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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:MICU2-ATP8A2 (FusionGDB2 ID:HG221154TG51761)

Fusion Gene Summary for MICU2-ATP8A2

check button Fusion gene summary
Fusion gene informationFusion gene name: MICU2-ATP8A2
Fusion gene ID: hg221154tg51761
HgeneTgene
Gene symbol

MICU2

ATP8A2

Gene ID

221154

51761

Gene namemitochondrial calcium uptake 2ATPase phospholipid transporting 8A2
Synonyms1110008L20Rik|EFHA1ATP|ATPIB|CAMRQ4|IB|ML-1
Cytomap('EFHA1','MICU2')('ATP8A2','ATP8A2')

13q12.11

13q12.13

Type of geneprotein-codingprotein-coding
Descriptioncalcium uptake protein 2, mitochondrialEF hand domain family A1EF hand domain family, member A1EF-hand domain-containing family member A1Smhs2 homologphospholipid-transporting ATPase IBATPase, aminophospholipid transporter, class I, type 8A, member 2ATPase, aminophospholipid transporter-like, class I, type 8A, member 2P4-ATPase flippase complex alpha subunit ATP8A2probable phospholipid-transporting
Modification date2020031520200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000382374, ENST00000479790, 
Fusion gene scores* DoF score5 X 3 X 3=4513 X 13 X 7=1183
# samples 515
** MAII scorelog2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/1183*10)=-2.97941566784391
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MICU2 [Title/Abstract] AND ATP8A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEFHA1(22178077)-ATP8A2(26402255), # samples:1
EFHA1(22178078)-ATP8A2(26402256), # samples:1
MICU2(22178078)-ATP8A2(26402256), # samples:2
Anticipated loss of major functional domain due to fusion event.MICU2-ATP8A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MICU2-ATP8A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MICU2-ATP8A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MICU2-ATP8A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMICU2

GO:0006851

mitochondrial calcium ion transmembrane transport

24560927

HgeneMICU2

GO:0051562

negative regulation of mitochondrial calcium ion concentration

24560927


check buttonFusion gene breakpoints across MICU2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ATP8A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A22D-01AEFHA1chr13

22178078

-ATP8A2chr13

26402256

+
ChimerDB4BRCATCGA-E9-A22DEFHA1chr13

22178077

-ATP8A2chr13

26402255

+
ChimerDB4BRCATCGA-E9-A22D-01AMICU2chr13

22178078

-ATP8A2chr13

26402256

+


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Fusion Gene ORF analysis for MICU2-ATP8A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000382374ENST00000491840MICU2chr13

22178078

-ATP8A2chr13

26402256

+
5CDS-intronENST00000382374ENST00000255283MICU2chr13

22178078

-ATP8A2chr13

26402256

+
In-frameENST00000382374ENST00000381655MICU2chr13

22178078

-ATP8A2chr13

26402256

+
intron-3CDSENST00000479790ENST00000381655MICU2chr13

22178078

-ATP8A2chr13

26402256

+
intron-3UTRENST00000479790ENST00000491840MICU2chr13

22178078

-ATP8A2chr13

26402256

+
intron-intronENST00000479790ENST00000255283MICU2chr13

22178078

-ATP8A2chr13

26402256

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000382374MICU2chr1322178078-ENST00000381655ATP8A2chr1326402256+7030276661163365

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382374ENST00000381655MICU2chr1322178078-ATP8A2chr1326402256+0.0143144620.9856856

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Fusion Genomic Features for MICU2-ATP8A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MICU2-ATP8A2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:22178077/chr13:26402255)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMICU2chr13:22178078chr13:26402256ENST00000382374-1122_5070435.0Compositional biasNote=Ala-rich
TgeneATP8A2chr13:22178078chr13:26402256ENST0000038165526371019_10288931189.0Topological domainCytoplasmic
TgeneATP8A2chr13:22178078chr13:26402256ENST0000038165526371050_10638931189.0Topological domainExtracellular
TgeneATP8A2chr13:22178078chr13:26402256ENST0000038165526371085_11888931189.0Topological domainCytoplasmic
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637909_9108931189.0Topological domainExtracellular
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637932_9598931189.0Topological domainCytoplasmic
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637981_9978931189.0Topological domainExtracellular
TgeneATP8A2chr13:22178078chr13:26402256ENST0000038165526371029_10498931189.0TransmembraneHelical
TgeneATP8A2chr13:22178078chr13:26402256ENST0000038165526371064_10848931189.0TransmembraneHelical
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637911_9318931189.0TransmembraneHelical
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637960_9808931189.0TransmembraneHelical
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637998_10188931189.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMICU2chr13:22178078chr13:26402256ENST00000382374-112172_20770435.0DomainEF-hand 1
HgeneMICU2chr13:22178078chr13:26402256ENST00000382374-112227_26270435.0DomainEF-hand 2
HgeneMICU2chr13:22178078chr13:26402256ENST00000382374-112293_32870435.0DomainEF-hand 3
HgeneMICU2chr13:22178078chr13:26402256ENST00000382374-112362_39770435.0DomainEF-hand 4
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637116_1198931189.0Topological domainExtracellular
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637141_3168931189.0Topological domainCytoplasmic
TgeneATP8A2chr13:22178078chr13:26402256ENST0000038165526371_948931189.0Topological domainCytoplasmic
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637338_3648931189.0Topological domainExtracellular
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637386_8878931189.0Topological domainCytoplasmic
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637120_1408931189.0TransmembraneHelical
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637317_3378931189.0TransmembraneHelical
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637365_3858931189.0TransmembraneHelical
TgeneATP8A2chr13:22178078chr13:26402256ENST000003816552637888_9088931189.0TransmembraneHelical
TgeneATP8A2chr13:22178078chr13:26402256ENST00000381655263795_1158931189.0TransmembraneHelical


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Fusion Gene Sequence for MICU2-ATP8A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>53580_53580_1_MICU2-ATP8A2_MICU2_chr13_22178078_ENST00000382374_ATP8A2_chr13_26402256_ENST00000381655_length(transcript)=7030nt_BP=276nt
GAGAGTTCCCAAGCGGTAGGCGGCGGCGCCGGGAGAGAAGCGCCGCCTAGCTGCGCTTCCGCAAAGATGGCGGCGGCTGCGGGTAGCTGC
GCGCGGGTGGCGGCCTGGGGCGGAAAACTGCGACGGGGGCTCGCTGTCAGCCGACAGGCTGTGCGGAGTCCCGGCCCCTTGGCAGCGGCA
GTGGCCGGCGCGGCCCTGGCAGGAGCAGGAGCGGCCTGGCACCACAGCCGCGTCAGTGTTGCGGCGCGGGATGGCAGTTTTACAGTCTCC
GCACAGCTTTGGTTCGCCTTTGTTAATGGATTTTCTGGGCAGATTTTATTTGAACGTTGGTGCATCGGCCTGTACAATGTGATTTTCACC
GCTTTGCCGCCCTTCACTCTGGGAATCTTTGAGAGGTCTTGCACTCAGGAGAGCATGCTCAGGTTTCCCCAGCTCTACAAAATCACCCAG
AATGGCGAAGGCTTCAACACAAAGGTTTTCTGGGGTCACTGCATCAACGCCTTGGTCCACTCCCTCATCCTCTTCTGGTTTCCCATGAAA
GCTCTGGAGCATGATACTGTGTTGACAAGTGGTCATGCTACCGACTATTTATTTGTTGGAAATATTGTTTACACATATGTTGTTGTTACT
GTTTGTCTGAAAGCTGGTTTGGAGACCACAGCTTGGACTAAATTCAGTCATCTGGCTGTCTGGGGAAGCATGCTGACCTGGCTGGTGTTT
TTTGGCATCTACTCGACCATCTGGCCCACCATTCCCATTGCTCCAGATATGAGAGGACAGGCAACTATGGTCCTGAGCTCCGCACACTTC
TGGTTGGGATTATTTCTGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTG
GAGGAGGTGCAGGAGCTGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGAC
CGCCTGATCAAGAGGCTGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTT
TCTCAAGAAGAACACGGAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATG
AATTTTCCTGACTGATCTTAGGAAAGAGATTCAGTTTGTTGCACCCAGTGTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCA
AAACACCAGGAAACACATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGA
AGCTATCTTTGCCCTCCCAACTCGTCTGCAGTGCTTAGCCTAACTTTTGTTTATGTCGTTATGAAGCATTCAACTGTGCTCTGTGAGGTG
TGAAATTAAAAACATTATGTTTCACCAATATTTAAACATCAGTACTAGTTGTCCTGGGAGAAAGGGAAAGGAGTTTTATGTTGCGTGAGA
GGCCCATCCTGTGTAATTGGAGCAGGGCACACTTGCTTCCTGTTGAGTTAACTCAGAGGTTAAGTCCAACGGGCCACATGCAGACTTCAC
TGTAGGCAGGTTGCTCTCCTGCTTTGATTCCTGTTTTGTGTGTAAAATTGGCATAAACTTCTTGATTGCAGTGAAATCACAAAATTCTCT
ATCGGGGTGGTCAACCTGAGAACATTTATTTGAACCTCTTAGCCACATTTCCAGCAGGGCAAACCAACTGATGCCCTGGAAGAGTCTTCC
GCACCCTCTCCAGGTGCACTCGGCCCAGTCCTGCCGCCGTGTCCAGGCGCCCCTCACCCCCACACCTGCTGCATGGCTGGCCACACCACT
CAGTGCATGGCGGCCGATGGGCAGCCAACCCAAACCCGCGCCTTTCCTTGTTCCACTGCAGACTCAGATACAGATGCGAAAAATTCCTTC
TTCCACCGCCCTTCTCGTTCTGTAAAGAAAGAAAAGAAACATAGCCTTTCTGCATATATTCTAAACGTCTCTCTGCCTCTGTCTGACATG
GGGCCACCCCACAGGTCAGAGTGGTGGTAGAACCCCTTCAGGACTCCCAGCCGTGGTCAGGCTCTGAATACTCCCTTCCCAACATCCAGA
CTGCTGGGCCTTTGGCATCCACTTACATTAGAACCCACGTTTGTTTCAGAGCACATTTTGGACTTTCACTGTTGGGAAATGAATGAATTT
ATAACATGCCTGCACAGCGAAGGAACACACCTGTCGCTCTTAGCTCTAGAGTCAGAGGATGAGTAAACCCAGATGCAAGAGTATAGGACA
TTGAGTGGGGAGAACAAGACGACCACAGAAGTCCTCAGAAGGAGAAGGAAGGACACGGAGACACTGAGAGGAGGACACAGAGGAATCGCC
ACCAGATCTTTGCAGTAGAAACTCTGAAATAGGCCTTGAGACCCAGACAATTGTCATGATCAGCCCAGTGTGTATGAGAGCTTAAACAAG
ACCTTCACACACAGTTCTAATTGAAAAGAATTCCAAACATTTCAGGGAAACACCTTTTTAAAAAATATACTGACATGGTTTCCTTTCTGT
ATCCCATCAGTGTTAGACACAGGTACCTATCAGAATACGGCATATCCTGAATTATCTAAGACAAGGAAGTGAAGAGCGGAATCACTGACT
TTCCCAACTGCAGAGTCCCACACTTAAATCTCAACAGAACCTAGATGTCTTCAGGCATGAATGTGAGCACCTGGAGCCCTTACTAAACAA
CCTGCCTGGAGCCCTGTTCTCTGCTCTGGTTGCCAAACCAGATTTTTGGATGGCCTAAATACTTGTGGGCAACTGTTACTGGTGAAAAAT
GGGAGTGGAGAGCATGTTTTGGATTTTCACTGTGGGGAAATGAATGAATTTATCACATGACTGTGCAGCGAAGGAGCACACCTGTCACTC
TTAGCTCTAGAGTCGGAGGATGAGTCAACCCTGTAGGAATGATTGTGCTAAATTAGGAAATAACACTTTAGTGCACTTTGCTTCCTAACC
CTTTTTTGTCAGAAATCTACAACCTACTGGGCATGGAAATGATTTAAAATATGATCTGCATTGACTAAGAAAACTCATCCTCACTTATGA
GGTGACCAGGATGCAGAGAGGGCCTGAGGGGCAGCAGAACAATGCAATTCACAGGTGAGGCTCCAAAAAGGGCCATTTCTTTCTCCCCAA
GGTGCATAGAACATTTTTAAATATCAGAGTACCCAGCAAGACGGAAGGACTGTCATGCAGGAACTCTAACACAAAATGTGCCTATGACTA
ACACGACAAACCAAGGTGTATGGTTTCTTTGCACACCCAGAAAGGTGATGGCCAAGATACAGAGGAGAAACGAAAACTGGAATTGAATGT
GCATTAGGCATCTTAACTATTCATATTTTGTCTCATTTGGGAACTAAGCCTATTTGGAAAGAGTGGATTAGAAATTGAATTCTTTGTCAA
ACAGTTAGCTCTGTCTTGAACTTGAAGCCTTCCAAATCAGAATTATGTATTTAAGTGTGTGTTTGTGTTTGTTTGGGGTTTTTGTTTCTT
ACATTAGAGTTCATATTTTCTGGGATTTAAGGATACAGGTGTATTTTCCTATTCTCTTGAGAAGTAGACTAAACAATATTTGCAGTGATG
ACAGACGCACACAGAAGAAAACATTAGAAGAGATGCCTTTCTATCCTCTCATGTGGTTGAGCATTCTTACAGCCAAATGACTAAATTGGC
TGTAAATTGGTTTCTAGGAGGAGCAGCTGTCACTACGTGTGATGTATAATATTTAGCCAGGGCCAACTCAGGGGCTGTGTCATTTGTCCT
ATCTTTAAATTGAGGTCAGAGTGTCACACACAACCCCTCCCCTGGGGCAGGGTGGACTGGACTAGGTTGCATACGCTGGCTGTCAGCTCA
GCAAAAATGCCACATGGGGCTTGTCACTCCGCCAGACACTCACTGACTCACGGGCTGGCAGGTCACGCTCGGTTAGCGCTCCAGGGCCTG
ACTCTGGATTGAGCTAAACTGGCAGAATCCACTCAGGCCAACCCTTGGTCTACTGCTGTGTACAGACAGCCCAGTCCTGTGTTGAGTCTC
TCTTCTCCTGGATGACCCTGCAAAAGGAAGAGACCAGTTGTACTGTGGGCTTAGTTCTGGGTTTCCACTGCACACTGACACGTGCCAGCA
AGGGTAGCTGTGGAAAACACGTATCAGGAGAGCAGAGTAGTCTGGATGAATACTCTGTGCTGATCAGAACGGGCTCGGTCATAATTTAGG
AGTGGAGCTGATGTGTCTGTCCTGCCTCAGTGCAGAATATTCCAGGCTTCTTGACCAGGGTTATGTTCACCCATCTCCCAACACACACAT
GCACACATGAAAACAAAAACATGGTAACTCTTTTGGTTCGGCACACCATACAAAACGTGCTTTGGGGCGAGGAGTGCTGTTTCTTTTAAC
ACTTGTAGAGGAATATCCTGAGAAGTGAACCTGGGCTTTGGGAGAGCTCAGCTGAGAATTCTGTTGACATTTTCTTTCCCTTGACAAGGC
TTCAGGTTCGTCTCACTATAGGGAGCTGGCTGTGAAAATCAGTAATAACTTGTCAAGAAGCAGTGAAAAATGCGGGGGGGTGGAAAGAGC
CTAGGTAACTAATGTCTTATAATGCATATGTATGTAAATATTACAGGATTTAAGGTTGAATTTTTTAAAAAGAAAGTTATAGTCTGTAAT
TTCCATTTGTTATAATAATGACCTTTAATCTTGTCATTTGGAACCATAAAGCATTTTTATCAGGTACCTCTGTTCCAAGGGATTTATGTC
TTAGACCATAGCTGAATTGAATGTTTGCAAAACACTGCTATAGGATAAGGTGGTCTTTAGTTTTGAACGTGTGAAAGGACTGCACACTTT
TCAGCCAGGGTTTGAGTTACTGCCCAGGGTCATCGTCTCAAAGTAATTCAAGGAGTGATTTAACATCAGCATTTGAAATGTAGTCTTCAT
CTCCTGGGATCCATAAAAAAATGTGAACAGGGAAATGGTGGCTAAGCAGAGCCTGAAATAATAACTTGGCAAAGAAATGAGTTTATCAGG
TCGAGTCAAAACATGGCATCCCCTGTTACACTCAAGAAATGTTTTCTTCATGTAAATGTTTATACGGGCATATATAATCACAATGGGAAC
AGTTAAAACCCCCTCCCTTCAAAAAAAGAAAATCTATATCAGTTGGGTTTGGTTTTGGTTCTTCATTGGCTCAAGGCAGTTAACTGTCTC
AGTATAGCCTTCGGGGAGATTTAACCTCATTCTAGCCATTTTTCCATCCTGAAGGCCAAGAAGGACTATTAGAAGGGTTTTTGAGGGGTT
TCGGAGGTGAGGGCCCAAGACCCCCATAATGACATCATTAGGCATTCTTGAAAGGTGTTAACAGACCAGCACGCTCGATGTGTTGTACCC
TTCATTTATTTTTTTTTCTCAGCATCCCAAGTTGTCCATCAGTACATTCCCCTTCACCTTACCTGATCTTCATTTAATGCCCAGTCTGTA
ACTAATGTTCTGTTTAAAGCTCTCTTAATTTGTTGGCTATGAGTGATTTGTGAATCTGGGATGTAACCCTGAGTGAGGAGAAAAGGGCAT
TGAGCCAGCATAAATCTGAATGGGCAGAAGCCACAAACAAATGGGAGCAGAAAAGAAGGGCGAGCTCCCCCGCGCCGCACCCCGTGTATA
ATCCAGTGTTAACCTCTGAGGAACACCTCGGCTCTCCCAACTGAGGAGAGACAAAAGAGGGATTCTTTTTACACCCAGGCTGGCGCATTT
TCAAGTGACAATCTCGGGCTCTAGTTGCCTTTGAGATATCCACTCTGCTCTTTCTCCCAGGCCTCAGACCAAGAAAAACATGCTCTCAAG
ATTAGCCCATAGGCAGTTCTTGTGACCTGGCTGAAGAAAGAAAGGAGACCTGTTTGTTTTAAAAGTCGGGCGCAAAGTGTCAGGTGGCTT
TGATTTATGACAGAAAGAGGAAGAAGAAAGTTGGAGTAATAGCACTATCCAAATAACCCTGCCCAGGAAACTTGGGGGTCAAGAGAGCTT
ATCAAGAGCCTTTTATAGGTAAGCTCTTCCGTGTGAAAGAGAAAAGGCCGGAAAGAGGGAGAGAGCCCAGAGAGCAGGCTGCGAACTCAC
TTCCAATGGGATTGGAGTCTGTTGTATTCTTAAGAGATAGCCTGATATGTGGTTTATAGGTGAATCAATAAACACCAACAACAACAAAAA
AAAAAAAAAAAAAAAAGGAAGAAAAGAAAAAAAGGAAACCAGCCCTGTCATGGAATTTCTCTCCTTCCCTGCACAGTAAAGACTTTTGGG
TTTTCATGGATAAAATCAATGTCAGTACTGAAACTCCTACTCTCCCCTCCCGCCCCACTCTCCCCCGTTGCCCGAGATGGCCAAGTTCAG
GCCTGTGCAATGCCGCTTCCCTCTGAGCCTCCCTCTCAAGGGCCACGCAGGCAGCTGCAGCAGGGCCAGCTGCAGGATGGGGCTGCCGGT
CACTGAATTGTCGTTCAAATGCATCATCTTTGTGGCGTCTTTCTCATGCGAGCAAAGCCACGTGCTCTCCTGTCTGCTGTCACATCTGTG
CCTGGATTGCTTAAATATTGTTTGTGATGGGGAGGTTTTAATCTGGTGATGCAGAGGGAAGCAGGGCTGTGGGGGCACGTTTAATTGGCT
CCCAGCAGCGTGGGGGGTGCTTCTATGGTGTGTGGGGTTTTTTGTTGCCTCCCTCTAGAAGTGTTACCGTTTTCACGTCCTATTAATGTC
CTCTGGTTGTTAAATTACAGCAGCACATTACAGTGCACTGGGTTCCCTCCTGGAGTGAATACAAACGGAGGGCATCTACTTGTATTTTTA
GAAGTTTTGGGAGAATTTAGTGATTTGTGGCTTTGATCAATCCTGTTGACTGGTGTATGTCTGCGCAAACCTGTTTCAAATAAATCTTTT
GTTAAAGTAA

>53580_53580_1_MICU2-ATP8A2_MICU2_chr13_22178078_ENST00000382374_ATP8A2_chr13_26402256_ENST00000381655_length(amino acids)=365AA_BP=69
MAAAAGSCARVAAWGGKLRRGLAVSRQAVRSPGPLAAAVAGAALAGAGAAWHHSRVSVAARDGSFTVSAQLWFAFVNGFSGQILFERWCI
GLYNVIFTALPPFTLGIFERSCTQESMLRFPQLYKITQNGEGFNTKVFWGHCINALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNI
VYTYVVVTVCLKAGLETTAWTKFSHLAVWGSMLTWLVFFGIYSTIWPTIPIAPDMRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAK
HTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQGVPHGYAFSQEEHGAVSQEEVIRAYDTTKK
KSRKK

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Fusion Gene PPI Analysis for MICU2-ATP8A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MICU2-ATP8A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MICU2-ATP8A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3808977CEREBELLAR ATAXIA, MENTAL RETARDATION, AND DYSEQUILIBRIUM SYNDROME 42GENOMICS_ENGLAND;UNIPROT
TgeneC0394006Dysequilibrium syndrome1ORPHANET
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND