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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:C6orf136-AKR1C1 (FusionGDB2 ID:HG221545TG1645) |
Fusion Gene Summary for C6orf136-AKR1C1 |
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Fusion gene information | Fusion gene name: C6orf136-AKR1C1 | Fusion gene ID: hg221545tg1645 | Hgene | Tgene | Gene symbol | C6orf136 | AKR1C1 | Gene ID | 221545 | 1645 |
Gene name | chromosome 6 open reading frame 136 | aldo-keto reductase family 1 member C1 | |
Synonyms | - | 2-ALPHA-HSD|20-ALPHA-HSD|C9|DD1|DD1/DD2|DDH|DDH1|H-37|HAKRC|HBAB|MBAB | |
Cytomap | ('C6orf136')('AKR1C1') 6p21.33 | 10p15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | uncharacterized protein C6orf136 | aldo-keto reductase family 1 member C120 alpha-hydroxysteroid dehydrogenasealdo-keto reductase Cchlordecone reductase homolog HAKRCdihydrodiol dehydrogenase 1dihydrodiol dehydrogenase 1/2dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q5SQH8 | . | |
Ensembl transtripts involved in fusion gene | ENST00000293604, ENST00000376473, ENST00000528347, ENST00000376471, ENST00000383580, ENST00000383581, ENST00000415931, ENST00000417076, ENST00000417649, ENST00000419321, ENST00000422530, ENST00000425581, ENST00000430141, ENST00000447505, ENST00000455682, ENST00000456444, ENST00000459700, ENST00000466518, ENST00000472341, ENST00000486177, ENST00000491140, ENST00000493705, ENST00000496234, ENST00000546452, ENST00000547308, ENST00000549361, ENST00000549800, ENST00000549861, ENST00000552569, | ||
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 3 X 4=60 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: C6orf136 [Title/Abstract] AND AKR1C1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | C6orf136(30617736)-AKR1C1(5008106), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | AKR1C1 | GO:0007586 | digestion | 8486699 |
Tgene | AKR1C1 | GO:0008206 | bile acid metabolic process | 8486699 |
Tgene | AKR1C1 | GO:0030855 | epithelial cell differentiation | 21492153 |
Tgene | AKR1C1 | GO:0042448 | progesterone metabolic process | 21232532 |
Tgene | AKR1C1 | GO:0042574 | retinal metabolic process | 21851338 |
Tgene | AKR1C1 | GO:0055114 | oxidation-reduction process | 8486699|19442656|21232532 |
Tgene | AKR1C1 | GO:0071395 | cellular response to jasmonic acid stimulus | 19487289 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BLCA | TCGA-FD-A43N-01A | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
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Fusion Gene ORF analysis for C6orf136-AKR1C1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000293604 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
5CDS-3UTR | ENST00000293604 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
5CDS-3UTR | ENST00000293604 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
5CDS-3UTR | ENST00000376473 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
5CDS-3UTR | ENST00000376473 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
5CDS-3UTR | ENST00000376473 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
5CDS-3UTR | ENST00000528347 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
5CDS-3UTR | ENST00000528347 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
5CDS-3UTR | ENST00000528347 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
In-frame | ENST00000293604 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
In-frame | ENST00000376473 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
In-frame | ENST00000528347 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000376471 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000383580 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000383581 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000415931 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000417076 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000417649 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000419321 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000422530 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000425581 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000430141 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000447505 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000455682 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000456444 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000459700 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000466518 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000472341 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000486177 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000491140 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000493705 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000496234 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000546452 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000547308 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000549361 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000549800 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000549861 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3CDS | ENST00000552569 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000376471 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000376471 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000376471 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000383580 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000383580 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000383580 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000383581 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000383581 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000383581 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000415931 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000415931 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000415931 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000417076 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000417076 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000417076 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000417649 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000417649 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000417649 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000419321 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000419321 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000419321 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000422530 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000422530 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000422530 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000425581 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000425581 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000425581 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000430141 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000430141 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000430141 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000447505 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000447505 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000447505 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000455682 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000455682 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000455682 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000456444 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000456444 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000456444 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000459700 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000459700 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000459700 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000466518 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000466518 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000466518 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000472341 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000472341 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000472341 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000486177 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000486177 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000486177 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000491140 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000491140 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000491140 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000493705 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000493705 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000493705 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000496234 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000496234 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000496234 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000546452 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000546452 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000546452 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000547308 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000547308 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000547308 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000549361 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000549361 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000549361 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000549800 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000549800 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000549800 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000549861 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000549861 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000549861 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000552569 | ENST00000380859 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000552569 | ENST00000380872 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
intron-3UTR | ENST00000552569 | ENST00000477661 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000293604 | C6orf136 | chr6 | 30617736 | + | ENST00000434459 | AKR1C1 | chr10 | 5008106 | + | 2306 | 1210 | 193 | 2097 | 634 |
ENST00000376473 | C6orf136 | chr6 | 30617736 | + | ENST00000434459 | AKR1C1 | chr10 | 5008106 | + | 1729 | 633 | 159 | 1520 | 453 |
ENST00000528347 | C6orf136 | chr6 | 30617736 | + | ENST00000434459 | AKR1C1 | chr10 | 5008106 | + | 1141 | 45 | 0 | 932 | 310 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000293604 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + | 0.025779415 | 0.9742206 |
ENST00000376473 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + | 0.011699325 | 0.9883007 |
ENST00000528347 | ENST00000434459 | C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008106 | + | 0.001260956 | 0.99873906 |
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Fusion Genomic Features for C6orf136-AKR1C1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008105 | + | 0.015799576 | 0.9842004 |
C6orf136 | chr6 | 30617736 | + | AKR1C1 | chr10 | 5008105 | + | 0.015799576 | 0.9842004 |
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Fusion Protein Features for C6orf136-AKR1C1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:30617736/chr10:5008106) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
C6orf136 | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | AKR1C1 | chr6:30617736 | chr10:5008106 | ENST00000380872 | 0 | 9 | 166_167 | 28 | 324.0 | Nucleotide binding | NADP | |
Tgene | AKR1C1 | chr6:30617736 | chr10:5008106 | ENST00000380872 | 0 | 9 | 216_222 | 28 | 324.0 | Nucleotide binding | NADP | |
Tgene | AKR1C1 | chr6:30617736 | chr10:5008106 | ENST00000380872 | 0 | 9 | 270_280 | 28 | 324.0 | Nucleotide binding | NADP | |
Tgene | AKR1C1 | chr6:30617736 | chr10:5008106 | ENST00000434459 | 5 | 14 | 166_167 | 28 | 324.0 | Nucleotide binding | NADP | |
Tgene | AKR1C1 | chr6:30617736 | chr10:5008106 | ENST00000434459 | 5 | 14 | 216_222 | 28 | 324.0 | Nucleotide binding | NADP | |
Tgene | AKR1C1 | chr6:30617736 | chr10:5008106 | ENST00000434459 | 5 | 14 | 270_280 | 28 | 324.0 | Nucleotide binding | NADP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | AKR1C1 | chr6:30617736 | chr10:5008106 | ENST00000380872 | 0 | 9 | 20_24 | 28 | 324.0 | Nucleotide binding | NADP | |
Tgene | AKR1C1 | chr6:30617736 | chr10:5008106 | ENST00000434459 | 5 | 14 | 20_24 | 28 | 324.0 | Nucleotide binding | NADP |
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Fusion Gene Sequence for C6orf136-AKR1C1 |
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>11925_11925_1_C6orf136-AKR1C1_C6orf136_chr6_30617736_ENST00000293604_AKR1C1_chr10_5008106_ENST00000434459_length(transcript)=2306nt_BP=1210nt CTTCAGCCGCTTCCCTCGAGCCTGCAGTGCGCAAGCGCGGGACATCTCCGTTTCCCTCCCTCAGCCCCTTCCCCCCCTACCCCCCCGCCC CGGCCTCCTTTCCCCTTCACGAAGCCGGCTCTGGGGCGCGCTCACCCCTGTGAGGAGGCCGGAGGTCGGACTCAGGAGGCTCCTTCTCCA CTCCCGGAAGATCATGTACCAGCCCAGCCGGGGTGCGGCCCGGCGTCTCGGCCCTTGCCTGCGCGCCTACCAGGCTCGACCCCAGGTGAG CGGAGGAGAAGAGGGAGGGAGGAGAGGGGGCGGGGAGAGACCCTCCTCAAAGCCGGTGCGTGGGGCGGAGCGCGCGCTGGGTTCCGCGCA GGCGCAGAGACACCCGCCGCCCCTTCCCACCTGTGCCCTGCAGCGCGTGGACAGGCTAGGGGTCGCGGGAGCGGGAGGGAGGCGCTGCCG GGCCTGTCGCGCAAGGACGTCGGTCCTCCCAGGTTTGAGGGCGGTCAGGCGGGGTCAAGGCCAGGCAGCGGGGCGCGTCTGCGTTGCGCC CGACTCTCCGCGGTTACCTGTGCCTAGAGGTGATTTGAAGGGCAGGGGCCGAGAGATTCGTAGCCCTGCTGCGGCGCCGTCCCGGAGTTC CCCGGCCCAGACCAGACCCGCGGGGCGCCCTCAGCAGCCCGCCCGTCTTGCACTCGGAGAGCGGTCCTGGCAGGAAGGCCGGCCAGTGTG CACCCGGTTCGGGCCCCTGCGCCCGGGCTGGCAAGATGGCCACGCCCCCAGCAGAGACGGCGCCTCTAGGACACCATCGGGGACCGAGGA CCAGCTTTATCCAGGGACTCTACCATTCCCACCCCTTTGGCCCCACTCCACGACAACCACTTCCCCATCTTCTCCTCTATTCTGGTCTCC CCTGCCCCCACGCCTTCCCACCCAGCGTCTTCCCCAGGTTCCCCCACTACCTCTCCCTCAGATCCAGGCCCTCAGCTCAGCATGGGTGGT TCTCCCTCCAGGAAAGGGGGAGGAGGGACCAGGACCTGAGTTGCATAGCGGCTGCCTGGATGGGCTTAGAAGCCTTTTTGAGGGACCTCC CTGCCCCTATCCTGGGGCTTGGATACCTTTCCAAGTCCCTGGAACTGCCCACCCTTCCCCTGCCACCCCGTCAGGAGATCCTAGTATGGA GGAACATCTGTCTGTCATGTATGAGAGACTGAGACAAGAGGTTCCTAAAAGTAAAGCTTTAGAGGCCACCAAATTGGCAATTGAAGCTGG CTTCCGCCATATTGATTCTGCTCATTTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAA GAGAGAAGACATATTCTACACTTCAAAGCTTTGGTGCAATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAGGTCACTGAAAAA TCTTCAATTGGATTATGTTGACCTCTACCTTATTCATTTTCCAGTGTCTGTAAAGCCAGGTGAGGAAGTGATCCCAAAAGATGAAAATGG AAAAATACTATTTGACACAGTGGATCTCTGTGCCACATGGGAGGCCGTGGAGAAGTGTAAAGATGCAGGATTGGCCAAGTCCATCGGGGT GTCCAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCAGGGCTCAAGTACAAGCCTGTCTGCAACCAGGTGGAATGTCATCC TTACTTCAACCAGAGAAAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCTATAGTGCTCTGGGATCCCACCGAGAAGA ACCATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTCCTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGAT TGCCCTGCGCTACCAGCTACAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAACGTGCAGGTGTTTGA ATTCCAGTTGACTTCAGAGGAGATGAAAGCCATAGATGGCCTAAACAGAAATGTGCGATATTTGACCCTTGATATTTTTGCTGGCCCCCC TAATTATCCATTTTCTGATGAATATTAACATGGAGGGCATTGCATGAGGTCTGCCAGAAGGCCCTGCGTGTGGATGGTGACACAGAGGAT GGCTCTATGCTGGTGACTGGACACATCGCCTCTGGTTAAATCTCTCCTGCTTGGTGATTTCAGCAAGCTACAGCAAAGCCCATTGGCCAG >11925_11925_1_C6orf136-AKR1C1_C6orf136_chr6_30617736_ENST00000293604_AKR1C1_chr10_5008106_ENST00000434459_length(amino acids)=634AA_BP=346 MYQPSRGAARRLGPCLRAYQARPQVSGGEEGGRRGGGERPSSKPVRGAERALGSAQAQRHPPPLPTCALQRVDRLGVAGAGGRRCRACRA RTSVLPGLRAVRRGQGQAAGRVCVAPDSPRLPVPRGDLKGRGREIRSPAAAPSRSSPAQTRPAGRPQQPARLALGERSWQEGRPVCTRFG PLRPGWQDGHAPSRDGASRTPSGTEDQLYPGTLPFPPLWPHSTTTTSPSSPLFWSPLPPRLPTQRLPQVPPLPLPQIQALSSAWVVLPPG KGEEGPGPELHSGCLDGLRSLFEGPPCPYPGAWIPFQVPGTAHPSPATPSGDPSMEEHLSVMYERLRQEVPKSKALEATKLAIEAGFRHI DSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILF DTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVD PNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPF -------------------------------------------------------------- >11925_11925_2_C6orf136-AKR1C1_C6orf136_chr6_30617736_ENST00000376473_AKR1C1_chr10_5008106_ENST00000434459_length(transcript)=1729nt_BP=633nt GCGCGGGACATCTCCGTTTCCCTCCCTCAGCCCCTTCCCCCCCTACCCCCCCGCCCCGGCCTCCTTTCCCCTTCACGAAGCCGGCTCTGG GGCGCGCTCACCCCTGTGAGGAGGCCGGAGGTCGGACTCAGGAGGCTCCTTCTCCACTCCCGGAAGATCATGTACCAGCCCAGCCGGGGT GCGGCCCGGCGTCTCGGCCCTTGCCTGCGCGCCTACCAGGCTCGACCCCAGGACCAGCTTTATCCAGGGACTCTACCATTCCCACCCCTT TGGCCCCACTCCACGACAACCACTTCCCCATCTTCTCCTCTATTCTGGTCTCCCCTGCCCCCACGCCTTCCCACCCAGCGTCTTCCCCAG GTTCCCCCACTACCTCTCCCTCAGATCCAGGCCCTCAGCTCAGCATGGGTGGTTCTCCCTCCAGGAAAGGGGGAGGAGGGACCAGGACCT GAGTTGCATAGCGGCTGCCTGGATGGGCTTAGAAGCCTTTTTGAGGGACCTCCCTGCCCCTATCCTGGGGCTTGGATACCTTTCCAAGTC CCTGGAACTGCCCACCCTTCCCCTGCCACCCCGTCAGGAGATCCTAGTATGGAGGAACATCTGTCTGTCATGTATGAGAGACTGAGACAA GAGGTTCCTAAAAGTAAAGCTTTAGAGGCCACCAAATTGGCAATTGAAGCTGGCTTCCGCCATATTGATTCTGCTCATTTATACAATAAT GAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTCAAAGCTTTGGTGC AATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAGGTCACTGAAAAATCTTCAATTGGATTATGTTGACCTCTACCTTATTCAT TTTCCAGTGTCTGTAAAGCCAGGTGAGGAAGTGATCCCAAAAGATGAAAATGGAAAAATACTATTTGACACAGTGGATCTCTGTGCCACA TGGGAGGCCGTGGAGAAGTGTAAAGATGCAGGATTGGCCAAGTCCATCGGGGTGTCCAACTTCAACCGCAGGCAGCTGGAGATGATCCTC AACAAGCCAGGGCTCAAGTACAAGCCTGTCTGCAACCAGGTGGAATGTCATCCTTACTTCAACCAGAGAAAACTGCTGGATTTCTGCAAG TCAAAAGACATTGTTCTGGTTGCCTATAGTGCTCTGGGATCCCACCGAGAAGAACCATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAG GACCCAGTCCTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAGCTACAGCGTGGGGTTGTGGTC CTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAACGTGCAGGTGTTTGAATTCCAGTTGACTTCAGAGGAGATGAAAGCCATAGAT GGCCTAAACAGAAATGTGCGATATTTGACCCTTGATATTTTTGCTGGCCCCCCTAATTATCCATTTTCTGATGAATATTAACATGGAGGG CATTGCATGAGGTCTGCCAGAAGGCCCTGCGTGTGGATGGTGACACAGAGGATGGCTCTATGCTGGTGACTGGACACATCGCCTCTGGTT AAATCTCTCCTGCTTGGTGATTTCAGCAAGCTACAGCAAAGCCCATTGGCCAGAAAGGAAAGACAATAATTTTGTTTTTTCATTTTGAAA >11925_11925_2_C6orf136-AKR1C1_C6orf136_chr6_30617736_ENST00000376473_AKR1C1_chr10_5008106_ENST00000434459_length(amino acids)=453AA_BP=165 MYQPSRGAARRLGPCLRAYQARPQDQLYPGTLPFPPLWPHSTTTTSPSSPLFWSPLPPRLPTQRLPQVPPLPLPQIQALSSAWVVLPPGK GEEGPGPELHSGCLDGLRSLFEGPPCPYPGAWIPFQVPGTAHPSPATPSGDPSMEEHLSVMYERLRQEVPKSKALEATKLAIEAGFRHID SAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFD TVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDP NSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFS -------------------------------------------------------------- >11925_11925_3_C6orf136-AKR1C1_C6orf136_chr6_30617736_ENST00000528347_AKR1C1_chr10_5008106_ENST00000434459_length(transcript)=1141nt_BP=45nt ATGGAGGAACATCTGTCTGTCATGTATGAGAGACTGAGACAAGAGGTTCCTAAAAGTAAAGCTTTAGAGGCCACCAAATTGGCAATTGAA GCTGGCTTCCGCCATATTGATTCTGCTCATTTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGT GTGAAGAGAGAAGACATATTCTACACTTCAAAGCTTTGGTGCAATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAGGTCACTG AAAAATCTTCAATTGGATTATGTTGACCTCTACCTTATTCATTTTCCAGTGTCTGTAAAGCCAGGTGAGGAAGTGATCCCAAAAGATGAA AATGGAAAAATACTATTTGACACAGTGGATCTCTGTGCCACATGGGAGGCCGTGGAGAAGTGTAAAGATGCAGGATTGGCCAAGTCCATC GGGGTGTCCAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCAGGGCTCAAGTACAAGCCTGTCTGCAACCAGGTGGAATGT CATCCTTACTTCAACCAGAGAAAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCTATAGTGCTCTGGGATCCCACCGA GAAGAACCATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTCCTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCC CTGATTGCCCTGCGCTACCAGCTACAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAACGTGCAGGTG TTTGAATTCCAGTTGACTTCAGAGGAGATGAAAGCCATAGATGGCCTAAACAGAAATGTGCGATATTTGACCCTTGATATTTTTGCTGGC CCCCCTAATTATCCATTTTCTGATGAATATTAACATGGAGGGCATTGCATGAGGTCTGCCAGAAGGCCCTGCGTGTGGATGGTGACACAG AGGATGGCTCTATGCTGGTGACTGGACACATCGCCTCTGGTTAAATCTCTCCTGCTTGGTGATTTCAGCAAGCTACAGCAAAGCCCATTG >11925_11925_3_C6orf136-AKR1C1_C6orf136_chr6_30617736_ENST00000528347_AKR1C1_chr10_5008106_ENST00000434459_length(amino acids)=310AA_BP=22 MEEHLSVMYERLRQEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSL KNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVEC HPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for C6orf136-AKR1C1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for C6orf136-AKR1C1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for C6orf136-AKR1C1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human | |
Tgene | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human | |
Tgene | C0014170 | Endometrial Neoplasms | 1 | CTD_human | |
Tgene | C0014175 | Endometriosis | 1 | CTD_human | |
Tgene | C0019269 | Hermaphroditism | 1 | CTD_human | |
Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
Tgene | C0027661 | Neoplasms, Hormone-Dependent | 1 | CTD_human | |
Tgene | C0029408 | Degenerative polyarthritis | 1 | CTD_human | |
Tgene | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human | |
Tgene | C0033804 | Pseudohermaphroditism | 1 | CTD_human | |
Tgene | C0036875 | Disorders of Sex Development | 1 | CTD_human | |
Tgene | C0086743 | Osteoarthrosis Deformans | 1 | CTD_human | |
Tgene | C0266362 | Ambiguous Genitalia | 1 | CTD_human | |
Tgene | C0269102 | Endometrioma | 1 | CTD_human | |
Tgene | C0476089 | Endometrial Carcinoma | 1 | CTD_human | |
Tgene | C1136382 | Sclerocystic Ovaries | 1 | CTD_human | |
Tgene | C2930618 | Intersex Conditions | 1 | CTD_human | |
Tgene | C2930619 | Sex Differentiation Disorders | 1 | CTD_human |