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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ALDH9A1-NME7 (FusionGDB2 ID:HG223TG29922) |
Fusion Gene Summary for ALDH9A1-NME7 |
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Fusion gene information | Fusion gene name: ALDH9A1-NME7 | Fusion gene ID: hg223tg29922 | Hgene | Tgene | Gene symbol | ALDH9A1 | NME7 | Gene ID | 223 | 29922 |
Gene name | aldehyde dehydrogenase 9 family member A1 | NME/NM23 family member 7 | |
Synonyms | ALDH4|ALDH7|ALDH9|E3|TMABA-DH|TMABADH|TMABALDH | CFAP67|MN23H7|NDK 7|NDK7|nm23-H7 | |
Cytomap | ('ALDH9A1')('NME7') 1q24.1 | 1q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | 4-trimethylaminobutyraldehyde dehydrogenaseR-aminobutyraldehyde dehydrogenasealdehyde dehydrogenase (NAD+)aldehyde dehydrogenase E3 isozymealdehyde dehydrogenase family 9 member A1gamma-aminobutyraldehyde dehydrogenase | nucleoside diphosphate kinase 7NDP kinase 7cilia and flagella associated protein 67non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | . | Q9Y5B8 | |
Ensembl transtripts involved in fusion gene | ENST00000354775, ENST00000538148, ENST00000461664, | ||
Fusion gene scores | * DoF score | 5 X 7 X 4=140 | 12 X 9 X 7=756 |
# samples | 6 | 13 | |
** MAII score | log2(6/140*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/756*10)=-2.53987461119262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ALDH9A1 [Title/Abstract] AND NME7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ALDH9A1(165651344)-NME7(169206925), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | ALDH9A1-NME7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALDH9A1-NME7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ALDH9A1-NME7 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ALDH9A1-NME7 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ALDH9A1-NME7 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ALDH9A1-NME7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ALDH9A1 | GO:0006081 | cellular aldehyde metabolic process | 8645224|30914451 |
Hgene | ALDH9A1 | GO:0042136 | neurotransmitter biosynthetic process | 2925663 |
Hgene | ALDH9A1 | GO:0051289 | protein homotetramerization | 30914451 |
Hgene | ALDH9A1 | GO:0055114 | oxidation-reduction process | 2925663 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUAD | TCGA-86-8673-01A | ALDH9A1 | chr1 | 165651344 | - | NME7 | chr1 | 169206925 | - |
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Fusion Gene ORF analysis for ALDH9A1-NME7 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000354775 | ENST00000469474 | ALDH9A1 | chr1 | 165651344 | - | NME7 | chr1 | 169206925 | - |
5CDS-intron | ENST00000538148 | ENST00000469474 | ALDH9A1 | chr1 | 165651344 | - | NME7 | chr1 | 169206925 | - |
5UTR-3CDS | ENST00000461664 | ENST00000367811 | ALDH9A1 | chr1 | 165651344 | - | NME7 | chr1 | 169206925 | - |
5UTR-3CDS | ENST00000461664 | ENST00000472647 | ALDH9A1 | chr1 | 165651344 | - | NME7 | chr1 | 169206925 | - |
5UTR-intron | ENST00000461664 | ENST00000469474 | ALDH9A1 | chr1 | 165651344 | - | NME7 | chr1 | 169206925 | - |
Frame-shift | ENST00000538148 | ENST00000367811 | ALDH9A1 | chr1 | 165651344 | - | NME7 | chr1 | 169206925 | - |
Frame-shift | ENST00000538148 | ENST00000472647 | ALDH9A1 | chr1 | 165651344 | - | NME7 | chr1 | 169206925 | - |
In-frame | ENST00000354775 | ENST00000367811 | ALDH9A1 | chr1 | 165651344 | - | NME7 | chr1 | 169206925 | - |
In-frame | ENST00000354775 | ENST00000472647 | ALDH9A1 | chr1 | 165651344 | - | NME7 | chr1 | 169206925 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000354775 | ALDH9A1 | chr1 | 165651344 | - | ENST00000472647 | NME7 | chr1 | 169206925 | - | 1528 | 897 | 200 | 1273 | 357 |
ENST00000354775 | ALDH9A1 | chr1 | 165651344 | - | ENST00000367811 | NME7 | chr1 | 169206925 | - | 1528 | 897 | 200 | 1273 | 357 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000354775 | ENST00000472647 | ALDH9A1 | chr1 | 165651344 | - | NME7 | chr1 | 169206925 | - | 0.000736134 | 0.9992638 |
ENST00000354775 | ENST00000367811 | ALDH9A1 | chr1 | 165651344 | - | NME7 | chr1 | 169206925 | - | 0.000736134 | 0.9992638 |
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Fusion Genomic Features for ALDH9A1-NME7 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ALDH9A1-NME7 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:165651344/chr1:169206925) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | NME7 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ALDH9A1 | chr1:165651344 | chr1:169206925 | ENST00000354775 | - | 4 | 11 | 232_236 | 197 | 519.0 | Nucleotide binding | NAD |
Tgene | NME7 | chr1:165651344 | chr1:169206925 | ENST00000367811 | 6 | 12 | 3_91 | 251 | 377.0 | Domain | DM10 | |
Tgene | NME7 | chr1:165651344 | chr1:169206925 | ENST00000472647 | 6 | 12 | 3_91 | 215 | 341.0 | Domain | DM10 |
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Fusion Gene Sequence for ALDH9A1-NME7 |
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>3928_3928_1_ALDH9A1-NME7_ALDH9A1_chr1_165651344_ENST00000354775_NME7_chr1_169206925_ENST00000367811_length(transcript)=1528nt_BP=897nt GGATCCTAGGATGCTTACATGCAATGATGAACCCGAAAACACTTGCAAAGTGCTACGCAAATATTGATCACGAAGAAGGAAGTCCTCTTC CCGCCTGGAGACTGTGTGGGGTATGGCGGGGTGGTGGGGAGAATGTGGTGTCTTGCTCCACCCTCCTGGCGAGGGGAGGGCCTGGCCTGG ACCGCAGAGGAATCGAGTGACTGCCCCTAAAATCTCCTAGAACCGATCCCGCGGCCCCGCCCCTCCCGCGGCCCCGCCCCTCCCGCGGCC CGTCAGCCTCTGCCGCGGAGCTGCGTCCGCCACTCATGTTTCTCCGAGCAGGCCTGGCCGCGCTCTCCCCGCTTCTTCGCAGTCTTCGGC CCTCTCCTGTCGCCGCCATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCCGCGTGGAGCCGGCGGACG CCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATAGCTACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTG TTCAAAATGCAAAGGCTGCTTTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCTGCCAGGATAATAA GGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGCAAGTCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGC AGTGCCTGGAGTATTATGCGGGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGTTATACCAGAAGAG AACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTTCAGATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGAC TGTTGGGAAAGATCCTGATGGCTATCCGAGATGCAGGTTTTGAAATCTCAGCTATGCAGATGTTCAATATGGATCGGGTTAATGTTGAGG AATTCTATGAAGTTTATAAAGGAGTAGTGACCGAATATCATGACATGGTGACAGAAATGTATTCTGGCCCTTGTGTAGCAATGGAGATTC AACAGAATAATGCTACAAAGACATTTCGAGAATTTTGTGGACCTGCTGATCCTGAAATTGCCCGGCATTTACGCCCTGGAACTCTCAGAG CAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCAGAGGATGGCCTATTAGAGGTTCAATACTTCTTCAAGA TCTTGGATAATTAGTGGTGTGGAAAGTAAAGAAGTCACAGGTTGGGACATTTAGACAAGAGTGAATCACACACGAGGAATGTGTTCATTC TTTTATTGTCCGTTGTTTTAACCTGACTGAATACAAGATCAACAAGAGCACTGTACTCCTGGCAATTATTACATATGTTAGAACATGGAT TTTGCACTGTAGACAACATTTAACACCAGTCTATGGGGTACTGCATTGCTTTTTATAAAGTTCAAAATAAAGATTTATTTTCAAACAA >3928_3928_1_ALDH9A1-NME7_ALDH9A1_chr1_165651344_ENST00000354775_NME7_chr1_169206925_ENST00000367811_length(amino acids)=357AA_BP=232 MPLKSPRTDPAAPPLPRPRPSRGPSASAAELRPPLMFLRAGLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTEKA FEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYA GLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYK GVVTEYHDMVTEMYSGPCVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFKILDN -------------------------------------------------------------- >3928_3928_2_ALDH9A1-NME7_ALDH9A1_chr1_165651344_ENST00000354775_NME7_chr1_169206925_ENST00000472647_length(transcript)=1528nt_BP=897nt GGATCCTAGGATGCTTACATGCAATGATGAACCCGAAAACACTTGCAAAGTGCTACGCAAATATTGATCACGAAGAAGGAAGTCCTCTTC CCGCCTGGAGACTGTGTGGGGTATGGCGGGGTGGTGGGGAGAATGTGGTGTCTTGCTCCACCCTCCTGGCGAGGGGAGGGCCTGGCCTGG ACCGCAGAGGAATCGAGTGACTGCCCCTAAAATCTCCTAGAACCGATCCCGCGGCCCCGCCCCTCCCGCGGCCCCGCCCCTCCCGCGGCC CGTCAGCCTCTGCCGCGGAGCTGCGTCCGCCACTCATGTTTCTCCGAGCAGGCCTGGCCGCGCTCTCCCCGCTTCTTCGCAGTCTTCGGC CCTCTCCTGTCGCCGCCATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCCGCGTGGAGCCGGCGGACG CCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATAGCTACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTG TTCAAAATGCAAAGGCTGCTTTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCTGCCAGGATAATAA GGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGCAAGTCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGC AGTGCCTGGAGTATTATGCGGGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGTTATACCAGAAGAG AACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTTCAGATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGAC TGTTGGGAAAGATCCTGATGGCTATCCGAGATGCAGGTTTTGAAATCTCAGCTATGCAGATGTTCAATATGGATCGGGTTAATGTTGAGG AATTCTATGAAGTTTATAAAGGAGTAGTGACCGAATATCATGACATGGTGACAGAAATGTATTCTGGCCCTTGTGTAGCAATGGAGATTC AACAGAATAATGCTACAAAGACATTTCGAGAATTTTGTGGACCTGCTGATCCTGAAATTGCCCGGCATTTACGCCCTGGAACTCTCAGAG CAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCAGAGGATGGCCTATTAGAGGTTCAATACTTCTTCAAGA TCTTGGATAATTAGTGGTGTGGAAAGTAAAGAAGTCACAGGTTGGGACATTTAGACAAGAGTGAATCACACACGAGGAATGTGTTCATTC TTTTATTGTCCGTTGTTTTAACCTGACTGAATACAAGATCAACAAGAGCACTGTACTCCTGGCAATTATTACATATGTTAGAACATGGAT TTTGCACTGTAGACAACATTTAACACCAGTCTATGGGGTACTGCATTGCTTTTTATAAAGTTCAAAATAAAGATTTATTTTCAAACAA >3928_3928_2_ALDH9A1-NME7_ALDH9A1_chr1_165651344_ENST00000354775_NME7_chr1_169206925_ENST00000472647_length(amino acids)=357AA_BP=232 MPLKSPRTDPAAPPLPRPRPSRGPSASAAELRPPLMFLRAGLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTEKA FEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYA GLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYK GVVTEYHDMVTEMYSGPCVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFKILDN -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ALDH9A1-NME7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ALDH9A1-NME7 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ALDH9A1-NME7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ALDH9A1 | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
Hgene | ALDH9A1 | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
Hgene | ALDH9A1 | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
Hgene | ALDH9A1 | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
Hgene | ALDH9A1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Hgene | ALDH9A1 | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
Tgene | C0013146 | Drug abuse | 1 | CTD_human | |
Tgene | C0013170 | Drug habituation | 1 | CTD_human | |
Tgene | C0013222 | Drug Use Disorders | 1 | CTD_human | |
Tgene | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human | |
Tgene | C0037221 | Situs Inversus | 1 | ORPHANET | |
Tgene | C0038580 | Substance Dependence | 1 | CTD_human | |
Tgene | C0038586 | Substance Use Disorders | 1 | CTD_human | |
Tgene | C0236969 | Substance-Related Disorders | 1 | CTD_human | |
Tgene | C0238198 | Gastrointestinal Stromal Tumors | 1 | CTD_human | |
Tgene | C0740858 | Substance abuse problem | 1 | CTD_human | |
Tgene | C1510472 | Drug Dependence | 1 | CTD_human | |
Tgene | C3179349 | Gastrointestinal Stromal Sarcoma | 1 | CTD_human | |
Tgene | C4316881 | Prescription Drug Abuse | 1 | CTD_human |