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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGF12-LRRC15 (FusionGDB2 ID:HG2257TG131578)

Fusion Gene Summary for FGF12-LRRC15

check button Fusion gene summary
Fusion gene informationFusion gene name: FGF12-LRRC15
Fusion gene ID: hg2257tg131578
HgeneTgene
Gene symbol

FGF12

LRRC15

Gene ID

2257

131578

Gene namefibroblast growth factor 12leucine rich repeat containing 15
SynonymsEIEE47|FGF12B|FHF1LIB
Cytomap('FGF12')('LRRC15')

3q28-q29

3q29

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor 12fibroblast growth factor 12Bfibroblast growth factor FGF-12bfibroblast growth factor homologous factor 1myocyte-activating factorleucine-rich repeat-containing protein 15hLibleucine-rich repeat protein induced by beta amyloidleucine-rich repeat protein induced by beta-amyloid homolog
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264730, ENST00000430714, 
ENST00000445105, ENST00000450716, 
ENST00000466144, ENST00000454309, 
Fusion gene scores* DoF score10 X 7 X 4=2802 X 2 X 2=8
# samples 103
** MAII scorelog2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: FGF12 [Title/Abstract] AND LRRC15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGF12(192444970)-LRRC15(194081775), # samples:2
Anticipated loss of major functional domain due to fusion event.FGF12-LRRC15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGF12-LRRC15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGF12-LRRC15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FGF12-LRRC15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FGF12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LRRC15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-51-6867-01AFGF12chr3

192444970

-LRRC15chr3

194081775

-


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Fusion Gene ORF analysis for FGF12-LRRC15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264730ENST00000347624FGF12chr3

192444970

-LRRC15chr3

194081775

-
5CDS-5UTRENST00000264730ENST00000428839FGF12chr3

192444970

-LRRC15chr3

194081775

-
5CDS-5UTRENST00000430714ENST00000347624FGF12chr3

192444970

-LRRC15chr3

194081775

-
5CDS-5UTRENST00000430714ENST00000428839FGF12chr3

192444970

-LRRC15chr3

194081775

-
5CDS-5UTRENST00000445105ENST00000347624FGF12chr3

192444970

-LRRC15chr3

194081775

-
5CDS-5UTRENST00000445105ENST00000428839FGF12chr3

192444970

-LRRC15chr3

194081775

-
5CDS-5UTRENST00000450716ENST00000347624FGF12chr3

192444970

-LRRC15chr3

194081775

-
5CDS-5UTRENST00000450716ENST00000428839FGF12chr3

192444970

-LRRC15chr3

194081775

-
5UTR-3CDSENST00000466144ENST00000439944FGF12chr3

192444970

-LRRC15chr3

194081775

-
5UTR-5UTRENST00000466144ENST00000347624FGF12chr3

192444970

-LRRC15chr3

194081775

-
5UTR-5UTRENST00000466144ENST00000428839FGF12chr3

192444970

-LRRC15chr3

194081775

-
Frame-shiftENST00000264730ENST00000439944FGF12chr3

192444970

-LRRC15chr3

194081775

-
Frame-shiftENST00000430714ENST00000439944FGF12chr3

192444970

-LRRC15chr3

194081775

-
Frame-shiftENST00000445105ENST00000439944FGF12chr3

192444970

-LRRC15chr3

194081775

-
In-frameENST00000450716ENST00000439944FGF12chr3

192444970

-LRRC15chr3

194081775

-
intron-3CDSENST00000454309ENST00000439944FGF12chr3

192444970

-LRRC15chr3

194081775

-
intron-5UTRENST00000454309ENST00000347624FGF12chr3

192444970

-LRRC15chr3

194081775

-
intron-5UTRENST00000454309ENST00000428839FGF12chr3

192444970

-LRRC15chr3

194081775

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000450716FGF12chr3192444970-ENST00000439944LRRC15chr3194081775-6004204301952640

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000450716ENST00000439944FGF12chr3192444970-LRRC15chr3194081775-0.0155541790.98444587

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Fusion Genomic Features for FGF12-LRRC15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FGF12-LRRC15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:192444970/chr3:194081775)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRC15chr3:192444970chr3:194081775ENST000003476240222_530582.0DomainNote=LRRNT
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402423_4750582.0DomainNote=LRRCT
TgeneLRRC15chr3:192444970chr3:194081775ENST000004288391322_535588.0DomainNote=LRRNT
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913423_4755588.0DomainNote=LRRCT
TgeneLRRC15chr3:192444970chr3:194081775ENST000004399440222_535588.0DomainNote=LRRNT
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402423_4755588.0DomainNote=LRRCT
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402102_1230582.0RepeatNote=LRR 3
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402126_1470582.0RepeatNote=LRR 4
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402150_1710582.0RepeatNote=LRR 5
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402174_1950582.0RepeatNote=LRR 6
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402198_2190582.0RepeatNote=LRR 7
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402222_2430582.0RepeatNote=LRR 8
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402246_2670582.0RepeatNote=LRR 9
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402270_2910582.0RepeatNote=LRR 10
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402294_3150582.0RepeatNote=LRR 11
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402318_3390582.0RepeatNote=LRR 12
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402342_3630582.0RepeatNote=LRR 13
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402366_3870582.0RepeatNote=LRR 14
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402390_4110582.0RepeatNote=LRR 15
TgeneLRRC15chr3:192444970chr3:194081775ENST000003476240254_750582.0RepeatNote=LRR 1
TgeneLRRC15chr3:192444970chr3:194081775ENST000003476240278_990582.0RepeatNote=LRR 2
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913102_1235588.0RepeatNote=LRR 3
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913126_1475588.0RepeatNote=LRR 4
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913150_1715588.0RepeatNote=LRR 5
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913174_1955588.0RepeatNote=LRR 6
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913198_2195588.0RepeatNote=LRR 7
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913222_2435588.0RepeatNote=LRR 8
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913246_2675588.0RepeatNote=LRR 9
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913270_2915588.0RepeatNote=LRR 10
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913294_3155588.0RepeatNote=LRR 11
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913318_3395588.0RepeatNote=LRR 12
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913342_3635588.0RepeatNote=LRR 13
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913366_3875588.0RepeatNote=LRR 14
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913390_4115588.0RepeatNote=LRR 15
TgeneLRRC15chr3:192444970chr3:194081775ENST000004288391354_755588.0RepeatNote=LRR 1
TgeneLRRC15chr3:192444970chr3:194081775ENST000004288391378_995588.0RepeatNote=LRR 2
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402102_1235588.0RepeatNote=LRR 3
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402126_1475588.0RepeatNote=LRR 4
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402150_1715588.0RepeatNote=LRR 5
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402174_1955588.0RepeatNote=LRR 6
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402198_2195588.0RepeatNote=LRR 7
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402222_2435588.0RepeatNote=LRR 8
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402246_2675588.0RepeatNote=LRR 9
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402270_2915588.0RepeatNote=LRR 10
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402294_3155588.0RepeatNote=LRR 11
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402318_3395588.0RepeatNote=LRR 12
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402342_3635588.0RepeatNote=LRR 13
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402366_3875588.0RepeatNote=LRR 14
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402390_4115588.0RepeatNote=LRR 15
TgeneLRRC15chr3:192444970chr3:194081775ENST000004399440254_755588.0RepeatNote=LRR 1
TgeneLRRC15chr3:192444970chr3:194081775ENST000004399440278_995588.0RepeatNote=LRR 2
TgeneLRRC15chr3:192444970chr3:194081775ENST000003476240222_5380582.0Topological domainExtracellular
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402560_5810582.0Topological domainCytoplasmic
TgeneLRRC15chr3:192444970chr3:194081775ENST000004288391322_5385588.0Topological domainExtracellular
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913560_5815588.0Topological domainCytoplasmic
TgeneLRRC15chr3:192444970chr3:194081775ENST000004399440222_5385588.0Topological domainExtracellular
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402560_5815588.0Topological domainCytoplasmic
TgeneLRRC15chr3:192444970chr3:194081775ENST0000034762402539_5590582.0TransmembraneHelical
TgeneLRRC15chr3:192444970chr3:194081775ENST0000042883913539_5595588.0TransmembraneHelical
TgeneLRRC15chr3:192444970chr3:194081775ENST0000043994402539_5595588.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGF12chr3:192444970chr3:194081775ENST00000264730-1511_384182.0MotifBipartite nuclear localization signal
HgeneFGF12chr3:192444970chr3:194081775ENST00000445105-2611_384182.0MotifBipartite nuclear localization signal
HgeneFGF12chr3:192444970chr3:194081775ENST00000450716-2611_384182.0MotifBipartite nuclear localization signal
HgeneFGF12chr3:192444970chr3:194081775ENST00000454309-1511_380244.0MotifBipartite nuclear localization signal


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Fusion Gene Sequence for FGF12-LRRC15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30201_30201_1_FGF12-LRRC15_FGF12_chr3_192444970_ENST00000450716_LRRC15_chr3_194081775_ENST00000439944_length(transcript)=6004nt_BP=204nt
TTAAAGCAGGAGCCTTGAGAGCCTGATAAGCTGTTGACACAAGTGCTTTTGAGAATAGCAGGAAGCCTGAGGGGAAGGAAGGAAGTACGG
GCGAAATCATCAGATTGGCTTCCCAGATTTGGGAATCTGAAGCGGGCCCACATCTTCCGGCCAACTTCCATTGAACTTCCCAGCACTCGA
AAGGGACCGAAATGGAGAGCAAAGGCTATGCCACTGAAGCATTATCTCCTTTTGCTGGTGGGCTGCCAAGCCTGGGGTGCAGGGTTGGCC
TACCATGGCTGCCCTAGCGAGTGTACCTGCTCCAGGGCCTCCCAGGTGGAGTGCACCGGGGCACGCATTGTGGCAGTGCCCACCCCTCTG
CCCTGGAACGCCATGAGCCTGCAGATCCTCAACACGCACATCACTGAACTCAATGAGTCCCCGTTCCTCAATATCTCAGCCCTCATCGCC
CTGAGGATTGAGAAGAATGAGCTGTCGCGCATCACGCCTGGGGCCTTCCGAAACCTGGGCTCGCTGCGCTATCTCAGCCTCGCCAACAAC
AAGCTGCAGGTTCTGCCCATCGGCCTCTTCCAGGGCCTGGACAGCCTCGAGTCTCTCCTTCTGTCCAGTAACCAGCTGTTGCAGATCCAG
CCGGCCCACTTCTCCCAGTGCAGCAACCTCAAGGAGCTGCAGTTGCACGGCAACCACCTGGAATACATCCCTGACGGAGCCTTCGACCAC
CTGGTAGGACTCACGAAGCTCAATCTGGGCAAGAATAGCCTCACCCACATCTCACCCAGGGTCTTCCAGCACCTGGGCAACCTCCAGGTC
CTCCGGCTGTATGAGAACAGGCTCACGGATATCCCCATGGGCACTTTTGATGGGCTTGTTAACCTGCAGGAACTGGCTCTGCAGCAGAAC
CAGATTGGACTGCTCTCCCCTGGTCTCTTCCACAACAACCACAACCTCCAGAGACTCTACCTGTCCAACAACCACATCTCCCAGCTGCCA
CCCAGCGTCTTCATGCAGCTGCCCCAGCTCAACCGTCTTACTCTCTTTGGGAATTCCCTGAAGGAGCTCTCTCCGGGGATCTTCGGGCCC
ATGCCCAACCTGCGGGAGCTTTGGCTCTATGACAACCACATCTCTTCTCTACCCGACAATGTCTTCAGCAACCTCCGCCAGTTGCAGGTC
CTGATTCTTAGCCGCAATCAGATCAGCTTCATCTCCCCGGGTGCCTTCAACGGGCTAACGGAGCTTCGGGAGCTGTCCCTCCACACCAAC
GCACTGCAGGACCTGGACGGGAACGTCTTCCGCATGTTGGCCAACCTGCAGAACATCTCCCTGCAGAACAACCGCCTCAGACAGCTCCCA
GGGAATATCTTCGCCAACGTCAATGGCCTCATGGCCATCCAGCTGCAGAACAACCAGCTGGAGAACTTGCCCCTCGGCATCTTCGATCAC
CTGGGGAAACTGTGTGAGCTGCGGCTGTATGACAATCCCTGGAGGTGTGACTCAGACATCCTTCCGCTCCGCAACTGGCTCCTGCTCAAC
CAGCCTAGGTTAGGGACGGACACTGTACCTGTGTGTTTCAGCCCAGCCAATGTCCGAGGCCAGTCCCTCATTATCATCAATGTCAACGTT
GCTGTTCCAAGCGTCCATGTCCCCGAGGTGCCTAGTTACCCAGAAACACCATGGTACCCAGACACACCCAGTTACCCTGACACCACATCC
GTCTCTTCTACCACTGAGCTAACCAGCCCTGTGGAAGACTACACTGATCTGACTACCATTCAGGTCACTGATGACCGCAGCGTTTGGGGC
ATGACCCAGGCCCAGAGCGGGCTGGCCATTGCCGCCATTGTAATTGGCATTGTCGCCCTGGCCTGCTCCCTGGCTGCCTGCGTCGGCTGT
TGCTGCTGCAAGAAGAGGAGCCAAGCTGTCCTGATGCAGATGAAGGCACCCAATGAGTGTTAAAGAGGCAGGCTGGAGCAGGGCTGGGGA
ATGATGGGACTGGAGGACCTGGGAATTTCATCTTTCTGCCTCCACCCCTGGGTCCATGGAGCTTTCCCGTGATTGCTCTTTCTGGCCCCA
GAGAAAGGTGAGCCTACCTCTTCCTGACTTGCCTGATTCTCCCGTAGAGAAGCAGGTCGTGCCGGACCTTCCTACAATCAGGAAGATAGA
TCCAACTGGCCATGGCAAAAGCCCTGGGGATTTCCGATTCATACCCCTGGGCTTCCTTCGAGAGGGCTCTTCCTCCAAATCCTCCCCACC
TGTCCTCCAAGAACAGCCTTCCCTGCGCCCAGGCCCCCTCCGGGCCTCTGTAGACTCAGTTAGTCCACAGCCTGCTCACTTCGTGGGAAT
AGTTCTCCGCTGAGATAGCCCCTCTCGCCTAAGTATTATGTAAGTTGATTTCCCTTCTTTTGTTTCTCTTGTTTGTGCTACGGCTTGACC
CAGCATGTCCCCTCAAATGAAAGTTCTCCCCTTGATTTTCTGCTCCTGAAGGCAGGGTGAGTTCTCTCCTCAAAGAAGACTTCAAACCAT
TTAACTGGTTTCTTAAGAGCCGTCAATCAGCCTGGTTTTGGGGATGCTATGAAAGAGAGAAGGAAAATCATGCCGCTCAGTTCCTGGAGA
CAGAAGAGCCGTCATCAGTGTCTCACTTGTGATTTTTATCTGGAAAAGGAAGAAACACCCCAGCACAGCAAGCTCAGCCTTTTAGAGAAG
GATATTTCCAAACTGCAAACTTTGCTTTGAAAAGTTTAGCCCTTTAAGGAATGAAATCATGTAGAATTTTGGACTTCTAAAAACATTAAA
ATCAGCTTATTAATACGGGATAGAGAAAGAAATCTGGTGCCTGGGGGTCCCTGTGTTCACCCCTAGAGTTTGTTTTAAAATTTTTAATTG
AAGCATGTGAAGTGTACGTGCAGAAAAGTGGGAACATGATAGTGTATGGCTTGGTGGATTTTCACAAACTGAACATACCTGTGTAATCAG
CATCTAGACCCAGACCCAGAGCATCACAAATATCCCCCATCCTGGGCTTTTCCCAGAGGAGATGGGGGCTTCTGAAGATGGACTTACCTG
GGACCTGCCCCCCATGAGCCAGGACGGTCCCCCCACAGTCAGCCTGTGCAAAGGCCCCGTGGCCAGGGGTGGAGGAGAATATGTGGGTGT
GGACAGGATGGGAGACTGTGGCCTGAACAGGAGATTTTATTATATCTGGAGACCCTGAGAGACCCTGAGACCTGGGGCACCATGGCTGGC
CAGGTCAGAAGCATCCTGACTGCAGAGGTCCGTGCAGCCACACCCTCTTCCCTGCCAGCAAGCTGTCTGCGGCTCATCGGAGGCCCCTCC
GCCTGGAGCCTTCTATGGACGTGATATGCCTGTATCTGTTTTTAATTTTCATTCTTCACTTAGGGGAAGTGAAATCGCTCAGAGATGAGA
TCCTTTAATTGAAAACGAAGTGTAACGGAATCTAGTGTCTTTCTAATGTGGTAAAATTCTCCATCAACATCACAGTCAGCTGGCAGCTGA
ACTTCAGAATCTCACTTACAGCAGGCGACACGGGGGTACACCGATGGGTCACACTGGGTCTGGGGGCTCCCTGGAGCTCCTCCTGCGTGT
GGTCTGGTTAGGAGTTGAGTTGTTTGCTCCAGGGTTATTCTCCTCCTCGAGTCACAGTCACACGAATACCTGCCTTCTCTGGCTTTCCTG
CTATACACATATTCACATGGCGCTCAAGAAGTTAGGCTCATGGCAACGTGTGTCTTTCTCTGGACAACTGGCCCAGTTTACAGTGAAATG
GAGAATTTCAGGTCTCCACGTCTGCCCAGGAAAGAACTTCAGCTGACTCCACGGGGATCTGGAAATCCACGACCAATCCCGATCGGCTCT
TATTAGCTCCCCGCTCCACAAGACACCTGTGCTTTGGAAATCCACCACCAATCCCGATCGGCTCTTATTAGCTCCCCGCTCCACAAGACA
CCTGTGATCTGGAAATCTACCACCAATCCCGATCGGCTCTTATTAGCTCCCCGCTCCACAAGACACCTGTGACATCCTCCAGGGCCACAG
GAGCACGTGCTGACCAGTTTTCCCTTCCAGTTCCTGCACAAAAAGTGTCCAGAGGGCTGTTTGCAAACACTAGTGCACTTTGTAGCTTTT
CACCCTCTGTCCCAGGGAATCTAGGAGAGATGAGGCCCGTCAGAGTCAAGAGATGTCATCCCCCCAGGGTCTCCAAGGCATTTCCACACT
ATTGGTGGCACCTGGAGGACATGCACCAAGGCTTGCCAGAGCCAACAGGAAGTGAGCCCAGAGCATGGCACATGAGCATCACCCGCTGAT
GGTGGCCTGCTGTGCCTGGTGCCAACAGGGGCATCCCGGCCCGTACCCCTCCAGACAGGAAGCATGGGTTTGCCCACAGACCTGTCGGGT
GCTCCTGTGAGTGGCCTCCAGATGTCTTTGTGCATAGGCACAAGTGGGCCAGGGCTGGAGGGAGGTGGGAAACCTCATCATCCGGTGGGC
CCTGCCAATCTTAACCCAGAACCCTTAGGTATTCCTGGCAGTAGCCATGACATTGGAGCACCTTCCTCTCCAGCCAGAGGCTGACCTGAG
GGCCACTGTCCTCAGATGACACCACCCAGGAGCACCCTAGGTGAGGGGTGAGGGCCCCCTTATGTGAACCTCTTGCCTCTTCCTTTCTCC
CATCAGAGTGGTTGGATGGAGCCATTGGCCTCCTTTTCTTCAGCGGGCCCTTCAACCTCTCTGCACCATGTTGTCTGGCTGAGGAGCTAC
TAGAAAAGCTGAGTGGAGTCTCCTTTCCAACAGGATGATGCATTTGCTCAATTCTCAGGGCTGGAATGAGCCGGCTGGTCCCCCAGAAAG
CTGGAGTGGGGTACAGAGTTCAGTTTTCCTCTCTGTTTACAGCTCCTTGACAGTCCCACGCCCATCTGGAGTGGGAGCTGGGAGTCAGTG
TTGGAGAAGAAACAACAAAAGCCAATTAGAACCACTATTTTTAAAAAGTGCTTACTGTGCACAGATACTCTTCAAGCACTGGACGTGGAT
TCTCTCTCTAGCCCTCAGCACCCCTGCGGTAGGAGTGCCGCCTCTACCCACTTGTGATGGGGTACAGAGGCACTTGCTCTTCTGCATGGT
GTTCAATAGGCTGGGAGTTTTATTTATCTCTTCAAACTTTGTACAAGAGCTCATGGCTTGTCTTGGGCTTTCGTCATTAAACCAAAGGAA
ATGGAAGCCATTCCCCTGTTGCTCTCCTTAGTCTTGGTCATCAGAACCTCACTTGGTACCATATAGATCAAAAGCTTTGTAACCACAGGA
AAAAATAAACTCTTCCATCCCTTAAAGAATAGAATAGTTTGTCCCTCTCATGGGAATTGGGCTGTATGTATATTGTTCTTCCTCCTTAGA
ATTTAGAGATACAAGAGTTCTACTTAGAACTTTTCATGGACACAATTTCCACAACCTTTCAGATGCTGATGTAGAGCTATTGGGAAAGAA
CTTCCAAACTCAGGAAGTTTGCAGAGAGCAGACAGCTAGAGATAACTCGGGACCCAGAGTTGGTCGACAGATGTTAGATGTATCCTAGCT
TTTAGCTATAAACCACTCAAAGATTCAGCCCCCAGATCCCACAGTCAGAACTGAATCTGCGTTGTTGGGAAGCCAGCAGTGGCCTTGGGA
AGGAAGCCATGGCTGTGGTTCAGAGAGGGTGGGCTGGCAAGCCACTTCCGGGGAAAACTCCTTCCGCCCCAGGTTTCTTCTTCTCTTAAG
GAGAGATTGTTCTCACCAACCCGCTGCCTTCATGCTGCCTTCAAAGCTAGATCATGTTTGCCTTGCTTAGAGAATTACTGCAAATCAGCC
CCAGTGCTTGGCGATGCATTTACAGATTTCTAGGCCCTCAGGGTTTTGTAGAGTGTGAGCCCTGGTGGGCAGGGTTGGGGGGTCTGTCTT
CTGCTGGATGCTGCTTGTAATCCATTTGGTGTACAGAATCAACAATAAATAATATACATGTATA

>30201_30201_1_FGF12-LRRC15_FGF12_chr3_192444970_ENST00000450716_LRRC15_chr3_194081775_ENST00000439944_length(amino acids)=640AA_BP=56
MLTQVLLRIAGSLRGRKEVRAKSSDWLPRFGNLKRAHIFRPTSIELPSTRKGPKWRAKAMPLKHYLLLLVGCQAWGAGLAYHGCPSECTC
SRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLF
QGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTD
IPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLY
DNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGL
MAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEV
PSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLAIAAIVIGIVALACSLAACVGCCCCKKRSQAV
LMQMKAPNEC

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Fusion Gene PPI Analysis for FGF12-LRRC15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGF12-LRRC15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGF12-LRRC15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGF12C4310685EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 473CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGF12C0019209Hepatomegaly1CTD_human
HgeneFGF12C0543888Epileptic encephalopathy1GENOMICS_ENGLAND