Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:AAK1-YIPF1 (FusionGDB2 ID:HG22848TG54432)

Fusion Gene Summary for AAK1-YIPF1

check button Fusion gene summary
Fusion gene informationFusion gene name: AAK1-YIPF1
Fusion gene ID: hg22848tg54432
HgeneTgene
Gene symbol

AAK1

YIPF1

Gene ID

22848

54432

Gene nameAP2 associated kinase 1Yip1 domain family member 1
Synonyms-DJ167A19.1|FinGER1
Cytomap('AAK1')('YIPF1')

2p13.3

1p32.3

Type of geneprotein-codingprotein-coding
DescriptionAP2-associated protein kinase 1adaptor-associated kinase 1protein YIPF1YIP1 family member 1
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000406297, ENST00000409068, 
ENST00000409085, ENST00000470281, 
Fusion gene scores* DoF score19 X 13 X 11=27176 X 4 X 4=96
# samples 229
** MAII scorelog2(22/2717*10)=-3.62643913669732
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/96*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AAK1 [Title/Abstract] AND YIPF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAAK1(69870009)-YIPF1(54325826), # samples:1
AAK1(69870010)-YIPF1(54325826), # samples:1
Anticipated loss of major functional domain due to fusion event.AAK1-YIPF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AAK1-YIPF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AAK1-YIPF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AAK1-YIPF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AAK1-YIPF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AAK1-YIPF1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AAK1-YIPF1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAAK1

GO:0006468

protein phosphorylation

17494869|18657069

HgeneAAK1

GO:0032880

regulation of protein localization

18657069

HgeneAAK1

GO:0045747

positive regulation of Notch signaling pathway

21464124

HgeneAAK1

GO:0050821

protein stabilization

21464124

HgeneAAK1

GO:2000369

regulation of clathrin-dependent endocytosis

18657069


check buttonFusion gene breakpoints across AAK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across YIPF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-28-5213-01AAAK1chr2

69870010

-YIPF1chr1

54325826

-
ChimerDB4GBMTCGA-28-5213AAK1chr2

69870009

-YIPF1chr1

54325826

-


Top

Fusion Gene ORF analysis for AAK1-YIPF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000406297ENST00000469457AAK1chr2

69870010

-YIPF1chr1

54325826

-
5CDS-intronENST00000406297ENST00000469457AAK1chr2

69870009

-YIPF1chr1

54325826

-
5CDS-intronENST00000409068ENST00000469457AAK1chr2

69870010

-YIPF1chr1

54325826

-
5CDS-intronENST00000409068ENST00000469457AAK1chr2

69870009

-YIPF1chr1

54325826

-
5CDS-intronENST00000409085ENST00000469457AAK1chr2

69870010

-YIPF1chr1

54325826

-
5CDS-intronENST00000409085ENST00000469457AAK1chr2

69870009

-YIPF1chr1

54325826

-
Frame-shiftENST00000406297ENST00000072644AAK1chr2

69870010

-YIPF1chr1

54325826

-
Frame-shiftENST00000406297ENST00000072644AAK1chr2

69870009

-YIPF1chr1

54325826

-
Frame-shiftENST00000406297ENST00000539954AAK1chr2

69870010

-YIPF1chr1

54325826

-
Frame-shiftENST00000406297ENST00000539954AAK1chr2

69870009

-YIPF1chr1

54325826

-
Frame-shiftENST00000409068ENST00000072644AAK1chr2

69870010

-YIPF1chr1

54325826

-
Frame-shiftENST00000409068ENST00000072644AAK1chr2

69870009

-YIPF1chr1

54325826

-
Frame-shiftENST00000409068ENST00000539954AAK1chr2

69870010

-YIPF1chr1

54325826

-
Frame-shiftENST00000409068ENST00000539954AAK1chr2

69870009

-YIPF1chr1

54325826

-
Frame-shiftENST00000409085ENST00000072644AAK1chr2

69870010

-YIPF1chr1

54325826

-
Frame-shiftENST00000409085ENST00000072644AAK1chr2

69870009

-YIPF1chr1

54325826

-
Frame-shiftENST00000409085ENST00000539954AAK1chr2

69870010

-YIPF1chr1

54325826

-
Frame-shiftENST00000409085ENST00000539954AAK1chr2

69870009

-YIPF1chr1

54325826

-
In-frameENST00000406297ENST00000371399AAK1chr2

69870010

-YIPF1chr1

54325826

-
In-frameENST00000406297ENST00000371399AAK1chr2

69870009

-YIPF1chr1

54325826

-
In-frameENST00000409068ENST00000371399AAK1chr2

69870010

-YIPF1chr1

54325826

-
In-frameENST00000409068ENST00000371399AAK1chr2

69870009

-YIPF1chr1

54325826

-
In-frameENST00000409085ENST00000371399AAK1chr2

69870010

-YIPF1chr1

54325826

-
In-frameENST00000409085ENST00000371399AAK1chr2

69870009

-YIPF1chr1

54325826

-
intron-3CDSENST00000470281ENST00000072644AAK1chr2

69870010

-YIPF1chr1

54325826

-
intron-3CDSENST00000470281ENST00000072644AAK1chr2

69870009

-YIPF1chr1

54325826

-
intron-3CDSENST00000470281ENST00000371399AAK1chr2

69870010

-YIPF1chr1

54325826

-
intron-3CDSENST00000470281ENST00000371399AAK1chr2

69870009

-YIPF1chr1

54325826

-
intron-3CDSENST00000470281ENST00000539954AAK1chr2

69870010

-YIPF1chr1

54325826

-
intron-3CDSENST00000470281ENST00000539954AAK1chr2

69870009

-YIPF1chr1

54325826

-
intron-intronENST00000470281ENST00000469457AAK1chr2

69870010

-YIPF1chr1

54325826

-
intron-intronENST00000470281ENST00000469457AAK1chr2

69870009

-YIPF1chr1

54325826

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409068AAK1chr269870009-ENST00000371399YIPF1chr154325826-11134775622187
ENST00000409085AAK1chr269870009-ENST00000371399YIPF1chr154325826-11765406252207
ENST00000406297AAK1chr269870009-ENST00000371399YIPF1chr154325826-11765406252207
ENST00000409068AAK1chr269870010-ENST00000371399YIPF1chr154325826-11134775622187
ENST00000409085AAK1chr269870010-ENST00000371399YIPF1chr154325826-11765406252207
ENST00000406297AAK1chr269870010-ENST00000371399YIPF1chr154325826-11765406252207

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409068ENST00000371399AAK1chr269870009-YIPF1chr154325826-0.24275810.7572419
ENST00000409085ENST00000371399AAK1chr269870009-YIPF1chr154325826-0.137922170.86207783
ENST00000406297ENST00000371399AAK1chr269870009-YIPF1chr154325826-0.137922170.86207783
ENST00000409068ENST00000371399AAK1chr269870010-YIPF1chr154325826-0.24275810.7572419
ENST00000409085ENST00000371399AAK1chr269870010-YIPF1chr154325826-0.137922170.86207783
ENST00000406297ENST00000371399AAK1chr269870010-YIPF1chr154325826-0.137922170.86207783

Top

Fusion Genomic Features for AAK1-YIPF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for AAK1-YIPF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:69870009/chr1:54325826)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69870009chr1:54325826ENST00000406297-21812_4254864.0Compositional biasNote=Gly-rich
HgeneAAK1chr2:69870009chr1:54325826ENST00000409085-22212_4254962.0Compositional biasNote=Gly-rich
HgeneAAK1chr2:69870010chr1:54325826ENST00000406297-21812_4254864.0Compositional biasNote=Gly-rich
HgeneAAK1chr2:69870010chr1:54325826ENST00000409085-22212_4254962.0Compositional biasNote=Gly-rich
TgeneYIPF1chr2:69870009chr1:54325826ENST00000072644811278_306277422.6666666666667Topological domainLumenal
TgeneYIPF1chr2:69870009chr1:54325826ENST0000037139969141_16294259.0Topological domainLumenal
TgeneYIPF1chr2:69870009chr1:54325826ENST0000037139969184_20094259.0Topological domainCytoplasmic
TgeneYIPF1chr2:69870009chr1:54325826ENST0000037139969222_22794259.0Topological domainLumenal
TgeneYIPF1chr2:69870009chr1:54325826ENST0000037139969249_25694259.0Topological domainCytoplasmic
TgeneYIPF1chr2:69870009chr1:54325826ENST0000037139969278_30694259.0Topological domainLumenal
TgeneYIPF1chr2:69870010chr1:54325826ENST00000072644811278_306277422.6666666666667Topological domainLumenal
TgeneYIPF1chr2:69870010chr1:54325826ENST0000037139969141_16294259.0Topological domainLumenal
TgeneYIPF1chr2:69870010chr1:54325826ENST0000037139969184_20094259.0Topological domainCytoplasmic
TgeneYIPF1chr2:69870010chr1:54325826ENST0000037139969222_22794259.0Topological domainLumenal
TgeneYIPF1chr2:69870010chr1:54325826ENST0000037139969249_25694259.0Topological domainCytoplasmic
TgeneYIPF1chr2:69870010chr1:54325826ENST0000037139969278_30694259.0Topological domainLumenal
TgeneYIPF1chr2:69870009chr1:54325826ENST0000037139969120_14094259.0TransmembraneHelical
TgeneYIPF1chr2:69870009chr1:54325826ENST0000037139969163_18394259.0TransmembraneHelical
TgeneYIPF1chr2:69870009chr1:54325826ENST0000037139969201_22194259.0TransmembraneHelical
TgeneYIPF1chr2:69870009chr1:54325826ENST0000037139969228_24894259.0TransmembraneHelical
TgeneYIPF1chr2:69870009chr1:54325826ENST0000037139969257_27794259.0TransmembraneHelical
TgeneYIPF1chr2:69870010chr1:54325826ENST0000037139969120_14094259.0TransmembraneHelical
TgeneYIPF1chr2:69870010chr1:54325826ENST0000037139969163_18394259.0TransmembraneHelical
TgeneYIPF1chr2:69870010chr1:54325826ENST0000037139969201_22194259.0TransmembraneHelical
TgeneYIPF1chr2:69870010chr1:54325826ENST0000037139969228_24894259.0TransmembraneHelical
TgeneYIPF1chr2:69870010chr1:54325826ENST0000037139969257_27794259.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69870009chr1:54325826ENST00000406297-218397_61454864.0Compositional biasNote=Gln-rich
HgeneAAK1chr2:69870009chr1:54325826ENST00000406297-218658_66354864.0Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69870009chr1:54325826ENST00000409085-222397_61454962.0Compositional biasNote=Gln-rich
HgeneAAK1chr2:69870009chr1:54325826ENST00000409085-222658_66354962.0Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69870010chr1:54325826ENST00000406297-218397_61454864.0Compositional biasNote=Gln-rich
HgeneAAK1chr2:69870010chr1:54325826ENST00000406297-218658_66354864.0Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69870010chr1:54325826ENST00000409085-222397_61454962.0Compositional biasNote=Gln-rich
HgeneAAK1chr2:69870010chr1:54325826ENST00000409085-222658_66354962.0Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69870009chr1:54325826ENST00000406297-21846_31554864.0DomainProtein kinase
HgeneAAK1chr2:69870009chr1:54325826ENST00000409085-22246_31554962.0DomainProtein kinase
HgeneAAK1chr2:69870010chr1:54325826ENST00000406297-21846_31554864.0DomainProtein kinase
HgeneAAK1chr2:69870010chr1:54325826ENST00000409085-22246_31554962.0DomainProtein kinase
HgeneAAK1chr2:69870009chr1:54325826ENST00000406297-21852_6054864.0Nucleotide bindingATP
HgeneAAK1chr2:69870009chr1:54325826ENST00000409085-22252_6054962.0Nucleotide bindingATP
HgeneAAK1chr2:69870010chr1:54325826ENST00000406297-21852_6054864.0Nucleotide bindingATP
HgeneAAK1chr2:69870010chr1:54325826ENST00000409085-22252_6054962.0Nucleotide bindingATP
HgeneAAK1chr2:69870009chr1:54325826ENST00000406297-218823_96054864.0RegionClathrin-binding domain (CBD)
HgeneAAK1chr2:69870009chr1:54325826ENST00000409085-222823_96054962.0RegionClathrin-binding domain (CBD)
HgeneAAK1chr2:69870010chr1:54325826ENST00000406297-218823_96054864.0RegionClathrin-binding domain (CBD)
HgeneAAK1chr2:69870010chr1:54325826ENST00000409085-222823_96054962.0RegionClathrin-binding domain (CBD)
TgeneYIPF1chr2:69870009chr1:54325826ENST00000072644811141_162277422.6666666666667Topological domainLumenal
TgeneYIPF1chr2:69870009chr1:54325826ENST00000072644811184_200277422.6666666666667Topological domainCytoplasmic
TgeneYIPF1chr2:69870009chr1:54325826ENST000000726448111_119277422.6666666666667Topological domainCytoplasmic
TgeneYIPF1chr2:69870009chr1:54325826ENST00000072644811222_227277422.6666666666667Topological domainLumenal
TgeneYIPF1chr2:69870009chr1:54325826ENST00000072644811249_256277422.6666666666667Topological domainCytoplasmic
TgeneYIPF1chr2:69870009chr1:54325826ENST00000371399691_11994259.0Topological domainCytoplasmic
TgeneYIPF1chr2:69870010chr1:54325826ENST00000072644811141_162277422.6666666666667Topological domainLumenal
TgeneYIPF1chr2:69870010chr1:54325826ENST00000072644811184_200277422.6666666666667Topological domainCytoplasmic
TgeneYIPF1chr2:69870010chr1:54325826ENST000000726448111_119277422.6666666666667Topological domainCytoplasmic
TgeneYIPF1chr2:69870010chr1:54325826ENST00000072644811222_227277422.6666666666667Topological domainLumenal
TgeneYIPF1chr2:69870010chr1:54325826ENST00000072644811249_256277422.6666666666667Topological domainCytoplasmic
TgeneYIPF1chr2:69870010chr1:54325826ENST00000371399691_11994259.0Topological domainCytoplasmic
TgeneYIPF1chr2:69870009chr1:54325826ENST00000072644811120_140277422.6666666666667TransmembraneHelical
TgeneYIPF1chr2:69870009chr1:54325826ENST00000072644811163_183277422.6666666666667TransmembraneHelical
TgeneYIPF1chr2:69870009chr1:54325826ENST00000072644811201_221277422.6666666666667TransmembraneHelical
TgeneYIPF1chr2:69870009chr1:54325826ENST00000072644811228_248277422.6666666666667TransmembraneHelical
TgeneYIPF1chr2:69870009chr1:54325826ENST00000072644811257_277277422.6666666666667TransmembraneHelical
TgeneYIPF1chr2:69870010chr1:54325826ENST00000072644811120_140277422.6666666666667TransmembraneHelical
TgeneYIPF1chr2:69870010chr1:54325826ENST00000072644811163_183277422.6666666666667TransmembraneHelical
TgeneYIPF1chr2:69870010chr1:54325826ENST00000072644811201_221277422.6666666666667TransmembraneHelical
TgeneYIPF1chr2:69870010chr1:54325826ENST00000072644811228_248277422.6666666666667TransmembraneHelical
TgeneYIPF1chr2:69870010chr1:54325826ENST00000072644811257_277277422.6666666666667TransmembraneHelical


Top

Fusion Gene Sequence for AAK1-YIPF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72_72_1_AAK1-YIPF1_AAK1_chr2_69870009_ENST00000406297_YIPF1_chr1_54325826_ENST00000371399_length(transcript)=1176nt_BP=540nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GCATACTTTTTTGATGCACCAGAGATGGACCATCTCCCAACAACTACAGCTACTCCAAACCAAACAGTTGCTGCAGCCAAGTCCAGCTAA
TGAGGAAATTCTCTTTTGTTTTTTGGAGCATGGTTCTTTGGGAAGTGGCATCCACTGCAGGAAAGCAGAATGAGCAGAGCCAGCAGAACT
GATGGAGTGGCACAAATTCCCAGTGTCTGGATGGTGCCACACTGGCGCCTAATCACCCGTTTAACAAGCAGAAATTAAATGTTGCTCAGC
ACATGTGTCTTTCAGCTCTTCCTTTTCACCCATGGATGATCATTGCGAGCATGCGCTGATTGGACTGAAATGCCAGGGAATAGGTTAGGC
ATGCTCAGTGCCGTCCCTTTGCCACCACAGTCAAATGACATGCTTCACTGTGGTACCTTAATACCTGAAATAGAACCATGGAAAATTCTG
ATGTCCTCTCTCTGAATTATGTACAGACTACCTGGGGGATCCTCTTCTCTCCAAATGTTAGCCATCCTGAAGTAGCCGAACAGTAGAAAC
TTTGGTGGGGATTAACCGGGAGCTTGAAAATTTGTCTTTGGTAACCTGATACTGGACAGCTGAACTGAATGGCTGCAAAATAAATACCTC

>72_72_1_AAK1-YIPF1_AAK1_chr2_69870009_ENST00000406297_YIPF1_chr1_54325826_ENST00000371399_length(amino acids)=207AA_BP=1
MDLAAATVWFGVAVVVGRWSISGASKKYAFRQHLVHCDLLSPDAEDSSDVATAQARGAAPSSAGAGAQARAALLSPGVEKLLHLANREQQ
SKIPMVSRFFFFFFFFKKRDPRISSQISPRRGATRIRPWGWGLREDAYRNMRVNRAAGPLLLQKAIRVSLNLRRLGGRRPATSPATLSRP

--------------------------------------------------------------
>72_72_2_AAK1-YIPF1_AAK1_chr2_69870009_ENST00000409068_YIPF1_chr1_54325826_ENST00000371399_length(transcript)=1113nt_BP=477nt
CTCTGCGTCGCAGGCCGGCCCGGCGGCCGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTT
ACACGAATCGCTTTCTGGAGGAGGAGGGGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCAC
GGCCGGATTCGGGTGGCTCCTCTCCGAGGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAAT
CTAGAAACCATCGGTATTTTGCTTTGCTGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCC
TGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGG
TCACAGTGGACGAGGTGTTGGCGGAAGGCATACTTTTTTGATGCACCAGAGATGGACCATCTCCCAACAACTACAGCTACTCCAAACCAA
ACAGTTGCTGCAGCCAAGTCCAGCTAATGAGGAAATTCTCTTTTGTTTTTTGGAGCATGGTTCTTTGGGAAGTGGCATCCACTGCAGGAA
AGCAGAATGAGCAGAGCCAGCAGAACTGATGGAGTGGCACAAATTCCCAGTGTCTGGATGGTGCCACACTGGCGCCTAATCACCCGTTTA
ACAAGCAGAAATTAAATGTTGCTCAGCACATGTGTCTTTCAGCTCTTCCTTTTCACCCATGGATGATCATTGCGAGCATGCGCTGATTGG
ACTGAAATGCCAGGGAATAGGTTAGGCATGCTCAGTGCCGTCCCTTTGCCACCACAGTCAAATGACATGCTTCACTGTGGTACCTTAATA
CCTGAAATAGAACCATGGAAAATTCTGATGTCCTCTCTCTGAATTATGTACAGACTACCTGGGGGATCCTCTTCTCTCCAAATGTTAGCC
ATCCTGAAGTAGCCGAACAGTAGAAACTTTGGTGGGGATTAACCGGGAGCTTGAAAATTTGTCTTTGGTAACCTGATACTGGACAGCTGA

>72_72_2_AAK1-YIPF1_AAK1_chr2_69870009_ENST00000409068_YIPF1_chr1_54325826_ENST00000371399_length(amino acids)=187AA_BP=1
MDLAAATVWFGVAVVVGRWSISGASKKYAFRQHLVHCDLLSPDAEDSSDVATAQARGAAPSSAGAGAQARAALLSPGVEKLLHLANREQQ
SKIPMVSRFFFFFFFFKKRDPRISSQISPRRGATRIRPWGWGLREDAYRNMRVNRAAGPLLLQKAIRVSLNLRRLGGRRPATSPATLSRP

--------------------------------------------------------------
>72_72_3_AAK1-YIPF1_AAK1_chr2_69870009_ENST00000409085_YIPF1_chr1_54325826_ENST00000371399_length(transcript)=1176nt_BP=540nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GCATACTTTTTTGATGCACCAGAGATGGACCATCTCCCAACAACTACAGCTACTCCAAACCAAACAGTTGCTGCAGCCAAGTCCAGCTAA
TGAGGAAATTCTCTTTTGTTTTTTGGAGCATGGTTCTTTGGGAAGTGGCATCCACTGCAGGAAAGCAGAATGAGCAGAGCCAGCAGAACT
GATGGAGTGGCACAAATTCCCAGTGTCTGGATGGTGCCACACTGGCGCCTAATCACCCGTTTAACAAGCAGAAATTAAATGTTGCTCAGC
ACATGTGTCTTTCAGCTCTTCCTTTTCACCCATGGATGATCATTGCGAGCATGCGCTGATTGGACTGAAATGCCAGGGAATAGGTTAGGC
ATGCTCAGTGCCGTCCCTTTGCCACCACAGTCAAATGACATGCTTCACTGTGGTACCTTAATACCTGAAATAGAACCATGGAAAATTCTG
ATGTCCTCTCTCTGAATTATGTACAGACTACCTGGGGGATCCTCTTCTCTCCAAATGTTAGCCATCCTGAAGTAGCCGAACAGTAGAAAC
TTTGGTGGGGATTAACCGGGAGCTTGAAAATTTGTCTTTGGTAACCTGATACTGGACAGCTGAACTGAATGGCTGCAAAATAAATACCTC

>72_72_3_AAK1-YIPF1_AAK1_chr2_69870009_ENST00000409085_YIPF1_chr1_54325826_ENST00000371399_length(amino acids)=207AA_BP=1
MDLAAATVWFGVAVVVGRWSISGASKKYAFRQHLVHCDLLSPDAEDSSDVATAQARGAAPSSAGAGAQARAALLSPGVEKLLHLANREQQ
SKIPMVSRFFFFFFFFKKRDPRISSQISPRRGATRIRPWGWGLREDAYRNMRVNRAAGPLLLQKAIRVSLNLRRLGGRRPATSPATLSRP

--------------------------------------------------------------
>72_72_4_AAK1-YIPF1_AAK1_chr2_69870010_ENST00000406297_YIPF1_chr1_54325826_ENST00000371399_length(transcript)=1176nt_BP=540nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GCATACTTTTTTGATGCACCAGAGATGGACCATCTCCCAACAACTACAGCTACTCCAAACCAAACAGTTGCTGCAGCCAAGTCCAGCTAA
TGAGGAAATTCTCTTTTGTTTTTTGGAGCATGGTTCTTTGGGAAGTGGCATCCACTGCAGGAAAGCAGAATGAGCAGAGCCAGCAGAACT
GATGGAGTGGCACAAATTCCCAGTGTCTGGATGGTGCCACACTGGCGCCTAATCACCCGTTTAACAAGCAGAAATTAAATGTTGCTCAGC
ACATGTGTCTTTCAGCTCTTCCTTTTCACCCATGGATGATCATTGCGAGCATGCGCTGATTGGACTGAAATGCCAGGGAATAGGTTAGGC
ATGCTCAGTGCCGTCCCTTTGCCACCACAGTCAAATGACATGCTTCACTGTGGTACCTTAATACCTGAAATAGAACCATGGAAAATTCTG
ATGTCCTCTCTCTGAATTATGTACAGACTACCTGGGGGATCCTCTTCTCTCCAAATGTTAGCCATCCTGAAGTAGCCGAACAGTAGAAAC
TTTGGTGGGGATTAACCGGGAGCTTGAAAATTTGTCTTTGGTAACCTGATACTGGACAGCTGAACTGAATGGCTGCAAAATAAATACCTC

>72_72_4_AAK1-YIPF1_AAK1_chr2_69870010_ENST00000406297_YIPF1_chr1_54325826_ENST00000371399_length(amino acids)=207AA_BP=1
MDLAAATVWFGVAVVVGRWSISGASKKYAFRQHLVHCDLLSPDAEDSSDVATAQARGAAPSSAGAGAQARAALLSPGVEKLLHLANREQQ
SKIPMVSRFFFFFFFFKKRDPRISSQISPRRGATRIRPWGWGLREDAYRNMRVNRAAGPLLLQKAIRVSLNLRRLGGRRPATSPATLSRP

--------------------------------------------------------------
>72_72_5_AAK1-YIPF1_AAK1_chr2_69870010_ENST00000409068_YIPF1_chr1_54325826_ENST00000371399_length(transcript)=1113nt_BP=477nt
CTCTGCGTCGCAGGCCGGCCCGGCGGCCGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTT
ACACGAATCGCTTTCTGGAGGAGGAGGGGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCAC
GGCCGGATTCGGGTGGCTCCTCTCCGAGGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAAT
CTAGAAACCATCGGTATTTTGCTTTGCTGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCC
TGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGG
TCACAGTGGACGAGGTGTTGGCGGAAGGCATACTTTTTTGATGCACCAGAGATGGACCATCTCCCAACAACTACAGCTACTCCAAACCAA
ACAGTTGCTGCAGCCAAGTCCAGCTAATGAGGAAATTCTCTTTTGTTTTTTGGAGCATGGTTCTTTGGGAAGTGGCATCCACTGCAGGAA
AGCAGAATGAGCAGAGCCAGCAGAACTGATGGAGTGGCACAAATTCCCAGTGTCTGGATGGTGCCACACTGGCGCCTAATCACCCGTTTA
ACAAGCAGAAATTAAATGTTGCTCAGCACATGTGTCTTTCAGCTCTTCCTTTTCACCCATGGATGATCATTGCGAGCATGCGCTGATTGG
ACTGAAATGCCAGGGAATAGGTTAGGCATGCTCAGTGCCGTCCCTTTGCCACCACAGTCAAATGACATGCTTCACTGTGGTACCTTAATA
CCTGAAATAGAACCATGGAAAATTCTGATGTCCTCTCTCTGAATTATGTACAGACTACCTGGGGGATCCTCTTCTCTCCAAATGTTAGCC
ATCCTGAAGTAGCCGAACAGTAGAAACTTTGGTGGGGATTAACCGGGAGCTTGAAAATTTGTCTTTGGTAACCTGATACTGGACAGCTGA

>72_72_5_AAK1-YIPF1_AAK1_chr2_69870010_ENST00000409068_YIPF1_chr1_54325826_ENST00000371399_length(amino acids)=187AA_BP=1
MDLAAATVWFGVAVVVGRWSISGASKKYAFRQHLVHCDLLSPDAEDSSDVATAQARGAAPSSAGAGAQARAALLSPGVEKLLHLANREQQ
SKIPMVSRFFFFFFFFKKRDPRISSQISPRRGATRIRPWGWGLREDAYRNMRVNRAAGPLLLQKAIRVSLNLRRLGGRRPATSPATLSRP

--------------------------------------------------------------
>72_72_6_AAK1-YIPF1_AAK1_chr2_69870010_ENST00000409085_YIPF1_chr1_54325826_ENST00000371399_length(transcript)=1176nt_BP=540nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GCATACTTTTTTGATGCACCAGAGATGGACCATCTCCCAACAACTACAGCTACTCCAAACCAAACAGTTGCTGCAGCCAAGTCCAGCTAA
TGAGGAAATTCTCTTTTGTTTTTTGGAGCATGGTTCTTTGGGAAGTGGCATCCACTGCAGGAAAGCAGAATGAGCAGAGCCAGCAGAACT
GATGGAGTGGCACAAATTCCCAGTGTCTGGATGGTGCCACACTGGCGCCTAATCACCCGTTTAACAAGCAGAAATTAAATGTTGCTCAGC
ACATGTGTCTTTCAGCTCTTCCTTTTCACCCATGGATGATCATTGCGAGCATGCGCTGATTGGACTGAAATGCCAGGGAATAGGTTAGGC
ATGCTCAGTGCCGTCCCTTTGCCACCACAGTCAAATGACATGCTTCACTGTGGTACCTTAATACCTGAAATAGAACCATGGAAAATTCTG
ATGTCCTCTCTCTGAATTATGTACAGACTACCTGGGGGATCCTCTTCTCTCCAAATGTTAGCCATCCTGAAGTAGCCGAACAGTAGAAAC
TTTGGTGGGGATTAACCGGGAGCTTGAAAATTTGTCTTTGGTAACCTGATACTGGACAGCTGAACTGAATGGCTGCAAAATAAATACCTC

>72_72_6_AAK1-YIPF1_AAK1_chr2_69870010_ENST00000409085_YIPF1_chr1_54325826_ENST00000371399_length(amino acids)=207AA_BP=1
MDLAAATVWFGVAVVVGRWSISGASKKYAFRQHLVHCDLLSPDAEDSSDVATAQARGAAPSSAGAGAQARAALLSPGVEKLLHLANREQQ
SKIPMVSRFFFFFFFFKKRDPRISSQISPRRGATRIRPWGWGLREDAYRNMRVNRAAGPLLLQKAIRVSLNLRRLGGRRPATSPATLSRP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AAK1-YIPF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for AAK1-YIPF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for AAK1-YIPF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource