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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CASC3-ADCY2 (FusionGDB2 ID:HG22794TG108)

Fusion Gene Summary for CASC3-ADCY2

check button Fusion gene summary
Fusion gene informationFusion gene name: CASC3-ADCY2
Fusion gene ID: hg22794tg108
HgeneTgene
Gene symbol

CASC3

ADCY2

Gene ID

22794

108

Gene nameCASC3 exon junction complex subunitadenylate cyclase 2
SynonymsBTZ|MLN51AC2|HBAC2
Cytomap('CASC3')('ADCY2')

17q21.1

5p15.31

Type of geneprotein-codingprotein-coding
Descriptionprotein CASC3MLN 51barentszcancer susceptibility 3cancer susceptibility candidate 3cancer susceptibility candidate gene 3 proteinmetastatic lymph node 51metastatic lymph node gene 51 proteinprotein barentszadenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264645, ENST00000264645, 
Fusion gene scores* DoF score21 X 10 X 10=21008 X 8 X 6=384
# samples 289
** MAII scorelog2(28/2100*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/384*10)=-2.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CASC3 [Title/Abstract] AND ADCY2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCASC3(38323114)-ADCY2(7414686), # samples:1
Anticipated loss of major functional domain due to fusion event.ADCY2-CASC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY2-CASC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CASC3-ADCY2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CASC3-ADCY2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CASC3-ADCY2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CASC3-ADCY2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCASC3

GO:0000398

mRNA splicing, via spliceosome

29301961


check buttonFusion gene breakpoints across CASC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ADCY2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-MA-AA43-01ACASC3chr17

38323114

+ADCY2chr5

7414686

+


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Fusion Gene ORF analysis for CASC3-ADCY2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264645ENST00000513693CASC3chr17

38323114

+ADCY2chr5

7414686

+
5CDS-intronENST00000264645ENST00000537121CASC3chr17

38323114

+ADCY2chr5

7414686

+
In-frameENST00000264645ENST00000338316CASC3chr17

38323114

+ADCY2chr5

7414686

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264645CASC3chr1738323114+ENST00000338316ADCY2chr57414686+8038176217248271551

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264645ENST00000338316CASC3chr1738323114+ADCY2chr57414686+0.0005316020.9994684

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Fusion Genomic Features for CASC3-ADCY2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CASC3chr1738323114+ADCY2chr57414685+3.55E-081
CASC3chr1738323114+ADCY2chr57414685+3.55E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CASC3-ADCY2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38323114/chr5:7414686)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASC3chr17:38323114chr5:7414686ENST00000264645+81495_1315121130.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneCASC3chr17:38323114chr5:7414686ENST00000264645+814392_3955121130.6666666666667Compositional biasNote=Poly-Pro
HgeneCASC3chr17:38323114chr5:7414686ENST00000264645+81441_465121130.6666666666667Compositional biasNote=Poly-Gly
HgeneCASC3chr17:38323114chr5:7414686ENST00000264645+814425_4285121130.6666666666667Compositional biasNote=Poly-Pro
HgeneCASC3chr17:38323114chr5:7414686ENST00000264645+814204_2105121130.6666666666667MotifNuclear localization signal 1
HgeneCASC3chr17:38323114chr5:7414686ENST00000264645+814254_2625121130.6666666666667MotifNuclear localization signal 2
HgeneCASC3chr17:38323114chr5:7414686ENST00000264645+814462_4665121130.6666666666667MotifNote=Nuclear export signal
HgeneCASC3chr17:38323114chr5:7414686ENST00000264645+814137_2835121130.6666666666667RegionNote=Sufficient to form the EJC
TgeneADCY2chr17:38323114chr5:7414686ENST000003383160251019_1021701092.0Nucleotide bindingATP
TgeneADCY2chr17:38323114chr5:7414686ENST000003383160251026_1030701092.0Nucleotide bindingATP
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025295_300701092.0Nucleotide bindingATP
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025337_339701092.0Nucleotide bindingATP
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025208_601701092.0Topological domainCytoplasmic
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025822_1091701092.0Topological domainCytoplasmic
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025108_128701092.0TransmembraneHelical
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025133_153701092.0TransmembraneHelical
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025159_179701092.0TransmembraneHelical
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025187_207701092.0TransmembraneHelical
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025602_622701092.0TransmembraneHelical
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025628_652701092.0TransmembraneHelical
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025680_701701092.0TransmembraneHelical
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025734_755701092.0TransmembraneHelical
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025763_780701092.0TransmembraneHelical
TgeneADCY2chr17:38323114chr5:7414686ENST0000033831602576_96701092.0TransmembraneHelical
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025801_821701092.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASC3chr17:38323114chr5:7414686ENST00000264645+814643_6485121130.6666666666667Compositional biasNote=Poly-Pro
HgeneCASC3chr17:38323114chr5:7414686ENST00000264645+814692_6955121130.6666666666667Compositional biasNote=Poly-Pro
HgeneCASC3chr17:38323114chr5:7414686ENST00000264645+814377_7035121130.6666666666667RegionNote=Necessary for localization in cytoplasmic stress granules
TgeneADCY2chr17:38323114chr5:7414686ENST000003383160251_45701092.0Topological domainCytoplasmic
TgeneADCY2chr17:38323114chr5:7414686ENST0000033831602546_66701092.0TransmembraneHelical


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Fusion Gene Sequence for CASC3-ADCY2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13142_13142_1_CASC3-ADCY2_CASC3_chr17_38323114_ENST00000264645_ADCY2_chr5_7414686_ENST00000338316_length(transcript)=8038nt_BP=1762nt
CACACACACACACACACACACACACACCCCAACACACACACACACACCCCAACACACACACACACACACACACACACACACACACACACA
CACACACACACACACACAGCGGGATGGCCGAGCGCCGCACGCGTAGCACGCCGGGACTAGCTATCCAGCCTCCCAGCAGCCTCTGCGACG
GGCGCGGTGCGTAAGTACCTCGCCGGTGGTGGCCGTTCTCCGTAAGATGGCGGACCGGCGGCGGCAGCGCGCTTCGCAAGACACCGAGGA
CGAGGAATCTGGTGCTTCGGGCTCCGACAGCGGCGGCTCCCCGTTGCGGGGAGGCGGGAGCTGCAGCGGTAGCGCCGGAGGCGGCGGCAG
CGGCTCTCTGCCTTCACAGCGCGGAGGCCGAACCGGGGCCCTTCATCTGCGGCGGGTGGAGAGCGGGGGCGCCAAGAGTGCTGAGGAGTC
GGAGTGTGAGAGTGAAGATGGCATTGAAGGTGATGCTGTTCTCTCGGATTATGAAAGTGCAGAAGACTCGGAAGGTGAAGAAGGTGAATA
CAGTGAAGAGGAAAACTCCAAAGTGGAGCTGAAATCAGAAGCTAATGATGCTGTTAATTCTTCAACAAAAGAAGAGAAGGGAGAAGAAAA
GCCTGACACCAAAAGCACTGTGACTGGAGAGAGGCAAAGTGGGGACGGACAGGAGAGCACAGAGCCTGTGGAGAACAAAGTGGGTAAAAA
GGGCCCTAAGCATTTGGATGATGATGAAGATCGGAAGAATCCAGCATACATACCTCGGAAAGGGCTCTTCTTTGAGCATGATCTTCGAGG
GCAAACTCAGGAGGAGGAAGTCAGACCCAAGGGGCGTCAGCGAAAGCTATGGAAGGATGAGGGTCGCTGGGAGCATGACAAGTTCCGGGA
AGATGAGCAGGCCCCAAAGTCCCGACAGGAGCTCATTGCTCTTTATGGTTATGACATTCGCTCAGCTCATAATCCTGATGACATCAAACC
TCGAAGAATCCGGAAACCCCGATATGGGAGTCCTCCACAAAGAGATCCAAACTGGAACGGTGAGCGGCTAAACAAGTCTCATCGCCACCA
GGGTCTTGGGGGCACCCTACCACCAAGGACATTTATTAACAGGAATGCTGCAGGTACCGGCCGTATGTCTGCACCCAGGAATTATTCTCG
ATCTGGGGGCTTCAAGGAAGGTCGTGCTGGTTTTAGGCCTGTGGAAGCTGGTGGGCAGCATGGTGGCCGGTCTGGTGAGACTGTTAAGCA
TGAGATTAGTTACCGGTCACGGCGCCTAGAGCAGACTTCTGTGAGGGATCCATCTCCAGAAGCAGATGCTCCAGTGCTTGGCAGTCCTGA
GAAGGAAGAGGCAGCCTCAGAGCCACCAGCTGCTGCTCCTGATGCTGCACCACCACCCCCTGATAGGCCCATTGAGAAGAAATCCTATTC
CCGGGCAAGAAGAACTCGAACCAAAGTTGGAGATGCAGTCAAGCTTGCAGAGGAGGTGCCCCCTCCTCCTGAAGGACTGATTCCAGCACC
TCCAGTCCCAGAAACCACCCCAACTCCACCTACTAAGACTGGGACCTGGGAAGCTCCGGTGGATTCTAGTACAAGTGGACTTGAGCAAGA
TGTGGCACAACTAAATATAGCAGAACAGAATTGGAGTCCGGGGCAGCCTTCTTTCCTGCAACCACGGGAACTTCGAGGTATGCCCAACCA
TATACACATGGGAGCAGGACCTCCACCTCAGTTTAACCGGATGGAAGAAATGGAAGTTGAAGACCATGTGGCGTTTCTAATAACAGTTCC
AACTGCCCTGGCGATTTTCTTTGCGATATTTATCCTGGTCTGCATCGAGTCTGTGTTTAAGAAGCTGCTGCGCCTCTTCTCGTTGGTGAT
ATGGATATGCCTTGTTGCCATGGGATACCTGTTCATGTGTTTTGGAGGCACCGTCTCTCCCTGGGACCAGGTATCGTTCTTCCTCTTCAT
CATCTTCGTGGTGTACACCATGCTGCCCTTCAACATGCGAGACGCCATCATTGCCAGCGTCCTCACCTCCTCCTCCCACACCATCGTGCT
TAGCGTCTGCCTGTCTGCAACACCGGGAGGCAAGGAGCACCTGGTCTGGCAGATCCTGGCCAATGTGATCATTTTCATCTGTGGGAACCT
GGCGGGAGCCTACCATAAGCACCTCATGGAACTCGCTCTTCAGCAAACATATCAGGACACCTGTAATTGCATCAAGTCGCGGATCAAGTT
GGAATTTGAAAAACGTCAACAGGAGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAG
GCTGCAGGGCCCCAAGGCGGGCCAGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATA
CGCTGACATCGTTGGCTTTACCCGGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGA
TCAAATTGCAAAGGAGAATGAATGCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAA
CCATGCCAAGAACTGTGTGAAAATGGGGCTGGACATGTGTGAAGCCATAAAGAAAGTGAGGGATGCTACTGGAGTTGATATCAACATGCG
CGTGGGCGTGCATTCTGGGAATGTCCTGTGTGGCGTGATTGGTCTGCAGAAGTGGCAATATGATGTGTGGTCACATGATGTGACCTTGGC
CAACCACATGGAAGCTGGAGGGGTCCCTGGACGTGTTCACATTTCTTCTGTCACCCTGGAGCACTTGAATGGCGCTTATAAAGTGGAGGA
GGGAGATGGTGACATTAGGGACCCATATTTAAAACAGCACCTGGTGAAAACCTACTTTGTGATCAACCCCAAGGGAGAACGACGGAGCCC
CCAGCATCTCTTCAGACCTCGCCACACCCTTGATGGAGCCAAAATGAGGGCCTCGGTCCGCATGACCCGGTACTTGGAGTCCTGGGGGGC
AGCCAAGCCCTTTGCACACCTACATCACAGGGACAGCATGACCACAGAGAACGGCAAGATCAGCACCACGGATGTACCCATGGGTCAGCA
TAATTTTCAAAATCGCACCTTAAGAACCAAGTCACAAAAGAAGAGATTTGAAGAAGAATTGAATGAAAGGATGATTCAAGCAATTGATGG
GATTAATGCACAGAAGCAATGGCTCAAGTCTGAAGACATTCAGAGAATCTCACTGCTTTTCTATAACAAAGTACTAGAAAAAGAGTACCG
GGCCACGGCACTGCCAGCGTTCAAGTATTATGTGACTTGTGCCTGTCTCATATTCTTCTGCATCTTCATTGTGCAGATTCTCGTGCTGCC
AAAAACGTCCGTCCTGGGCATCTCCTTTGGGGCTGCGTTTCTCTTGCTGGCCTTCATCCTCTTCGTCTGCTTTGCTGGACAGCTTCTGCA
ATGCAGCAAAAAAGCCTCTCCCCTGCTCATGTGGCTTTTGAAGTCCTCGGGCATCATTGCCAACCGCCCCTGGCCACGGATCTCTCTCAC
GATCATCACCACAGCCATCATATTAATGATGGCCGTGTTCAACATGTTTTTCCTGAGTGACTCAGAGGAAACAATCCCTCCAACTGCCAA
CACAACAAACACAAGCTTTTCAGCCTCAAATAATCAGGTGGCGATTCTGCGTGCGCAGAATTTATTTTTCCTCCCGTACTTTATCTACAG
CTGCATTCTGGGACTGATATCCTGTTCCGTGTTCCTGCGGGTAAACTATGAGCTGAAGATGTTGATCATGATGGTGGCCTTGGTGGGCTA
CAACACCATCCTACTCCACACCCACGCCCACGTCCTGGGCGACTACAGCCAGGTCTTATTTGAGAGACCAGGCATTTGGAAAGACCTGAA
GACCATGGGCTCTGTGTCTCTCTCTATATTCTTCATCACACTGCTTGTTCTGGGTAGACAGAATGAATATTACTGTAGGTTAGACTTCTT
ATGGAAGAACAAATTCAAAAAAGAGCGGGAGGAGATAGAGACCATGGAGAACCTGAACCGCGTGCTGCTGGAGAACGTGCTTCCCGCGCA
CGTGGCTGAGCACTTCCTGGCCAGGAGCCTGAAGAATGAGGAGCTATACCACCAGTCCTATGACTGCGTCTGCGTCATGTTTGCCTCCAT
TCCGGATTTCAAAGAATTTTATACAGAATCCGACGTGAACAAGGAGGGCTTGGAATGCCTTCGGCTCCTGAACGAGATCATCGCTGACTT
TGATGATCTTCTTTCCAAGCCAAAATTCAGTGGAGTTGAAAAGATTAAGACCATTGGCAGCACATACATGGCAGCAACAGGTCTGAGCGC
TGTGCCCAGCCAGGAGCACTCCCAGGAGCCCGAGCGGCAGTACATGCACATTGGCACCATGGTGGAGTTTGCTTTTGCCCTGGTAGGGAA
GCTGGATGCCATCAACAAGCACTCCTTCAACGACTTCAAATTGCGAGTGGGTATTAACCATGGACCTGTGATAGCTGGTGTGATTGGAGC
TCAGAAGCCACAATATGATATCTGGGGCAACACTGTCAATGTGGCCAGTAGGATGGACAGCACCGGAGTCCTGGACAAAATACAGGTTAC
CGAGGAGACGAGCCTCGTCCTGCAGACCCTCGGATACACGTGCACCTGTCGAGGAATAATCAACGTGAAAGGAAAGGGGGACCTGAAGAC
GTACTTTGTAAACACAGAAATGTCAAGGTCCCTTTCCCAGAGCAACGTGGCATCCTGAAGAGTCACCTTCATTTTGGCAAGAAGACTGTA
TTTTCAGGAAGGTATCACACACTTTCTGACTGCAACTTCTGTCCCTTGTTTTTGATGTGCGTGCTGTCTGTCCTATGGAGCCTCTGCAGA
CTCGTTCTCGTGACCCAGTGGCATACCGTTTGGTGTCTGATGTGTGCCCAGATCGTTCTGCCACTTGCACTGTGCTTGCTCCTAAGCAAA
AGGGAAAAGGAGCGCGCGTGATAGAAGAAAAGCACTGGGAGAACTAACAGAGGAGAAAGGTGAAACACACACACATTCTTAAGGCAATAA
AACTAGGGGGTGTATATTATCTTCTGGTGCATGTTCTTTTCTGGAAAATATGGTAGCTCGCCAACCGCATCTGCTCATCTGATATTCAAA
CACACAGTATTCGTGAATAAGTTGATTCTGTCCCCCACGTGGACTCTGTGCTCACCCATTGTCTCATTGCCAGTGGTGTCCAAGGGCCCC
CGTTGGGACCCACGGCTCTCGTCCCTCTGCTCCGTGTGTCTCATGCCAGCAGCACGTCGCCATCCGTCACCAGAATTAGTCCTCACAGCC
TAGGACCAGTTTTGTATCAAACTCGTCTGATGTTTTGATGCCATTTGTCTTTTGTAAAGTTAATTCATTAAAAGTTTTATGTACTTTGAT
TTACAGTGCCTGTATCTTTTATTTTCCTGTCTTCTTTCTCCTGTGGTTTGCTCCAGAATTAAGGTTTGTTTTCCATCCATTCTCCCTTTT
GACACAGTTGTTTCAGAAAGAGCTCTCCAGAAGCCAATATTGAGATGTAATTCAGATTAGGACACAGTGTGTGACGCAGATAACTGGTTA
CTCAGCTCCCTGGAAAGCAGGCAAGCATGTTGAATGTATCTAGTGGTCTGATTTTAATTTGGGCATCTCTAGAGAACGCTTTCAGGGAAA
AATACTTTAATAGTAAAAAGATTCTCTGCGAGCAACAGTGCCCCCTCCGTCCACTACGCTCCTGTCTCCAAGAATGTTTTGCTAGAGCTA
ACAGACATAGACTGCAAAAGAATAATTTGGAATCAGCTATGCAAATCAGTCTCACAATAGCGTGAGCTAACTGAGAGAAGTACTAAGACC
CACAAACTGCCTGTTAAGTCTGAGAAGGCTAAAGAAGACACACAGCCAACGTTCATGCATTTTTAAAGACAGAAGGCCTTGAAGAATTTG
TTCTTGTAAATCCAACACAAGTTGTTTGGTACTTTTAACATAAAGAAATCATACTTTGCCAAATAGTGAAAAGTAGAGCAATCGTGTATA
AGCTAATGTTTAAAAGCAAAACTGCAAATTGTAGCCCAGTTGGTCAAACTTGTTTTCTTTTTATAACTCATGGCAGGCATCTGTAAGAAG
TAGAGAACCCAGATGATCTCTTAGGAAGCCTTTTATTCGTGGGAACTCGAACTTGAAGCACAAGTTCCTGGTTTGAATCCTGGCTCTGAT
TTTTTACTGGCTGTGTGACTTTGAACACATCTCTTAGTCCCTCTTAGGAGTACTTTCCTTATTGGCAACTTATGGACTCGCTAGTGATTA
AACGAGGCAATGACTGTGAGCGAGCCTGGCAGGTGCCCCGTGGTACATTCACAGCACGGGCACAGCTGCTGTGCCAGGACTGTGACTCAT
TCCCAGTAAAAGGCACTTATCGAAGCTGATAACCGTCCTTCATCACCGAAGTGTGAGTAGAGCATGACTTATTTAGTATTCTGCCTCAAT
GGGGAATTTTTTGATCCTGTAATCACAACTCAGCATTGGCCTTAATATACCTAAATCTCCAAAAACAGTGATTAAAGCAAGAGAATTATT
ACAAGGGCTTTTCTCTTTCCTCTAACTCATTCTTCACGGATGCCGTAGCGTTTCCGTGAGCTCAAACTGGCCTTGGTGTAAAATGTGTAA
GGATGAGCAGCAGGCGTGCCTCGTGGGTTCTTCCTCTGTTACATCCTGCTACACTCATCCGCAGGTCACCTTAGTTCACCTACCCTGAGT
GAACACCCCCAGCTGGGTGGTCCACCAAGTTCTCATAAACAGAGTCCCTCCCATTCCCCCACGGGGTGCACCGAACTTGGGTTTGCGCTA
AAAAGAACTCAAAAGGAGAACTGTGCTCTCCCAAAGCCATATCACCAGTCTTACCAAACAATAGGCTTTTAAAAGCATTGAGTCATTGTC
AGAATCCACTATGGGAAGCTCTGTGTGTACCTGGTCCCTTCTAGGTGTGGTCCCATAGGAGCAGCCTTAGCATCCCCTGTGAACTTATCA
AAAATGCAAATTCTCAGGCCCCAACCTGAAGGAGGACCCTGAATTTGAGATCCCCGGGGCTGGGGCCCAGCACAACTGCTGTTTAGTGAA
CAGGTTCTCCAGGTGATTCTGATCCCTGATCAAGCTTCAGACCTCCCTCCCTCCCCAGTGTTTTTGCAGGTGAGGAAACAGGGGCAGAGT
AATTCAGGCACATGTGTTCAGAGTTCCACAGTTGATTAGCAGTTGAGGCCAGGCTAGAATGGAAAACTGCCTGTTCCTTGAATCTGAAAG
AGCATTATTCCTGGTCAAAGCTCCTTAAAGTTCTGGGCAGCTAAAAGCATCCCTGTGAGCAAAAATGCCAGGCAGAAAACTGGCAGTGCA
CCTCTCATCAGCCCAGGTCCCAGTGCCATTGGCTTCAAGAAAAAAAAAAAATCTCTCCCCAATGCTCTCCTTAACCTTTAAGTCTTACAG
GAAGCCTCTCATAGAAATTGCCTCCAGTCCAGTTTCCCAAAAACCCCAGTGTTTTACATATCTGTTTAGGAGTGTCTAAGTTTTGTCATC
AATCCAGGATGTTATTCTTCCTTCCCAACTCACTGTGCTCCTAAAGGCAGCAACCATTCATCTTTCCTTTGCTCTGGATACACCGAATGA
CCAGGTAACATCATCAGGCCGGGTGCAGTGGCTCCTATAATCCCAATATTTTGGGAGGCCGAGGAGAGAGGATCACTTAAGCCCAGGAGT
CTGAGACCAGCCTGGGCAACATAGCAAGACCCCCATCTCTGCAAAAAAATAAGAAAATTAGCTTGGCATGGTGGCACGTGCCTGTAGTCC
CAGCTACATGGGAGGCTGAGGTGGGAGGATCACTTGAGCCCAGGAAGTCCAGAACGTAGTGAGCCTTGATTATACCACTGCACTCCAGCC
TGGGTGACAGAGCGAGACTCTGTCTCAG

>13142_13142_1_CASC3-ADCY2_CASC3_chr17_38323114_ENST00000264645_ADCY2_chr5_7414686_ENST00000338316_length(amino acids)=1551AA_BP=530
MRRARCVSTSPVVAVLRKMADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSA
EESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKV
GKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDD
IKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGET
VKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLI
PAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMEVEDHVAFLI
TVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHT
IVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEI
IQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPIS
LPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYK
VEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPM
GQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQIL
VLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPP
TANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWK
DLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMF
ASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFAL
VGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGD
LKTYFVNTEMSRSLSQSNVAS

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Fusion Gene PPI Analysis for CASC3-ADCY2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025905_92270.01092.0GNAS
TgeneADCY2chr17:38323114chr5:7414686ENST00000338316025990_99370.01092.0GNAS


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CASC3-ADCY2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CASC3-ADCY2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0005586Bipolar Disorder2CTD_human;PSYGENET
TgeneC0004096Asthma1CTD_human
TgeneC0005587Depression, Bipolar1CTD_human
TgeneC0024713Manic Disorder1CTD_human
TgeneC0338831Manic1CTD_human