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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DLGAP4-RGMA (FusionGDB2 ID:HG22839TG56963)

Fusion Gene Summary for DLGAP4-RGMA

check button Fusion gene summary
Fusion gene informationFusion gene name: DLGAP4-RGMA
Fusion gene ID: hg22839tg56963
HgeneTgene
Gene symbol

DLGAP4

RGMA

Gene ID

22839

56963

Gene nameDLG associated protein 4repulsive guidance molecule BMP co-receptor a
SynonymsDAP-4|DAP4|DLP4|SAPAP-4|SAPAP4RGM
Cytomap('DLGAP4')('RGMA')

20q11.23

15q26.1

Type of geneprotein-codingprotein-coding
Descriptiondisks large-associated protein 4PSD-95/SAP90-binding protein 4SAP90/PSD-95-associated protein 4discs large homolog associated protein 4repulsive guidance molecule ARGM domain family, member Arepulsive guidance molecule family member a
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000475894, ENST00000340491, 
ENST00000339266, ENST00000373907, 
ENST00000373913, ENST00000401952, 
Fusion gene scores* DoF score18 X 16 X 9=25926 X 4 X 3=72
# samples 237
** MAII scorelog2(23/2592*10)=-3.49435995194025
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DLGAP4 [Title/Abstract] AND RGMA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDLGAP4(35089913)-RGMA(93595737), # samples:3
DLGAP4(35091002)-RGMA(93595737), # samples:3
Anticipated loss of major functional domain due to fusion event.DLGAP4-RGMA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DLGAP4-RGMA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRGMA

GO:0045944

positive regulation of transcription by RNA polymerase II

22728873


check buttonFusion gene breakpoints across DLGAP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RGMA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-A5-A7WK-01ADLGAP4chr20

35089913

+RGMAchr15

93595737

-
ChimerDB4UCECTCGA-A5-A7WK-01ADLGAP4chr20

35091002

-RGMAchr15

93595737

-
ChimerDB4UCECTCGA-A5-A7WKDLGAP4chr20

35089913

+RGMAchr15

93595737

-
ChimerDB4UCECTCGA-A5-A7WKDLGAP4chr20

35091002

+RGMAchr15

93595737

-
ChimerDB4UCECTCGA-A5-A7WKDLGAP4chr20

35093770

+RGMAchr15

93595737

-


Top

Fusion Gene ORF analysis for DLGAP4-RGMA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000475894ENST00000329082DLGAP4chr20

35089913

+RGMAchr15

93595737

-
3UTR-3CDSENST00000475894ENST00000425933DLGAP4chr20

35089913

+RGMAchr15

93595737

-
3UTR-3CDSENST00000475894ENST00000542321DLGAP4chr20

35089913

+RGMAchr15

93595737

-
3UTR-3CDSENST00000475894ENST00000543599DLGAP4chr20

35089913

+RGMAchr15

93595737

-
3UTR-5UTRENST00000475894ENST00000538818DLGAP4chr20

35089913

+RGMAchr15

93595737

-
3UTR-5UTRENST00000475894ENST00000555584DLGAP4chr20

35089913

+RGMAchr15

93595737

-
3UTR-5UTRENST00000475894ENST00000556087DLGAP4chr20

35089913

+RGMAchr15

93595737

-
3UTR-5UTRENST00000475894ENST00000556658DLGAP4chr20

35089913

+RGMAchr15

93595737

-
3UTR-5UTRENST00000475894ENST00000557301DLGAP4chr20

35089913

+RGMAchr15

93595737

-
3UTR-intronENST00000475894ENST00000557420DLGAP4chr20

35089913

+RGMAchr15

93595737

-
5CDS-5UTRENST00000340491ENST00000538818DLGAP4chr20

35091002

+RGMAchr15

93595737

-
5CDS-5UTRENST00000340491ENST00000555584DLGAP4chr20

35091002

+RGMAchr15

93595737

-
5CDS-5UTRENST00000340491ENST00000556087DLGAP4chr20

35091002

+RGMAchr15

93595737

-
5CDS-5UTRENST00000340491ENST00000556658DLGAP4chr20

35091002

+RGMAchr15

93595737

-
5CDS-5UTRENST00000340491ENST00000557301DLGAP4chr20

35091002

+RGMAchr15

93595737

-
5CDS-intronENST00000340491ENST00000557420DLGAP4chr20

35091002

+RGMAchr15

93595737

-
In-frameENST00000340491ENST00000329082DLGAP4chr20

35091002

+RGMAchr15

93595737

-
In-frameENST00000340491ENST00000425933DLGAP4chr20

35091002

+RGMAchr15

93595737

-
In-frameENST00000340491ENST00000542321DLGAP4chr20

35091002

+RGMAchr15

93595737

-
In-frameENST00000340491ENST00000543599DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000339266ENST00000329082DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000339266ENST00000329082DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000339266ENST00000329082DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000339266ENST00000425933DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000339266ENST00000425933DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000339266ENST00000425933DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000339266ENST00000542321DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000339266ENST00000542321DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000339266ENST00000542321DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000339266ENST00000543599DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000339266ENST00000543599DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000339266ENST00000543599DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000340491ENST00000329082DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000340491ENST00000329082DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000340491ENST00000425933DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000340491ENST00000425933DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000340491ENST00000542321DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000340491ENST00000542321DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000340491ENST00000543599DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000340491ENST00000543599DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000373907ENST00000329082DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000373907ENST00000329082DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000373907ENST00000329082DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000373907ENST00000425933DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000373907ENST00000425933DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000373907ENST00000425933DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000373907ENST00000542321DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000373907ENST00000542321DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000373907ENST00000542321DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000373907ENST00000543599DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000373907ENST00000543599DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000373907ENST00000543599DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000373913ENST00000329082DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000373913ENST00000329082DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000373913ENST00000329082DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000373913ENST00000425933DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000373913ENST00000425933DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000373913ENST00000425933DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000373913ENST00000542321DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000373913ENST00000542321DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000373913ENST00000542321DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000373913ENST00000543599DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000373913ENST00000543599DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000373913ENST00000543599DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000401952ENST00000329082DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000401952ENST00000329082DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000401952ENST00000329082DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000401952ENST00000425933DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000401952ENST00000425933DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000401952ENST00000425933DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000401952ENST00000542321DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000401952ENST00000542321DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000401952ENST00000542321DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000401952ENST00000543599DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-3CDSENST00000401952ENST00000543599DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000401952ENST00000543599DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000475894ENST00000329082DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000475894ENST00000329082DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000475894ENST00000425933DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000475894ENST00000425933DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000475894ENST00000542321DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000475894ENST00000542321DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-3CDSENST00000475894ENST00000543599DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-3CDSENST00000475894ENST00000543599DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000538818DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000538818DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000538818DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000555584DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000555584DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000555584DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000556087DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000556087DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000556087DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000556658DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000556658DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000556658DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000557301DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000557301DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000339266ENST00000557301DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000340491ENST00000538818DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000340491ENST00000538818DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000340491ENST00000555584DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000340491ENST00000555584DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000340491ENST00000556087DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000340491ENST00000556087DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000340491ENST00000556658DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000340491ENST00000556658DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000340491ENST00000557301DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000340491ENST00000557301DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000538818DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000538818DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000538818DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000555584DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000555584DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000555584DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000556087DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000556087DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000556087DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000556658DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000556658DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000556658DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000557301DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000557301DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000373907ENST00000557301DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000538818DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000538818DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000538818DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000555584DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000555584DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000555584DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000556087DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000556087DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000556087DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000556658DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000556658DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000556658DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000557301DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000557301DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000373913ENST00000557301DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000538818DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000538818DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000538818DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000555584DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000555584DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000555584DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000556087DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000556087DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000556087DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000556658DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000556658DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000556658DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000557301DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000557301DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000401952ENST00000557301DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000475894ENST00000538818DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000475894ENST00000538818DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000475894ENST00000555584DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000475894ENST00000555584DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000475894ENST00000556087DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000475894ENST00000556087DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000475894ENST00000556658DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000475894ENST00000556658DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-5UTRENST00000475894ENST00000557301DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-5UTRENST00000475894ENST00000557301DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-intronENST00000339266ENST00000557420DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-intronENST00000339266ENST00000557420DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-intronENST00000339266ENST00000557420DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-intronENST00000340491ENST00000557420DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-intronENST00000340491ENST00000557420DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-intronENST00000373907ENST00000557420DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-intronENST00000373907ENST00000557420DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-intronENST00000373907ENST00000557420DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-intronENST00000373913ENST00000557420DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-intronENST00000373913ENST00000557420DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-intronENST00000373913ENST00000557420DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-intronENST00000401952ENST00000557420DLGAP4chr20

35089913

+RGMAchr15

93595737

-
intron-intronENST00000401952ENST00000557420DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-intronENST00000401952ENST00000557420DLGAP4chr20

35093770

+RGMAchr15

93595737

-
intron-intronENST00000475894ENST00000557420DLGAP4chr20

35091002

+RGMAchr15

93595737

-
intron-intronENST00000475894ENST00000557420DLGAP4chr20

35093770

+RGMAchr15

93595737

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340491DLGAP4chr2035091002+ENST00000425933RGMAchr1593595737-36688537502075441
ENST00000340491DLGAP4chr2035091002+ENST00000543599RGMAchr1593595737-36688537502075441
ENST00000340491DLGAP4chr2035091002+ENST00000329082RGMAchr1593595737-36678537502075441
ENST00000340491DLGAP4chr2035091002+ENST00000542321RGMAchr1593595737-36588537502075441

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340491ENST00000425933DLGAP4chr2035091002+RGMAchr1593595737-0.0154303310.9845696
ENST00000340491ENST00000543599DLGAP4chr2035091002+RGMAchr1593595737-0.0154303310.9845696
ENST00000340491ENST00000329082DLGAP4chr2035091002+RGMAchr1593595737-0.0155918850.9844081
ENST00000340491ENST00000542321DLGAP4chr2035091002+RGMAchr1593595737-0.0155908160.98440915

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Fusion Genomic Features for DLGAP4-RGMA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DLGAP4-RGMA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:35089913/chr15:93595737)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLGAP4chr20:35091002chr15:93595737ENST00000339266+111267_2740993.0Compositional biasNote=Poly-Pro
HgeneDLGAP4chr20:35091002chr15:93595737ENST00000340491+17267_27410454.0Compositional biasNote=Poly-Pro
HgeneDLGAP4chr20:35091002chr15:93595737ENST00000373907+112267_2740993.0Compositional biasNote=Poly-Pro
HgeneDLGAP4chr20:35091002chr15:93595737ENST00000373913+113267_2740990.0Compositional biasNote=Poly-Pro
HgeneDLGAP4chr20:35091002chr15:93595737ENST00000401952+112267_2740990.0Compositional biasNote=Poly-Pro


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Fusion Gene Sequence for DLGAP4-RGMA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23178_23178_1_DLGAP4-RGMA_DLGAP4_chr20_35091002_ENST00000340491_RGMA_chr15_93595737_ENST00000329082_length(transcript)=3667nt_BP=853nt
GTCCGCCCGCCCGCCCGCCCGCCCGCGCTTCCGTCCTGTCCAGCCGCCAGTCCTCCAGCCCGTGTCCCCGCTCCGCCCGCTTTGTCTCTC
CCCGGCTCGCTGTCTCTTTGTCTCTGCCCTCGCGCTCCTCCGCAGCCCCTCCCTCGCTCCCCATCTCGGGTCCCCTTCTCAGAGCGCTCT
TCAGCCCTCAGAGCCGCCCTTTCTGGGCGACCCCACTCTTCGGGACTCCCCCTCAGAGCGCCCCCAGATCTTTTGGGGTTCCCCTTGAGA
ACACCTTCCACTCTCCCCAAGGGCTCCCCGTGAGTTTCTTGCACATCCTTTGGGGGTTCTGCACCCCAAGTCGCTGGGGTCTCGCCTCCT
CTGAACCCCCATTGCCCCTGGGCTTTCCCTCTTCTGGGTGTTCCCCATATCCACTGGGAGCTCCTAGGTCCCAAGTTGGGGTCTTTCTCC
TTGGGACCCCCCAATATGTCCTCAGCTCCCTGACTTCAGGAGCTCCTCTCTGCTTTCCCCTGGTTTGTCCCCTGTCGCTGTCTCTCCTTG
TTCTCTCTCAGGTCTCCGAGCACCCCCACTTCTCGGGATCGGGGTCCCCTGCTTTGCTCTCCCTGCCCCTCTGTGCCCCCACATCTGTCT
CGGTGGTCTCGCCACTCTGTGCCTCTTGCGCTGAAGGCCCCCCTTTGAGCCTGCTTCTTTGCCTGGGGCCCTTGGCCCCCCCTTGCTTTT
TCAGCCCTAGCCCCCTGTCTCCCCTTCTCTCTGCTCCTTGTCTCCCTCTCCCTTTTTCTGTCTTTGCCGGGTCTCTGGGTCTCTGACCCC
CATCCGGCCCTCATGGCTTTGTGTCTGGAGCTCTTGAAGCAATCCACCTCCCCGTGCAAGATCCTCAAGTGCAACTCTGAGTTCTGGAGC
GCCACGTCGGGCAGCCACGCCCCAGCCTCAGACGACACCCCCGAGTTCTGTGCAGCCTTGCGCAGCTACGCCCTGTGCACGCGGCGGACG
GCCCGCACCTGCCGGGGTGACCTGGCCTACCACTCGGCCGTCCATGGCATAGAGGACCTCATGAGCCAGCACAACTGCTCCAAGGATGGC
CCCACCTCGCAGCCACGCCTGCGCACGCTCCCACCGGCCGGAGACAGCCAGGAGCGCTCGGACAGCCCCGAGATCTGCCATTACGAGAAG
AGCTTTCACAAGCACTCGGCCACCCCCAACTACACGCACTGTGGCCTCTTCGGGGACCCACACCTCAGGACTTTCACCGACCGCTTCCAG
ACCTGCAAGGTGCAGGGCGCCTGGCCGCTCATCGACAATAATTACCTGAACGTGCAGGTCACCAACACGCCTGTGCTGCCCGGCTCAGCG
GCCACTGCCACCAGCAAGCTCACCATCATCTTCAAGAACTTCCAGGAGTGTGTGGACCAGAAGGTGTACCAGGCTGAGATGGACGAGCTC
CCGGCCGCCTTCGTGGATGGCTCTAAGAACGGTGGGGACAAGCACGGGGCCAACAGCCTGAAGATCACTGAGAAGGTGTCAGGCCAGCAC
GTGGAGATCCAGGCCAAGTACATCGGCACCACCATCGTGGTGCGCCAGGTGGGCCGCTACCTGACCTTTGCCGTCCGCATGCCAGAGGAA
GTGGTCAATGCTGTGGAGGACTGGGACAGCCAGGGTCTCTACCTCTGCCTGCGGGGCTGCCCCCTCAACCAGCAGATCGACTTCCAGGCC
TTCCACACCAATGCTGAGGGCACCGGTGCCCGCAGGCTGGCAGCCGCCAGCCCTGCACCCACAGCCCCCGAGACCTTCCCATACGAGACA
GCCGTGGCCAAGTGCAAGGAGAAGCTGCCGGTGGAGGACCTGTACTACCAGGCCTGCGTCTTCGACCTCCTCACCACGGGCGACGTGAAC
TTCACACTGGCCGCCTACTACGCGTTGGAGGATGTCAAGATGCTCCACTCCAACAAAGACAAACTGCACCTGTATGATAGGACTCGGGAC
CTGCCAGGCAGGGCGGCTGCGGGGCTGCCCCTGGCCCCCCGGCCCCTCCTGGGCGCCCTCGTCCCGCTCCTGGCCCTGCTCCCTGTGTTC
TGCTAGACGCGTAGATGTGGAGGGAGGCGCGGGCTCCGTCCTCTCGGCTTCCCCATGTGTGGGCTGGGACCGCCCACGGGGTGCAGATCT
CCTGGCGTGTCCACCATGGCCCCGCAGAACGCCAGGGACCGCCTGCTGCCAAGGGCTCAGGCACGGACCCCTCCCCTTCTAGTGCACGTG
ACAAGGTTGTGGTGACTGGTGCCATGATGTTTGACAGTAGAGCTGTGTGAGAGGGAGAGCAGCTCCCCTCGCCCCGCCCCTGCAGTGTGA
ATGTGTGAAACATCCCCTCAGGCTGAAGCCCCCCACCCCCACCAGAGACACACTGGGAACCGTCAGAGTCAGCTCCTTCCCCCTCGCAAT
GCACTGAAAGGCCCGGCCGACTGCTGCTCGCCGATCCGTGGGGCCCCCTGTGCCCGCCACACGCACGCACACACTCTTACACGAGAGCAC
ACTCGATCCCCCTAGGCCAGCGGGGACACCCCAGCCACACAGGGAGGCATCCTTGGGGCTTGGCCCCAGGCAGGGCAACCCCGGGGCGCT
GCTTGGCACCTTAGCAGACTGCTGGAACCTTTTGGCCAGTAGGTCGTGCCCGCCTGGTGCCTTCTGGCCTGTGGCCTCCCTGCCCATGTT
CACCTGGCTGCTGTGGGTACCAGTGCAGGTCCCGGTTTTCAGGCACCTGCTCAGCTGCCCGTCTCTGGCCTGGGCCCCTGCCCCTTCCAC
CCTGTGCTTAGAAAGTCGAAGTGCTTGGTTCTAAATGTCTAAACAGAGAAGAGATCCTTGACTTCTGTTCCTCTCTCTCCTGCAGATGCA
AGAGCTCCTGGGCAGGGGTGCCTGGGCCCCAGGGTGTGGCAGGAGACCCAGTGGATGGGGCCAGCTGGCCTGCCCTGATCCTCTGCTTCC
TCCTCACAACCCCAAGAGCCCCCAGCCCGGTCCATCCACGTCTGGAGTCTGGGGAGAGGAGCAGGGTCTTAGGACTCTCAGCTCTGAGCA
TCCCTGGCAGGGTCTTCAACCTCTAATCTCTTCCCTTAAGCCCTGTGGCCACACAGCCAGGAGAGACTTGCCGCTGGCTCCCGCCTCATT
TCAGCCCAGGGTGCTCATCCAGGGGCCCAGAACAGTCCCACCTGTGCTGCTGTGCCCACAGCACAAAGCCAGGCTTCACTCCCAAAAGTG
CAGCCAGGCCCTGGAGGGTGATCCTGCCAGCAGCCCTACAGCTCCACACCCTACCCACCCATCGGCAGCCCCTCTGCTGTTCCCCAGGGA
CCTCTCATACACTGGCCAGGAGGCTGCAGAACGTGTGTCTCCCCCTCCCTCCAAGAGGTCCTGCTCCCTCTGCCAGAACCGTGTGTGGGC
GGGTGGGAGGGCGCTCGGGGCCCGGCCCCTCCCTCTCCCTGCTGGTTTTAGTTGGTCCCTATGTTGGAAGTAAAAAGTGAAGCACTTTAT
TTTGGTTGTGTTTGCTCACGTTCTGCTTGGAAGTGGGGACCCCTCACTGCGTCCACGTGTCTGCGACCTGTGTGGAGTGTCACCGCGTGT
ACATACTGTAAATTATTTATTAATGGCTAAATGCAAGTAAAGTTTGGTTTTTTTGTTATTTTCTTTT

>23178_23178_1_DLGAP4-RGMA_DLGAP4_chr20_35091002_ENST00000340491_RGMA_chr15_93595737_ENST00000329082_length(amino acids)=441AA_BP=35
MLLVSLSLFLSLPGLWVSDPHPALMALCLELLKQSTSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAY
HSAVHGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPL
IDNNYLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGT
TIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLP
VEDLYYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYDRTRDLPGRAAAGLPLAPRPLLGALVPLLALLPVFC

--------------------------------------------------------------
>23178_23178_2_DLGAP4-RGMA_DLGAP4_chr20_35091002_ENST00000340491_RGMA_chr15_93595737_ENST00000425933_length(transcript)=3668nt_BP=853nt
GTCCGCCCGCCCGCCCGCCCGCCCGCGCTTCCGTCCTGTCCAGCCGCCAGTCCTCCAGCCCGTGTCCCCGCTCCGCCCGCTTTGTCTCTC
CCCGGCTCGCTGTCTCTTTGTCTCTGCCCTCGCGCTCCTCCGCAGCCCCTCCCTCGCTCCCCATCTCGGGTCCCCTTCTCAGAGCGCTCT
TCAGCCCTCAGAGCCGCCCTTTCTGGGCGACCCCACTCTTCGGGACTCCCCCTCAGAGCGCCCCCAGATCTTTTGGGGTTCCCCTTGAGA
ACACCTTCCACTCTCCCCAAGGGCTCCCCGTGAGTTTCTTGCACATCCTTTGGGGGTTCTGCACCCCAAGTCGCTGGGGTCTCGCCTCCT
CTGAACCCCCATTGCCCCTGGGCTTTCCCTCTTCTGGGTGTTCCCCATATCCACTGGGAGCTCCTAGGTCCCAAGTTGGGGTCTTTCTCC
TTGGGACCCCCCAATATGTCCTCAGCTCCCTGACTTCAGGAGCTCCTCTCTGCTTTCCCCTGGTTTGTCCCCTGTCGCTGTCTCTCCTTG
TTCTCTCTCAGGTCTCCGAGCACCCCCACTTCTCGGGATCGGGGTCCCCTGCTTTGCTCTCCCTGCCCCTCTGTGCCCCCACATCTGTCT
CGGTGGTCTCGCCACTCTGTGCCTCTTGCGCTGAAGGCCCCCCTTTGAGCCTGCTTCTTTGCCTGGGGCCCTTGGCCCCCCCTTGCTTTT
TCAGCCCTAGCCCCCTGTCTCCCCTTCTCTCTGCTCCTTGTCTCCCTCTCCCTTTTTCTGTCTTTGCCGGGTCTCTGGGTCTCTGACCCC
CATCCGGCCCTCATGGCTTTGTGTCTGGAGCTCTTGAAGCAATCCACCTCCCCGTGCAAGATCCTCAAGTGCAACTCTGAGTTCTGGAGC
GCCACGTCGGGCAGCCACGCCCCAGCCTCAGACGACACCCCCGAGTTCTGTGCAGCCTTGCGCAGCTACGCCCTGTGCACGCGGCGGACG
GCCCGCACCTGCCGGGGTGACCTGGCCTACCACTCGGCCGTCCATGGCATAGAGGACCTCATGAGCCAGCACAACTGCTCCAAGGATGGC
CCCACCTCGCAGCCACGCCTGCGCACGCTCCCACCGGCCGGAGACAGCCAGGAGCGCTCGGACAGCCCCGAGATCTGCCATTACGAGAAG
AGCTTTCACAAGCACTCGGCCACCCCCAACTACACGCACTGTGGCCTCTTCGGGGACCCACACCTCAGGACTTTCACCGACCGCTTCCAG
ACCTGCAAGGTGCAGGGCGCCTGGCCGCTCATCGACAATAATTACCTGAACGTGCAGGTCACCAACACGCCTGTGCTGCCCGGCTCAGCG
GCCACTGCCACCAGCAAGCTCACCATCATCTTCAAGAACTTCCAGGAGTGTGTGGACCAGAAGGTGTACCAGGCTGAGATGGACGAGCTC
CCGGCCGCCTTCGTGGATGGCTCTAAGAACGGTGGGGACAAGCACGGGGCCAACAGCCTGAAGATCACTGAGAAGGTGTCAGGCCAGCAC
GTGGAGATCCAGGCCAAGTACATCGGCACCACCATCGTGGTGCGCCAGGTGGGCCGCTACCTGACCTTTGCCGTCCGCATGCCAGAGGAA
GTGGTCAATGCTGTGGAGGACTGGGACAGCCAGGGTCTCTACCTCTGCCTGCGGGGCTGCCCCCTCAACCAGCAGATCGACTTCCAGGCC
TTCCACACCAATGCTGAGGGCACCGGTGCCCGCAGGCTGGCAGCCGCCAGCCCTGCACCCACAGCCCCCGAGACCTTCCCATACGAGACA
GCCGTGGCCAAGTGCAAGGAGAAGCTGCCGGTGGAGGACCTGTACTACCAGGCCTGCGTCTTCGACCTCCTCACCACGGGCGACGTGAAC
TTCACACTGGCCGCCTACTACGCGTTGGAGGATGTCAAGATGCTCCACTCCAACAAAGACAAACTGCACCTGTATGATAGGACTCGGGAC
CTGCCAGGCAGGGCGGCTGCGGGGCTGCCCCTGGCCCCCCGGCCCCTCCTGGGCGCCCTCGTCCCGCTCCTGGCCCTGCTCCCTGTGTTC
TGCTAGACGCGTAGATGTGGAGGGAGGCGCGGGCTCCGTCCTCTCGGCTTCCCCATGTGTGGGCTGGGACCGCCCACGGGGTGCAGATCT
CCTGGCGTGTCCACCATGGCCCCGCAGAACGCCAGGGACCGCCTGCTGCCAAGGGCTCAGGCACGGACCCCTCCCCTTCTAGTGCACGTG
ACAAGGTTGTGGTGACTGGTGCCATGATGTTTGACAGTAGAGCTGTGTGAGAGGGAGAGCAGCTCCCCTCGCCCCGCCCCTGCAGTGTGA
ATGTGTGAAACATCCCCTCAGGCTGAAGCCCCCCACCCCCACCAGAGACACACTGGGAACCGTCAGAGTCAGCTCCTTCCCCCTCGCAAT
GCACTGAAAGGCCCGGCCGACTGCTGCTCGCCGATCCGTGGGGCCCCCTGTGCCCGCCACACGCACGCACACACTCTTACACGAGAGCAC
ACTCGATCCCCCTAGGCCAGCGGGGACACCCCAGCCACACAGGGAGGCATCCTTGGGGCTTGGCCCCAGGCAGGGCAACCCCGGGGCGCT
GCTTGGCACCTTAGCAGACTGCTGGAACCTTTTGGCCAGTAGGTCGTGCCCGCCTGGTGCCTTCTGGCCTGTGGCCTCCCTGCCCATGTT
CACCTGGCTGCTGTGGGTACCAGTGCAGGTCCCGGTTTTCAGGCACCTGCTCAGCTGCCCGTCTCTGGCCTGGGCCCCTGCCCCTTCCAC
CCTGTGCTTAGAAAGTCGAAGTGCTTGGTTCTAAATGTCTAAACAGAGAAGAGATCCTTGACTTCTGTTCCTCTCTCTCCTGCAGATGCA
AGAGCTCCTGGGCAGGGGTGCCTGGGCCCCAGGGTGTGGCAGGAGACCCAGTGGATGGGGCCAGCTGGCCTGCCCTGATCCTCTGCTTCC
TCCTCACAACCCCAAGAGCCCCCAGCCCGGTCCATCCACGTCTGGAGTCTGGGGAGAGGAGCAGGGTCTTAGGACTCTCAGCTCTGAGCA
TCCCTGGCAGGGTCTTCAACCTCTAATCTCTTCCCTTAAGCCCTGTGGCCACACAGCCAGGAGAGACTTGCCGCTGGCTCCCGCCTCATT
TCAGCCCAGGGTGCTCATCCAGGGGCCCAGAACAGTCCCACCTGTGCTGCTGTGCCCACAGCACAAAGCCAGGCTTCACTCCCAAAAGTG
CAGCCAGGCCCTGGAGGGTGATCCTGCCAGCAGCCCTACAGCTCCACACCCTACCCACCCATCGGCAGCCCCTCTGCTGTTCCCCAGGGA
CCTCTCATACACTGGCCAGGAGGCTGCAGAACGTGTGTCTCCCCCTCCCTCCAAGAGGTCCTGCTCCCTCTGCCAGAACCGTGTGTGGGC
GGGTGGGAGGGCGCTCGGGGCCCGGCCCCTCCCTCTCCCTGCTGGTTTTAGTTGGTCCCTATGTTGGAAGTAAAAAGTGAAGCACTTTAT
TTTGGTTGTGTTTGCTCACGTTCTGCTTGGAAGTGGGGACCCCTCACTGCGTCCACGTGTCTGCGACCTGTGTGGAGTGTCACCGCGTGT
ACATACTGTAAATTATTTATTAATGGCTAAATGCAAGTAAAGTTTGGTTTTTTTGTTATTTTCTTTTA

>23178_23178_2_DLGAP4-RGMA_DLGAP4_chr20_35091002_ENST00000340491_RGMA_chr15_93595737_ENST00000425933_length(amino acids)=441AA_BP=35
MLLVSLSLFLSLPGLWVSDPHPALMALCLELLKQSTSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAY
HSAVHGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPL
IDNNYLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGT
TIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLP
VEDLYYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYDRTRDLPGRAAAGLPLAPRPLLGALVPLLALLPVFC

--------------------------------------------------------------
>23178_23178_3_DLGAP4-RGMA_DLGAP4_chr20_35091002_ENST00000340491_RGMA_chr15_93595737_ENST00000542321_length(transcript)=3658nt_BP=853nt
GTCCGCCCGCCCGCCCGCCCGCCCGCGCTTCCGTCCTGTCCAGCCGCCAGTCCTCCAGCCCGTGTCCCCGCTCCGCCCGCTTTGTCTCTC
CCCGGCTCGCTGTCTCTTTGTCTCTGCCCTCGCGCTCCTCCGCAGCCCCTCCCTCGCTCCCCATCTCGGGTCCCCTTCTCAGAGCGCTCT
TCAGCCCTCAGAGCCGCCCTTTCTGGGCGACCCCACTCTTCGGGACTCCCCCTCAGAGCGCCCCCAGATCTTTTGGGGTTCCCCTTGAGA
ACACCTTCCACTCTCCCCAAGGGCTCCCCGTGAGTTTCTTGCACATCCTTTGGGGGTTCTGCACCCCAAGTCGCTGGGGTCTCGCCTCCT
CTGAACCCCCATTGCCCCTGGGCTTTCCCTCTTCTGGGTGTTCCCCATATCCACTGGGAGCTCCTAGGTCCCAAGTTGGGGTCTTTCTCC
TTGGGACCCCCCAATATGTCCTCAGCTCCCTGACTTCAGGAGCTCCTCTCTGCTTTCCCCTGGTTTGTCCCCTGTCGCTGTCTCTCCTTG
TTCTCTCTCAGGTCTCCGAGCACCCCCACTTCTCGGGATCGGGGTCCCCTGCTTTGCTCTCCCTGCCCCTCTGTGCCCCCACATCTGTCT
CGGTGGTCTCGCCACTCTGTGCCTCTTGCGCTGAAGGCCCCCCTTTGAGCCTGCTTCTTTGCCTGGGGCCCTTGGCCCCCCCTTGCTTTT
TCAGCCCTAGCCCCCTGTCTCCCCTTCTCTCTGCTCCTTGTCTCCCTCTCCCTTTTTCTGTCTTTGCCGGGTCTCTGGGTCTCTGACCCC
CATCCGGCCCTCATGGCTTTGTGTCTGGAGCTCTTGAAGCAATCCACCTCCCCGTGCAAGATCCTCAAGTGCAACTCTGAGTTCTGGAGC
GCCACGTCGGGCAGCCACGCCCCAGCCTCAGACGACACCCCCGAGTTCTGTGCAGCCTTGCGCAGCTACGCCCTGTGCACGCGGCGGACG
GCCCGCACCTGCCGGGGTGACCTGGCCTACCACTCGGCCGTCCATGGCATAGAGGACCTCATGAGCCAGCACAACTGCTCCAAGGATGGC
CCCACCTCGCAGCCACGCCTGCGCACGCTCCCACCGGCCGGAGACAGCCAGGAGCGCTCGGACAGCCCCGAGATCTGCCATTACGAGAAG
AGCTTTCACAAGCACTCGGCCACCCCCAACTACACGCACTGTGGCCTCTTCGGGGACCCACACCTCAGGACTTTCACCGACCGCTTCCAG
ACCTGCAAGGTGCAGGGCGCCTGGCCGCTCATCGACAATAATTACCTGAACGTGCAGGTCACCAACACGCCTGTGCTGCCCGGCTCAGCG
GCCACTGCCACCAGCAAGCTCACCATCATCTTCAAGAACTTCCAGGAGTGTGTGGACCAGAAGGTGTACCAGGCTGAGATGGACGAGCTC
CCGGCCGCCTTCGTGGATGGCTCTAAGAACGGTGGGGACAAGCACGGGGCCAACAGCCTGAAGATCACTGAGAAGGTGTCAGGCCAGCAC
GTGGAGATCCAGGCCAAGTACATCGGCACCACCATCGTGGTGCGCCAGGTGGGCCGCTACCTGACCTTTGCCGTCCGCATGCCAGAGGAA
GTGGTCAATGCTGTGGAGGACTGGGACAGCCAGGGTCTCTACCTCTGCCTGCGGGGCTGCCCCCTCAACCAGCAGATCGACTTCCAGGCC
TTCCACACCAATGCTGAGGGCACCGGTGCCCGCAGGCTGGCAGCCGCCAGCCCTGCACCCACAGCCCCCGAGACCTTCCCATACGAGACA
GCCGTGGCCAAGTGCAAGGAGAAGCTGCCGGTGGAGGACCTGTACTACCAGGCCTGCGTCTTCGACCTCCTCACCACGGGCGACGTGAAC
TTCACACTGGCCGCCTACTACGCGTTGGAGGATGTCAAGATGCTCCACTCCAACAAAGACAAACTGCACCTGTATGATAGGACTCGGGAC
CTGCCAGGCAGGGCGGCTGCGGGGCTGCCCCTGGCCCCCCGGCCCCTCCTGGGCGCCCTCGTCCCGCTCCTGGCCCTGCTCCCTGTGTTC
TGCTAGACGCGTAGATGTGGAGGGAGGCGCGGGCTCCGTCCTCTCGGCTTCCCCATGTGTGGGCTGGGACCGCCCACGGGGTGCAGATCT
CCTGGCGTGTCCACCATGGCCCCGCAGAACGCCAGGGACCGCCTGCTGCCAAGGGCTCAGGCACGGACCCCTCCCCTTCTAGTGCACGTG
ACAAGGTTGTGGTGACTGGTGCCATGATGTTTGACAGTAGAGCTGTGTGAGAGGGAGAGCAGCTCCCCTCGCCCCGCCCCTGCAGTGTGA
ATGTGTGAAACATCCCCTCAGGCTGAAGCCCCCCACCCCCACCAGAGACACACTGGGAACCGTCAGAGTCAGCTCCTTCCCCCTCGCAAT
GCACTGAAAGGCCCGGCCGACTGCTGCTCGCCGATCCGTGGGGCCCCCTGTGCCCGCCACACGCACGCACACACTCTTACACGAGAGCAC
ACTCGATCCCCCTAGGCCAGCGGGGACACCCCAGCCACACAGGGAGGCATCCTTGGGGCTTGGCCCCAGGCAGGGCAACCCCGGGGCGCT
GCTTGGCACCTTAGCAGACTGCTGGAACCTTTTGGCCAGTAGGTCGTGCCCGCCTGGTGCCTTCTGGCCTGTGGCCTCCCTGCCCATGTT
CACCTGGCTGCTGTGGGTACCAGTGCAGGTCCCGGTTTTCAGGCACCTGCTCAGCTGCCCGTCTCTGGCCTGGGCCCCTGCCCCTTCCAC
CCTGTGCTTAGAAAGTCGAAGTGCTTGGTTCTAAATGTCTAAACAGAGAAGAGATCCTTGACTTCTGTTCCTCTCTCTCCTGCAGATGCA
AGAGCTCCTGGGCAGGGGTGCCTGGGCCCCAGGGTGTGGCAGGAGACCCAGTGGATGGGGCCAGCTGGCCTGCCCTGATCCTCTGCTTCC
TCCTCACAACCCCAAGAGCCCCCAGCCCGGTCCATCCACGTCTGGAGTCTGGGGAGAGGAGCAGGGTCTTAGGACTCTCAGCTCTGAGCA
TCCCTGGCAGGGTCTTCAACCTCTAATCTCTTCCCTTAAGCCCTGTGGCCACACAGCCAGGAGAGACTTGCCGCTGGCTCCCGCCTCATT
TCAGCCCAGGGTGCTCATCCAGGGGCCCAGAACAGTCCCACCTGTGCTGCTGTGCCCACAGCACAAAGCCAGGCTTCACTCCCAAAAGTG
CAGCCAGGCCCTGGAGGGTGATCCTGCCAGCAGCCCTACAGCTCCACACCCTACCCACCCATCGGCAGCCCCTCTGCTGTTCCCCAGGGA
CCTCTCATACACTGGCCAGGAGGCTGCAGAACGTGTGTCTCCCCCTCCCTCCAAGAGGTCCTGCTCCCTCTGCCAGAACCGTGTGTGGGC
GGGTGGGAGGGCGCTCGGGGCCCGGCCCCTCCCTCTCCCTGCTGGTTTTAGTTGGTCCCTATGTTGGAAGTAAAAAGTGAAGCACTTTAT
TTTGGTTGTGTTTGCTCACGTTCTGCTTGGAAGTGGGGACCCCTCACTGCGTCCACGTGTCTGCGACCTGTGTGGAGTGTCACCGCGTGT
ACATACTGTAAATTATTTATTAATGGCTAAATGCAAGTAAAGTTTGGTTTTTTTGTTA

>23178_23178_3_DLGAP4-RGMA_DLGAP4_chr20_35091002_ENST00000340491_RGMA_chr15_93595737_ENST00000542321_length(amino acids)=441AA_BP=35
MLLVSLSLFLSLPGLWVSDPHPALMALCLELLKQSTSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAY
HSAVHGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPL
IDNNYLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGT
TIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLP
VEDLYYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYDRTRDLPGRAAAGLPLAPRPLLGALVPLLALLPVFC

--------------------------------------------------------------
>23178_23178_4_DLGAP4-RGMA_DLGAP4_chr20_35091002_ENST00000340491_RGMA_chr15_93595737_ENST00000543599_length(transcript)=3668nt_BP=853nt
GTCCGCCCGCCCGCCCGCCCGCCCGCGCTTCCGTCCTGTCCAGCCGCCAGTCCTCCAGCCCGTGTCCCCGCTCCGCCCGCTTTGTCTCTC
CCCGGCTCGCTGTCTCTTTGTCTCTGCCCTCGCGCTCCTCCGCAGCCCCTCCCTCGCTCCCCATCTCGGGTCCCCTTCTCAGAGCGCTCT
TCAGCCCTCAGAGCCGCCCTTTCTGGGCGACCCCACTCTTCGGGACTCCCCCTCAGAGCGCCCCCAGATCTTTTGGGGTTCCCCTTGAGA
ACACCTTCCACTCTCCCCAAGGGCTCCCCGTGAGTTTCTTGCACATCCTTTGGGGGTTCTGCACCCCAAGTCGCTGGGGTCTCGCCTCCT
CTGAACCCCCATTGCCCCTGGGCTTTCCCTCTTCTGGGTGTTCCCCATATCCACTGGGAGCTCCTAGGTCCCAAGTTGGGGTCTTTCTCC
TTGGGACCCCCCAATATGTCCTCAGCTCCCTGACTTCAGGAGCTCCTCTCTGCTTTCCCCTGGTTTGTCCCCTGTCGCTGTCTCTCCTTG
TTCTCTCTCAGGTCTCCGAGCACCCCCACTTCTCGGGATCGGGGTCCCCTGCTTTGCTCTCCCTGCCCCTCTGTGCCCCCACATCTGTCT
CGGTGGTCTCGCCACTCTGTGCCTCTTGCGCTGAAGGCCCCCCTTTGAGCCTGCTTCTTTGCCTGGGGCCCTTGGCCCCCCCTTGCTTTT
TCAGCCCTAGCCCCCTGTCTCCCCTTCTCTCTGCTCCTTGTCTCCCTCTCCCTTTTTCTGTCTTTGCCGGGTCTCTGGGTCTCTGACCCC
CATCCGGCCCTCATGGCTTTGTGTCTGGAGCTCTTGAAGCAATCCACCTCCCCGTGCAAGATCCTCAAGTGCAACTCTGAGTTCTGGAGC
GCCACGTCGGGCAGCCACGCCCCAGCCTCAGACGACACCCCCGAGTTCTGTGCAGCCTTGCGCAGCTACGCCCTGTGCACGCGGCGGACG
GCCCGCACCTGCCGGGGTGACCTGGCCTACCACTCGGCCGTCCATGGCATAGAGGACCTCATGAGCCAGCACAACTGCTCCAAGGATGGC
CCCACCTCGCAGCCACGCCTGCGCACGCTCCCACCGGCCGGAGACAGCCAGGAGCGCTCGGACAGCCCCGAGATCTGCCATTACGAGAAG
AGCTTTCACAAGCACTCGGCCACCCCCAACTACACGCACTGTGGCCTCTTCGGGGACCCACACCTCAGGACTTTCACCGACCGCTTCCAG
ACCTGCAAGGTGCAGGGCGCCTGGCCGCTCATCGACAATAATTACCTGAACGTGCAGGTCACCAACACGCCTGTGCTGCCCGGCTCAGCG
GCCACTGCCACCAGCAAGCTCACCATCATCTTCAAGAACTTCCAGGAGTGTGTGGACCAGAAGGTGTACCAGGCTGAGATGGACGAGCTC
CCGGCCGCCTTCGTGGATGGCTCTAAGAACGGTGGGGACAAGCACGGGGCCAACAGCCTGAAGATCACTGAGAAGGTGTCAGGCCAGCAC
GTGGAGATCCAGGCCAAGTACATCGGCACCACCATCGTGGTGCGCCAGGTGGGCCGCTACCTGACCTTTGCCGTCCGCATGCCAGAGGAA
GTGGTCAATGCTGTGGAGGACTGGGACAGCCAGGGTCTCTACCTCTGCCTGCGGGGCTGCCCCCTCAACCAGCAGATCGACTTCCAGGCC
TTCCACACCAATGCTGAGGGCACCGGTGCCCGCAGGCTGGCAGCCGCCAGCCCTGCACCCACAGCCCCCGAGACCTTCCCATACGAGACA
GCCGTGGCCAAGTGCAAGGAGAAGCTGCCGGTGGAGGACCTGTACTACCAGGCCTGCGTCTTCGACCTCCTCACCACGGGCGACGTGAAC
TTCACACTGGCCGCCTACTACGCGTTGGAGGATGTCAAGATGCTCCACTCCAACAAAGACAAACTGCACCTGTATGATAGGACTCGGGAC
CTGCCAGGCAGGGCGGCTGCGGGGCTGCCCCTGGCCCCCCGGCCCCTCCTGGGCGCCCTCGTCCCGCTCCTGGCCCTGCTCCCTGTGTTC
TGCTAGACGCGTAGATGTGGAGGGAGGCGCGGGCTCCGTCCTCTCGGCTTCCCCATGTGTGGGCTGGGACCGCCCACGGGGTGCAGATCT
CCTGGCGTGTCCACCATGGCCCCGCAGAACGCCAGGGACCGCCTGCTGCCAAGGGCTCAGGCACGGACCCCTCCCCTTCTAGTGCACGTG
ACAAGGTTGTGGTGACTGGTGCCATGATGTTTGACAGTAGAGCTGTGTGAGAGGGAGAGCAGCTCCCCTCGCCCCGCCCCTGCAGTGTGA
ATGTGTGAAACATCCCCTCAGGCTGAAGCCCCCCACCCCCACCAGAGACACACTGGGAACCGTCAGAGTCAGCTCCTTCCCCCTCGCAAT
GCACTGAAAGGCCCGGCCGACTGCTGCTCGCCGATCCGTGGGGCCCCCTGTGCCCGCCACACGCACGCACACACTCTTACACGAGAGCAC
ACTCGATCCCCCTAGGCCAGCGGGGACACCCCAGCCACACAGGGAGGCATCCTTGGGGCTTGGCCCCAGGCAGGGCAACCCCGGGGCGCT
GCTTGGCACCTTAGCAGACTGCTGGAACCTTTTGGCCAGTAGGTCGTGCCCGCCTGGTGCCTTCTGGCCTGTGGCCTCCCTGCCCATGTT
CACCTGGCTGCTGTGGGTACCAGTGCAGGTCCCGGTTTTCAGGCACCTGCTCAGCTGCCCGTCTCTGGCCTGGGCCCCTGCCCCTTCCAC
CCTGTGCTTAGAAAGTCGAAGTGCTTGGTTCTAAATGTCTAAACAGAGAAGAGATCCTTGACTTCTGTTCCTCTCTCTCCTGCAGATGCA
AGAGCTCCTGGGCAGGGGTGCCTGGGCCCCAGGGTGTGGCAGGAGACCCAGTGGATGGGGCCAGCTGGCCTGCCCTGATCCTCTGCTTCC
TCCTCACAACCCCAAGAGCCCCCAGCCCGGTCCATCCACGTCTGGAGTCTGGGGAGAGGAGCAGGGTCTTAGGACTCTCAGCTCTGAGCA
TCCCTGGCAGGGTCTTCAACCTCTAATCTCTTCCCTTAAGCCCTGTGGCCACACAGCCAGGAGAGACTTGCCGCTGGCTCCCGCCTCATT
TCAGCCCAGGGTGCTCATCCAGGGGCCCAGAACAGTCCCACCTGTGCTGCTGTGCCCACAGCACAAAGCCAGGCTTCACTCCCAAAAGTG
CAGCCAGGCCCTGGAGGGTGATCCTGCCAGCAGCCCTACAGCTCCACACCCTACCCACCCATCGGCAGCCCCTCTGCTGTTCCCCAGGGA
CCTCTCATACACTGGCCAGGAGGCTGCAGAACGTGTGTCTCCCCCTCCCTCCAAGAGGTCCTGCTCCCTCTGCCAGAACCGTGTGTGGGC
GGGTGGGAGGGCGCTCGGGGCCCGGCCCCTCCCTCTCCCTGCTGGTTTTAGTTGGTCCCTATGTTGGAAGTAAAAAGTGAAGCACTTTAT
TTTGGTTGTGTTTGCTCACGTTCTGCTTGGAAGTGGGGACCCCTCACTGCGTCCACGTGTCTGCGACCTGTGTGGAGTGTCACCGCGTGT
ACATACTGTAAATTATTTATTAATGGCTAAATGCAAGTAAAGTTTGGTTTTTTTGTTATTTTCTTTTA

>23178_23178_4_DLGAP4-RGMA_DLGAP4_chr20_35091002_ENST00000340491_RGMA_chr15_93595737_ENST00000543599_length(amino acids)=441AA_BP=35
MLLVSLSLFLSLPGLWVSDPHPALMALCLELLKQSTSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAY
HSAVHGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPL
IDNNYLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGT
TIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLP
VEDLYYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYDRTRDLPGRAAAGLPLAPRPLLGALVPLLALLPVFC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DLGAP4-RGMA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DLGAP4-RGMA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DLGAP4-RGMA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource