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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NLGN4Y-SHISA6 (FusionGDB2 ID:HG22829TG388336)

Fusion Gene Summary for NLGN4Y-SHISA6

check button Fusion gene summary
Fusion gene informationFusion gene name: NLGN4Y-SHISA6
Fusion gene ID: hg22829tg388336
HgeneTgene
Gene symbol

NLGN4Y

SHISA6

Gene ID

22829

388336

Gene nameneuroligin 4 Y-linkedshisa family member 6
SynonymsHNL4Y-
Cytomap('NLGN4Y')('SHISA6')

Yq11.221

17p12

Type of geneprotein-codingprotein-coding
Descriptionneuroligin-4, Y-linkedalternative HNL4Yprotein shisa-6protein shisa-6 homologshisa homolog 6
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000476359, ENST00000297967, 
Fusion gene scores* DoF score12 X 11 X 6=7925 X 4 X 3=60
# samples 135
** MAII scorelog2(13/792*10)=-2.60698880705116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NLGN4Y [Title/Abstract] AND SHISA6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNLGN4Y(16835149)-SHISA6(11459057), # samples:1
Anticipated loss of major functional domain due to fusion event.NLGN4Y-SHISA6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NLGN4Y-SHISA6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NLGN4Y-SHISA6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NLGN4Y-SHISA6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NLGN4Y (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SHISA6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A48U-01ANLGN4YchrY

16835149

-SHISA6chr17

11459057

+


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Fusion Gene ORF analysis for NLGN4Y-SHISA6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000476359ENST00000409168NLGN4YchrY

16835149

-SHISA6chr17

11459057

+
3UTR-3CDSENST00000476359ENST00000432116NLGN4YchrY

16835149

-SHISA6chr17

11459057

+
3UTR-3CDSENST00000476359ENST00000441885NLGN4YchrY

16835149

-SHISA6chr17

11459057

+
In-frameENST00000297967ENST00000409168NLGN4YchrY

16835149

-SHISA6chr17

11459057

+
In-frameENST00000297967ENST00000432116NLGN4YchrY

16835149

-SHISA6chr17

11459057

+
In-frameENST00000297967ENST00000441885NLGN4YchrY

16835149

-SHISA6chr17

11459057

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000297967NLGN4YchrY16835149-ENST00000432116SHISA6chr1711459057+7247784991487462
ENST00000297967NLGN4YchrY16835149-ENST00000441885SHISA6chr1711459057+7247784991487462
ENST00000297967NLGN4YchrY16835149-ENST00000409168SHISA6chr1711459057+7247784991487462

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000297967ENST00000432116NLGN4YchrY16835149-SHISA6chr1711459057+0.0015927680.9984073
ENST00000297967ENST00000441885NLGN4YchrY16835149-SHISA6chr1711459057+0.0015927680.9984073
ENST00000297967ENST00000409168NLGN4YchrY16835149-SHISA6chr1711459057+0.0015927680.9984073

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Fusion Genomic Features for NLGN4Y-SHISA6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for NLGN4Y-SHISA6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrY:16835149/chr17:11459057)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSHISA6chrY:16835149chr17:11459057ENST0000040916814497_500266501.0MotifPDZ-binding
TgeneSHISA6chrY:16835149chr17:11459057ENST0000043211625497_500298533.0MotifPDZ-binding
TgeneSHISA6chrY:16835149chr17:11459057ENST0000044188536497_500317552.0MotifPDZ-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNLGN4YchrY:16835149chr17:11459057ENST00000297967-3444_676228257.0Topological domainExtracellular
HgeneNLGN4YchrY:16835149chr17:11459057ENST00000297967-34698_816228257.0Topological domainCytoplasmic
HgeneNLGN4YchrY:16835149chr17:11459057ENST00000297967-34677_697228257.0TransmembraneHelical
TgeneSHISA6chrY:16835149chr17:11459057ENST000004091681426_88266501.0Compositional biasNote=Ala-rich
TgeneSHISA6chrY:16835149chr17:11459057ENST000004321162526_88298533.0Compositional biasNote=Ala-rich
TgeneSHISA6chrY:16835149chr17:11459057ENST000004418853626_88317552.0Compositional biasNote=Ala-rich
TgeneSHISA6chrY:16835149chr17:11459057ENST0000040916814196_500266501.0Topological domainCytoplasmic
TgeneSHISA6chrY:16835149chr17:11459057ENST000004091681426_174266501.0Topological domainExtracellular
TgeneSHISA6chrY:16835149chr17:11459057ENST0000043211625196_500298533.0Topological domainCytoplasmic
TgeneSHISA6chrY:16835149chr17:11459057ENST000004321162526_174298533.0Topological domainExtracellular
TgeneSHISA6chrY:16835149chr17:11459057ENST0000044188536196_500317552.0Topological domainCytoplasmic
TgeneSHISA6chrY:16835149chr17:11459057ENST000004418853626_174317552.0Topological domainExtracellular
TgeneSHISA6chrY:16835149chr17:11459057ENST0000040916814175_195266501.0TransmembraneHelical
TgeneSHISA6chrY:16835149chr17:11459057ENST0000043211625175_195298533.0TransmembraneHelical
TgeneSHISA6chrY:16835149chr17:11459057ENST0000044188536175_195317552.0TransmembraneHelical


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Fusion Gene Sequence for NLGN4Y-SHISA6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59337_59337_1_NLGN4Y-SHISA6_NLGN4Y_chrY_16835149_ENST00000297967_SHISA6_chr17_11459057_ENST00000409168_length(transcript)=7247nt_BP=784nt
TTTTCGAAAGACTTATCTTTCTGCAGGCTCGCCTCTGAGCTTTGTCTCCTTGGAGCCACCTCACTTAGACAGCTTCGGATGTGGATGCAG
ATTTGAACCATGTTGCGTCCCCAGGGACTGCTATGGCTCCCTTTGTTGTTCACCTCTGTCTGTGTCATGTTAAACTCCAATGTTCTTCTG
TGGATAACTGCTCTTGCCATCAAGTTCACCCTCATTGACAGCCAAGCACAGTATCCAGTTGTCAACACAAATTATGGTAAAATCCAGGGC
CTAAGAACACCATTACCCAGTGAGATCTTGGGTCCAGTGGAGCAGTACTTAGGGGTCCCCTATGCCTCACCCCCAACTGGAGAGAGGCGG
TTTCAGCCACCAGAATCCCCATCCTCCTGGACTGGCATCCGAAATGCTACTCAGTTTTCTGCTGTGTGCCCCCAGCACCTGGATGAAAGA
TTCTTATTGCATGACATGCTGCCCATCTGGTTTACCACCAGTTTGGATACTTTGATGACCTATGTTCAAGATCAAAATGAAGACTGCCTT
TACTTAAACATCTATGTGCCCATGGAAGATGGAACCAACATAAAGAGAAATGCAGACGATATAACCAGTAATGACCATGGTGAAGATAAA
GATATTCATGAACAGAACAGTAAGAAGCCTGTTATGGTCTATATCCATGGGGGATCTTACATGGAGGGAACCGGTAACATGATTGATGGC
AGCATTTTGGCCAGCTATGGGAACGTCATCGTTATCACCATTAACTACCGTCTGGGAATACTAGAGAAGCCACGGATGAACAACATCCTG
ACATCAGCCACCGAGCCCTATGACCTCTCCTTCTCCCGCTCGTTCCAGAACTTGGCCCACCTGCCCCCATCCTACGAGTCTGCAGTAAAG
ACCAACCCCAGCAAGTATTCATCTCTGAAGAGGCTAACCGACAAGGAGGCTGACGAGTATTACATGAGACGGCGGCACCTGCCCGACCTG
GCTGCCCGCGGCACCCTCCCCCTCAATGTCATCCAGATGTCCCAACAGAAGCCGTTGCCAAGGGAACGACCCCGCCGGCCCATCCGGGCC
ATGTCCCAGGACAGGGTCCTGTCCCCGGATCGGGGCCTGCCAGATGAGTTCAGCATGCCCTACGACCGCATCCTGTCCGACGAGCAGCTG
CTCTCCACGGAGCGCCTGCACTCCCAGGACCCGCTGCTGTCCCCGGAGCGGACGGCCTTTCCCGAGCAGTCGCTGTCCAGGGCCATCTCG
CACACGGACGTCTTTGTGTCCACACCCGTGCTGGACCGCTACCGCATGAGCAAGATGCACTCTCATCCCAGTGCCTCCAATAACTCATAC
GCCACCCTGGGCCAGAGCCAGACGGCAGCCAAGCGTCATGCCTTTGCCTCACGCAGACACAACACGGTGGAGCAGCTGCACTACATCCCG
GGCCACCACACCTGCTACACAGCCAGCAAGACCGAAGTGACCGTGTGACCGGCGGGGCAGGGCCGGGGCTGCTGGGCGTGGCAGAGCAGA
GCGGGGGCCGGGAGGGGCCAGGAGCAGAGCTTCTAGCCTTGCCACTCTCCCTTCCCTTGTCCCCTCTGTAGGAAGTGGGGGTGGGCCACC
TTTGCCCAAAAAGCCATACCCCCGGGGACACAGCCCCGATGGCCTGGTCCAATACACTTAGACCCAGGACCAAGAGCAATCGCTCTTGCT
CCTCCAGAAGAATCAGTGGGGAGTGAGGAGGGGGCTAGGCCCCATTCTCACCCCCGACCACCTTCACCAACTCCCTTTCCGTCCCGCGCC
TCCTTCTCCCCATCCGGGGGACTCAGCTGCAGGTTCTGTCAGCAGAGAGACCCTTGCTTGACTGTGGTCTGAAGCTGCCTGGGTTTGAAG
GGGCCAGCGGGTCCAATCAGTGGGCTGACCGGATAGGCTACTCGGTCTCATTCATTCATCTAGAACCGCATCACAGAAATCTCCTAGTGC
CTAAAAACTGCCTGCTCGCTCTCTCAGAGCCAGGGAGCTGCTGTGTCCATAAGCACAATAATGATTCTTTTCTTGCCTGCTGGAACTCTC
TGGTCCCCACTGAGTGACCCTTCCTTTGCTGACCCCTGAGGGCCCAACCCTGGCCCTGTGCCCCTCCCCTCAACTCCAGGACCAGGAGGG
GTTCCCTTCCTTCAGCTGCCTCCCCATTGGTGGGAACTCCACCCCCTTCCAGCTGACTGCCCGCCCATAAGGACCCTGGGCCTGTCCTTT
CAGCGGGCTGTGCTCCTTCCCTGGCCCTGAGGATTTCACCCTTGAGTTTTCTGGGGTTTTGGCTGTAGCCTTCGCAGAGGGGAGTAGCAA
TGGGGTGCTGGCCCTCCCAGACACCCGATCATCTCCGCACTCCCTCCAGGCCTCTAGACCTGACCATGACTGCCACTCAGGCTGCCTTCT
CCACCCCTGCTCTGCTCCCAGGAGGCACCTGCGGTGGCCAGAGAGCCAGGGTGGGGAGGGCCACTGTGATGTGCGGGGTCTCGGGCTCAA
CATTCGCATCCTGCAGGGCTCCACCTGTTCCCACATGCACCTCCGGCAGGACCTAGACAGAAGTTTCTAGAGAGCAGCTTTTCAGCCCCC
AGACAAGGAGGATGAGAGGTGGTTGTCCTGCATCCTCTCCGCTCATCCTTCCTTCCCCATCTCTGTCTACCTGCTCAGTTCAGAGATCAC
TCCTACTGCCTGTGTCCCCTTCCCCCACATCCTCCCTGCAACTTTATTCCTCCTAGCTGATCCTTCAGATCCGTGCCTCCTCTGGATCAA
AGGGACAAAGACCTATTAGCAAAAGCAAACAAAGGTCCTCCAGGCGACTGGCCTAGGGGCTAACTGGGCAGGTCCCCACAGCATCATCCC
TTTGTGCAGGCACTGGGGTACCTGGTAGACCATGGTCCTCAGCTCTGTTGGGGGACCGCCACTGCCCGCCCACCTCAGCCTCTTCCCCGC
CTCCAGCCTGGGGGTTGGCATGGTGTGACGGCCTCCTGGGGAGGTGACAGTGAATTCAGCAGCATCCGCTCCCCCAAGACCAGAGAGCCT
GGTGGGGGAAAGAAGGGGTTCCCTCATTCTCAGGGCCAGGGCACCCGCTGGGTTGGGGCTGGGGGAATCAACTCCAGGCTATTGGGTGAA
GGTGTGATCCTAAAAACAGTCAGATCCAACAGCAGTGCCCTTATAAATGGGGTTTTACCTGCCCTCAGTTCTGCACTCATGGCCCTTTAA
AAAGGCGAGTGTAGAAGGAGAATTTATTGGTGTCAGCCCTGGAGATTTTTAATCTAACCAAGTCCACAAACCACAGAGAAAGCAATGGAC
TGTGTCCTTTCACTGATTTCAAGAGTTCCAAAGCTCTCATCTCCTTCTCCCCTCTGCAGGGTGTGCCTCCCAACAGGAACAGGAAACCAT
CACCCTGGATCTTAGGGGGATGGAGGCTGGGGGTTGTGAAAGCCACTGTCAGACCCCACACTGGGGATGCATTCCTGGAGTCGTGCGGCT
GGAAGGCCAGGGACTACCCTCTCTGCTTTCCTCCCAACAGACACATAAACCTTCTTAAGGGCTGGTCCCCAGGGGTTTATAAGAGTTTGT
TCCAGAAGGTGAGGCTAAGAGGGTTGGAAAGGAAGAAGTGAGTCTGAATAGAGCAGGTGGCTCCCAGCTGGGCCCCTGAGCCCAGCACCT
TTGAATCGTCTAATCTGTGGCCATCCCTTGGAAGGCAGGATGCTGGTGGTGAGGGGAAAGGACCTGAGTGGCTGAGAATGCCCTTCCCAG
GTGTCTACATGCAGGTATACACCAAACCAGAAAGCTGATCCCATCTCCAGTGTCAAAGCTTCTCAGCACCAAGTTCTCCAGCCCCCAGGG
TGACACTTTTCCCCAGGGGTCCTCCCCAAGCCCTGTCTCTGACAGGGTTTCTGTCTCTCTCAGGGGTTGTTGATGAGTTGATTCCAAGAC
ATTTCTCATCCCAGCCTTACCACTGTCTGGCTGAAAGGCTCTGATGTCAGTTGGGTTGGAAAATTCTACTGCAATGCTTACTTCTTTTCA
AGGATTTCTTCTGCTTCACCTTTGGGTCTAGAAGCAAGGAATGAAGGGAGGGAGAGAGGGAGGGAGGGAGGGGAGGAGGGAAGAAAAAAG
AAGTAGAGATAGGTCTACAGACTTGCTCCAATTCAGTCCCACATTTCAAAATCCAGAAAACTATGTCATAGCTGGGACAGAGAGGTATCC
CATTTATTCAGCTGTCCCATCCATCTTCATGGAACAAGCAAAGCCACATCAATAGGCAAGTTCACGTAGCAGATAAAAGAGGCTTCTGGG
GCTGGAACCTAGATGCCATGATTTCTAGCCCAACCAGGCTGGTGGCCTCTACCATACATAGAAGTACCATCCACCCTTACAGTAAAAGCC
TCCCTCCTGCTCACAAAGGAAGCCTAAAGCCCAAGATTTCCCTCTCCTTGTTTTATTCATTTTTGCACATCTCTGTTGCTCTAACAGAAA
TGAACTGGAATCTGCACAGGTTCTCTCCTGCCCTGAAAGTTCTGCCTGGTTTCCTTGGCCTCTGATGGCATTGAAGCTTTCACAATCCCT
CCTGCATCTCCACCTTCCCTGTCTTGCTCCAGGCTCCTGGCTCCATGCCTTCCTGTGTCAAAAAGGCTTTGCCAAGAATTACTTCACCTC
CTAACCAGGCTTCTGCCCTCAGGGCTCCCCCAGTGTCTTGGGAGTGTCTTGGGCCACACGACTGCCTCTTAGAAAGTTCCAACCTTGCCC
CCAATTCAAATTTCTCCTCCCCTCTTTCCACTCTCCCTCCCAGAAACTCCTGATTTCCAGAAAACCTCAGATTTCCAGGCCAGGTCACTC
ATTCCTTCCTCTCATCTCCCTCTTCCTCCATCTACCTTCCTCCATTCACCTTCCTCCATTCCTAATTTCTTTTCCCTGGTCTTGCTATAA
TCTCCAGCTCTAAAAATCAGAGCTCTCAATGAAAACAATGGAAGAATAAGACATTCTTTCGGTCTTCTGTTTGCCTCACTGGTGTATCCT
TCATCTCCTGCCCCTGTGAGTTGATACCCCAGTGCACGGAGCCAAGGGCTTTTCCCCTCTGAGCTCTGGGAGGGAAGGGAATGGAGCTCT
GGGTTTGAGATGTCATGGCCTGTGATAGTCAGTTTGGTTCCTGCCACTAGCAAGTCCCCTGAAGCTCCCAACCCAGCCTGATGTTAGCCC
AGAAGCTCCTGCTCTGGCCAAAGACTCCTATCCTTGAGGGCTCTCAGCCACTGCTCCAACACACTTGCCCCCTTCCTGCTTGTGTATGTC
ACTTATCCTCCTTTGTCCACAAAGACTTGAGGGCCTCCTGAGTCTCCAAGCATGGAGGAATATCCATGCCAACATCCCTGCCATCAAACT
CAATCCATTTTCTTCAGAGATACCTTGTCTGTCACCAGCCTCCAACTTCATATTCCTTCCACAGGCAACTGTGCACTTGACCCAAGGTAA
AATGAAAGGGCTGCCAATCACTCGGACTCCAGAAGGTGCCTGCCCTGAGAAGAGCTGGCATGTTACCTCCCACATACATTTCCTGTCATC
CTGTCCGAATCTGGGAAATTTTGCTCTGGAGTATTTTCAAGAAAGCGCATTGTGTTTTAATGAAGTATTTTTCAGGGTTCCAATGTTATT
TTTTATAAATGCAGCATTTTAATGGCAGATTCAATATGAAGGACATGTCTTCCTGGGCTCTATATTTGATTTTGGAAGGCAGCATACTCT
AGGAGAAAAAAAGCATAGGGCTGAGGCTCTGAAGACACAGCTTCCAGCCCTGGCTTTGTCTCCGAGGGGGAGTCATGTTCCCCACTCAGT
GCCTCAGTTTCCCCATCTGTAAAATGAGGGGCTTTGACTAGATGAGCTCTGAAGTTTCATCCAGCTCTTACACTGTAGGGCTTTCATTCC
CTGCCAGCACCTGCTCTCCCCGTTCCTCCCCACCTCCACTGAGCTGCACACATCCCACAATGCCTGCCCCACAGCGATGTCCTCAGATGT
CCTGGACAGCCACCGCACTCCTCACTAGAGCCTGGGGTGGGCCTGATGGGCTCGGCCACCCAGGGATGCCCTCGTACCTGAAGTTTAAGG
GCCTAACCATTCAATAGGTCACCAACTGTGTGCCATGGAAGCCCTCTTGTAAAGACACACCTAAACCATCCTAAGTGACTGTGGAATTCT
GGGGAATTCTGAGTTTGGAGTTTCCATTTGGATACGGTCCTTATAGCTGGAGGGAGGCGGTTCCAATTTCAGAGAGGGAGCTGGCTGGAG
AGAAAGGTCTGGAGGTTGGCCCATAAGGGCATGAAGTTTGTACTTGAGGGCAGCTGGGAAATTCATTTCAAGCTGCAGAGGAACGTGTTC
ACAGGCTGTTGTGTGGCAATGAATGTCATGATAACCCACTCTGGAATATGTGTCCTGAAGACCAAGTCTGGACACTGAGGCTCCATTCCA
ACTGGAGGAGGAGGCATCTCCATCTGGGCTGCTAGGAAGGGGCACTCATCCCATCCTAGTACCTTTGTAGCCCTTCGTCATGACACTACC
GTCCTCCCGGTGAAGGCTTGTGAAGCAAGAATGGAGAGTCCAAGTTTGTGATATTCAAACCCATCTTGTAAATCAGCAAACACATTAACC
TTCCATCAGTCAGAGAAATAATGTTGTGGCTGTGTGTTTCCTTAATGCTCTCCCTCCTGAGGGAGGAGAAGACCCTGCTCAACTTTGCTG
CCCACCCTGCAGTGACCCCTGAATGCCACACCATGGGAGGACTCATTCATTGGCTTTGTAGTGGCAAATATTCCTCTAGTTCTATAACTC
AACTAGACATTTTGTAGTAAAGAATTCTTGAAATTCTCTAATAAAAAGCAATTCTTACTGTAATATTTTTAGTTTGGGGACACAATTTCC
TAAGGGGGGATTAATGAACATTTTTATGCATTAGCCCAATTTATGAATTCCATGTTTATTATATGGTAGTACTGATGAAAAGTACCTTTC
TATCTGTATCTTTGCAGTTTCTTCGTTACTCATATGTAAGCCTCATGGTAAGCAGTGCTCTAGTAACTGCTTCTCTGTACAAATCTCATC
GTTCTACTTACCTGTCAAAGCACATTCTACATGTACTGTAAACAGATACACTTTAGTAAGATTTAGTCTTAAGGATTTTTCCACTTTTGT

>59337_59337_1_NLGN4Y-SHISA6_NLGN4Y_chrY_16835149_ENST00000297967_SHISA6_chr17_11459057_ENST00000409168_length(amino acids)=462AA_BP=228
MLRPQGLLWLPLLFTSVCVMLNSNVLLWITALAIKFTLIDSQAQYPVVNTNYGKIQGLRTPLPSEILGPVEQYLGVPYASPPTGERRFQP
PESPSSWTGIRNATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSNDHGEDKDIH
EQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILEKPRMNNILTSATEPYDLSFSRSFQNLAHLPPSYESAVKTNP
SKYSSLKRLTDKEADEYYMRRRHLPDLAARGTLPLNVIQMSQQKPLPRERPRRPIRAMSQDRVLSPDRGLPDEFSMPYDRILSDEQLLST
ERLHSQDPLLSPERTAFPEQSLSRAISHTDVFVSTPVLDRYRMSKMHSHPSASNNSYATLGQSQTAAKRHAFASRRHNTVEQLHYIPGHH

--------------------------------------------------------------
>59337_59337_2_NLGN4Y-SHISA6_NLGN4Y_chrY_16835149_ENST00000297967_SHISA6_chr17_11459057_ENST00000432116_length(transcript)=7247nt_BP=784nt
TTTTCGAAAGACTTATCTTTCTGCAGGCTCGCCTCTGAGCTTTGTCTCCTTGGAGCCACCTCACTTAGACAGCTTCGGATGTGGATGCAG
ATTTGAACCATGTTGCGTCCCCAGGGACTGCTATGGCTCCCTTTGTTGTTCACCTCTGTCTGTGTCATGTTAAACTCCAATGTTCTTCTG
TGGATAACTGCTCTTGCCATCAAGTTCACCCTCATTGACAGCCAAGCACAGTATCCAGTTGTCAACACAAATTATGGTAAAATCCAGGGC
CTAAGAACACCATTACCCAGTGAGATCTTGGGTCCAGTGGAGCAGTACTTAGGGGTCCCCTATGCCTCACCCCCAACTGGAGAGAGGCGG
TTTCAGCCACCAGAATCCCCATCCTCCTGGACTGGCATCCGAAATGCTACTCAGTTTTCTGCTGTGTGCCCCCAGCACCTGGATGAAAGA
TTCTTATTGCATGACATGCTGCCCATCTGGTTTACCACCAGTTTGGATACTTTGATGACCTATGTTCAAGATCAAAATGAAGACTGCCTT
TACTTAAACATCTATGTGCCCATGGAAGATGGAACCAACATAAAGAGAAATGCAGACGATATAACCAGTAATGACCATGGTGAAGATAAA
GATATTCATGAACAGAACAGTAAGAAGCCTGTTATGGTCTATATCCATGGGGGATCTTACATGGAGGGAACCGGTAACATGATTGATGGC
AGCATTTTGGCCAGCTATGGGAACGTCATCGTTATCACCATTAACTACCGTCTGGGAATACTAGAGAAGCCACGGATGAACAACATCCTG
ACATCAGCCACCGAGCCCTATGACCTCTCCTTCTCCCGCTCGTTCCAGAACTTGGCCCACCTGCCCCCATCCTACGAGTCTGCAGTAAAG
ACCAACCCCAGCAAGTATTCATCTCTGAAGAGGCTAACCGACAAGGAGGCTGACGAGTATTACATGAGACGGCGGCACCTGCCCGACCTG
GCTGCCCGCGGCACCCTCCCCCTCAATGTCATCCAGATGTCCCAACAGAAGCCGTTGCCAAGGGAACGACCCCGCCGGCCCATCCGGGCC
ATGTCCCAGGACAGGGTCCTGTCCCCGGATCGGGGCCTGCCAGATGAGTTCAGCATGCCCTACGACCGCATCCTGTCCGACGAGCAGCTG
CTCTCCACGGAGCGCCTGCACTCCCAGGACCCGCTGCTGTCCCCGGAGCGGACGGCCTTTCCCGAGCAGTCGCTGTCCAGGGCCATCTCG
CACACGGACGTCTTTGTGTCCACACCCGTGCTGGACCGCTACCGCATGAGCAAGATGCACTCTCATCCCAGTGCCTCCAATAACTCATAC
GCCACCCTGGGCCAGAGCCAGACGGCAGCCAAGCGTCATGCCTTTGCCTCACGCAGACACAACACGGTGGAGCAGCTGCACTACATCCCG
GGCCACCACACCTGCTACACAGCCAGCAAGACCGAAGTGACCGTGTGACCGGCGGGGCAGGGCCGGGGCTGCTGGGCGTGGCAGAGCAGA
GCGGGGGCCGGGAGGGGCCAGGAGCAGAGCTTCTAGCCTTGCCACTCTCCCTTCCCTTGTCCCCTCTGTAGGAAGTGGGGGTGGGCCACC
TTTGCCCAAAAAGCCATACCCCCGGGGACACAGCCCCGATGGCCTGGTCCAATACACTTAGACCCAGGACCAAGAGCAATCGCTCTTGCT
CCTCCAGAAGAATCAGTGGGGAGTGAGGAGGGGGCTAGGCCCCATTCTCACCCCCGACCACCTTCACCAACTCCCTTTCCGTCCCGCGCC
TCCTTCTCCCCATCCGGGGGACTCAGCTGCAGGTTCTGTCAGCAGAGAGACCCTTGCTTGACTGTGGTCTGAAGCTGCCTGGGTTTGAAG
GGGCCAGCGGGTCCAATCAGTGGGCTGACCGGATAGGCTACTCGGTCTCATTCATTCATCTAGAACCGCATCACAGAAATCTCCTAGTGC
CTAAAAACTGCCTGCTCGCTCTCTCAGAGCCAGGGAGCTGCTGTGTCCATAAGCACAATAATGATTCTTTTCTTGCCTGCTGGAACTCTC
TGGTCCCCACTGAGTGACCCTTCCTTTGCTGACCCCTGAGGGCCCAACCCTGGCCCTGTGCCCCTCCCCTCAACTCCAGGACCAGGAGGG
GTTCCCTTCCTTCAGCTGCCTCCCCATTGGTGGGAACTCCACCCCCTTCCAGCTGACTGCCCGCCCATAAGGACCCTGGGCCTGTCCTTT
CAGCGGGCTGTGCTCCTTCCCTGGCCCTGAGGATTTCACCCTTGAGTTTTCTGGGGTTTTGGCTGTAGCCTTCGCAGAGGGGAGTAGCAA
TGGGGTGCTGGCCCTCCCAGACACCCGATCATCTCCGCACTCCCTCCAGGCCTCTAGACCTGACCATGACTGCCACTCAGGCTGCCTTCT
CCACCCCTGCTCTGCTCCCAGGAGGCACCTGCGGTGGCCAGAGAGCCAGGGTGGGGAGGGCCACTGTGATGTGCGGGGTCTCGGGCTCAA
CATTCGCATCCTGCAGGGCTCCACCTGTTCCCACATGCACCTCCGGCAGGACCTAGACAGAAGTTTCTAGAGAGCAGCTTTTCAGCCCCC
AGACAAGGAGGATGAGAGGTGGTTGTCCTGCATCCTCTCCGCTCATCCTTCCTTCCCCATCTCTGTCTACCTGCTCAGTTCAGAGATCAC
TCCTACTGCCTGTGTCCCCTTCCCCCACATCCTCCCTGCAACTTTATTCCTCCTAGCTGATCCTTCAGATCCGTGCCTCCTCTGGATCAA
AGGGACAAAGACCTATTAGCAAAAGCAAACAAAGGTCCTCCAGGCGACTGGCCTAGGGGCTAACTGGGCAGGTCCCCACAGCATCATCCC
TTTGTGCAGGCACTGGGGTACCTGGTAGACCATGGTCCTCAGCTCTGTTGGGGGACCGCCACTGCCCGCCCACCTCAGCCTCTTCCCCGC
CTCCAGCCTGGGGGTTGGCATGGTGTGACGGCCTCCTGGGGAGGTGACAGTGAATTCAGCAGCATCCGCTCCCCCAAGACCAGAGAGCCT
GGTGGGGGAAAGAAGGGGTTCCCTCATTCTCAGGGCCAGGGCACCCGCTGGGTTGGGGCTGGGGGAATCAACTCCAGGCTATTGGGTGAA
GGTGTGATCCTAAAAACAGTCAGATCCAACAGCAGTGCCCTTATAAATGGGGTTTTACCTGCCCTCAGTTCTGCACTCATGGCCCTTTAA
AAAGGCGAGTGTAGAAGGAGAATTTATTGGTGTCAGCCCTGGAGATTTTTAATCTAACCAAGTCCACAAACCACAGAGAAAGCAATGGAC
TGTGTCCTTTCACTGATTTCAAGAGTTCCAAAGCTCTCATCTCCTTCTCCCCTCTGCAGGGTGTGCCTCCCAACAGGAACAGGAAACCAT
CACCCTGGATCTTAGGGGGATGGAGGCTGGGGGTTGTGAAAGCCACTGTCAGACCCCACACTGGGGATGCATTCCTGGAGTCGTGCGGCT
GGAAGGCCAGGGACTACCCTCTCTGCTTTCCTCCCAACAGACACATAAACCTTCTTAAGGGCTGGTCCCCAGGGGTTTATAAGAGTTTGT
TCCAGAAGGTGAGGCTAAGAGGGTTGGAAAGGAAGAAGTGAGTCTGAATAGAGCAGGTGGCTCCCAGCTGGGCCCCTGAGCCCAGCACCT
TTGAATCGTCTAATCTGTGGCCATCCCTTGGAAGGCAGGATGCTGGTGGTGAGGGGAAAGGACCTGAGTGGCTGAGAATGCCCTTCCCAG
GTGTCTACATGCAGGTATACACCAAACCAGAAAGCTGATCCCATCTCCAGTGTCAAAGCTTCTCAGCACCAAGTTCTCCAGCCCCCAGGG
TGACACTTTTCCCCAGGGGTCCTCCCCAAGCCCTGTCTCTGACAGGGTTTCTGTCTCTCTCAGGGGTTGTTGATGAGTTGATTCCAAGAC
ATTTCTCATCCCAGCCTTACCACTGTCTGGCTGAAAGGCTCTGATGTCAGTTGGGTTGGAAAATTCTACTGCAATGCTTACTTCTTTTCA
AGGATTTCTTCTGCTTCACCTTTGGGTCTAGAAGCAAGGAATGAAGGGAGGGAGAGAGGGAGGGAGGGAGGGGAGGAGGGAAGAAAAAAG
AAGTAGAGATAGGTCTACAGACTTGCTCCAATTCAGTCCCACATTTCAAAATCCAGAAAACTATGTCATAGCTGGGACAGAGAGGTATCC
CATTTATTCAGCTGTCCCATCCATCTTCATGGAACAAGCAAAGCCACATCAATAGGCAAGTTCACGTAGCAGATAAAAGAGGCTTCTGGG
GCTGGAACCTAGATGCCATGATTTCTAGCCCAACCAGGCTGGTGGCCTCTACCATACATAGAAGTACCATCCACCCTTACAGTAAAAGCC
TCCCTCCTGCTCACAAAGGAAGCCTAAAGCCCAAGATTTCCCTCTCCTTGTTTTATTCATTTTTGCACATCTCTGTTGCTCTAACAGAAA
TGAACTGGAATCTGCACAGGTTCTCTCCTGCCCTGAAAGTTCTGCCTGGTTTCCTTGGCCTCTGATGGCATTGAAGCTTTCACAATCCCT
CCTGCATCTCCACCTTCCCTGTCTTGCTCCAGGCTCCTGGCTCCATGCCTTCCTGTGTCAAAAAGGCTTTGCCAAGAATTACTTCACCTC
CTAACCAGGCTTCTGCCCTCAGGGCTCCCCCAGTGTCTTGGGAGTGTCTTGGGCCACACGACTGCCTCTTAGAAAGTTCCAACCTTGCCC
CCAATTCAAATTTCTCCTCCCCTCTTTCCACTCTCCCTCCCAGAAACTCCTGATTTCCAGAAAACCTCAGATTTCCAGGCCAGGTCACTC
ATTCCTTCCTCTCATCTCCCTCTTCCTCCATCTACCTTCCTCCATTCACCTTCCTCCATTCCTAATTTCTTTTCCCTGGTCTTGCTATAA
TCTCCAGCTCTAAAAATCAGAGCTCTCAATGAAAACAATGGAAGAATAAGACATTCTTTCGGTCTTCTGTTTGCCTCACTGGTGTATCCT
TCATCTCCTGCCCCTGTGAGTTGATACCCCAGTGCACGGAGCCAAGGGCTTTTCCCCTCTGAGCTCTGGGAGGGAAGGGAATGGAGCTCT
GGGTTTGAGATGTCATGGCCTGTGATAGTCAGTTTGGTTCCTGCCACTAGCAAGTCCCCTGAAGCTCCCAACCCAGCCTGATGTTAGCCC
AGAAGCTCCTGCTCTGGCCAAAGACTCCTATCCTTGAGGGCTCTCAGCCACTGCTCCAACACACTTGCCCCCTTCCTGCTTGTGTATGTC
ACTTATCCTCCTTTGTCCACAAAGACTTGAGGGCCTCCTGAGTCTCCAAGCATGGAGGAATATCCATGCCAACATCCCTGCCATCAAACT
CAATCCATTTTCTTCAGAGATACCTTGTCTGTCACCAGCCTCCAACTTCATATTCCTTCCACAGGCAACTGTGCACTTGACCCAAGGTAA
AATGAAAGGGCTGCCAATCACTCGGACTCCAGAAGGTGCCTGCCCTGAGAAGAGCTGGCATGTTACCTCCCACATACATTTCCTGTCATC
CTGTCCGAATCTGGGAAATTTTGCTCTGGAGTATTTTCAAGAAAGCGCATTGTGTTTTAATGAAGTATTTTTCAGGGTTCCAATGTTATT
TTTTATAAATGCAGCATTTTAATGGCAGATTCAATATGAAGGACATGTCTTCCTGGGCTCTATATTTGATTTTGGAAGGCAGCATACTCT
AGGAGAAAAAAAGCATAGGGCTGAGGCTCTGAAGACACAGCTTCCAGCCCTGGCTTTGTCTCCGAGGGGGAGTCATGTTCCCCACTCAGT
GCCTCAGTTTCCCCATCTGTAAAATGAGGGGCTTTGACTAGATGAGCTCTGAAGTTTCATCCAGCTCTTACACTGTAGGGCTTTCATTCC
CTGCCAGCACCTGCTCTCCCCGTTCCTCCCCACCTCCACTGAGCTGCACACATCCCACAATGCCTGCCCCACAGCGATGTCCTCAGATGT
CCTGGACAGCCACCGCACTCCTCACTAGAGCCTGGGGTGGGCCTGATGGGCTCGGCCACCCAGGGATGCCCTCGTACCTGAAGTTTAAGG
GCCTAACCATTCAATAGGTCACCAACTGTGTGCCATGGAAGCCCTCTTGTAAAGACACACCTAAACCATCCTAAGTGACTGTGGAATTCT
GGGGAATTCTGAGTTTGGAGTTTCCATTTGGATACGGTCCTTATAGCTGGAGGGAGGCGGTTCCAATTTCAGAGAGGGAGCTGGCTGGAG
AGAAAGGTCTGGAGGTTGGCCCATAAGGGCATGAAGTTTGTACTTGAGGGCAGCTGGGAAATTCATTTCAAGCTGCAGAGGAACGTGTTC
ACAGGCTGTTGTGTGGCAATGAATGTCATGATAACCCACTCTGGAATATGTGTCCTGAAGACCAAGTCTGGACACTGAGGCTCCATTCCA
ACTGGAGGAGGAGGCATCTCCATCTGGGCTGCTAGGAAGGGGCACTCATCCCATCCTAGTACCTTTGTAGCCCTTCGTCATGACACTACC
GTCCTCCCGGTGAAGGCTTGTGAAGCAAGAATGGAGAGTCCAAGTTTGTGATATTCAAACCCATCTTGTAAATCAGCAAACACATTAACC
TTCCATCAGTCAGAGAAATAATGTTGTGGCTGTGTGTTTCCTTAATGCTCTCCCTCCTGAGGGAGGAGAAGACCCTGCTCAACTTTGCTG
CCCACCCTGCAGTGACCCCTGAATGCCACACCATGGGAGGACTCATTCATTGGCTTTGTAGTGGCAAATATTCCTCTAGTTCTATAACTC
AACTAGACATTTTGTAGTAAAGAATTCTTGAAATTCTCTAATAAAAAGCAATTCTTACTGTAATATTTTTAGTTTGGGGACACAATTTCC
TAAGGGGGGATTAATGAACATTTTTATGCATTAGCCCAATTTATGAATTCCATGTTTATTATATGGTAGTACTGATGAAAAGTACCTTTC
TATCTGTATCTTTGCAGTTTCTTCGTTACTCATATGTAAGCCTCATGGTAAGCAGTGCTCTAGTAACTGCTTCTCTGTACAAATCTCATC
GTTCTACTTACCTGTCAAAGCACATTCTACATGTACTGTAAACAGATACACTTTAGTAAGATTTAGTCTTAAGGATTTTTCCACTTTTGT

>59337_59337_2_NLGN4Y-SHISA6_NLGN4Y_chrY_16835149_ENST00000297967_SHISA6_chr17_11459057_ENST00000432116_length(amino acids)=462AA_BP=228
MLRPQGLLWLPLLFTSVCVMLNSNVLLWITALAIKFTLIDSQAQYPVVNTNYGKIQGLRTPLPSEILGPVEQYLGVPYASPPTGERRFQP
PESPSSWTGIRNATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSNDHGEDKDIH
EQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILEKPRMNNILTSATEPYDLSFSRSFQNLAHLPPSYESAVKTNP
SKYSSLKRLTDKEADEYYMRRRHLPDLAARGTLPLNVIQMSQQKPLPRERPRRPIRAMSQDRVLSPDRGLPDEFSMPYDRILSDEQLLST
ERLHSQDPLLSPERTAFPEQSLSRAISHTDVFVSTPVLDRYRMSKMHSHPSASNNSYATLGQSQTAAKRHAFASRRHNTVEQLHYIPGHH

--------------------------------------------------------------
>59337_59337_3_NLGN4Y-SHISA6_NLGN4Y_chrY_16835149_ENST00000297967_SHISA6_chr17_11459057_ENST00000441885_length(transcript)=7247nt_BP=784nt
TTTTCGAAAGACTTATCTTTCTGCAGGCTCGCCTCTGAGCTTTGTCTCCTTGGAGCCACCTCACTTAGACAGCTTCGGATGTGGATGCAG
ATTTGAACCATGTTGCGTCCCCAGGGACTGCTATGGCTCCCTTTGTTGTTCACCTCTGTCTGTGTCATGTTAAACTCCAATGTTCTTCTG
TGGATAACTGCTCTTGCCATCAAGTTCACCCTCATTGACAGCCAAGCACAGTATCCAGTTGTCAACACAAATTATGGTAAAATCCAGGGC
CTAAGAACACCATTACCCAGTGAGATCTTGGGTCCAGTGGAGCAGTACTTAGGGGTCCCCTATGCCTCACCCCCAACTGGAGAGAGGCGG
TTTCAGCCACCAGAATCCCCATCCTCCTGGACTGGCATCCGAAATGCTACTCAGTTTTCTGCTGTGTGCCCCCAGCACCTGGATGAAAGA
TTCTTATTGCATGACATGCTGCCCATCTGGTTTACCACCAGTTTGGATACTTTGATGACCTATGTTCAAGATCAAAATGAAGACTGCCTT
TACTTAAACATCTATGTGCCCATGGAAGATGGAACCAACATAAAGAGAAATGCAGACGATATAACCAGTAATGACCATGGTGAAGATAAA
GATATTCATGAACAGAACAGTAAGAAGCCTGTTATGGTCTATATCCATGGGGGATCTTACATGGAGGGAACCGGTAACATGATTGATGGC
AGCATTTTGGCCAGCTATGGGAACGTCATCGTTATCACCATTAACTACCGTCTGGGAATACTAGAGAAGCCACGGATGAACAACATCCTG
ACATCAGCCACCGAGCCCTATGACCTCTCCTTCTCCCGCTCGTTCCAGAACTTGGCCCACCTGCCCCCATCCTACGAGTCTGCAGTAAAG
ACCAACCCCAGCAAGTATTCATCTCTGAAGAGGCTAACCGACAAGGAGGCTGACGAGTATTACATGAGACGGCGGCACCTGCCCGACCTG
GCTGCCCGCGGCACCCTCCCCCTCAATGTCATCCAGATGTCCCAACAGAAGCCGTTGCCAAGGGAACGACCCCGCCGGCCCATCCGGGCC
ATGTCCCAGGACAGGGTCCTGTCCCCGGATCGGGGCCTGCCAGATGAGTTCAGCATGCCCTACGACCGCATCCTGTCCGACGAGCAGCTG
CTCTCCACGGAGCGCCTGCACTCCCAGGACCCGCTGCTGTCCCCGGAGCGGACGGCCTTTCCCGAGCAGTCGCTGTCCAGGGCCATCTCG
CACACGGACGTCTTTGTGTCCACACCCGTGCTGGACCGCTACCGCATGAGCAAGATGCACTCTCATCCCAGTGCCTCCAATAACTCATAC
GCCACCCTGGGCCAGAGCCAGACGGCAGCCAAGCGTCATGCCTTTGCCTCACGCAGACACAACACGGTGGAGCAGCTGCACTACATCCCG
GGCCACCACACCTGCTACACAGCCAGCAAGACCGAAGTGACCGTGTGACCGGCGGGGCAGGGCCGGGGCTGCTGGGCGTGGCAGAGCAGA
GCGGGGGCCGGGAGGGGCCAGGAGCAGAGCTTCTAGCCTTGCCACTCTCCCTTCCCTTGTCCCCTCTGTAGGAAGTGGGGGTGGGCCACC
TTTGCCCAAAAAGCCATACCCCCGGGGACACAGCCCCGATGGCCTGGTCCAATACACTTAGACCCAGGACCAAGAGCAATCGCTCTTGCT
CCTCCAGAAGAATCAGTGGGGAGTGAGGAGGGGGCTAGGCCCCATTCTCACCCCCGACCACCTTCACCAACTCCCTTTCCGTCCCGCGCC
TCCTTCTCCCCATCCGGGGGACTCAGCTGCAGGTTCTGTCAGCAGAGAGACCCTTGCTTGACTGTGGTCTGAAGCTGCCTGGGTTTGAAG
GGGCCAGCGGGTCCAATCAGTGGGCTGACCGGATAGGCTACTCGGTCTCATTCATTCATCTAGAACCGCATCACAGAAATCTCCTAGTGC
CTAAAAACTGCCTGCTCGCTCTCTCAGAGCCAGGGAGCTGCTGTGTCCATAAGCACAATAATGATTCTTTTCTTGCCTGCTGGAACTCTC
TGGTCCCCACTGAGTGACCCTTCCTTTGCTGACCCCTGAGGGCCCAACCCTGGCCCTGTGCCCCTCCCCTCAACTCCAGGACCAGGAGGG
GTTCCCTTCCTTCAGCTGCCTCCCCATTGGTGGGAACTCCACCCCCTTCCAGCTGACTGCCCGCCCATAAGGACCCTGGGCCTGTCCTTT
CAGCGGGCTGTGCTCCTTCCCTGGCCCTGAGGATTTCACCCTTGAGTTTTCTGGGGTTTTGGCTGTAGCCTTCGCAGAGGGGAGTAGCAA
TGGGGTGCTGGCCCTCCCAGACACCCGATCATCTCCGCACTCCCTCCAGGCCTCTAGACCTGACCATGACTGCCACTCAGGCTGCCTTCT
CCACCCCTGCTCTGCTCCCAGGAGGCACCTGCGGTGGCCAGAGAGCCAGGGTGGGGAGGGCCACTGTGATGTGCGGGGTCTCGGGCTCAA
CATTCGCATCCTGCAGGGCTCCACCTGTTCCCACATGCACCTCCGGCAGGACCTAGACAGAAGTTTCTAGAGAGCAGCTTTTCAGCCCCC
AGACAAGGAGGATGAGAGGTGGTTGTCCTGCATCCTCTCCGCTCATCCTTCCTTCCCCATCTCTGTCTACCTGCTCAGTTCAGAGATCAC
TCCTACTGCCTGTGTCCCCTTCCCCCACATCCTCCCTGCAACTTTATTCCTCCTAGCTGATCCTTCAGATCCGTGCCTCCTCTGGATCAA
AGGGACAAAGACCTATTAGCAAAAGCAAACAAAGGTCCTCCAGGCGACTGGCCTAGGGGCTAACTGGGCAGGTCCCCACAGCATCATCCC
TTTGTGCAGGCACTGGGGTACCTGGTAGACCATGGTCCTCAGCTCTGTTGGGGGACCGCCACTGCCCGCCCACCTCAGCCTCTTCCCCGC
CTCCAGCCTGGGGGTTGGCATGGTGTGACGGCCTCCTGGGGAGGTGACAGTGAATTCAGCAGCATCCGCTCCCCCAAGACCAGAGAGCCT
GGTGGGGGAAAGAAGGGGTTCCCTCATTCTCAGGGCCAGGGCACCCGCTGGGTTGGGGCTGGGGGAATCAACTCCAGGCTATTGGGTGAA
GGTGTGATCCTAAAAACAGTCAGATCCAACAGCAGTGCCCTTATAAATGGGGTTTTACCTGCCCTCAGTTCTGCACTCATGGCCCTTTAA
AAAGGCGAGTGTAGAAGGAGAATTTATTGGTGTCAGCCCTGGAGATTTTTAATCTAACCAAGTCCACAAACCACAGAGAAAGCAATGGAC
TGTGTCCTTTCACTGATTTCAAGAGTTCCAAAGCTCTCATCTCCTTCTCCCCTCTGCAGGGTGTGCCTCCCAACAGGAACAGGAAACCAT
CACCCTGGATCTTAGGGGGATGGAGGCTGGGGGTTGTGAAAGCCACTGTCAGACCCCACACTGGGGATGCATTCCTGGAGTCGTGCGGCT
GGAAGGCCAGGGACTACCCTCTCTGCTTTCCTCCCAACAGACACATAAACCTTCTTAAGGGCTGGTCCCCAGGGGTTTATAAGAGTTTGT
TCCAGAAGGTGAGGCTAAGAGGGTTGGAAAGGAAGAAGTGAGTCTGAATAGAGCAGGTGGCTCCCAGCTGGGCCCCTGAGCCCAGCACCT
TTGAATCGTCTAATCTGTGGCCATCCCTTGGAAGGCAGGATGCTGGTGGTGAGGGGAAAGGACCTGAGTGGCTGAGAATGCCCTTCCCAG
GTGTCTACATGCAGGTATACACCAAACCAGAAAGCTGATCCCATCTCCAGTGTCAAAGCTTCTCAGCACCAAGTTCTCCAGCCCCCAGGG
TGACACTTTTCCCCAGGGGTCCTCCCCAAGCCCTGTCTCTGACAGGGTTTCTGTCTCTCTCAGGGGTTGTTGATGAGTTGATTCCAAGAC
ATTTCTCATCCCAGCCTTACCACTGTCTGGCTGAAAGGCTCTGATGTCAGTTGGGTTGGAAAATTCTACTGCAATGCTTACTTCTTTTCA
AGGATTTCTTCTGCTTCACCTTTGGGTCTAGAAGCAAGGAATGAAGGGAGGGAGAGAGGGAGGGAGGGAGGGGAGGAGGGAAGAAAAAAG
AAGTAGAGATAGGTCTACAGACTTGCTCCAATTCAGTCCCACATTTCAAAATCCAGAAAACTATGTCATAGCTGGGACAGAGAGGTATCC
CATTTATTCAGCTGTCCCATCCATCTTCATGGAACAAGCAAAGCCACATCAATAGGCAAGTTCACGTAGCAGATAAAAGAGGCTTCTGGG
GCTGGAACCTAGATGCCATGATTTCTAGCCCAACCAGGCTGGTGGCCTCTACCATACATAGAAGTACCATCCACCCTTACAGTAAAAGCC
TCCCTCCTGCTCACAAAGGAAGCCTAAAGCCCAAGATTTCCCTCTCCTTGTTTTATTCATTTTTGCACATCTCTGTTGCTCTAACAGAAA
TGAACTGGAATCTGCACAGGTTCTCTCCTGCCCTGAAAGTTCTGCCTGGTTTCCTTGGCCTCTGATGGCATTGAAGCTTTCACAATCCCT
CCTGCATCTCCACCTTCCCTGTCTTGCTCCAGGCTCCTGGCTCCATGCCTTCCTGTGTCAAAAAGGCTTTGCCAAGAATTACTTCACCTC
CTAACCAGGCTTCTGCCCTCAGGGCTCCCCCAGTGTCTTGGGAGTGTCTTGGGCCACACGACTGCCTCTTAGAAAGTTCCAACCTTGCCC
CCAATTCAAATTTCTCCTCCCCTCTTTCCACTCTCCCTCCCAGAAACTCCTGATTTCCAGAAAACCTCAGATTTCCAGGCCAGGTCACTC
ATTCCTTCCTCTCATCTCCCTCTTCCTCCATCTACCTTCCTCCATTCACCTTCCTCCATTCCTAATTTCTTTTCCCTGGTCTTGCTATAA
TCTCCAGCTCTAAAAATCAGAGCTCTCAATGAAAACAATGGAAGAATAAGACATTCTTTCGGTCTTCTGTTTGCCTCACTGGTGTATCCT
TCATCTCCTGCCCCTGTGAGTTGATACCCCAGTGCACGGAGCCAAGGGCTTTTCCCCTCTGAGCTCTGGGAGGGAAGGGAATGGAGCTCT
GGGTTTGAGATGTCATGGCCTGTGATAGTCAGTTTGGTTCCTGCCACTAGCAAGTCCCCTGAAGCTCCCAACCCAGCCTGATGTTAGCCC
AGAAGCTCCTGCTCTGGCCAAAGACTCCTATCCTTGAGGGCTCTCAGCCACTGCTCCAACACACTTGCCCCCTTCCTGCTTGTGTATGTC
ACTTATCCTCCTTTGTCCACAAAGACTTGAGGGCCTCCTGAGTCTCCAAGCATGGAGGAATATCCATGCCAACATCCCTGCCATCAAACT
CAATCCATTTTCTTCAGAGATACCTTGTCTGTCACCAGCCTCCAACTTCATATTCCTTCCACAGGCAACTGTGCACTTGACCCAAGGTAA
AATGAAAGGGCTGCCAATCACTCGGACTCCAGAAGGTGCCTGCCCTGAGAAGAGCTGGCATGTTACCTCCCACATACATTTCCTGTCATC
CTGTCCGAATCTGGGAAATTTTGCTCTGGAGTATTTTCAAGAAAGCGCATTGTGTTTTAATGAAGTATTTTTCAGGGTTCCAATGTTATT
TTTTATAAATGCAGCATTTTAATGGCAGATTCAATATGAAGGACATGTCTTCCTGGGCTCTATATTTGATTTTGGAAGGCAGCATACTCT
AGGAGAAAAAAAGCATAGGGCTGAGGCTCTGAAGACACAGCTTCCAGCCCTGGCTTTGTCTCCGAGGGGGAGTCATGTTCCCCACTCAGT
GCCTCAGTTTCCCCATCTGTAAAATGAGGGGCTTTGACTAGATGAGCTCTGAAGTTTCATCCAGCTCTTACACTGTAGGGCTTTCATTCC
CTGCCAGCACCTGCTCTCCCCGTTCCTCCCCACCTCCACTGAGCTGCACACATCCCACAATGCCTGCCCCACAGCGATGTCCTCAGATGT
CCTGGACAGCCACCGCACTCCTCACTAGAGCCTGGGGTGGGCCTGATGGGCTCGGCCACCCAGGGATGCCCTCGTACCTGAAGTTTAAGG
GCCTAACCATTCAATAGGTCACCAACTGTGTGCCATGGAAGCCCTCTTGTAAAGACACACCTAAACCATCCTAAGTGACTGTGGAATTCT
GGGGAATTCTGAGTTTGGAGTTTCCATTTGGATACGGTCCTTATAGCTGGAGGGAGGCGGTTCCAATTTCAGAGAGGGAGCTGGCTGGAG
AGAAAGGTCTGGAGGTTGGCCCATAAGGGCATGAAGTTTGTACTTGAGGGCAGCTGGGAAATTCATTTCAAGCTGCAGAGGAACGTGTTC
ACAGGCTGTTGTGTGGCAATGAATGTCATGATAACCCACTCTGGAATATGTGTCCTGAAGACCAAGTCTGGACACTGAGGCTCCATTCCA
ACTGGAGGAGGAGGCATCTCCATCTGGGCTGCTAGGAAGGGGCACTCATCCCATCCTAGTACCTTTGTAGCCCTTCGTCATGACACTACC
GTCCTCCCGGTGAAGGCTTGTGAAGCAAGAATGGAGAGTCCAAGTTTGTGATATTCAAACCCATCTTGTAAATCAGCAAACACATTAACC
TTCCATCAGTCAGAGAAATAATGTTGTGGCTGTGTGTTTCCTTAATGCTCTCCCTCCTGAGGGAGGAGAAGACCCTGCTCAACTTTGCTG
CCCACCCTGCAGTGACCCCTGAATGCCACACCATGGGAGGACTCATTCATTGGCTTTGTAGTGGCAAATATTCCTCTAGTTCTATAACTC
AACTAGACATTTTGTAGTAAAGAATTCTTGAAATTCTCTAATAAAAAGCAATTCTTACTGTAATATTTTTAGTTTGGGGACACAATTTCC
TAAGGGGGGATTAATGAACATTTTTATGCATTAGCCCAATTTATGAATTCCATGTTTATTATATGGTAGTACTGATGAAAAGTACCTTTC
TATCTGTATCTTTGCAGTTTCTTCGTTACTCATATGTAAGCCTCATGGTAAGCAGTGCTCTAGTAACTGCTTCTCTGTACAAATCTCATC
GTTCTACTTACCTGTCAAAGCACATTCTACATGTACTGTAAACAGATACACTTTAGTAAGATTTAGTCTTAAGGATTTTTCCACTTTTGT

>59337_59337_3_NLGN4Y-SHISA6_NLGN4Y_chrY_16835149_ENST00000297967_SHISA6_chr17_11459057_ENST00000441885_length(amino acids)=462AA_BP=228
MLRPQGLLWLPLLFTSVCVMLNSNVLLWITALAIKFTLIDSQAQYPVVNTNYGKIQGLRTPLPSEILGPVEQYLGVPYASPPTGERRFQP
PESPSSWTGIRNATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSNDHGEDKDIH
EQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILEKPRMNNILTSATEPYDLSFSRSFQNLAHLPPSYESAVKTNP
SKYSSLKRLTDKEADEYYMRRRHLPDLAARGTLPLNVIQMSQQKPLPRERPRRPIRAMSQDRVLSPDRGLPDEFSMPYDRILSDEQLLST
ERLHSQDPLLSPERTAFPEQSLSRAISHTDVFVSTPVLDRYRMSKMHSHPSASNNSYATLGQSQTAAKRHAFASRRHNTVEQLHYIPGHH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NLGN4Y-SHISA6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNLGN4YchrY:16835149chr17:11459057ENST00000297967-34359_364228.33333333333334257.0NRXN1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NLGN4Y-SHISA6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NLGN4Y-SHISA6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource