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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ALDOA-SIAE (FusionGDB2 ID:HG226TG54414)

Fusion Gene Summary for ALDOA-SIAE

Fusion gene summary

Fusion gene information	Fusion gene name: ALDOA-SIAE
	Fusion gene ID: hg226tg54414
		Hgene	Tgene
	Gene symbol	ALDOA	SIAE
	Gene ID	226	54414
	Gene name	aldolase, fructose-bisphosphate A	sialic acid acetylesterase
	Synonyms	ALDA\|GSD12\|HEL-S-87p	AIS6\|CSE-C\|CSEC\|LSE\|YSG2
	Cytomap	('ALDOA')('SIAE') 16p11.2	11q24.2
	Type of gene	protein-coding	protein-coding
	Description	fructose-bisphosphate aldolase Aaldolase A, fructose-bisphosphateepididymis secretory sperm binding protein Li 87pfructose-1,6-bisphosphate triosephosphate-lyaselung cancer antigen NY-LU-1muscle-type aldolase	sialate O-acetylesteraseH-Lsecytosolic sialic acid 9-O-acetylesterase homologsialic acid-specific acetylesterase II
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000395248, ENST00000564546, ENST00000338110, ENST00000412304, ENST00000563060, ENST00000564595, ENST00000566897, ENST00000395240, ENST00000569545, ENST00000569798, ENST00000575627,
Fusion gene scores	* DoF score	37 X 23 X 12=10212	34 X 6 X 15=3060
	# samples	42	34
	** MAII score	log2(42/10212*10)=-4.603732304741 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(34/3060*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ALDOA [Title/Abstract] AND SIAE [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ALDOA(30081734)-SIAE(124543777), # samples:2
Anticipated loss of major functional domain due to fusion event.	ALDOA-SIAE seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ALDOA-SIAE seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ALDOA	GO:0008360	regulation of cell shape	9244396
Hgene	ALDOA	GO:0030388	fructose 1,6-bisphosphate metabolic process	9244396\|14766013
Tgene	SIAE	GO:0005975	carbohydrate metabolic process	23308225

Fusion gene breakpoints across ALDOA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SIAE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRP	TCGA-A4-8515-01A	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
ChimerDB4	KIRP	TCGA-P4-A5EB-01A	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-

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Fusion Gene ORF analysis for ALDOA-SIAE

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000395248	ENST00000263593	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
3UTR-3CDS	ENST00000564546	ENST00000263593	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
3UTR-intron	ENST00000395248	ENST00000525730	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
3UTR-intron	ENST00000395248	ENST00000545756	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
3UTR-intron	ENST00000564546	ENST00000525730	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
3UTR-intron	ENST00000564546	ENST00000545756	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
5CDS-intron	ENST00000338110	ENST00000525730	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
5CDS-intron	ENST00000338110	ENST00000545756	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
5CDS-intron	ENST00000412304	ENST00000525730	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
5CDS-intron	ENST00000412304	ENST00000545756	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
5CDS-intron	ENST00000563060	ENST00000525730	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
5CDS-intron	ENST00000563060	ENST00000545756	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
5CDS-intron	ENST00000564595	ENST00000525730	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
5CDS-intron	ENST00000564595	ENST00000545756	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
5CDS-intron	ENST00000566897	ENST00000525730	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
5CDS-intron	ENST00000566897	ENST00000545756	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
Frame-shift	ENST00000338110	ENST00000263593	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
Frame-shift	ENST00000412304	ENST00000263593	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
Frame-shift	ENST00000563060	ENST00000263593	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
Frame-shift	ENST00000564595	ENST00000263593	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
In-frame	ENST00000566897	ENST00000263593	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
intron-3CDS	ENST00000395240	ENST00000263593	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
intron-3CDS	ENST00000569545	ENST00000263593	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
intron-3CDS	ENST00000569798	ENST00000263593	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
intron-3CDS	ENST00000575627	ENST00000263593	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
intron-intron	ENST00000395240	ENST00000525730	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
intron-intron	ENST00000395240	ENST00000545756	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
intron-intron	ENST00000569545	ENST00000525730	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
intron-intron	ENST00000569545	ENST00000545756	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
intron-intron	ENST00000569798	ENST00000525730	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
intron-intron	ENST00000569798	ENST00000545756	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
intron-intron	ENST00000575627	ENST00000525730	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-
intron-intron	ENST00000575627	ENST00000545756	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000566897

ALDOA

chr16

30081734

ENST00000263593

SIAE

chr11

124543777

8031

2448

2420

4192

590

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000566897	ENST00000263593	ALDOA	chr16	30081734	-	SIAE	chr11	124543777	-	0.000649328	0.9993507

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Fusion Genomic Features for ALDOA-SIAE

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for ALDOA-SIAE

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:30081734/chr11:124543777)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ALDOA-SIAE

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>3968_3968_1_ALDOA-SIAE_ALDOA_chr16_30081734_ENST00000566897_SIAE_chr11_124543777_ENST00000263593_length(transcript)=8031nt_BP=2448nt
CGCGAACGGCTTCTGGGCGGGGCCGGTCCCTCGGACGATTGGACCTAGCTTGGCGCGGAATCCGTGAATTGCCCGCGGCCCGAGGGTGCA
GGTGATGGGTGCTGACCGACTGGGGAAGCCCGGAGTGTGGGGACTGAGGAGGGGAGTGGCCTGGGGCGCGCTGGAGCCTGCGAGGAAGGC
GCCGCCTCGGATCCCCCGCCCCCCATTCCCCTTCCCGAATTCCACCCTCCGGCCCAGCCATGGCCTCAGTTTCCCCAAACAGGAAAGGGA
AGGAGGGTGGGCACCCCGGTCTAACGGTGCCTCTCAGCCTCTGAGACCCAGAACCTTCCTTCTGCAGCTCCCGGACTGACTGGCTCTGCC
CTTCCCCATGGACGCCCAGGGCTGCTGCGCGGACGGTAGCTCCCCCTGCAGGAAGCAAGGTTCCTCCGGGCCCCCAGACTGCTGCTGGAC
CTGTGCAGAAGCCTGCAACTTTCCTCTGCCTAGCCCGGCCCACTTCCTGGATGCTTGCTGCCCCCAGCCCACCAGAGCTGACTGGGCACC
TCGCTGCCCCCGCTGCTGCCCACTCTGCGACTGTGCCTGTACGTGCCAGCTCCCCGACTGCCAGAGCCTCAACTGTCTCTGCTTCGAGAT
CAAGCTCCGATGAGGACCCAGGGCCCCTGCCCTCTGGGGAGCGGCCAGCCCCCAGGGCCCATGTGCCCTCCTCCCTGAAGAGCCTTTCCC
CACGCCACTGGAACCACAGATGGCCTGCCGAGCACCCAGGCCTGGGAACTGGAAGTGGCAGCGCAGGGCCTGGCTCCCTGCAGGGCAGGA
CTCTTGGCCGGCTGGACGGCAGCTCCTCTGGAGGGCCAGAAAAGAGAGGGGCTAGTGCTCGGGCAGGTGCCCTGGCTTCCCTTCCCCTCC
ACACGTCAACGATTCTATTTGAAGTTGGGCAGGGGGGTGGCGCTGCTCACCACACACAAGTGTTATAGGAGGAGTCTGGCCCTTGAGTAC
CGGGTACGCAGGGGTGCCTCAACCACACTCCGTCCACGGACTCTCCGTTATTTTAGGAGGTCCCTGGCCAAAGATTTATTTCTCTTGACA
ACCAAGGGCCTCCGTCTGGATTTCCAAGGAAGAATTTCCTCTGAAGCACCGGAACTTGCTACTACCAGCACCATGCCCTACCAATATCCA
GCACTGACCCCGGAGCAGAAGAAGGAGCTGTCTGACATCGCTCACCGCATCGTGGCACCTGGCAAGGGCATCCTGGCTGCAGATGAGTCC
ACTGGGAGCATTGCCAAGCGGCTGCAGTCCATTGGCACCGAGAACACCGAGGAGAACCGGCGCTTCTACCGCCAGCTGCTGCTGACAGCT
GACGACCGCGTGAACCCCTGCATTGGGGGTGTCATCCTCTTCCATGAGACACTCTACCAGAAGGCGGATGATGGGCGTCCCTTCCCCCAA
GTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGGTAGACAAGGGCGTGGTCCCCCTGGCAGGGACAAATGGCGAGACTACCACCCAA
GGGTTGGATGGGCTGTCTGAGCGCTGTGCCCAGTACAAGAAGGACGGAGCTGACTTCGCCAAGTGGCGTTGTGTGCTGAAGATTGGGGAA
CACACCCCCTCAGCCCTCGCCATCATGGAAAATGCCAATGTTCTGGCCCGTTATGCCAGTATCTGCCAGCAGAATGGCATTGTGCCCATC
GTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAGAAGGTGCTGGCTGCTGTCTACAAGGCT
CTGAGTGACCACCACATCTACCTGGAAGGCACCTTGCTGAAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAAGTTTTCTCAT
GAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGCACAGTGCCCCCCGCTGTCACTGGGATCACCTTCCTGTCTGGAGGCCAGAGT
GAGGAGGAGGCGTCCATCAACCTCAATGCCATTAACAAGTGCCCCCTGCTGAAGCCCTGGGCCCTGACCTTCTCCTACGGCCGAGCCCTG
CAGGCCTCTGCCCTGAAGGCCTGGGGCGGGAAGAAGGAGAACCTGAAGGCTGCGCAGGAGGAGTATGTCAAGCGAGCCCTGGCCAACAGC
CTTGCCTGTCAAGGAAAGTACACTCCGAGCGGTCAGGCTGGGGCTGCTGCCAGCGAGTCCCTCTTCGTCTCTAACCACGCCTATTAAGCG
GAGGTGTTCCCAGGCTGCCCCCAACACTCCAGGCCCTGCCCCCTCCCACTCTTGAAGAGGAGGCCGCCTCCTCGGGGCTCCAGGCTGGCT
TGCCCGCGCTCTTTCTTCCCTCGTGACAGTGGTGTGTGGTGTCGTCTGTGAATGCTAAGTCCATCACCCTTTCCGGCACACTGCCAAATA
AACAGCTATTTAAGGGGGAAAAAAAAAAAAAAACTACGGCGGCCGAGAAGGGGCGAGTACAGCCCAGTCCTGAGGTCGCGGGAGGCTGCG
AGGACTGCAAAAGGGTGGAGTCGGCCTCGCCCCCGCCCAGGCCCCGCCCCTGCCGGGAACCCACTTTCCCAGTCCTAGGCGGCGGTCAGA
TCCTTGCAAGCATGGTCGCGCCGGGGCTTGTACTCGGGCTGGTGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTC
GCTTTGCTTCATACATCAATAATGATATGGTGCTGCAGAAGGAGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAG
TGACCGTGACCCTGCGCCAAGGTCAGGAAACCATCATGAAGAAAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGG
ATCCTATGAAGCCTGGAGGACCTTTCGAAGTGATGGCACAACAGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGT
TTGGAGATGTCTGGCTCTGTAGTGGGCAGAGTAACATGCAGATGACTGTGTTACAGATATTTAATGCTACAAGGGAGTTGTCTAACACTG
CGGCATATCAGTCTGTCCGCATCCTCTCTGTCTCTCCCATTCAAGCAGAGCAGGAGCTGGAGGACCTTGTTGCGGTTGACTTGCAGTGGT
CTAAGCCCACCTCAGAAAACTTAGGCCATGGATATTTCAAGTACATGTCAGCAGTGTGCTGGCTCTTTGGACGTCACCTTTATGACACTC
TGCAGTATCCCATCGGGCTGATCGCCTCCAGCTGGGGCGGGACACCCATTGAAGCCTGGTCATCTGGACGGTCACTGAAAGCCTGTGGGG
TCCCTAAACAAGGGTCCATTCCATACGATTCTGTAACTGGTCCCAGTAAGCACTCTGTTCTCTGGAATGCCATGATCCATCCACTGTGCA
ATATGACTCTGAAAGGGGTAGTATGGTACCAGGGGGAGTCCAATATAAATTATAACACGGATCTGTACAATTGCACATTCCCTGCACTCA
TCGAAGACTGGCGTGAAACCTTCCACCGTGGTTCCCAGGGGCAGACGGAGCGTTTCTTCCCATTTGGACTTGTCCAGTTATCTTCAGATT
TGTCTAAGAAGAGCTCAGACGATGGATTTCCCCAGATCCGTTGGCATCAAACAGCAGACTTCGGCTATGTCCCCAACCCAAAGATGCCCA
ATACTTTCATGGCTGTAGCTATGGATCTCTGTGATAGAGACTCGCCTTTTGGCAGCATCCACCCTCGAGATAAACAGACTGTGGCTTATC
GGCTGCATTTGGGGGCCCGTGCTCTGGCTTATGGTGAGAAGAATTTGACCTTTGAAGGACCACTGCCTGAGAAGATAGAACTCTTGGCTC
ACAAGGGGCTGCTCAATCTCACATATTACCAGCAAATCCAGGTGCAGAAAAAGGACAACAAGATATTTGAGATCTCCTGTTGCAGTGACC
ATCGATGCAAGTGGCTTCCAGCTTCTATGAACACCGTCTCCACCCAGTCCCTGACCCTGGCGATCGATTCTTGTCATGGCACTGTGGTTG
CTCTCCGCTATGCTTGGACCACGTGGCCTTGTGAATATAAGCAGTGTCCCCTATACCACCCCAGTAGTGCCCTGCCAGCCCCTCCCTTCA
TTGCTTTCATTACAGACCAGGGTCCTGGACATCAGAGCAATGTTGCTAAATGACTGTTTCAGTATGATCAGAACTTAGATATAAGGATGG
GTCCTTCAGATTTTAGCATTTAGGAGTTTCAATAATAACCATTGCTTTTAAAGGAAATTAATAGAAAGCCTCATTGAATGGCTTTCAGCT
AGCACATGGCTGTTTCTATATTCTGATGAGCCCAGGCTTATAGGTAACTTGAAATGCTTGCTTTTTGTTCCCTAGTTGGTCTAAGGGTCT
GTATTGGACTAATTCTGAACTACAGACAAATTGGACCTCAATGTCATTTACTTCCCTCATATTAATGGGAGTGAAATGTCTAATACTTTT
GCCCCTTTTTATCCAGAGTTGTGGGAATCTCAGGATTGGAAGAGATTTTAAAGGCCACATAGGCCAGCTAGTGTTCATGTGTTCTTTATA
AAATTTCTCCCATCCAAGTACTAACCAGGCCCGACCCTGCTTAGCTTCCGAGATCAGATGAGATCAGGCGCGTTCAGGGTGATATGGCCG
TAGACGTCTTTACAAAATTCCTGACAGGTGGTTACTGAATCTCTCTATGAACTTTCCATTCAAAACTTTCCAAGTTTTTCCTTATGTGGA
ACCGAAATCTTTCTTTCTCCCGTGAAACTTTACTACTATCAGATAATTGAAGACAGATCTCTTTGTATTCTCTTCAAGCCCAAACCAATT
CTGTTCCTTCAATCTAAATAGTGGTAATATGAATGTTTAAGAAATGAAATAAGAAACATGTGCAGGCACTTTGGAAGGTGCTAAGTGACT
GCCCTAAGGAATGAAAAGCAAGGGCCAGGTGGGAGTAGCCCAGCGAAGGCACTTGGGCTGCCAGGAACAGGAGGCGTGGGAAACTCTGGC
TTAGGAAAACATGAACACAGGGGCAACAGAGGCAAACTGTTGTTCGAGTTAAATATAAATCTCAGGCTCTTTAAAGGTAAAAGGTTTAAG
GATAATCCATTTGGAAGAAGAAAAGAGTGAGGCTGAAAGTAAAGCCACATGACAAGCATATAAAAAAAAATGCAGATGATACAAATATGA
AAGAGGCCTTCAGTGTTTGTTTATTAAGAATCTTAATGCAGTTTACTGATGGATTAAAAACAGCTAACATTGTCTGAAAATTATGTTACC
TATAAGAAGTTGGAAATAAATAAAAGCATAATCACTAGTGATGTGTATGTATTTATATCCACTTGCAAACTGTCCTTGAAGCATGTGAAA
AGGAGTAAGAATACTATCTATGGGTAGCTTTCCTCCCCTTAATGTGAAAAATGAGAACTAAAGCAAAAAGCATCACTCACTGTACATATA
CAATGTATTTTACGTAGTGTAAAAAATATGGTTTAGATAGTGAATATATTAATGAAATCATATGTAAATTTATTTTTAGTGGCTGAATAA
TTTAAAACATTATGTGGAATTCACTATGTTTCCCCCAATTTAGGAACTTTTTACTGTGTGAAAATGAAATTTATAATACTCTGTAGGGTG
AATGATGGTTTTTGCTTTAGTTCTACCCCTCTGTAGAGTTCCAAGGGGTTCTGGTGTAGCTCCAAACAGCAGGAATAACTTTGTCAGTGC
CAAGATTTTATTTAGTTAAAAAACAAAAAATCTACACACTTTACAAGGAACGTTGGCTCCCCTGAGGACTTCCTAGCATTCAACTCGTTC
AGTTAACCCCTATTGCCCATGCTTTGACCTCTCATGCATCTGGCCCCATAGAAACCATGAACCTTGTAACAGATTGATGCCTGAGAAAAA
GTCAATCTACCCGTCCACTCCTCCACTCCCAATACACATACCCCCATGGGCTGTTCTAATTCGGGGGCAGCCAGAGGTAGCCAAGAACTC
TAAGTCCAGATTCCTTTCACCTCCAGGAACCTAGAGTACATAGTGTGAAAAATACGGTTCAGGCAATGATTATGTTAATGACGCCATGCA
CATTCATTTTTAGTGGCTGAGTAATTTAAAACATGATGTGGGAATTCACTGCATTTCCCCAAATGTAAGAACTTTTTAGTTTTAAAATGA
AATTTATAGTCACTGTAGAAAATTTGGACACTAAAGTATAAGCAAGTAAAAATCACCCCCAAATTCATCATTCAGAGAAACACTATTTTG
CTGAACCATTCACTTGACTTGAGTTATATAATTTTATACAGTACATATTATTTTGTAATCTGTGTTTTTGACTTACTTACTTTACCAAAA
TAATTTTCTTATGTAAATAATAGAATATAGATTTAGAGTGTTTCAGTTTGTGGAAGCCTCATTTTATTTAACCAATTTCCTATTAATGGA
CATATAGATTTTTAACAATTTTCTACTATTAAAATAATACTGTAATGAATATCACATGCAAACATCATACCACACTCGTCCAGTTATTTC
TTAGGGTTCTTAACATGGAAGAGGATAAATATATATTTAAAATTTAGATATCTACAGCTTAACCCTCCCAAAGGATTAAACAACTTACAT
TCTCACCAAGGTAGTCCTTTTTTTGCCCTCACCCTCATTGACACTGGATGTTGTCAAATTTAAAAAAAATCCTTAACAATCTGATAGATG
AAAAGATAGTTTAAGTATACTAAGGCAGTGTTTTTCAAGGTGTTTTTGTTTTTGTTTTTGAGTTGGAGTTTTGCTCTGTTGCCCAGGCTG
GAGTGCAGTGGCGCGGTCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTTCCTGCCTCAGCCTCCCGAGTAGCTGGGAC
TACAGGCGCGTGCCACCACGCCTGGCTAATTTTTTGTATTTTTATTAGAGACCGACTTAGCCAGGATGGTCTCGATCTCCTGACCTCTTG
ATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCAGCTTTTCAAGTTTCTTAAATCCATGATCCATA
GTAAAAACATTTTACACATATCTTCATACAAGTATATGTATATGTGGTATACGTACACACTATAGTTGTATATGCATTATAGCTGAAAAA
CCAGTTCAACCTTTCTACATGTGGTATGTTCCAAAAATTTTAAATGTCTTTCTAAAATGAGGCTCTTTTAATACGGGTATTACTCAGGCT
GTAATAGTGGGAAAATATTTGTTATATGATAAAAGCAGCATATATCATTTCTGTGTAAATGCCAGTATGCTCAAGCCATTTATGCAGAGA
AAAAAAGAAAAACACTGCATTAACATTTTAAGCAGTCCCCTTCCCGATTTGCTATTATACAAAGTTTGTTTCTTTTACATTGTAAAGTGT
ATACAACTTATAAAAAGACTATACTCAAAATCATAAAATACCAGTTAACTTAGCTTCTCAGTTTACAGTGGCCAGTGTGGTGTGCTCTAA
ACACTGCTGCCTGATCCCTCCCTCTGCTGGTCAGATTTATTACTATAAAGTACCAATCCCATTTGTGTTGTCCTCAATTGGCAATTATGA
ATGGCAGTGCATTAACCATTCAATTCTCACCACTCCATCCCCATTCTTCTACTTCTGGGTCCTTTTGTCCCTCCCTTTCCAGACAGCCCT
TGGTAACCTGCTGCTGGGTAACTAAGGCATCCCACAGGTAGTGTTGAGGTGTTAGGTGATAGAGTAAACCTCTACCTTAATGCTATTAAC
AGGGTCCAAAAATCCAGTTGCATGGAACATGGAGTTATATTATTACATGGCTAATGAAAAGACAGGACTAAGTCTGTTATAGAGTATGGG
ACTAACCCCCAATTATATGTGAATTTGTGTTATCATATGGTTTCAGTGTACTGAGCTAAAAAGCACATTATCTGAGGTGCAATACAAAGG
TTAAAGAGGTTAAAGATCCCC

>3968_3968_1_ALDOA-SIAE_ALDOA_chr16_30081734_ENST00000566897_SIAE_chr11_124543777_ENST00000263593_length(amino acids)=590AA_BP=10
MPNKQLFKGEKKKKTTAAEKGRVQPSPEVAGGCEDCKRVESASPPPRPRPCREPTFPVLGGGQILASMVAPGLVLGLVLPLILWADRSAG
IGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLEKINFTLRVH
DVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSAVCWLFGRHL
YDTLQYPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINYNTDLYNCTF
PALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFGSIHPRDKQT
VAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSLTLAIDSCHG
TVVALRYAWTTWPCEYKQCPLYHPSSALPAPPFIAFITDQGPGHQSNVAK

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Fusion Gene PPI Analysis for ALDOA-SIAE

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ALDOA-SIAE

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ALDOA-SIAE

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ALDOA	C0272066	Glycogen Storage Disease XII	7	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	ALDOA	C0017919	Glycogen Storage Disease	3	GENOMICS_ENGLAND
Hgene	ALDOA	C0520572	Enzymopathy	2	GENOMICS_ENGLAND
Hgene	ALDOA	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	ALDOA	C0027626	Neoplasm Invasiveness	1	CTD_human
Hgene	ALDOA	C0027627	Neoplasm Metastasis	1	CTD_human
Hgene	ALDOA	C0151744	Myocardial Ischemia	1	CTD_human
Hgene	ALDOA	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Hgene	ALDOA	C0678222	Breast Carcinoma	1	CTD_human
Hgene	ALDOA	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	ALDOA	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	ALDOA	C4704874	Mammary Carcinoma, Human	1	CTD_human
Tgene		C3150797	AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6	1	UNIPROT

Fusion Gene Studies in Kim Lab

Fusion gene:ALDOA-SIAE (FusionGDB2 ID:HG226TG54414)

Fusion Gene Summary for ALDOA-SIAE

Fusion Gene ORF analysis for ALDOA-SIAE

Fusion Genomic Features for ALDOA-SIAE

Fusion Protein Features for ALDOA-SIAE

Fusion Gene Sequence for ALDOA-SIAE

Fusion Gene PPI Analysis for ALDOA-SIAE

Related Drugs for ALDOA-SIAE

Related Diseases for ALDOA-SIAE

Fusion Gene Studies
in Kim Lab