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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FHIT-HMGA2 (FusionGDB2 ID:HG2272TG8091)

Fusion Gene Summary for FHIT-HMGA2

check button Fusion gene summary
Fusion gene informationFusion gene name: FHIT-HMGA2
Fusion gene ID: hg2272tg8091
HgeneTgene
Gene symbol

FHIT

HMGA2

Gene ID

2272

8091

Gene namefragile histidine triad diadenosine triphosphatasehigh mobility group AT-hook 2
SynonymsAP3Aase|FRA3BBABL|HMGI-C|HMGIC|LIPO|STQTL9
Cytomap('FHIT')('HMGA2')

3p14.2

12q14.3

Type of geneprotein-codingprotein-coding
Descriptionbis(5'-adenosyl)-triphosphataseAP3A hydrolasediadenosine 5',5'''-P1,P3-triphosphate hydrolasedinucleosidetriphosphatasehigh mobility group protein HMGI-CHMGA2/KRT121P fusionhigh-mobility group (nonhistone chromosomal) protein isoform I-C
Modification date2020031320200329
UniProtAcc

P49789

P52926

Ensembl transtripts involved in fusion geneENST00000476844, ENST00000492590, 
ENST00000341848, ENST00000466788, 
ENST00000468189, 		ENST00000492590, 
ENST00000341848, ENST00000466788, 
ENST00000468189, ENST00000476844, 
Fusion gene scores* DoF score26 X 19 X 9=444616 X 12 X 5=960
# samples 2615
** MAII scorelog2(26/4446*10)=-4.09592441999854
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/960*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FHIT [Title/Abstract] AND HMGA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint
Anticipated loss of major functional domain due to fusion event.FHIT-HMGA2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
FHIT-HMGA2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FHIT-HMGA2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
FHIT-HMGA2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
FHIT-HMGA2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFHIT

GO:0006163

purine nucleotide metabolic process

9323207

TgeneHMGA2

GO:0000122

negative regulation of transcription by RNA polymerase II

14627817

TgeneHMGA2

GO:0002062

chondrocyte differentiation

21484705

TgeneHMGA2

GO:0006284

base-excision repair

19465398

TgeneHMGA2

GO:0007095

mitotic G2 DNA damage checkpoint

16061642

TgeneHMGA2

GO:0010564

regulation of cell cycle process

14645522

TgeneHMGA2

GO:0010628

positive regulation of gene expression

18832382

TgeneHMGA2

GO:0031052

chromosome breakage

19549901

TgeneHMGA2

GO:0031507

heterochromatin assembly

16901784

TgeneHMGA2

GO:0035978

histone H2A-S139 phosphorylation

16061642

TgeneHMGA2

GO:0035986

senescence-associated heterochromatin focus assembly

16901784

TgeneHMGA2

GO:0035988

chondrocyte proliferation

21484705

TgeneHMGA2

GO:0042769

DNA damage response, detection of DNA damage

19465398

TgeneHMGA2

GO:0043065

positive regulation of apoptotic process

16061642

TgeneHMGA2

GO:0043066

negative regulation of apoptotic process

19465398

TgeneHMGA2

GO:0043392

negative regulation of DNA binding

14645522

TgeneHMGA2

GO:0043922

negative regulation by host of viral transcription

17005673

TgeneHMGA2

GO:0045869

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

17005673

TgeneHMGA2

GO:0045892

negative regulation of transcription, DNA-templated

18832382

TgeneHMGA2

GO:0045893

positive regulation of transcription, DNA-templated

15225648|15755872|17005673|17324944|17426251

TgeneHMGA2

GO:0045944

positive regulation of transcription by RNA polymerase II

14645522|18832382

TgeneHMGA2

GO:0071158

positive regulation of cell cycle arrest

16061642

TgeneHMGA2

GO:0071902

positive regulation of protein serine/threonine kinase activity

19549901

TgeneHMGA2

GO:0090402

oncogene-induced cell senescence

16901784

TgeneHMGA2

GO:2000648

positive regulation of stem cell proliferation

21484705

TgeneHMGA2

GO:2000679

positive regulation of transcription regulatory region DNA binding

18832382

TgeneHMGA2

GO:2000685

positive regulation of cellular response to X-ray

16061642

TgeneHMGA2

GO:2001022

positive regulation of response to DNA damage stimulus

16061642|19465398

TgeneHMGA2

GO:2001033

negative regulation of double-strand break repair via nonhomologous end joining

19549901

TgeneHMGA2

GO:2001038

regulation of cellular response to drug

16061642



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..FHITchr3

59737946

-HMGA2chr12

66308838

+
ChimerKB3..FHITchr3

59737946

-HMGA2chr12

66345162

+


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Fusion Gene ORF analysis for FHIT-HMGA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000476844ENST00000393577FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-3CDSENST00000476844ENST00000403681FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-3CDSENST00000476844ENST00000541363FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-3CDSENST00000492590ENST00000393577FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-3CDSENST00000492590ENST00000403681FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-3CDSENST00000492590ENST00000541363FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-3UTRENST00000476844ENST00000354636FHITchr3

59737946

-HMGA2chr12

66308838

+
3UTR-3UTRENST00000476844ENST00000536545FHITchr3

59737946

-HMGA2chr12

66308838

+
3UTR-3UTRENST00000492590ENST00000354636FHITchr3

59737946

-HMGA2chr12

66308838

+
3UTR-3UTRENST00000492590ENST00000536545FHITchr3

59737946

-HMGA2chr12

66308838

+
3UTR-intronENST00000476844ENST00000354636FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-intronENST00000476844ENST00000393577FHITchr3

59737946

-HMGA2chr12

66308838

+
3UTR-intronENST00000476844ENST00000393578FHITchr3

59737946

-HMGA2chr12

66308838

+
3UTR-intronENST00000476844ENST00000393578FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-intronENST00000476844ENST00000403681FHITchr3

59737946

-HMGA2chr12

66308838

+
3UTR-intronENST00000476844ENST00000425208FHITchr3

59737946

-HMGA2chr12

66308838

+
3UTR-intronENST00000476844ENST00000425208FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-intronENST00000476844ENST00000536545FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-intronENST00000476844ENST00000541363FHITchr3

59737946

-HMGA2chr12

66308838

+
3UTR-intronENST00000492590ENST00000354636FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-intronENST00000492590ENST00000393577FHITchr3

59737946

-HMGA2chr12

66308838

+
3UTR-intronENST00000492590ENST00000393578FHITchr3

59737946

-HMGA2chr12

66308838

+
3UTR-intronENST00000492590ENST00000393578FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-intronENST00000492590ENST00000403681FHITchr3

59737946

-HMGA2chr12

66308838

+
3UTR-intronENST00000492590ENST00000425208FHITchr3

59737946

-HMGA2chr12

66308838

+
3UTR-intronENST00000492590ENST00000425208FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-intronENST00000492590ENST00000536545FHITchr3

59737946

-HMGA2chr12

66345162

+
3UTR-intronENST00000492590ENST00000541363FHITchr3

59737946

-HMGA2chr12

66308838

+
5CDS-3UTRENST00000341848ENST00000354636FHITchr3

59737946

-HMGA2chr12

66308838

+
5CDS-3UTRENST00000341848ENST00000536545FHITchr3

59737946

-HMGA2chr12

66308838

+
5CDS-intronENST00000341848ENST00000354636FHITchr3

59737946

-HMGA2chr12

66345162

+
5CDS-intronENST00000341848ENST00000393577FHITchr3

59737946

-HMGA2chr12

66308838

+
5CDS-intronENST00000341848ENST00000393578FHITchr3

59737946

-HMGA2chr12

66308838

+
5CDS-intronENST00000341848ENST00000393578FHITchr3

59737946

-HMGA2chr12

66345162

+
5CDS-intronENST00000341848ENST00000403681FHITchr3

59737946

-HMGA2chr12

66308838

+
5CDS-intronENST00000341848ENST00000425208FHITchr3

59737946

-HMGA2chr12

66308838

+
5CDS-intronENST00000341848ENST00000425208FHITchr3

59737946

-HMGA2chr12

66345162

+
5CDS-intronENST00000341848ENST00000536545FHITchr3

59737946

-HMGA2chr12

66345162

+
5CDS-intronENST00000341848ENST00000541363FHITchr3

59737946

-HMGA2chr12

66308838

+
Frame-shiftENST00000341848ENST00000541363FHITchr3

59737946

-HMGA2chr12

66345162

+
In-frameENST00000341848ENST00000393577FHITchr3

59737946

-HMGA2chr12

66345162

+
In-frameENST00000341848ENST00000403681FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-3CDSENST00000466788ENST00000393577FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-3CDSENST00000466788ENST00000403681FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-3CDSENST00000466788ENST00000541363FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-3CDSENST00000468189ENST00000393577FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-3CDSENST00000468189ENST00000403681FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-3CDSENST00000468189ENST00000541363FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-3UTRENST00000466788ENST00000354636FHITchr3

59737946

-HMGA2chr12

66308838

+
intron-3UTRENST00000466788ENST00000536545FHITchr3

59737946

-HMGA2chr12

66308838

+
intron-3UTRENST00000468189ENST00000354636FHITchr3

59737946

-HMGA2chr12

66308838

+
intron-3UTRENST00000468189ENST00000536545FHITchr3

59737946

-HMGA2chr12

66308838

+
intron-intronENST00000466788ENST00000354636FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-intronENST00000466788ENST00000393577FHITchr3

59737946

-HMGA2chr12

66308838

+
intron-intronENST00000466788ENST00000393578FHITchr3

59737946

-HMGA2chr12

66308838

+
intron-intronENST00000466788ENST00000393578FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-intronENST00000466788ENST00000403681FHITchr3

59737946

-HMGA2chr12

66308838

+
intron-intronENST00000466788ENST00000425208FHITchr3

59737946

-HMGA2chr12

66308838

+
intron-intronENST00000466788ENST00000425208FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-intronENST00000466788ENST00000536545FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-intronENST00000466788ENST00000541363FHITchr3

59737946

-HMGA2chr12

66308838

+
intron-intronENST00000468189ENST00000354636FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-intronENST00000468189ENST00000393577FHITchr3

59737946

-HMGA2chr12

66308838

+
intron-intronENST00000468189ENST00000393578FHITchr3

59737946

-HMGA2chr12

66308838

+
intron-intronENST00000468189ENST00000393578FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-intronENST00000468189ENST00000403681FHITchr3

59737946

-HMGA2chr12

66308838

+
intron-intronENST00000468189ENST00000425208FHITchr3

59737946

-HMGA2chr12

66308838

+
intron-intronENST00000468189ENST00000425208FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-intronENST00000468189ENST00000536545FHITchr3

59737946

-HMGA2chr12

66345162

+
intron-intronENST00000468189ENST00000541363FHITchr3

59737946

-HMGA2chr12

66308838

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341848FHITchr359737946-ENST00000403681HMGA2chr1266345162+35284440443147
ENST00000341848FHITchr359737946-ENST00000393577HMGA2chr1266345162+6584440443147

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FHIT-HMGA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for FHIT-HMGA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:/chr12:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FHIT

P49789

HMGA2

P52926

FUNCTION: Possesses dinucleoside triphosphate hydrolase activity (PubMed:12574506, PubMed:15182206, PubMed:8794732, PubMed:9323207, PubMed:9576908, PubMed:9543008). Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (PubMed:12574506, PubMed:15182206, PubMed:8794732, PubMed:9323207, PubMed:9576908, PubMed:9543008). Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP (PubMed:8794732). Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (PubMed:18694747). Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:18694747). Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate (PubMed:26181368). Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate (PubMed:26181368). Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (PubMed:18077326). Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways (PubMed:16407838). Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis (PubMed:15313915). Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake (PubMed:12574506, PubMed:19622739). Functions as tumor suppressor (By similarity). {ECO:0000250|UniProtKB:O89106, ECO:0000269|PubMed:12574506, ECO:0000269|PubMed:15313915, ECO:0000269|PubMed:16407838, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18694747, ECO:0000269|PubMed:19622739, ECO:0000269|PubMed:26181368, ECO:0000269|PubMed:8794732, ECO:0000269|PubMed:9323207, ECO:0000269|PubMed:9543008}.FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FHIT-HMGA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30354_30354_1_FHIT-HMGA2_FHIT_chr3_59737946_ENST00000341848_HMGA2_chr12_66345162_ENST00000393577_length(transcript)=658nt_BP=444nt
ATGTCGTTCAGATTTGGCCAACATCTCATCAAGCCCTCTGTAGTGTTTCTCAAAACAGAACTGTCCTTCGCTCTTGTGAATAGGAAACCT
GTGGTACCAGGACATGTCCTTGTGTGCCCGCTGCGGCCAGTGGAGCGCTTCCATGACCTGCGTCCTGATGAAGTGGCCGATTTGTTTCAG
ACGACCCAGAGAGTCGGGACAGTGGTGGAAAAACATTTCCATGGGACCTCTCTCACCTTTTCCATGCAGGATGGCCCCGAAGCCGGACAG
ACTGTGAAGCACGTTCACGTCCATGTTCTTCCCAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATCTATGAGGAGCTCCAGAAACAT
GACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACCACAA
CAAGTTGTTCAGAAGAAGCCTGCTCAGGTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAATCTTATATATCTACTGTTCTCTAAA
AATGCCACTTAGAAGAGAATTGAAACTTCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAAACAATTACATATGAGCTTTAAGTGG

>30354_30354_1_FHIT-HMGA2_FHIT_chr3_59737946_ENST00000341848_HMGA2_chr12_66345162_ENST00000393577_length(amino acids)=147AA_BP=
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQ

--------------------------------------------------------------
>30354_30354_2_FHIT-HMGA2_FHIT_chr3_59737946_ENST00000341848_HMGA2_chr12_66345162_ENST00000403681_length(transcript)=3528nt_BP=444nt
ATGTCGTTCAGATTTGGCCAACATCTCATCAAGCCCTCTGTAGTGTTTCTCAAAACAGAACTGTCCTTCGCTCTTGTGAATAGGAAACCT
GTGGTACCAGGACATGTCCTTGTGTGCCCGCTGCGGCCAGTGGAGCGCTTCCATGACCTGCGTCCTGATGAAGTGGCCGATTTGTTTCAG
ACGACCCAGAGAGTCGGGACAGTGGTGGAAAAACATTTCCATGGGACCTCTCTCACCTTTTCCATGCAGGATGGCCCCGAAGCCGGACAG
ACTGTGAAGCACGTTCACGTCCATGTTCTTCCCAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATCTATGAGGAGCTCCAGAAACAT
GACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACCACAA
CAAGTTGTTCAGAAGAAGCCTGCTCAGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAGGACTAGGGGGCGCCAACGTTC
GATTTCTACCTCAGCAGCAGTTGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTGTATTGCCATGGTCTTTCCACTTTC
ATCTGGGGTGGGGTGGGGTGGGGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTTAAAAAGGACTATATTAATCACCTTC
TTTGTAATCCCTTCACAGTCCCAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAACAATGCAACTTTTAATTACTGTTT
TCTTTTTTCTTAACCTACTAATAGTTTGTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAATTGGGTTTAGTCAATCACTGC
ACTGCATGCAAACAAGAAACGTGTCACACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGTAACACTGTGTACACCTCAAAT
ACCACCCCAACCCACTCCCTGTAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACTTTCTCTTTTTCGTATAATCTT
GTAGACACTTACTTGATGATTTTTAACTTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCATTCAGCTAACAAACTAGAAAA
GGTTATGTTCATTTTTCAAAAAGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATCACACATATCAGCAGGAGTAAT
AAATTTACTCACAGCACTTGTTTTCAGGACAACACTTCATTTTCAGGAAATCTACTTCCTACAGAGCCAAAATGCCATTTAGCAATAAAT
AACACTTGTCAGCCTCAGAGCATTTAAGGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTAATGAAAAGGTACAACAGAATAATGC
ATGATGAACTCACCTAATTATGAGGTGGGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATACATCAATTTAAAAAGCAAAAAAAAA
AAAGGGGGGGGCAATCTCTCTCTGTGTCTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTGTATCAGTTTCCATGAAAGACC
TGAATACCACTTACCTCAAATTAAGCATATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTGACCAAGGTGCTTTTCTTCGGC
TTGAGTTCACCATCTCTTCATTCAAACTGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAATACTACCTCTGAATGTTACAAC
GAATTTACAGTCTAGTACTTATTACATGCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTAGGTGATTCTAATCATCTGCAG
TTCTTTTTGTACACTTAATTACAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATTTTTCTATGTTTTTTTAATTAA
AAATTTTTAAAATACTTGTTTCAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAACCAAGTCGCTCCTAGGTTCTTAAGG
ATAATTTTCCTCAATCACACTACACATCACACAAGATTTGACTGTAATATTTAAATATTACCCTCCAAGTCTGTACCTCAAATGAATTCT
TTAAGGAGATGGACTAATTGACTTGCAAAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTTACTTGCAGCATTCATTTGTTTTTTC
AATGTTTGAAATAGTTCAAACTGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGATAGAAAGGAACACGTTTTTACATAC
TTTTGCAAAATAAGTAAATAATAAATAAAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGTGAGATGCAACAAGCCCTGCTT
TTGCATAATGCAATCAAAAATATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATTTTCATGTATTTTACACAAATG
TGATTTTTGTAATATGTCTCAACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCTCTCCTAGTGAGTGTGCTGACT
TTTTAACATGGTATTATCAACTGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTTAGTACTGAAGCCAAATGAAAC
TCAAAACCATCTCTCTTCCAGCTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGGCAGATCGCTCACTGTTGTGAA
TCACCAAAGGAGCTATGGAGAGAATTAAAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCAAATAAACAGTGGCTCATAAAAATAA
AAGTCGCATTCCATATCTTTGGATGGGCCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAAGCAATTGCTCATGTTGGCCAAACAT
GGTGCACCGAGTGATTTCCATCTCTGGTAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCAAAACACACTACTACCTCTTAAGTCC
CAGTATACCTCATTTTTCATACTGAAAAAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAATTTTTATATATATAGTTTATT
TTTGTGGGAGATAAATTTTATAGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACATTTAACTTTTCTACCATTTCTG
CAAGTTAGGTATGTTTGCAGGAGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCTTTGAGTGTCTTCTAACTTTAT
TCTTTGTTCTTTATGTAGAATTGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTCTCTAGTGTATTATCACTGTCT
GTTCTGCACAATAAACATAACAGCCTCTGTGATCCCCATGTGTTTTGATTCCTGCTCTTTGTTACAGTTCCATTAAATGAGTAATAAAGT

>30354_30354_2_FHIT-HMGA2_FHIT_chr3_59737946_ENST00000341848_HMGA2_chr12_66345162_ENST00000403681_length(amino acids)=147AA_BP=
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQ

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Fusion Gene PPI Analysis for FHIT-HMGA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FHIT-HMGA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FHIT-HMGA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFHITC0024121Lung Neoplasms2CTD_human
HgeneFHITC0025500Mesothelioma2CTD_human
HgeneFHITC0242379Malignant neoplasm of lung2CTD_human
HgeneFHITC0007097Carcinoma1CTD_human
HgeneFHITC0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneFHITC0013146Drug abuse1CTD_human
HgeneFHITC0013170Drug habituation1CTD_human
HgeneFHITC0013222Drug Use Disorders1CTD_human
HgeneFHITC0023903Liver neoplasms1CTD_human
HgeneFHITC0024623Malignant neoplasm of stomach1CTD_human
HgeneFHITC0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneFHITC0033578Prostatic Neoplasms1CTD_human
HgeneFHITC0038356Stomach Neoplasms1CTD_human
HgeneFHITC0038580Substance Dependence1CTD_human
HgeneFHITC0038586Substance Use Disorders1CTD_human
HgeneFHITC0042076Urologic Neoplasms1CTD_human
HgeneFHITC0205696Anaplastic carcinoma1CTD_human
HgeneFHITC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneFHITC0205698Undifferentiated carcinoma1CTD_human
HgeneFHITC0205699Carcinomatosis1CTD_human
HgeneFHITC0236733Amphetamine-Related Disorders1CTD_human
HgeneFHITC0236804Amphetamine Addiction1CTD_human
HgeneFHITC0236807Amphetamine Abuse1CTD_human
HgeneFHITC0236969Substance-Related Disorders1CTD_human
HgeneFHITC0345904Malignant neoplasm of liver1CTD_human
HgeneFHITC0376358Malignant neoplasm of prostate1CTD_human
HgeneFHITC0740858Substance abuse problem1CTD_human
HgeneFHITC0751571Cancer of Urinary Tract1CTD_human
HgeneFHITC1510472Drug Dependence1CTD_human
HgeneFHITC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneFHITC4316881Prescription Drug Abuse1CTD_human
TgeneC1519176Salivary Gland Pleomorphic Adenoma2ORPHANET
TgeneC0005612Birth Weight1CTD_human
TgeneC0006826Malignant Neoplasms1CTD_human
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC0027651Neoplasms1CTD_human
TgeneC0086692Benign Neoplasm1CTD_human
TgeneC0175693Russell-Silver syndrome1GENOMICS_ENGLAND
TgeneC0473935Radiolabeled somatostatin analog study1GENOMICS_ENGLAND
TgeneC0796160MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE1GENOMICS_ENGLAND
TgeneC1096309Myolipoma1GENOMICS_ENGLAND
TgeneC430514012q14 microdeletion syndrome1ORPHANET