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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CCNY-CREM (FusionGDB2 ID:HG219771TG1390)

Fusion Gene Summary for CCNY-CREM

Fusion gene summary

Fusion gene information	Fusion gene name: CCNY-CREM
	Fusion gene ID: hg219771tg1390
		Hgene	Tgene
	Gene symbol	CCNY	CREM
	Gene ID	219771	1390
	Gene name	cyclin Y	cAMP responsive element modulator
	Synonyms	C10orf9\|CBCP1\|CCNX\|CFP1	CREM-2\|ICER\|hCREM-2
	Cytomap	('CCNY')('CREM') 10p11.21	10p11.21
	Type of gene	protein-coding	protein-coding
	Description	cyclin-Ycyc-Ycyclin box protein 1cyclin fold protein 1cyclin-Xcyclin-box carrying protein 1	cAMP-responsive element modulatorCREM 2alpha-b proteinCREM 2beta-a proteincAMP response element modulatorinducible cAMP early repressor ICER
	Modification date	20200313	20200313
	UniProtAcc	.	Q03060
	Ensembl transtripts involved in fusion gene	ENST00000492478, ENST00000339497, ENST00000374704, ENST00000265375, ENST00000374706,
Fusion gene scores	* DoF score	23 X 14 X 12=3864	12 X 12 X 7=1008
	# samples	27	12
	** MAII score	log2(27/3864*10)=-3.83906378178494 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/1008*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CCNY [Title/Abstract] AND CREM [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CCNY(35626135)-CREM(35495823), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CCNY	GO:0000086	G2/M transition of mitotic cell cycle	20059949
Hgene	CCNY	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	19524571\|20059949
Hgene	CCNY	GO:0060828	regulation of canonical Wnt signaling pathway	20059949
Tgene	CREM	GO:0006355	regulation of transcription, DNA-templated	8206879

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	ERR315414	CCNY	chr10	35626135	+	CREM	chr10	35495823	+

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Fusion Gene ORF analysis for CCNY-CREM

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-5UTR	ENST00000492478	ENST00000344351	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-5UTR	ENST00000492478	ENST00000354759	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-5UTR	ENST00000492478	ENST00000374721	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-5UTR	ENST00000492478	ENST00000460270	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-5UTR	ENST00000492478	ENST00000474362	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-5UTR	ENST00000492478	ENST00000490511	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000333809	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000337656	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000342105	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000345491	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000348787	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000356917	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000361599	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000374726	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000374728	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000374734	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000395887	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000395895	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000429130	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000439705	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000463314	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000463960	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000468236	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000469949	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000473940	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000474931	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000479070	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000484283	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000487763	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000488328	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000488741	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000489321	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
3UTR-intron	ENST00000492478	ENST00000489388	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-5UTR	ENST00000339497	ENST00000344351	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-5UTR	ENST00000339497	ENST00000354759	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-5UTR	ENST00000339497	ENST00000374721	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-5UTR	ENST00000339497	ENST00000460270	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-5UTR	ENST00000339497	ENST00000474362	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-5UTR	ENST00000339497	ENST00000490511	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-5UTR	ENST00000374704	ENST00000344351	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-5UTR	ENST00000374704	ENST00000354759	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-5UTR	ENST00000374704	ENST00000374721	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-5UTR	ENST00000374704	ENST00000460270	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-5UTR	ENST00000374704	ENST00000474362	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-5UTR	ENST00000374704	ENST00000490511	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000333809	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000337656	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000342105	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000345491	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000348787	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000356917	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000361599	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000374726	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000374728	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000374734	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000395887	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000395895	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000429130	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000439705	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000463314	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000463960	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000468236	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000469949	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000473940	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000474931	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000479070	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000484283	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000487763	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000488328	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000488741	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000489321	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000339497	ENST00000489388	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000333809	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000337656	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000342105	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000345491	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000348787	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000356917	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000361599	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000374726	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000374728	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000374734	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000395887	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000395895	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000429130	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000439705	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000463314	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000463960	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000468236	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000469949	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000473940	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000474931	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000479070	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000484283	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000487763	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000488328	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000488741	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000489321	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5CDS-intron	ENST00000374704	ENST00000489388	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-5UTR	ENST00000265375	ENST00000344351	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-5UTR	ENST00000265375	ENST00000354759	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-5UTR	ENST00000265375	ENST00000374721	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-5UTR	ENST00000265375	ENST00000460270	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-5UTR	ENST00000265375	ENST00000474362	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-5UTR	ENST00000265375	ENST00000490511	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000333809	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000337656	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000342105	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000345491	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000348787	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000356917	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000361599	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000374726	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000374728	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000374734	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000395887	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000395895	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000429130	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000439705	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000463314	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000463960	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000468236	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000469949	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000473940	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000474931	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000479070	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000484283	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000487763	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000488328	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000488741	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000489321	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
5UTR-intron	ENST00000265375	ENST00000489388	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-5UTR	ENST00000374706	ENST00000344351	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-5UTR	ENST00000374706	ENST00000354759	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-5UTR	ENST00000374706	ENST00000374721	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-5UTR	ENST00000374706	ENST00000460270	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-5UTR	ENST00000374706	ENST00000474362	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-5UTR	ENST00000374706	ENST00000490511	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000333809	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000337656	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000342105	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000345491	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000348787	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000356917	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000361599	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000374726	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000374728	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000374734	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000395887	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000395895	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000429130	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000439705	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000463314	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000463960	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000468236	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000469949	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000473940	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000474931	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000479070	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000484283	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000487763	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000488328	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000488741	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000489321	CCNY	chr10	35626135	+	CREM	chr10	35495823	+
intron-intron	ENST00000374706	ENST00000489388	CCNY	chr10	35626135	+	CREM	chr10	35495823	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CCNY-CREM

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CCNY	chr10	35626135	+	CREM	chr10	35495822	+	1.39E-10	1
CCNY	chr10	35626135	+	CREM	chr10	35495822	+	1.39E-10	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCNY-CREM

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35626135/:35495823)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CREM Q03060
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269\|PubMed:10373550}.; FUNCTION: [Isoform 6]: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CCNY-CREM

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CCNY-CREM

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CCNY-CREM

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CCNY-CREM

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CCNY	C0009324	Ulcerative Colitis	1	CTD_human
Hgene	CCNY	C0010346	Crohn Disease	1	CTD_human
Hgene	CCNY	C0156147	Crohn's disease of large bowel	1	CTD_human
Hgene	CCNY	C0267380	Crohn's disease of the ileum	1	CTD_human
Hgene	CCNY	C0678202	Regional enteritis	1	CTD_human
Hgene	CCNY	C0949272	IIeocolitis	1	CTD_human
Tgene		C0011875	Diabetic Angiopathies	1	CTD_human
Tgene		C0020564	Hypertrophy	1	CTD_human
Tgene		C0025945	Microangiopathy, Diabetic	1	CTD_human
Tgene		C0027051	Myocardial Infarction	1	CTD_human
Tgene		C0087031	Juvenile-Onset Still Disease	1	CTD_human
Tgene		C0162820	Dermatitis, Allergic Contact	1	CTD_human
Tgene		C0263454	Chloracne	1	CTD_human
Tgene		C3495559	Juvenile arthritis	1	CTD_human
Tgene		C3714758	Juvenile psoriatic arthritis	1	CTD_human
Tgene		C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Tgene		C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:CCNY-CREM (FusionGDB2 ID:HG219771TG1390)

Fusion Gene Summary for CCNY-CREM

Fusion Gene ORF analysis for CCNY-CREM

Fusion Genomic Features for CCNY-CREM

Fusion Protein Features for CCNY-CREM

Fusion Gene Sequence for CCNY-CREM

Fusion Gene PPI Analysis for CCNY-CREM

Related Drugs for CCNY-CREM

Related Diseases for CCNY-CREM

Fusion Gene Studies
in Kim Lab