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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALDH9A1-NME7 (FusionGDB2 ID:HG223TG29922)

Fusion Gene Summary for ALDH9A1-NME7

check button Fusion gene summary
Fusion gene informationFusion gene name: ALDH9A1-NME7
Fusion gene ID: hg223tg29922
HgeneTgene
Gene symbol

ALDH9A1

NME7

Gene ID

223

29922

Gene namealdehyde dehydrogenase 9 family member A1NME/NM23 family member 7
SynonymsALDH4|ALDH7|ALDH9|E3|TMABA-DH|TMABADH|TMABALDHCFAP67|MN23H7|NDK 7|NDK7|nm23-H7
Cytomap('ALDH9A1')('NME7')

1q24.1

1q24.2

Type of geneprotein-codingprotein-coding
Description4-trimethylaminobutyraldehyde dehydrogenaseR-aminobutyraldehyde dehydrogenasealdehyde dehydrogenase (NAD+)aldehyde dehydrogenase E3 isozymealdehyde dehydrogenase family 9 member A1gamma-aminobutyraldehyde dehydrogenasenucleoside diphosphate kinase 7NDP kinase 7cilia and flagella associated protein 67non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)
Modification date2020031320200327
UniProtAcc.

Q9Y5B8

Ensembl transtripts involved in fusion geneENST00000354775, ENST00000538148, 
ENST00000461664, 
Fusion gene scores* DoF score5 X 7 X 4=14012 X 9 X 7=756
# samples 613
** MAII scorelog2(6/140*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/756*10)=-2.53987461119262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALDH9A1 [Title/Abstract] AND NME7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALDH9A1(165651344)-NME7(169206925), # samples:3
Anticipated loss of major functional domain due to fusion event.ALDH9A1-NME7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALDH9A1-NME7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ALDH9A1-NME7 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ALDH9A1-NME7 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ALDH9A1-NME7 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ALDH9A1-NME7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALDH9A1

GO:0006081

cellular aldehyde metabolic process

8645224|30914451

HgeneALDH9A1

GO:0042136

neurotransmitter biosynthetic process

2925663

HgeneALDH9A1

GO:0051289

protein homotetramerization

30914451

HgeneALDH9A1

GO:0055114

oxidation-reduction process

2925663


check buttonFusion gene breakpoints across ALDH9A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NME7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-86-8673-01AALDH9A1chr1

165651344

-NME7chr1

169206925

-


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Fusion Gene ORF analysis for ALDH9A1-NME7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000354775ENST00000469474ALDH9A1chr1

165651344

-NME7chr1

169206925

-
5CDS-intronENST00000538148ENST00000469474ALDH9A1chr1

165651344

-NME7chr1

169206925

-
5UTR-3CDSENST00000461664ENST00000367811ALDH9A1chr1

165651344

-NME7chr1

169206925

-
5UTR-3CDSENST00000461664ENST00000472647ALDH9A1chr1

165651344

-NME7chr1

169206925

-
5UTR-intronENST00000461664ENST00000469474ALDH9A1chr1

165651344

-NME7chr1

169206925

-
Frame-shiftENST00000538148ENST00000367811ALDH9A1chr1

165651344

-NME7chr1

169206925

-
Frame-shiftENST00000538148ENST00000472647ALDH9A1chr1

165651344

-NME7chr1

169206925

-
In-frameENST00000354775ENST00000367811ALDH9A1chr1

165651344

-NME7chr1

169206925

-
In-frameENST00000354775ENST00000472647ALDH9A1chr1

165651344

-NME7chr1

169206925

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000354775ALDH9A1chr1165651344-ENST00000472647NME7chr1169206925-15288972001273357
ENST00000354775ALDH9A1chr1165651344-ENST00000367811NME7chr1169206925-15288972001273357

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354775ENST00000472647ALDH9A1chr1165651344-NME7chr1169206925-0.0007361340.9992638
ENST00000354775ENST00000367811ALDH9A1chr1165651344-NME7chr1169206925-0.0007361340.9992638

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Fusion Genomic Features for ALDH9A1-NME7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ALDH9A1-NME7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:165651344/chr1:169206925)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NME7

Q9Y5B8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALDH9A1chr1:165651344chr1:169206925ENST00000354775-411232_236197519.0Nucleotide bindingNAD
TgeneNME7chr1:165651344chr1:169206925ENST000003678116123_91251377.0DomainDM10
TgeneNME7chr1:165651344chr1:169206925ENST000004726476123_91215341.0DomainDM10


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Fusion Gene Sequence for ALDH9A1-NME7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3928_3928_1_ALDH9A1-NME7_ALDH9A1_chr1_165651344_ENST00000354775_NME7_chr1_169206925_ENST00000367811_length(transcript)=1528nt_BP=897nt
GGATCCTAGGATGCTTACATGCAATGATGAACCCGAAAACACTTGCAAAGTGCTACGCAAATATTGATCACGAAGAAGGAAGTCCTCTTC
CCGCCTGGAGACTGTGTGGGGTATGGCGGGGTGGTGGGGAGAATGTGGTGTCTTGCTCCACCCTCCTGGCGAGGGGAGGGCCTGGCCTGG
ACCGCAGAGGAATCGAGTGACTGCCCCTAAAATCTCCTAGAACCGATCCCGCGGCCCCGCCCCTCCCGCGGCCCCGCCCCTCCCGCGGCC
CGTCAGCCTCTGCCGCGGAGCTGCGTCCGCCACTCATGTTTCTCCGAGCAGGCCTGGCCGCGCTCTCCCCGCTTCTTCGCAGTCTTCGGC
CCTCTCCTGTCGCCGCCATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCCGCGTGGAGCCGGCGGACG
CCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATAGCTACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTG
TTCAAAATGCAAAGGCTGCTTTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCTGCCAGGATAATAA
GGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGCAAGTCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGC
AGTGCCTGGAGTATTATGCGGGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGTTATACCAGAAGAG
AACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTTCAGATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGAC
TGTTGGGAAAGATCCTGATGGCTATCCGAGATGCAGGTTTTGAAATCTCAGCTATGCAGATGTTCAATATGGATCGGGTTAATGTTGAGG
AATTCTATGAAGTTTATAAAGGAGTAGTGACCGAATATCATGACATGGTGACAGAAATGTATTCTGGCCCTTGTGTAGCAATGGAGATTC
AACAGAATAATGCTACAAAGACATTTCGAGAATTTTGTGGACCTGCTGATCCTGAAATTGCCCGGCATTTACGCCCTGGAACTCTCAGAG
CAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCAGAGGATGGCCTATTAGAGGTTCAATACTTCTTCAAGA
TCTTGGATAATTAGTGGTGTGGAAAGTAAAGAAGTCACAGGTTGGGACATTTAGACAAGAGTGAATCACACACGAGGAATGTGTTCATTC
TTTTATTGTCCGTTGTTTTAACCTGACTGAATACAAGATCAACAAGAGCACTGTACTCCTGGCAATTATTACATATGTTAGAACATGGAT

>3928_3928_1_ALDH9A1-NME7_ALDH9A1_chr1_165651344_ENST00000354775_NME7_chr1_169206925_ENST00000367811_length(amino acids)=357AA_BP=232
MPLKSPRTDPAAPPLPRPRPSRGPSASAAELRPPLMFLRAGLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTEKA
FEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYA
GLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYK

--------------------------------------------------------------
>3928_3928_2_ALDH9A1-NME7_ALDH9A1_chr1_165651344_ENST00000354775_NME7_chr1_169206925_ENST00000472647_length(transcript)=1528nt_BP=897nt
GGATCCTAGGATGCTTACATGCAATGATGAACCCGAAAACACTTGCAAAGTGCTACGCAAATATTGATCACGAAGAAGGAAGTCCTCTTC
CCGCCTGGAGACTGTGTGGGGTATGGCGGGGTGGTGGGGAGAATGTGGTGTCTTGCTCCACCCTCCTGGCGAGGGGAGGGCCTGGCCTGG
ACCGCAGAGGAATCGAGTGACTGCCCCTAAAATCTCCTAGAACCGATCCCGCGGCCCCGCCCCTCCCGCGGCCCCGCCCCTCCCGCGGCC
CGTCAGCCTCTGCCGCGGAGCTGCGTCCGCCACTCATGTTTCTCCGAGCAGGCCTGGCCGCGCTCTCCCCGCTTCTTCGCAGTCTTCGGC
CCTCTCCTGTCGCCGCCATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCCGCGTGGAGCCGGCGGACG
CCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATAGCTACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTG
TTCAAAATGCAAAGGCTGCTTTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCTGCCAGGATAATAA
GGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGCAAGTCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGC
AGTGCCTGGAGTATTATGCGGGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGTTATACCAGAAGAG
AACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTTCAGATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGAC
TGTTGGGAAAGATCCTGATGGCTATCCGAGATGCAGGTTTTGAAATCTCAGCTATGCAGATGTTCAATATGGATCGGGTTAATGTTGAGG
AATTCTATGAAGTTTATAAAGGAGTAGTGACCGAATATCATGACATGGTGACAGAAATGTATTCTGGCCCTTGTGTAGCAATGGAGATTC
AACAGAATAATGCTACAAAGACATTTCGAGAATTTTGTGGACCTGCTGATCCTGAAATTGCCCGGCATTTACGCCCTGGAACTCTCAGAG
CAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCAGAGGATGGCCTATTAGAGGTTCAATACTTCTTCAAGA
TCTTGGATAATTAGTGGTGTGGAAAGTAAAGAAGTCACAGGTTGGGACATTTAGACAAGAGTGAATCACACACGAGGAATGTGTTCATTC
TTTTATTGTCCGTTGTTTTAACCTGACTGAATACAAGATCAACAAGAGCACTGTACTCCTGGCAATTATTACATATGTTAGAACATGGAT

>3928_3928_2_ALDH9A1-NME7_ALDH9A1_chr1_165651344_ENST00000354775_NME7_chr1_169206925_ENST00000472647_length(amino acids)=357AA_BP=232
MPLKSPRTDPAAPPLPRPRPSRGPSASAAELRPPLMFLRAGLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTEKA
FEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYA
GLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ALDH9A1-NME7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALDH9A1-NME7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ALDH9A1-NME7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALDH9A1C0019193Hepatitis, Toxic1CTD_human
HgeneALDH9A1C0860207Drug-Induced Liver Disease1CTD_human
HgeneALDH9A1C1262760Hepatitis, Drug-Induced1CTD_human
HgeneALDH9A1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneALDH9A1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneALDH9A1C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC0013146Drug abuse1CTD_human
TgeneC0013170Drug habituation1CTD_human
TgeneC0013222Drug Use Disorders1CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneC0037221Situs Inversus1ORPHANET
TgeneC0038580Substance Dependence1CTD_human
TgeneC0038586Substance Use Disorders1CTD_human
TgeneC0236969Substance-Related Disorders1CTD_human
TgeneC0238198Gastrointestinal Stromal Tumors1CTD_human
TgeneC0740858Substance abuse problem1CTD_human
TgeneC1510472Drug Dependence1CTD_human
TgeneC3179349Gastrointestinal Stromal Sarcoma1CTD_human
TgeneC4316881Prescription Drug Abuse1CTD_human