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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:COPZ1-C19orf18 (FusionGDB2 ID:HG22818TG147685)

Fusion Gene Summary for COPZ1-C19orf18

Fusion gene summary

Fusion gene information	Fusion gene name: COPZ1-C19orf18
	Fusion gene ID: hg22818tg147685
		Hgene	Tgene
	Gene symbol	COPZ1	C19orf18
	Gene ID	22818	147685
	Gene name	COPI coat complex subunit zeta 1	chromosome 19 open reading frame 18
	Synonyms	CGI-120\|COPZ\|HSPC181\|zeta-COP\|zeta1-COP	-
	Cytomap	('COPZ1')('C19orf18') 12q13.13	19q13.43
	Type of gene	protein-coding	protein-coding
	Description	coatomer subunit zeta-1coatomer protein complex subunit zeta 1coatomer protein complex, subunit zetazeta-1 COPzeta-1-coat protein	uncharacterized protein C19orf18
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000548281, ENST00000262061, ENST00000416254, ENST00000455864, ENST00000548753, ENST00000549043, ENST00000549116, ENST00000551779, ENST00000552218, ENST00000552362, ENST00000553231,
Fusion gene scores	* DoF score	12 X 4 X 10=480	4 X 4 X 4=64
	# samples	13	5
	** MAII score	log2(13/480*10)=-1.88452278258006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: COPZ1 [Title/Abstract] AND C19orf18 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	COPZ1(54741628)-C19orf18(58472919), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	COPZ1	GO:0006891	intra-Golgi vesicle-mediated transport	11056392

Fusion gene breakpoints across COPZ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C19orf18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-FE-A235-01A	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-

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Fusion Gene ORF analysis for COPZ1-C19orf18

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000548281	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-
In-frame	ENST00000262061	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-
In-frame	ENST00000416254	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-
In-frame	ENST00000455864	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-
In-frame	ENST00000548753	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-
In-frame	ENST00000549043	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-
In-frame	ENST00000549116	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-
In-frame	ENST00000551779	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-
In-frame	ENST00000552218	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-
In-frame	ENST00000552362	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-
In-frame	ENST00000553231	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262061	COPZ1	chr12	54741628	+	ENST00000314391	C19orf18	chr19	58472919	-	874	432	25	708	227
ENST00000549043	COPZ1	chr12	54741628	+	ENST00000314391	C19orf18	chr19	58472919	-	956	514	95	790	231
ENST00000552218	COPZ1	chr12	54741628	+	ENST00000314391	C19orf18	chr19	58472919	-	933	491	21	767	248
ENST00000553231	COPZ1	chr12	54741628	+	ENST00000314391	C19orf18	chr19	58472919	-	793	351	13	627	204
ENST00000552362	COPZ1	chr12	54741628	+	ENST00000314391	C19orf18	chr19	58472919	-	862	420	13	696	227
ENST00000455864	COPZ1	chr12	54741628	+	ENST00000314391	C19orf18	chr19	58472919	-	793	351	13	627	204
ENST00000416254	COPZ1	chr12	54741628	+	ENST00000314391	C19orf18	chr19	58472919	-	770	328	86	604	172
ENST00000549116	COPZ1	chr12	54741628	+	ENST00000314391	C19orf18	chr19	58472919	-	683	241	8	517	169
ENST00000551779	COPZ1	chr12	54741628	+	ENST00000314391	C19orf18	chr19	58472919	-	850	408	1	684	227
ENST00000548753	COPZ1	chr12	54741628	+	ENST00000314391	C19orf18	chr19	58472919	-	918	476	108	752	214

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262061	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-	0.001052941	0.9989471
ENST00000549043	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-	0.002118667	0.99788135
ENST00000552218	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-	0.003066138	0.9969338
ENST00000553231	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-	0.002193907	0.99780613
ENST00000552362	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-	0.001155024	0.998845
ENST00000455864	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-	0.002193907	0.99780613
ENST00000416254	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-	0.007384641	0.99261534
ENST00000549116	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-	0.003378084	0.99662197
ENST00000551779	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-	0.001005289	0.99899477
ENST00000548753	ENST00000314391	COPZ1	chr12	54741628	+	C19orf18	chr19	58472919	-	0.005706738	0.99429333

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Fusion Genomic Features for COPZ1-C19orf18

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for COPZ1-C19orf18

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:54741628/chr19:58472919)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

C19orf18

chr12:54741628

chr19:58472919

ENST00000314391

122_215

123

216.0

Topological domain

Cytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

C19orf18

chr12:54741628

chr19:58472919

ENST00000314391

30_100

123

216.0

Topological domain

Extracellular

Tgene

C19orf18

chr12:54741628

chr19:58472919

ENST00000314391

101_121

123

216.0

Transmembrane

Helical

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Fusion Gene Sequence for COPZ1-C19orf18

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>18666_18666_1_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000262061_C19orf18_chr19_58472919_ENST00000314391_length(transcript)=874nt_BP=432nt
TTTTGCGGCTCCACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGAT
TCTGGACAATGATGGAGATCGACTTTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACAT
TTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTA
TGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAA
TGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGA
GGAAAGACAACAGCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTC
CACGCACCTACTTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAA
ACTGAAGGAAGAGCAAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGAC
AGAGGTGCCGGCTGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAA

>18666_18666_1_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000262061_C19orf18_chr19_58472919_ENST00000314391_length(amino acids)=227AA_BP=136
MRGKMEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYEN
ELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLLPENE

--------------------------------------------------------------
>18666_18666_2_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000416254_C19orf18_chr19_58472919_ENST00000314391_length(transcript)=770nt_BP=328nt
ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGA
TGGAGATCGACTTTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGAC
CCATCGGACTGACACTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGAG
CACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGC
TCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTC
CAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGC
AAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGCCGGCTG
AGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACATCAAAGA

>18666_18666_2_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000416254_C19orf18_chr19_58472919_ENST00000314391_length(amino acids)=172AA_BP=81
MMEIDFLPSTMTTPTPVSRSKRPLRRTFSTRPIGLTLMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQ

--------------------------------------------------------------
>18666_18666_3_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000455864_C19orf18_chr19_58472919_ENST00000314391_length(transcript)=793nt_BP=351nt
ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGA
GAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCT
CTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCT
GAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGC
ACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGA
GGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATAT
TAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAAC
GCAGACGACAGAGGTGCCGGCTGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAAC

>18666_18666_3_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000455864_C19orf18_chr19_58472919_ENST00000314391_length(amino acids)=204AA_BP=113
MRGKMEALILYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNV
EKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLLPENENELEKFIHSVIISKRSKNIKKKL

--------------------------------------------------------------
>18666_18666_4_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000548753_C19orf18_chr19_58472919_ENST00000314391_length(transcript)=918nt_BP=476nt
TGATGGTTTCCCAAGTTTGACTCTCCATTGCCGATTCCCTGCCACATTCCTTCAGGAAACTGTTTTGTCTTCGGTTTCCTGTTAATCCCT
ATTATATAGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGATGGAGATCGACTTTTTGCCAAGTACTATGACGAC
ACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAA
GGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTT
CTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTG
GCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAGAACCTCAGGATACCG
TTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATC
CACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAAAACAAAACAAAGAAT
GCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGCCGGCTGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAG
ACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACATCAAAGAAAGAAATGCCAGACCTGTATCCCAGAAAATAA

>18666_18666_4_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000548753_C19orf18_chr19_58472919_ENST00000314391_length(amino acids)=214AA_BP=123
MYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFD
SLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLLPENENELEKFIHSVIIS

--------------------------------------------------------------
>18666_18666_5_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000549043_C19orf18_chr19_58472919_ENST00000314391_length(transcript)=956nt_BP=514nt
TTGCGGCTCCACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGCCCCAGTGGGACTAGGGGAAGGTATCTGGTTTACCAG
TGGTGATGGGAGGCTTCAGGACTGAAGGTATGTTCGTATCTCTTCAGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACA
ATGATGGAGATCGACTTTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACA
AGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTG
GCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAA
AGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGAC
AACAGCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACC
TACTTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGG
AAGAGCAAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGC
CGGCTGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACAT

>18666_18666_5_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000549043_C19orf18_chr19_58472919_ENST00000314391_length(amino acids)=231AA_BP=140
MGGFRTEGMFVSLQEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGS
SYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLL

--------------------------------------------------------------
>18666_18666_6_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000549116_C19orf18_chr19_58472919_ENST00000314391_length(transcript)=683nt_BP=241nt
GGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGATGGAG
ATCGACTTTTTGCCAAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGC
GAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAAC
AGCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTAC
TTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAG
AGCAAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGCCGG
CTGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACATCAA

>18666_18666_6_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000549116_C19orf18_chr19_58472919_ENST00000314391_length(amino acids)=169AA_BP=78
MRGKMEALILEPSLYTVKAILILDNDGDRLFAKLMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLE

--------------------------------------------------------------
>18666_18666_7_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000551779_C19orf18_chr19_58472919_ENST00000314391_length(transcript)=850nt_BP=408nt
GCTGCGGGGCAAGATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGATGGAGATCGACT
TTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGACCCATCGGACTGA
CAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTGGCAGCTCCTATGAAAA
TGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGA
GAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTCGAGTCACT
TTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCAGAGAACGA
AAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAAAACTCAGT
AACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGCCGGCTGAGGCAGAGGA
GAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACATCAAAGAAAGAAATGCC

>18666_18666_7_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000551779_C19orf18_chr19_58472919_ENST00000314391_length(amino acids)=227AA_BP=136
LRGKMEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYEN
ELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLLPENE

--------------------------------------------------------------
>18666_18666_8_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000552218_C19orf18_chr19_58472919_ENST00000314391_length(transcript)=933nt_BP=491nt
GCGGCTCCACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTG
GACAATGATGGAGATCGACTTTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTC
AACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTG
ATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGAACAGGAAGC
ACCCAGGCAGGAGGACTGCATGAGTCGAGTTCAAGACAAGCTTGGGCAACACAGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATG
GAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAG
AACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAG
CTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAA
AACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGCCGGCTGAGGCAGAGGAGAAACTA
TGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACATCAAAGAAAGAAATGCCAGACCTG

>18666_18666_8_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000552218_C19orf18_chr19_58472919_ENST00000314391_length(amino acids)=248AA_BP=122
MRGKMEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYEN
ELMLMAVLNCLFDSLSQMLRTGSTQAGGLHESSSRQAWATQKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLL

--------------------------------------------------------------
>18666_18666_9_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000552362_C19orf18_chr19_58472919_ENST00000314391_length(transcript)=862nt_BP=420nt
ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGGAACCTTCCCTGTATACTGTCAAAGCCATCCTGATTCTGGACAATGA
TGGAGATCGACTTTTTGCCAAGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGAGAAGAACATTTTCAACAAGAC
CCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCTCTATTTCTATGTGATTGGCAG
CTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCTGAGGAAAAATGTAGAAAAGCG
AGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGCACAGGCTGAGGAAAGACAACA
GCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGAGGGTGAGTCCACGCACCTACT
TCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATATTAAGAAGAAACTGAAGGAAGA
GCAAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAACGCAGACGACAGAGGTGCCGGC
TGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAACCTTATGGAAGAGGACATCAAA

>18666_18666_9_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000552362_C19orf18_chr19_58472919_ENST00000314391_length(amino acids)=227AA_BP=136
MRGKMEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYEN
ELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLLPENE

--------------------------------------------------------------
>18666_18666_10_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000553231_C19orf18_chr19_58472919_ENST00000314391_length(transcript)=793nt_BP=351nt
ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTGA
GAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATCT
CTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGCT
GAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGTCGACTGGC
ACAGGCTGAGGAAAGACAACAGCTCGAGTCACTTTATAAGAACCTCAGGATACCGTTATTAGGAGATGAAGAAGAGGGCTCAGAGGACGA
GGGTGAGTCCACGCACCTACTTCCAGAGAACGAAAATGAGCTGGAAAAGTTCATCCACTCAGTTATTATATCAAAAAGAAGCAAAAATAT
TAAGAAGAAACTGAAGGAAGAGCAAAACTCAGTAACAGAAAACAAAACAAAGAATGCGTCACATAATGGAAAAATGGAAGACTTGTGAAC
GCAGACGACAGAGGTGCCGGCTGAGGCAGAGGAGAAACTATGGGGGTGCTGGGAGACTGAGCCTGTGGGCGTGGCTTGCTCCCAGAGAAC

>18666_18666_10_COPZ1-C19orf18_COPZ1_chr12_54741628_ENST00000553231_C19orf18_chr19_58472919_ENST00000314391_length(amino acids)=204AA_BP=113
MRGKMEALILYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNV
EKRALLENMEGLFLAVDEIVDGGRLAQAEERQQLESLYKNLRIPLLGDEEEGSEDEGESTHLLPENENELEKFIHSVIISKRSKNIKKKL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for COPZ1-C19orf18

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for COPZ1-C19orf18

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for COPZ1-C19orf18

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0013146	Drug abuse	1	CTD_human
Tgene		C0013170	Drug habituation	1	CTD_human
Tgene		C0013222	Drug Use Disorders	1	CTD_human
Tgene		C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene		C0038580	Substance Dependence	1	CTD_human
Tgene		C0038586	Substance Use Disorders	1	CTD_human
Tgene		C0236969	Substance-Related Disorders	1	CTD_human
Tgene		C0740858	Substance abuse problem	1	CTD_human
Tgene		C1510472	Drug Dependence	1	CTD_human
Tgene		C4316881	Prescription Drug Abuse	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:COPZ1-C19orf18 (FusionGDB2 ID:HG22818TG147685)

Fusion Gene Summary for COPZ1-C19orf18

Fusion Gene ORF analysis for COPZ1-C19orf18

Fusion Genomic Features for COPZ1-C19orf18

Fusion Protein Features for COPZ1-C19orf18

Fusion Gene Sequence for COPZ1-C19orf18

Fusion Gene PPI Analysis for COPZ1-C19orf18

Related Drugs for COPZ1-C19orf18

Related Diseases for COPZ1-C19orf18

Fusion Gene Studies
in Kim Lab