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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCNY-CUL2 (FusionGDB2 ID:HG219771TG8453)

Fusion Gene Summary for CCNY-CUL2

check button Fusion gene summary
Fusion gene informationFusion gene name: CCNY-CUL2
Fusion gene ID: hg219771tg8453
HgeneTgene
Gene symbol

CCNY

CUL2

Gene ID

219771

8453

Gene namecyclin Ycullin 2
SynonymsC10orf9|CBCP1|CCNX|CFP1-
Cytomap('CCNY')('CUL2')

10p11.21

10p11.21

Type of geneprotein-codingprotein-coding
Descriptioncyclin-Ycyc-Ycyclin box protein 1cyclin fold protein 1cyclin-Xcyclin-box carrying protein 1cullin-2CUL-2testis secretory sperm-binding protein Li 238E
Modification date2020031320200327
UniProtAcc.

Q13617

Ensembl transtripts involved in fusion geneENST00000492478, ENST00000265375, 
ENST00000339497, ENST00000374704, 
ENST00000374706, 
Fusion gene scores* DoF score23 X 14 X 12=38649 X 9 X 8=648
# samples 2716
** MAII scorelog2(27/3864*10)=-3.83906378178494
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/648*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCNY [Title/Abstract] AND CUL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCNY(35790463)-CUL2(35360267), # samples:1
CCNY(35636422)-CUL2(35360267), # samples:1
Anticipated loss of major functional domain due to fusion event.CCNY-CUL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCNY-CUL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCCNY

GO:0000086

G2/M transition of mitotic cell cycle

20059949

HgeneCCNY

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

19524571|20059949

HgeneCCNY

GO:0060828

regulation of canonical Wnt signaling pathway

20059949


check buttonFusion gene breakpoints across CCNY (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CUL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1766CCNYchr10

35790463

+CUL2chr10

35360267

-


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Fusion Gene ORF analysis for CCNY-CUL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000492478ENST00000374746CCNYchr10

35790463

+CUL2chr10

35360267

-
3UTR-5UTRENST00000492478ENST00000374742CCNYchr10

35790463

+CUL2chr10

35360267

-
3UTR-5UTRENST00000492478ENST00000374748CCNYchr10

35790463

+CUL2chr10

35360267

-
3UTR-5UTRENST00000492478ENST00000374749CCNYchr10

35790463

+CUL2chr10

35360267

-
3UTR-5UTRENST00000492478ENST00000374751CCNYchr10

35790463

+CUL2chr10

35360267

-
3UTR-5UTRENST00000492478ENST00000478044CCNYchr10

35790463

+CUL2chr10

35360267

-
3UTR-5UTRENST00000492478ENST00000537177CCNYchr10

35790463

+CUL2chr10

35360267

-
3UTR-5UTRENST00000492478ENST00000602371CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000265375ENST00000374742CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000265375ENST00000374748CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000265375ENST00000374749CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000265375ENST00000374751CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000265375ENST00000478044CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000265375ENST00000537177CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000265375ENST00000602371CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000339497ENST00000374742CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000339497ENST00000374748CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000339497ENST00000374749CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000339497ENST00000374751CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000339497ENST00000478044CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000339497ENST00000537177CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000339497ENST00000602371CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374704ENST00000374742CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374704ENST00000374748CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374704ENST00000374749CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374704ENST00000374751CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374704ENST00000478044CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374704ENST00000537177CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374704ENST00000602371CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374706ENST00000374742CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374706ENST00000374748CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374706ENST00000374749CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374706ENST00000374751CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374706ENST00000478044CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374706ENST00000537177CCNYchr10

35790463

+CUL2chr10

35360267

-
5CDS-5UTRENST00000374706ENST00000602371CCNYchr10

35790463

+CUL2chr10

35360267

-
In-frameENST00000265375ENST00000374746CCNYchr10

35790463

+CUL2chr10

35360267

-
In-frameENST00000339497ENST00000374746CCNYchr10

35790463

+CUL2chr10

35360267

-
In-frameENST00000374704ENST00000374746CCNYchr10

35790463

+CUL2chr10

35360267

-
In-frameENST00000374706ENST00000374746CCNYchr10

35790463

+CUL2chr10

35360267

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374706CCNYchr1035790463+ENST00000374746CUL2chr1035360267-43274244462566706
ENST00000265375CCNYchr1035790463+ENST00000374746CUL2chr1035360267-43474444662586706
ENST00000339497CCNYchr1035790463+ENST00000374746CUL2chr1035360267-42723693912511706
ENST00000374704CCNYchr1035790463+ENST00000374746CUL2chr1035360267-43474444662586706

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374706ENST00000374746CCNYchr1035790463+CUL2chr1035360267-0.0003362450.9996637
ENST00000265375ENST00000374746CCNYchr1035790463+CUL2chr1035360267-0.0002956310.9997043
ENST00000339497ENST00000374746CCNYchr1035790463+CUL2chr1035360267-0.0002782070.9997218
ENST00000374704ENST00000374746CCNYchr1035790463+CUL2chr1035360267-0.0002956310.9997043

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Fusion Genomic Features for CCNY-CUL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CCNY-CUL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:35790463/chr10:35360267)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CUL2

Q13617

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). {ECO:0000269|PubMed:10973499, ECO:0000269|PubMed:11384984, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:9122164}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCNYchr10:35790463chr10:35360267ENST00000265375+310143_26534288.0DomainNote=Cyclin N-terminal
HgeneCCNYchr10:35790463chr10:35360267ENST00000339497+29143_26563317.0DomainNote=Cyclin N-terminal
HgeneCCNYchr10:35790463chr10:35360267ENST00000374704+310143_26588342.0DomainNote=Cyclin N-terminal
HgeneCCNYchr10:35790463chr10:35360267ENST00000374706+512143_26534288.0DomainNote=Cyclin N-terminal


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Fusion Gene Sequence for CCNY-CUL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14211_14211_1_CCNY-CUL2_CCNY_chr10_35790463_ENST00000265375_CUL2_chr10_35360267_ENST00000374746_length(transcript)=4347nt_BP=444nt
AGGCCCCGCCGCCGCCGCCGCTGCTGACCCGGCGGCCGGCCGCCGTTCCGCCCCCTCCCGTGGCGGCGAGCGGGCGGGCCTCCCCACACG
CCCCCGCCGCCCGCGCCCCGCGTCCACCCGCGCCCCGCTCCCGGGGACTGGGAGAACAGGATAGCAGCAGGAGTCGGGGGGCCGCCGAAG
ATGGGGAACACTACCTCGTGCTGCGTGTCGTCCAGTCCCAAGCTCCGGAGGAATGCCCACTCCCGGCTGGAGTCCTACCGGCCAGACACG
GACCTGAGCCGCGAGGACACGGGCTGCAACCTGCAGCACATCAGCGACCGGGAGAACATAGACGATTTGAACATGGAATTCAATCCTTCA
GATCATCCTCGGGCCAGCACAATATTCCTCAGTAAATCTCAGACGGACGTGAGAGAAAAACGCAAGAGTCTCTTCATTAACCATATTTCA
ACACTACACTTGCACAATGTCTTTGAAACCAAGAGTAGTAGATTTTGATGAAACATGGAACAAACTTTTGACGACAATAAAAGCCGTGGT
CATGTTGGAATACGTCGAAAGAGCAACATGGAATGACCGTTTCTCAGATATCTATGCTTTATGTGTGGCCTATCCTGAACCCCTTGGAGA
AAGACTTTATACAGAAACTAAGATTTTTTTGGAAAATCATGTTCGGCATTTGCATAAGAGAGTTTTGGAGTCAGAAGAACAAGTACTTGT
TATGTATCATAGGTACTGGGAAGAATACAGCAAGGGTGCAGACTATATGGACTGCTTATATAGGTATCTCAACACCCAGTTTATTAAAAA
GAATAAATTAACAGAAGCGGACCTTCAGTATGGCTATGGTGGTGTAGATATGAATGAACCACTTATGGAAATAGGAGAGCTAGCATTGGA
TATGTGGAGGAAATTGATGGTTGAACCACTTCAGGCCATCCTTATCCGAATGCTGCTCCGAGAAATCAAAAATGATCGTGGTGGAGAAGA
CCCAAACCAGAAAGTAATCCATGGGGTTATTAACTCCTTTGTTCATGTTGAACAGTATAAGAAAAAATTCCCCTTAAAGTTTTATCAGGA
AATTTTTGAGTCTCCCTTTCTGACTGAAACAGGAGAGTATTACAAACAAGAAGCTTCAAATTTATTACAAGAATCAAACTGCTCACAGTA
TATGGAAAAGGTTCTAGGTAGATTAAAAGATGAAGAAATTCGATGTCGAAAATACCTACATCCAAGTTCATATACTAAGGTGATTCATGA
ATGTCAACAACGAATGGTAGCAGACCACTTACAGTTTTTACATGCAGAATGTCATAATATAATTCGACAAGAGAAAAAAAATGACATGGC
AAATATGTACGTCTTACTCCGTGCTGTGTCCACTGGTTTACCTCATATGATTCAGGAGCTGCAAAACCACATCCATGATGAGGGCCTTCG
AGCAACCAGCAACCTTACTCAGGAAAACATGCCAACACTATTTGTGGAGTCAGTTTTGGAAGTGCATGGTAAATTTGTTCAGCTTATCAA
CACTGTTTTGAATGGTGATCAGCATTTTATGAGTGCGTTGGATAAGGCCCTTACGTCAGTTGTAAATTACAGAGAACCTAAGTCTGTTTG
CAAAGCACCTGAACTGCTTGCTAAGTACTGTGACAACTTACTGAAGAAGTCAGCGAAAGGGATGACAGAGAATGAAGTGGAAGACAGGCT
CACGAGCTTCATCACAGTGTTCAAATACATTGATGACAAGGACGTCTTTCAAAAGTTCTACGCAAGAATGCTGGCAAAACGTTTAATTCA
TGGGTTATCCATGTCTATGGACTCTGAAGAAGCCATGATCAACAAATTAAAGCAAGCCTGTGGTTATGAGTTTACCAGCAAGCTACATCG
GATGTATACAGATATGAGTGTCAGCGCTGATCTCAACAATAAGTTCAACAATTTTATCAAAAACCAAGACACAGTAATAGATTTGGGAAT
TAGTTTTCAAATATATGTTCTACAGGCTGGTGCGTGGCCTCTTACTCAGGCTCCTTCATCTACGTTTGCAATTCCCCAGGAATTAGAAAA
AAGTGTACAGATGTTTGAATTATTTTATAGCCAACATTTCAGTGGAAGGAAACTTACATGGTTACATTATCTGTGTACAGGTGAAGTTAA
AATGAACTATTTGGGCAAACCATATGTAGCCATGGTTACAACATACCAAATGGCAGTTCTTCTTGCCTTTAACAACAGTGAAACTGTCAG
TTATAAAGAGCTTCAGGACAGCACTCAGATGAATGAAAAGGAACTGACAAAAACAATCAAATCATTACTTGATGTGAAAATGATTAACCA
TGATTCAGAAAAGGAAGATATTGATGCAGAATCTTCGTTTTCATTAAATATGAACTTTAGCAGTAAAAGAACAAAATTTAAAATTACTAC
ATCAATGCAGAAAGACACACCACAAGTGATTAGCCAGTCAAGAGCTAGGTTTAATCCCAGTATCAGCATGATTAAGAAGTGTATTGAAGT
TCTGATAGACAAACAATACATAGAACGCAGCCAGGCGTCGGCAGATGAATACAGCTACGTCGCGTGATGTCGCTCTCCTCCAGCGTGGTG
TGAGAAGATCATTGCCATCACCATTTGGTGTGTTCCTGTGGGAAAAAGCAGGACTGTGCCTCCATAATTTGGTCATTTGGCAGCCCCTGT
TTTCTGCTGTTTACAACATCACCAGTGCCACGTCATGAGCGTCAAAGAAAATGCCTAGAGATATTTCAAGCTCATGTCATTATGACATTT
CTTAAAACTTTATTAAAAGAATGAGTGAAGTATTGCTGAAAAGTGGAAATTCGGTTGGGTACCATGCTTTTTCTCCCCTTCACGTTTGCA
GTTGATGTGTCTTTTTTTTTTTTTTTAATGTATCTTAAAGGACATAAAATTTAAAAACTTAAATATTGTAATATGACAGATAACCTAATA
ATTGTATCTACATTAAAATGACAAACATGATACTGCTGCTTGTCAAATAAAAAAAAAATAAAGAAATAGAATGCCTTTTTTATGTGGATG
GAGTATCAGGTTGACCACAAAATATATTGACTCAAAGCAGCTAATGCATCTTTAGTTGCGTTTTTATCTGAATGGTTTAATTCACTTGTA
CTCCTATTTAAATCCTACATGAAAAATGTCTAGATTATTGTTCTTGACTGCATAGGACTGCATTCAGCATAAAGAATGCTTTATTTTTAT
GGATTAGATATATTGGATCTAAACATTTTGAATCTTGAAGATGTAATTCCATCAGCAGTTTCTGGTGGTGTGCTACTCCACAGACATCGC
AGAGTGTGAGCAGGATGCTTGGTGACCTCAAGTCTGGCACAGAGAGAGCTTTTCATTCAAAAGTTGTCTTTCTTCGGTTGCATAATCCAT
TAATTCTAGCATAGACTAGTACCCTAGCTCTGTGGCCTTCCCTGAGTCTTAGGAAATCTATGATACCAACATATTCCTTCTATATGCCTC
CCCTACCTGTTACCCTTACAACCCTCCTCCAACAGTTTAGATACTAGAGTCACTCTCATCAATCACAGATGTGCTTAGCAATGCATAACC
TAAATACTTTTTTAAAAAAGAAAATTGTACATTGTACTGGGTGCCACATATATAAATCCCATTATTTTGTTTATTTTATATATATATATA
TATATAATATATATATATATATATCTCAACAGCAGTGTTAAGAGTACTGCGATCTATTATCATATTTATTGTCTATCCACACCATCACCA
CCACCACCACACCCCTCCTCCCTCAACATACAATTTTTCTTTATTTTAAAAAAAATAAGAGACGGGGTTTCGCCATGTTTCCCAGGCTAG
TCTGGAACTTCTGGCCTCAAGCAATCCTATCTCTGTCTCCCAAAGTGCTGGGATTACAAGCATGAGCCACTGCATCCATCCAACACAAAA
TTTTTAAAATCGGAATATTTTAAAGCAAATCACACAAATTATTTCACTTATAATACTTCAGTAAGGCCTTTAAAAAATCCACAGTGATAT
TATTACTCCTAACAAAAACAATAATTACTTAGTATCATCTAATATGTGGTTCATATTTAAATTTGTTGTTTTGAGATGGGTCTTACAATT
GGTTTATTCAATTGCATTTTTTCTAACTCGTGTCTCAAGTGTTTTAAAAATCTACTGAACTTATAATGACTTATATAATGTATTTCTCAT
TTTACCTTTCTTCCAAAAGAGGAAATAATGGCAAACCATATAATATTGTACATTCACTGTCAAAAAGCAAACCCTTGTTTTGATAACTTG

>14211_14211_1_CCNY-CUL2_CCNY_chr10_35790463_ENST00000265375_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------
>14211_14211_2_CCNY-CUL2_CCNY_chr10_35790463_ENST00000339497_CUL2_chr10_35360267_ENST00000374746_length(transcript)=4272nt_BP=369nt
AGGCCCCGCCGCCGCCGCCGCTGCTGACCCGGCGGCCGGCCGCCGTTCCGCCCCCTCCCGTGGCGGCGAGCGGGCGGGCCTCCCCACACG
CCCCCGCCGCCCGCGCCCCGCGTCCACCCGCGCCCCGCTCCCGGGGACTGGGAGAACAGGATAGCAGCAGGAGTCGGGGGGCCGCCGAAG
ATGGGGAACACTACCTCGTGCTGCGTGTCGTCCAGTCCCAAGCTCCGGAGGAATGCCCACTCCCGGCTGGAGTCCTACCGGCCAGACACG
GACCTGAGCCGCGAGGACACGGGCTGCAACCTGCAGCACATCAGCGACCGGGAGAACATAGACGTGAGAGAAAAACGCAAGAGTCTCTTC
ATTAACCATATTTCAACACTACACTTGCACAATGTCTTTGAAACCAAGAGTAGTAGATTTTGATGAAACATGGAACAAACTTTTGACGAC
AATAAAAGCCGTGGTCATGTTGGAATACGTCGAAAGAGCAACATGGAATGACCGTTTCTCAGATATCTATGCTTTATGTGTGGCCTATCC
TGAACCCCTTGGAGAAAGACTTTATACAGAAACTAAGATTTTTTTGGAAAATCATGTTCGGCATTTGCATAAGAGAGTTTTGGAGTCAGA
AGAACAAGTACTTGTTATGTATCATAGGTACTGGGAAGAATACAGCAAGGGTGCAGACTATATGGACTGCTTATATAGGTATCTCAACAC
CCAGTTTATTAAAAAGAATAAATTAACAGAAGCGGACCTTCAGTATGGCTATGGTGGTGTAGATATGAATGAACCACTTATGGAAATAGG
AGAGCTAGCATTGGATATGTGGAGGAAATTGATGGTTGAACCACTTCAGGCCATCCTTATCCGAATGCTGCTCCGAGAAATCAAAAATGA
TCGTGGTGGAGAAGACCCAAACCAGAAAGTAATCCATGGGGTTATTAACTCCTTTGTTCATGTTGAACAGTATAAGAAAAAATTCCCCTT
AAAGTTTTATCAGGAAATTTTTGAGTCTCCCTTTCTGACTGAAACAGGAGAGTATTACAAACAAGAAGCTTCAAATTTATTACAAGAATC
AAACTGCTCACAGTATATGGAAAAGGTTCTAGGTAGATTAAAAGATGAAGAAATTCGATGTCGAAAATACCTACATCCAAGTTCATATAC
TAAGGTGATTCATGAATGTCAACAACGAATGGTAGCAGACCACTTACAGTTTTTACATGCAGAATGTCATAATATAATTCGACAAGAGAA
AAAAAATGACATGGCAAATATGTACGTCTTACTCCGTGCTGTGTCCACTGGTTTACCTCATATGATTCAGGAGCTGCAAAACCACATCCA
TGATGAGGGCCTTCGAGCAACCAGCAACCTTACTCAGGAAAACATGCCAACACTATTTGTGGAGTCAGTTTTGGAAGTGCATGGTAAATT
TGTTCAGCTTATCAACACTGTTTTGAATGGTGATCAGCATTTTATGAGTGCGTTGGATAAGGCCCTTACGTCAGTTGTAAATTACAGAGA
ACCTAAGTCTGTTTGCAAAGCACCTGAACTGCTTGCTAAGTACTGTGACAACTTACTGAAGAAGTCAGCGAAAGGGATGACAGAGAATGA
AGTGGAAGACAGGCTCACGAGCTTCATCACAGTGTTCAAATACATTGATGACAAGGACGTCTTTCAAAAGTTCTACGCAAGAATGCTGGC
AAAACGTTTAATTCATGGGTTATCCATGTCTATGGACTCTGAAGAAGCCATGATCAACAAATTAAAGCAAGCCTGTGGTTATGAGTTTAC
CAGCAAGCTACATCGGATGTATACAGATATGAGTGTCAGCGCTGATCTCAACAATAAGTTCAACAATTTTATCAAAAACCAAGACACAGT
AATAGATTTGGGAATTAGTTTTCAAATATATGTTCTACAGGCTGGTGCGTGGCCTCTTACTCAGGCTCCTTCATCTACGTTTGCAATTCC
CCAGGAATTAGAAAAAAGTGTACAGATGTTTGAATTATTTTATAGCCAACATTTCAGTGGAAGGAAACTTACATGGTTACATTATCTGTG
TACAGGTGAAGTTAAAATGAACTATTTGGGCAAACCATATGTAGCCATGGTTACAACATACCAAATGGCAGTTCTTCTTGCCTTTAACAA
CAGTGAAACTGTCAGTTATAAAGAGCTTCAGGACAGCACTCAGATGAATGAAAAGGAACTGACAAAAACAATCAAATCATTACTTGATGT
GAAAATGATTAACCATGATTCAGAAAAGGAAGATATTGATGCAGAATCTTCGTTTTCATTAAATATGAACTTTAGCAGTAAAAGAACAAA
ATTTAAAATTACTACATCAATGCAGAAAGACACACCACAAGTGATTAGCCAGTCAAGAGCTAGGTTTAATCCCAGTATCAGCATGATTAA
GAAGTGTATTGAAGTTCTGATAGACAAACAATACATAGAACGCAGCCAGGCGTCGGCAGATGAATACAGCTACGTCGCGTGATGTCGCTC
TCCTCCAGCGTGGTGTGAGAAGATCATTGCCATCACCATTTGGTGTGTTCCTGTGGGAAAAAGCAGGACTGTGCCTCCATAATTTGGTCA
TTTGGCAGCCCCTGTTTTCTGCTGTTTACAACATCACCAGTGCCACGTCATGAGCGTCAAAGAAAATGCCTAGAGATATTTCAAGCTCAT
GTCATTATGACATTTCTTAAAACTTTATTAAAAGAATGAGTGAAGTATTGCTGAAAAGTGGAAATTCGGTTGGGTACCATGCTTTTTCTC
CCCTTCACGTTTGCAGTTGATGTGTCTTTTTTTTTTTTTTTAATGTATCTTAAAGGACATAAAATTTAAAAACTTAAATATTGTAATATG
ACAGATAACCTAATAATTGTATCTACATTAAAATGACAAACATGATACTGCTGCTTGTCAAATAAAAAAAAAATAAAGAAATAGAATGCC
TTTTTTATGTGGATGGAGTATCAGGTTGACCACAAAATATATTGACTCAAAGCAGCTAATGCATCTTTAGTTGCGTTTTTATCTGAATGG
TTTAATTCACTTGTACTCCTATTTAAATCCTACATGAAAAATGTCTAGATTATTGTTCTTGACTGCATAGGACTGCATTCAGCATAAAGA
ATGCTTTATTTTTATGGATTAGATATATTGGATCTAAACATTTTGAATCTTGAAGATGTAATTCCATCAGCAGTTTCTGGTGGTGTGCTA
CTCCACAGACATCGCAGAGTGTGAGCAGGATGCTTGGTGACCTCAAGTCTGGCACAGAGAGAGCTTTTCATTCAAAAGTTGTCTTTCTTC
GGTTGCATAATCCATTAATTCTAGCATAGACTAGTACCCTAGCTCTGTGGCCTTCCCTGAGTCTTAGGAAATCTATGATACCAACATATT
CCTTCTATATGCCTCCCCTACCTGTTACCCTTACAACCCTCCTCCAACAGTTTAGATACTAGAGTCACTCTCATCAATCACAGATGTGCT
TAGCAATGCATAACCTAAATACTTTTTTAAAAAAGAAAATTGTACATTGTACTGGGTGCCACATATATAAATCCCATTATTTTGTTTATT
TTATATATATATATATATATAATATATATATATATATATCTCAACAGCAGTGTTAAGAGTACTGCGATCTATTATCATATTTATTGTCTA
TCCACACCATCACCACCACCACCACACCCCTCCTCCCTCAACATACAATTTTTCTTTATTTTAAAAAAAATAAGAGACGGGGTTTCGCCA
TGTTTCCCAGGCTAGTCTGGAACTTCTGGCCTCAAGCAATCCTATCTCTGTCTCCCAAAGTGCTGGGATTACAAGCATGAGCCACTGCAT
CCATCCAACACAAAATTTTTAAAATCGGAATATTTTAAAGCAAATCACACAAATTATTTCACTTATAATACTTCAGTAAGGCCTTTAAAA
AATCCACAGTGATATTATTACTCCTAACAAAAACAATAATTACTTAGTATCATCTAATATGTGGTTCATATTTAAATTTGTTGTTTTGAG
ATGGGTCTTACAATTGGTTTATTCAATTGCATTTTTTCTAACTCGTGTCTCAAGTGTTTTAAAAATCTACTGAACTTATAATGACTTATA
TAATGTATTTCTCATTTTACCTTTCTTCCAAAAGAGGAAATAATGGCAAACCATATAATATTGTACATTCACTGTCAAAAAGCAAACCCT

>14211_14211_2_CCNY-CUL2_CCNY_chr10_35790463_ENST00000339497_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------
>14211_14211_3_CCNY-CUL2_CCNY_chr10_35790463_ENST00000374704_CUL2_chr10_35360267_ENST00000374746_length(transcript)=4347nt_BP=444nt
AGGCCCCGCCGCCGCCGCCGCTGCTGACCCGGCGGCCGGCCGCCGTTCCGCCCCCTCCCGTGGCGGCGAGCGGGCGGGCCTCCCCACACG
CCCCCGCCGCCCGCGCCCCGCGTCCACCCGCGCCCCGCTCCCGGGGACTGGGAGAACAGGATAGCAGCAGGAGTCGGGGGGCCGCCGAAG
ATGGGGAACACTACCTCGTGCTGCGTGTCGTCCAGTCCCAAGCTCCGGAGGAATGCCCACTCCCGGCTGGAGTCCTACCGGCCAGACACG
GACCTGAGCCGCGAGGACACGGGCTGCAACCTGCAGCACATCAGCGACCGGGAGAACATAGACGATTTGAACATGGAATTCAATCCTTCA
GATCATCCTCGGGCCAGCACAATATTCCTCAGTAAATCTCAGACGGACGTGAGAGAAAAACGCAAGAGTCTCTTCATTAACCATATTTCA
ACACTACACTTGCACAATGTCTTTGAAACCAAGAGTAGTAGATTTTGATGAAACATGGAACAAACTTTTGACGACAATAAAAGCCGTGGT
CATGTTGGAATACGTCGAAAGAGCAACATGGAATGACCGTTTCTCAGATATCTATGCTTTATGTGTGGCCTATCCTGAACCCCTTGGAGA
AAGACTTTATACAGAAACTAAGATTTTTTTGGAAAATCATGTTCGGCATTTGCATAAGAGAGTTTTGGAGTCAGAAGAACAAGTACTTGT
TATGTATCATAGGTACTGGGAAGAATACAGCAAGGGTGCAGACTATATGGACTGCTTATATAGGTATCTCAACACCCAGTTTATTAAAAA
GAATAAATTAACAGAAGCGGACCTTCAGTATGGCTATGGTGGTGTAGATATGAATGAACCACTTATGGAAATAGGAGAGCTAGCATTGGA
TATGTGGAGGAAATTGATGGTTGAACCACTTCAGGCCATCCTTATCCGAATGCTGCTCCGAGAAATCAAAAATGATCGTGGTGGAGAAGA
CCCAAACCAGAAAGTAATCCATGGGGTTATTAACTCCTTTGTTCATGTTGAACAGTATAAGAAAAAATTCCCCTTAAAGTTTTATCAGGA
AATTTTTGAGTCTCCCTTTCTGACTGAAACAGGAGAGTATTACAAACAAGAAGCTTCAAATTTATTACAAGAATCAAACTGCTCACAGTA
TATGGAAAAGGTTCTAGGTAGATTAAAAGATGAAGAAATTCGATGTCGAAAATACCTACATCCAAGTTCATATACTAAGGTGATTCATGA
ATGTCAACAACGAATGGTAGCAGACCACTTACAGTTTTTACATGCAGAATGTCATAATATAATTCGACAAGAGAAAAAAAATGACATGGC
AAATATGTACGTCTTACTCCGTGCTGTGTCCACTGGTTTACCTCATATGATTCAGGAGCTGCAAAACCACATCCATGATGAGGGCCTTCG
AGCAACCAGCAACCTTACTCAGGAAAACATGCCAACACTATTTGTGGAGTCAGTTTTGGAAGTGCATGGTAAATTTGTTCAGCTTATCAA
CACTGTTTTGAATGGTGATCAGCATTTTATGAGTGCGTTGGATAAGGCCCTTACGTCAGTTGTAAATTACAGAGAACCTAAGTCTGTTTG
CAAAGCACCTGAACTGCTTGCTAAGTACTGTGACAACTTACTGAAGAAGTCAGCGAAAGGGATGACAGAGAATGAAGTGGAAGACAGGCT
CACGAGCTTCATCACAGTGTTCAAATACATTGATGACAAGGACGTCTTTCAAAAGTTCTACGCAAGAATGCTGGCAAAACGTTTAATTCA
TGGGTTATCCATGTCTATGGACTCTGAAGAAGCCATGATCAACAAATTAAAGCAAGCCTGTGGTTATGAGTTTACCAGCAAGCTACATCG
GATGTATACAGATATGAGTGTCAGCGCTGATCTCAACAATAAGTTCAACAATTTTATCAAAAACCAAGACACAGTAATAGATTTGGGAAT
TAGTTTTCAAATATATGTTCTACAGGCTGGTGCGTGGCCTCTTACTCAGGCTCCTTCATCTACGTTTGCAATTCCCCAGGAATTAGAAAA
AAGTGTACAGATGTTTGAATTATTTTATAGCCAACATTTCAGTGGAAGGAAACTTACATGGTTACATTATCTGTGTACAGGTGAAGTTAA
AATGAACTATTTGGGCAAACCATATGTAGCCATGGTTACAACATACCAAATGGCAGTTCTTCTTGCCTTTAACAACAGTGAAACTGTCAG
TTATAAAGAGCTTCAGGACAGCACTCAGATGAATGAAAAGGAACTGACAAAAACAATCAAATCATTACTTGATGTGAAAATGATTAACCA
TGATTCAGAAAAGGAAGATATTGATGCAGAATCTTCGTTTTCATTAAATATGAACTTTAGCAGTAAAAGAACAAAATTTAAAATTACTAC
ATCAATGCAGAAAGACACACCACAAGTGATTAGCCAGTCAAGAGCTAGGTTTAATCCCAGTATCAGCATGATTAAGAAGTGTATTGAAGT
TCTGATAGACAAACAATACATAGAACGCAGCCAGGCGTCGGCAGATGAATACAGCTACGTCGCGTGATGTCGCTCTCCTCCAGCGTGGTG
TGAGAAGATCATTGCCATCACCATTTGGTGTGTTCCTGTGGGAAAAAGCAGGACTGTGCCTCCATAATTTGGTCATTTGGCAGCCCCTGT
TTTCTGCTGTTTACAACATCACCAGTGCCACGTCATGAGCGTCAAAGAAAATGCCTAGAGATATTTCAAGCTCATGTCATTATGACATTT
CTTAAAACTTTATTAAAAGAATGAGTGAAGTATTGCTGAAAAGTGGAAATTCGGTTGGGTACCATGCTTTTTCTCCCCTTCACGTTTGCA
GTTGATGTGTCTTTTTTTTTTTTTTTAATGTATCTTAAAGGACATAAAATTTAAAAACTTAAATATTGTAATATGACAGATAACCTAATA
ATTGTATCTACATTAAAATGACAAACATGATACTGCTGCTTGTCAAATAAAAAAAAAATAAAGAAATAGAATGCCTTTTTTATGTGGATG
GAGTATCAGGTTGACCACAAAATATATTGACTCAAAGCAGCTAATGCATCTTTAGTTGCGTTTTTATCTGAATGGTTTAATTCACTTGTA
CTCCTATTTAAATCCTACATGAAAAATGTCTAGATTATTGTTCTTGACTGCATAGGACTGCATTCAGCATAAAGAATGCTTTATTTTTAT
GGATTAGATATATTGGATCTAAACATTTTGAATCTTGAAGATGTAATTCCATCAGCAGTTTCTGGTGGTGTGCTACTCCACAGACATCGC
AGAGTGTGAGCAGGATGCTTGGTGACCTCAAGTCTGGCACAGAGAGAGCTTTTCATTCAAAAGTTGTCTTTCTTCGGTTGCATAATCCAT
TAATTCTAGCATAGACTAGTACCCTAGCTCTGTGGCCTTCCCTGAGTCTTAGGAAATCTATGATACCAACATATTCCTTCTATATGCCTC
CCCTACCTGTTACCCTTACAACCCTCCTCCAACAGTTTAGATACTAGAGTCACTCTCATCAATCACAGATGTGCTTAGCAATGCATAACC
TAAATACTTTTTTAAAAAAGAAAATTGTACATTGTACTGGGTGCCACATATATAAATCCCATTATTTTGTTTATTTTATATATATATATA
TATATAATATATATATATATATATCTCAACAGCAGTGTTAAGAGTACTGCGATCTATTATCATATTTATTGTCTATCCACACCATCACCA
CCACCACCACACCCCTCCTCCCTCAACATACAATTTTTCTTTATTTTAAAAAAAATAAGAGACGGGGTTTCGCCATGTTTCCCAGGCTAG
TCTGGAACTTCTGGCCTCAAGCAATCCTATCTCTGTCTCCCAAAGTGCTGGGATTACAAGCATGAGCCACTGCATCCATCCAACACAAAA
TTTTTAAAATCGGAATATTTTAAAGCAAATCACACAAATTATTTCACTTATAATACTTCAGTAAGGCCTTTAAAAAATCCACAGTGATAT
TATTACTCCTAACAAAAACAATAATTACTTAGTATCATCTAATATGTGGTTCATATTTAAATTTGTTGTTTTGAGATGGGTCTTACAATT
GGTTTATTCAATTGCATTTTTTCTAACTCGTGTCTCAAGTGTTTTAAAAATCTACTGAACTTATAATGACTTATATAATGTATTTCTCAT
TTTACCTTTCTTCCAAAAGAGGAAATAATGGCAAACCATATAATATTGTACATTCACTGTCAAAAAGCAAACCCTTGTTTTGATAACTTG

>14211_14211_3_CCNY-CUL2_CCNY_chr10_35790463_ENST00000374704_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------
>14211_14211_4_CCNY-CUL2_CCNY_chr10_35790463_ENST00000374706_CUL2_chr10_35360267_ENST00000374746_length(transcript)=4327nt_BP=424nt
AGGAGAGATGTGAGCCTCGTACCAGGAAGATCATACTGAGGCCACCAGGTTGAGAGCCGCCTGGCTGGGGGGCTTGTCCGGGGACAGCAG
GGGCAGAGGCATGGAGGTTCACAGCCAGGAAATCGTGCAGTGAACCTGTCCCCTCCGGTCACAACATCAAGAGCTGAACTGGGACTAGAA
GTCATCGCCCCAGAGCTTTTTGCTACCAGAACTGCCGGGTGAAAATCTTTGGAAGAGAAGTTTGAGAACCTGTTAAACAAGCTCTCTAGG
TAATTCTGTGCACGTTCAGTCTGAGAACTGCTGCATCTGAAGAGATTTGAACATGGAATTCAATCCTTCAGATCATCCTCGGGCCAGCAC
AATATTCCTCAGTAAATCTCAGACGGACGTGAGAGAAAAACGCAAGAGTCTCTTCATTAACCATATTTCAACACTACACTTGCACAATGT
CTTTGAAACCAAGAGTAGTAGATTTTGATGAAACATGGAACAAACTTTTGACGACAATAAAAGCCGTGGTCATGTTGGAATACGTCGAAA
GAGCAACATGGAATGACCGTTTCTCAGATATCTATGCTTTATGTGTGGCCTATCCTGAACCCCTTGGAGAAAGACTTTATACAGAAACTA
AGATTTTTTTGGAAAATCATGTTCGGCATTTGCATAAGAGAGTTTTGGAGTCAGAAGAACAAGTACTTGTTATGTATCATAGGTACTGGG
AAGAATACAGCAAGGGTGCAGACTATATGGACTGCTTATATAGGTATCTCAACACCCAGTTTATTAAAAAGAATAAATTAACAGAAGCGG
ACCTTCAGTATGGCTATGGTGGTGTAGATATGAATGAACCACTTATGGAAATAGGAGAGCTAGCATTGGATATGTGGAGGAAATTGATGG
TTGAACCACTTCAGGCCATCCTTATCCGAATGCTGCTCCGAGAAATCAAAAATGATCGTGGTGGAGAAGACCCAAACCAGAAAGTAATCC
ATGGGGTTATTAACTCCTTTGTTCATGTTGAACAGTATAAGAAAAAATTCCCCTTAAAGTTTTATCAGGAAATTTTTGAGTCTCCCTTTC
TGACTGAAACAGGAGAGTATTACAAACAAGAAGCTTCAAATTTATTACAAGAATCAAACTGCTCACAGTATATGGAAAAGGTTCTAGGTA
GATTAAAAGATGAAGAAATTCGATGTCGAAAATACCTACATCCAAGTTCATATACTAAGGTGATTCATGAATGTCAACAACGAATGGTAG
CAGACCACTTACAGTTTTTACATGCAGAATGTCATAATATAATTCGACAAGAGAAAAAAAATGACATGGCAAATATGTACGTCTTACTCC
GTGCTGTGTCCACTGGTTTACCTCATATGATTCAGGAGCTGCAAAACCACATCCATGATGAGGGCCTTCGAGCAACCAGCAACCTTACTC
AGGAAAACATGCCAACACTATTTGTGGAGTCAGTTTTGGAAGTGCATGGTAAATTTGTTCAGCTTATCAACACTGTTTTGAATGGTGATC
AGCATTTTATGAGTGCGTTGGATAAGGCCCTTACGTCAGTTGTAAATTACAGAGAACCTAAGTCTGTTTGCAAAGCACCTGAACTGCTTG
CTAAGTACTGTGACAACTTACTGAAGAAGTCAGCGAAAGGGATGACAGAGAATGAAGTGGAAGACAGGCTCACGAGCTTCATCACAGTGT
TCAAATACATTGATGACAAGGACGTCTTTCAAAAGTTCTACGCAAGAATGCTGGCAAAACGTTTAATTCATGGGTTATCCATGTCTATGG
ACTCTGAAGAAGCCATGATCAACAAATTAAAGCAAGCCTGTGGTTATGAGTTTACCAGCAAGCTACATCGGATGTATACAGATATGAGTG
TCAGCGCTGATCTCAACAATAAGTTCAACAATTTTATCAAAAACCAAGACACAGTAATAGATTTGGGAATTAGTTTTCAAATATATGTTC
TACAGGCTGGTGCGTGGCCTCTTACTCAGGCTCCTTCATCTACGTTTGCAATTCCCCAGGAATTAGAAAAAAGTGTACAGATGTTTGAAT
TATTTTATAGCCAACATTTCAGTGGAAGGAAACTTACATGGTTACATTATCTGTGTACAGGTGAAGTTAAAATGAACTATTTGGGCAAAC
CATATGTAGCCATGGTTACAACATACCAAATGGCAGTTCTTCTTGCCTTTAACAACAGTGAAACTGTCAGTTATAAAGAGCTTCAGGACA
GCACTCAGATGAATGAAAAGGAACTGACAAAAACAATCAAATCATTACTTGATGTGAAAATGATTAACCATGATTCAGAAAAGGAAGATA
TTGATGCAGAATCTTCGTTTTCATTAAATATGAACTTTAGCAGTAAAAGAACAAAATTTAAAATTACTACATCAATGCAGAAAGACACAC
CACAAGTGATTAGCCAGTCAAGAGCTAGGTTTAATCCCAGTATCAGCATGATTAAGAAGTGTATTGAAGTTCTGATAGACAAACAATACA
TAGAACGCAGCCAGGCGTCGGCAGATGAATACAGCTACGTCGCGTGATGTCGCTCTCCTCCAGCGTGGTGTGAGAAGATCATTGCCATCA
CCATTTGGTGTGTTCCTGTGGGAAAAAGCAGGACTGTGCCTCCATAATTTGGTCATTTGGCAGCCCCTGTTTTCTGCTGTTTACAACATC
ACCAGTGCCACGTCATGAGCGTCAAAGAAAATGCCTAGAGATATTTCAAGCTCATGTCATTATGACATTTCTTAAAACTTTATTAAAAGA
ATGAGTGAAGTATTGCTGAAAAGTGGAAATTCGGTTGGGTACCATGCTTTTTCTCCCCTTCACGTTTGCAGTTGATGTGTCTTTTTTTTT
TTTTTTAATGTATCTTAAAGGACATAAAATTTAAAAACTTAAATATTGTAATATGACAGATAACCTAATAATTGTATCTACATTAAAATG
ACAAACATGATACTGCTGCTTGTCAAATAAAAAAAAAATAAAGAAATAGAATGCCTTTTTTATGTGGATGGAGTATCAGGTTGACCACAA
AATATATTGACTCAAAGCAGCTAATGCATCTTTAGTTGCGTTTTTATCTGAATGGTTTAATTCACTTGTACTCCTATTTAAATCCTACAT
GAAAAATGTCTAGATTATTGTTCTTGACTGCATAGGACTGCATTCAGCATAAAGAATGCTTTATTTTTATGGATTAGATATATTGGATCT
AAACATTTTGAATCTTGAAGATGTAATTCCATCAGCAGTTTCTGGTGGTGTGCTACTCCACAGACATCGCAGAGTGTGAGCAGGATGCTT
GGTGACCTCAAGTCTGGCACAGAGAGAGCTTTTCATTCAAAAGTTGTCTTTCTTCGGTTGCATAATCCATTAATTCTAGCATAGACTAGT
ACCCTAGCTCTGTGGCCTTCCCTGAGTCTTAGGAAATCTATGATACCAACATATTCCTTCTATATGCCTCCCCTACCTGTTACCCTTACA
ACCCTCCTCCAACAGTTTAGATACTAGAGTCACTCTCATCAATCACAGATGTGCTTAGCAATGCATAACCTAAATACTTTTTTAAAAAAG
AAAATTGTACATTGTACTGGGTGCCACATATATAAATCCCATTATTTTGTTTATTTTATATATATATATATATATAATATATATATATAT
ATATCTCAACAGCAGTGTTAAGAGTACTGCGATCTATTATCATATTTATTGTCTATCCACACCATCACCACCACCACCACACCCCTCCTC
CCTCAACATACAATTTTTCTTTATTTTAAAAAAAATAAGAGACGGGGTTTCGCCATGTTTCCCAGGCTAGTCTGGAACTTCTGGCCTCAA
GCAATCCTATCTCTGTCTCCCAAAGTGCTGGGATTACAAGCATGAGCCACTGCATCCATCCAACACAAAATTTTTAAAATCGGAATATTT
TAAAGCAAATCACACAAATTATTTCACTTATAATACTTCAGTAAGGCCTTTAAAAAATCCACAGTGATATTATTACTCCTAACAAAAACA
ATAATTACTTAGTATCATCTAATATGTGGTTCATATTTAAATTTGTTGTTTTGAGATGGGTCTTACAATTGGTTTATTCAATTGCATTTT
TTCTAACTCGTGTCTCAAGTGTTTTAAAAATCTACTGAACTTATAATGACTTATATAATGTATTTCTCATTTTACCTTTCTTCCAAAAGA
GGAAATAATGGCAAACCATATAATATTGTACATTCACTGTCAAAAAGCAAACCCTTGTTTTGATAACTTGTTGATTGATAAAAGTTTTCC

>14211_14211_4_CCNY-CUL2_CCNY_chr10_35790463_ENST00000374706_CUL2_chr10_35360267_ENST00000374746_length(amino acids)=706AA_BP=
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCNY-CUL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCNY-CUL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCNY-CUL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCNYC0009324Ulcerative Colitis1CTD_human
HgeneCCNYC0010346Crohn Disease1CTD_human
HgeneCCNYC0156147Crohn's disease of large bowel1CTD_human
HgeneCCNYC0267380Crohn's disease of the ileum1CTD_human
HgeneCCNYC0678202Regional enteritis1CTD_human
HgeneCCNYC0949272IIeocolitis1CTD_human
TgeneC0021390Inflammatory Bowel Diseases1CTD_human