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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:FBLN1-TCF7L2 (FusionGDB2 ID:HG2192TG6934) |
Fusion Gene Summary for FBLN1-TCF7L2 |
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Fusion gene information | Fusion gene name: FBLN1-TCF7L2 | Fusion gene ID: hg2192tg6934 | Hgene | Tgene | Gene symbol | FBLN1 | TCF7L2 | Gene ID | 2192 | 6934 |
Gene name | fibulin 1 | transcription factor 7 like 2 | |
Synonyms | FBLN|FIBL1 | TCF-4|TCF4 | |
Cytomap | ('FBLN1')('TCF7L2') 22q13.31 | 10q25.2-q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | fibulin-1 | transcription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box) | |
Modification date | 20200313 | 20200315 | |
UniProtAcc | . | Q9NQB0 | |
Ensembl transtripts involved in fusion gene | ENST00000476366, ENST00000262722, ENST00000327858, ENST00000340923, ENST00000348697, ENST00000402984, ENST00000442170, | ||
Fusion gene scores | * DoF score | 15 X 14 X 8=1680 | 12 X 11 X 10=1320 |
# samples | 17 | 17 | |
** MAII score | log2(17/1680*10)=-3.30485458152842 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/1320*10)=-2.95693127810811 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FBLN1 [Title/Abstract] AND TCF7L2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FBLN1(45946495)-TCF7L2(114724314), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | FBLN1-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. FBLN1-TCF7L2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. FBLN1-TCF7L2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. FBLN1-TCF7L2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FBLN1 | GO:0001933 | negative regulation of protein phosphorylation | 11792823 |
Hgene | FBLN1 | GO:0007162 | negative regulation of cell adhesion | 11792823 |
Hgene | FBLN1 | GO:0007229 | integrin-mediated signaling pathway | 11792823 |
Hgene | FBLN1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 11792823 |
Hgene | FBLN1 | GO:0072378 | blood coagulation, fibrin clot formation | 7642629 |
Hgene | FBLN1 | GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading | 11792823 |
Hgene | FBLN1 | GO:2000146 | negative regulation of cell motility | 11792823 |
Hgene | FBLN1 | GO:2000647 | negative regulation of stem cell proliferation | 11238726 |
Tgene | TCF7L2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12799378 |
Tgene | TCF7L2 | GO:0006357 | regulation of transcription by RNA polymerase II | 9727977 |
Tgene | TCF7L2 | GO:0032092 | positive regulation of protein binding | 12799378 |
Tgene | TCF7L2 | GO:0032350 | regulation of hormone metabolic process | 15525634 |
Tgene | TCF7L2 | GO:0042593 | glucose homeostasis | 15525634 |
Tgene | TCF7L2 | GO:0043433 | negative regulation of DNA-binding transcription factor activity | 12799378 |
Tgene | TCF7L2 | GO:0045444 | fat cell differentiation | 10937998 |
Tgene | TCF7L2 | GO:0045892 | negative regulation of transcription, DNA-templated | 12799378|15525634 |
Tgene | TCF7L2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9065401|19168596 |
Tgene | TCF7L2 | GO:0048625 | myoblast fate commitment | 10937998 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | 149N | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
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Fusion Gene ORF analysis for FBLN1-TCF7L2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000476366 | ENST00000355995 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-3CDS | ENST00000476366 | ENST00000534894 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-3CDS | ENST00000476366 | ENST00000536810 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-3CDS | ENST00000476366 | ENST00000543371 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-3CDS | ENST00000476366 | ENST00000545257 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-intron | ENST00000476366 | ENST00000349937 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-intron | ENST00000476366 | ENST00000352065 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-intron | ENST00000476366 | ENST00000355717 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-intron | ENST00000476366 | ENST00000369386 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-intron | ENST00000476366 | ENST00000369389 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-intron | ENST00000476366 | ENST00000369395 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-intron | ENST00000476366 | ENST00000369397 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-intron | ENST00000476366 | ENST00000466338 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-intron | ENST00000476366 | ENST00000538897 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
3UTR-intron | ENST00000476366 | ENST00000542695 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000262722 | ENST00000349937 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000262722 | ENST00000352065 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000262722 | ENST00000355717 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000262722 | ENST00000369386 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000262722 | ENST00000369389 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000262722 | ENST00000369395 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000262722 | ENST00000369397 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000262722 | ENST00000466338 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000262722 | ENST00000538897 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000262722 | ENST00000542695 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000327858 | ENST00000349937 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000327858 | ENST00000352065 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000327858 | ENST00000355717 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000327858 | ENST00000369386 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000327858 | ENST00000369389 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000327858 | ENST00000369395 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000327858 | ENST00000369397 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000327858 | ENST00000466338 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000327858 | ENST00000538897 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000327858 | ENST00000542695 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000340923 | ENST00000349937 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000340923 | ENST00000352065 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000340923 | ENST00000355717 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000340923 | ENST00000369386 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000340923 | ENST00000369389 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000340923 | ENST00000369395 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000340923 | ENST00000369397 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000340923 | ENST00000466338 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000340923 | ENST00000538897 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000340923 | ENST00000542695 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000348697 | ENST00000349937 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000348697 | ENST00000352065 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000348697 | ENST00000355717 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000348697 | ENST00000369386 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000348697 | ENST00000369389 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000348697 | ENST00000369395 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000348697 | ENST00000369397 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000348697 | ENST00000466338 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000348697 | ENST00000538897 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000348697 | ENST00000542695 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000402984 | ENST00000349937 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000402984 | ENST00000352065 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000402984 | ENST00000355717 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000402984 | ENST00000369386 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000402984 | ENST00000369389 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000402984 | ENST00000369395 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000402984 | ENST00000369397 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000402984 | ENST00000466338 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000402984 | ENST00000538897 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000402984 | ENST00000542695 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000442170 | ENST00000349937 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000442170 | ENST00000352065 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000442170 | ENST00000355717 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000442170 | ENST00000369386 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000442170 | ENST00000369389 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000442170 | ENST00000369395 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000442170 | ENST00000369397 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000442170 | ENST00000466338 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000442170 | ENST00000538897 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
5CDS-intron | ENST00000442170 | ENST00000542695 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000262722 | ENST00000355995 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000262722 | ENST00000534894 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000262722 | ENST00000536810 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000262722 | ENST00000543371 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000262722 | ENST00000545257 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000327858 | ENST00000355995 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000327858 | ENST00000534894 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000327858 | ENST00000536810 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000327858 | ENST00000543371 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000327858 | ENST00000545257 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000340923 | ENST00000355995 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000340923 | ENST00000534894 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000340923 | ENST00000536810 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000340923 | ENST00000543371 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000340923 | ENST00000545257 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000348697 | ENST00000355995 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000348697 | ENST00000534894 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000348697 | ENST00000536810 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000348697 | ENST00000543371 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000348697 | ENST00000545257 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000402984 | ENST00000355995 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000402984 | ENST00000534894 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000402984 | ENST00000536810 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000402984 | ENST00000543371 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000402984 | ENST00000545257 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000442170 | ENST00000355995 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000442170 | ENST00000534894 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000442170 | ENST00000536810 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000442170 | ENST00000543371 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
Frame-shift | ENST00000442170 | ENST00000545257 | FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for FBLN1-TCF7L2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + | 3.57E-06 | 0.9999964 |
FBLN1 | chr22 | 45946495 | + | TCF7L2 | chr10 | 114724314 | + | 3.57E-06 | 0.9999964 |
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Fusion Protein Features for FBLN1-TCF7L2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:45946495/:114724314) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | TCF7L2 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FBLN1-TCF7L2 |
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Fusion Gene PPI Analysis for FBLN1-TCF7L2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FBLN1-TCF7L2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FBLN1-TCF7L2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FBLN1 | C1842422 | Synpolydactyly 2 | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | FBLN1 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | FBLN1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | FBLN1 | C0269102 | Endometrioma | 1 | CTD_human |
Hgene | FBLN1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Tgene | C0036341 | Schizophrenia | 4 | PSYGENET | |
Tgene | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 3 | CTD_human | |
Tgene | C0009402 | Colorectal Carcinoma | 2 | CTD_human;UNIPROT | |
Tgene | C0009404 | Colorectal Neoplasms | 2 | CTD_human | |
Tgene | C0001418 | Adenocarcinoma | 1 | CTD_human | |
Tgene | C0005586 | Bipolar Disorder | 1 | PSYGENET | |
Tgene | C0007102 | Malignant tumor of colon | 1 | CTD_human | |
Tgene | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human | |
Tgene | C0009375 | Colonic Neoplasms | 1 | CTD_human | |
Tgene | C0010068 | Coronary heart disease | 1 | CTD_human | |
Tgene | C0020507 | Hyperplasia | 1 | CTD_human | |
Tgene | C0036337 | Schizoaffective Disorder | 1 | PSYGENET | |
Tgene | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human | |
Tgene | C0151744 | Myocardial Ischemia | 1 | CTD_human | |
Tgene | C0205641 | Adenocarcinoma, Basal Cell | 1 | CTD_human | |
Tgene | C0205642 | Adenocarcinoma, Oxyphilic | 1 | CTD_human | |
Tgene | C0205643 | Carcinoma, Cribriform | 1 | CTD_human | |
Tgene | C0205644 | Carcinoma, Granular Cell | 1 | CTD_human | |
Tgene | C0205645 | Adenocarcinoma, Tubular | 1 | CTD_human | |
Tgene | C0600519 | Ventricular Remodeling | 1 | CTD_human | |
Tgene | C0600520 | Left Ventricle Remodeling | 1 | CTD_human | |
Tgene | C1449563 | Cardiomyopathy, Familial Idiopathic | 1 | CTD_human | |
Tgene | C1535926 | Neurodevelopmental Disorders | 1 | CTD_human | |
Tgene | C2931456 | Prostate cancer, familial | 1 | CTD_human | |
Tgene | C3495559 | Juvenile arthritis | 1 | CTD_human | |
Tgene | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human | |
Tgene | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human | |
Tgene | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human | |
Tgene | C4722327 | PROSTATE CANCER, HEREDITARY, 1 | 1 | CTD_human |