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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGFR2-OFD1 (FusionGDB2 ID:HG2263TG8481)

Fusion Gene Summary for FGFR2-OFD1

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR2-OFD1
Fusion gene ID: hg2263tg8481
HgeneTgene
Gene symbol

FGFR2

OFD1

Gene ID

2263

8481

Gene namefibroblast growth factor receptor 2OFD1 centriole and centriolar satellite protein
SynonymsBBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK2571-7A|CXorf5|JBTS10|RP23|SGBS2
Cytomap('FGFR2')('OFD1')

10q26.13

Xp22.2

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14oral-facial-digital syndrome 1 proteinJoubert syndrome type 10protein 71-7A
Modification date2020032220200320
UniProtAcc

P21802

.
Ensembl transtripts involved in fusion geneENST00000346997, ENST00000351936, 
ENST00000356226, ENST00000357555, 
ENST00000358487, ENST00000360144, 
ENST00000369056, ENST00000369059, 
ENST00000369060, ENST00000369061, 
ENST00000457416, ENST00000478859, 
ENST00000359354, ENST00000490349, 
Fusion gene scores* DoF score24 X 20 X 12=57607 X 9 X 3=189
# samples 389
** MAII scorelog2(38/5760*10)=-3.92199748799873
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/189*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGFR2 [Title/Abstract] AND OFD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGFR2(123243212)-OFD1(13754597), # samples:3
Anticipated loss of major functional domain due to fusion event.FGFR2-OFD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR2-OFD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR2-OFD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR2-OFD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR2-OFD1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FGFR2-OFD1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FGFR2-OFD1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR2

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

HgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

HgeneFGFR2

GO:0046777

protein autophosphorylation

15629145


check buttonFusion gene breakpoints across FGFR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across OFD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-BJ-A0Z0-01AFGFR2chr10

123243212

-OFD1chrX

13754597

+
ChimerDB4THCATCGA-BJ-A0Z0FGFR2chr10

123243211

-OFD1chrX

13754596

+


Top

Fusion Gene ORF analysis for FGFR2-OFD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000346997ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-3UTRENST00000346997ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-3UTRENST00000351936ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-3UTRENST00000351936ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-3UTRENST00000356226ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-3UTRENST00000356226ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-3UTRENST00000357555ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-3UTRENST00000357555ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-3UTRENST00000358487ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-3UTRENST00000358487ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-3UTRENST00000360144ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-3UTRENST00000360144ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-3UTRENST00000369056ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-3UTRENST00000369056ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-3UTRENST00000369059ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-3UTRENST00000369059ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-3UTRENST00000369060ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-3UTRENST00000369060ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-3UTRENST00000369061ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-3UTRENST00000369061ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-3UTRENST00000457416ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-3UTRENST00000457416ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-3UTRENST00000478859ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-3UTRENST00000478859ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000346997ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000346997ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000346997ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000346997ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000351936ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000351936ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000351936ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000351936ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000356226ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000356226ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000356226ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000356226ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000357555ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000357555ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000357555ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000357555ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000358487ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000358487ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000358487ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000358487ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000360144ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000360144ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000360144ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000360144ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000369056ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000369056ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000369056ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000369056ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000369059ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000369059ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000369059ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000369059ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000369060ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000369060ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000369060ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000369060ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000369061ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000369061ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000369061ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000369061ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000457416ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000457416ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000457416ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000457416ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000478859ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000478859ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
5CDS-5UTRENST00000478859ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
5CDS-5UTRENST00000478859ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000351936ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000351936ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000351936ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000351936ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000356226ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000356226ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000356226ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000356226ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000357555ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000357555ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000357555ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000357555ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000358487ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000358487ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000358487ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000358487ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000360144ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000360144ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000360144ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000360144ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000369059ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000369059ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000369059ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000369059ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000369060ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000369060ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000369060ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000369060ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000457416ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000457416ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000457416ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000457416ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000478859ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000478859ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
Frame-shiftENST00000478859ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
Frame-shiftENST00000478859ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
In-frameENST00000346997ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
In-frameENST00000346997ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
In-frameENST00000346997ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
In-frameENST00000346997ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
In-frameENST00000369056ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
In-frameENST00000369056ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
In-frameENST00000369056ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
In-frameENST00000369056ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
In-frameENST00000369061ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
In-frameENST00000369061ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
In-frameENST00000369061ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
In-frameENST00000369061ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
intron-3CDSENST00000359354ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
intron-3CDSENST00000359354ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
intron-3CDSENST00000359354ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
intron-3CDSENST00000359354ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
intron-3CDSENST00000490349ENST00000380550FGFR2chr10

123243212

-OFD1chrX

13754597

+
intron-3CDSENST00000490349ENST00000380550FGFR2chr10

123243211

-OFD1chrX

13754596

+
intron-3CDSENST00000490349ENST00000398395FGFR2chr10

123243212

-OFD1chrX

13754597

+
intron-3CDSENST00000490349ENST00000398395FGFR2chr10

123243211

-OFD1chrX

13754596

+
intron-3UTRENST00000359354ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
intron-3UTRENST00000359354ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
intron-3UTRENST00000490349ENST00000490265FGFR2chr10

123243212

-OFD1chrX

13754597

+
intron-3UTRENST00000490349ENST00000490265FGFR2chr10

123243211

-OFD1chrX

13754596

+
intron-5UTRENST00000359354ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
intron-5UTRENST00000359354ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
intron-5UTRENST00000359354ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
intron-5UTRENST00000359354ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+
intron-5UTRENST00000490349ENST00000340096FGFR2chr10

123243212

-OFD1chrX

13754597

+
intron-5UTRENST00000490349ENST00000340096FGFR2chr10

123243211

-OFD1chrX

13754596

+
intron-5UTRENST00000490349ENST00000380567FGFR2chr10

123243212

-OFD1chrX

13754597

+
intron-5UTRENST00000490349ENST00000380567FGFR2chr10

123243211

-OFD1chrX

13754596

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369061FGFR2chr10123243212-ENST00000380550OFD1chrX13754597+517621154849221624
ENST00000369061FGFR2chr10123243212-ENST00000398395OFD1chrX13754597+326121154831071019
ENST00000346997FGFR2chr10123243212-ENST00000380550OFD1chrX13754597+536823071251141700
ENST00000346997FGFR2chr10123243212-ENST00000398395OFD1chrX13754597+345323071232991095
ENST00000369056FGFR2chr10123243212-ENST00000380550OFD1chrX13754597+538923282451351703
ENST00000369056FGFR2chr10123243212-ENST00000398395OFD1chrX13754597+347423282433201098
ENST00000369061FGFR2chr10123243211-ENST00000380550OFD1chrX13754596+517621154849221624
ENST00000369061FGFR2chr10123243211-ENST00000398395OFD1chrX13754596+326121154831071019
ENST00000346997FGFR2chr10123243211-ENST00000380550OFD1chrX13754596+536823071251141700
ENST00000346997FGFR2chr10123243211-ENST00000398395OFD1chrX13754596+345323071232991095
ENST00000369056FGFR2chr10123243211-ENST00000380550OFD1chrX13754596+538923282451351703
ENST00000369056FGFR2chr10123243211-ENST00000398395OFD1chrX13754596+347423282433201098

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369061ENST00000380550FGFR2chr10123243212-OFD1chrX13754597+0.0006897510.99931026
ENST00000369061ENST00000398395FGFR2chr10123243212-OFD1chrX13754597+0.0011812870.9988187
ENST00000346997ENST00000380550FGFR2chr10123243212-OFD1chrX13754597+0.0004883270.9995117
ENST00000346997ENST00000398395FGFR2chr10123243212-OFD1chrX13754597+0.0005467530.99945325
ENST00000369056ENST00000380550FGFR2chr10123243212-OFD1chrX13754597+0.000517330.99948263
ENST00000369056ENST00000398395FGFR2chr10123243212-OFD1chrX13754597+0.0003545420.9996455
ENST00000369061ENST00000380550FGFR2chr10123243211-OFD1chrX13754596+0.0006897510.99931026
ENST00000369061ENST00000398395FGFR2chr10123243211-OFD1chrX13754596+0.0011812870.9988187
ENST00000346997ENST00000380550FGFR2chr10123243211-OFD1chrX13754596+0.0004883270.9995117
ENST00000346997ENST00000398395FGFR2chr10123243211-OFD1chrX13754596+0.0005467530.99945325
ENST00000369056ENST00000380550FGFR2chr10123243211-OFD1chrX13754596+0.000517330.99948263
ENST00000369056ENST00000398395FGFR2chr10123243211-OFD1chrX13754596+0.0003545420.9996455

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Fusion Genomic Features for FGFR2-OFD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FGFR2chr10123243211-OFD1chrX13754596+0.0118934720.9881065
FGFR2chr10123243211-OFD1chrX13754596+0.0118934720.9881065
FGFR2chr10123243211-OFD1chrX13754596+0.0118934720.9881065
FGFR2chr10123243211-OFD1chrX13754596+0.0118934720.9881065

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FGFR2-OFD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:123243212/chrX:13754597)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR2

P21802

.
FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123243211chrX:13754596ENST00000346997-1617154_247765820.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243211chrX:13754596ENST00000346997-1617256_358765820.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243211chrX:13754596ENST00000346997-161725_125765820.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243211chrX:13754596ENST00000351936-1718154_247765786.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243211chrX:13754596ENST00000351936-1718256_358765786.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243211chrX:13754596ENST00000351936-171825_125765786.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243211chrX:13754596ENST00000356226-1516154_247650705.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243211chrX:13754596ENST00000356226-1516256_358650705.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243211chrX:13754596ENST00000356226-151625_125650705.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243211chrX:13754596ENST00000357555-1617154_247678708.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243211chrX:13754596ENST00000357555-1617256_358678708.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243211chrX:13754596ENST00000357555-161725_125678708.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243211chrX:13754596ENST00000358487-1718154_247767822.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243211chrX:13754596ENST00000358487-1718256_358767822.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243211chrX:13754596ENST00000358487-171825_125767822.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243211chrX:13754596ENST00000358487-1718481_770767822.0DomainProtein kinase
HgeneFGFR2chr10:123243211chrX:13754596ENST00000360144-1617154_247679681.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243211chrX:13754596ENST00000360144-1617256_358679681.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243211chrX:13754596ENST00000360144-161725_125679681.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369056-1617154_247768770.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369056-1617256_358768770.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369056-161725_125768770.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369056-1617481_770768770.0DomainProtein kinase
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369060-1516154_247651706.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369060-1516256_358651706.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369060-151625_125651706.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369061-1415154_247655710.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369061-1415256_358655710.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369061-141525_125655710.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243211chrX:13754596ENST00000457416-1718154_247768823.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243211chrX:13754596ENST00000457416-1718256_358768823.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243211chrX:13754596ENST00000457416-171825_125768823.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243211chrX:13754596ENST00000457416-1718481_770768823.0DomainProtein kinase
HgeneFGFR2chr10:123243212chrX:13754597ENST00000346997-1617154_247765820.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chrX:13754597ENST00000346997-1617256_358765820.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chrX:13754597ENST00000346997-161725_125765820.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chrX:13754597ENST00000351936-1718154_247765786.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chrX:13754597ENST00000351936-1718256_358765786.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chrX:13754597ENST00000351936-171825_125765786.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chrX:13754597ENST00000356226-1516154_247650705.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chrX:13754597ENST00000356226-1516256_358650705.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chrX:13754597ENST00000356226-151625_125650705.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chrX:13754597ENST00000357555-1617154_247678708.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chrX:13754597ENST00000357555-1617256_358678708.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chrX:13754597ENST00000357555-161725_125678708.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chrX:13754597ENST00000358487-1718154_247767822.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chrX:13754597ENST00000358487-1718256_358767822.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chrX:13754597ENST00000358487-171825_125767822.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chrX:13754597ENST00000358487-1718481_770767822.0DomainProtein kinase
HgeneFGFR2chr10:123243212chrX:13754597ENST00000360144-1617154_247679681.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chrX:13754597ENST00000360144-1617256_358679681.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chrX:13754597ENST00000360144-161725_125679681.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369056-1617154_247768770.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369056-1617256_358768770.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369056-161725_125768770.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369056-1617481_770768770.0DomainProtein kinase
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369060-1516154_247651706.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369060-1516256_358651706.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369060-151625_125651706.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369061-1415154_247655710.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369061-1415256_358655710.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369061-141525_125655710.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chrX:13754597ENST00000457416-1718154_247768823.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chrX:13754597ENST00000457416-1718256_358768823.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chrX:13754597ENST00000457416-171825_125768823.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chrX:13754597ENST00000457416-1718481_770768823.0DomainProtein kinase
HgeneFGFR2chr10:123243211chrX:13754596ENST00000346997-1617487_495765820.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000346997-1617565_567765820.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000351936-1718487_495765786.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000351936-1718565_567765786.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000356226-1516487_495650705.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000356226-1516565_567650705.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000357555-1617487_495678708.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000357555-1617565_567678708.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000358487-1718487_495767822.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000358487-1718565_567767822.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000360144-1617487_495679681.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000360144-1617565_567679681.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369056-1617487_495768770.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369056-1617565_567768770.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369060-1516487_495651706.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369060-1516565_567651706.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369061-1415487_495655710.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369061-1415565_567655710.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000457416-1718487_495768823.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000457416-1718565_567768823.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000346997-1617487_495765820.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000346997-1617565_567765820.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000351936-1718487_495765786.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000351936-1718565_567765786.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000356226-1516487_495650705.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000356226-1516565_567650705.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000357555-1617487_495678708.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000357555-1617565_567678708.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000358487-1718487_495767822.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000358487-1718565_567767822.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000360144-1617487_495679681.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000360144-1617565_567679681.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369056-1617487_495768770.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369056-1617565_567768770.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369060-1516487_495651706.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369060-1516565_567651706.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369061-1415487_495655710.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369061-1415565_567655710.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000457416-1718487_495768823.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000457416-1718565_567768823.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000346997-1617161_178765820.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243211chrX:13754596ENST00000351936-1718161_178765786.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243211chrX:13754596ENST00000356226-1516161_178650705.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243211chrX:13754596ENST00000357555-1617161_178678708.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243211chrX:13754596ENST00000358487-1718161_178767822.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243211chrX:13754596ENST00000360144-1617161_178679681.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369056-1617161_178768770.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369060-1516161_178651706.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369061-1415161_178655710.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243211chrX:13754596ENST00000457416-1718161_178768823.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chrX:13754597ENST00000346997-1617161_178765820.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chrX:13754597ENST00000351936-1718161_178765786.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chrX:13754597ENST00000356226-1516161_178650705.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chrX:13754597ENST00000357555-1617161_178678708.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chrX:13754597ENST00000358487-1718161_178767822.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chrX:13754597ENST00000360144-1617161_178679681.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369056-1617161_178768770.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369060-1516161_178651706.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369061-1415161_178655710.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chrX:13754597ENST00000457416-1718161_178768823.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243211chrX:13754596ENST00000346997-161722_377765820.0Topological domainExtracellular
HgeneFGFR2chr10:123243211chrX:13754596ENST00000351936-171822_377765786.0Topological domainExtracellular
HgeneFGFR2chr10:123243211chrX:13754596ENST00000356226-151622_377650705.0Topological domainExtracellular
HgeneFGFR2chr10:123243211chrX:13754596ENST00000357555-161722_377678708.0Topological domainExtracellular
HgeneFGFR2chr10:123243211chrX:13754596ENST00000358487-171822_377767822.0Topological domainExtracellular
HgeneFGFR2chr10:123243211chrX:13754596ENST00000360144-161722_377679681.0Topological domainExtracellular
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369056-161722_377768770.0Topological domainExtracellular
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369060-151622_377651706.0Topological domainExtracellular
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369061-141522_377655710.0Topological domainExtracellular
HgeneFGFR2chr10:123243211chrX:13754596ENST00000457416-171822_377768823.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chrX:13754597ENST00000346997-161722_377765820.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chrX:13754597ENST00000351936-171822_377765786.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chrX:13754597ENST00000356226-151622_377650705.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chrX:13754597ENST00000357555-161722_377678708.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chrX:13754597ENST00000358487-171822_377767822.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chrX:13754597ENST00000360144-161722_377679681.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369056-161722_377768770.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369060-151622_377651706.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369061-141522_377655710.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chrX:13754597ENST00000457416-171822_377768823.0Topological domainExtracellular
HgeneFGFR2chr10:123243211chrX:13754596ENST00000346997-1617378_398765820.0TransmembraneHelical
HgeneFGFR2chr10:123243211chrX:13754596ENST00000351936-1718378_398765786.0TransmembraneHelical
HgeneFGFR2chr10:123243211chrX:13754596ENST00000356226-1516378_398650705.0TransmembraneHelical
HgeneFGFR2chr10:123243211chrX:13754596ENST00000357555-1617378_398678708.0TransmembraneHelical
HgeneFGFR2chr10:123243211chrX:13754596ENST00000358487-1718378_398767822.0TransmembraneHelical
HgeneFGFR2chr10:123243211chrX:13754596ENST00000360144-1617378_398679681.0TransmembraneHelical
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369056-1617378_398768770.0TransmembraneHelical
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369060-1516378_398651706.0TransmembraneHelical
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369061-1415378_398655710.0TransmembraneHelical
HgeneFGFR2chr10:123243211chrX:13754596ENST00000457416-1718378_398768823.0TransmembraneHelical
HgeneFGFR2chr10:123243212chrX:13754597ENST00000346997-1617378_398765820.0TransmembraneHelical
HgeneFGFR2chr10:123243212chrX:13754597ENST00000351936-1718378_398765786.0TransmembraneHelical
HgeneFGFR2chr10:123243212chrX:13754597ENST00000356226-1516378_398650705.0TransmembraneHelical
HgeneFGFR2chr10:123243212chrX:13754597ENST00000357555-1617378_398678708.0TransmembraneHelical
HgeneFGFR2chr10:123243212chrX:13754597ENST00000358487-1718378_398767822.0TransmembraneHelical
HgeneFGFR2chr10:123243212chrX:13754597ENST00000360144-1617378_398679681.0TransmembraneHelical
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369056-1617378_398768770.0TransmembraneHelical
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369060-1516378_398651706.0TransmembraneHelical
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369061-1415378_398655710.0TransmembraneHelical
HgeneFGFR2chr10:123243212chrX:13754597ENST00000457416-1718378_398768823.0TransmembraneHelical
TgeneOFD1chr10:123243211chrX:13754596ENST00000340096123189_557371013.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243211chrX:13754596ENST00000340096123622_662371013.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243211chrX:13754596ENST00000340096123867_956371013.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243211chrX:13754596ENST00000380550122189_55737973.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243211chrX:13754596ENST00000380550122622_66237973.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243211chrX:13754596ENST00000380550122867_95637973.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243211chrX:13754596ENST00000398395111189_55737368.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243211chrX:13754596ENST00000398395111622_66237368.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243211chrX:13754596ENST00000398395111867_95637368.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243212chrX:13754597ENST00000340096123189_557371013.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243212chrX:13754597ENST00000340096123622_662371013.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243212chrX:13754597ENST00000340096123867_956371013.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243212chrX:13754597ENST00000380550122189_55737973.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243212chrX:13754597ENST00000380550122622_66237973.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243212chrX:13754597ENST00000380550122867_95637973.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243212chrX:13754597ENST00000398395111189_55737368.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243212chrX:13754597ENST00000398395111622_66237368.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243212chrX:13754597ENST00000398395111867_95637368.0Coiled coilOntology_term=ECO:0000255
TgeneOFD1chr10:123243211chrX:13754596ENST0000034009612370_102371013.0DomainLisH
TgeneOFD1chr10:123243211chrX:13754596ENST0000038055012270_10237973.0DomainLisH
TgeneOFD1chr10:123243211chrX:13754596ENST0000039839511170_10237368.0DomainLisH
TgeneOFD1chr10:123243212chrX:13754597ENST0000034009612370_102371013.0DomainLisH
TgeneOFD1chr10:123243212chrX:13754597ENST0000038055012270_10237973.0DomainLisH
TgeneOFD1chr10:123243212chrX:13754597ENST0000039839511170_10237368.0DomainLisH
TgeneOFD1chr10:123243211chrX:13754596ENST00000340096123609_665371013.0RegionNote=Mediates homooligomerization
TgeneOFD1chr10:123243211chrX:13754596ENST00000380550122609_66537973.0RegionNote=Mediates homooligomerization
TgeneOFD1chr10:123243211chrX:13754596ENST00000398395111609_66537368.0RegionNote=Mediates homooligomerization
TgeneOFD1chr10:123243212chrX:13754597ENST00000340096123609_665371013.0RegionNote=Mediates homooligomerization
TgeneOFD1chr10:123243212chrX:13754597ENST00000380550122609_66537973.0RegionNote=Mediates homooligomerization
TgeneOFD1chr10:123243212chrX:13754597ENST00000398395111609_66537368.0RegionNote=Mediates homooligomerization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123243211chrX:13754596ENST00000346997-1617481_770765820.0DomainProtein kinase
HgeneFGFR2chr10:123243211chrX:13754596ENST00000351936-1718481_770765786.0DomainProtein kinase
HgeneFGFR2chr10:123243211chrX:13754596ENST00000356226-1516481_770650705.0DomainProtein kinase
HgeneFGFR2chr10:123243211chrX:13754596ENST00000357555-1617481_770678708.0DomainProtein kinase
HgeneFGFR2chr10:123243211chrX:13754596ENST00000359354-17154_2470255.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243211chrX:13754596ENST00000359354-17256_3580255.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243211chrX:13754596ENST00000359354-1725_1250255.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243211chrX:13754596ENST00000359354-17481_7700255.0DomainProtein kinase
HgeneFGFR2chr10:123243211chrX:13754596ENST00000360144-1617481_770679681.0DomainProtein kinase
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369060-1516481_770651706.0DomainProtein kinase
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369061-1415481_770655710.0DomainProtein kinase
HgeneFGFR2chr10:123243212chrX:13754597ENST00000346997-1617481_770765820.0DomainProtein kinase
HgeneFGFR2chr10:123243212chrX:13754597ENST00000351936-1718481_770765786.0DomainProtein kinase
HgeneFGFR2chr10:123243212chrX:13754597ENST00000356226-1516481_770650705.0DomainProtein kinase
HgeneFGFR2chr10:123243212chrX:13754597ENST00000357555-1617481_770678708.0DomainProtein kinase
HgeneFGFR2chr10:123243212chrX:13754597ENST00000359354-17154_2470255.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chrX:13754597ENST00000359354-17256_3580255.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chrX:13754597ENST00000359354-1725_1250255.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chrX:13754597ENST00000359354-17481_7700255.0DomainProtein kinase
HgeneFGFR2chr10:123243212chrX:13754597ENST00000360144-1617481_770679681.0DomainProtein kinase
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369060-1516481_770651706.0DomainProtein kinase
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369061-1415481_770655710.0DomainProtein kinase
HgeneFGFR2chr10:123243211chrX:13754596ENST00000359354-17487_4950255.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000359354-17565_5670255.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000359354-17487_4950255.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chrX:13754597ENST00000359354-17565_5670255.0Nucleotide bindingATP
HgeneFGFR2chr10:123243211chrX:13754596ENST00000359354-17161_1780255.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chrX:13754597ENST00000359354-17161_1780255.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243211chrX:13754596ENST00000346997-1617399_821765820.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243211chrX:13754596ENST00000351936-1718399_821765786.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243211chrX:13754596ENST00000356226-1516399_821650705.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243211chrX:13754596ENST00000357555-1617399_821678708.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243211chrX:13754596ENST00000358487-1718399_821767822.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243211chrX:13754596ENST00000359354-1722_3770255.0Topological domainExtracellular
HgeneFGFR2chr10:123243211chrX:13754596ENST00000359354-17399_8210255.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243211chrX:13754596ENST00000360144-1617399_821679681.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369056-1617399_821768770.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369060-1516399_821651706.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243211chrX:13754596ENST00000369061-1415399_821655710.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243211chrX:13754596ENST00000457416-1718399_821768823.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chrX:13754597ENST00000346997-1617399_821765820.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chrX:13754597ENST00000351936-1718399_821765786.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chrX:13754597ENST00000356226-1516399_821650705.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chrX:13754597ENST00000357555-1617399_821678708.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chrX:13754597ENST00000358487-1718399_821767822.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chrX:13754597ENST00000359354-1722_3770255.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chrX:13754597ENST00000359354-17399_8210255.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chrX:13754597ENST00000360144-1617399_821679681.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369056-1617399_821768770.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369060-1516399_821651706.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chrX:13754597ENST00000369061-1415399_821655710.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chrX:13754597ENST00000457416-1718399_821768823.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243211chrX:13754596ENST00000359354-17378_3980255.0TransmembraneHelical
HgeneFGFR2chr10:123243212chrX:13754597ENST00000359354-17378_3980255.0TransmembraneHelical


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Fusion Gene Sequence for FGFR2-OFD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30291_30291_1_FGFR2-OFD1_FGFR2_chr10_123243211_ENST00000346997_OFD1_chrX_13754596_ENST00000380550_length(transcript)=5368nt_BP=2307nt
GGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGT
TTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAG
TCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTG
CTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAA
ACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAG
AACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAG
TTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGC
TACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAA
TACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCC
TCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAG
AACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACGGACAAAGAGATTGAGGTT
CTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATATACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGG
TTGACAGTTCTGCCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTC
TTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCAC
AAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACA
ACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGA
GATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCC
AAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATG
AAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCT
AAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATG
ACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCA
GCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAA
AAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCC
TTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAA
GGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCA
ACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGACACAACTTCGAAACCAGCTAATTCATGAGTTG
ATGCACCCTGTATTGAGTGGAGAACTGCAGCCTCGGTCCATTTCAGTAGAAGGGAGCTCCCTCTTAATAGGCGCCTCTAACTCTTTAGTG
GCAGATCACTTACAAAGATGTGGCTATGAATATTCACTTTCTGTTTTCTTTCCAGAAAGTGGTTTGGCAAAAGAAAAGGTATTTACTATG
CAGGATCTATTACAACTCATTAAAATCAACCCTACTTCCAGTCTCTACAAATCACTGGTTTCAGGATCTGATAAAGAAAATCAAAAAGGT
TTTCTTATGCATTTTTTAAAAGAATTGGCAGAATATCATCAAGCTAAAGAGAGTTGTAATATGGAAACTCAGACAAGTTCGACATTTAAC
AGAGATTCTCTGGCTGAGAAGCTTCAGCTTATTGATGATCAGTTTGCAGATGCTTACCCTCAGCGTATCAAGTTCGAATCTTTAGAAATA
AAGCTAAATGAGTATAAGAGAGAAATAGAAGAGCAACTTCGGGCAGAAATGTGTCAAAAGTTGAAGTTTTTTAAAGATACCGAGATAGCA
AAAATTAAAATGGAAGCAAAAAAAAAGTATGAAAAGGAGTTAACCATGTTCCAGAATGATTTTGAAAAAGCTTGTCAAGCAAAATCTGAA
GCTCTCGTTCTTCGGGAAAAGAGTACCCTTGAAAGAATTCACAAGCACCAAGAGATTGAAACAAAAGAAATTTATGCTCAAAGGCAACTT
TTACTAAAAGATATGGATTTGCTAAGAGGAAGAGAAGCAGAGCTGAAGCAAAGAGTTGAAGCTTTTGAATTGTATCAACTTGAACTGAAG
GATGACTACATCATTAGAACTAATCGACTGATTGAAGATGAAAGGAAGAATAAAGAAAAAGCTGTTCATTTGCAAGAGGAGCTCATAGCT
ATTAATTCAAAAAAGGAGGAACTCAATCAATCTGTAAATCGTGTGAAAGAACTTGAGCTTGAATTAGAGTCTGTCAAAGCCCAGTCTTTG
GCAATAACAAAACAAAACCATATGCTGAATGAAAAGGTTAAAGAGATGAGTGATTATTCACTACTAAAAGAAGAGAAACTGGAGCTTCTG
GCACAAAATAAATTACTTAAACAACAACTGGAAGAGAGTAGAAATGAAAACCTGCGTCTCCTAAACCGCCTAGCTCAGCCGGCTCCTGAA
CTTGCAGTCTTTCAGAAAGAACTACGGAAAGCCGAAAAGGCTATAGTGGTTGAGCATGAGGAGTTCGAAAGCTGCAGGCAAGCTCTGCAC
AAACAACTGCAAGACGAAATTGAGCATTCTGCACAGCTGAAGGCCCAGATTCTAGGTTACAAAGCTTCTGTAAAGAGTTTAACTACTCAG
GTTGCCGATTTAAAATTGCAACTGAAGCAAACTCAGACAGCCCTAGAGAATGAAGTGTACTGCAATCCAAAGCAGTCTGTGATCGATCGT
TCTGTCAATGGATTAATAAATGGCAATGTGGTGCCTTGCAATGGTGAGATAAGTGGGGATTTCTTGAACAATCCTTTTAAACAGGAAAAC
GTTCTAGCACGTATGGTTGCATCAAGGATCACAAATTATCCAACTGCATGGGTGGAGGGTAGTTCCCCTGATTCTGACCTTGAGTTTGTA
GCCAATACTAAGGCAAGGGTCAAAGAGCTTCAGCAAGAGGCCGAACGCTTGGAAAAGGCTTTCAGAAGTTACCATCGGAGAGTCATTAAA
AACTCTGCCAAAAGCCCACTAGCAGCAAAGAGCCCACCATCTCTGCACTTGCTGGAAGCCTTCAAAAACATTACTTCCAGTTCCCCGGAA
AGACATATTTTTGGAGAGGACAGAGTTGTCTCTGAGCAGCCTCAAGTGGGCACACTTGAAGAAAGGAATGACGTCGTGGAAGCACTGACA
GGCAGTGCAGCCTCGAGGCTCCGCGGGGGCACTTCCTCCAGACGCCTCTCTTCCACACCCCTTCCAAAAGCAAAAAGAAGCCTCGAAAGT
GAAATGTATCTGGAAGGTCTGGGCAGATCACACATTGCTTCCCCCAGTCCTTGTCCTGACAGAATGCCCCTACCATCACCCACTGAGTCT
AGGCACAGCCTCTCCATCCCTCCTGTCTCCAGCCCTCCGGAGCAGAAAGTGGGTCTTTATCGAAGACAAACTGAACTTCAAGACAAAAGT
GAATTTTCAGATGTGGACAAGCTAGCTTTTAAGGATAATGAGGAGTTTGAATCATCTTTTGAATCTGCAGGGAACATGCCAAGGCAGTTG
GAAATGGGCGGGCTTTCTCCTGCCGGGGATATGTCTCATGTGGACGCTGCTGCAGCTGCTGTGCCCCTCTCATATCAGCACCCAAGTGTA
GATCAGAAACAAATTGAAGAACAAAAGGAAGAAGAAAAAATACGGGAACAGCAAGTGAAAGAACGAAGGCAGAGAGAAGAAAGAAGGCAG
AGTAACCTACAAGAAGTTTTAGAAAGGGAACGAAGAGAACTAGAAAAACTGTATCAGGAAAGGAAGATGATTGAAGAATCACTGAAGATT
AAAATAAAAAAGGAATTAGAAATGGAAAATGAATTAGAAATGAGTAATCAAGAAATAAAAGACAAATCTGCTCACAGTGAAAATCCTTTA
GAGAAATACATGAAAATCATCCAGCAGGAGCAAGACCAGGAGTCGGCAGATAAGAGCTCAAAAAAGATGGTCCAAGAAGGCTCCCTAGTG
GACACGCTGCAATCTAGTGACAAAGTCGAAAGTTTAACAGGCTTTTCTCATGAAGAACTAGACGACTCTTGGTAACCATGTTTGCTGCCC
AGCTTCTAACTTACATACCGTGAGAAGTTACGTAACATTTACTCCTTTGTAAATGTTTCCCTATCATCAGACAAAACTCAATAAAAATGT
GTGTAATCCAATGTGGGTTTTTTTTTCCATAATTAATTTTGATACCATAGTGTGTGAACCAAGAATAATCTAGTCACGTGAAACCTCTTC
TCCAGTCATAGTATTTCTCATTCATTATAATAAAAGTAACTGGCTTTTAACCTCCTTA

>30291_30291_1_FGFR2-OFD1_FGFR2_chr10_123243211_ENST00000346997_OFD1_chrX_13754596_ENST00000380550_length(amino acids)=1700AA_BP=765
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLS
STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV
LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM
DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNETQLRNQLIHELMHPVLSGELQPRSISVEGSSLLIGASNSLVADHL
QRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSL
AEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVL
REKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSK
KEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVF
QKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNG
LINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAK
SPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYL
EGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGG
LSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKK
ELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDSW

--------------------------------------------------------------
>30291_30291_2_FGFR2-OFD1_FGFR2_chr10_123243211_ENST00000346997_OFD1_chrX_13754596_ENST00000398395_length(transcript)=3453nt_BP=2307nt
GGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGT
TTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAG
TCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTG
CTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAA
ACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAG
AACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAG
TTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGC
TACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAA
TACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCC
TCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAG
AACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACGGACAAAGAGATTGAGGTT
CTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATATACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGG
TTGACAGTTCTGCCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTC
TTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCAC
AAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACA
ACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGA
GATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCC
AAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATG
AAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCT
AAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATG
ACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCA
GCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAA
AAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCC
TTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAA
GGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCA
ACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGACACAACTTCGAAACCAGCTAATTCATGAGTTG
ATGCACCCTGTATTGAGTGGAGAACTGCAGCCTCGGTCCATTTCAGTAGAAGGGAGCTCCCTCTTAATAGGCGCCTCTAACTCTTTAGTG
GCAGATCACTTACAAAGATGTGGCTATGAATATTCACTTTCTGTTTTCTTTCCAGAAAGTGGTTTGGCAAAAGAAAAGGTATTTACTATG
CAGGATCTATTACAACTCATTAAAATCAACCCTACTTCCAGTCTCTACAAATCACTGGTTTCAGGATCTGATAAAGAAAATCAAAAAGGT
TTTCTTATGCATTTTTTAAAAGAATTGGCAGAATATCATCAAGCTAAAGAGAGTTGTAATATGGAAACTCAGACAAGTTCGACATTTAAC
AGAGATTCTCTGGCTGAGAAGCTTCAGCTTATTGATGATCAGTTTGCAGATGCTTACCCTCAGCGTATCAAGTTCGAATCTTTAGAAATA
AAGCTAAATGAGTATAAGAGAGAAATAGAAGAGCAACTTCGGGCAGAAATGTGTCAAAAGTTGAAGTTTTTTAAAGATACCGAGATAGCA
AAAATTAAAATGGAAGCAAAAAAAAAGTATGAAAAGGAGTTAACCATGTTCCAGAATGATTTTGAAAAAGCTTGTCAAGCAAAATCTGAA
GCTCTCGTTCTTCGGGAAAAGAGTACCCTTGAAAGAATTCACAAGCACCAAGAGATTGAAACAAAAGAAATTTATGCTCAAAGGCAACTT
TTACTAAAAGATATGGATTTGCTAAGAGGAAGAGAAGCAGAGCTGAAGCAAAGAGTTGAAGCTTTTGAATTGAACCAGAAGCTCCAGGAA
GAAAAACATAAAAGCATAACTGAGGCACTTAGGAGACAGGAGCAGAATATAAAGAGTTTTGAGGAGACCTATGACCGAAAGCTCAAGAAT
GAACTTCTAAACTTCCACAGGCTGCATGGTGTCTGCCTGGCTTTGGGAATCCTCATATGACTTTGGCAGGTGTTGGAGTTTGGAGGCTCT
TCGCCACAGGAGTGCTTCTATTTCCTTTTGGAACCAAAAGGGCAGCTGGTAACAGCTGGGAAAGGGAAGTGAAACTGTGAAAATGTGCCT
TTTGGTATTGCTAATCCGGATATAATGCTCTTG

>30291_30291_2_FGFR2-OFD1_FGFR2_chr10_123243211_ENST00000346997_OFD1_chrX_13754596_ENST00000398395_length(amino acids)=1095AA_BP=765
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLS
STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV
LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM
DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNETQLRNQLIHELMHPVLSGELQPRSISVEGSSLLIGASNSLVADHL
QRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSL
AEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVL
REKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLN
FHRLHGVCLALGILI

--------------------------------------------------------------
>30291_30291_3_FGFR2-OFD1_FGFR2_chr10_123243211_ENST00000369056_OFD1_chrX_13754596_ENST00000380550_length(transcript)=5389nt_BP=2328nt
GGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGG
CCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCT
GCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAAC
AATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACT
GTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGAT
TTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCC
AACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCAT
CGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTA
GTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTG
CCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAG
CACGTGGAAAAGAACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGCACTCGGGGATAAATAGTTCCAATGCA
GAAGTGCTGGCTCTGTTCAATGTGACCGAGGCGGATGCTGGGGAATATATATGTAAGGTCTCCAATTATATAGGGCAGGCCAACCAGTCT
GCCTGGCTCACTGTCCTGCCAAAACAGCAAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTAC
TGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGC
CAGCCGGCTGTGCACAAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAAC
ACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGAC
CCAAAATGGGAGTTTCCAAGAGATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTG
GGAATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTG
GTGTCAGAGATGGAGATGATGAAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTAT
GTCATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAAC
CGTGTTCCTGAGGAGCAGATGACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAA
TGTATTCATCGAGATTTAGCAGCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATC
AACAATATAGACTATTACAAAAAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACT
CATCAGAGTGATGTCTGGTCCTTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAA
CTTTTTAAGCTGCTGAAGGAAGGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCAT
GCAGTGCCCTCCCAGAGACCAACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGACACAACTTCGA
AACCAGCTAATTCATGAGTTGATGCACCCTGTATTGAGTGGAGAACTGCAGCCTCGGTCCATTTCAGTAGAAGGGAGCTCCCTCTTAATA
GGCGCCTCTAACTCTTTAGTGGCAGATCACTTACAAAGATGTGGCTATGAATATTCACTTTCTGTTTTCTTTCCAGAAAGTGGTTTGGCA
AAAGAAAAGGTATTTACTATGCAGGATCTATTACAACTCATTAAAATCAACCCTACTTCCAGTCTCTACAAATCACTGGTTTCAGGATCT
GATAAAGAAAATCAAAAAGGTTTTCTTATGCATTTTTTAAAAGAATTGGCAGAATATCATCAAGCTAAAGAGAGTTGTAATATGGAAACT
CAGACAAGTTCGACATTTAACAGAGATTCTCTGGCTGAGAAGCTTCAGCTTATTGATGATCAGTTTGCAGATGCTTACCCTCAGCGTATC
AAGTTCGAATCTTTAGAAATAAAGCTAAATGAGTATAAGAGAGAAATAGAAGAGCAACTTCGGGCAGAAATGTGTCAAAAGTTGAAGTTT
TTTAAAGATACCGAGATAGCAAAAATTAAAATGGAAGCAAAAAAAAAGTATGAAAAGGAGTTAACCATGTTCCAGAATGATTTTGAAAAA
GCTTGTCAAGCAAAATCTGAAGCTCTCGTTCTTCGGGAAAAGAGTACCCTTGAAAGAATTCACAAGCACCAAGAGATTGAAACAAAAGAA
ATTTATGCTCAAAGGCAACTTTTACTAAAAGATATGGATTTGCTAAGAGGAAGAGAAGCAGAGCTGAAGCAAAGAGTTGAAGCTTTTGAA
TTGTATCAACTTGAACTGAAGGATGACTACATCATTAGAACTAATCGACTGATTGAAGATGAAAGGAAGAATAAAGAAAAAGCTGTTCAT
TTGCAAGAGGAGCTCATAGCTATTAATTCAAAAAAGGAGGAACTCAATCAATCTGTAAATCGTGTGAAAGAACTTGAGCTTGAATTAGAG
TCTGTCAAAGCCCAGTCTTTGGCAATAACAAAACAAAACCATATGCTGAATGAAAAGGTTAAAGAGATGAGTGATTATTCACTACTAAAA
GAAGAGAAACTGGAGCTTCTGGCACAAAATAAATTACTTAAACAACAACTGGAAGAGAGTAGAAATGAAAACCTGCGTCTCCTAAACCGC
CTAGCTCAGCCGGCTCCTGAACTTGCAGTCTTTCAGAAAGAACTACGGAAAGCCGAAAAGGCTATAGTGGTTGAGCATGAGGAGTTCGAA
AGCTGCAGGCAAGCTCTGCACAAACAACTGCAAGACGAAATTGAGCATTCTGCACAGCTGAAGGCCCAGATTCTAGGTTACAAAGCTTCT
GTAAAGAGTTTAACTACTCAGGTTGCCGATTTAAAATTGCAACTGAAGCAAACTCAGACAGCCCTAGAGAATGAAGTGTACTGCAATCCA
AAGCAGTCTGTGATCGATCGTTCTGTCAATGGATTAATAAATGGCAATGTGGTGCCTTGCAATGGTGAGATAAGTGGGGATTTCTTGAAC
AATCCTTTTAAACAGGAAAACGTTCTAGCACGTATGGTTGCATCAAGGATCACAAATTATCCAACTGCATGGGTGGAGGGTAGTTCCCCT
GATTCTGACCTTGAGTTTGTAGCCAATACTAAGGCAAGGGTCAAAGAGCTTCAGCAAGAGGCCGAACGCTTGGAAAAGGCTTTCAGAAGT
TACCATCGGAGAGTCATTAAAAACTCTGCCAAAAGCCCACTAGCAGCAAAGAGCCCACCATCTCTGCACTTGCTGGAAGCCTTCAAAAAC
ATTACTTCCAGTTCCCCGGAAAGACATATTTTTGGAGAGGACAGAGTTGTCTCTGAGCAGCCTCAAGTGGGCACACTTGAAGAAAGGAAT
GACGTCGTGGAAGCACTGACAGGCAGTGCAGCCTCGAGGCTCCGCGGGGGCACTTCCTCCAGACGCCTCTCTTCCACACCCCTTCCAAAA
GCAAAAAGAAGCCTCGAAAGTGAAATGTATCTGGAAGGTCTGGGCAGATCACACATTGCTTCCCCCAGTCCTTGTCCTGACAGAATGCCC
CTACCATCACCCACTGAGTCTAGGCACAGCCTCTCCATCCCTCCTGTCTCCAGCCCTCCGGAGCAGAAAGTGGGTCTTTATCGAAGACAA
ACTGAACTTCAAGACAAAAGTGAATTTTCAGATGTGGACAAGCTAGCTTTTAAGGATAATGAGGAGTTTGAATCATCTTTTGAATCTGCA
GGGAACATGCCAAGGCAGTTGGAAATGGGCGGGCTTTCTCCTGCCGGGGATATGTCTCATGTGGACGCTGCTGCAGCTGCTGTGCCCCTC
TCATATCAGCACCCAAGTGTAGATCAGAAACAAATTGAAGAACAAAAGGAAGAAGAAAAAATACGGGAACAGCAAGTGAAAGAACGAAGG
CAGAGAGAAGAAAGAAGGCAGAGTAACCTACAAGAAGTTTTAGAAAGGGAACGAAGAGAACTAGAAAAACTGTATCAGGAAAGGAAGATG
ATTGAAGAATCACTGAAGATTAAAATAAAAAAGGAATTAGAAATGGAAAATGAATTAGAAATGAGTAATCAAGAAATAAAAGACAAATCT
GCTCACAGTGAAAATCCTTTAGAGAAATACATGAAAATCATCCAGCAGGAGCAAGACCAGGAGTCGGCAGATAAGAGCTCAAAAAAGATG
GTCCAAGAAGGCTCCCTAGTGGACACGCTGCAATCTAGTGACAAAGTCGAAAGTTTAACAGGCTTTTCTCATGAAGAACTAGACGACTCT
TGGTAACCATGTTTGCTGCCCAGCTTCTAACTTACATACCGTGAGAAGTTACGTAACATTTACTCCTTTGTAAATGTTTCCCTATCATCA
GACAAAACTCAATAAAAATGTGTGTAATCCAATGTGGGTTTTTTTTTCCATAATTAATTTTGATACCATAGTGTGTGAACCAAGAATAAT
CTAGTCACGTGAAACCTCTTCTCCAGTCATAGTATTTCTCATTCATTATAATAAAAGTAACTGGCTTTTAACCTCCTTA

>30291_30291_3_FGFR2-OFD1_FGFR2_chr10_123243211_ENST00000369056_OFD1_chrX_13754596_ENST00000380550_length(amino acids)=1703AA_BP=768
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK
QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG
HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNETQLRNQLIHELMHPVLSGELQPRSISVEGSSLLIGASNSLVA
DHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNR
DSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEA
LVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAI
NSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPEL
AVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRS
VNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKN
SAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESE
MYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLE
MGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIK
IKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDSW

--------------------------------------------------------------
>30291_30291_4_FGFR2-OFD1_FGFR2_chr10_123243211_ENST00000369056_OFD1_chrX_13754596_ENST00000398395_length(transcript)=3474nt_BP=2328nt
GGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGG
CCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCT
GCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAAC
AATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACT
GTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGAT
TTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCC
AACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCAT
CGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTA
GTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTG
CCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAG
CACGTGGAAAAGAACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGCACTCGGGGATAAATAGTTCCAATGCA
GAAGTGCTGGCTCTGTTCAATGTGACCGAGGCGGATGCTGGGGAATATATATGTAAGGTCTCCAATTATATAGGGCAGGCCAACCAGTCT
GCCTGGCTCACTGTCCTGCCAAAACAGCAAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTAC
TGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGC
CAGCCGGCTGTGCACAAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAAC
ACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGAC
CCAAAATGGGAGTTTCCAAGAGATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTG
GGAATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTG
GTGTCAGAGATGGAGATGATGAAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTAT
GTCATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAAC
CGTGTTCCTGAGGAGCAGATGACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAA
TGTATTCATCGAGATTTAGCAGCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATC
AACAATATAGACTATTACAAAAAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACT
CATCAGAGTGATGTCTGGTCCTTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAA
CTTTTTAAGCTGCTGAAGGAAGGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCAT
GCAGTGCCCTCCCAGAGACCAACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGACACAACTTCGA
AACCAGCTAATTCATGAGTTGATGCACCCTGTATTGAGTGGAGAACTGCAGCCTCGGTCCATTTCAGTAGAAGGGAGCTCCCTCTTAATA
GGCGCCTCTAACTCTTTAGTGGCAGATCACTTACAAAGATGTGGCTATGAATATTCACTTTCTGTTTTCTTTCCAGAAAGTGGTTTGGCA
AAAGAAAAGGTATTTACTATGCAGGATCTATTACAACTCATTAAAATCAACCCTACTTCCAGTCTCTACAAATCACTGGTTTCAGGATCT
GATAAAGAAAATCAAAAAGGTTTTCTTATGCATTTTTTAAAAGAATTGGCAGAATATCATCAAGCTAAAGAGAGTTGTAATATGGAAACT
CAGACAAGTTCGACATTTAACAGAGATTCTCTGGCTGAGAAGCTTCAGCTTATTGATGATCAGTTTGCAGATGCTTACCCTCAGCGTATC
AAGTTCGAATCTTTAGAAATAAAGCTAAATGAGTATAAGAGAGAAATAGAAGAGCAACTTCGGGCAGAAATGTGTCAAAAGTTGAAGTTT
TTTAAAGATACCGAGATAGCAAAAATTAAAATGGAAGCAAAAAAAAAGTATGAAAAGGAGTTAACCATGTTCCAGAATGATTTTGAAAAA
GCTTGTCAAGCAAAATCTGAAGCTCTCGTTCTTCGGGAAAAGAGTACCCTTGAAAGAATTCACAAGCACCAAGAGATTGAAACAAAAGAA
ATTTATGCTCAAAGGCAACTTTTACTAAAAGATATGGATTTGCTAAGAGGAAGAGAAGCAGAGCTGAAGCAAAGAGTTGAAGCTTTTGAA
TTGAACCAGAAGCTCCAGGAAGAAAAACATAAAAGCATAACTGAGGCACTTAGGAGACAGGAGCAGAATATAAAGAGTTTTGAGGAGACC
TATGACCGAAAGCTCAAGAATGAACTTCTAAACTTCCACAGGCTGCATGGTGTCTGCCTGGCTTTGGGAATCCTCATATGACTTTGGCAG
GTGTTGGAGTTTGGAGGCTCTTCGCCACAGGAGTGCTTCTATTTCCTTTTGGAACCAAAAGGGCAGCTGGTAACAGCTGGGAAAGGGAAG
TGAAACTGTGAAAATGTGCCTTTTGGTATTGCTAATCCGGATATAATGCTCTTG

>30291_30291_4_FGFR2-OFD1_FGFR2_chr10_123243211_ENST00000369056_OFD1_chrX_13754596_ENST00000398395_length(amino acids)=1098AA_BP=768
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK
QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG
HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNETQLRNQLIHELMHPVLSGELQPRSISVEGSSLLIGASNSLVA
DHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNR
DSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEA
LVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNE
LLNFHRLHGVCLALGILI

--------------------------------------------------------------
>30291_30291_5_FGFR2-OFD1_FGFR2_chr10_123243211_ENST00000369061_OFD1_chrX_13754596_ENST00000380550_length(transcript)=5176nt_BP=2115nt
TGACTGCAGCAGCAGCGGCAGCGCCTCGGTTCCTGAGCCCACCGCAGGCTGAAGGCATTGCGCGTAGTCCATGCCCGTAGAGGAAGTGTG
CAGATGGGATTAACGTCCACATGGAGATATGGAAGAGGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTG
GTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACC
AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATC
AGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA
GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCC
GGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAA
AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGG
TGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT
GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGCG
CCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTG
GTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAACGTATC
CCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACACGCCTCTCT
TCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAGCTGACA
CTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTC
ACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATGATTGGG
AAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTC
CGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTCAAGGAC
TTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCAGCCAGAAATGTT
TTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAAAAGACCACCAAT
GGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCCTTCGGGGTGTTA
ATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAAGGACACAGAATG
GATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCAACGTTCAAGCAG
TTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGACACAACTTCGAAACCAGCTAATTCATGAGTTGATGCACCCTGTA
TTGAGTGGAGAACTGCAGCCTCGGTCCATTTCAGTAGAAGGGAGCTCCCTCTTAATAGGCGCCTCTAACTCTTTAGTGGCAGATCACTTA
CAAAGATGTGGCTATGAATATTCACTTTCTGTTTTCTTTCCAGAAAGTGGTTTGGCAAAAGAAAAGGTATTTACTATGCAGGATCTATTA
CAACTCATTAAAATCAACCCTACTTCCAGTCTCTACAAATCACTGGTTTCAGGATCTGATAAAGAAAATCAAAAAGGTTTTCTTATGCAT
TTTTTAAAAGAATTGGCAGAATATCATCAAGCTAAAGAGAGTTGTAATATGGAAACTCAGACAAGTTCGACATTTAACAGAGATTCTCTG
GCTGAGAAGCTTCAGCTTATTGATGATCAGTTTGCAGATGCTTACCCTCAGCGTATCAAGTTCGAATCTTTAGAAATAAAGCTAAATGAG
TATAAGAGAGAAATAGAAGAGCAACTTCGGGCAGAAATGTGTCAAAAGTTGAAGTTTTTTAAAGATACCGAGATAGCAAAAATTAAAATG
GAAGCAAAAAAAAAGTATGAAAAGGAGTTAACCATGTTCCAGAATGATTTTGAAAAAGCTTGTCAAGCAAAATCTGAAGCTCTCGTTCTT
CGGGAAAAGAGTACCCTTGAAAGAATTCACAAGCACCAAGAGATTGAAACAAAAGAAATTTATGCTCAAAGGCAACTTTTACTAAAAGAT
ATGGATTTGCTAAGAGGAAGAGAAGCAGAGCTGAAGCAAAGAGTTGAAGCTTTTGAATTGTATCAACTTGAACTGAAGGATGACTACATC
ATTAGAACTAATCGACTGATTGAAGATGAAAGGAAGAATAAAGAAAAAGCTGTTCATTTGCAAGAGGAGCTCATAGCTATTAATTCAAAA
AAGGAGGAACTCAATCAATCTGTAAATCGTGTGAAAGAACTTGAGCTTGAATTAGAGTCTGTCAAAGCCCAGTCTTTGGCAATAACAAAA
CAAAACCATATGCTGAATGAAAAGGTTAAAGAGATGAGTGATTATTCACTACTAAAAGAAGAGAAACTGGAGCTTCTGGCACAAAATAAA
TTACTTAAACAACAACTGGAAGAGAGTAGAAATGAAAACCTGCGTCTCCTAAACCGCCTAGCTCAGCCGGCTCCTGAACTTGCAGTCTTT
CAGAAAGAACTACGGAAAGCCGAAAAGGCTATAGTGGTTGAGCATGAGGAGTTCGAAAGCTGCAGGCAAGCTCTGCACAAACAACTGCAA
GACGAAATTGAGCATTCTGCACAGCTGAAGGCCCAGATTCTAGGTTACAAAGCTTCTGTAAAGAGTTTAACTACTCAGGTTGCCGATTTA
AAATTGCAACTGAAGCAAACTCAGACAGCCCTAGAGAATGAAGTGTACTGCAATCCAAAGCAGTCTGTGATCGATCGTTCTGTCAATGGA
TTAATAAATGGCAATGTGGTGCCTTGCAATGGTGAGATAAGTGGGGATTTCTTGAACAATCCTTTTAAACAGGAAAACGTTCTAGCACGT
ATGGTTGCATCAAGGATCACAAATTATCCAACTGCATGGGTGGAGGGTAGTTCCCCTGATTCTGACCTTGAGTTTGTAGCCAATACTAAG
GCAAGGGTCAAAGAGCTTCAGCAAGAGGCCGAACGCTTGGAAAAGGCTTTCAGAAGTTACCATCGGAGAGTCATTAAAAACTCTGCCAAA
AGCCCACTAGCAGCAAAGAGCCCACCATCTCTGCACTTGCTGGAAGCCTTCAAAAACATTACTTCCAGTTCCCCGGAAAGACATATTTTT
GGAGAGGACAGAGTTGTCTCTGAGCAGCCTCAAGTGGGCACACTTGAAGAAAGGAATGACGTCGTGGAAGCACTGACAGGCAGTGCAGCC
TCGAGGCTCCGCGGGGGCACTTCCTCCAGACGCCTCTCTTCCACACCCCTTCCAAAAGCAAAAAGAAGCCTCGAAAGTGAAATGTATCTG
GAAGGTCTGGGCAGATCACACATTGCTTCCCCCAGTCCTTGTCCTGACAGAATGCCCCTACCATCACCCACTGAGTCTAGGCACAGCCTC
TCCATCCCTCCTGTCTCCAGCCCTCCGGAGCAGAAAGTGGGTCTTTATCGAAGACAAACTGAACTTCAAGACAAAAGTGAATTTTCAGAT
GTGGACAAGCTAGCTTTTAAGGATAATGAGGAGTTTGAATCATCTTTTGAATCTGCAGGGAACATGCCAAGGCAGTTGGAAATGGGCGGG
CTTTCTCCTGCCGGGGATATGTCTCATGTGGACGCTGCTGCAGCTGCTGTGCCCCTCTCATATCAGCACCCAAGTGTAGATCAGAAACAA
ATTGAAGAACAAAAGGAAGAAGAAAAAATACGGGAACAGCAAGTGAAAGAACGAAGGCAGAGAGAAGAAAGAAGGCAGAGTAACCTACAA
GAAGTTTTAGAAAGGGAACGAAGAGAACTAGAAAAACTGTATCAGGAAAGGAAGATGATTGAAGAATCACTGAAGATTAAAATAAAAAAG
GAATTAGAAATGGAAAATGAATTAGAAATGAGTAATCAAGAAATAAAAGACAAATCTGCTCACAGTGAAAATCCTTTAGAGAAATACATG
AAAATCATCCAGCAGGAGCAAGACCAGGAGTCGGCAGATAAGAGCTCAAAAAAGATGGTCCAAGAAGGCTCCCTAGTGGACACGCTGCAA
TCTAGTGACAAAGTCGAAAGTTTAACAGGCTTTTCTCATGAAGAACTAGACGACTCTTGGTAACCATGTTTGCTGCCCAGCTTCTAACTT
ACATACCGTGAGAAGTTACGTAACATTTACTCCTTTGTAAATGTTTCCCTATCATCAGACAAAACTCAATAAAAATGTGTGTAATCCAAT
GTGGGTTTTTTTTTCCATAATTAATTTTGATACCATAGTGTGTGAACCAAGAATAATCTAGTCACGTGAAACCTCTTCTCCAGTCATAGT
ATTTCTCATTCATTATAATAAAAGTAACTGGCTTTTAACCTCCTTA

>30291_30291_5_FGFR2-OFD1_FGFR2_chr10_123243211_ENST00000369061_OFD1_chrX_13754596_ENST00000380550_length(amino acids)=1624AA_BP=689
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNETQLRNQLIHELMHPVLSGELQPRSISVEGSS
LLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCN
METQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQND
FEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELYQLELKDDYIIRTNRLIEDERKNKEK
AVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRL
LNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVY
CNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKA
FRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTP
LPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSF
ESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQE
RKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEEL
DDSW

--------------------------------------------------------------
>30291_30291_6_FGFR2-OFD1_FGFR2_chr10_123243211_ENST00000369061_OFD1_chrX_13754596_ENST00000398395_length(transcript)=3261nt_BP=2115nt
TGACTGCAGCAGCAGCGGCAGCGCCTCGGTTCCTGAGCCCACCGCAGGCTGAAGGCATTGCGCGTAGTCCATGCCCGTAGAGGAAGTGTG
CAGATGGGATTAACGTCCACATGGAGATATGGAAGAGGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTG
GTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACC
AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATC
AGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA
GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCC
GGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAA
AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGG
TGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT
GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGCG
CCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTG
GTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAACGTATC
CCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACACGCCTCTCT
TCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAGCTGACA
CTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTC
ACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATGATTGGG
AAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTC
CGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTCAAGGAC
TTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCAGCCAGAAATGTT
TTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAAAAGACCACCAAT
GGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCCTTCGGGGTGTTA
ATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAAGGACACAGAATG
GATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCAACGTTCAAGCAG
TTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGACACAACTTCGAAACCAGCTAATTCATGAGTTGATGCACCCTGTA
TTGAGTGGAGAACTGCAGCCTCGGTCCATTTCAGTAGAAGGGAGCTCCCTCTTAATAGGCGCCTCTAACTCTTTAGTGGCAGATCACTTA
CAAAGATGTGGCTATGAATATTCACTTTCTGTTTTCTTTCCAGAAAGTGGTTTGGCAAAAGAAAAGGTATTTACTATGCAGGATCTATTA
CAACTCATTAAAATCAACCCTACTTCCAGTCTCTACAAATCACTGGTTTCAGGATCTGATAAAGAAAATCAAAAAGGTTTTCTTATGCAT
TTTTTAAAAGAATTGGCAGAATATCATCAAGCTAAAGAGAGTTGTAATATGGAAACTCAGACAAGTTCGACATTTAACAGAGATTCTCTG
GCTGAGAAGCTTCAGCTTATTGATGATCAGTTTGCAGATGCTTACCCTCAGCGTATCAAGTTCGAATCTTTAGAAATAAAGCTAAATGAG
TATAAGAGAGAAATAGAAGAGCAACTTCGGGCAGAAATGTGTCAAAAGTTGAAGTTTTTTAAAGATACCGAGATAGCAAAAATTAAAATG
GAAGCAAAAAAAAAGTATGAAAAGGAGTTAACCATGTTCCAGAATGATTTTGAAAAAGCTTGTCAAGCAAAATCTGAAGCTCTCGTTCTT
CGGGAAAAGAGTACCCTTGAAAGAATTCACAAGCACCAAGAGATTGAAACAAAAGAAATTTATGCTCAAAGGCAACTTTTACTAAAAGAT
ATGGATTTGCTAAGAGGAAGAGAAGCAGAGCTGAAGCAAAGAGTTGAAGCTTTTGAATTGAACCAGAAGCTCCAGGAAGAAAAACATAAA
AGCATAACTGAGGCACTTAGGAGACAGGAGCAGAATATAAAGAGTTTTGAGGAGACCTATGACCGAAAGCTCAAGAATGAACTTCTAAAC
TTCCACAGGCTGCATGGTGTCTGCCTGGCTTTGGGAATCCTCATATGACTTTGGCAGGTGTTGGAGTTTGGAGGCTCTTCGCCACAGGAG
TGCTTCTATTTCCTTTTGGAACCAAAAGGGCAGCTGGTAACAGCTGGGAAAGGGAAGTGAAACTGTGAAAATGTGCCTTTTGGTATTGCT
AATCCGGATATAATGCTCTTG

>30291_30291_6_FGFR2-OFD1_FGFR2_chr10_123243211_ENST00000369061_OFD1_chrX_13754596_ENST00000398395_length(amino acids)=1019AA_BP=689
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNETQLRNQLIHELMHPVLSGELQPRSISVEGSS
LLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCN
METQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQND
FEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSF
EETYDRKLKNELLNFHRLHGVCLALGILI

--------------------------------------------------------------
>30291_30291_7_FGFR2-OFD1_FGFR2_chr10_123243212_ENST00000346997_OFD1_chrX_13754597_ENST00000380550_length(transcript)=5368nt_BP=2307nt
GGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGT
TTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAG
TCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTG
CTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAA
ACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAG
AACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAG
TTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGC
TACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAA
TACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCC
TCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAG
AACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACGGACAAAGAGATTGAGGTT
CTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATATACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGG
TTGACAGTTCTGCCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTC
TTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCAC
AAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACA
ACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGA
GATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCC
AAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATG
AAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCT
AAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATG
ACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCA
GCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAA
AAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCC
TTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAA
GGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCA
ACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGACACAACTTCGAAACCAGCTAATTCATGAGTTG
ATGCACCCTGTATTGAGTGGAGAACTGCAGCCTCGGTCCATTTCAGTAGAAGGGAGCTCCCTCTTAATAGGCGCCTCTAACTCTTTAGTG
GCAGATCACTTACAAAGATGTGGCTATGAATATTCACTTTCTGTTTTCTTTCCAGAAAGTGGTTTGGCAAAAGAAAAGGTATTTACTATG
CAGGATCTATTACAACTCATTAAAATCAACCCTACTTCCAGTCTCTACAAATCACTGGTTTCAGGATCTGATAAAGAAAATCAAAAAGGT
TTTCTTATGCATTTTTTAAAAGAATTGGCAGAATATCATCAAGCTAAAGAGAGTTGTAATATGGAAACTCAGACAAGTTCGACATTTAAC
AGAGATTCTCTGGCTGAGAAGCTTCAGCTTATTGATGATCAGTTTGCAGATGCTTACCCTCAGCGTATCAAGTTCGAATCTTTAGAAATA
AAGCTAAATGAGTATAAGAGAGAAATAGAAGAGCAACTTCGGGCAGAAATGTGTCAAAAGTTGAAGTTTTTTAAAGATACCGAGATAGCA
AAAATTAAAATGGAAGCAAAAAAAAAGTATGAAAAGGAGTTAACCATGTTCCAGAATGATTTTGAAAAAGCTTGTCAAGCAAAATCTGAA
GCTCTCGTTCTTCGGGAAAAGAGTACCCTTGAAAGAATTCACAAGCACCAAGAGATTGAAACAAAAGAAATTTATGCTCAAAGGCAACTT
TTACTAAAAGATATGGATTTGCTAAGAGGAAGAGAAGCAGAGCTGAAGCAAAGAGTTGAAGCTTTTGAATTGTATCAACTTGAACTGAAG
GATGACTACATCATTAGAACTAATCGACTGATTGAAGATGAAAGGAAGAATAAAGAAAAAGCTGTTCATTTGCAAGAGGAGCTCATAGCT
ATTAATTCAAAAAAGGAGGAACTCAATCAATCTGTAAATCGTGTGAAAGAACTTGAGCTTGAATTAGAGTCTGTCAAAGCCCAGTCTTTG
GCAATAACAAAACAAAACCATATGCTGAATGAAAAGGTTAAAGAGATGAGTGATTATTCACTACTAAAAGAAGAGAAACTGGAGCTTCTG
GCACAAAATAAATTACTTAAACAACAACTGGAAGAGAGTAGAAATGAAAACCTGCGTCTCCTAAACCGCCTAGCTCAGCCGGCTCCTGAA
CTTGCAGTCTTTCAGAAAGAACTACGGAAAGCCGAAAAGGCTATAGTGGTTGAGCATGAGGAGTTCGAAAGCTGCAGGCAAGCTCTGCAC
AAACAACTGCAAGACGAAATTGAGCATTCTGCACAGCTGAAGGCCCAGATTCTAGGTTACAAAGCTTCTGTAAAGAGTTTAACTACTCAG
GTTGCCGATTTAAAATTGCAACTGAAGCAAACTCAGACAGCCCTAGAGAATGAAGTGTACTGCAATCCAAAGCAGTCTGTGATCGATCGT
TCTGTCAATGGATTAATAAATGGCAATGTGGTGCCTTGCAATGGTGAGATAAGTGGGGATTTCTTGAACAATCCTTTTAAACAGGAAAAC
GTTCTAGCACGTATGGTTGCATCAAGGATCACAAATTATCCAACTGCATGGGTGGAGGGTAGTTCCCCTGATTCTGACCTTGAGTTTGTA
GCCAATACTAAGGCAAGGGTCAAAGAGCTTCAGCAAGAGGCCGAACGCTTGGAAAAGGCTTTCAGAAGTTACCATCGGAGAGTCATTAAA
AACTCTGCCAAAAGCCCACTAGCAGCAAAGAGCCCACCATCTCTGCACTTGCTGGAAGCCTTCAAAAACATTACTTCCAGTTCCCCGGAA
AGACATATTTTTGGAGAGGACAGAGTTGTCTCTGAGCAGCCTCAAGTGGGCACACTTGAAGAAAGGAATGACGTCGTGGAAGCACTGACA
GGCAGTGCAGCCTCGAGGCTCCGCGGGGGCACTTCCTCCAGACGCCTCTCTTCCACACCCCTTCCAAAAGCAAAAAGAAGCCTCGAAAGT
GAAATGTATCTGGAAGGTCTGGGCAGATCACACATTGCTTCCCCCAGTCCTTGTCCTGACAGAATGCCCCTACCATCACCCACTGAGTCT
AGGCACAGCCTCTCCATCCCTCCTGTCTCCAGCCCTCCGGAGCAGAAAGTGGGTCTTTATCGAAGACAAACTGAACTTCAAGACAAAAGT
GAATTTTCAGATGTGGACAAGCTAGCTTTTAAGGATAATGAGGAGTTTGAATCATCTTTTGAATCTGCAGGGAACATGCCAAGGCAGTTG
GAAATGGGCGGGCTTTCTCCTGCCGGGGATATGTCTCATGTGGACGCTGCTGCAGCTGCTGTGCCCCTCTCATATCAGCACCCAAGTGTA
GATCAGAAACAAATTGAAGAACAAAAGGAAGAAGAAAAAATACGGGAACAGCAAGTGAAAGAACGAAGGCAGAGAGAAGAAAGAAGGCAG
AGTAACCTACAAGAAGTTTTAGAAAGGGAACGAAGAGAACTAGAAAAACTGTATCAGGAAAGGAAGATGATTGAAGAATCACTGAAGATT
AAAATAAAAAAGGAATTAGAAATGGAAAATGAATTAGAAATGAGTAATCAAGAAATAAAAGACAAATCTGCTCACAGTGAAAATCCTTTA
GAGAAATACATGAAAATCATCCAGCAGGAGCAAGACCAGGAGTCGGCAGATAAGAGCTCAAAAAAGATGGTCCAAGAAGGCTCCCTAGTG
GACACGCTGCAATCTAGTGACAAAGTCGAAAGTTTAACAGGCTTTTCTCATGAAGAACTAGACGACTCTTGGTAACCATGTTTGCTGCCC
AGCTTCTAACTTACATACCGTGAGAAGTTACGTAACATTTACTCCTTTGTAAATGTTTCCCTATCATCAGACAAAACTCAATAAAAATGT
GTGTAATCCAATGTGGGTTTTTTTTTCCATAATTAATTTTGATACCATAGTGTGTGAACCAAGAATAATCTAGTCACGTGAAACCTCTTC
TCCAGTCATAGTATTTCTCATTCATTATAATAAAAGTAACTGGCTTTTAACCTCCTTA

>30291_30291_7_FGFR2-OFD1_FGFR2_chr10_123243212_ENST00000346997_OFD1_chrX_13754597_ENST00000380550_length(amino acids)=1700AA_BP=765
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLS
STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV
LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM
DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNETQLRNQLIHELMHPVLSGELQPRSISVEGSSLLIGASNSLVADHL
QRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSL
AEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVL
REKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSK
KEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVF
QKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNG
LINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAK
SPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYL
EGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGG
LSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKK
ELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDSW

--------------------------------------------------------------
>30291_30291_8_FGFR2-OFD1_FGFR2_chr10_123243212_ENST00000346997_OFD1_chrX_13754597_ENST00000398395_length(transcript)=3453nt_BP=2307nt
GGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGT
TTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAG
TCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTG
CTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAA
ACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAG
AACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAG
TTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGC
TACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAA
TACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCC
TCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAG
AACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACGGACAAAGAGATTGAGGTT
CTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATATACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGG
TTGACAGTTCTGCCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTC
TTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCAC
AAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACA
ACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGA
GATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCC
AAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATG
AAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCT
AAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATG
ACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCA
GCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAA
AAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCC
TTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAA
GGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCA
ACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGACACAACTTCGAAACCAGCTAATTCATGAGTTG
ATGCACCCTGTATTGAGTGGAGAACTGCAGCCTCGGTCCATTTCAGTAGAAGGGAGCTCCCTCTTAATAGGCGCCTCTAACTCTTTAGTG
GCAGATCACTTACAAAGATGTGGCTATGAATATTCACTTTCTGTTTTCTTTCCAGAAAGTGGTTTGGCAAAAGAAAAGGTATTTACTATG
CAGGATCTATTACAACTCATTAAAATCAACCCTACTTCCAGTCTCTACAAATCACTGGTTTCAGGATCTGATAAAGAAAATCAAAAAGGT
TTTCTTATGCATTTTTTAAAAGAATTGGCAGAATATCATCAAGCTAAAGAGAGTTGTAATATGGAAACTCAGACAAGTTCGACATTTAAC
AGAGATTCTCTGGCTGAGAAGCTTCAGCTTATTGATGATCAGTTTGCAGATGCTTACCCTCAGCGTATCAAGTTCGAATCTTTAGAAATA
AAGCTAAATGAGTATAAGAGAGAAATAGAAGAGCAACTTCGGGCAGAAATGTGTCAAAAGTTGAAGTTTTTTAAAGATACCGAGATAGCA
AAAATTAAAATGGAAGCAAAAAAAAAGTATGAAAAGGAGTTAACCATGTTCCAGAATGATTTTGAAAAAGCTTGTCAAGCAAAATCTGAA
GCTCTCGTTCTTCGGGAAAAGAGTACCCTTGAAAGAATTCACAAGCACCAAGAGATTGAAACAAAAGAAATTTATGCTCAAAGGCAACTT
TTACTAAAAGATATGGATTTGCTAAGAGGAAGAGAAGCAGAGCTGAAGCAAAGAGTTGAAGCTTTTGAATTGAACCAGAAGCTCCAGGAA
GAAAAACATAAAAGCATAACTGAGGCACTTAGGAGACAGGAGCAGAATATAAAGAGTTTTGAGGAGACCTATGACCGAAAGCTCAAGAAT
GAACTTCTAAACTTCCACAGGCTGCATGGTGTCTGCCTGGCTTTGGGAATCCTCATATGACTTTGGCAGGTGTTGGAGTTTGGAGGCTCT
TCGCCACAGGAGTGCTTCTATTTCCTTTTGGAACCAAAAGGGCAGCTGGTAACAGCTGGGAAAGGGAAGTGAAACTGTGAAAATGTGCCT
TTTGGTATTGCTAATCCGGATATAATGCTCTTG

>30291_30291_8_FGFR2-OFD1_FGFR2_chr10_123243212_ENST00000346997_OFD1_chrX_13754597_ENST00000398395_length(amino acids)=1095AA_BP=765
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLS
STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV
LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM
DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNETQLRNQLIHELMHPVLSGELQPRSISVEGSSLLIGASNSLVADHL
QRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSL
AEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVL
REKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLN
FHRLHGVCLALGILI

--------------------------------------------------------------
>30291_30291_9_FGFR2-OFD1_FGFR2_chr10_123243212_ENST00000369056_OFD1_chrX_13754597_ENST00000380550_length(transcript)=5389nt_BP=2328nt
GGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGG
CCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCT
GCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAAC
AATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACT
GTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGAT
TTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCC
AACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCAT
CGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTA
GTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTG
CCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAG
CACGTGGAAAAGAACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGCACTCGGGGATAAATAGTTCCAATGCA
GAAGTGCTGGCTCTGTTCAATGTGACCGAGGCGGATGCTGGGGAATATATATGTAAGGTCTCCAATTATATAGGGCAGGCCAACCAGTCT
GCCTGGCTCACTGTCCTGCCAAAACAGCAAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTAC
TGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGC
CAGCCGGCTGTGCACAAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAAC
ACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGAC
CCAAAATGGGAGTTTCCAAGAGATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTG
GGAATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTG
GTGTCAGAGATGGAGATGATGAAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTAT
GTCATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAAC
CGTGTTCCTGAGGAGCAGATGACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAA
TGTATTCATCGAGATTTAGCAGCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATC
AACAATATAGACTATTACAAAAAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACT
CATCAGAGTGATGTCTGGTCCTTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAA
CTTTTTAAGCTGCTGAAGGAAGGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCAT
GCAGTGCCCTCCCAGAGACCAACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGACACAACTTCGA
AACCAGCTAATTCATGAGTTGATGCACCCTGTATTGAGTGGAGAACTGCAGCCTCGGTCCATTTCAGTAGAAGGGAGCTCCCTCTTAATA
GGCGCCTCTAACTCTTTAGTGGCAGATCACTTACAAAGATGTGGCTATGAATATTCACTTTCTGTTTTCTTTCCAGAAAGTGGTTTGGCA
AAAGAAAAGGTATTTACTATGCAGGATCTATTACAACTCATTAAAATCAACCCTACTTCCAGTCTCTACAAATCACTGGTTTCAGGATCT
GATAAAGAAAATCAAAAAGGTTTTCTTATGCATTTTTTAAAAGAATTGGCAGAATATCATCAAGCTAAAGAGAGTTGTAATATGGAAACT
CAGACAAGTTCGACATTTAACAGAGATTCTCTGGCTGAGAAGCTTCAGCTTATTGATGATCAGTTTGCAGATGCTTACCCTCAGCGTATC
AAGTTCGAATCTTTAGAAATAAAGCTAAATGAGTATAAGAGAGAAATAGAAGAGCAACTTCGGGCAGAAATGTGTCAAAAGTTGAAGTTT
TTTAAAGATACCGAGATAGCAAAAATTAAAATGGAAGCAAAAAAAAAGTATGAAAAGGAGTTAACCATGTTCCAGAATGATTTTGAAAAA
GCTTGTCAAGCAAAATCTGAAGCTCTCGTTCTTCGGGAAAAGAGTACCCTTGAAAGAATTCACAAGCACCAAGAGATTGAAACAAAAGAA
ATTTATGCTCAAAGGCAACTTTTACTAAAAGATATGGATTTGCTAAGAGGAAGAGAAGCAGAGCTGAAGCAAAGAGTTGAAGCTTTTGAA
TTGTATCAACTTGAACTGAAGGATGACTACATCATTAGAACTAATCGACTGATTGAAGATGAAAGGAAGAATAAAGAAAAAGCTGTTCAT
TTGCAAGAGGAGCTCATAGCTATTAATTCAAAAAAGGAGGAACTCAATCAATCTGTAAATCGTGTGAAAGAACTTGAGCTTGAATTAGAG
TCTGTCAAAGCCCAGTCTTTGGCAATAACAAAACAAAACCATATGCTGAATGAAAAGGTTAAAGAGATGAGTGATTATTCACTACTAAAA
GAAGAGAAACTGGAGCTTCTGGCACAAAATAAATTACTTAAACAACAACTGGAAGAGAGTAGAAATGAAAACCTGCGTCTCCTAAACCGC
CTAGCTCAGCCGGCTCCTGAACTTGCAGTCTTTCAGAAAGAACTACGGAAAGCCGAAAAGGCTATAGTGGTTGAGCATGAGGAGTTCGAA
AGCTGCAGGCAAGCTCTGCACAAACAACTGCAAGACGAAATTGAGCATTCTGCACAGCTGAAGGCCCAGATTCTAGGTTACAAAGCTTCT
GTAAAGAGTTTAACTACTCAGGTTGCCGATTTAAAATTGCAACTGAAGCAAACTCAGACAGCCCTAGAGAATGAAGTGTACTGCAATCCA
AAGCAGTCTGTGATCGATCGTTCTGTCAATGGATTAATAAATGGCAATGTGGTGCCTTGCAATGGTGAGATAAGTGGGGATTTCTTGAAC
AATCCTTTTAAACAGGAAAACGTTCTAGCACGTATGGTTGCATCAAGGATCACAAATTATCCAACTGCATGGGTGGAGGGTAGTTCCCCT
GATTCTGACCTTGAGTTTGTAGCCAATACTAAGGCAAGGGTCAAAGAGCTTCAGCAAGAGGCCGAACGCTTGGAAAAGGCTTTCAGAAGT
TACCATCGGAGAGTCATTAAAAACTCTGCCAAAAGCCCACTAGCAGCAAAGAGCCCACCATCTCTGCACTTGCTGGAAGCCTTCAAAAAC
ATTACTTCCAGTTCCCCGGAAAGACATATTTTTGGAGAGGACAGAGTTGTCTCTGAGCAGCCTCAAGTGGGCACACTTGAAGAAAGGAAT
GACGTCGTGGAAGCACTGACAGGCAGTGCAGCCTCGAGGCTCCGCGGGGGCACTTCCTCCAGACGCCTCTCTTCCACACCCCTTCCAAAA
GCAAAAAGAAGCCTCGAAAGTGAAATGTATCTGGAAGGTCTGGGCAGATCACACATTGCTTCCCCCAGTCCTTGTCCTGACAGAATGCCC
CTACCATCACCCACTGAGTCTAGGCACAGCCTCTCCATCCCTCCTGTCTCCAGCCCTCCGGAGCAGAAAGTGGGTCTTTATCGAAGACAA
ACTGAACTTCAAGACAAAAGTGAATTTTCAGATGTGGACAAGCTAGCTTTTAAGGATAATGAGGAGTTTGAATCATCTTTTGAATCTGCA
GGGAACATGCCAAGGCAGTTGGAAATGGGCGGGCTTTCTCCTGCCGGGGATATGTCTCATGTGGACGCTGCTGCAGCTGCTGTGCCCCTC
TCATATCAGCACCCAAGTGTAGATCAGAAACAAATTGAAGAACAAAAGGAAGAAGAAAAAATACGGGAACAGCAAGTGAAAGAACGAAGG
CAGAGAGAAGAAAGAAGGCAGAGTAACCTACAAGAAGTTTTAGAAAGGGAACGAAGAGAACTAGAAAAACTGTATCAGGAAAGGAAGATG
ATTGAAGAATCACTGAAGATTAAAATAAAAAAGGAATTAGAAATGGAAAATGAATTAGAAATGAGTAATCAAGAAATAAAAGACAAATCT
GCTCACAGTGAAAATCCTTTAGAGAAATACATGAAAATCATCCAGCAGGAGCAAGACCAGGAGTCGGCAGATAAGAGCTCAAAAAAGATG
GTCCAAGAAGGCTCCCTAGTGGACACGCTGCAATCTAGTGACAAAGTCGAAAGTTTAACAGGCTTTTCTCATGAAGAACTAGACGACTCT
TGGTAACCATGTTTGCTGCCCAGCTTCTAACTTACATACCGTGAGAAGTTACGTAACATTTACTCCTTTGTAAATGTTTCCCTATCATCA
GACAAAACTCAATAAAAATGTGTGTAATCCAATGTGGGTTTTTTTTTCCATAATTAATTTTGATACCATAGTGTGTGAACCAAGAATAAT
CTAGTCACGTGAAACCTCTTCTCCAGTCATAGTATTTCTCATTCATTATAATAAAAGTAACTGGCTTTTAACCTCCTTA

>30291_30291_9_FGFR2-OFD1_FGFR2_chr10_123243212_ENST00000369056_OFD1_chrX_13754597_ENST00000380550_length(amino acids)=1703AA_BP=768
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK
QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG
HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNETQLRNQLIHELMHPVLSGELQPRSISVEGSSLLIGASNSLVA
DHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNR
DSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEA
LVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAI
NSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPEL
AVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRS
VNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKN
SAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESE
MYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLE
MGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIK
IKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDSW

--------------------------------------------------------------
>30291_30291_10_FGFR2-OFD1_FGFR2_chr10_123243212_ENST00000369056_OFD1_chrX_13754597_ENST00000398395_length(transcript)=3474nt_BP=2328nt
GGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGG
CCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCT
GCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAAC
AATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACT
GTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGAT
TTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCC
AACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCAT
CGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTA
GTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTG
CCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAG
CACGTGGAAAAGAACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGCACTCGGGGATAAATAGTTCCAATGCA
GAAGTGCTGGCTCTGTTCAATGTGACCGAGGCGGATGCTGGGGAATATATATGTAAGGTCTCCAATTATATAGGGCAGGCCAACCAGTCT
GCCTGGCTCACTGTCCTGCCAAAACAGCAAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTAC
TGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGC
CAGCCGGCTGTGCACAAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAAC
ACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGAC
CCAAAATGGGAGTTTCCAAGAGATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTG
GGAATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTG
GTGTCAGAGATGGAGATGATGAAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTAT
GTCATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAAC
CGTGTTCCTGAGGAGCAGATGACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAA
TGTATTCATCGAGATTTAGCAGCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATC
AACAATATAGACTATTACAAAAAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACT
CATCAGAGTGATGTCTGGTCCTTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAA
CTTTTTAAGCTGCTGAAGGAAGGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCAT
GCAGTGCCCTCCCAGAGACCAACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGACACAACTTCGA
AACCAGCTAATTCATGAGTTGATGCACCCTGTATTGAGTGGAGAACTGCAGCCTCGGTCCATTTCAGTAGAAGGGAGCTCCCTCTTAATA
GGCGCCTCTAACTCTTTAGTGGCAGATCACTTACAAAGATGTGGCTATGAATATTCACTTTCTGTTTTCTTTCCAGAAAGTGGTTTGGCA
AAAGAAAAGGTATTTACTATGCAGGATCTATTACAACTCATTAAAATCAACCCTACTTCCAGTCTCTACAAATCACTGGTTTCAGGATCT
GATAAAGAAAATCAAAAAGGTTTTCTTATGCATTTTTTAAAAGAATTGGCAGAATATCATCAAGCTAAAGAGAGTTGTAATATGGAAACT
CAGACAAGTTCGACATTTAACAGAGATTCTCTGGCTGAGAAGCTTCAGCTTATTGATGATCAGTTTGCAGATGCTTACCCTCAGCGTATC
AAGTTCGAATCTTTAGAAATAAAGCTAAATGAGTATAAGAGAGAAATAGAAGAGCAACTTCGGGCAGAAATGTGTCAAAAGTTGAAGTTT
TTTAAAGATACCGAGATAGCAAAAATTAAAATGGAAGCAAAAAAAAAGTATGAAAAGGAGTTAACCATGTTCCAGAATGATTTTGAAAAA
GCTTGTCAAGCAAAATCTGAAGCTCTCGTTCTTCGGGAAAAGAGTACCCTTGAAAGAATTCACAAGCACCAAGAGATTGAAACAAAAGAA
ATTTATGCTCAAAGGCAACTTTTACTAAAAGATATGGATTTGCTAAGAGGAAGAGAAGCAGAGCTGAAGCAAAGAGTTGAAGCTTTTGAA
TTGAACCAGAAGCTCCAGGAAGAAAAACATAAAAGCATAACTGAGGCACTTAGGAGACAGGAGCAGAATATAAAGAGTTTTGAGGAGACC
TATGACCGAAAGCTCAAGAATGAACTTCTAAACTTCCACAGGCTGCATGGTGTCTGCCTGGCTTTGGGAATCCTCATATGACTTTGGCAG
GTGTTGGAGTTTGGAGGCTCTTCGCCACAGGAGTGCTTCTATTTCCTTTTGGAACCAAAAGGGCAGCTGGTAACAGCTGGGAAAGGGAAG
TGAAACTGTGAAAATGTGCCTTTTGGTATTGCTAATCCGGATATAATGCTCTTG

>30291_30291_10_FGFR2-OFD1_FGFR2_chr10_123243212_ENST00000369056_OFD1_chrX_13754597_ENST00000398395_length(amino acids)=1098AA_BP=768
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK
QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG
HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNETQLRNQLIHELMHPVLSGELQPRSISVEGSSLLIGASNSLVA
DHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNR
DSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEA
LVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNE
LLNFHRLHGVCLALGILI

--------------------------------------------------------------
>30291_30291_11_FGFR2-OFD1_FGFR2_chr10_123243212_ENST00000369061_OFD1_chrX_13754597_ENST00000380550_length(transcript)=5176nt_BP=2115nt
TGACTGCAGCAGCAGCGGCAGCGCCTCGGTTCCTGAGCCCACCGCAGGCTGAAGGCATTGCGCGTAGTCCATGCCCGTAGAGGAAGTGTG
CAGATGGGATTAACGTCCACATGGAGATATGGAAGAGGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTG
GTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACC
AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATC
AGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA
GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCC
GGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAA
AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGG
TGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT
GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGCG
CCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTG
GTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAACGTATC
CCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACACGCCTCTCT
TCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAGCTGACA
CTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTC
ACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATGATTGGG
AAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTC
CGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTCAAGGAC
TTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCAGCCAGAAATGTT
TTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAAAAGACCACCAAT
GGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCCTTCGGGGTGTTA
ATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAAGGACACAGAATG
GATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCAACGTTCAAGCAG
TTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGACACAACTTCGAAACCAGCTAATTCATGAGTTGATGCACCCTGTA
TTGAGTGGAGAACTGCAGCCTCGGTCCATTTCAGTAGAAGGGAGCTCCCTCTTAATAGGCGCCTCTAACTCTTTAGTGGCAGATCACTTA
CAAAGATGTGGCTATGAATATTCACTTTCTGTTTTCTTTCCAGAAAGTGGTTTGGCAAAAGAAAAGGTATTTACTATGCAGGATCTATTA
CAACTCATTAAAATCAACCCTACTTCCAGTCTCTACAAATCACTGGTTTCAGGATCTGATAAAGAAAATCAAAAAGGTTTTCTTATGCAT
TTTTTAAAAGAATTGGCAGAATATCATCAAGCTAAAGAGAGTTGTAATATGGAAACTCAGACAAGTTCGACATTTAACAGAGATTCTCTG
GCTGAGAAGCTTCAGCTTATTGATGATCAGTTTGCAGATGCTTACCCTCAGCGTATCAAGTTCGAATCTTTAGAAATAAAGCTAAATGAG
TATAAGAGAGAAATAGAAGAGCAACTTCGGGCAGAAATGTGTCAAAAGTTGAAGTTTTTTAAAGATACCGAGATAGCAAAAATTAAAATG
GAAGCAAAAAAAAAGTATGAAAAGGAGTTAACCATGTTCCAGAATGATTTTGAAAAAGCTTGTCAAGCAAAATCTGAAGCTCTCGTTCTT
CGGGAAAAGAGTACCCTTGAAAGAATTCACAAGCACCAAGAGATTGAAACAAAAGAAATTTATGCTCAAAGGCAACTTTTACTAAAAGAT
ATGGATTTGCTAAGAGGAAGAGAAGCAGAGCTGAAGCAAAGAGTTGAAGCTTTTGAATTGTATCAACTTGAACTGAAGGATGACTACATC
ATTAGAACTAATCGACTGATTGAAGATGAAAGGAAGAATAAAGAAAAAGCTGTTCATTTGCAAGAGGAGCTCATAGCTATTAATTCAAAA
AAGGAGGAACTCAATCAATCTGTAAATCGTGTGAAAGAACTTGAGCTTGAATTAGAGTCTGTCAAAGCCCAGTCTTTGGCAATAACAAAA
CAAAACCATATGCTGAATGAAAAGGTTAAAGAGATGAGTGATTATTCACTACTAAAAGAAGAGAAACTGGAGCTTCTGGCACAAAATAAA
TTACTTAAACAACAACTGGAAGAGAGTAGAAATGAAAACCTGCGTCTCCTAAACCGCCTAGCTCAGCCGGCTCCTGAACTTGCAGTCTTT
CAGAAAGAACTACGGAAAGCCGAAAAGGCTATAGTGGTTGAGCATGAGGAGTTCGAAAGCTGCAGGCAAGCTCTGCACAAACAACTGCAA
GACGAAATTGAGCATTCTGCACAGCTGAAGGCCCAGATTCTAGGTTACAAAGCTTCTGTAAAGAGTTTAACTACTCAGGTTGCCGATTTA
AAATTGCAACTGAAGCAAACTCAGACAGCCCTAGAGAATGAAGTGTACTGCAATCCAAAGCAGTCTGTGATCGATCGTTCTGTCAATGGA
TTAATAAATGGCAATGTGGTGCCTTGCAATGGTGAGATAAGTGGGGATTTCTTGAACAATCCTTTTAAACAGGAAAACGTTCTAGCACGT
ATGGTTGCATCAAGGATCACAAATTATCCAACTGCATGGGTGGAGGGTAGTTCCCCTGATTCTGACCTTGAGTTTGTAGCCAATACTAAG
GCAAGGGTCAAAGAGCTTCAGCAAGAGGCCGAACGCTTGGAAAAGGCTTTCAGAAGTTACCATCGGAGAGTCATTAAAAACTCTGCCAAA
AGCCCACTAGCAGCAAAGAGCCCACCATCTCTGCACTTGCTGGAAGCCTTCAAAAACATTACTTCCAGTTCCCCGGAAAGACATATTTTT
GGAGAGGACAGAGTTGTCTCTGAGCAGCCTCAAGTGGGCACACTTGAAGAAAGGAATGACGTCGTGGAAGCACTGACAGGCAGTGCAGCC
TCGAGGCTCCGCGGGGGCACTTCCTCCAGACGCCTCTCTTCCACACCCCTTCCAAAAGCAAAAAGAAGCCTCGAAAGTGAAATGTATCTG
GAAGGTCTGGGCAGATCACACATTGCTTCCCCCAGTCCTTGTCCTGACAGAATGCCCCTACCATCACCCACTGAGTCTAGGCACAGCCTC
TCCATCCCTCCTGTCTCCAGCCCTCCGGAGCAGAAAGTGGGTCTTTATCGAAGACAAACTGAACTTCAAGACAAAAGTGAATTTTCAGAT
GTGGACAAGCTAGCTTTTAAGGATAATGAGGAGTTTGAATCATCTTTTGAATCTGCAGGGAACATGCCAAGGCAGTTGGAAATGGGCGGG
CTTTCTCCTGCCGGGGATATGTCTCATGTGGACGCTGCTGCAGCTGCTGTGCCCCTCTCATATCAGCACCCAAGTGTAGATCAGAAACAA
ATTGAAGAACAAAAGGAAGAAGAAAAAATACGGGAACAGCAAGTGAAAGAACGAAGGCAGAGAGAAGAAAGAAGGCAGAGTAACCTACAA
GAAGTTTTAGAAAGGGAACGAAGAGAACTAGAAAAACTGTATCAGGAAAGGAAGATGATTGAAGAATCACTGAAGATTAAAATAAAAAAG
GAATTAGAAATGGAAAATGAATTAGAAATGAGTAATCAAGAAATAAAAGACAAATCTGCTCACAGTGAAAATCCTTTAGAGAAATACATG
AAAATCATCCAGCAGGAGCAAGACCAGGAGTCGGCAGATAAGAGCTCAAAAAAGATGGTCCAAGAAGGCTCCCTAGTGGACACGCTGCAA
TCTAGTGACAAAGTCGAAAGTTTAACAGGCTTTTCTCATGAAGAACTAGACGACTCTTGGTAACCATGTTTGCTGCCCAGCTTCTAACTT
ACATACCGTGAGAAGTTACGTAACATTTACTCCTTTGTAAATGTTTCCCTATCATCAGACAAAACTCAATAAAAATGTGTGTAATCCAAT
GTGGGTTTTTTTTTCCATAATTAATTTTGATACCATAGTGTGTGAACCAAGAATAATCTAGTCACGTGAAACCTCTTCTCCAGTCATAGT
ATTTCTCATTCATTATAATAAAAGTAACTGGCTTTTAACCTCCTTA

>30291_30291_11_FGFR2-OFD1_FGFR2_chr10_123243212_ENST00000369061_OFD1_chrX_13754597_ENST00000380550_length(amino acids)=1624AA_BP=689
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNETQLRNQLIHELMHPVLSGELQPRSISVEGSS
LLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCN
METQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQND
FEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELYQLELKDDYIIRTNRLIEDERKNKEK
AVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRL
LNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVY
CNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKA
FRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTP
LPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSF
ESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQE
RKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEEL
DDSW

--------------------------------------------------------------
>30291_30291_12_FGFR2-OFD1_FGFR2_chr10_123243212_ENST00000369061_OFD1_chrX_13754597_ENST00000398395_length(transcript)=3261nt_BP=2115nt
TGACTGCAGCAGCAGCGGCAGCGCCTCGGTTCCTGAGCCCACCGCAGGCTGAAGGCATTGCGCGTAGTCCATGCCCGTAGAGGAAGTGTG
CAGATGGGATTAACGTCCACATGGAGATATGGAAGAGGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTG
GTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACC
AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATC
AGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA
GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCC
GGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAA
AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGG
TGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT
GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGCG
CCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTG
GTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAACGTATC
CCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACACGCCTCTCT
TCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAGCTGACA
CTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTC
ACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATGATTGGG
AAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTC
CGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTCAAGGAC
TTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCAGCCAGAAATGTT
TTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAAAAGACCACCAAT
GGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCCTTCGGGGTGTTA
ATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAAGGACACAGAATG
GATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCAACGTTCAAGCAG
TTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGACACAACTTCGAAACCAGCTAATTCATGAGTTGATGCACCCTGTA
TTGAGTGGAGAACTGCAGCCTCGGTCCATTTCAGTAGAAGGGAGCTCCCTCTTAATAGGCGCCTCTAACTCTTTAGTGGCAGATCACTTA
CAAAGATGTGGCTATGAATATTCACTTTCTGTTTTCTTTCCAGAAAGTGGTTTGGCAAAAGAAAAGGTATTTACTATGCAGGATCTATTA
CAACTCATTAAAATCAACCCTACTTCCAGTCTCTACAAATCACTGGTTTCAGGATCTGATAAAGAAAATCAAAAAGGTTTTCTTATGCAT
TTTTTAAAAGAATTGGCAGAATATCATCAAGCTAAAGAGAGTTGTAATATGGAAACTCAGACAAGTTCGACATTTAACAGAGATTCTCTG
GCTGAGAAGCTTCAGCTTATTGATGATCAGTTTGCAGATGCTTACCCTCAGCGTATCAAGTTCGAATCTTTAGAAATAAAGCTAAATGAG
TATAAGAGAGAAATAGAAGAGCAACTTCGGGCAGAAATGTGTCAAAAGTTGAAGTTTTTTAAAGATACCGAGATAGCAAAAATTAAAATG
GAAGCAAAAAAAAAGTATGAAAAGGAGTTAACCATGTTCCAGAATGATTTTGAAAAAGCTTGTCAAGCAAAATCTGAAGCTCTCGTTCTT
CGGGAAAAGAGTACCCTTGAAAGAATTCACAAGCACCAAGAGATTGAAACAAAAGAAATTTATGCTCAAAGGCAACTTTTACTAAAAGAT
ATGGATTTGCTAAGAGGAAGAGAAGCAGAGCTGAAGCAAAGAGTTGAAGCTTTTGAATTGAACCAGAAGCTCCAGGAAGAAAAACATAAA
AGCATAACTGAGGCACTTAGGAGACAGGAGCAGAATATAAAGAGTTTTGAGGAGACCTATGACCGAAAGCTCAAGAATGAACTTCTAAAC
TTCCACAGGCTGCATGGTGTCTGCCTGGCTTTGGGAATCCTCATATGACTTTGGCAGGTGTTGGAGTTTGGAGGCTCTTCGCCACAGGAG
TGCTTCTATTTCCTTTTGGAACCAAAAGGGCAGCTGGTAACAGCTGGGAAAGGGAAGTGAAACTGTGAAAATGTGCCTTTTGGTATTGCT
AATCCGGATATAATGCTCTTG

>30291_30291_12_FGFR2-OFD1_FGFR2_chr10_123243212_ENST00000369061_OFD1_chrX_13754597_ENST00000398395_length(amino acids)=1019AA_BP=689
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNETQLRNQLIHELMHPVLSGELQPRSISVEGSS
LLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCN
METQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQND
FEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSF
EETYDRKLKNELLNFHRLHGVCLALGILI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FGFR2-OFD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGFR2-OFD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGFR2P21802DB00039PaliferminAgonist|BinderBiotechApproved
HgeneFGFR2P21802DB00039PaliferminAgonist|BinderBiotechApproved
HgeneFGFR2P21802DB00039PaliferminAgonist|BinderBiotechApproved
HgeneFGFR2P21802DB00039PaliferminAgonist|BinderBiotechApproved
HgeneFGFR2P21802DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneFGFR2P21802DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneFGFR2P21802DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneFGFR2P21802DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneFGFR2P21802DB09079NintedanibInhibitorSmall moleculeApproved
HgeneFGFR2P21802DB09079NintedanibInhibitorSmall moleculeApproved
HgeneFGFR2P21802DB09079NintedanibInhibitorSmall moleculeApproved
HgeneFGFR2P21802DB09079NintedanibInhibitorSmall moleculeApproved
HgeneFGFR2P21802DB10770Foreskin fibroblast (neonatal)AgonistBiotechApproved
HgeneFGFR2P21802DB10770Foreskin fibroblast (neonatal)AgonistBiotechApproved
HgeneFGFR2P21802DB10770Foreskin fibroblast (neonatal)AgonistBiotechApproved
HgeneFGFR2P21802DB10770Foreskin fibroblast (neonatal)AgonistBiotechApproved
HgeneFGFR2P21802DB10772Foreskin keratinocyte (neonatal)AgonistBiotechApproved
HgeneFGFR2P21802DB10772Foreskin keratinocyte (neonatal)AgonistBiotechApproved
HgeneFGFR2P21802DB10772Foreskin keratinocyte (neonatal)AgonistBiotechApproved
HgeneFGFR2P21802DB10772Foreskin keratinocyte (neonatal)AgonistBiotechApproved
HgeneFGFR2P21802DB01109HeparinSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB01109HeparinSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB01109HeparinSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB01109HeparinSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB08901PonatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB08901PonatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB08901PonatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB08901PonatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB09078LenvatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB09078LenvatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB09078LenvatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB09078LenvatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB12147ErdafitinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB12147ErdafitinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB12147ErdafitinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB12147ErdafitinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB15102PemigatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB15102PemigatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB15102PemigatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB15102PemigatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB15685SelpercatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB15685SelpercatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB15685SelpercatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB15685SelpercatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB15822PralsetinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB15822PralsetinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB15822PralsetinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB15822PralsetinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR2P21802DB01041ThalidomideAntagonistSmall moleculeApproved|Investigational|Withdrawn
HgeneFGFR2P21802DB01041ThalidomideAntagonistSmall moleculeApproved|Investigational|Withdrawn
HgeneFGFR2P21802DB01041ThalidomideAntagonistSmall moleculeApproved|Investigational|Withdrawn
HgeneFGFR2P21802DB01041ThalidomideAntagonistSmall moleculeApproved|Investigational|Withdrawn

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Related Diseases for FGFR2-OFD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR2C2931196Craniofacial dysostosis type 123CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR2C0220658Pfeiffer Syndrome21CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR2C0001193Apert syndrome19CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C0795998JACKSON-WEISS SYNDROME10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C0175699Saethre-Chotzen Syndrome8CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneFGFR2C1852406Cutis Gyrata Syndrome of Beare And Stevenson8CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C2936791Antley-Bixler Syndrome, Autosomal Dominant7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C1510455Acrocephalosyndactylia6CTD_human;ORPHANET
HgeneFGFR2C0265269Lacrimoauriculodentodigital syndrome5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C0010278Craniosynostosis4CTD_human;GENOMICS_ENGLAND
HgeneFGFR2C1863389Apert-Crouzon Disease4CTD_human
HgeneFGFR2C1865070SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C0006142Malignant neoplasm of breast3CTD_human;UNIPROT
HgeneFGFR2C0030044Acrocephaly3CTD_human
HgeneFGFR2C0036341Schizophrenia3PSYGENET
HgeneFGFR2C0221356Brachycephaly3CTD_human
HgeneFGFR2C0265534Scaphycephaly3CTD_human
HgeneFGFR2C0265535Trigonocephaly3CTD_human
HgeneFGFR2C0376634Craniofacial Abnormalities3CTD_human
HgeneFGFR2C0678222Breast Carcinoma3CTD_human
HgeneFGFR2C1257931Mammary Neoplasms, Human3CTD_human
HgeneFGFR2C1458155Mammary Neoplasms3CTD_human
HgeneFGFR2C1833340Synostotic Posterior Plagiocephaly3CTD_human
HgeneFGFR2C1860819Metopic synostosis3CTD_human
HgeneFGFR2C2931150Synostotic Anterior Plagiocephaly3CTD_human
HgeneFGFR2C3281247BENT BONE DYSPLASIA SYNDROME3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C4551902Craniosynostosis, Type 13CTD_human
HgeneFGFR2C4704874Mammary Carcinoma, Human3CTD_human
HgeneFGFR2C0008925Cleft Palate2CTD_human
HgeneFGFR2C0011570Mental Depression2PSYGENET
HgeneFGFR2C0011581Depressive disorder2PSYGENET
HgeneFGFR2C0024623Malignant neoplasm of stomach2CGI;CTD_human
HgeneFGFR2C0038356Stomach Neoplasms2CGI;CTD_human
HgeneFGFR2C1708349Hereditary Diffuse Gastric Cancer2CTD_human
HgeneFGFR2C1837218Cleft palate, isolated2CTD_human
HgeneFGFR2C0000772Multiple congenital anomalies1CTD_human
HgeneFGFR2C0003090Ankylosis1CTD_human
HgeneFGFR2C0005586Bipolar Disorder1PSYGENET
HgeneFGFR2C0008924Cleft upper lip1CTD_human
HgeneFGFR2C0010273Craniofacial Dysostosis1CTD_human
HgeneFGFR2C0011757Developmental Coordination Disorder1CTD_human
HgeneFGFR2C0014170Endometrial Neoplasms1CTD_human
HgeneFGFR2C0018553Hamartoma Syndrome, Multiple1CTD_human
HgeneFGFR2C0020796Profound Mental Retardation1CTD_human
HgeneFGFR2C0023890Liver Cirrhosis1CTD_human
HgeneFGFR2C0024121Lung Neoplasms1CTD_human
HgeneFGFR2C0025363Mental Retardation, Psychosocial1CTD_human
HgeneFGFR2C0026613Motor Skills Disorders1CTD_human
HgeneFGFR2C0033975Psychotic Disorders1PSYGENET
HgeneFGFR2C0037268Skin Abnormalities1CTD_human
HgeneFGFR2C0037274Dermatologic disorders1CTD_human
HgeneFGFR2C0038219Status Dysraphicus1CTD_human
HgeneFGFR2C0040427Tooth Abnormalities1CTD_human
HgeneFGFR2C0080178Spina Bifida1CTD_human
HgeneFGFR2C0152423Congenital small ears1GENOMICS_ENGLAND
HgeneFGFR2C0206698Cholangiocarcinoma1CTD_human
HgeneFGFR2C0206762Limb Deformities, Congenital1CTD_human
HgeneFGFR2C0239946Fibrosis, Liver1CTD_human
HgeneFGFR2C0242379Malignant neoplasm of lung1CTD_human
HgeneFGFR2C0265326Bannayan-Riley-Ruvalcaba Syndrome1CTD_human
HgeneFGFR2C0266508Rachischisis1CTD_human
HgeneFGFR2C0345905Intrahepatic Cholangiocarcinoma1CTD_human
HgeneFGFR2C0349204Nonorganic psychosis1PSYGENET
HgeneFGFR2C0391826Lhermitte-Duclos disease1CTD_human
HgeneFGFR2C0476089Endometrial Carcinoma1CGI;CTD_human
HgeneFGFR2C0524730Odontome1CTD_human
HgeneFGFR2C0699791Stomach Carcinoma1CGI;GENOMICS_ENGLAND
HgeneFGFR2C0917816Mental deficiency1CTD_human
HgeneFGFR2C1450010Plagiocephaly, Nonsynostotic1CTD_human
HgeneFGFR2C1860042Antley-Bixler Syndrome with Disordered Steroidogenesis1CTD_human
HgeneFGFR2C1867564SCAPHOCEPHALY AND AXENFELD-RIEGER ANOMALY1GENOMICS_ENGLAND
HgeneFGFR2C1959582PTEN Hamartoma Tumor Syndrome1CTD_human
HgeneFGFR2C2350233Antley-Bixler Syndrome Phenotype1CTD_human
HgeneFGFR2C3267076Familial scaphocephaly syndrome1GENOMICS_ENGLAND
HgeneFGFR2C3714756Intellectual Disability1CTD_human
HgeneFGFR2C3805278Extrahepatic Cholangiocarcinoma1CTD_human
TgeneC1510460Orofaciodigital Syndrome I8GENOMICS_ENGLAND;UNIPROT
TgeneC2749019JOUBERT SYNDROME 10 (disorder)6CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC4277690Ciliopathies4CLINGEN;GENOMICS_ENGLAND
TgeneC1846175SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 2 (disorder)3CTD_human;GENOMICS_ENGLAND
TgeneC0035334Retinitis Pigmentosa1GENOMICS_ENGLAND;ORPHANET
TgeneC0265251Oto-Palato-digital syndrome type 11CTD_human
TgeneC1419610RP23 gene1CTD_human;GENOMICS_ENGLAND