCGGCGGGGCAGGCCGCCCAAG
CAGCCCGCGGCTCCCGCTGCGGAGCGCTGCGCCCCGGCCCCGCCGCCACCGCCGCCGCCGCCCACGTCCGGACCCATCGGGGGGCTCCGC
TCGCGGCACCGCGGCAGCAGCCGGGGCAGGTGGGCCGCCGCCCAGGCTGAGGTGGCGCCCAAGACGCGGCTGAGCTCGCCCAGGGGGGGC
AGCAGTAGCCGGAGGAAGCCGCCGCCGCCGCCGCCGGCCCCCCCCAGCACCAGCGCCCCGGGCCGGGGGGGGCGAGGAGGCGGGGGCGGC
AGGACGGGGGGCGGGGGCGGCGGCGGCCACCTGGCCCGGACCACCGCGGCCCGGAGGGCCGTCAACAAAGTGGTGTACGATGACCACGAG
AGCGAGGAGGAGGAGGAAGAGGAGGACATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGAC
GACGAGGAGGATGAGATGGAAGAGGACGACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCACG
GAAAGCAGCTTCAGGAGCCATAGTACCTACAGCAGCACTCCAGGTTGTAAACATGTTAAAGGCATCCTGTTATATGGACCCCCAGGTTGT
GGTAAGACTCTCTTGGCTCGACAGATTGGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGCCAGAAATCCTTAACAAATAT
GTGGGAGAATCAGAGGCTAACATTCGCAAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTGGTTTGCACATC
ATCATCTTTGATGAAATTGATGCCATCTGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTTG
CTGTCCAAAATTGATGGCGTGGAGCAGCTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATCTGATAGATGAGGCTCTTCTT
AGACCTGGAAGACTGGAAGTTAAAATGGAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTCACATCCACACAGCAAGAATG
AGAGGGCATCAGTTACTCTCTGCTGATGTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCTGAATTGGAGGGTCTG
GTGCGAGCAGCCCAGTCCACTGCTATGAATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCTGCAA
GTGACGAGAGGAGACTTCCTTGCTTCTTTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTATG
AACGGTATCATCAAATGGGGTGACCCAGTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGACTAAGAACAGTGACCGCACA
CCATTGGTCAGCGTGCTTCTGGAAGGCCCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGAGGAATCCAACTTCCCGTTC
ATCAAGATCTGTTCTCCTGATAAAATGATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCGTACAAA
TCCCAGCTCAGTTGTGTGGTTGTGGATGACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACAG
GCTCTTCTCGTTTTACTGAAAAAGGCACCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCAAAGATGTCCTTCAGGAG
ATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGGC
AACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAATGCTGATC
GAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCTAGCCCCCTTGATTTTGAT
TGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACTGTCTTACTCAAGATACT
GGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCTTATGCATACTGAGATAG
CTTAGTGTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGC

>10094_10094_3_BPTF-NSF_BPTF_chr17_65822453_ENST00000306378_NSF_chr17_44751779_ENST00000575068_length(amino acids)=700AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE
QLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGASPLDFD

--------------------------------------------------------------
>10094_10094_4_BPTF-NSF_BPTF_chr17_65822453_ENST00000321892_NSF_chr17_44751779_ENST00000225282_length(transcript)=2665nt_BP=674nt
CGCCCCCCCTGCGCCCGCCCCTCCCCCTTCGCTTTCCTTCTCCCCCCGCCTCGGCTCCGACATGAGGGGCCGGCGGGGCAGGCCGCCCAA
GCAGCCCGCGGCTCCCGCTGCGGAGCGCTGCGCCCCGGCCCCGCCGCCACCGCCGCCGCCGCCCACGTCCGGACCCATCGGGGGGCTCCG
CTCGCGGCACCGCGGCAGCAGCCGGGGCAGGTGGGCCGCCGCCCAGGCTGAGGTGGCGCCCAAGACGCGGCTGAGCTCGCCCAGGGGGGG
CAGCAGTAGCCGGAGGAAGCCGCCGCCGCCGCCGCCGGCCCCCCCCAGCACCAGCGCCCCGGGCCGGGGGGGGCGAGGAGGCGGGGGCGG
CAGGACGGGGGGCGGGGGCGGCGGCGGCCACCTGGCCCGGACCACCGCGGCCCGGAGGGCCGTCAACAAAGTGGTGTACGATGACCACGA
GAGCGAGGAGGAGGAGGAAGAGGAGGACATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGA
CGACGAGGAGGATGAGATGGAAGAGGACGACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCAC
GGAAAGCAGCTTCAGGAGCCATAGTACCTACAGCAGCACTCCAGGTTGTAAACATGTTAAAGGCATCCTGTTATATGGACCCCCAGGTTG
TGGTAAGACTCTCTTGGCTCGACAGATTGGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGCCAGAAATCCTTAACAAATA
TGTGGGAGAATCAGAGGCTAACATTCGCAAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTGGTTTGCACAT
CATCATCTTTGATGAAATTGATGCCATCTGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTT
GCTGTCCAAAATTGATGGCGTGGAGCAGCTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATCTGATAGATGAGGCTCTTCT
TAGACCTGGAAGACTGGAAGTTAAAATGGAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTCACATCCACACAGCAAGAAT
GAGAGGGCATCAGTTACTCTCTGCTGATGTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCTGAATTGGAGGGTCT
GGTGCGAGCAGCCCAGTCCACTGCTATGAATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCTGCA
AGTGACGAGAGGAGACTTCCTTGCTTCTTTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTAT
GAACGGTATCATCAAATGGGGTGACCCAGTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGACTAAGAACAGTGACCGCAC
ACCATTGGTCAGCGTGCTTCTGGAAGGCCCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGAGGAATCCAACTTCCCGTT
CATCAAGATCTGTTCTCCTGATAAAATGATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCGTACAA
ATCCCAGCTCAGTTGTGTGGTTGTGGATGACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACA
GGCTCTTCTCGTTTTACTGAAAAAGGCACCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCAAAGATGTCCTTCAGGA
GATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGG
CAACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAATGCTGAT
CGAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCGTAATAGCCCCCTTGATT
TTGATTGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACTGTCTTACTCAAG
ATACTGGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCTTATGCATACTGA
GATAGCTTAGTGTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGCAGGCTAAAGTGATTCCTTCTTGCTCA
GTCCCTCTGGGTGGGAACCATCCAGTACTTGTGGACACTACACGTTTCAACCTCTCTACTAGCACCATCACCCTTGAAAACTCTCAGTCA
GTGTCATGAATGTTGCATGACAACAGTTGGCCGATTAGAAGGCAGACTTTCTACATGCAAATCTGGCTTAGTAAATCGAGGTGTGGGCCA
GAGATCCTCTGACAGCTGTCCTGAGCTAACACTAAAAGTCACTGGGTATTTGGTT

>10094_10094_4_BPTF-NSF_BPTF_chr17_65822453_ENST00000321892_NSF_chr17_44751779_ENST00000225282_length(amino acids)=694AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE
QLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGA

--------------------------------------------------------------
>10094_10094_5_BPTF-NSF_BPTF_chr17_65822453_ENST00000321892_NSF_chr17_44751779_ENST00000398238_length(transcript)=3805nt_BP=674nt
CGCCCCCCCTGCGCCCGCCCCTCCCCCTTCGCTTTCCTTCTCCCCCCGCCTCGGCTCCGACATGAGGGGCCGGCGGGGCAGGCCGCCCAA
GCAGCCCGCGGCTCCCGCTGCGGAGCGCTGCGCCCCGGCCCCGCCGCCACCGCCGCCGCCGCCCACGTCCGGACCCATCGGGGGGCTCCG
CTCGCGGCACCGCGGCAGCAGCCGGGGCAGGTGGGCCGCCGCCCAGGCTGAGGTGGCGCCCAAGACGCGGCTGAGCTCGCCCAGGGGGGG
CAGCAGTAGCCGGAGGAAGCCGCCGCCGCCGCCGCCGGCCCCCCCCAGCACCAGCGCCCCGGGCCGGGGGGGGCGAGGAGGCGGGGGCGG
CAGGACGGGGGGCGGGGGCGGCGGCGGCCACCTGGCCCGGACCACCGCGGCCCGGAGGGCCGTCAACAAAGTGGTGTACGATGACCACGA
GAGCGAGGAGGAGGAGGAAGAGGAGGACATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGA
CGACGAGGAGGATGAGATGGAAGAGGACGACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCAC
GGAAAGCAGCTTCAGGAGCCATAGTACCTACAGCAGCACTCCAGGTTGTAAACATGTTAAAGGCATCCTGTTATATGGACCCCCAGGTTG
TGGTAAGACTCTCTTGGCTCGACAGATTGGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGCCAGAAATCCTTAACAAATA
TGTGGGAGAATCAGAGGCTAACATTCGCAAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTGGTTTGCACAT
CATCATCTTTGATGAAATTGATGCCATCTGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTT
GCTGTCCAAAATTGATGGCGTGGAGCAGCTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATCTGATAGATGAGGCTCTTCT
TAGACCTGGAAGACTGGAAGTTAAAATGGAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTCACATCCACACAGCAAGAAT
GAGAGGGCATCAGTTACTCTCTGCTGATGTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCTGAATTGGAGGGTCT
GGTGCGAGCAGCCCAGTCCACTGCTATGAATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCTGCA
AGTGACGAGAGGAGACTTCCTTGCTTCTTTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTAT
GAACGGTATCATCAAATGGGGTGACCCAGTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGACTAAGAACAGTGACCGCAC
ACCATTGGTCAGCGTGCTTCTGGAAGGCCCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGAGGAATCCAACTTCCCGTT
CATCAAGATCTGTTCTCCTGATAAAATGATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCGTACAA
ATCCCAGCTCAGTTGTGTGGTTGTGGATGACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACA
GGCTCTTCTCGTTTTACTGAAAAAGGCACCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCAAAGATGTCCTTCAGGA
GATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGG
CAACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAATGCTGAT
CGAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCTAGCCCCCTTGATTTTGA
TTGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACTGTCTTACTCAAGATAC
TGGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCTTATGCATACTGAGATA
GCTTAGTGTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGCAGGCTAAAGTGATTCCTTCTTGCTCAGTCC
CTCTGGGTGGGAACCATCCAGTACTTGTGGACACTACACGTTTCAACCTCTCTACTAGCACCATCACCCTTGAAAACTCTCAGTCAGTGT
CATGAATGTTGCATGACAACAGTTGGCCGATTAGAAGGCAGACTTTCTACATGCAAATCTGGCTTAGTAAATCGAGGTGTGGGCCAGAGA
TCCTCTGACAGCTGTCCTGAGCTAACACTAAAAGTCACTGGGTATTTGGTTAAAGGTCTCCCACAAGACTGGTATTCTCTTTGCCTGAAG
AAACAAGGCATTGAATCTCTAAAATGCTGTTCTCAATCATTGTCAGAGATGTTTTCAAGTTGCAGTCAGAAGATCTTTCTTAATAGAAAG
TCAGATGACTACCGTGTTGGTTGTGACTTCCCCTTAAGTATAACTAATTTGCTCTGTGGTAAGAGATATGCTCATTATTACCACTTAGAA
GATGTTGTTAAAAACATGTGAAAGATAGGTATGGAAAAAGCATACACCCCCAAACAGAAAGGAGTTATTAAAGTAATTTACAAACCTCTC
AGCACTAATTAGTGTCCAACTCCAAGTGGGTCAATTCCTTAGTATAATATTAAGGCTTACTAGTATCACTGCTTTTTCCTTAGCTTAATG
ACTTACTTAGAATTTATCCTTTATTTTAAATGATCTGTACTATCTAGTGTCTAAAACACTATTCTCCAGAAAAATCAATCATTTTCTAGC
CCTCTCCCTCAGTCCTTTATTGTCCATTCCAATACATTGAACACATTTCCTTTACCCTCCACACACTTCTTCCAAAAGGAAGCACCCGTT
GAGTCCTTTTGAGGGTGATTTGTCTTACAACTGACTGACTTAGCAGGAATTTAATTAGGTCATATTTGGTGATGAGACTTATGGAGTGTG
CCTCTCTCTCCCAACTGCTGCTTAAAATGCAAGGACAAGCAATTAGAAGCCATCCTAAGGTGCTTACCTCACACGCCACCCATGAGGCTT
GTGGCCACAGTGGCACTTGGGTGTGGCTCCTCTGTTATTTGTCCTCATGTGAGAAAGCAGATCATCTCCAAATCTTGCCATTTGTATACT
TTTGGTGGAGACTTGGATGTCATATCTTCTTTGTTTTGGGTTTTCTTCCCTAGCTTATTTTGTGGCTTTTAAAGAAGTGGATTGTATTGT
GAGATCCTGTGATTCCTGGTGGCCAGTATCCTGGATTCCTCTAAGATCTTGCCTCTTTCCTCCTCATGAAAGCAGCACACATTGTGTTAA
CTTATGTCTCTTGTTAAATGAGCTTAATGTCTTTGTGTTTTGTCCAAAACTGTATTGAAAAAATATTGTTTAATGCAAATGAAGGAATGC
AATAAAGAGTAAATATACTTGAAAA

>10094_10094_5_BPTF-NSF_BPTF_chr17_65822453_ENST00000321892_NSF_chr17_44751779_ENST00000398238_length(amino acids)=700AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE
QLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGASPLDFD

--------------------------------------------------------------
>10094_10094_6_BPTF-NSF_BPTF_chr17_65822453_ENST00000321892_NSF_chr17_44751779_ENST00000575068_length(transcript)=2400nt_BP=674nt
CGCCCCCCCTGCGCCCGCCCCTCCCCCTTCGCTTTCCTTCTCCCCCCGCCTCGGCTCCGACATGAGGGGCCGGCGGGGCAGGCCGCCCAA
GCAGCCCGCGGCTCCCGCTGCGGAGCGCTGCGCCCCGGCCCCGCCGCCACCGCCGCCGCCGCCCACGTCCGGACCCATCGGGGGGCTCCG
CTCGCGGCACCGCGGCAGCAGCCGGGGCAGGTGGGCCGCCGCCCAGGCTGAGGTGGCGCCCAAGACGCGGCTGAGCTCGCCCAGGGGGGG
CAGCAGTAGCCGGAGGAAGCCGCCGCCGCCGCCGCCGGCCCCCCCCAGCACCAGCGCCCCGGGCCGGGGGGGGCGAGGAGGCGGGGGCGG
CAGGACGGGGGGCGGGGGCGGCGGCGGCCACCTGGCCCGGACCACCGCGGCCCGGAGGGCCGTCAACAAAGTGGTGTACGATGACCACGA
GAGCGAGGAGGAGGAGGAAGAGGAGGACATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGA
CGACGAGGAGGATGAGATGGAAGAGGACGACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCAC
GGAAAGCAGCTTCAGGAGCCATAGTACCTACAGCAGCACTCCAGGTTGTAAACATGTTAAAGGCATCCTGTTATATGGACCCCCAGGTTG
TGGTAAGACTCTCTTGGCTCGACAGATTGGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGCCAGAAATCCTTAACAAATA
TGTGGGAGAATCAGAGGCTAACATTCGCAAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTGGTTTGCACAT
CATCATCTTTGATGAAATTGATGCCATCTGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTT
GCTGTCCAAAATTGATGGCGTGGAGCAGCTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATCTGATAGATGAGGCTCTTCT
TAGACCTGGAAGACTGGAAGTTAAAATGGAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTCACATCCACACAGCAAGAAT
GAGAGGGCATCAGTTACTCTCTGCTGATGTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCTGAATTGGAGGGTCT
GGTGCGAGCAGCCCAGTCCACTGCTATGAATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCTGCA
AGTGACGAGAGGAGACTTCCTTGCTTCTTTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTAT
GAACGGTATCATCAAATGGGGTGACCCAGTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGACTAAGAACAGTGACCGCAC
ACCATTGGTCAGCGTGCTTCTGGAAGGCCCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGAGGAATCCAACTTCCCGTT
CATCAAGATCTGTTCTCCTGATAAAATGATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCGTACAA
ATCCCAGCTCAGTTGTGTGGTTGTGGATGACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACA
GGCTCTTCTCGTTTTACTGAAAAAGGCACCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCAAAGATGTCCTTCAGGA
GATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGG
CAACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAATGCTGAT
CGAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCTAGCCCCCTTGATTTTGA
TTGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACTGTCTTACTCAAGATAC
TGGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCTTATGCATACTGAGATA
GCTTAGTGTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGC

>10094_10094_6_BPTF-NSF_BPTF_chr17_65822453_ENST00000321892_NSF_chr17_44751779_ENST00000575068_length(amino acids)=700AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE
QLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGASPLDFD

--------------------------------------------------------------
>10094_10094_7_BPTF-NSF_BPTF_chr17_65822453_ENST00000335221_NSF_chr17_44751779_ENST00000225282_length(transcript)=2665nt_BP=674nt
CGCCCCCCCTGCGCCCGCCCCTCCCCCTTCGCTTTCCTTCTCCCCCCGCCTCGGCTCCGACATGAGGGGCCGGCGGGGCAGGCCGCCCAA
GCAGCCCGCGGCTCCCGCTGCGGAGCGCTGCGCCCCGGCCCCGCCGCCACCGCCGCCGCCGCCCACGTCCGGACCCATCGGGGGGCTCCG
CTCGCGGCACCGCGGCAGCAGCCGGGGCAGGTGGGCCGCCGCCCAGGCTGAGGTGGCGCCCAAGACGCGGCTGAGCTCGCCCAGGGGGGG
CAGCAGTAGCCGGAGGAAGCCGCCGCCGCCGCCGCCGGCCCCCCCCAGCACCAGCGCCCCGGGCCGGGGGGGGCGAGGAGGCGGGGGCGG
CAGGACGGGGGGCGGGGGCGGCGGCGGCCACCTGGCCCGGACCACCGCGGCCCGGAGGGCCGTCAACAAAGTGGTGTACGATGACCACGA
GAGCGAGGAGGAGGAGGAAGAGGAGGACATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGA
CGACGAGGAGGATGAGATGGAAGAGGACGACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCAC
GGAAAGCAGCTTCAGGAGCCATAGTACCTACAGCAGCACTCCAGGTTGTAAACATGTTAAAGGCATCCTGTTATATGGACCCCCAGGTTG
TGGTAAGACTCTCTTGGCTCGACAGATTGGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGCCAGAAATCCTTAACAAATA
TGTGGGAGAATCAGAGGCTAACATTCGCAAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTGGTTTGCACAT
CATCATCTTTGATGAAATTGATGCCATCTGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTT
GCTGTCCAAAATTGATGGCGTGGAGCAGCTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATCTGATAGATGAGGCTCTTCT
TAGACCTGGAAGACTGGAAGTTAAAATGGAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTCACATCCACACAGCAAGAAT
GAGAGGGCATCAGTTACTCTCTGCTGATGTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCTGAATTGGAGGGTCT
GGTGCGAGCAGCCCAGTCCACTGCTATGAATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCTGCA
AGTGACGAGAGGAGACTTCCTTGCTTCTTTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTAT
GAACGGTATCATCAAATGGGGTGACCCAGTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGACTAAGAACAGTGACCGCAC
ACCATTGGTCAGCGTGCTTCTGGAAGGCCCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGAGGAATCCAACTTCCCGTT
CATCAAGATCTGTTCTCCTGATAAAATGATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCGTACAA
ATCCCAGCTCAGTTGTGTGGTTGTGGATGACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACA
GGCTCTTCTCGTTTTACTGAAAAAGGCACCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCAAAGATGTCCTTCAGGA
GATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGG
CAACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAATGCTGAT
CGAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCGTAATAGCCCCCTTGATT
TTGATTGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACTGTCTTACTCAAG
ATACTGGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCTTATGCATACTGA
GATAGCTTAGTGTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGCAGGCTAAAGTGATTCCTTCTTGCTCA
GTCCCTCTGGGTGGGAACCATCCAGTACTTGTGGACACTACACGTTTCAACCTCTCTACTAGCACCATCACCCTTGAAAACTCTCAGTCA
GTGTCATGAATGTTGCATGACAACAGTTGGCCGATTAGAAGGCAGACTTTCTACATGCAAATCTGGCTTAGTAAATCGAGGTGTGGGCCA
GAGATCCTCTGACAGCTGTCCTGAGCTAACACTAAAAGTCACTGGGTATTTGGTT

>10094_10094_7_BPTF-NSF_BPTF_chr17_65822453_ENST00000335221_NSF_chr17_44751779_ENST00000225282_length(amino acids)=694AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE
QLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGA

--------------------------------------------------------------
>10094_10094_8_BPTF-NSF_BPTF_chr17_65822453_ENST00000335221_NSF_chr17_44751779_ENST00000398238_length(transcript)=3805nt_BP=674nt
CGCCCCCCCTGCGCCCGCCCCTCCCCCTTCGCTTTCCTTCTCCCCCCGCCTCGGCTCCGACATGAGGGGCCGGCGGGGCAGGCCGCCCAA
GCAGCCCGCGGCTCCCGCTGCGGAGCGCTGCGCCCCGGCCCCGCCGCCACCGCCGCCGCCGCCCACGTCCGGACCCATCGGGGGGCTCCG
CTCGCGGCACCGCGGCAGCAGCCGGGGCAGGTGGGCCGCCGCCCAGGCTGAGGTGGCGCCCAAGACGCGGCTGAGCTCGCCCAGGGGGGG
CAGCAGTAGCCGGAGGAAGCCGCCGCCGCCGCCGCCGGCCCCCCCCAGCACCAGCGCCCCGGGCCGGGGGGGGCGAGGAGGCGGGGGCGG
CAGGACGGGGGGCGGGGGCGGCGGCGGCCACCTGGCCCGGACCACCGCGGCCCGGAGGGCCGTCAACAAAGTGGTGTACGATGACCACGA
GAGCGAGGAGGAGGAGGAAGAGGAGGACATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGA
CGACGAGGAGGATGAGATGGAAGAGGACGACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCAC
GGAAAGCAGCTTCAGGAGCCATAGTACCTACAGCAGCACTCCAGGTTGTAAACATGTTAAAGGCATCCTGTTATATGGACCCCCAGGTTG
TGGTAAGACTCTCTTGGCTCGACAGATTGGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGCCAGAAATCCTTAACAAATA
TGTGGGAGAATCAGAGGCTAACATTCGCAAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTGGTTTGCACAT
CATCATCTTTGATGAAATTGATGCCATCTGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTT
GCTGTCCAAAATTGATGGCGTGGAGCAGCTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATCTGATAGATGAGGCTCTTCT
TAGACCTGGAAGACTGGAAGTTAAAATGGAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTCACATCCACACAGCAAGAAT
GAGAGGGCATCAGTTACTCTCTGCTGATGTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCTGAATTGGAGGGTCT
GGTGCGAGCAGCCCAGTCCACTGCTATGAATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCTGCA
AGTGACGAGAGGAGACTTCCTTGCTTCTTTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTAT
GAACGGTATCATCAAATGGGGTGACCCAGTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGACTAAGAACAGTGACCGCAC
ACCATTGGTCAGCGTGCTTCTGGAAGGCCCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGAGGAATCCAACTTCCCGTT
CATCAAGATCTGTTCTCCTGATAAAATGATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCGTACAA
ATCCCAGCTCAGTTGTGTGGTTGTGGATGACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACA
GGCTCTTCTCGTTTTACTGAAAAAGGCACCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCAAAGATGTCCTTCAGGA
GATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGG
CAACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAATGCTGAT
CGAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCTAGCCCCCTTGATTTTGA
TTGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACTGTCTTACTCAAGATAC
TGGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCTTATGCATACTGAGATA
GCTTAGTGTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGCAGGCTAAAGTGATTCCTTCTTGCTCAGTCC
CTCTGGGTGGGAACCATCCAGTACTTGTGGACACTACACGTTTCAACCTCTCTACTAGCACCATCACCCTTGAAAACTCTCAGTCAGTGT
CATGAATGTTGCATGACAACAGTTGGCCGATTAGAAGGCAGACTTTCTACATGCAAATCTGGCTTAGTAAATCGAGGTGTGGGCCAGAGA
TCCTCTGACAGCTGTCCTGAGCTAACACTAAAAGTCACTGGGTATTTGGTTAAAGGTCTCCCACAAGACTGGTATTCTCTTTGCCTGAAG
AAACAAGGCATTGAATCTCTAAAATGCTGTTCTCAATCATTGTCAGAGATGTTTTCAAGTTGCAGTCAGAAGATCTTTCTTAATAGAAAG
TCAGATGACTACCGTGTTGGTTGTGACTTCCCCTTAAGTATAACTAATTTGCTCTGTGGTAAGAGATATGCTCATTATTACCACTTAGAA
GATGTTGTTAAAAACATGTGAAAGATAGGTATGGAAAAAGCATACACCCCCAAACAGAAAGGAGTTATTAAAGTAATTTACAAACCTCTC
AGCACTAATTAGTGTCCAACTCCAAGTGGGTCAATTCCTTAGTATAATATTAAGGCTTACTAGTATCACTGCTTTTTCCTTAGCTTAATG
ACTTACTTAGAATTTATCCTTTATTTTAAATGATCTGTACTATCTAGTGTCTAAAACACTATTCTCCAGAAAAATCAATCATTTTCTAGC
CCTCTCCCTCAGTCCTTTATTGTCCATTCCAATACATTGAACACATTTCCTTTACCCTCCACACACTTCTTCCAAAAGGAAGCACCCGTT
GAGTCCTTTTGAGGGTGATTTGTCTTACAACTGACTGACTTAGCAGGAATTTAATTAGGTCATATTTGGTGATGAGACTTATGGAGTGTG
CCTCTCTCTCCCAACTGCTGCTTAAAATGCAAGGACAAGCAATTAGAAGCCATCCTAAGGTGCTTACCTCACACGCCACCCATGAGGCTT
GTGGCCACAGTGGCACTTGGGTGTGGCTCCTCTGTTATTTGTCCTCATGTGAGAAAGCAGATCATCTCCAAATCTTGCCATTTGTATACT
TTTGGTGGAGACTTGGATGTCATATCTTCTTTGTTTTGGGTTTTCTTCCCTAGCTTATTTTGTGGCTTTTAAAGAAGTGGATTGTATTGT
GAGATCCTGTGATTCCTGGTGGCCAGTATCCTGGATTCCTCTAAGATCTTGCCTCTTTCCTCCTCATGAAAGCAGCACACATTGTGTTAA
CTTATGTCTCTTGTTAAATGAGCTTAATGTCTTTGTGTTTTGTCCAAAACTGTATTGAAAAAATATTGTTTAATGCAAATGAAGGAATGC
AATAAAGAGTAAATATACTTGAAAA

>10094_10094_8_BPTF-NSF_BPTF_chr17_65822453_ENST00000335221_NSF_chr17_44751779_ENST00000398238_length(amino acids)=700AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE
QLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGASPLDFD

--------------------------------------------------------------
>10094_10094_9_BPTF-NSF_BPTF_chr17_65822453_ENST00000335221_NSF_chr17_44751779_ENST00000575068_length(transcript)=2400nt_BP=674nt
CGCCCCCCCTGCGCCCGCCCCTCCCCCTTCGCTTTCCTTCTCCCCCCGCCTCGGCTCCGACATGAGGGGCCGGCGGGGCAGGCCGCCCAA
GCAGCCCGCGGCTCCCGCTGCGGAGCGCTGCGCCCCGGCCCCGCCGCCACCGCCGCCGCCGCCCACGTCCGGACCCATCGGGGGGCTCCG
CTCGCGGCACCGCGGCAGCAGCCGGGGCAGGTGGGCCGCCGCCCAGGCTGAGGTGGCGCCCAAGACGCGGCTGAGCTCGCCCAGGGGGGG
CAGCAGTAGCCGGAGGAAGCCGCCGCCGCCGCCGCCGGCCCCCCCCAGCACCAGCGCCCCGGGCCGGGGGGGGCGAGGAGGCGGGGGCGG
CAGGACGGGGGGCGGGGGCGGCGGCGGCCACCTGGCCCGGACCACCGCGGCCCGGAGGGCCGTCAACAAAGTGGTGTACGATGACCACGA
GAGCGAGGAGGAGGAGGAAGAGGAGGACATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGA
CGACGAGGAGGATGAGATGGAAGAGGACGACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCAC
GGAAAGCAGCTTCAGGAGCCATAGTACCTACAGCAGCACTCCAGGTTGTAAACATGTTAAAGGCATCCTGTTATATGGACCCCCAGGTTG
TGGTAAGACTCTCTTGGCTCGACAGATTGGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGCCAGAAATCCTTAACAAATA
TGTGGGAGAATCAGAGGCTAACATTCGCAAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTGGTTTGCACAT
CATCATCTTTGATGAAATTGATGCCATCTGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTT
GCTGTCCAAAATTGATGGCGTGGAGCAGCTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATCTGATAGATGAGGCTCTTCT
TAGACCTGGAAGACTGGAAGTTAAAATGGAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTCACATCCACACAGCAAGAAT
GAGAGGGCATCAGTTACTCTCTGCTGATGTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCTGAATTGGAGGGTCT
GGTGCGAGCAGCCCAGTCCACTGCTATGAATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCTGCA
AGTGACGAGAGGAGACTTCCTTGCTTCTTTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTAT
GAACGGTATCATCAAATGGGGTGACCCAGTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGACTAAGAACAGTGACCGCAC
ACCATTGGTCAGCGTGCTTCTGGAAGGCCCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGAGGAATCCAACTTCCCGTT
CATCAAGATCTGTTCTCCTGATAAAATGATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCGTACAA
ATCCCAGCTCAGTTGTGTGGTTGTGGATGACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACA
GGCTCTTCTCGTTTTACTGAAAAAGGCACCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCAAAGATGTCCTTCAGGA
GATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGG
CAACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAATGCTGAT
CGAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCTAGCCCCCTTGATTTTGA
TTGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACTGTCTTACTCAAGATAC
TGGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCTTATGCATACTGAGATA
GCTTAGTGTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGC

>10094_10094_9_BPTF-NSF_BPTF_chr17_65822453_ENST00000335221_NSF_chr17_44751779_ENST00000575068_length(amino acids)=700AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE
QLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGASPLDFD

--------------------------------------------------------------
>10094_10094_10_BPTF-NSF_BPTF_chr17_65822453_ENST00000424123_NSF_chr17_44751779_ENST00000225282_length(transcript)=2187nt_BP=196nt
ATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGACGACGAGGAGGATGAGATGGAAGAGGAC
GACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCACGGAAAGCAGCTTCAGGAGCCATAGTACC
TACAGCAGCACTCCAGGTTGTAAACATGTTAAAGGCATCCTGTTATATGGACCCCCAGGTTGTGGTAAGACTCTCTTGGCTCGACAGATT
GGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGCCAGAAATCCTTAACAAATATGTGGGAGAATCAGAGGCTAACATTCGC
AAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTGGTTTGCACATCATCATCTTTGATGAAATTGATGCCATC
TGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTTGCTGTCCAAAATTGATGGCGTGGAGCAG
CTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATCTGATAGATGAGGCTCTTCTTAGACCTGGAAGACTGGAAGTTAAAATG
GAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTCACATCCACACAGCAAGAATGAGAGGGCATCAGTTACTCTCTGCTGAT
GTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCTGAATTGGAGGGTCTGGTGCGAGCAGCCCAGTCCACTGCTATG
AATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCTGCAAGTGACGAGAGGAGACTTCCTTGCTTCT
TTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTATGAACGGTATCATCAAATGGGGTGACCCA
GTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGACTAAGAACAGTGACCGCACACCATTGGTCAGCGTGCTTCTGGAAGGC
CCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGAGGAATCCAACTTCCCGTTCATCAAGATCTGTTCTCCTGATAAAATG
ATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCGTACAAATCCCAGCTCAGTTGTGTGGTTGTGGAT
GACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACAGGCTCTTCTCGTTTTACTGAAAAAGGCA
CCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCAAAGATGTCCTTCAGGAGATGGAAATGCTTAACGCTTTCAGCACC
ACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGGCAACTTCAAGGATAAGGAACGCACCACA
ATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAATGCTGATCGAGATGTCCCTACAGATGGATCCTGAA
TACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCGTAATAGCCCCCTTGATTTTGATTGAAAATGAACTATTTGAAACAC
ACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACTGTCTTACTCAAGATACTGGACTAAGTGGAACGTTCTCTAC
CTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCTTATGCATACTGAGATAGCTTAGTGTCTCGTGGAAGGTGTC
AATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGCAGGCTAAAGTGATTCCTTCTTGCTCAGTCCCTCTGGGTGGGAACCATCCAGTAC
TTGTGGACACTACACGTTTCAACCTCTCTACTAGCACCATCACCCTTGAAAACTCTCAGTCAGTGTCATGAATGTTGCATGACAACAGTT
GGCCGATTAGAAGGCAGACTTTCTACATGCAAATCTGGCTTAGTAAATCGAGGTGTGGGCCAGAGATCCTCTGACAGCTGTCCTGAGCTA
ACACTAAAAGTCACTGGGTATTTGGTT

>10094_10094_10_BPTF-NSF_BPTF_chr17_65822453_ENST00000424123_NSF_chr17_44751779_ENST00000225282_length(amino acids)=555AA_BP=65
MVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQI
GKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQ
LNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAM
NRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEG
PPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKA
PPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPE
YRVRKFLALLREEGA

--------------------------------------------------------------
>10094_10094_11_BPTF-NSF_BPTF_chr17_65822453_ENST00000424123_NSF_chr17_44751779_ENST00000398238_length(transcript)=3327nt_BP=196nt
ATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGACGACGAGGAGGATGAGATGGAAGAGGAC
GACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCACGGAAAGCAGCTTCAGGAGCCATAGTACC
TACAGCAGCACTCCAGGTTGTAAACATGTTAAAGGCATCCTGTTATATGGACCCCCAGGTTGTGGTAAGACTCTCTTGGCTCGACAGATT
GGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGCCAGAAATCCTTAACAAATATGTGGGAGAATCAGAGGCTAACATTCGC
AAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTGGTTTGCACATCATCATCTTTGATGAAATTGATGCCATC
TGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTTGCTGTCCAAAATTGATGGCGTGGAGCAG
CTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATCTGATAGATGAGGCTCTTCTTAGACCTGGAAGACTGGAAGTTAAAATG
GAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTCACATCCACACAGCAAGAATGAGAGGGCATCAGTTACTCTCTGCTGAT
GTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCTGAATTGGAGGGTCTGGTGCGAGCAGCCCAGTCCACTGCTATG
AATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCTGCAAGTGACGAGAGGAGACTTCCTTGCTTCT
TTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTATGAACGGTATCATCAAATGGGGTGACCCA
GTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGACTAAGAACAGTGACCGCACACCATTGGTCAGCGTGCTTCTGGAAGGC
CCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGAGGAATCCAACTTCCCGTTCATCAAGATCTGTTCTCCTGATAAAATG
ATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCGTACAAATCCCAGCTCAGTTGTGTGGTTGTGGAT
GACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACAGGCTCTTCTCGTTTTACTGAAAAAGGCA
CCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCAAAGATGTCCTTCAGGAGATGGAAATGCTTAACGCTTTCAGCACC
ACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGGCAACTTCAAGGATAAGGAACGCACCACA
ATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAATGCTGATCGAGATGTCCCTACAGATGGATCCTGAA
TACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCTAGCCCCCTTGATTTTGATTGAAAATGAACTATTTGAAACACACAG
TGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACTGTCTTACTCAAGATACTGGACTAAGTGGAACGTTCTCTACCTTC
AACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCTTATGCATACTGAGATAGCTTAGTGTCTCGTGGAAGGTGTCAATT
TGGTTTAGAATGCTGCGCTTACCTTCCCATGCAGGCTAAAGTGATTCCTTCTTGCTCAGTCCCTCTGGGTGGGAACCATCCAGTACTTGT
GGACACTACACGTTTCAACCTCTCTACTAGCACCATCACCCTTGAAAACTCTCAGTCAGTGTCATGAATGTTGCATGACAACAGTTGGCC
GATTAGAAGGCAGACTTTCTACATGCAAATCTGGCTTAGTAAATCGAGGTGTGGGCCAGAGATCCTCTGACAGCTGTCCTGAGCTAACAC
TAAAAGTCACTGGGTATTTGGTTAAAGGTCTCCCACAAGACTGGTATTCTCTTTGCCTGAAGAAACAAGGCATTGAATCTCTAAAATGCT
GTTCTCAATCATTGTCAGAGATGTTTTCAAGTTGCAGTCAGAAGATCTTTCTTAATAGAAAGTCAGATGACTACCGTGTTGGTTGTGACT
TCCCCTTAAGTATAACTAATTTGCTCTGTGGTAAGAGATATGCTCATTATTACCACTTAGAAGATGTTGTTAAAAACATGTGAAAGATAG
GTATGGAAAAAGCATACACCCCCAAACAGAAAGGAGTTATTAAAGTAATTTACAAACCTCTCAGCACTAATTAGTGTCCAACTCCAAGTG
GGTCAATTCCTTAGTATAATATTAAGGCTTACTAGTATCACTGCTTTTTCCTTAGCTTAATGACTTACTTAGAATTTATCCTTTATTTTA
AATGATCTGTACTATCTAGTGTCTAAAACACTATTCTCCAGAAAAATCAATCATTTTCTAGCCCTCTCCCTCAGTCCTTTATTGTCCATT
CCAATACATTGAACACATTTCCTTTACCCTCCACACACTTCTTCCAAAAGGAAGCACCCGTTGAGTCCTTTTGAGGGTGATTTGTCTTAC
AACTGACTGACTTAGCAGGAATTTAATTAGGTCATATTTGGTGATGAGACTTATGGAGTGTGCCTCTCTCTCCCAACTGCTGCTTAAAAT
GCAAGGACAAGCAATTAGAAGCCATCCTAAGGTGCTTACCTCACACGCCACCCATGAGGCTTGTGGCCACAGTGGCACTTGGGTGTGGCT
CCTCTGTTATTTGTCCTCATGTGAGAAAGCAGATCATCTCCAAATCTTGCCATTTGTATACTTTTGGTGGAGACTTGGATGTCATATCTT
CTTTGTTTTGGGTTTTCTTCCCTAGCTTATTTTGTGGCTTTTAAAGAAGTGGATTGTATTGTGAGATCCTGTGATTCCTGGTGGCCAGTA
TCCTGGATTCCTCTAAGATCTTGCCTCTTTCCTCCTCATGAAAGCAGCACACATTGTGTTAACTTATGTCTCTTGTTAAATGAGCTTAAT
GTCTTTGTGTTTTGTCCAAAACTGTATTGAAAAAATATTGTTTAATGCAAATGAAGGAATGCAATAAAGAGTAAATATACTTGAAAA

>10094_10094_11_BPTF-NSF_BPTF_chr17_65822453_ENST00000424123_NSF_chr17_44751779_ENST00000398238_length(amino acids)=561AA_BP=65
MVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQI
GKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQ
LNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAM
NRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEG
PPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKA
PPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPE
YRVRKFLALLREEGASPLDFD

--------------------------------------------------------------
>10094_10094_12_BPTF-NSF_BPTF_chr17_65822453_ENST00000424123_NSF_chr17_44751779_ENST00000575068_length(transcript)=1922nt_BP=196nt
ATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGACGACGAGGAGGATGAGATGGAAGAGGAC
GACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCACGGAAAGCAGCTTCAGGAGCCATAGTACC
TACAGCAGCACTCCAGGTTGTAAACATGTTAAAGGCATCCTGTTATATGGACCCCCAGGTTGTGGTAAGACTCTCTTGGCTCGACAGATT
GGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGCCAGAAATCCTTAACAAATATGTGGGAGAATCAGAGGCTAACATTCGC
AAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTGGTTTGCACATCATCATCTTTGATGAAATTGATGCCATC
TGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTTGCTGTCCAAAATTGATGGCGTGGAGCAG
CTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATCTGATAGATGAGGCTCTTCTTAGACCTGGAAGACTGGAAGTTAAAATG
GAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTCACATCCACACAGCAAGAATGAGAGGGCATCAGTTACTCTCTGCTGAT
GTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCTGAATTGGAGGGTCTGGTGCGAGCAGCCCAGTCCACTGCTATG
AATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCTGCAAGTGACGAGAGGAGACTTCCTTGCTTCT
TTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTATGAACGGTATCATCAAATGGGGTGACCCA
GTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGACTAAGAACAGTGACCGCACACCATTGGTCAGCGTGCTTCTGGAAGGC
CCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGAGGAATCCAACTTCCCGTTCATCAAGATCTGTTCTCCTGATAAAATG
ATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCGTACAAATCCCAGCTCAGTTGTGTGGTTGTGGAT
GACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACAGGCTCTTCTCGTTTTACTGAAAAAGGCA
CCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCAAAGATGTCCTTCAGGAGATGGAAATGCTTAACGCTTTCAGCACC
ACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGGCAACTTCAAGGATAAGGAACGCACCACA
ATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAATGCTGATCGAGATGTCCCTACAGATGGATCCTGAA
TACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCTAGCCCCCTTGATTTTGATTGAAAATGAACTATTTGAAACACACAG
TGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACTGTCTTACTCAAGATACTGGACTAAGTGGAACGTTCTCTACCTTC
AACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCTTATGCATACTGAGATAGCTTAGTGTCTCGTGGAAGGTGTCAATT
TGGTTTAGAATGCTGCGCTTACCTTCCCATGC

>10094_10094_12_BPTF-NSF_BPTF_chr17_65822453_ENST00000424123_NSF_chr17_44751779_ENST00000575068_length(amino acids)=561AA_BP=65
MVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQI
GKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQ
LNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAM
NRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEG
PPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKA
PPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPE
YRVRKFLALLREEGASPLDFD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BPTF-NSF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+128640_749204.333333333333342921.0KEAP1
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+130640_749204.333333333333343047.0KEAP1
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+130640_749204.333333333333342904.0KEAP1
HgeneBPTFchr17:65822453chr17:44751779ENST00000306378+128839_921204.333333333333342921.0MAZ
HgeneBPTFchr17:65822453chr17:44751779ENST00000321892+130839_921204.333333333333343047.0MAZ
HgeneBPTFchr17:65822453chr17:44751779ENST00000335221+130839_921204.333333333333342904.0MAZ


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BPTF-NSF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BPTF-NSF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBPTFC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneBPTFC0005695Bladder Neoplasm1CTD_human
HgeneBPTFC3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneBPTFC4540327NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND DISTAL LIMB ANOMALIES1GENOMICS_ENGLAND;UNIPROT
TgeneC0036572Seizures1GENOMICS_ENGLAND
TgeneC0557874Global developmental delay1GENOMICS_ENGLAND
TgeneC0600427Cocaine Dependence1PSYGENET
TgeneC1969156EEG with burst suppression1GENOMICS_ENGLAND
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND