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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGFR3-AES (FusionGDB2 ID:HG2261TG166)

Fusion Gene Summary for FGFR3-AES

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR3-AES
Fusion gene ID: hg2261tg166
HgeneTgene
Gene symbol

FGFR3

AES

Gene ID

2261

166

Gene namefibroblast growth factor receptor 3TLE family member 5, transcriptional modulator
SynonymsACH|CD333|CEK2|HSFGFR3EX|JTK4AES|AES-1|AES-2|ESP1|GRG|GRG5|Grg-5
Cytomap('FGFR3')('AES')

4p16.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 3FGFR-3fibroblast growth factor receptor 3 variant 4fibroblast growth factor receptor 3-Shydroxyaryl-protein kinasetyrosine kinase JTK4TLE family member 5amino-terminal enhancer of splitgp130-associated protein GAMgroucho-related protein 5
Modification date2020031320200327
UniProtAcc

P22607

.
Ensembl transtripts involved in fusion geneENST00000260795, ENST00000340107, 
ENST00000352904, ENST00000412135, 
ENST00000440486, ENST00000481110, 
ENST00000474521, 
Fusion gene scores* DoF score10 X 22 X 14=308010 X 12 X 6=720
# samples 3313
** MAII scorelog2(33/3080*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGFR3 [Title/Abstract] AND AES [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGFR3(1808661)-AES(3061255), # samples:5
Anticipated loss of major functional domain due to fusion event.FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR3

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

HgeneFGFR3

GO:0018108

peptidyl-tyrosine phosphorylation

11294897

HgeneFGFR3

GO:0046777

protein autophosphorylation

11294897

TgeneAES

GO:0032091

negative regulation of protein binding

15489227

TgeneAES

GO:0045892

negative regulation of transcription, DNA-templated

19460168

TgeneAES

GO:0070555

response to interleukin-1

15489227

TgeneAES

GO:0090090

negative regulation of canonical Wnt signaling pathway

19460168


check buttonFusion gene breakpoints across FGFR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across AES (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-A7NM-01AFGFR3chr4

1808660

+AESchr19

3061254

-
ChimerDB4PRADTCGA-EJ-A7NM-01AFGFR3chr4

1808661

-AESchr19

3061255

-
ChimerDB4PRADTCGA-EJ-A7NM-01AFGFR3chr4

1808661

+AESchr19

3061255

-
ChimerDB4PRADTCGA-EJ-A7NMFGFR3chr4

1808661

+AESchr19

3061255

-


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Fusion Gene ORF analysis for FGFR3-AES

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000260795ENST00000586839FGFR3chr4

1808660

+AESchr19

3061254

-
5CDS-5UTRENST00000260795ENST00000586839FGFR3chr4

1808661

+AESchr19

3061255

-
5CDS-5UTRENST00000260795ENST00000592330FGFR3chr4

1808660

+AESchr19

3061254

-
5CDS-5UTRENST00000260795ENST00000592330FGFR3chr4

1808661

+AESchr19

3061255

-
5CDS-5UTRENST00000340107ENST00000586839FGFR3chr4

1808660

+AESchr19

3061254

-
5CDS-5UTRENST00000340107ENST00000586839FGFR3chr4

1808661

+AESchr19

3061255

-
5CDS-5UTRENST00000340107ENST00000592330FGFR3chr4

1808660

+AESchr19

3061254

-
5CDS-5UTRENST00000340107ENST00000592330FGFR3chr4

1808661

+AESchr19

3061255

-
5CDS-5UTRENST00000352904ENST00000586839FGFR3chr4

1808660

+AESchr19

3061254

-
5CDS-5UTRENST00000352904ENST00000586839FGFR3chr4

1808661

+AESchr19

3061255

-
5CDS-5UTRENST00000352904ENST00000592330FGFR3chr4

1808660

+AESchr19

3061254

-
5CDS-5UTRENST00000352904ENST00000592330FGFR3chr4

1808661

+AESchr19

3061255

-
5CDS-5UTRENST00000412135ENST00000586839FGFR3chr4

1808660

+AESchr19

3061254

-
5CDS-5UTRENST00000412135ENST00000586839FGFR3chr4

1808661

+AESchr19

3061255

-
5CDS-5UTRENST00000412135ENST00000592330FGFR3chr4

1808660

+AESchr19

3061254

-
5CDS-5UTRENST00000412135ENST00000592330FGFR3chr4

1808661

+AESchr19

3061255

-
5CDS-5UTRENST00000440486ENST00000586839FGFR3chr4

1808660

+AESchr19

3061254

-
5CDS-5UTRENST00000440486ENST00000586839FGFR3chr4

1808661

+AESchr19

3061255

-
5CDS-5UTRENST00000440486ENST00000592330FGFR3chr4

1808660

+AESchr19

3061254

-
5CDS-5UTRENST00000440486ENST00000592330FGFR3chr4

1808661

+AESchr19

3061255

-
5CDS-5UTRENST00000481110ENST00000586839FGFR3chr4

1808660

+AESchr19

3061254

-
5CDS-5UTRENST00000481110ENST00000586839FGFR3chr4

1808661

+AESchr19

3061255

-
5CDS-5UTRENST00000481110ENST00000592330FGFR3chr4

1808660

+AESchr19

3061254

-
5CDS-5UTRENST00000481110ENST00000592330FGFR3chr4

1808661

+AESchr19

3061255

-
Frame-shiftENST00000481110ENST00000221561FGFR3chr4

1808660

+AESchr19

3061254

-
Frame-shiftENST00000481110ENST00000221561FGFR3chr4

1808661

+AESchr19

3061255

-
Frame-shiftENST00000481110ENST00000327141FGFR3chr4

1808660

+AESchr19

3061254

-
Frame-shiftENST00000481110ENST00000327141FGFR3chr4

1808661

+AESchr19

3061255

-
In-frameENST00000260795ENST00000221561FGFR3chr4

1808660

+AESchr19

3061254

-
In-frameENST00000260795ENST00000221561FGFR3chr4

1808661

+AESchr19

3061255

-
In-frameENST00000260795ENST00000327141FGFR3chr4

1808660

+AESchr19

3061254

-
In-frameENST00000260795ENST00000327141FGFR3chr4

1808661

+AESchr19

3061255

-
In-frameENST00000340107ENST00000221561FGFR3chr4

1808660

+AESchr19

3061254

-
In-frameENST00000340107ENST00000221561FGFR3chr4

1808661

+AESchr19

3061255

-
In-frameENST00000340107ENST00000327141FGFR3chr4

1808660

+AESchr19

3061254

-
In-frameENST00000340107ENST00000327141FGFR3chr4

1808661

+AESchr19

3061255

-
In-frameENST00000352904ENST00000221561FGFR3chr4

1808660

+AESchr19

3061254

-
In-frameENST00000352904ENST00000221561FGFR3chr4

1808661

+AESchr19

3061255

-
In-frameENST00000352904ENST00000327141FGFR3chr4

1808660

+AESchr19

3061254

-
In-frameENST00000352904ENST00000327141FGFR3chr4

1808661

+AESchr19

3061255

-
In-frameENST00000412135ENST00000221561FGFR3chr4

1808660

+AESchr19

3061254

-
In-frameENST00000412135ENST00000221561FGFR3chr4

1808661

+AESchr19

3061255

-
In-frameENST00000412135ENST00000327141FGFR3chr4

1808660

+AESchr19

3061254

-
In-frameENST00000412135ENST00000327141FGFR3chr4

1808661

+AESchr19

3061255

-
In-frameENST00000440486ENST00000221561FGFR3chr4

1808660

+AESchr19

3061254

-
In-frameENST00000440486ENST00000221561FGFR3chr4

1808661

+AESchr19

3061255

-
In-frameENST00000440486ENST00000327141FGFR3chr4

1808660

+AESchr19

3061254

-
In-frameENST00000440486ENST00000327141FGFR3chr4

1808661

+AESchr19

3061255

-
intron-3CDSENST00000474521ENST00000221561FGFR3chr4

1808660

+AESchr19

3061254

-
intron-3CDSENST00000474521ENST00000221561FGFR3chr4

1808661

+AESchr19

3061255

-
intron-3CDSENST00000474521ENST00000327141FGFR3chr4

1808660

+AESchr19

3061254

-
intron-3CDSENST00000474521ENST00000327141FGFR3chr4

1808661

+AESchr19

3061255

-
intron-5UTRENST00000474521ENST00000586839FGFR3chr4

1808660

+AESchr19

3061254

-
intron-5UTRENST00000474521ENST00000586839FGFR3chr4

1808661

+AESchr19

3061255

-
intron-5UTRENST00000474521ENST00000592330FGFR3chr4

1808660

+AESchr19

3061254

-
intron-5UTRENST00000474521ENST00000592330FGFR3chr4

1808661

+AESchr19

3061255

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000440486FGFR3chr41808661+ENST00000221561AESchr193061255-400625302233096957
ENST00000440486FGFR3chr41808661+ENST00000327141AESchr193061255-375425302233096957
ENST00000412135FGFR3chr41808661+ENST00000221561AESchr193061255-367021942232760845
ENST00000412135FGFR3chr41808661+ENST00000327141AESchr193061255-341821942232760845
ENST00000340107FGFR3chr41808661+ENST00000221561AESchr193061255-401225362233102959
ENST00000340107FGFR3chr41808661+ENST00000327141AESchr193061255-376025362233102959
ENST00000260795FGFR3chr41808661+ENST00000221561AESchr193061255-38522376692942957
ENST00000260795FGFR3chr41808661+ENST00000327141AESchr193061255-36002376692942957
ENST00000352904FGFR3chr41808661+ENST00000221561AESchr193061255-3453197762543845
ENST00000352904FGFR3chr41808661+ENST00000327141AESchr193061255-3201197762543845
ENST00000440486FGFR3chr41808660+ENST00000221561AESchr193061254-400625302233096957
ENST00000440486FGFR3chr41808660+ENST00000327141AESchr193061254-375425302233096957
ENST00000412135FGFR3chr41808660+ENST00000221561AESchr193061254-367021942232760845
ENST00000412135FGFR3chr41808660+ENST00000327141AESchr193061254-341821942232760845
ENST00000340107FGFR3chr41808660+ENST00000221561AESchr193061254-401225362233102959
ENST00000340107FGFR3chr41808660+ENST00000327141AESchr193061254-376025362233102959
ENST00000260795FGFR3chr41808660+ENST00000221561AESchr193061254-38522376692942957
ENST00000260795FGFR3chr41808660+ENST00000327141AESchr193061254-36002376692942957
ENST00000352904FGFR3chr41808660+ENST00000221561AESchr193061254-3453197762543845
ENST00000352904FGFR3chr41808660+ENST00000327141AESchr193061254-3201197762543845

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000440486ENST00000221561FGFR3chr41808661+AESchr193061255-0.0011429210.99885714
ENST00000440486ENST00000327141FGFR3chr41808661+AESchr193061255-0.0020051870.9979948
ENST00000412135ENST00000221561FGFR3chr41808661+AESchr193061255-0.0025371650.99746287
ENST00000412135ENST00000327141FGFR3chr41808661+AESchr193061255-0.0045722470.9954277
ENST00000340107ENST00000221561FGFR3chr41808661+AESchr193061255-0.0012532850.99874663
ENST00000340107ENST00000327141FGFR3chr41808661+AESchr193061255-0.0021560610.997844
ENST00000260795ENST00000221561FGFR3chr41808661+AESchr193061255-0.0011089410.99889106
ENST00000260795ENST00000327141FGFR3chr41808661+AESchr193061255-0.0019780680.99802196
ENST00000352904ENST00000221561FGFR3chr41808661+AESchr193061255-0.002323910.9976761
ENST00000352904ENST00000327141FGFR3chr41808661+AESchr193061255-0.0043884160.9956116
ENST00000440486ENST00000221561FGFR3chr41808660+AESchr193061254-0.0011429210.99885714
ENST00000440486ENST00000327141FGFR3chr41808660+AESchr193061254-0.0020051870.9979948
ENST00000412135ENST00000221561FGFR3chr41808660+AESchr193061254-0.0025371650.99746287
ENST00000412135ENST00000327141FGFR3chr41808660+AESchr193061254-0.0045722470.9954277
ENST00000340107ENST00000221561FGFR3chr41808660+AESchr193061254-0.0012532850.99874663
ENST00000340107ENST00000327141FGFR3chr41808660+AESchr193061254-0.0021560610.997844
ENST00000260795ENST00000221561FGFR3chr41808660+AESchr193061254-0.0011089410.99889106
ENST00000260795ENST00000327141FGFR3chr41808660+AESchr193061254-0.0019780680.99802196
ENST00000352904ENST00000221561FGFR3chr41808660+AESchr193061254-0.002323910.9976761
ENST00000352904ENST00000327141FGFR3chr41808660+AESchr193061254-0.0043884160.9956116

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Fusion Genomic Features for FGFR3-AES


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FGFR3-AES


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:1808661/chr19:3061255)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR3

P22607

.
FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. {ECO:0000269|PubMed:10611230, ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:11703096, ECO:0000269|PubMed:14534538, ECO:0000269|PubMed:16410555, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17145761, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:19286672, ECO:0000269|PubMed:8663044}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+1617151_244758807.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+161724_126758807.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+1617253_355758807.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+1617472_761758807.0DomainProtein kinase
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+1718151_244760809.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+171824_126760809.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+1718253_355760809.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+1718472_761760809.0DomainProtein kinase
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+1415151_244646695.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+141524_126646695.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+1415253_355646695.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+1516151_244646695.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+151624_126646695.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+1516253_355646695.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+1718151_244758807.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+171824_126758807.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+1718253_355758807.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+1718472_761758807.0DomainProtein kinase
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+1617151_244758807.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+161724_126758807.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+1617253_355758807.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+1617472_761758807.0DomainProtein kinase
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+1718151_244760809.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+171824_126760809.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+1718253_355760809.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+1718472_761760809.0DomainProtein kinase
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+1415151_244646695.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+141524_126646695.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+1415253_355646695.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+1516151_244646695.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+151624_126646695.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+1516253_355646695.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+1718151_244758807.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+171824_126758807.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+1718253_355758807.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+1718472_761758807.0DomainProtein kinase
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+1617478_486758807.0Nucleotide bindingATP
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+1718478_486760809.0Nucleotide bindingATP
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+1415478_486646695.0Nucleotide bindingATP
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+1516478_486646695.0Nucleotide bindingATP
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+1718478_486758807.0Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+1617478_486758807.0Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+1718478_486760809.0Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+1415478_486646695.0Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+1516478_486646695.0Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+1718478_486758807.0Nucleotide bindingATP
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+161723_375758807.0Topological domainExtracellular
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+171823_375760809.0Topological domainExtracellular
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+141523_375646695.0Topological domainExtracellular
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+151623_375646695.0Topological domainExtracellular
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+171823_375758807.0Topological domainExtracellular
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+161723_375758807.0Topological domainExtracellular
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+171823_375760809.0Topological domainExtracellular
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+141523_375646695.0Topological domainExtracellular
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+151623_375646695.0Topological domainExtracellular
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+171823_375758807.0Topological domainExtracellular
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+1617376_396758807.0TransmembraneHelical
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+1718376_396760809.0TransmembraneHelical
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+1415376_396646695.0TransmembraneHelical
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+1516376_396646695.0TransmembraneHelical
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+1718376_396758807.0TransmembraneHelical
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+1617376_396758807.0TransmembraneHelical
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+1718376_396760809.0TransmembraneHelical
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+1415376_396646695.0TransmembraneHelical
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+1516376_396646695.0TransmembraneHelical
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+1718376_396758807.0TransmembraneHelical
TgeneAESchr4:1808660chr19:3061254ENST0000022156107132_16576265.0Compositional biasNote=Gly/Pro-rich (GP domain)
TgeneAESchr4:1808660chr19:3061254ENST0000032714107132_1659198.0Compositional biasNote=Gly/Pro-rich (GP domain)
TgeneAESchr4:1808661chr19:3061255ENST0000022156107132_16576265.0Compositional biasNote=Gly/Pro-rich (GP domain)
TgeneAESchr4:1808661chr19:3061255ENST0000032714107132_1659198.0Compositional biasNote=Gly/Pro-rich (GP domain)
TgeneAESchr4:1808660chr19:3061254ENST0000022156107166_19776265.0RegionNote=CCN domain
TgeneAESchr4:1808660chr19:3061254ENST0000032714107166_1979198.0RegionNote=CCN domain
TgeneAESchr4:1808661chr19:3061255ENST0000022156107166_19776265.0RegionNote=CCN domain
TgeneAESchr4:1808661chr19:3061255ENST0000032714107166_1979198.0RegionNote=CCN domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+1415472_761646695.0DomainProtein kinase
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+1516472_761646695.0DomainProtein kinase
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+1415472_761646695.0DomainProtein kinase
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+1516472_761646695.0DomainProtein kinase
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+1617397_806758807.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+1718397_806760809.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+1415397_806646695.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+1516397_806646695.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+1718397_806758807.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+1617397_806758807.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+1718397_806760809.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+1415397_806646695.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+1516397_806646695.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+1718397_806758807.0Topological domainCytoplasmic
TgeneAESchr4:1808660chr19:3061254ENST00000221561071_13176265.0Compositional biasNote=Gln-rich (Q domain)
TgeneAESchr4:1808660chr19:3061254ENST00000327141071_1319198.0Compositional biasNote=Gln-rich (Q domain)
TgeneAESchr4:1808661chr19:3061255ENST00000221561071_13176265.0Compositional biasNote=Gln-rich (Q domain)
TgeneAESchr4:1808661chr19:3061255ENST00000327141071_1319198.0Compositional biasNote=Gln-rich (Q domain)


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Fusion Gene Sequence for FGFR3-AES


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30299_30299_1_FGFR3-AES_FGFR3_chr4_1808660_ENST00000260795_AES_chr19_3061254_ENST00000221561_length(transcript)=3852nt_BP=2376nt
TCTCCCGAGCGGCGCCCGCCTCCCGCCGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCC
CCCGCCCCCGCCATGGGCGCCCCTGCCTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGG
ACGGAGCAGCGCGTCGTGGGGCGAGCGGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCT
GTGGAGCTGAGCTGTCCCCCGCCCGGGGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGT
GTCCTGGTGGGGCCCCAGCGGCTGCAGGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGC
GTACTGTGCCACTTCAGTGTGCGGGTGACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTG
GACACAGGGGCCCCTTACTGGACACGGCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGC
CCAGCCGCTGGCAACCCCACTCCCTCCATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTG
CGGCATCAGCAGTGGAGCCTGGTCATGGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGC
ATCCGGCAGACGTACACGCTGGACGTGCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTG
CTGGGCAGCGACGTGGAGTTCCACTGCAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGC
AAGGTGGGCCCGGACGGCACACCCTACGTTACCGTGCTCAAGACGGCGGGCGCTAACACCACCGACAAGGAGCTAGAGGTTCTCTCCTTG
CACAACGTCACCTTTGAGGACGCCGGGGAGTACACCTGCCTGGCGGGCAATTCTATTGGGTTTTCTCATCACTCTGCGTGGCTGGTGGTG
CTGCCAGCCGAGGAGGAGCTGGTGGAGGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTC
ATCCTGGTGGTGGCGGCTGTGACGCTCTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGC
TTCCCGCTCAAGCGACAGGTGTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGG
GAGGGCCCCACGCTGGCCAATGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAG
CCCCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCC
GTGAAGATGCTGAAAGACGATGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAA
AACATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTT
CTGCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCC
TGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACC
GAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTG
CCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAG
ATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCC
GCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAG
GACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGAC
CGCATCAAAGACGAATTTCAGCTACTGCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATG
CAGCGTCACTATGTGATGTACTACGAGATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGG
ATTTGTGCCCAGGTCCTGCCCTACCTCTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCC
GAGCTGAACTCTATCATCCGACAGCAGCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTG
GGGCTGCAGCCGCCTTCGCTGCCGGCGGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAG
GAAGACAAGAACGGGCACGATGGTGACACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGA
GGGGGGACAGAGGGGAGACAGAGGCACGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGT
ATTTATGGTGGCCGCCGGCGGGGGCCCCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTC
CCCTGCAGCCTGGTTAGGTGGATACCTGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAG
CAAGACCTCGCGAAGCGCAGCAGCCCCGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCC
TGGTACTGCATGCACGCAATGCTAGCTGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCAC
CTCCACCTGCCCCACTCACCACCTCTGCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACG
AGGGACGAGCTTAGCTGAGCTGGGAGGAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACT
AAAGTTGTCTTGGTTTTTATTTTATTATTATTTTTTTCTTTTTCCAGTATACTAGCTTGTCTTTTAAGAAAGGGGATATTAAAAAAAAAA
AAAGACAAAAGTGTTTTTAAAAAAAAGCAACACCCACACCTGTGTCTGTATATAGTCAGCTTATCTCGTGTTCAATCGTCTGATCTCTAC
AGAGAGAAGTGGAAAATGCTGTATCAAGGGTGGGCTTAGCTGTGCCTTTCCAATAAAGATGTGAGAAGCTTC

>30299_30299_1_FGFR3-AES_FGFR3_chr4_1808660_ENST00000260795_AES_chr19_3061254_ENST00000221561_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL
PLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_2_FGFR3-AES_FGFR3_chr4_1808660_ENST00000260795_AES_chr19_3061254_ENST00000327141_length(transcript)=3600nt_BP=2376nt
TCTCCCGAGCGGCGCCCGCCTCCCGCCGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCC
CCCGCCCCCGCCATGGGCGCCCCTGCCTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGG
ACGGAGCAGCGCGTCGTGGGGCGAGCGGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCT
GTGGAGCTGAGCTGTCCCCCGCCCGGGGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGT
GTCCTGGTGGGGCCCCAGCGGCTGCAGGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGC
GTACTGTGCCACTTCAGTGTGCGGGTGACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTG
GACACAGGGGCCCCTTACTGGACACGGCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGC
CCAGCCGCTGGCAACCCCACTCCCTCCATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTG
CGGCATCAGCAGTGGAGCCTGGTCATGGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGC
ATCCGGCAGACGTACACGCTGGACGTGCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTG
CTGGGCAGCGACGTGGAGTTCCACTGCAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGC
AAGGTGGGCCCGGACGGCACACCCTACGTTACCGTGCTCAAGACGGCGGGCGCTAACACCACCGACAAGGAGCTAGAGGTTCTCTCCTTG
CACAACGTCACCTTTGAGGACGCCGGGGAGTACACCTGCCTGGCGGGCAATTCTATTGGGTTTTCTCATCACTCTGCGTGGCTGGTGGTG
CTGCCAGCCGAGGAGGAGCTGGTGGAGGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTC
ATCCTGGTGGTGGCGGCTGTGACGCTCTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGC
TTCCCGCTCAAGCGACAGGTGTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGG
GAGGGCCCCACGCTGGCCAATGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAG
CCCCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCC
GTGAAGATGCTGAAAGACGATGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAA
AACATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTT
CTGCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCC
TGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACC
GAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTG
CCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAG
ATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCC
GCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAG
GACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGAC
CGCATCAAAGACGAATTTCAGCTACTGCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATG
CAGCGTCACTATGTGATGTACTACGAGATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGG
ATTTGTGCCCAGGTCCTGCCCTACCTCTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCC
GAGCTGAACTCTATCATCCGACAGCAGCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTG
GGGCTGCAGCCGCCTTCGCTGCCGGCGGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAG
GAAGACAAGAACGGGCACGATGGTGACACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGA
GGGGGGACAGAGGGGAGACAGAGGCACGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGT
ATTTATGGTGGCCGCCGGCGGGGGCCCCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTC
CCCTGCAGCCTGGTTAGGTGGATACCTGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAG
CAAGACCTCGCGAAGCGCAGCAGCCCCGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCC
TGGTACTGCATGCACGCAATGCTAGCTGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCAC
CTCCACCTGCCCCACTCACCACCTCTGCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACG
AGGGACGAGCTTAGCTGAGCTGGGAGGAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACT


>30299_30299_2_FGFR3-AES_FGFR3_chr4_1808660_ENST00000260795_AES_chr19_3061254_ENST00000327141_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL
PLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_3_FGFR3-AES_FGFR3_chr4_1808660_ENST00000340107_AES_chr19_3061254_ENST00000221561_length(transcript)=4012nt_BP=2536nt
GTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACGGACGCACCGGCGGGCCGCCGGCCGGAGGGACGGGGCGGGAGCTG
GGCCCGCGGACAGCGAGCCGGAGCGGGAGCCGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGGCGCCCGCCTCCCGC
CGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGC
CTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGC
GGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGG
GGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCA
GGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGT
GACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACG
GCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTC
CATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCAT
GGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGT
GCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTG
CAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTA
CGTTACCGTGCTCAAGTCCTGGATCAGTGAGAGTGTGGAGGCCGACGTGCGCCTCCGCCTGGCCAATGTGTCGGAGCGGGACGGGGGCGA
GTACCTCTGTCGAGCCACCAATTTCATAGGCGTGGCCGAGAAGGCCTTTTGGCTGAGCGTTCACGGGCCCCGAGCAGCCGAGGAGGAGCT
GGTGGAGGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTCATCCTGGTGGTGGCGGCTGT
GACGCTCTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGCTTCCCGCTCAAGCGACAGGT
GTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAA
TGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTT
CGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGA
TGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAACATCATCAACCTGCTGGG
CGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCC
GGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCG
GGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGAT
CGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCC
TGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTC
CCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCT
GTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTAC
CGTGACGTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCGCATCAAAGACGAATTTCA
GCTACTGCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCAGCGTCACTATGTGATGTA
CTACGAGATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGATTTGTGCCCAGGTCCTGCC
CTACCTCTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGAGCTGAACTCTATCATCCG
ACAGCAGCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGGGCTGCAGCCGCCTTCGCT
GCCGGCGGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGAAGACAAGAACGGGCACGA
TGGTGACACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGGGGGGACAGAGGGGAGACA
GAGGCACGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTATTTATGGTGGCCGCCGGCG
GGGGCCCCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCCCTGCAGCCTGGTTAGGTG
GATACCTGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCAAGACCTCGCGAAGCGCAG
CAGCCCCGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTGGTACTGCATGCACGCAAT
GCTAGCTGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCTCCACCTGCCCCACTCACC
ACCTCTGCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAGGGACGAGCTTAGCTGAGC
TGGGAGGAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACTAAAGTTGTCTTGGTTTTTAT
TTTATTATTATTTTTTTCTTTTTCCAGTATACTAGCTTGTCTTTTAAGAAAGGGGATATTAAAAAAAAAAAAAGACAAAAGTGTTTTTAA
AAAAAAGCAACACCCACACCTGTGTCTGTATATAGTCAGCTTATCTCGTGTTCAATCGTCTGATCTCTACAGAGAGAAGTGGAAAATGCT
GTATCAAGGGTGGGCTTAGCTGTGCCTTTCCAATAAAGATGTGAGAAGCTTC

>30299_30299_3_FGFR3-AES_FGFR3_chr4_1808660_ENST00000340107_AES_chr19_3061254_ENST00000221561_length(amino acids)=959AA_BP=613
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEK
AFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPL
VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME
MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRD
LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL
KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECD
KLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQAL
ALPLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_4_FGFR3-AES_FGFR3_chr4_1808660_ENST00000340107_AES_chr19_3061254_ENST00000327141_length(transcript)=3760nt_BP=2536nt
GTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACGGACGCACCGGCGGGCCGCCGGCCGGAGGGACGGGGCGGGAGCTG
GGCCCGCGGACAGCGAGCCGGAGCGGGAGCCGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGGCGCCCGCCTCCCGC
CGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGC
CTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGC
GGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGG
GGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCA
GGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGT
GACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACG
GCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTC
CATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCAT
GGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGT
GCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTG
CAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTA
CGTTACCGTGCTCAAGTCCTGGATCAGTGAGAGTGTGGAGGCCGACGTGCGCCTCCGCCTGGCCAATGTGTCGGAGCGGGACGGGGGCGA
GTACCTCTGTCGAGCCACCAATTTCATAGGCGTGGCCGAGAAGGCCTTTTGGCTGAGCGTTCACGGGCCCCGAGCAGCCGAGGAGGAGCT
GGTGGAGGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTCATCCTGGTGGTGGCGGCTGT
GACGCTCTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGCTTCCCGCTCAAGCGACAGGT
GTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAA
TGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTT
CGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGA
TGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAACATCATCAACCTGCTGGG
CGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCC
GGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCG
GGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGAT
CGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCC
TGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTC
CCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCT
GTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTAC
CGTGACGTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCGCATCAAAGACGAATTTCA
GCTACTGCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCAGCGTCACTATGTGATGTA
CTACGAGATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGATTTGTGCCCAGGTCCTGCC
CTACCTCTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGAGCTGAACTCTATCATCCG
ACAGCAGCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGGGCTGCAGCCGCCTTCGCT
GCCGGCGGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGAAGACAAGAACGGGCACGA
TGGTGACACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGGGGGGACAGAGGGGAGACA
GAGGCACGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTATTTATGGTGGCCGCCGGCG
GGGGCCCCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCCCTGCAGCCTGGTTAGGTG
GATACCTGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCAAGACCTCGCGAAGCGCAG
CAGCCCCGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTGGTACTGCATGCACGCAAT
GCTAGCTGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCTCCACCTGCCCCACTCACC
ACCTCTGCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAGGGACGAGCTTAGCTGAGC
TGGGAGGAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACT

>30299_30299_4_FGFR3-AES_FGFR3_chr4_1808660_ENST00000340107_AES_chr19_3061254_ENST00000327141_length(amino acids)=959AA_BP=613
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEK
AFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPL
VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME
MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRD
LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL
KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECD
KLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQAL
ALPLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_5_FGFR3-AES_FGFR3_chr4_1808660_ENST00000352904_AES_chr19_3061254_ENST00000221561_length(transcript)=3453nt_BP=1977nt
CGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGCCTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTG
GCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGCGGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAG
CAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGGGGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGAT
GGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCAGGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTAC
AGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGTGACAGACGCTCCATCCTCGGGAGATGACGAAGACGGG
GAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACGGCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCG
GCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTCCATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGC
GAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCATGGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACC
TGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGTGCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCG
GGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTGCAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGG
CTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTACGTTACCGTGCTCAAGGTGTCCCTGGAGTCCAACGCG
TCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAATGTCTCCGAGCTCGAGCTG
CCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCG
GAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGATGCCACTGACAAGGACCTG
TCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAACATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGG
CCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTC
GACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCC
TCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCC
CGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGA
GTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCT
GTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
TGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGGC
TCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCGCATCAAAGACGAATTTCAGCTACTGCAAGCTCAGTAC
CACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCAGCGTCACTATGTGATGTACTACGAGATGTCCTACGGC
TTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGATTTGTGCCCAGGTCCTGCCCTACCTCTCCCAAGAGCAC
CAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGAGCTGAACTCTATCATCCGACAGCAGCTCCAAGCCCAC
CAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGGGCTGCAGCCGCCTTCGCTGCCGGCGGTCAGCGCAGGC
ACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGAAGACAAGAACGGGCACGATGGTGACACCCACCAGGAG
GATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGGGGGGACAGAGGGGAGACAGAGGCACGGAGAGAAAGGA
ATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTATTTATGGTGGCCGCCGGCGGGGGCCCCAGCCCAGCTTG
CAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCCCTGCAGCCTGGTTAGGTGGATACCTGCCCTGACATGT
GAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCAAGACCTCGCGAAGCGCAGCAGCCCCGGCCCTTCCCCC
GTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTGGTACTGCATGCACGCAATGCTAGCTGCCCCTTTCCCG
TCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCTCCACCTGCCCCACTCACCACCTCTGCTAGTTCCAGAC
ACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAGGGACGAGCTTAGCTGAGCTGGGAGGAGCAGGGTGAGG
GTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACTAAAGTTGTCTTGGTTTTTATTTTATTATTATTTTTTTCT
TTTTCCAGTATACTAGCTTGTCTTTTAAGAAAGGGGATATTAAAAAAAAAAAAAGACAAAAGTGTTTTTAAAAAAAAGCAACACCCACAC
CTGTGTCTGTATATAGTCAGCTTATCTCGTGTTCAATCGTCTGATCTCTACAGAGAGAAGTGGAAAATGCTGTATCAAGGGTGGGCTTAG
CTGTGCCTTTCCAATAAAGATGTGAGAAGCTTC

>30299_30299_5_FGFR3-AES_FGFR3_chr4_1808660_ENST00000352904_AES_chr19_3061254_ENST00000221561_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG
LLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_6_FGFR3-AES_FGFR3_chr4_1808660_ENST00000352904_AES_chr19_3061254_ENST00000327141_length(transcript)=3201nt_BP=1977nt
CGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGCCTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTG
GCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGCGGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAG
CAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGGGGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGAT
GGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCAGGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTAC
AGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGTGACAGACGCTCCATCCTCGGGAGATGACGAAGACGGG
GAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACGGCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCG
GCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTCCATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGC
GAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCATGGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACC
TGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGTGCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCG
GGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTGCAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGG
CTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTACGTTACCGTGCTCAAGGTGTCCCTGGAGTCCAACGCG
TCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAATGTCTCCGAGCTCGAGCTG
CCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCG
GAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGATGCCACTGACAAGGACCTG
TCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAACATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGG
CCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTC
GACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCC
TCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCC
CGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGA
GTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCT
GTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
TGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGGC
TCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCGCATCAAAGACGAATTTCAGCTACTGCAAGCTCAGTAC
CACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCAGCGTCACTATGTGATGTACTACGAGATGTCCTACGGC
TTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGATTTGTGCCCAGGTCCTGCCCTACCTCTCCCAAGAGCAC
CAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGAGCTGAACTCTATCATCCGACAGCAGCTCCAAGCCCAC
CAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGGGCTGCAGCCGCCTTCGCTGCCGGCGGTCAGCGCAGGC
ACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGAAGACAAGAACGGGCACGATGGTGACACCCACCAGGAG
GATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGGGGGGACAGAGGGGAGACAGAGGCACGGAGAGAAAGGA
ATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTATTTATGGTGGCCGCCGGCGGGGGCCCCAGCCCAGCTTG
CAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCCCTGCAGCCTGGTTAGGTGGATACCTGCCCTGACATGT
GAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCAAGACCTCGCGAAGCGCAGCAGCCCCGGCCCTTCCCCC
GTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTGGTACTGCATGCACGCAATGCTAGCTGCCCCTTTCCCG
TCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCTCCACCTGCCCCACTCACCACCTCTGCTAGTTCCAGAC
ACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAGGGACGAGCTTAGCTGAGCTGGGAGGAGCAGGGTGAGG
GTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACT

>30299_30299_6_FGFR3-AES_FGFR3_chr4_1808660_ENST00000352904_AES_chr19_3061254_ENST00000327141_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG
LLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_7_FGFR3-AES_FGFR3_chr4_1808660_ENST00000412135_AES_chr19_3061254_ENST00000221561_length(transcript)=3670nt_BP=2194nt
GTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACGGACGCACCGGCGGGCCGCCGGCCGGAGGGACGGGGCGGGAGCTG
GGCCCGCGGACAGCGAGCCGGAGCGGGAGCCGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGGCGCCCGCCTCCCGC
CGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGC
CTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGC
GGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGG
GGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCA
GGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGT
GACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACG
GCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTC
CATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCAT
GGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGT
GCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTG
CAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTA
CGTTACCGTGCTCAAGGTGTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGA
GGGCCCCACGCTGGCCAATGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCC
CCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGT
GAAGATGCTGAAAGACGATGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAA
CATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCT
GCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTG
TGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGA
GGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCC
CGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGAT
CTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGC
CAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGA
CCTGGACCGTGTCCTTACCGTGACGTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCG
CATCAAAGACGAATTTCAGCTACTGCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCA
GCGTCACTATGTGATGTACTACGAGATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGAT
TTGTGCCCAGGTCCTGCCCTACCTCTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGA
GCTGAACTCTATCATCCGACAGCAGCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGG
GCTGCAGCCGCCTTCGCTGCCGGCGGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGA
AGACAAGAACGGGCACGATGGTGACACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGG
GGGGACAGAGGGGAGACAGAGGCACGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTAT
TTATGGTGGCCGCCGGCGGGGGCCCCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCC
CTGCAGCCTGGTTAGGTGGATACCTGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCA
AGACCTCGCGAAGCGCAGCAGCCCCGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTG
GTACTGCATGCACGCAATGCTAGCTGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCT
CCACCTGCCCCACTCACCACCTCTGCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAG
GGACGAGCTTAGCTGAGCTGGGAGGAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACTAA
AGTTGTCTTGGTTTTTATTTTATTATTATTTTTTTCTTTTTCCAGTATACTAGCTTGTCTTTTAAGAAAGGGGATATTAAAAAAAAAAAA
AGACAAAAGTGTTTTTAAAAAAAAGCAACACCCACACCTGTGTCTGTATATAGTCAGCTTATCTCGTGTTCAATCGTCTGATCTCTACAG
AGAGAAGTGGAAAATGCTGTATCAAGGGTGGGCTTAGCTGTGCCTTTCCAATAAAGATGTGAGAAGCTTC

>30299_30299_7_FGFR3-AES_FGFR3_chr4_1808660_ENST00000412135_AES_chr19_3061254_ENST00000221561_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG
LLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_8_FGFR3-AES_FGFR3_chr4_1808660_ENST00000412135_AES_chr19_3061254_ENST00000327141_length(transcript)=3418nt_BP=2194nt
GTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACGGACGCACCGGCGGGCCGCCGGCCGGAGGGACGGGGCGGGAGCTG
GGCCCGCGGACAGCGAGCCGGAGCGGGAGCCGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGGCGCCCGCCTCCCGC
CGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGC
CTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGC
GGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGG
GGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCA
GGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGT
GACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACG
GCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTC
CATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCAT
GGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGT
GCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTG
CAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTA
CGTTACCGTGCTCAAGGTGTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGA
GGGCCCCACGCTGGCCAATGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCC
CCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGT
GAAGATGCTGAAAGACGATGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAA
CATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCT
GCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTG
TGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGA
GGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCC
CGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGAT
CTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGC
CAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGA
CCTGGACCGTGTCCTTACCGTGACGTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCG
CATCAAAGACGAATTTCAGCTACTGCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCA
GCGTCACTATGTGATGTACTACGAGATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGAT
TTGTGCCCAGGTCCTGCCCTACCTCTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGA
GCTGAACTCTATCATCCGACAGCAGCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGG
GCTGCAGCCGCCTTCGCTGCCGGCGGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGA
AGACAAGAACGGGCACGATGGTGACACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGG
GGGGACAGAGGGGAGACAGAGGCACGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTAT
TTATGGTGGCCGCCGGCGGGGGCCCCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCC
CTGCAGCCTGGTTAGGTGGATACCTGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCA
AGACCTCGCGAAGCGCAGCAGCCCCGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTG
GTACTGCATGCACGCAATGCTAGCTGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCT
CCACCTGCCCCACTCACCACCTCTGCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAG
GGACGAGCTTAGCTGAGCTGGGAGGAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACT

>30299_30299_8_FGFR3-AES_FGFR3_chr4_1808660_ENST00000412135_AES_chr19_3061254_ENST00000327141_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG
LLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_9_FGFR3-AES_FGFR3_chr4_1808660_ENST00000440486_AES_chr19_3061254_ENST00000221561_length(transcript)=4006nt_BP=2530nt
GTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACGGACGCACCGGCGGGCCGCCGGCCGGAGGGACGGGGCGGGAGCTG
GGCCCGCGGACAGCGAGCCGGAGCGGGAGCCGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGGCGCCCGCCTCCCGC
CGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGC
CTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGC
GGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGG
GGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCA
GGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGT
GACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACG
GCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTC
CATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCAT
GGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGT
GCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTG
CAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTA
CGTTACCGTGCTCAAGACGGCGGGCGCTAACACCACCGACAAGGAGCTAGAGGTTCTCTCCTTGCACAACGTCACCTTTGAGGACGCCGG
GGAGTACACCTGCCTGGCGGGCAATTCTATTGGGTTTTCTCATCACTCTGCGTGGCTGGTGGTGCTGCCAGCCGAGGAGGAGCTGGTGGA
GGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTCATCCTGGTGGTGGCGGCTGTGACGCT
CTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGCTTCCCGCTCAAGCGACAGGTGTCCCT
GGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAATGTCTC
CGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTTCGGCCA
GGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGATGCCAC
TGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAACATCATCAACCTGCTGGGCGCCTG
CACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCCGGGCCT
GGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCAT
GGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGATCGCAGA
CTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGC
CTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTA
CCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACAT
GATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGAC
GTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCGCATCAAAGACGAATTTCAGCTACT
GCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCAGCGTCACTATGTGATGTACTACGA
GATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGATTTGTGCCCAGGTCCTGCCCTACCT
CTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGAGCTGAACTCTATCATCCGACAGCA
GCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGGGCTGCAGCCGCCTTCGCTGCCGGC
GGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGAAGACAAGAACGGGCACGATGGTGA
CACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGGGGGGACAGAGGGGAGACAGAGGCA
CGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTATTTATGGTGGCCGCCGGCGGGGGCC
CCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCCCTGCAGCCTGGTTAGGTGGATACC
TGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCAAGACCTCGCGAAGCGCAGCAGCCC
CGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTGGTACTGCATGCACGCAATGCTAGC
TGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCTCCACCTGCCCCACTCACCACCTCT
GCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAGGGACGAGCTTAGCTGAGCTGGGAG
GAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACTAAAGTTGTCTTGGTTTTTATTTTATT
ATTATTTTTTTCTTTTTCCAGTATACTAGCTTGTCTTTTAAGAAAGGGGATATTAAAAAAAAAAAAAGACAAAAGTGTTTTTAAAAAAAA
GCAACACCCACACCTGTGTCTGTATATAGTCAGCTTATCTCGTGTTCAATCGTCTGATCTCTACAGAGAGAAGTGGAAAATGCTGTATCA
AGGGTGGGCTTAGCTGTGCCTTTCCAATAAAGATGTGAGAAGCTTC

>30299_30299_9_FGFR3-AES_FGFR3_chr4_1808660_ENST00000440486_AES_chr19_3061254_ENST00000221561_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL
PLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_10_FGFR3-AES_FGFR3_chr4_1808660_ENST00000440486_AES_chr19_3061254_ENST00000327141_length(transcript)=3754nt_BP=2530nt
GTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACGGACGCACCGGCGGGCCGCCGGCCGGAGGGACGGGGCGGGAGCTG
GGCCCGCGGACAGCGAGCCGGAGCGGGAGCCGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGGCGCCCGCCTCCCGC
CGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGC
CTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGC
GGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGG
GGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCA
GGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGT
GACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACG
GCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTC
CATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCAT
GGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGT
GCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTG
CAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTA
CGTTACCGTGCTCAAGACGGCGGGCGCTAACACCACCGACAAGGAGCTAGAGGTTCTCTCCTTGCACAACGTCACCTTTGAGGACGCCGG
GGAGTACACCTGCCTGGCGGGCAATTCTATTGGGTTTTCTCATCACTCTGCGTGGCTGGTGGTGCTGCCAGCCGAGGAGGAGCTGGTGGA
GGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTCATCCTGGTGGTGGCGGCTGTGACGCT
CTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGCTTCCCGCTCAAGCGACAGGTGTCCCT
GGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAATGTCTC
CGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTTCGGCCA
GGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGATGCCAC
TGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAACATCATCAACCTGCTGGGCGCCTG
CACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCCGGGCCT
GGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCAT
GGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGATCGCAGA
CTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGC
CTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTA
CCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACAT
GATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGAC
GTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCGCATCAAAGACGAATTTCAGCTACT
GCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCAGCGTCACTATGTGATGTACTACGA
GATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGATTTGTGCCCAGGTCCTGCCCTACCT
CTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGAGCTGAACTCTATCATCCGACAGCA
GCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGGGCTGCAGCCGCCTTCGCTGCCGGC
GGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGAAGACAAGAACGGGCACGATGGTGA
CACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGGGGGGACAGAGGGGAGACAGAGGCA
CGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTATTTATGGTGGCCGCCGGCGGGGGCC
CCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCCCTGCAGCCTGGTTAGGTGGATACC
TGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCAAGACCTCGCGAAGCGCAGCAGCCC
CGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTGGTACTGCATGCACGCAATGCTAGC
TGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCTCCACCTGCCCCACTCACCACCTCT
GCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAGGGACGAGCTTAGCTGAGCTGGGAG
GAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACT

>30299_30299_10_FGFR3-AES_FGFR3_chr4_1808660_ENST00000440486_AES_chr19_3061254_ENST00000327141_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL
PLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_11_FGFR3-AES_FGFR3_chr4_1808661_ENST00000260795_AES_chr19_3061255_ENST00000221561_length(transcript)=3852nt_BP=2376nt
TCTCCCGAGCGGCGCCCGCCTCCCGCCGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCC
CCCGCCCCCGCCATGGGCGCCCCTGCCTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGG
ACGGAGCAGCGCGTCGTGGGGCGAGCGGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCT
GTGGAGCTGAGCTGTCCCCCGCCCGGGGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGT
GTCCTGGTGGGGCCCCAGCGGCTGCAGGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGC
GTACTGTGCCACTTCAGTGTGCGGGTGACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTG
GACACAGGGGCCCCTTACTGGACACGGCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGC
CCAGCCGCTGGCAACCCCACTCCCTCCATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTG
CGGCATCAGCAGTGGAGCCTGGTCATGGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGC
ATCCGGCAGACGTACACGCTGGACGTGCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTG
CTGGGCAGCGACGTGGAGTTCCACTGCAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGC
AAGGTGGGCCCGGACGGCACACCCTACGTTACCGTGCTCAAGACGGCGGGCGCTAACACCACCGACAAGGAGCTAGAGGTTCTCTCCTTG
CACAACGTCACCTTTGAGGACGCCGGGGAGTACACCTGCCTGGCGGGCAATTCTATTGGGTTTTCTCATCACTCTGCGTGGCTGGTGGTG
CTGCCAGCCGAGGAGGAGCTGGTGGAGGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTC
ATCCTGGTGGTGGCGGCTGTGACGCTCTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGC
TTCCCGCTCAAGCGACAGGTGTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGG
GAGGGCCCCACGCTGGCCAATGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAG
CCCCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCC
GTGAAGATGCTGAAAGACGATGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAA
AACATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTT
CTGCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCC
TGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACC
GAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTG
CCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAG
ATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCC
GCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAG
GACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGAC
CGCATCAAAGACGAATTTCAGCTACTGCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATG
CAGCGTCACTATGTGATGTACTACGAGATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGG
ATTTGTGCCCAGGTCCTGCCCTACCTCTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCC
GAGCTGAACTCTATCATCCGACAGCAGCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTG
GGGCTGCAGCCGCCTTCGCTGCCGGCGGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAG
GAAGACAAGAACGGGCACGATGGTGACACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGA
GGGGGGACAGAGGGGAGACAGAGGCACGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGT
ATTTATGGTGGCCGCCGGCGGGGGCCCCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTC
CCCTGCAGCCTGGTTAGGTGGATACCTGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAG
CAAGACCTCGCGAAGCGCAGCAGCCCCGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCC
TGGTACTGCATGCACGCAATGCTAGCTGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCAC
CTCCACCTGCCCCACTCACCACCTCTGCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACG
AGGGACGAGCTTAGCTGAGCTGGGAGGAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACT
AAAGTTGTCTTGGTTTTTATTTTATTATTATTTTTTTCTTTTTCCAGTATACTAGCTTGTCTTTTAAGAAAGGGGATATTAAAAAAAAAA
AAAGACAAAAGTGTTTTTAAAAAAAAGCAACACCCACACCTGTGTCTGTATATAGTCAGCTTATCTCGTGTTCAATCGTCTGATCTCTAC
AGAGAGAAGTGGAAAATGCTGTATCAAGGGTGGGCTTAGCTGTGCCTTTCCAATAAAGATGTGAGAAGCTTC

>30299_30299_11_FGFR3-AES_FGFR3_chr4_1808661_ENST00000260795_AES_chr19_3061255_ENST00000221561_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL
PLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_12_FGFR3-AES_FGFR3_chr4_1808661_ENST00000260795_AES_chr19_3061255_ENST00000327141_length(transcript)=3600nt_BP=2376nt
TCTCCCGAGCGGCGCCCGCCTCCCGCCGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCC
CCCGCCCCCGCCATGGGCGCCCCTGCCTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGG
ACGGAGCAGCGCGTCGTGGGGCGAGCGGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCT
GTGGAGCTGAGCTGTCCCCCGCCCGGGGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGT
GTCCTGGTGGGGCCCCAGCGGCTGCAGGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGC
GTACTGTGCCACTTCAGTGTGCGGGTGACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTG
GACACAGGGGCCCCTTACTGGACACGGCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGC
CCAGCCGCTGGCAACCCCACTCCCTCCATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTG
CGGCATCAGCAGTGGAGCCTGGTCATGGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGC
ATCCGGCAGACGTACACGCTGGACGTGCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTG
CTGGGCAGCGACGTGGAGTTCCACTGCAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGC
AAGGTGGGCCCGGACGGCACACCCTACGTTACCGTGCTCAAGACGGCGGGCGCTAACACCACCGACAAGGAGCTAGAGGTTCTCTCCTTG
CACAACGTCACCTTTGAGGACGCCGGGGAGTACACCTGCCTGGCGGGCAATTCTATTGGGTTTTCTCATCACTCTGCGTGGCTGGTGGTG
CTGCCAGCCGAGGAGGAGCTGGTGGAGGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTC
ATCCTGGTGGTGGCGGCTGTGACGCTCTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGC
TTCCCGCTCAAGCGACAGGTGTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGG
GAGGGCCCCACGCTGGCCAATGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAG
CCCCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCC
GTGAAGATGCTGAAAGACGATGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAA
AACATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTT
CTGCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCC
TGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACC
GAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTG
CCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAG
ATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCC
GCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAG
GACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGAC
CGCATCAAAGACGAATTTCAGCTACTGCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATG
CAGCGTCACTATGTGATGTACTACGAGATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGG
ATTTGTGCCCAGGTCCTGCCCTACCTCTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCC
GAGCTGAACTCTATCATCCGACAGCAGCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTG
GGGCTGCAGCCGCCTTCGCTGCCGGCGGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAG
GAAGACAAGAACGGGCACGATGGTGACACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGA
GGGGGGACAGAGGGGAGACAGAGGCACGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGT
ATTTATGGTGGCCGCCGGCGGGGGCCCCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTC
CCCTGCAGCCTGGTTAGGTGGATACCTGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAG
CAAGACCTCGCGAAGCGCAGCAGCCCCGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCC
TGGTACTGCATGCACGCAATGCTAGCTGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCAC
CTCCACCTGCCCCACTCACCACCTCTGCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACG
AGGGACGAGCTTAGCTGAGCTGGGAGGAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACT


>30299_30299_12_FGFR3-AES_FGFR3_chr4_1808661_ENST00000260795_AES_chr19_3061255_ENST00000327141_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL
PLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_13_FGFR3-AES_FGFR3_chr4_1808661_ENST00000340107_AES_chr19_3061255_ENST00000221561_length(transcript)=4012nt_BP=2536nt
GTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACGGACGCACCGGCGGGCCGCCGGCCGGAGGGACGGGGCGGGAGCTG
GGCCCGCGGACAGCGAGCCGGAGCGGGAGCCGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGGCGCCCGCCTCCCGC
CGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGC
CTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGC
GGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGG
GGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCA
GGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGT
GACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACG
GCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTC
CATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCAT
GGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGT
GCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTG
CAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTA
CGTTACCGTGCTCAAGTCCTGGATCAGTGAGAGTGTGGAGGCCGACGTGCGCCTCCGCCTGGCCAATGTGTCGGAGCGGGACGGGGGCGA
GTACCTCTGTCGAGCCACCAATTTCATAGGCGTGGCCGAGAAGGCCTTTTGGCTGAGCGTTCACGGGCCCCGAGCAGCCGAGGAGGAGCT
GGTGGAGGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTCATCCTGGTGGTGGCGGCTGT
GACGCTCTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGCTTCCCGCTCAAGCGACAGGT
GTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAA
TGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTT
CGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGA
TGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAACATCATCAACCTGCTGGG
CGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCC
GGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCG
GGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGAT
CGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCC
TGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTC
CCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCT
GTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTAC
CGTGACGTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCGCATCAAAGACGAATTTCA
GCTACTGCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCAGCGTCACTATGTGATGTA
CTACGAGATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGATTTGTGCCCAGGTCCTGCC
CTACCTCTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGAGCTGAACTCTATCATCCG
ACAGCAGCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGGGCTGCAGCCGCCTTCGCT
GCCGGCGGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGAAGACAAGAACGGGCACGA
TGGTGACACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGGGGGGACAGAGGGGAGACA
GAGGCACGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTATTTATGGTGGCCGCCGGCG
GGGGCCCCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCCCTGCAGCCTGGTTAGGTG
GATACCTGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCAAGACCTCGCGAAGCGCAG
CAGCCCCGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTGGTACTGCATGCACGCAAT
GCTAGCTGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCTCCACCTGCCCCACTCACC
ACCTCTGCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAGGGACGAGCTTAGCTGAGC
TGGGAGGAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACTAAAGTTGTCTTGGTTTTTAT
TTTATTATTATTTTTTTCTTTTTCCAGTATACTAGCTTGTCTTTTAAGAAAGGGGATATTAAAAAAAAAAAAAGACAAAAGTGTTTTTAA
AAAAAAGCAACACCCACACCTGTGTCTGTATATAGTCAGCTTATCTCGTGTTCAATCGTCTGATCTCTACAGAGAGAAGTGGAAAATGCT
GTATCAAGGGTGGGCTTAGCTGTGCCTTTCCAATAAAGATGTGAGAAGCTTC

>30299_30299_13_FGFR3-AES_FGFR3_chr4_1808661_ENST00000340107_AES_chr19_3061255_ENST00000221561_length(amino acids)=959AA_BP=613
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEK
AFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPL
VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME
MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRD
LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL
KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECD
KLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQAL
ALPLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_14_FGFR3-AES_FGFR3_chr4_1808661_ENST00000340107_AES_chr19_3061255_ENST00000327141_length(transcript)=3760nt_BP=2536nt
GTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACGGACGCACCGGCGGGCCGCCGGCCGGAGGGACGGGGCGGGAGCTG
GGCCCGCGGACAGCGAGCCGGAGCGGGAGCCGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGGCGCCCGCCTCCCGC
CGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGC
CTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGC
GGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGG
GGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCA
GGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGT
GACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACG
GCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTC
CATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCAT
GGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGT
GCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTG
CAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTA
CGTTACCGTGCTCAAGTCCTGGATCAGTGAGAGTGTGGAGGCCGACGTGCGCCTCCGCCTGGCCAATGTGTCGGAGCGGGACGGGGGCGA
GTACCTCTGTCGAGCCACCAATTTCATAGGCGTGGCCGAGAAGGCCTTTTGGCTGAGCGTTCACGGGCCCCGAGCAGCCGAGGAGGAGCT
GGTGGAGGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTCATCCTGGTGGTGGCGGCTGT
GACGCTCTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGCTTCCCGCTCAAGCGACAGGT
GTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAA
TGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTT
CGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGA
TGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAACATCATCAACCTGCTGGG
CGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCC
GGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCG
GGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGAT
CGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCC
TGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTC
CCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCT
GTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTAC
CGTGACGTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCGCATCAAAGACGAATTTCA
GCTACTGCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCAGCGTCACTATGTGATGTA
CTACGAGATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGATTTGTGCCCAGGTCCTGCC
CTACCTCTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGAGCTGAACTCTATCATCCG
ACAGCAGCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGGGCTGCAGCCGCCTTCGCT
GCCGGCGGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGAAGACAAGAACGGGCACGA
TGGTGACACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGGGGGGACAGAGGGGAGACA
GAGGCACGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTATTTATGGTGGCCGCCGGCG
GGGGCCCCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCCCTGCAGCCTGGTTAGGTG
GATACCTGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCAAGACCTCGCGAAGCGCAG
CAGCCCCGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTGGTACTGCATGCACGCAAT
GCTAGCTGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCTCCACCTGCCCCACTCACC
ACCTCTGCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAGGGACGAGCTTAGCTGAGC
TGGGAGGAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACT

>30299_30299_14_FGFR3-AES_FGFR3_chr4_1808661_ENST00000340107_AES_chr19_3061255_ENST00000327141_length(amino acids)=959AA_BP=613
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEK
AFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPL
VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME
MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRD
LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL
KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECD
KLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQAL
ALPLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_15_FGFR3-AES_FGFR3_chr4_1808661_ENST00000352904_AES_chr19_3061255_ENST00000221561_length(transcript)=3453nt_BP=1977nt
CGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGCCTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTG
GCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGCGGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAG
CAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGGGGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGAT
GGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCAGGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTAC
AGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGTGACAGACGCTCCATCCTCGGGAGATGACGAAGACGGG
GAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACGGCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCG
GCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTCCATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGC
GAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCATGGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACC
TGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGTGCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCG
GGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTGCAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGG
CTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTACGTTACCGTGCTCAAGGTGTCCCTGGAGTCCAACGCG
TCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAATGTCTCCGAGCTCGAGCTG
CCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCG
GAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGATGCCACTGACAAGGACCTG
TCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAACATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGG
CCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTC
GACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCC
TCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCC
CGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGA
GTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCT
GTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
TGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGGC
TCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCGCATCAAAGACGAATTTCAGCTACTGCAAGCTCAGTAC
CACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCAGCGTCACTATGTGATGTACTACGAGATGTCCTACGGC
TTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGATTTGTGCCCAGGTCCTGCCCTACCTCTCCCAAGAGCAC
CAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGAGCTGAACTCTATCATCCGACAGCAGCTCCAAGCCCAC
CAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGGGCTGCAGCCGCCTTCGCTGCCGGCGGTCAGCGCAGGC
ACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGAAGACAAGAACGGGCACGATGGTGACACCCACCAGGAG
GATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGGGGGGACAGAGGGGAGACAGAGGCACGGAGAGAAAGGA
ATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTATTTATGGTGGCCGCCGGCGGGGGCCCCAGCCCAGCTTG
CAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCCCTGCAGCCTGGTTAGGTGGATACCTGCCCTGACATGT
GAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCAAGACCTCGCGAAGCGCAGCAGCCCCGGCCCTTCCCCC
GTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTGGTACTGCATGCACGCAATGCTAGCTGCCCCTTTCCCG
TCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCTCCACCTGCCCCACTCACCACCTCTGCTAGTTCCAGAC
ACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAGGGACGAGCTTAGCTGAGCTGGGAGGAGCAGGGTGAGG
GTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACTAAAGTTGTCTTGGTTTTTATTTTATTATTATTTTTTTCT
TTTTCCAGTATACTAGCTTGTCTTTTAAGAAAGGGGATATTAAAAAAAAAAAAAGACAAAAGTGTTTTTAAAAAAAAGCAACACCCACAC
CTGTGTCTGTATATAGTCAGCTTATCTCGTGTTCAATCGTCTGATCTCTACAGAGAGAAGTGGAAAATGCTGTATCAAGGGTGGGCTTAG
CTGTGCCTTTCCAATAAAGATGTGAGAAGCTTC

>30299_30299_15_FGFR3-AES_FGFR3_chr4_1808661_ENST00000352904_AES_chr19_3061255_ENST00000221561_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG
LLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_16_FGFR3-AES_FGFR3_chr4_1808661_ENST00000352904_AES_chr19_3061255_ENST00000327141_length(transcript)=3201nt_BP=1977nt
CGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGCCTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTG
GCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGCGGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAG
CAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGGGGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGAT
GGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCAGGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTAC
AGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGTGACAGACGCTCCATCCTCGGGAGATGACGAAGACGGG
GAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACGGCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCG
GCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTCCATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGC
GAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCATGGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACC
TGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGTGCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCG
GGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTGCAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGG
CTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTACGTTACCGTGCTCAAGGTGTCCCTGGAGTCCAACGCG
TCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAATGTCTCCGAGCTCGAGCTG
CCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCG
GAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGATGCCACTGACAAGGACCTG
TCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAACATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGG
CCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTC
GACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCC
TCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCC
CGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGA
GTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCT
GTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
TGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGGC
TCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCGCATCAAAGACGAATTTCAGCTACTGCAAGCTCAGTAC
CACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCAGCGTCACTATGTGATGTACTACGAGATGTCCTACGGC
TTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGATTTGTGCCCAGGTCCTGCCCTACCTCTCCCAAGAGCAC
CAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGAGCTGAACTCTATCATCCGACAGCAGCTCCAAGCCCAC
CAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGGGCTGCAGCCGCCTTCGCTGCCGGCGGTCAGCGCAGGC
ACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGAAGACAAGAACGGGCACGATGGTGACACCCACCAGGAG
GATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGGGGGGACAGAGGGGAGACAGAGGCACGGAGAGAAAGGA
ATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTATTTATGGTGGCCGCCGGCGGGGGCCCCAGCCCAGCTTG
CAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCCCTGCAGCCTGGTTAGGTGGATACCTGCCCTGACATGT
GAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCAAGACCTCGCGAAGCGCAGCAGCCCCGGCCCTTCCCCC
GTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTGGTACTGCATGCACGCAATGCTAGCTGCCCCTTTCCCG
TCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCTCCACCTGCCCCACTCACCACCTCTGCTAGTTCCAGAC
ACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAGGGACGAGCTTAGCTGAGCTGGGAGGAGCAGGGTGAGG
GTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACT

>30299_30299_16_FGFR3-AES_FGFR3_chr4_1808661_ENST00000352904_AES_chr19_3061255_ENST00000327141_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG
LLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_17_FGFR3-AES_FGFR3_chr4_1808661_ENST00000412135_AES_chr19_3061255_ENST00000221561_length(transcript)=3670nt_BP=2194nt
GTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACGGACGCACCGGCGGGCCGCCGGCCGGAGGGACGGGGCGGGAGCTG
GGCCCGCGGACAGCGAGCCGGAGCGGGAGCCGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGGCGCCCGCCTCCCGC
CGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGC
CTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGC
GGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGG
GGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCA
GGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGT
GACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACG
GCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTC
CATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCAT
GGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGT
GCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTG
CAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTA
CGTTACCGTGCTCAAGGTGTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGA
GGGCCCCACGCTGGCCAATGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCC
CCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGT
GAAGATGCTGAAAGACGATGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAA
CATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCT
GCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTG
TGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGA
GGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCC
CGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGAT
CTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGC
CAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGA
CCTGGACCGTGTCCTTACCGTGACGTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCG
CATCAAAGACGAATTTCAGCTACTGCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCA
GCGTCACTATGTGATGTACTACGAGATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGAT
TTGTGCCCAGGTCCTGCCCTACCTCTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGA
GCTGAACTCTATCATCCGACAGCAGCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGG
GCTGCAGCCGCCTTCGCTGCCGGCGGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGA
AGACAAGAACGGGCACGATGGTGACACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGG
GGGGACAGAGGGGAGACAGAGGCACGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTAT
TTATGGTGGCCGCCGGCGGGGGCCCCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCC
CTGCAGCCTGGTTAGGTGGATACCTGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCA
AGACCTCGCGAAGCGCAGCAGCCCCGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTG
GTACTGCATGCACGCAATGCTAGCTGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCT
CCACCTGCCCCACTCACCACCTCTGCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAG
GGACGAGCTTAGCTGAGCTGGGAGGAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACTAA
AGTTGTCTTGGTTTTTATTTTATTATTATTTTTTTCTTTTTCCAGTATACTAGCTTGTCTTTTAAGAAAGGGGATATTAAAAAAAAAAAA
AGACAAAAGTGTTTTTAAAAAAAAGCAACACCCACACCTGTGTCTGTATATAGTCAGCTTATCTCGTGTTCAATCGTCTGATCTCTACAG
AGAGAAGTGGAAAATGCTGTATCAAGGGTGGGCTTAGCTGTGCCTTTCCAATAAAGATGTGAGAAGCTTC

>30299_30299_17_FGFR3-AES_FGFR3_chr4_1808661_ENST00000412135_AES_chr19_3061255_ENST00000221561_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG
LLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_18_FGFR3-AES_FGFR3_chr4_1808661_ENST00000412135_AES_chr19_3061255_ENST00000327141_length(transcript)=3418nt_BP=2194nt
GTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACGGACGCACCGGCGGGCCGCCGGCCGGAGGGACGGGGCGGGAGCTG
GGCCCGCGGACAGCGAGCCGGAGCGGGAGCCGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGGCGCCCGCCTCCCGC
CGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGC
CTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGC
GGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGG
GGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCA
GGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGT
GACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACG
GCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTC
CATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCAT
GGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGT
GCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTG
CAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTA
CGTTACCGTGCTCAAGGTGTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGA
GGGCCCCACGCTGGCCAATGTCTCCGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCC
CCTTGGGGAGGGCTGCTTCGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGT
GAAGATGCTGAAAGACGATGCCACTGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAA
CATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCT
GCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTG
TGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGA
GGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCC
CGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGAT
CTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGC
CAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGA
CCTGGACCGTGTCCTTACCGTGACGTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCG
CATCAAAGACGAATTTCAGCTACTGCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCA
GCGTCACTATGTGATGTACTACGAGATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGAT
TTGTGCCCAGGTCCTGCCCTACCTCTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGA
GCTGAACTCTATCATCCGACAGCAGCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGG
GCTGCAGCCGCCTTCGCTGCCGGCGGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGA
AGACAAGAACGGGCACGATGGTGACACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGG
GGGGACAGAGGGGAGACAGAGGCACGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTAT
TTATGGTGGCCGCCGGCGGGGGCCCCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCC
CTGCAGCCTGGTTAGGTGGATACCTGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCA
AGACCTCGCGAAGCGCAGCAGCCCCGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTG
GTACTGCATGCACGCAATGCTAGCTGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCT
CCACCTGCCCCACTCACCACCTCTGCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAG
GGACGAGCTTAGCTGAGCTGGGAGGAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACT

>30299_30299_18_FGFR3-AES_FGFR3_chr4_1808661_ENST00000412135_AES_chr19_3061255_ENST00000327141_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG
LLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_19_FGFR3-AES_FGFR3_chr4_1808661_ENST00000440486_AES_chr19_3061255_ENST00000221561_length(transcript)=4006nt_BP=2530nt
GTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACGGACGCACCGGCGGGCCGCCGGCCGGAGGGACGGGGCGGGAGCTG
GGCCCGCGGACAGCGAGCCGGAGCGGGAGCCGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGGCGCCCGCCTCCCGC
CGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGC
CTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGC
GGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGG
GGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCA
GGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGT
GACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACG
GCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTC
CATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCAT
GGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGT
GCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTG
CAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTA
CGTTACCGTGCTCAAGACGGCGGGCGCTAACACCACCGACAAGGAGCTAGAGGTTCTCTCCTTGCACAACGTCACCTTTGAGGACGCCGG
GGAGTACACCTGCCTGGCGGGCAATTCTATTGGGTTTTCTCATCACTCTGCGTGGCTGGTGGTGCTGCCAGCCGAGGAGGAGCTGGTGGA
GGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTCATCCTGGTGGTGGCGGCTGTGACGCT
CTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGCTTCCCGCTCAAGCGACAGGTGTCCCT
GGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAATGTCTC
CGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTTCGGCCA
GGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGATGCCAC
TGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAACATCATCAACCTGCTGGGCGCCTG
CACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCCGGGCCT
GGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCAT
GGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGATCGCAGA
CTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGC
CTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTA
CCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACAT
GATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGAC
GTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCGCATCAAAGACGAATTTCAGCTACT
GCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCAGCGTCACTATGTGATGTACTACGA
GATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGATTTGTGCCCAGGTCCTGCCCTACCT
CTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGAGCTGAACTCTATCATCCGACAGCA
GCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGGGCTGCAGCCGCCTTCGCTGCCGGC
GGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGAAGACAAGAACGGGCACGATGGTGA
CACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGGGGGGACAGAGGGGAGACAGAGGCA
CGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTATTTATGGTGGCCGCCGGCGGGGGCC
CCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCCCTGCAGCCTGGTTAGGTGGATACC
TGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCAAGACCTCGCGAAGCGCAGCAGCCC
CGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTGGTACTGCATGCACGCAATGCTAGC
TGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCTCCACCTGCCCCACTCACCACCTCT
GCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAGGGACGAGCTTAGCTGAGCTGGGAG
GAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACTAAAGTTGTCTTGGTTTTTATTTTATT
ATTATTTTTTTCTTTTTCCAGTATACTAGCTTGTCTTTTAAGAAAGGGGATATTAAAAAAAAAAAAAGACAAAAGTGTTTTTAAAAAAAA
GCAACACCCACACCTGTGTCTGTATATAGTCAGCTTATCTCGTGTTCAATCGTCTGATCTCTACAGAGAGAAGTGGAAAATGCTGTATCA
AGGGTGGGCTTAGCTGTGCCTTTCCAATAAAGATGTGAGAAGCTTC

>30299_30299_19_FGFR3-AES_FGFR3_chr4_1808661_ENST00000440486_AES_chr19_3061255_ENST00000221561_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL
PLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

--------------------------------------------------------------
>30299_30299_20_FGFR3-AES_FGFR3_chr4_1808661_ENST00000440486_AES_chr19_3061255_ENST00000327141_length(transcript)=3754nt_BP=2530nt
GTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACGGACGCACCGGCGGGCCGCCGGCCGGAGGGACGGGGCGGGAGCTG
GGCCCGCGGACAGCGAGCCGGAGCGGGAGCCGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGGCGCCCGCCTCCCGC
CGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGCGGCCCCCGCCCCCGCCATGGGCGCCCCTGC
CTGCGCCCTCGCGCTCTGCGTGGCCGTGGCCATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGC
GGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGATGCTGTGGAGCTGAGCTGTCCCCCGCCCGG
GGGTGGTCCCATGGGGCCCACTGTCTGGGTCAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGGGGCCCCAGCGGCTGCA
GGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACGCAGCGCGTACTGTGCCACTTCAGTGTGCGGGT
GACAGACGCTCCATCCTCGGGAGATGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTGGACACG
GCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCGCTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTC
CATCTCCTGGCTGAAGAACGGCAGGGAGTTCCGCGGCGAGCACCGCATTGGAGGCATCAAGCTGCGGCATCAGCAGTGGAGCCTGGTCAT
GGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGTTTGGCAGCATCCGGCAGACGTACACGCTGGACGT
GCTGGAGCGCTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTGCCGGCCAACCAGACGGCGGTGCTGGGCAGCGACGTGGAGTTCCACTG
CAAGGTGTACAGTGACGCACAGCCCCACATCCAGTGGCTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTA
CGTTACCGTGCTCAAGACGGCGGGCGCTAACACCACCGACAAGGAGCTAGAGGTTCTCTCCTTGCACAACGTCACCTTTGAGGACGCCGG
GGAGTACACCTGCCTGGCGGGCAATTCTATTGGGTTTTCTCATCACTCTGCGTGGCTGGTGGTGCTGCCAGCCGAGGAGGAGCTGGTGGA
GGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTTCTTCCTGTTCATCCTGGTGGTGGCGGCTGTGACGCT
CTGCCGCCTGCGCAGCCCCCCCAAGAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGCTTCCCGCTCAAGCGACAGGTGTCCCT
GGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAAGGCTGTCCTCAGGGGAGGGCCCCACGCTGGCCAATGTCTC
CGAGCTCGAGCTGCCTGCCGACCCCAAATGGGAGCTGTCTCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGGGCTGCTTCGGCCA
GGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACCGGGCCGCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGATGCCAC
TGACAAGGACCTGTCGGACCTGGTGTCTGAGATGGAGATGATGAAGATGATCGGGAAACACAAAAACATCATCAACCTGCTGGGCGCCTG
CACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGTACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCCGGGCCT
GGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCAT
GGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGATCGCAGA
CTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGC
CTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTA
CCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACAT
GATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGAC
GTCCACCGACGGCTCCTCGCACCTACCCCAGCAACTCAAATTCACCACCTCGGACTCCTGCGACCGCATCAAAGACGAATTTCAGCTACT
GCAAGCTCAGTACCACAGCCTCAAGCTCGAATGTGACAAGTTGGCCAGTGAGAAGTCAGAGATGCAGCGTCACTATGTGATGTACTACGA
GATGTCCTACGGCTTGAACATCGAGATGCACAAACAGGCTGAGATCGTCAAAAGGCTGAACGGGATTTGTGCCCAGGTCCTGCCCTACCT
CTCCCAAGAGCACCAGCAGCAGGTCTTGGGAGCCATTGAGAGGGCCAAGCAGGTCACCGCTCCCGAGCTGAACTCTATCATCCGACAGCA
GCTCCAAGCCCACCAGCTGTCCCAGCTGCAGGCCCTGGCCCTGCCCTTGACCCCACTACCCGTGGGGCTGCAGCCGCCTTCGCTGCCGGC
GGTCAGCGCAGGCACCGGCCTCCTCTCGCTGTCCGCGCTGGGTTCCCAGGCCCACCTCTCCAAGGAAGACAAGAACGGGCACGATGGTGA
CACCCACCAGGAGGATGATGGCGAGAAGTCGGATTAGCAGGGGGCCGGGACAGGGAGGTTGGGAGGGGGGACAGAGGGGAGACAGAGGCA
CGGAGAGAAAGGAATGTTTAGCACAAGACACAGCGGAGCTCGGGATTGGCTAAACTCCCATAGTATTTATGGTGGCCGCCGGCGGGGGCC
CCAGCCCAGCTTGCAGGCCACCTCTAGCTTTCTTCCTACCCCATTCCCGGCTTCCCTCCTCCTCCCCTGCAGCCTGGTTAGGTGGATACC
TGCCCTGACATGTGAGGCAAGCTAAGGCCTGGAGGGTCAGATGGGAGACCAGGTCCCAAGGGAGCAAGACCTCGCGAAGCGCAGCAGCCC
CGGCCCTTCCCCCGTTTTGAACATGTGTAACCGACAGTCTGCCTGGGCCACAGCCCTCTCACCCTGGTACTGCATGCACGCAATGCTAGC
TGCCCCTTTCCCGTCCTGGGCACCCCGAGTCTCCCCCGACCCCGGGTCCCAGGTATGCTCCCACCTCCACCTGCCCCACTCACCACCTCT
GCTAGTTCCAGACACCTCCACGCCCACCTGGTCCTCTCCCATCGCCCACAAAAGGGGGGGCACGAGGGACGAGCTTAGCTGAGCTGGGAG
GAGCAGGGTGAGGGTGGGCGACCCAGGATTCCCCCTCCCCTTCCCAAATAAAGATGAGGGTACT

>30299_30299_20_FGFR3-AES_FGFR3_chr4_1808661_ENST00000440486_AES_chr19_3061255_ENST00000327141_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL
PLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

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Fusion Gene PPI Analysis for FGFR3-AES


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGFR3-AES


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGFR3P22607DB06589PazopanibInhibitorSmall moleculeApproved
HgeneFGFR3P22607DB06589PazopanibInhibitorSmall moleculeApproved
HgeneFGFR3P22607DB09079NintedanibInhibitorSmall moleculeApproved
HgeneFGFR3P22607DB09079NintedanibInhibitorSmall moleculeApproved
HgeneFGFR3P22607DB08901PonatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR3P22607DB08901PonatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR3P22607DB09078LenvatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR3P22607DB09078LenvatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR3P22607DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR3P22607DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR3P22607DB12147ErdafitinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR3P22607DB12147ErdafitinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR3P22607DB15102PemigatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR3P22607DB15102PemigatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR3P22607DB15685SelpercatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR3P22607DB15685SelpercatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for FGFR3-AES


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR3C0001080Achondroplasia13CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR3C0410529Hypochondroplasia (disorder)10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR3C1864436Muenke Syndrome9CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR3C1868678THANATOPHORIC DYSPLASIA, TYPE I (disorder)9CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR3C2677099CROUZON SYNDROME WITH ACANTHOSIS NIGRICANS (disorder)7CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR3C0005684Malignant neoplasm of urinary bladder6CGI;CTD_human;UNIPROT
HgeneFGFR3C0005695Bladder Neoplasm4CGI;CTD_human
HgeneFGFR3C1300257Thanatophoric dysplasia, type 24CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR3C1864852CATSHL syndrome4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR3C2674173Achondroplasia, Severe, With Developmental Delay And Acanthosis Nigricans3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR3C0265269Lacrimoauriculodentodigital syndrome2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR3C0007138Carcinoma, Transitional Cell1CTD_human
HgeneFGFR3C0008924Cleft upper lip1CTD_human
HgeneFGFR3C0008925Cleft Palate1CTD_human
HgeneFGFR3C0014544Epilepsy1GENOMICS_ENGLAND
HgeneFGFR3C0014547Epilepsies, Partial1GENOMICS_ENGLAND
HgeneFGFR3C0022603Seborrheic keratosis1UNIPROT
HgeneFGFR3C0026764Multiple Myeloma1CGI;CTD_human
HgeneFGFR3C0036631Seminoma1CTD_human
HgeneFGFR3C0039743Thanatophoric Dysplasia1CTD_human
HgeneFGFR3C0152423Congenital small ears1GENOMICS_ENGLAND
HgeneFGFR3C0206726gliosarcoma1ORPHANET
HgeneFGFR3C0221356Brachycephaly1ORPHANET
HgeneFGFR3C0265529Plagiocephaly1ORPHANET
HgeneFGFR3C0334082NEVUS, EPIDERMAL (disorder)1CTD_human;UNIPROT
HgeneFGFR3C0334588Giant Cell Glioblastoma1ORPHANET
HgeneFGFR3C0406803Syringocystadenoma Papilliferum1GENOMICS_ENGLAND
HgeneFGFR3C1336708Testicular Germ Cell Tumor1CTD_human;UNIPROT
HgeneFGFR3C1837218Cleft palate, isolated1CTD_human
HgeneFGFR3C4048328cervical cancer1CTD_human;UNIPROT