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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DIS3-KLF12 (FusionGDB2 ID:HG22894TG11278) |
Fusion Gene Summary for DIS3-KLF12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DIS3-KLF12 | Fusion gene ID: hg22894tg11278 | Hgene | Tgene | Gene symbol | DIS3 | KLF12 | Gene ID | 22894 | 11278 |
| Gene name | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease | Kruppel like factor 12 | |
| Synonyms | 2810028N01Rik|EXOSC11|KIAA1008|RRP44|dis3p | AP-2rep|AP2REP|HSPC122 | |
| Cytomap | ('DIS3')('KLF12') 13q21.33 | 13q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | exosome complex exonuclease RRP44DIS3 exosome endoribonuclease and 3'-5' exoribonucleaseDIS3 mitotic control homologexosome component 11mitotic control protein dis3 homologribosomal RNA-processing protein 44 | Krueppel-like factor 12AP-2 repressorAP-2rep transcription factorKLF12 zinc finger transcriptional repressortranscriptional repressor AP-2rep | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000377767, ENST00000377780, ENST00000545453, ENST00000475871, | ||
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 13 X 13 X 6=1014 |
| # samples | 3 | 16 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(16/1014*10)=-2.66391384211598 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DIS3 [Title/Abstract] AND KLF12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DIS3(73345933)-KLF12(74420510), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | DIS3-KLF12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DIS3-KLF12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DIS3-KLF12 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. DIS3-KLF12 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DIS3-KLF12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. DIS3-KLF12 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KLF12 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16615998 |
| Fusion gene breakpoints across DIS3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across KLF12 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-VQ-A922-01A | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| ChimerDB4 | STAD | TCGA-VQ-A922 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - |
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Fusion Gene ORF analysis for DIS3-KLF12 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000377767 | ENST00000472022 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| 5CDS-5UTR | ENST00000377767 | ENST00000472022 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - |
| 5CDS-5UTR | ENST00000377780 | ENST00000472022 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| 5CDS-5UTR | ENST00000377780 | ENST00000472022 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - |
| 5CDS-5UTR | ENST00000545453 | ENST00000472022 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| 5CDS-5UTR | ENST00000545453 | ENST00000472022 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - |
| Frame-shift | ENST00000545453 | ENST00000377666 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| Frame-shift | ENST00000545453 | ENST00000377666 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - |
| Frame-shift | ENST00000545453 | ENST00000377669 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| Frame-shift | ENST00000545453 | ENST00000377669 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - |
| In-frame | ENST00000377767 | ENST00000377666 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| In-frame | ENST00000377767 | ENST00000377666 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - |
| In-frame | ENST00000377767 | ENST00000377669 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| In-frame | ENST00000377767 | ENST00000377669 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - |
| In-frame | ENST00000377780 | ENST00000377666 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| In-frame | ENST00000377780 | ENST00000377666 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - |
| In-frame | ENST00000377780 | ENST00000377669 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| In-frame | ENST00000377780 | ENST00000377669 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - |
| intron-3CDS | ENST00000475871 | ENST00000377666 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| intron-3CDS | ENST00000475871 | ENST00000377666 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - |
| intron-3CDS | ENST00000475871 | ENST00000377669 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| intron-3CDS | ENST00000475871 | ENST00000377669 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - |
| intron-5UTR | ENST00000475871 | ENST00000472022 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - |
| intron-5UTR | ENST00000475871 | ENST00000472022 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000377767 | DIS3 | chr13 | 73345933 | - | ENST00000377669 | KLF12 | chr13 | 74420510 | - | 12193 | 1706 | 101 | 2791 | 896 |
| ENST00000377767 | DIS3 | chr13 | 73345933 | - | ENST00000377666 | KLF12 | chr13 | 74420510 | - | 2883 | 1706 | 101 | 2791 | 896 |
| ENST00000377780 | DIS3 | chr13 | 73345933 | - | ENST00000377669 | KLF12 | chr13 | 74420510 | - | 12095 | 1608 | 93 | 2693 | 866 |
| ENST00000377780 | DIS3 | chr13 | 73345933 | - | ENST00000377666 | KLF12 | chr13 | 74420510 | - | 2785 | 1608 | 93 | 2693 | 866 |
| ENST00000377767 | DIS3 | chr13 | 73345932 | - | ENST00000377669 | KLF12 | chr13 | 74420510 | - | 12193 | 1706 | 101 | 2791 | 896 |
| ENST00000377767 | DIS3 | chr13 | 73345932 | - | ENST00000377666 | KLF12 | chr13 | 74420510 | - | 2883 | 1706 | 101 | 2791 | 896 |
| ENST00000377780 | DIS3 | chr13 | 73345932 | - | ENST00000377669 | KLF12 | chr13 | 74420510 | - | 12095 | 1608 | 93 | 2693 | 866 |
| ENST00000377780 | DIS3 | chr13 | 73345932 | - | ENST00000377666 | KLF12 | chr13 | 74420510 | - | 2785 | 1608 | 93 | 2693 | 866 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000377767 | ENST00000377669 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - | 0.000468704 | 0.99953127 |
| ENST00000377767 | ENST00000377666 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - | 0.001368154 | 0.9986318 |
| ENST00000377780 | ENST00000377669 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - | 0.000450351 | 0.99954957 |
| ENST00000377780 | ENST00000377666 | DIS3 | chr13 | 73345933 | - | KLF12 | chr13 | 74420510 | - | 0.001433443 | 0.99856657 |
| ENST00000377767 | ENST00000377669 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - | 0.000468704 | 0.99953127 |
| ENST00000377767 | ENST00000377666 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - | 0.001368154 | 0.9986318 |
| ENST00000377780 | ENST00000377669 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - | 0.000450351 | 0.99954957 |
| ENST00000377780 | ENST00000377666 | DIS3 | chr13 | 73345932 | - | KLF12 | chr13 | 74420510 | - | 0.001433443 | 0.99856657 |
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Fusion Genomic Features for DIS3-KLF12 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for DIS3-KLF12 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:73345933/chr13:74420510) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DIS3 | chr13:73345932 | chr13:74420510 | ENST00000377767 | - | 11 | 21 | 64_182 | 535 | 959.0 | Domain | Note=PINc |
| Hgene | DIS3 | chr13:73345932 | chr13:74420510 | ENST00000377780 | - | 11 | 21 | 64_182 | 505 | 929.0 | Domain | Note=PINc |
| Hgene | DIS3 | chr13:73345933 | chr13:74420510 | ENST00000377767 | - | 11 | 21 | 64_182 | 535 | 959.0 | Domain | Note=PINc |
| Hgene | DIS3 | chr13:73345933 | chr13:74420510 | ENST00000377780 | - | 11 | 21 | 64_182 | 505 | 929.0 | Domain | Note=PINc |
| Tgene | KLF12 | chr13:73345932 | chr13:74420510 | ENST00000377666 | 2 | 8 | 80_88 | 41 | 403.0 | Motif | 9aaTAD%3B inactive | |
| Tgene | KLF12 | chr13:73345932 | chr13:74420510 | ENST00000377669 | 1 | 7 | 80_88 | 41 | 403.0 | Motif | 9aaTAD%3B inactive | |
| Tgene | KLF12 | chr13:73345933 | chr13:74420510 | ENST00000377666 | 2 | 8 | 80_88 | 41 | 403.0 | Motif | 9aaTAD%3B inactive | |
| Tgene | KLF12 | chr13:73345933 | chr13:74420510 | ENST00000377669 | 1 | 7 | 80_88 | 41 | 403.0 | Motif | 9aaTAD%3B inactive | |
| Tgene | KLF12 | chr13:73345932 | chr13:74420510 | ENST00000377666 | 2 | 8 | 317_341 | 41 | 403.0 | Zinc finger | C2H2-type 1 | |
| Tgene | KLF12 | chr13:73345932 | chr13:74420510 | ENST00000377666 | 2 | 8 | 347_371 | 41 | 403.0 | Zinc finger | C2H2-type 2 | |
| Tgene | KLF12 | chr13:73345932 | chr13:74420510 | ENST00000377666 | 2 | 8 | 377_399 | 41 | 403.0 | Zinc finger | C2H2-type 3 | |
| Tgene | KLF12 | chr13:73345932 | chr13:74420510 | ENST00000377669 | 1 | 7 | 317_341 | 41 | 403.0 | Zinc finger | C2H2-type 1 | |
| Tgene | KLF12 | chr13:73345932 | chr13:74420510 | ENST00000377669 | 1 | 7 | 347_371 | 41 | 403.0 | Zinc finger | C2H2-type 2 | |
| Tgene | KLF12 | chr13:73345932 | chr13:74420510 | ENST00000377669 | 1 | 7 | 377_399 | 41 | 403.0 | Zinc finger | C2H2-type 3 | |
| Tgene | KLF12 | chr13:73345933 | chr13:74420510 | ENST00000377666 | 2 | 8 | 317_341 | 41 | 403.0 | Zinc finger | C2H2-type 1 | |
| Tgene | KLF12 | chr13:73345933 | chr13:74420510 | ENST00000377666 | 2 | 8 | 347_371 | 41 | 403.0 | Zinc finger | C2H2-type 2 | |
| Tgene | KLF12 | chr13:73345933 | chr13:74420510 | ENST00000377666 | 2 | 8 | 377_399 | 41 | 403.0 | Zinc finger | C2H2-type 3 | |
| Tgene | KLF12 | chr13:73345933 | chr13:74420510 | ENST00000377669 | 1 | 7 | 317_341 | 41 | 403.0 | Zinc finger | C2H2-type 1 | |
| Tgene | KLF12 | chr13:73345933 | chr13:74420510 | ENST00000377669 | 1 | 7 | 347_371 | 41 | 403.0 | Zinc finger | C2H2-type 2 | |
| Tgene | KLF12 | chr13:73345933 | chr13:74420510 | ENST00000377669 | 1 | 7 | 377_399 | 41 | 403.0 | Zinc finger | C2H2-type 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DIS3-KLF12 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >22898_22898_1_DIS3-KLF12_DIS3_chr13_73345932_ENST00000377767_KLF12_chr13_74420510_ENST00000377666_length(transcript)=2883nt_BP=1706nt GGAATGGAAAGGGAAGAACCTCCGGGGTTAGGCGTATTCTAGATTGACGCCTTTTGCTGGAAGAGCGCTGCTGGGGTTAGGATTCTGCGC GGCGAGGCAAGATGCTCAAGTCCAAGACGTTCTTAAAAAAGACCCGGGCGGGCGGCGTGATGAAGATCGTGCGCGAGCACTACCTGCGAG ACGACATCGGCTGCGGTGCGCCCGGGTGCGCAGCGTGTGGAGGGGCGCACGAGGGGCCGGCCCTGGAGCCGCAGCCCCAGGACCCGGCGA GCAGCGTCTGCCCGCAACCGCACTACTTGCTGCCCGACACTAATGTGTTACTGCACCAGATTGATGTTCTTGAGGACCCTGCCATCAGGA ATGTAATTGTGCTACAAACAGTTCTTCAAGAAGTGAGAAATCGCAGTGCCCCCGTATATAAACGCATCCGAGATGTGACTAATAACCAAG AGAAGCATTTCTATACTTTCACTAATGAGCACCATAGAGAAACCTATGTAGAACAAGAACAGGGAGAAAATGCTAATGACAGGAATGATA GAGCGATTCGAGTAGCAGCAAAATGGTACAATGAACATTTGAAAAAAATGTCAGCAGACAACCAGCTGCAAGTTATCTTCATAACAAATG ACAGGAGAAACAAAGAGAAAGCCATAGAAGAAGGAATACCAGCTTTCACTTGTGAAGAATATGTAAAGAGCCTAACTGCTAACCCCGAAC TCATAGATCGTCTTGCTTGTTTGTCTGAAGAAGGGAATGAAATAGAAAGTGGAAAAATAATATTTTCAGAGCATCTTCCCTTAAGTAAGC TACAGCAAGGCATAAAATCTGGTACATACCTTCAAGGAACATTTAGAGCTAGCAGGGAAAATTACTTGGAAGCTACAGTATGGATTCATG GCGACAATGAAGAAAATAAAGAGATAATCTTACAGGGACTTAAACATTTAAACAGAGCTGTTCACGAAGATATTGTGGCTGTGGAGCTTC TCCCCAAGAGTCAGTGGGTAGCACCATCTTCTGTGGTTTTACATGATGAAGGTCAAAATGAAGAAGATGTGGAGAAAGAAGAAGAGACAG AACGAATGCTTAAGACTGCTGTAAGCGAGAAAATGTTGAAGCCTACAGGTAGAGTTGTAGGAATAATAAAAAGGAATTGGAGACCATATT GTGGCATGCTTTCCAAGTCTGACATTAAGGAGTCAAGAAGACATCTCTTTACACCTGCTGATAAGAGAATCCCTCGAATTCGCATAGAAA CCAGACAGGCTTCCACATTAGAAGGACGGAGAATTATTGTTGCTATTGATGGTTGGCCCAGAAATTCCAGATATCCAAATGGACACTTTG TGAGAAATTTAGGTGATGTTGGAGAGAAAGAGACTGAAACAGAAGTTTTGTTACTTGAACACGATGTTCCCCATCAGCCTTTTTCACAGG CTGTTCTTAGTTTTCTGCCAAAGATGCCCTGGAGCATTACTGAAAAGGACATGAAAAACCGAGAAGACCTGAGGCATCTGTGTATTTGTA GTGTAGACCCACCAGGATGTACTGATATAGACGATGCTCTACATTGTCGAGAACTCGAAAATGGAAATTTGGAGGTTGGTGTTCATATTG CTGATGTGAGCCATTTTATTAGGCCAGGAAATGCCTTGGATCAAGAATCAGCCAGAAGAGGAACAACTGTGTATCTTTGTGAAAAGTCTC CAAACGTCCACAACTATCCCGATATGGAAGCCGTTCCCCTGTTGCTAAATAATGTGAAAGGGGAGCCCCCGGAGGACTCGTTATCTGTAG ATCACTTCCAAACACAAACTGAGCCAGTGGACTTGTCAATAAACAAAGCCAGGACGTCCCCTACTGCCGTTTCATCCTCCCCAGTTTCCA TGACAGCATCTGCCTCCTCACCTTCTTCAACTTCAACCTCTTCATCGTCTTCTAGTCGTCTAGCCTCATCCCCAACTGTTATCACATCAG TATCTTCAGCGTCATCTTCGTCAACAGTATTAACTCCAGGGCCCCTTGTGGCCTCTGCATCTGGTGTTGGAGGCCAGCAGTTTTTGCACA TTATCCATCCCGTACCGCCTTCAAGTCCCATGAATTTACAGTCTAACAAACTGAGTCATGTTCACCGCATCCCCGTGGTGGTACAGTCGG TGCCTGTTGTCTACACAGCTGTAAGGTCACCTGGAAATGTGAACAACACTATTGTCGTGCCGCTTTTGGAGGATGGGAGAGGCCATGGCA AAGCACAAATGGACCCCCGAGGCCTATCTCCCAGACAAAGTAAAAGTGACAGTGATGATGATGACCTGCCAAATGTGACCTTAGATAGCG TTAATGAAACTGGATCTACGGCCCTTTCCATAGCCAGAGCAGTACAAGAGGTACATCCGTCCCCAGTATCAAGGGTCCGGGGCAATCGAA TGAATAATCAAAAGTTTCCTTGTTCAATTTCACCATTTAGTATTGAGAGCACAAGACGCCAGAGACGGTCTGAATCCCCAGACTCCAGAA AACGGCGTATCCACAGATGTGATTTTGAGGGATGCAACAAAGTGTACACAAAAAGTTCTCACCTGAAGGCTCACCGGAGGACACATACAG GAGAGAAACCTTACAAGTGTACCTGGGAAGGCTGCACCTGGAAGTTCGCTCGTTCAGATGAACTGACGAGGCATTACCGCAAACATACGG GAGTGAAGCCATTCAAGTGCGCGGACTGTGATCGCAGCTTTTCCCGGTCAGATCATTTGGCCCTGCACCGCCGGAGGCATATGTTGGTGT GAGGAATGCTACCTGTCCAGCTGAGCGTAAGAGCTGGATCTCTTAGCGGCACCCAATTCAGCAGGGCTGAATCCCCTTCACAGTGTTAAC ACA >22898_22898_1_DIS3-KLF12_DIS3_chr13_73345932_ENST00000377767_KLF12_chr13_74420510_ENST00000377666_length(amino acids)=896AA_BP=535 MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIV LQTVLQEVRNRSAPVYKRIRDVTNNQEKHFYTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRN KEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNE ENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGML SKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLS FLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKSPNVH NYPDMEAVPLLLNNVKGEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPVSMTASASSPSSTSTSSSSSSRLASSPTVITSVSSA SSSSTVLTPGPLVASASGVGGQQFLHIIHPVPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQM DPRGLSPRQSKSDSDDDDLPNVTLDSVNETGSTALSIARAVQEVHPSPVSRVRGNRMNNQKFPCSISPFSIESTRRQRRSESPDSRKRRI HRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV -------------------------------------------------------------- >22898_22898_2_DIS3-KLF12_DIS3_chr13_73345932_ENST00000377767_KLF12_chr13_74420510_ENST00000377669_length(transcript)=12193nt_BP=1706nt GGAATGGAAAGGGAAGAACCTCCGGGGTTAGGCGTATTCTAGATTGACGCCTTTTGCTGGAAGAGCGCTGCTGGGGTTAGGATTCTGCGC GGCGAGGCAAGATGCTCAAGTCCAAGACGTTCTTAAAAAAGACCCGGGCGGGCGGCGTGATGAAGATCGTGCGCGAGCACTACCTGCGAG ACGACATCGGCTGCGGTGCGCCCGGGTGCGCAGCGTGTGGAGGGGCGCACGAGGGGCCGGCCCTGGAGCCGCAGCCCCAGGACCCGGCGA GCAGCGTCTGCCCGCAACCGCACTACTTGCTGCCCGACACTAATGTGTTACTGCACCAGATTGATGTTCTTGAGGACCCTGCCATCAGGA ATGTAATTGTGCTACAAACAGTTCTTCAAGAAGTGAGAAATCGCAGTGCCCCCGTATATAAACGCATCCGAGATGTGACTAATAACCAAG AGAAGCATTTCTATACTTTCACTAATGAGCACCATAGAGAAACCTATGTAGAACAAGAACAGGGAGAAAATGCTAATGACAGGAATGATA GAGCGATTCGAGTAGCAGCAAAATGGTACAATGAACATTTGAAAAAAATGTCAGCAGACAACCAGCTGCAAGTTATCTTCATAACAAATG ACAGGAGAAACAAAGAGAAAGCCATAGAAGAAGGAATACCAGCTTTCACTTGTGAAGAATATGTAAAGAGCCTAACTGCTAACCCCGAAC TCATAGATCGTCTTGCTTGTTTGTCTGAAGAAGGGAATGAAATAGAAAGTGGAAAAATAATATTTTCAGAGCATCTTCCCTTAAGTAAGC TACAGCAAGGCATAAAATCTGGTACATACCTTCAAGGAACATTTAGAGCTAGCAGGGAAAATTACTTGGAAGCTACAGTATGGATTCATG GCGACAATGAAGAAAATAAAGAGATAATCTTACAGGGACTTAAACATTTAAACAGAGCTGTTCACGAAGATATTGTGGCTGTGGAGCTTC TCCCCAAGAGTCAGTGGGTAGCACCATCTTCTGTGGTTTTACATGATGAAGGTCAAAATGAAGAAGATGTGGAGAAAGAAGAAGAGACAG AACGAATGCTTAAGACTGCTGTAAGCGAGAAAATGTTGAAGCCTACAGGTAGAGTTGTAGGAATAATAAAAAGGAATTGGAGACCATATT GTGGCATGCTTTCCAAGTCTGACATTAAGGAGTCAAGAAGACATCTCTTTACACCTGCTGATAAGAGAATCCCTCGAATTCGCATAGAAA CCAGACAGGCTTCCACATTAGAAGGACGGAGAATTATTGTTGCTATTGATGGTTGGCCCAGAAATTCCAGATATCCAAATGGACACTTTG TGAGAAATTTAGGTGATGTTGGAGAGAAAGAGACTGAAACAGAAGTTTTGTTACTTGAACACGATGTTCCCCATCAGCCTTTTTCACAGG CTGTTCTTAGTTTTCTGCCAAAGATGCCCTGGAGCATTACTGAAAAGGACATGAAAAACCGAGAAGACCTGAGGCATCTGTGTATTTGTA GTGTAGACCCACCAGGATGTACTGATATAGACGATGCTCTACATTGTCGAGAACTCGAAAATGGAAATTTGGAGGTTGGTGTTCATATTG CTGATGTGAGCCATTTTATTAGGCCAGGAAATGCCTTGGATCAAGAATCAGCCAGAAGAGGAACAACTGTGTATCTTTGTGAAAAGTCTC CAAACGTCCACAACTATCCCGATATGGAAGCCGTTCCCCTGTTGCTAAATAATGTGAAAGGGGAGCCCCCGGAGGACTCGTTATCTGTAG ATCACTTCCAAACACAAACTGAGCCAGTGGACTTGTCAATAAACAAAGCCAGGACGTCCCCTACTGCCGTTTCATCCTCCCCAGTTTCCA TGACAGCATCTGCCTCCTCACCTTCTTCAACTTCAACCTCTTCATCGTCTTCTAGTCGTCTAGCCTCATCCCCAACTGTTATCACATCAG TATCTTCAGCGTCATCTTCGTCAACAGTATTAACTCCAGGGCCCCTTGTGGCCTCTGCATCTGGTGTTGGAGGCCAGCAGTTTTTGCACA TTATCCATCCCGTACCGCCTTCAAGTCCCATGAATTTACAGTCTAACAAACTGAGTCATGTTCACCGCATCCCCGTGGTGGTACAGTCGG TGCCTGTTGTCTACACAGCTGTAAGGTCACCTGGAAATGTGAACAACACTATTGTCGTGCCGCTTTTGGAGGATGGGAGAGGCCATGGCA AAGCACAAATGGACCCCCGAGGCCTATCTCCCAGACAAAGTAAAAGTGACAGTGATGATGATGACCTGCCAAATGTGACCTTAGATAGCG TTAATGAAACTGGATCTACGGCCCTTTCCATAGCCAGAGCAGTACAAGAGGTACATCCGTCCCCAGTATCAAGGGTCCGGGGCAATCGAA TGAATAATCAAAAGTTTCCTTGTTCAATTTCACCATTTAGTATTGAGAGCACAAGACGCCAGAGACGGTCTGAATCCCCAGACTCCAGAA AACGGCGTATCCACAGATGTGATTTTGAGGGATGCAACAAAGTGTACACAAAAAGTTCTCACCTGAAGGCTCACCGGAGGACACATACAG GAGAGAAACCTTACAAGTGTACCTGGGAAGGCTGCACCTGGAAGTTCGCTCGTTCAGATGAACTGACGAGGCATTACCGCAAACATACGG GAGTGAAGCCATTCAAGTGCGCGGACTGTGATCGCAGCTTTTCCCGGTCAGATCATTTGGCCCTGCACCGCCGGAGGCATATGTTGGTGT GAGGAATGCTACCTGTCCAGCTGAGCGTAAGAGCTGGATCTCTTAGCGGCACCCAATTCAGCAGGGCTGAATCCCCTTCACAGTGTTAAC ACAAAAGGGCATCACCATCCCACGATGTCTGAAACCAGAGCAGGAAAAAGAAGGCACACTTCTTTTGGTCTGAAGGTAACCCCCATCATG ACTAGACGAGAACCGTCTTTACCCGGGCCTGGGAGCTCAGTGACATAAATGCTGAAGAGACAGGCATTGTTTTCCGTGCTGTGTCCTCTG CCATTTAAAGATGTTTGTAGCTTGTACATTTTCTGAGCTGTCAGACATTTTGTTATTGATACCTTAAAGGTCACCTACCACAAATTGATG GCTAGAGCAAGACCTTTTAAATTTGGATGAATCTCCCATCATCCCATCCCTTAACCCCTTTTTACAGAAATTTTAGTTACAATCTGAGTA AGCTAGAACACACATCCAATCTGTTACCAGCAAGCAGCATGAAAGTAGAAACGAAGAAGCAGATGGAGAGGTCCCATTACCTGCAAAGAA AGGGCACTCAGGCAGCCCTTTGCAATCGCGATGGCAGCCACTAGATATCACTCTCAACTTGTCATTCTGCCATGCCCTGAAGAAAACCAA CATTGAATCTTTCATTTGTTTGTCGTTGATTGTTTTTGTTTTGTTTCGATTCTGTTTTGTTCATCTGTTCGAGCAGAGGGGCAGTTGAAG TCTCGTCCTGGTCTCTGCCCTGGCATGGACTGGCACAGAGGTGTTCTGTAGTTGAATAGGAAGAGCCTGTCTAAAAAACTACTGCCCCAC TTCAAATTGCAGTGTTCTGTCACCTAGGCATCATCTCTTCCTGCCCCTAGTATTTGATTACAAGGAACCAGGGGAAAAAAACTTTCTTAG ACACACTGGCACCAAGGTAAGAGGTGGGGCTGCCCAGGCAAAGTCAGTGAACATGAAAACTCAGACAAAGCAGAGATGGAAATAATGCGC CTCTTGAGGAGAAAAGCAATAATGAATAAAAGGACTTTCCTACAATAACTTCACTGAGGACTCACGTTACCAATTTTCATACTTACTAAA GGGATTGTAAAAAACACCCCAGCATTTTAGGTGTCTTGGTTCCATTTACAGCACTGAGGTAATCTTTCTGCTGTTTGTTGTCCTGCTTGG TTGAGTACCACAATTAAAGATTATGCTCCCCTTTTCTTGTTTGAAAACAGTTATTTGGTGACTAGAAAGGCAAGGGAGGCATAGCCGGGA ATTAACTCTTCGGTTAATGGGTCAGTTCTCCTTGGAACTGAATCAGTGGAAAGAGAATGCTTCCCATAGAAAGCCCGACATGGTGCTAGT TTCCTCTCTTGGAGAGCCAAGGATAAGTGACTCTCCAATAGGTTCTTCTATACCGATTTCATTTTCTAAACTGTATCAGGACCCAGGTGT CCTGCATTGGCATCTGCAGGGATATTGAACCCACTCATCCTGTGCAGAGGATGAGAGGAAGGTGTTAGTTCCATCAGCCCCATAAAATTA TGAACCTTTTTGCAACTAGGAACATATACAGTAAACAAGCAATACATCACCAACGAGCATTCTTTCAGAAAAATTACCATATTTTTGTCC CCACCACAAGCTGGGTTTTTTTCCAGCTTTCTGTGGCTGAGGGGCTGGTGAGATTTTTTGTTGTTATTGTTGTTGTTGCTAGAATTTTTT ATAGCTTAGATATAAAAGGTCTCCAACAAAGACCTTTGCAATATATTTTAATTACAAACACTTGATTTTGGGAATTGCACATATTAACCT CACAATATTACTAGCTCATTTTTAAATGTCTGGACATTCTGAAATAATTTCCGGTTACAGAATTACCCTTTTTAGGATCATCTTCTAATT CAGATAATCTTATTCTGATGAAGCGAGAACTATGAACGTTGAAACAAGGACAATTTGTGTTGGATGGTATTCAAAAGGAATTTTTTAAAA CATTAAGCAACAGTGTAATGATTTTCAGGTCAAATTATGGCTTCACAAATATGTGCTCTATATTGTCTGCCAGGTCTCAAAAATTCATCA AGCAATTTCCCTCCAACAAGGGCTGCAGTTCTAGTGATAAATAGCATCTTTAGCTGCACAGTCTACTACTCATCAACCAGTGGGTTTTTT TTAGCACCTGGAAAGTTTTTTTGTACTATATGCAACTCCTACTTCACATTGCCTGTGACCATTCAGAATAGAAAAAGGTCTGTTGATGCA TGCCAGTGCTGGTTACTAGTCAGTGACAGAGAACACAGAGAGGGACAAACACAGCCATGAACCCCCTGGCACTAGTACCAGCACCTAGTT GGCAAGTAGTGGGTGCATCTCTCAAGTGAAGTGTAGATTTGTATTTAGTCCTGCTTGCTCTCATAAAAAGAGCCAGTTCTTTTCTCTGCT GAAAGATGTCTTGAGAGTATTACAGGTAGACTTGGTTTTTAGAATTCATAAAACTGACAGGCAGGGGAATCTTCCTGAGTGACAGCTTGG TTTAAATTTAGCACAGAACTAGATGAGTTGCACTTTTCTAATAACATAGGATGGATTTGGGGAAGGGAACATTTTCCCTCATCCTCTGAA AGTGGAAACCAGACTGAGATGGTAAGTTAACTGATAAAACCTGTCAGCATTCCATCATTTTCCCCTTTTGACGTATCAGTACTTCTAAGA AGGGATCTAAGCACAATTAAGTGAATTGAGTCCCTGGTCTAGCCTCAGGAACTGAAACTTCTTTGGGGCTTGTCTTGAGACGTGGCAAAT TCTCCTTGGTGAGTTTTCTAAAAGTATTTCCCCATGGAAAGGAGAAAGTGGTTTGGGACAGAAAGAAATGGAATGTCTTCAGTCATGGAA GAGCCTCCATTTCATCTCATGTCCATTTCTAGCCTCTTTCAAAAAGCACAGTGCATCATGAGCAACAGAAAAGCAGTAGAATCCTAAAGG ACATAACAGTTGTTCCGTAACTAGAAGCATTCTTTGATTTTAAATTTGAAGCTGTTCAGTTTGCAGCTGGGGATATGTGCATGGTTGGGA ACTTATACACATAGAGCCATTAACTACTTAAGCAGCTGCAGTAGACCTGATTTTCTGTTTGCAGTATAGAGATTGATTTCAAGGGAGTTA CATTATTTGAAAAGTTATGACTTTCAGCCTTTGAGGTTTTAAGAATCCCTTTTCATGGTCTGATCTTAAGTTGTTTGAAAAAAGATTCAC GCTTCTGCATCCACCTCTGCCCTCATTCTGTCAATTGTGTGTGGACTCTGAGAAGCCTGCTTGATAACTTGTCTTAAGTTCTATTAAGGC AGTTAGACTGAGATTTCTAATGACTTCACCATAAAGATTATACTTCTGCCTGGCGTCGTTTCTATAAAACACTATAGGACATTTGTTTTC AAAAGCAGTTGAGTAACAGCAACATAAACCACATTTTTTAAAAAAATGAGCACTTTTCATTCACTTGAAAGCTTAAGTGGGAAAAAGGAA GATGATTGTCAGGGGAAAAACTTACAAAATGCTACAGTGTTTACAAATGCCAGTTCCAGGTGATTAGAAAGGCCGTTTTCATTATGGTTC AGATTTGGAATAGCTTATGCAAAGATTGTGTTCATTTTTATACAATTCTTTTTAACTTTAAATTGCCATCTGTGTTTTAAACATAATTCT GCACTTTGGAATCAGTTCATTAGAATGATAACATTTATATGGATAAAGATGCAGTATTCCTTATTCTGTACTTGATTTATTATACTTACC AAAGCTGCAACTGAATAAATCTGGTGAGGTGAGGCCTTCAAAATGTATTAATACGCCTTTGTTATGTTGTTATGACTGCTTAGAAATGTA GCCATGATGTTGTTCTAAAGATGTCTTAACATTTATAGTGAGGATTGACAGAAATTAAGCAGTGTTAAGAATACCAGCATCCATGTTACA GTCTGCGTATAAGGGACTGAATGTGAGGTAACTCTTATGAATCATAATAGGCCCAGAAAGCCTTAATATTCATAGTTCATAATCCAGTCT CAGATTTTGCTCTTCAATGTTGCCTGTAAACTTAGCAGGTAAATGTATTCTAGTATAAAACATCATTGACCAAATCTCTTCCTTTAGTTT TTCTGAGGTAGTGCATCCCATTAAAAAAGTCTCTTCAATTAGATTTGGCTTTAGTTTAGAAAGGGGTTTGGTAAGTCATGTCTTCCATAT GACATTTCTACTCATCCCCACACTGCCTTCCACTTAACCTGTACAGACAGCCCCAACACATGCACATGTGTGTACACAACTGTATATGCA GCAGCCAGTGGGCTAACAAATATCAGCAAAGAACTTTTTTAAAAAGAATTTGTAATAATCCGTGCTGTCTAGAAATGTGAGTTACTTACC TTATTAGGAAACCGGCTTATAATACTATATATGACTCTGCCTGCATTTTATAGTTAAGAAATGTACATAAAAATTGCTATATTTTCACAG TTTCATTATAATGTCTGTTTAGTAACCCATGTCCACTGATACTTTAAATATGCTAATTACTGAGCAATTGCAATAGAAATCCAGATTTTC ATAAGAAAATGAAATAGAAGGATACTGCATCTTTAAAAAATAGAGTGAAGATATTTTACTGTATTCGTAACATATGTGATAGTGGAAAAA GTATTTTCAAACTCACAAATTTTACAGAGGTTGTAAATAGTTTGATGAAGTATGTTGGGAAAGAGAGCTTCTAGTTTTCATCACAATAAA AAGAAAAAACTTGTTCAGATATGCCTTGTATATCTTACACACAATGAGTGAAATTGCCATGGGAACTCTGTCCAACTTTGTCAGAGCATG CTCTTCGTGTTCTGTTCAAAATAGAGTGGCCACTTGTCATGGTTTAGCCAGGATGGTTTAAAATATAATGAAGTCATTTTAAGTTGCAGA CAACTGATTCCAAACTAGTAATGTCTTTTCCTGAAAAGGGCAAAACAGCTGCACAGGATTTTGCTTGTACTAAAGAGGAGCATCTTACAA TTGTTCTCTTTTCTCAGTTATCTCCCTCCTCAACAGAGTGTGAACAACCATACAGGTGTTTATTCTTGTTTTATTCCAGGGAGACTGCTT TTAGGTATAACTACATGTTGACAAGATTAAGTGCTGTGGATATGGCCACGTGTTAAAGGAATCTATACTCGCAATAGGAATAAGCTAATG CCCATTTTCAGAAATAAATTAAATGCTGAAAGTGCCTGTCAGTAAACCTTATGACCAATGAGATATTCCTATACTTTTACACAGCAATAA TTCTTAATAAGACTGGGTTTTTTCCTGCACATGTGAACACACACACACATACACACAGAGAGAGTAAATACATACACATAGTAAATCAAA TCTGTTCACATGCCCACAAAAAACGCTTTTATAGCTTTCAAATATACCTAATCTTGTTTACATTAACATTTCTTAATTTGATCTTTCTAA CTTGCAGAACGTTAAGAACACAAATCTGAACATTAAGTTTATCTTCAGTGAACACTATTGCATATGGTAATTATAATTTCCAGATAAAAA GTTGACTGTCATTTGCCCCAAACTTATGAAACAGTATGTATGATTCAAAAAGTTTTGCTCAGTTAAAAACACCAATTTATTTGGCGCAAA AGACTGAAGGATATTTGTTTGCTTGTTCATTTTATCCACTCATATCAAACGCACAAATTCATCTTTACATTTCTTCATTCCCCTTTCCCC TAATATTTCCTATTATCATCTTAAGAATCATTTTGGAATGAATATTGACAGAATCATTTCTCCCCAAAAAGTCTGTTGAAGTACCACTGA CACTTAGTAAGCCTAGCCTTTAACCATCTTTGCAGTTAGTCCTAAAAATTACCAGATGCACATTCAGAAGCTCACAGGTTTTTTCCTGTA ATTACTGTACTGCTAAAAGTGGAGTCATGGATAGAAATATACAATGAGACTATATGAATAGACATGAACCCTGGAAATTCTCCAACCCTG CCATCTCAGAGCACAAATTCACCCAAACAAGCTACTGAGGCTATCAGTAAAATTATACTCATGGAGAGTCACACATCGGGTAAGGGCAAT TTTAAAAGTAGGACTGTGATTAAACATTCAGGCTTTAGACTTCCATGATGGACTCAGACCACAGGCCTCAAAAAAACATCCACTGTTTTC TCCTCCCAATGTTAGAAAGAAGAAAAGGGAGACGGAAATGTACCAGGATAAGGGGGTAAAATAACCAATTAAGTGTCAAAGGAAAGCTGC TGGGTTCCTTAATCTCACTGAAGTCAAGTCTTCTGACTGGGCTTCTTACCATGTGTTGTCTGAAAAAACTAAAGTACCTTGAAAGGTTAC ACATTCAGCAAACCATGAAGATAATAGCTATTCTTTATTAAACACTGTGTGCCAAGCAATAGACTAGGCAATTTTTAGATACGTTACCTG CAACCTGTACAACATTTCTACACTTTATGGATGGGAAACGGAGACATGGGAAGTGTGGCTGAGTTGTTCATGGATGTAGAAATAGTAAAC GGCAGAGTAGGAAAGTGAAACCGCCTATCTCTGACCTGGAGGTCTGCCTGTATCTTTCCCACTCCACCACACTGCACGTGGGTGTCCCGA AACCACCTTCCCAGATTCCTGACTCTCAGTAATTTTATTATGGACAACATGCATGAGTAGTCATCATATTTTTCAAGTGAAATATCGGGA CATGATATAACACATGACTTAACAATGGTACTGAATATTTGAAATCAGGCCTTTCCCGGAAAATCATGCATGAAGGATCATTATAAACAA ACAATAGCAACCAGTTGTCTCCCCGAACTTGTCACTTTTCTCATAAATGTCTGGCCTGGAGCTCCAAAATCATCCAAATACTTAGTAGCA TTTTAGCCTGAGTACACTTTCTCAGTTCCTCAACTCTTTGTATACCTTTCCACCAATATAGACATTCTAGAATCTGCTTCAGATGCATTT GAAATTTTCACCCCCATGGAACTAGTGATTAATATCAGAGCCCACTCTTGCAGTTGGTAATGGGGTGGCAATCAAACGTTCAGATGATGA TAAAGGAGAGATAATGGATAATTCTTTTTCAGAGTTCTCACTTAACAGCTCTGTTGTGGAATGTTTTAAATAGTCTTATAAATAATTTGT TTATAGTATTGTTGTTAGTTTAATTGAATTTTATGTAAGAAGCTGTCCAACATCAGAGAAATGAAATTCCTCCCACTTTCTGTGTAGAAC AAGGTCTCTGACAGTATTGATTCATGGAAGTACTAATGGACTTAGAAAACATTAAGAGAATGTCATTTCTCATAGTGTTTCTGTTTCTGA AAATGAATCTCCTGAATTATTATCTTTCTCCCTGTTACTTGGCTGGGGAAAGAGATAGAAGCTGTATAAACAAATTCTCTTCCATGCTCA AAGCAAGTGTTCCATGTGCACAACCTGCTGCAGACTGGGGCCCTTCTCAGTTAATTGGGTTTCACAAGCAATAATTTCTCCACAACAAAA ACCACAACTTGAAGTGAGTTGAAAAGAGATCAATAGTGGAAACAGTCGCCTCAGTACTTTTTCTTTCTGGATTTCATCTCTAGAAATTTG AAGTGTTTGAGACAGAGTCCACCCTTTGTGCAAGGCGAGAACCAATGAATGGACTCCTTGTGTGAATTATTGCATCTTCTTCCAAAGCAG GTTCATCAAGACTTTCACAGAGATTCATTTTTGTTGAGAAGTAAGGGTTAATAGGAGGATAGAATTTGGATCCAAATCTAGTGATAAAAG TGTCCAAGCAATCAAAAAGTAAGATATTTTAGGGACATACCAACATCTTCCCTTTCTGCTAATTTCATGCTCCAAAGATATGGCAAAAAA AAAAATCATAAAAAGTGCTTTTGCCCTACTTGTGTTCTAGTTTTCCCATGGCAGAATTTTGTAATTACATCCAGAATATAGTGTATATTT TGTTCCTCAAACTTTATTACATTGGATGGATATTGTTGAACTGGGGCACTGGTGCCTATATTCAAGGCTCTTTCCTATCAACGTGTCTGT CCACGATTTGTTGTGTTTAAAGCTTCATTTTGAAAAATCACTGTCCCCCTGTGGGGTAGTGACTGTATTGTTTTGTTCATGTCTATGTGG GACACATTGCATCACATGGCAAACCAACTCTCTGTGGATGTGAGATAAGTACTTATAAAACCAGCTTGAAAACATCGTCTTATGTATTAT GTCATCCTGCATCATAATGCAATTATGTGTATCATAACATGCTCATTTAAAAAAAGAGAAACCAGCAAATTCATGTTTGTCCATAGAAGA ATGTACTCAGAACTTTGTGTTGTGAAACGATGAGAACAGACCACCTTTAAGATACCCACCTGCCACTTAAAATGACTTAGTTATAATTAG TAGTAGTCTAGACGTTGTTCTTGGTGTGTGGGGGTCAATTCTAACGTCATGTTCTTTTGAATAAATCTCTCAGTCATATTTGAAAAAAAA ATACATGGGAATAAAGAAAAATATCATCTTTGGCCAAATCAAGCAGGCATCTTTTTTCTTTTCCTTGACGTTTAGCTCATTATACGTGGT GATTGGATCACGAGATCTGTCCGTGTGAAAATACAGAAACATCCTTTAGTTTACAAAACAGTTATTCTAGGCTTGAAGCCTCTGAACAGC AAATTGAATAGATGGGCTGCATCTGATTTGCTTTATGGATGTAATTTTACAAAACACTCTTGGGTCTCTGACCCCAGGGAGTTAAGAGTG CCCAGAGGAGGTCCTACACATTAAAGGATAAAGCCCCCCAGTGATGCTGGCAAGCAAATGTGTTGAGTTCTTAAATCTTCATTTGGTTTT CTGTTCAGGATTTTAATTGCAAATGAATTTATTTCTCCAGTTTATCTAAAGACCTAATTTCCCAATAGTTTCCTCTGCATTTATATACTC TGTAGTGTTTAGGCAACCCTGTTATAAGTTTATTAATATTATGTAAGTGTTGTTCTTGTATTTATGTATAGTGTATGTATTGTAAATATA CTCAGAGCTTTTTTCCTTTTACTGTAAAATGGTGATTTTTTTGCCCTATGATAATGTAAAGGGAGACCCTCCTAATGAGATTCTCTCAGA GGATGATTATTCCAGTCTATTCTCAGAGATTTAAATGAACAAGTGTTATTGTTTTTAATGGTGTCTCAGACATATTCTGTTGGTGCATTG CTTTTCTGTATTCAACTTTCCTATGAATTGAGCTGTGAACTGAAATAGAGTTTAAACCTTTAACTGTATGCATTTGTATAATTATCTGAA TGAAGGCATGAAGGTTAAATAAAGCATTTTGTATGGAACAAAA >22898_22898_2_DIS3-KLF12_DIS3_chr13_73345932_ENST00000377767_KLF12_chr13_74420510_ENST00000377669_length(amino acids)=896AA_BP=535 MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIV LQTVLQEVRNRSAPVYKRIRDVTNNQEKHFYTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRN KEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNE ENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGML SKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLS FLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKSPNVH NYPDMEAVPLLLNNVKGEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPVSMTASASSPSSTSTSSSSSSRLASSPTVITSVSSA SSSSTVLTPGPLVASASGVGGQQFLHIIHPVPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQM DPRGLSPRQSKSDSDDDDLPNVTLDSVNETGSTALSIARAVQEVHPSPVSRVRGNRMNNQKFPCSISPFSIESTRRQRRSESPDSRKRRI HRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV -------------------------------------------------------------- >22898_22898_3_DIS3-KLF12_DIS3_chr13_73345932_ENST00000377780_KLF12_chr13_74420510_ENST00000377666_length(transcript)=2785nt_BP=1608nt AAGGGAAGAACCTCCGGGGTTAGGCGTATTCTAGATTGACGCCTTTTGCTGGAAGAGCGCTGCTGGGGTTAGGATTCTGCGCGGCGAGGC AAGATGCTCAAGTCCAAGACGTTCTTAAAAAAGACCCGGGCGGGCGGCGTGATGAAGATCGTGCGCGAGCACTACCTGCGAGACGACATC GGCTGCGGTGCGCCCGGGTGCGCAGCGTGTGGAGGGGCGCACGAGGGGCCGGCCCTGGAGCCGCAGCCCCAGGACCCGGCGAGCAGCGTC TGCCCGCAACCGCACTACTTGCTGCCCGACACTAATGTGTTACTGCACCAGATTGTAAGTGCCTGGAGGCCGGGGACCTGGGCTTCTGTG GCCTCCAGCCTGCGACTCCCAGGCAGCTTAGAAACCTATGTAGAACAAGAACAGGGAGAAAATGCTAATGACAGGAATGATAGAGCGATT CGAGTAGCAGCAAAATGGTACAATGAACATTTGAAAAAAATGTCAGCAGACAACCAGCTGCAAGTTATCTTCATAACAAATGACAGGAGA AACAAAGAGAAAGCCATAGAAGAAGGAATACCAGCTTTCACTTGTGAAGAATATGTAAAGAGCCTAACTGCTAACCCCGAACTCATAGAT CGTCTTGCTTGTTTGTCTGAAGAAGGGAATGAAATAGAAAGTGGAAAAATAATATTTTCAGAGCATCTTCCCTTAAGTAAGCTACAGCAA GGCATAAAATCTGGTACATACCTTCAAGGAACATTTAGAGCTAGCAGGGAAAATTACTTGGAAGCTACAGTATGGATTCATGGCGACAAT GAAGAAAATAAAGAGATAATCTTACAGGGACTTAAACATTTAAACAGAGCTGTTCACGAAGATATTGTGGCTGTGGAGCTTCTCCCCAAG AGTCAGTGGGTAGCACCATCTTCTGTGGTTTTACATGATGAAGGTCAAAATGAAGAAGATGTGGAGAAAGAAGAAGAGACAGAACGAATG CTTAAGACTGCTGTAAGCGAGAAAATGTTGAAGCCTACAGGTAGAGTTGTAGGAATAATAAAAAGGAATTGGAGACCATATTGTGGCATG CTTTCCAAGTCTGACATTAAGGAGTCAAGAAGACATCTCTTTACACCTGCTGATAAGAGAATCCCTCGAATTCGCATAGAAACCAGACAG GCTTCCACATTAGAAGGACGGAGAATTATTGTTGCTATTGATGGTTGGCCCAGAAATTCCAGATATCCAAATGGACACTTTGTGAGAAAT TTAGGTGATGTTGGAGAGAAAGAGACTGAAACAGAAGTTTTGTTACTTGAACACGATGTTCCCCATCAGCCTTTTTCACAGGCTGTTCTT AGTTTTCTGCCAAAGATGCCCTGGAGCATTACTGAAAAGGACATGAAAAACCGAGAAGACCTGAGGCATCTGTGTATTTGTAGTGTAGAC CCACCAGGATGTACTGATATAGACGATGCTCTACATTGTCGAGAACTCGAAAATGGAAATTTGGAGGTTGGTGTTCATATTGCTGATGTG AGCCATTTTATTAGGCCAGGAAATGCCTTGGATCAAGAATCAGCCAGAAGAGGAACAACTGTGTATCTTTGTGAAAAGTCTCCAAACGTC CACAACTATCCCGATATGGAAGCCGTTCCCCTGTTGCTAAATAATGTGAAAGGGGAGCCCCCGGAGGACTCGTTATCTGTAGATCACTTC CAAACACAAACTGAGCCAGTGGACTTGTCAATAAACAAAGCCAGGACGTCCCCTACTGCCGTTTCATCCTCCCCAGTTTCCATGACAGCA TCTGCCTCCTCACCTTCTTCAACTTCAACCTCTTCATCGTCTTCTAGTCGTCTAGCCTCATCCCCAACTGTTATCACATCAGTATCTTCA GCGTCATCTTCGTCAACAGTATTAACTCCAGGGCCCCTTGTGGCCTCTGCATCTGGTGTTGGAGGCCAGCAGTTTTTGCACATTATCCAT CCCGTACCGCCTTCAAGTCCCATGAATTTACAGTCTAACAAACTGAGTCATGTTCACCGCATCCCCGTGGTGGTACAGTCGGTGCCTGTT GTCTACACAGCTGTAAGGTCACCTGGAAATGTGAACAACACTATTGTCGTGCCGCTTTTGGAGGATGGGAGAGGCCATGGCAAAGCACAA ATGGACCCCCGAGGCCTATCTCCCAGACAAAGTAAAAGTGACAGTGATGATGATGACCTGCCAAATGTGACCTTAGATAGCGTTAATGAA ACTGGATCTACGGCCCTTTCCATAGCCAGAGCAGTACAAGAGGTACATCCGTCCCCAGTATCAAGGGTCCGGGGCAATCGAATGAATAAT CAAAAGTTTCCTTGTTCAATTTCACCATTTAGTATTGAGAGCACAAGACGCCAGAGACGGTCTGAATCCCCAGACTCCAGAAAACGGCGT ATCCACAGATGTGATTTTGAGGGATGCAACAAAGTGTACACAAAAAGTTCTCACCTGAAGGCTCACCGGAGGACACATACAGGAGAGAAA CCTTACAAGTGTACCTGGGAAGGCTGCACCTGGAAGTTCGCTCGTTCAGATGAACTGACGAGGCATTACCGCAAACATACGGGAGTGAAG CCATTCAAGTGCGCGGACTGTGATCGCAGCTTTTCCCGGTCAGATCATTTGGCCCTGCACCGCCGGAGGCATATGTTGGTGTGAGGAATG CTACCTGTCCAGCTGAGCGTAAGAGCTGGATCTCTTAGCGGCACCCAATTCAGCAGGGCTGAATCCCCTTCACAGTGTTAACACA >22898_22898_3_DIS3-KLF12_DIS3_chr13_73345932_ENST00000377780_KLF12_chr13_74420510_ENST00000377666_length(amino acids)=866AA_BP=505 MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIVSAWRPGTWASVA SSLRLPGSLETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDR LACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKS QWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQA STLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDP PGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKSPNVHNYPDMEAVPLLLNNVKGEPPEDSLSVDHFQ TQTEPVDLSINKARTSPTAVSSSPVSMTASASSPSSTSTSSSSSSRLASSPTVITSVSSASSSSTVLTPGPLVASASGVGGQQFLHIIHP VPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQMDPRGLSPRQSKSDSDDDDLPNVTLDSVNET GSTALSIARAVQEVHPSPVSRVRGNRMNNQKFPCSISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKP YKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV -------------------------------------------------------------- >22898_22898_4_DIS3-KLF12_DIS3_chr13_73345932_ENST00000377780_KLF12_chr13_74420510_ENST00000377669_length(transcript)=12095nt_BP=1608nt AAGGGAAGAACCTCCGGGGTTAGGCGTATTCTAGATTGACGCCTTTTGCTGGAAGAGCGCTGCTGGGGTTAGGATTCTGCGCGGCGAGGC AAGATGCTCAAGTCCAAGACGTTCTTAAAAAAGACCCGGGCGGGCGGCGTGATGAAGATCGTGCGCGAGCACTACCTGCGAGACGACATC GGCTGCGGTGCGCCCGGGTGCGCAGCGTGTGGAGGGGCGCACGAGGGGCCGGCCCTGGAGCCGCAGCCCCAGGACCCGGCGAGCAGCGTC TGCCCGCAACCGCACTACTTGCTGCCCGACACTAATGTGTTACTGCACCAGATTGTAAGTGCCTGGAGGCCGGGGACCTGGGCTTCTGTG GCCTCCAGCCTGCGACTCCCAGGCAGCTTAGAAACCTATGTAGAACAAGAACAGGGAGAAAATGCTAATGACAGGAATGATAGAGCGATT CGAGTAGCAGCAAAATGGTACAATGAACATTTGAAAAAAATGTCAGCAGACAACCAGCTGCAAGTTATCTTCATAACAAATGACAGGAGA AACAAAGAGAAAGCCATAGAAGAAGGAATACCAGCTTTCACTTGTGAAGAATATGTAAAGAGCCTAACTGCTAACCCCGAACTCATAGAT CGTCTTGCTTGTTTGTCTGAAGAAGGGAATGAAATAGAAAGTGGAAAAATAATATTTTCAGAGCATCTTCCCTTAAGTAAGCTACAGCAA GGCATAAAATCTGGTACATACCTTCAAGGAACATTTAGAGCTAGCAGGGAAAATTACTTGGAAGCTACAGTATGGATTCATGGCGACAAT GAAGAAAATAAAGAGATAATCTTACAGGGACTTAAACATTTAAACAGAGCTGTTCACGAAGATATTGTGGCTGTGGAGCTTCTCCCCAAG AGTCAGTGGGTAGCACCATCTTCTGTGGTTTTACATGATGAAGGTCAAAATGAAGAAGATGTGGAGAAAGAAGAAGAGACAGAACGAATG CTTAAGACTGCTGTAAGCGAGAAAATGTTGAAGCCTACAGGTAGAGTTGTAGGAATAATAAAAAGGAATTGGAGACCATATTGTGGCATG CTTTCCAAGTCTGACATTAAGGAGTCAAGAAGACATCTCTTTACACCTGCTGATAAGAGAATCCCTCGAATTCGCATAGAAACCAGACAG GCTTCCACATTAGAAGGACGGAGAATTATTGTTGCTATTGATGGTTGGCCCAGAAATTCCAGATATCCAAATGGACACTTTGTGAGAAAT TTAGGTGATGTTGGAGAGAAAGAGACTGAAACAGAAGTTTTGTTACTTGAACACGATGTTCCCCATCAGCCTTTTTCACAGGCTGTTCTT AGTTTTCTGCCAAAGATGCCCTGGAGCATTACTGAAAAGGACATGAAAAACCGAGAAGACCTGAGGCATCTGTGTATTTGTAGTGTAGAC CCACCAGGATGTACTGATATAGACGATGCTCTACATTGTCGAGAACTCGAAAATGGAAATTTGGAGGTTGGTGTTCATATTGCTGATGTG AGCCATTTTATTAGGCCAGGAAATGCCTTGGATCAAGAATCAGCCAGAAGAGGAACAACTGTGTATCTTTGTGAAAAGTCTCCAAACGTC CACAACTATCCCGATATGGAAGCCGTTCCCCTGTTGCTAAATAATGTGAAAGGGGAGCCCCCGGAGGACTCGTTATCTGTAGATCACTTC CAAACACAAACTGAGCCAGTGGACTTGTCAATAAACAAAGCCAGGACGTCCCCTACTGCCGTTTCATCCTCCCCAGTTTCCATGACAGCA TCTGCCTCCTCACCTTCTTCAACTTCAACCTCTTCATCGTCTTCTAGTCGTCTAGCCTCATCCCCAACTGTTATCACATCAGTATCTTCA GCGTCATCTTCGTCAACAGTATTAACTCCAGGGCCCCTTGTGGCCTCTGCATCTGGTGTTGGAGGCCAGCAGTTTTTGCACATTATCCAT CCCGTACCGCCTTCAAGTCCCATGAATTTACAGTCTAACAAACTGAGTCATGTTCACCGCATCCCCGTGGTGGTACAGTCGGTGCCTGTT GTCTACACAGCTGTAAGGTCACCTGGAAATGTGAACAACACTATTGTCGTGCCGCTTTTGGAGGATGGGAGAGGCCATGGCAAAGCACAA ATGGACCCCCGAGGCCTATCTCCCAGACAAAGTAAAAGTGACAGTGATGATGATGACCTGCCAAATGTGACCTTAGATAGCGTTAATGAA ACTGGATCTACGGCCCTTTCCATAGCCAGAGCAGTACAAGAGGTACATCCGTCCCCAGTATCAAGGGTCCGGGGCAATCGAATGAATAAT CAAAAGTTTCCTTGTTCAATTTCACCATTTAGTATTGAGAGCACAAGACGCCAGAGACGGTCTGAATCCCCAGACTCCAGAAAACGGCGT ATCCACAGATGTGATTTTGAGGGATGCAACAAAGTGTACACAAAAAGTTCTCACCTGAAGGCTCACCGGAGGACACATACAGGAGAGAAA CCTTACAAGTGTACCTGGGAAGGCTGCACCTGGAAGTTCGCTCGTTCAGATGAACTGACGAGGCATTACCGCAAACATACGGGAGTGAAG CCATTCAAGTGCGCGGACTGTGATCGCAGCTTTTCCCGGTCAGATCATTTGGCCCTGCACCGCCGGAGGCATATGTTGGTGTGAGGAATG CTACCTGTCCAGCTGAGCGTAAGAGCTGGATCTCTTAGCGGCACCCAATTCAGCAGGGCTGAATCCCCTTCACAGTGTTAACACAAAAGG GCATCACCATCCCACGATGTCTGAAACCAGAGCAGGAAAAAGAAGGCACACTTCTTTTGGTCTGAAGGTAACCCCCATCATGACTAGACG AGAACCGTCTTTACCCGGGCCTGGGAGCTCAGTGACATAAATGCTGAAGAGACAGGCATTGTTTTCCGTGCTGTGTCCTCTGCCATTTAA AGATGTTTGTAGCTTGTACATTTTCTGAGCTGTCAGACATTTTGTTATTGATACCTTAAAGGTCACCTACCACAAATTGATGGCTAGAGC AAGACCTTTTAAATTTGGATGAATCTCCCATCATCCCATCCCTTAACCCCTTTTTACAGAAATTTTAGTTACAATCTGAGTAAGCTAGAA CACACATCCAATCTGTTACCAGCAAGCAGCATGAAAGTAGAAACGAAGAAGCAGATGGAGAGGTCCCATTACCTGCAAAGAAAGGGCACT CAGGCAGCCCTTTGCAATCGCGATGGCAGCCACTAGATATCACTCTCAACTTGTCATTCTGCCATGCCCTGAAGAAAACCAACATTGAAT CTTTCATTTGTTTGTCGTTGATTGTTTTTGTTTTGTTTCGATTCTGTTTTGTTCATCTGTTCGAGCAGAGGGGCAGTTGAAGTCTCGTCC TGGTCTCTGCCCTGGCATGGACTGGCACAGAGGTGTTCTGTAGTTGAATAGGAAGAGCCTGTCTAAAAAACTACTGCCCCACTTCAAATT GCAGTGTTCTGTCACCTAGGCATCATCTCTTCCTGCCCCTAGTATTTGATTACAAGGAACCAGGGGAAAAAAACTTTCTTAGACACACTG GCACCAAGGTAAGAGGTGGGGCTGCCCAGGCAAAGTCAGTGAACATGAAAACTCAGACAAAGCAGAGATGGAAATAATGCGCCTCTTGAG GAGAAAAGCAATAATGAATAAAAGGACTTTCCTACAATAACTTCACTGAGGACTCACGTTACCAATTTTCATACTTACTAAAGGGATTGT AAAAAACACCCCAGCATTTTAGGTGTCTTGGTTCCATTTACAGCACTGAGGTAATCTTTCTGCTGTTTGTTGTCCTGCTTGGTTGAGTAC CACAATTAAAGATTATGCTCCCCTTTTCTTGTTTGAAAACAGTTATTTGGTGACTAGAAAGGCAAGGGAGGCATAGCCGGGAATTAACTC TTCGGTTAATGGGTCAGTTCTCCTTGGAACTGAATCAGTGGAAAGAGAATGCTTCCCATAGAAAGCCCGACATGGTGCTAGTTTCCTCTC TTGGAGAGCCAAGGATAAGTGACTCTCCAATAGGTTCTTCTATACCGATTTCATTTTCTAAACTGTATCAGGACCCAGGTGTCCTGCATT GGCATCTGCAGGGATATTGAACCCACTCATCCTGTGCAGAGGATGAGAGGAAGGTGTTAGTTCCATCAGCCCCATAAAATTATGAACCTT TTTGCAACTAGGAACATATACAGTAAACAAGCAATACATCACCAACGAGCATTCTTTCAGAAAAATTACCATATTTTTGTCCCCACCACA AGCTGGGTTTTTTTCCAGCTTTCTGTGGCTGAGGGGCTGGTGAGATTTTTTGTTGTTATTGTTGTTGTTGCTAGAATTTTTTATAGCTTA GATATAAAAGGTCTCCAACAAAGACCTTTGCAATATATTTTAATTACAAACACTTGATTTTGGGAATTGCACATATTAACCTCACAATAT TACTAGCTCATTTTTAAATGTCTGGACATTCTGAAATAATTTCCGGTTACAGAATTACCCTTTTTAGGATCATCTTCTAATTCAGATAAT CTTATTCTGATGAAGCGAGAACTATGAACGTTGAAACAAGGACAATTTGTGTTGGATGGTATTCAAAAGGAATTTTTTAAAACATTAAGC AACAGTGTAATGATTTTCAGGTCAAATTATGGCTTCACAAATATGTGCTCTATATTGTCTGCCAGGTCTCAAAAATTCATCAAGCAATTT CCCTCCAACAAGGGCTGCAGTTCTAGTGATAAATAGCATCTTTAGCTGCACAGTCTACTACTCATCAACCAGTGGGTTTTTTTTAGCACC TGGAAAGTTTTTTTGTACTATATGCAACTCCTACTTCACATTGCCTGTGACCATTCAGAATAGAAAAAGGTCTGTTGATGCATGCCAGTG CTGGTTACTAGTCAGTGACAGAGAACACAGAGAGGGACAAACACAGCCATGAACCCCCTGGCACTAGTACCAGCACCTAGTTGGCAAGTA GTGGGTGCATCTCTCAAGTGAAGTGTAGATTTGTATTTAGTCCTGCTTGCTCTCATAAAAAGAGCCAGTTCTTTTCTCTGCTGAAAGATG TCTTGAGAGTATTACAGGTAGACTTGGTTTTTAGAATTCATAAAACTGACAGGCAGGGGAATCTTCCTGAGTGACAGCTTGGTTTAAATT TAGCACAGAACTAGATGAGTTGCACTTTTCTAATAACATAGGATGGATTTGGGGAAGGGAACATTTTCCCTCATCCTCTGAAAGTGGAAA CCAGACTGAGATGGTAAGTTAACTGATAAAACCTGTCAGCATTCCATCATTTTCCCCTTTTGACGTATCAGTACTTCTAAGAAGGGATCT AAGCACAATTAAGTGAATTGAGTCCCTGGTCTAGCCTCAGGAACTGAAACTTCTTTGGGGCTTGTCTTGAGACGTGGCAAATTCTCCTTG GTGAGTTTTCTAAAAGTATTTCCCCATGGAAAGGAGAAAGTGGTTTGGGACAGAAAGAAATGGAATGTCTTCAGTCATGGAAGAGCCTCC ATTTCATCTCATGTCCATTTCTAGCCTCTTTCAAAAAGCACAGTGCATCATGAGCAACAGAAAAGCAGTAGAATCCTAAAGGACATAACA GTTGTTCCGTAACTAGAAGCATTCTTTGATTTTAAATTTGAAGCTGTTCAGTTTGCAGCTGGGGATATGTGCATGGTTGGGAACTTATAC ACATAGAGCCATTAACTACTTAAGCAGCTGCAGTAGACCTGATTTTCTGTTTGCAGTATAGAGATTGATTTCAAGGGAGTTACATTATTT GAAAAGTTATGACTTTCAGCCTTTGAGGTTTTAAGAATCCCTTTTCATGGTCTGATCTTAAGTTGTTTGAAAAAAGATTCACGCTTCTGC ATCCACCTCTGCCCTCATTCTGTCAATTGTGTGTGGACTCTGAGAAGCCTGCTTGATAACTTGTCTTAAGTTCTATTAAGGCAGTTAGAC TGAGATTTCTAATGACTTCACCATAAAGATTATACTTCTGCCTGGCGTCGTTTCTATAAAACACTATAGGACATTTGTTTTCAAAAGCAG TTGAGTAACAGCAACATAAACCACATTTTTTAAAAAAATGAGCACTTTTCATTCACTTGAAAGCTTAAGTGGGAAAAAGGAAGATGATTG TCAGGGGAAAAACTTACAAAATGCTACAGTGTTTACAAATGCCAGTTCCAGGTGATTAGAAAGGCCGTTTTCATTATGGTTCAGATTTGG AATAGCTTATGCAAAGATTGTGTTCATTTTTATACAATTCTTTTTAACTTTAAATTGCCATCTGTGTTTTAAACATAATTCTGCACTTTG GAATCAGTTCATTAGAATGATAACATTTATATGGATAAAGATGCAGTATTCCTTATTCTGTACTTGATTTATTATACTTACCAAAGCTGC AACTGAATAAATCTGGTGAGGTGAGGCCTTCAAAATGTATTAATACGCCTTTGTTATGTTGTTATGACTGCTTAGAAATGTAGCCATGAT GTTGTTCTAAAGATGTCTTAACATTTATAGTGAGGATTGACAGAAATTAAGCAGTGTTAAGAATACCAGCATCCATGTTACAGTCTGCGT ATAAGGGACTGAATGTGAGGTAACTCTTATGAATCATAATAGGCCCAGAAAGCCTTAATATTCATAGTTCATAATCCAGTCTCAGATTTT GCTCTTCAATGTTGCCTGTAAACTTAGCAGGTAAATGTATTCTAGTATAAAACATCATTGACCAAATCTCTTCCTTTAGTTTTTCTGAGG TAGTGCATCCCATTAAAAAAGTCTCTTCAATTAGATTTGGCTTTAGTTTAGAAAGGGGTTTGGTAAGTCATGTCTTCCATATGACATTTC TACTCATCCCCACACTGCCTTCCACTTAACCTGTACAGACAGCCCCAACACATGCACATGTGTGTACACAACTGTATATGCAGCAGCCAG TGGGCTAACAAATATCAGCAAAGAACTTTTTTAAAAAGAATTTGTAATAATCCGTGCTGTCTAGAAATGTGAGTTACTTACCTTATTAGG AAACCGGCTTATAATACTATATATGACTCTGCCTGCATTTTATAGTTAAGAAATGTACATAAAAATTGCTATATTTTCACAGTTTCATTA TAATGTCTGTTTAGTAACCCATGTCCACTGATACTTTAAATATGCTAATTACTGAGCAATTGCAATAGAAATCCAGATTTTCATAAGAAA ATGAAATAGAAGGATACTGCATCTTTAAAAAATAGAGTGAAGATATTTTACTGTATTCGTAACATATGTGATAGTGGAAAAAGTATTTTC AAACTCACAAATTTTACAGAGGTTGTAAATAGTTTGATGAAGTATGTTGGGAAAGAGAGCTTCTAGTTTTCATCACAATAAAAAGAAAAA ACTTGTTCAGATATGCCTTGTATATCTTACACACAATGAGTGAAATTGCCATGGGAACTCTGTCCAACTTTGTCAGAGCATGCTCTTCGT GTTCTGTTCAAAATAGAGTGGCCACTTGTCATGGTTTAGCCAGGATGGTTTAAAATATAATGAAGTCATTTTAAGTTGCAGACAACTGAT TCCAAACTAGTAATGTCTTTTCCTGAAAAGGGCAAAACAGCTGCACAGGATTTTGCTTGTACTAAAGAGGAGCATCTTACAATTGTTCTC TTTTCTCAGTTATCTCCCTCCTCAACAGAGTGTGAACAACCATACAGGTGTTTATTCTTGTTTTATTCCAGGGAGACTGCTTTTAGGTAT AACTACATGTTGACAAGATTAAGTGCTGTGGATATGGCCACGTGTTAAAGGAATCTATACTCGCAATAGGAATAAGCTAATGCCCATTTT CAGAAATAAATTAAATGCTGAAAGTGCCTGTCAGTAAACCTTATGACCAATGAGATATTCCTATACTTTTACACAGCAATAATTCTTAAT AAGACTGGGTTTTTTCCTGCACATGTGAACACACACACACATACACACAGAGAGAGTAAATACATACACATAGTAAATCAAATCTGTTCA CATGCCCACAAAAAACGCTTTTATAGCTTTCAAATATACCTAATCTTGTTTACATTAACATTTCTTAATTTGATCTTTCTAACTTGCAGA ACGTTAAGAACACAAATCTGAACATTAAGTTTATCTTCAGTGAACACTATTGCATATGGTAATTATAATTTCCAGATAAAAAGTTGACTG TCATTTGCCCCAAACTTATGAAACAGTATGTATGATTCAAAAAGTTTTGCTCAGTTAAAAACACCAATTTATTTGGCGCAAAAGACTGAA GGATATTTGTTTGCTTGTTCATTTTATCCACTCATATCAAACGCACAAATTCATCTTTACATTTCTTCATTCCCCTTTCCCCTAATATTT CCTATTATCATCTTAAGAATCATTTTGGAATGAATATTGACAGAATCATTTCTCCCCAAAAAGTCTGTTGAAGTACCACTGACACTTAGT AAGCCTAGCCTTTAACCATCTTTGCAGTTAGTCCTAAAAATTACCAGATGCACATTCAGAAGCTCACAGGTTTTTTCCTGTAATTACTGT ACTGCTAAAAGTGGAGTCATGGATAGAAATATACAATGAGACTATATGAATAGACATGAACCCTGGAAATTCTCCAACCCTGCCATCTCA GAGCACAAATTCACCCAAACAAGCTACTGAGGCTATCAGTAAAATTATACTCATGGAGAGTCACACATCGGGTAAGGGCAATTTTAAAAG TAGGACTGTGATTAAACATTCAGGCTTTAGACTTCCATGATGGACTCAGACCACAGGCCTCAAAAAAACATCCACTGTTTTCTCCTCCCA ATGTTAGAAAGAAGAAAAGGGAGACGGAAATGTACCAGGATAAGGGGGTAAAATAACCAATTAAGTGTCAAAGGAAAGCTGCTGGGTTCC TTAATCTCACTGAAGTCAAGTCTTCTGACTGGGCTTCTTACCATGTGTTGTCTGAAAAAACTAAAGTACCTTGAAAGGTTACACATTCAG CAAACCATGAAGATAATAGCTATTCTTTATTAAACACTGTGTGCCAAGCAATAGACTAGGCAATTTTTAGATACGTTACCTGCAACCTGT ACAACATTTCTACACTTTATGGATGGGAAACGGAGACATGGGAAGTGTGGCTGAGTTGTTCATGGATGTAGAAATAGTAAACGGCAGAGT AGGAAAGTGAAACCGCCTATCTCTGACCTGGAGGTCTGCCTGTATCTTTCCCACTCCACCACACTGCACGTGGGTGTCCCGAAACCACCT TCCCAGATTCCTGACTCTCAGTAATTTTATTATGGACAACATGCATGAGTAGTCATCATATTTTTCAAGTGAAATATCGGGACATGATAT AACACATGACTTAACAATGGTACTGAATATTTGAAATCAGGCCTTTCCCGGAAAATCATGCATGAAGGATCATTATAAACAAACAATAGC AACCAGTTGTCTCCCCGAACTTGTCACTTTTCTCATAAATGTCTGGCCTGGAGCTCCAAAATCATCCAAATACTTAGTAGCATTTTAGCC TGAGTACACTTTCTCAGTTCCTCAACTCTTTGTATACCTTTCCACCAATATAGACATTCTAGAATCTGCTTCAGATGCATTTGAAATTTT CACCCCCATGGAACTAGTGATTAATATCAGAGCCCACTCTTGCAGTTGGTAATGGGGTGGCAATCAAACGTTCAGATGATGATAAAGGAG AGATAATGGATAATTCTTTTTCAGAGTTCTCACTTAACAGCTCTGTTGTGGAATGTTTTAAATAGTCTTATAAATAATTTGTTTATAGTA TTGTTGTTAGTTTAATTGAATTTTATGTAAGAAGCTGTCCAACATCAGAGAAATGAAATTCCTCCCACTTTCTGTGTAGAACAAGGTCTC TGACAGTATTGATTCATGGAAGTACTAATGGACTTAGAAAACATTAAGAGAATGTCATTTCTCATAGTGTTTCTGTTTCTGAAAATGAAT CTCCTGAATTATTATCTTTCTCCCTGTTACTTGGCTGGGGAAAGAGATAGAAGCTGTATAAACAAATTCTCTTCCATGCTCAAAGCAAGT GTTCCATGTGCACAACCTGCTGCAGACTGGGGCCCTTCTCAGTTAATTGGGTTTCACAAGCAATAATTTCTCCACAACAAAAACCACAAC TTGAAGTGAGTTGAAAAGAGATCAATAGTGGAAACAGTCGCCTCAGTACTTTTTCTTTCTGGATTTCATCTCTAGAAATTTGAAGTGTTT GAGACAGAGTCCACCCTTTGTGCAAGGCGAGAACCAATGAATGGACTCCTTGTGTGAATTATTGCATCTTCTTCCAAAGCAGGTTCATCA AGACTTTCACAGAGATTCATTTTTGTTGAGAAGTAAGGGTTAATAGGAGGATAGAATTTGGATCCAAATCTAGTGATAAAAGTGTCCAAG CAATCAAAAAGTAAGATATTTTAGGGACATACCAACATCTTCCCTTTCTGCTAATTTCATGCTCCAAAGATATGGCAAAAAAAAAAATCA TAAAAAGTGCTTTTGCCCTACTTGTGTTCTAGTTTTCCCATGGCAGAATTTTGTAATTACATCCAGAATATAGTGTATATTTTGTTCCTC AAACTTTATTACATTGGATGGATATTGTTGAACTGGGGCACTGGTGCCTATATTCAAGGCTCTTTCCTATCAACGTGTCTGTCCACGATT TGTTGTGTTTAAAGCTTCATTTTGAAAAATCACTGTCCCCCTGTGGGGTAGTGACTGTATTGTTTTGTTCATGTCTATGTGGGACACATT GCATCACATGGCAAACCAACTCTCTGTGGATGTGAGATAAGTACTTATAAAACCAGCTTGAAAACATCGTCTTATGTATTATGTCATCCT GCATCATAATGCAATTATGTGTATCATAACATGCTCATTTAAAAAAAGAGAAACCAGCAAATTCATGTTTGTCCATAGAAGAATGTACTC AGAACTTTGTGTTGTGAAACGATGAGAACAGACCACCTTTAAGATACCCACCTGCCACTTAAAATGACTTAGTTATAATTAGTAGTAGTC TAGACGTTGTTCTTGGTGTGTGGGGGTCAATTCTAACGTCATGTTCTTTTGAATAAATCTCTCAGTCATATTTGAAAAAAAAATACATGG GAATAAAGAAAAATATCATCTTTGGCCAAATCAAGCAGGCATCTTTTTTCTTTTCCTTGACGTTTAGCTCATTATACGTGGTGATTGGAT CACGAGATCTGTCCGTGTGAAAATACAGAAACATCCTTTAGTTTACAAAACAGTTATTCTAGGCTTGAAGCCTCTGAACAGCAAATTGAA TAGATGGGCTGCATCTGATTTGCTTTATGGATGTAATTTTACAAAACACTCTTGGGTCTCTGACCCCAGGGAGTTAAGAGTGCCCAGAGG AGGTCCTACACATTAAAGGATAAAGCCCCCCAGTGATGCTGGCAAGCAAATGTGTTGAGTTCTTAAATCTTCATTTGGTTTTCTGTTCAG GATTTTAATTGCAAATGAATTTATTTCTCCAGTTTATCTAAAGACCTAATTTCCCAATAGTTTCCTCTGCATTTATATACTCTGTAGTGT TTAGGCAACCCTGTTATAAGTTTATTAATATTATGTAAGTGTTGTTCTTGTATTTATGTATAGTGTATGTATTGTAAATATACTCAGAGC TTTTTTCCTTTTACTGTAAAATGGTGATTTTTTTGCCCTATGATAATGTAAAGGGAGACCCTCCTAATGAGATTCTCTCAGAGGATGATT ATTCCAGTCTATTCTCAGAGATTTAAATGAACAAGTGTTATTGTTTTTAATGGTGTCTCAGACATATTCTGTTGGTGCATTGCTTTTCTG TATTCAACTTTCCTATGAATTGAGCTGTGAACTGAAATAGAGTTTAAACCTTTAACTGTATGCATTTGTATAATTATCTGAATGAAGGCA TGAAGGTTAAATAAAGCATTTTGTATGGAACAAAA >22898_22898_4_DIS3-KLF12_DIS3_chr13_73345932_ENST00000377780_KLF12_chr13_74420510_ENST00000377669_length(amino acids)=866AA_BP=505 MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIVSAWRPGTWASVA SSLRLPGSLETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDR LACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKS QWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQA STLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDP PGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKSPNVHNYPDMEAVPLLLNNVKGEPPEDSLSVDHFQ TQTEPVDLSINKARTSPTAVSSSPVSMTASASSPSSTSTSSSSSSRLASSPTVITSVSSASSSSTVLTPGPLVASASGVGGQQFLHIIHP VPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQMDPRGLSPRQSKSDSDDDDLPNVTLDSVNET GSTALSIARAVQEVHPSPVSRVRGNRMNNQKFPCSISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKP YKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV -------------------------------------------------------------- >22898_22898_5_DIS3-KLF12_DIS3_chr13_73345933_ENST00000377767_KLF12_chr13_74420510_ENST00000377666_length(transcript)=2883nt_BP=1706nt GGAATGGAAAGGGAAGAACCTCCGGGGTTAGGCGTATTCTAGATTGACGCCTTTTGCTGGAAGAGCGCTGCTGGGGTTAGGATTCTGCGC GGCGAGGCAAGATGCTCAAGTCCAAGACGTTCTTAAAAAAGACCCGGGCGGGCGGCGTGATGAAGATCGTGCGCGAGCACTACCTGCGAG ACGACATCGGCTGCGGTGCGCCCGGGTGCGCAGCGTGTGGAGGGGCGCACGAGGGGCCGGCCCTGGAGCCGCAGCCCCAGGACCCGGCGA GCAGCGTCTGCCCGCAACCGCACTACTTGCTGCCCGACACTAATGTGTTACTGCACCAGATTGATGTTCTTGAGGACCCTGCCATCAGGA ATGTAATTGTGCTACAAACAGTTCTTCAAGAAGTGAGAAATCGCAGTGCCCCCGTATATAAACGCATCCGAGATGTGACTAATAACCAAG AGAAGCATTTCTATACTTTCACTAATGAGCACCATAGAGAAACCTATGTAGAACAAGAACAGGGAGAAAATGCTAATGACAGGAATGATA GAGCGATTCGAGTAGCAGCAAAATGGTACAATGAACATTTGAAAAAAATGTCAGCAGACAACCAGCTGCAAGTTATCTTCATAACAAATG ACAGGAGAAACAAAGAGAAAGCCATAGAAGAAGGAATACCAGCTTTCACTTGTGAAGAATATGTAAAGAGCCTAACTGCTAACCCCGAAC TCATAGATCGTCTTGCTTGTTTGTCTGAAGAAGGGAATGAAATAGAAAGTGGAAAAATAATATTTTCAGAGCATCTTCCCTTAAGTAAGC TACAGCAAGGCATAAAATCTGGTACATACCTTCAAGGAACATTTAGAGCTAGCAGGGAAAATTACTTGGAAGCTACAGTATGGATTCATG GCGACAATGAAGAAAATAAAGAGATAATCTTACAGGGACTTAAACATTTAAACAGAGCTGTTCACGAAGATATTGTGGCTGTGGAGCTTC TCCCCAAGAGTCAGTGGGTAGCACCATCTTCTGTGGTTTTACATGATGAAGGTCAAAATGAAGAAGATGTGGAGAAAGAAGAAGAGACAG AACGAATGCTTAAGACTGCTGTAAGCGAGAAAATGTTGAAGCCTACAGGTAGAGTTGTAGGAATAATAAAAAGGAATTGGAGACCATATT GTGGCATGCTTTCCAAGTCTGACATTAAGGAGTCAAGAAGACATCTCTTTACACCTGCTGATAAGAGAATCCCTCGAATTCGCATAGAAA CCAGACAGGCTTCCACATTAGAAGGACGGAGAATTATTGTTGCTATTGATGGTTGGCCCAGAAATTCCAGATATCCAAATGGACACTTTG TGAGAAATTTAGGTGATGTTGGAGAGAAAGAGACTGAAACAGAAGTTTTGTTACTTGAACACGATGTTCCCCATCAGCCTTTTTCACAGG CTGTTCTTAGTTTTCTGCCAAAGATGCCCTGGAGCATTACTGAAAAGGACATGAAAAACCGAGAAGACCTGAGGCATCTGTGTATTTGTA GTGTAGACCCACCAGGATGTACTGATATAGACGATGCTCTACATTGTCGAGAACTCGAAAATGGAAATTTGGAGGTTGGTGTTCATATTG CTGATGTGAGCCATTTTATTAGGCCAGGAAATGCCTTGGATCAAGAATCAGCCAGAAGAGGAACAACTGTGTATCTTTGTGAAAAGTCTC CAAACGTCCACAACTATCCCGATATGGAAGCCGTTCCCCTGTTGCTAAATAATGTGAAAGGGGAGCCCCCGGAGGACTCGTTATCTGTAG ATCACTTCCAAACACAAACTGAGCCAGTGGACTTGTCAATAAACAAAGCCAGGACGTCCCCTACTGCCGTTTCATCCTCCCCAGTTTCCA TGACAGCATCTGCCTCCTCACCTTCTTCAACTTCAACCTCTTCATCGTCTTCTAGTCGTCTAGCCTCATCCCCAACTGTTATCACATCAG TATCTTCAGCGTCATCTTCGTCAACAGTATTAACTCCAGGGCCCCTTGTGGCCTCTGCATCTGGTGTTGGAGGCCAGCAGTTTTTGCACA TTATCCATCCCGTACCGCCTTCAAGTCCCATGAATTTACAGTCTAACAAACTGAGTCATGTTCACCGCATCCCCGTGGTGGTACAGTCGG TGCCTGTTGTCTACACAGCTGTAAGGTCACCTGGAAATGTGAACAACACTATTGTCGTGCCGCTTTTGGAGGATGGGAGAGGCCATGGCA AAGCACAAATGGACCCCCGAGGCCTATCTCCCAGACAAAGTAAAAGTGACAGTGATGATGATGACCTGCCAAATGTGACCTTAGATAGCG TTAATGAAACTGGATCTACGGCCCTTTCCATAGCCAGAGCAGTACAAGAGGTACATCCGTCCCCAGTATCAAGGGTCCGGGGCAATCGAA TGAATAATCAAAAGTTTCCTTGTTCAATTTCACCATTTAGTATTGAGAGCACAAGACGCCAGAGACGGTCTGAATCCCCAGACTCCAGAA AACGGCGTATCCACAGATGTGATTTTGAGGGATGCAACAAAGTGTACACAAAAAGTTCTCACCTGAAGGCTCACCGGAGGACACATACAG GAGAGAAACCTTACAAGTGTACCTGGGAAGGCTGCACCTGGAAGTTCGCTCGTTCAGATGAACTGACGAGGCATTACCGCAAACATACGG GAGTGAAGCCATTCAAGTGCGCGGACTGTGATCGCAGCTTTTCCCGGTCAGATCATTTGGCCCTGCACCGCCGGAGGCATATGTTGGTGT GAGGAATGCTACCTGTCCAGCTGAGCGTAAGAGCTGGATCTCTTAGCGGCACCCAATTCAGCAGGGCTGAATCCCCTTCACAGTGTTAAC ACA >22898_22898_5_DIS3-KLF12_DIS3_chr13_73345933_ENST00000377767_KLF12_chr13_74420510_ENST00000377666_length(amino acids)=896AA_BP=535 MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIV LQTVLQEVRNRSAPVYKRIRDVTNNQEKHFYTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRN KEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNE ENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGML SKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLS FLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKSPNVH NYPDMEAVPLLLNNVKGEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPVSMTASASSPSSTSTSSSSSSRLASSPTVITSVSSA SSSSTVLTPGPLVASASGVGGQQFLHIIHPVPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQM DPRGLSPRQSKSDSDDDDLPNVTLDSVNETGSTALSIARAVQEVHPSPVSRVRGNRMNNQKFPCSISPFSIESTRRQRRSESPDSRKRRI HRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV -------------------------------------------------------------- >22898_22898_6_DIS3-KLF12_DIS3_chr13_73345933_ENST00000377767_KLF12_chr13_74420510_ENST00000377669_length(transcript)=12193nt_BP=1706nt GGAATGGAAAGGGAAGAACCTCCGGGGTTAGGCGTATTCTAGATTGACGCCTTTTGCTGGAAGAGCGCTGCTGGGGTTAGGATTCTGCGC GGCGAGGCAAGATGCTCAAGTCCAAGACGTTCTTAAAAAAGACCCGGGCGGGCGGCGTGATGAAGATCGTGCGCGAGCACTACCTGCGAG ACGACATCGGCTGCGGTGCGCCCGGGTGCGCAGCGTGTGGAGGGGCGCACGAGGGGCCGGCCCTGGAGCCGCAGCCCCAGGACCCGGCGA GCAGCGTCTGCCCGCAACCGCACTACTTGCTGCCCGACACTAATGTGTTACTGCACCAGATTGATGTTCTTGAGGACCCTGCCATCAGGA ATGTAATTGTGCTACAAACAGTTCTTCAAGAAGTGAGAAATCGCAGTGCCCCCGTATATAAACGCATCCGAGATGTGACTAATAACCAAG AGAAGCATTTCTATACTTTCACTAATGAGCACCATAGAGAAACCTATGTAGAACAAGAACAGGGAGAAAATGCTAATGACAGGAATGATA GAGCGATTCGAGTAGCAGCAAAATGGTACAATGAACATTTGAAAAAAATGTCAGCAGACAACCAGCTGCAAGTTATCTTCATAACAAATG ACAGGAGAAACAAAGAGAAAGCCATAGAAGAAGGAATACCAGCTTTCACTTGTGAAGAATATGTAAAGAGCCTAACTGCTAACCCCGAAC TCATAGATCGTCTTGCTTGTTTGTCTGAAGAAGGGAATGAAATAGAAAGTGGAAAAATAATATTTTCAGAGCATCTTCCCTTAAGTAAGC TACAGCAAGGCATAAAATCTGGTACATACCTTCAAGGAACATTTAGAGCTAGCAGGGAAAATTACTTGGAAGCTACAGTATGGATTCATG GCGACAATGAAGAAAATAAAGAGATAATCTTACAGGGACTTAAACATTTAAACAGAGCTGTTCACGAAGATATTGTGGCTGTGGAGCTTC TCCCCAAGAGTCAGTGGGTAGCACCATCTTCTGTGGTTTTACATGATGAAGGTCAAAATGAAGAAGATGTGGAGAAAGAAGAAGAGACAG AACGAATGCTTAAGACTGCTGTAAGCGAGAAAATGTTGAAGCCTACAGGTAGAGTTGTAGGAATAATAAAAAGGAATTGGAGACCATATT GTGGCATGCTTTCCAAGTCTGACATTAAGGAGTCAAGAAGACATCTCTTTACACCTGCTGATAAGAGAATCCCTCGAATTCGCATAGAAA CCAGACAGGCTTCCACATTAGAAGGACGGAGAATTATTGTTGCTATTGATGGTTGGCCCAGAAATTCCAGATATCCAAATGGACACTTTG TGAGAAATTTAGGTGATGTTGGAGAGAAAGAGACTGAAACAGAAGTTTTGTTACTTGAACACGATGTTCCCCATCAGCCTTTTTCACAGG CTGTTCTTAGTTTTCTGCCAAAGATGCCCTGGAGCATTACTGAAAAGGACATGAAAAACCGAGAAGACCTGAGGCATCTGTGTATTTGTA GTGTAGACCCACCAGGATGTACTGATATAGACGATGCTCTACATTGTCGAGAACTCGAAAATGGAAATTTGGAGGTTGGTGTTCATATTG CTGATGTGAGCCATTTTATTAGGCCAGGAAATGCCTTGGATCAAGAATCAGCCAGAAGAGGAACAACTGTGTATCTTTGTGAAAAGTCTC CAAACGTCCACAACTATCCCGATATGGAAGCCGTTCCCCTGTTGCTAAATAATGTGAAAGGGGAGCCCCCGGAGGACTCGTTATCTGTAG ATCACTTCCAAACACAAACTGAGCCAGTGGACTTGTCAATAAACAAAGCCAGGACGTCCCCTACTGCCGTTTCATCCTCCCCAGTTTCCA TGACAGCATCTGCCTCCTCACCTTCTTCAACTTCAACCTCTTCATCGTCTTCTAGTCGTCTAGCCTCATCCCCAACTGTTATCACATCAG TATCTTCAGCGTCATCTTCGTCAACAGTATTAACTCCAGGGCCCCTTGTGGCCTCTGCATCTGGTGTTGGAGGCCAGCAGTTTTTGCACA TTATCCATCCCGTACCGCCTTCAAGTCCCATGAATTTACAGTCTAACAAACTGAGTCATGTTCACCGCATCCCCGTGGTGGTACAGTCGG TGCCTGTTGTCTACACAGCTGTAAGGTCACCTGGAAATGTGAACAACACTATTGTCGTGCCGCTTTTGGAGGATGGGAGAGGCCATGGCA AAGCACAAATGGACCCCCGAGGCCTATCTCCCAGACAAAGTAAAAGTGACAGTGATGATGATGACCTGCCAAATGTGACCTTAGATAGCG TTAATGAAACTGGATCTACGGCCCTTTCCATAGCCAGAGCAGTACAAGAGGTACATCCGTCCCCAGTATCAAGGGTCCGGGGCAATCGAA TGAATAATCAAAAGTTTCCTTGTTCAATTTCACCATTTAGTATTGAGAGCACAAGACGCCAGAGACGGTCTGAATCCCCAGACTCCAGAA AACGGCGTATCCACAGATGTGATTTTGAGGGATGCAACAAAGTGTACACAAAAAGTTCTCACCTGAAGGCTCACCGGAGGACACATACAG GAGAGAAACCTTACAAGTGTACCTGGGAAGGCTGCACCTGGAAGTTCGCTCGTTCAGATGAACTGACGAGGCATTACCGCAAACATACGG GAGTGAAGCCATTCAAGTGCGCGGACTGTGATCGCAGCTTTTCCCGGTCAGATCATTTGGCCCTGCACCGCCGGAGGCATATGTTGGTGT GAGGAATGCTACCTGTCCAGCTGAGCGTAAGAGCTGGATCTCTTAGCGGCACCCAATTCAGCAGGGCTGAATCCCCTTCACAGTGTTAAC ACAAAAGGGCATCACCATCCCACGATGTCTGAAACCAGAGCAGGAAAAAGAAGGCACACTTCTTTTGGTCTGAAGGTAACCCCCATCATG ACTAGACGAGAACCGTCTTTACCCGGGCCTGGGAGCTCAGTGACATAAATGCTGAAGAGACAGGCATTGTTTTCCGTGCTGTGTCCTCTG CCATTTAAAGATGTTTGTAGCTTGTACATTTTCTGAGCTGTCAGACATTTTGTTATTGATACCTTAAAGGTCACCTACCACAAATTGATG GCTAGAGCAAGACCTTTTAAATTTGGATGAATCTCCCATCATCCCATCCCTTAACCCCTTTTTACAGAAATTTTAGTTACAATCTGAGTA AGCTAGAACACACATCCAATCTGTTACCAGCAAGCAGCATGAAAGTAGAAACGAAGAAGCAGATGGAGAGGTCCCATTACCTGCAAAGAA AGGGCACTCAGGCAGCCCTTTGCAATCGCGATGGCAGCCACTAGATATCACTCTCAACTTGTCATTCTGCCATGCCCTGAAGAAAACCAA CATTGAATCTTTCATTTGTTTGTCGTTGATTGTTTTTGTTTTGTTTCGATTCTGTTTTGTTCATCTGTTCGAGCAGAGGGGCAGTTGAAG TCTCGTCCTGGTCTCTGCCCTGGCATGGACTGGCACAGAGGTGTTCTGTAGTTGAATAGGAAGAGCCTGTCTAAAAAACTACTGCCCCAC TTCAAATTGCAGTGTTCTGTCACCTAGGCATCATCTCTTCCTGCCCCTAGTATTTGATTACAAGGAACCAGGGGAAAAAAACTTTCTTAG ACACACTGGCACCAAGGTAAGAGGTGGGGCTGCCCAGGCAAAGTCAGTGAACATGAAAACTCAGACAAAGCAGAGATGGAAATAATGCGC CTCTTGAGGAGAAAAGCAATAATGAATAAAAGGACTTTCCTACAATAACTTCACTGAGGACTCACGTTACCAATTTTCATACTTACTAAA GGGATTGTAAAAAACACCCCAGCATTTTAGGTGTCTTGGTTCCATTTACAGCACTGAGGTAATCTTTCTGCTGTTTGTTGTCCTGCTTGG TTGAGTACCACAATTAAAGATTATGCTCCCCTTTTCTTGTTTGAAAACAGTTATTTGGTGACTAGAAAGGCAAGGGAGGCATAGCCGGGA ATTAACTCTTCGGTTAATGGGTCAGTTCTCCTTGGAACTGAATCAGTGGAAAGAGAATGCTTCCCATAGAAAGCCCGACATGGTGCTAGT TTCCTCTCTTGGAGAGCCAAGGATAAGTGACTCTCCAATAGGTTCTTCTATACCGATTTCATTTTCTAAACTGTATCAGGACCCAGGTGT CCTGCATTGGCATCTGCAGGGATATTGAACCCACTCATCCTGTGCAGAGGATGAGAGGAAGGTGTTAGTTCCATCAGCCCCATAAAATTA TGAACCTTTTTGCAACTAGGAACATATACAGTAAACAAGCAATACATCACCAACGAGCATTCTTTCAGAAAAATTACCATATTTTTGTCC CCACCACAAGCTGGGTTTTTTTCCAGCTTTCTGTGGCTGAGGGGCTGGTGAGATTTTTTGTTGTTATTGTTGTTGTTGCTAGAATTTTTT ATAGCTTAGATATAAAAGGTCTCCAACAAAGACCTTTGCAATATATTTTAATTACAAACACTTGATTTTGGGAATTGCACATATTAACCT CACAATATTACTAGCTCATTTTTAAATGTCTGGACATTCTGAAATAATTTCCGGTTACAGAATTACCCTTTTTAGGATCATCTTCTAATT CAGATAATCTTATTCTGATGAAGCGAGAACTATGAACGTTGAAACAAGGACAATTTGTGTTGGATGGTATTCAAAAGGAATTTTTTAAAA CATTAAGCAACAGTGTAATGATTTTCAGGTCAAATTATGGCTTCACAAATATGTGCTCTATATTGTCTGCCAGGTCTCAAAAATTCATCA AGCAATTTCCCTCCAACAAGGGCTGCAGTTCTAGTGATAAATAGCATCTTTAGCTGCACAGTCTACTACTCATCAACCAGTGGGTTTTTT TTAGCACCTGGAAAGTTTTTTTGTACTATATGCAACTCCTACTTCACATTGCCTGTGACCATTCAGAATAGAAAAAGGTCTGTTGATGCA TGCCAGTGCTGGTTACTAGTCAGTGACAGAGAACACAGAGAGGGACAAACACAGCCATGAACCCCCTGGCACTAGTACCAGCACCTAGTT GGCAAGTAGTGGGTGCATCTCTCAAGTGAAGTGTAGATTTGTATTTAGTCCTGCTTGCTCTCATAAAAAGAGCCAGTTCTTTTCTCTGCT GAAAGATGTCTTGAGAGTATTACAGGTAGACTTGGTTTTTAGAATTCATAAAACTGACAGGCAGGGGAATCTTCCTGAGTGACAGCTTGG TTTAAATTTAGCACAGAACTAGATGAGTTGCACTTTTCTAATAACATAGGATGGATTTGGGGAAGGGAACATTTTCCCTCATCCTCTGAA AGTGGAAACCAGACTGAGATGGTAAGTTAACTGATAAAACCTGTCAGCATTCCATCATTTTCCCCTTTTGACGTATCAGTACTTCTAAGA AGGGATCTAAGCACAATTAAGTGAATTGAGTCCCTGGTCTAGCCTCAGGAACTGAAACTTCTTTGGGGCTTGTCTTGAGACGTGGCAAAT TCTCCTTGGTGAGTTTTCTAAAAGTATTTCCCCATGGAAAGGAGAAAGTGGTTTGGGACAGAAAGAAATGGAATGTCTTCAGTCATGGAA GAGCCTCCATTTCATCTCATGTCCATTTCTAGCCTCTTTCAAAAAGCACAGTGCATCATGAGCAACAGAAAAGCAGTAGAATCCTAAAGG ACATAACAGTTGTTCCGTAACTAGAAGCATTCTTTGATTTTAAATTTGAAGCTGTTCAGTTTGCAGCTGGGGATATGTGCATGGTTGGGA ACTTATACACATAGAGCCATTAACTACTTAAGCAGCTGCAGTAGACCTGATTTTCTGTTTGCAGTATAGAGATTGATTTCAAGGGAGTTA CATTATTTGAAAAGTTATGACTTTCAGCCTTTGAGGTTTTAAGAATCCCTTTTCATGGTCTGATCTTAAGTTGTTTGAAAAAAGATTCAC GCTTCTGCATCCACCTCTGCCCTCATTCTGTCAATTGTGTGTGGACTCTGAGAAGCCTGCTTGATAACTTGTCTTAAGTTCTATTAAGGC AGTTAGACTGAGATTTCTAATGACTTCACCATAAAGATTATACTTCTGCCTGGCGTCGTTTCTATAAAACACTATAGGACATTTGTTTTC AAAAGCAGTTGAGTAACAGCAACATAAACCACATTTTTTAAAAAAATGAGCACTTTTCATTCACTTGAAAGCTTAAGTGGGAAAAAGGAA GATGATTGTCAGGGGAAAAACTTACAAAATGCTACAGTGTTTACAAATGCCAGTTCCAGGTGATTAGAAAGGCCGTTTTCATTATGGTTC AGATTTGGAATAGCTTATGCAAAGATTGTGTTCATTTTTATACAATTCTTTTTAACTTTAAATTGCCATCTGTGTTTTAAACATAATTCT GCACTTTGGAATCAGTTCATTAGAATGATAACATTTATATGGATAAAGATGCAGTATTCCTTATTCTGTACTTGATTTATTATACTTACC AAAGCTGCAACTGAATAAATCTGGTGAGGTGAGGCCTTCAAAATGTATTAATACGCCTTTGTTATGTTGTTATGACTGCTTAGAAATGTA GCCATGATGTTGTTCTAAAGATGTCTTAACATTTATAGTGAGGATTGACAGAAATTAAGCAGTGTTAAGAATACCAGCATCCATGTTACA GTCTGCGTATAAGGGACTGAATGTGAGGTAACTCTTATGAATCATAATAGGCCCAGAAAGCCTTAATATTCATAGTTCATAATCCAGTCT CAGATTTTGCTCTTCAATGTTGCCTGTAAACTTAGCAGGTAAATGTATTCTAGTATAAAACATCATTGACCAAATCTCTTCCTTTAGTTT TTCTGAGGTAGTGCATCCCATTAAAAAAGTCTCTTCAATTAGATTTGGCTTTAGTTTAGAAAGGGGTTTGGTAAGTCATGTCTTCCATAT GACATTTCTACTCATCCCCACACTGCCTTCCACTTAACCTGTACAGACAGCCCCAACACATGCACATGTGTGTACACAACTGTATATGCA GCAGCCAGTGGGCTAACAAATATCAGCAAAGAACTTTTTTAAAAAGAATTTGTAATAATCCGTGCTGTCTAGAAATGTGAGTTACTTACC TTATTAGGAAACCGGCTTATAATACTATATATGACTCTGCCTGCATTTTATAGTTAAGAAATGTACATAAAAATTGCTATATTTTCACAG TTTCATTATAATGTCTGTTTAGTAACCCATGTCCACTGATACTTTAAATATGCTAATTACTGAGCAATTGCAATAGAAATCCAGATTTTC ATAAGAAAATGAAATAGAAGGATACTGCATCTTTAAAAAATAGAGTGAAGATATTTTACTGTATTCGTAACATATGTGATAGTGGAAAAA GTATTTTCAAACTCACAAATTTTACAGAGGTTGTAAATAGTTTGATGAAGTATGTTGGGAAAGAGAGCTTCTAGTTTTCATCACAATAAA AAGAAAAAACTTGTTCAGATATGCCTTGTATATCTTACACACAATGAGTGAAATTGCCATGGGAACTCTGTCCAACTTTGTCAGAGCATG CTCTTCGTGTTCTGTTCAAAATAGAGTGGCCACTTGTCATGGTTTAGCCAGGATGGTTTAAAATATAATGAAGTCATTTTAAGTTGCAGA CAACTGATTCCAAACTAGTAATGTCTTTTCCTGAAAAGGGCAAAACAGCTGCACAGGATTTTGCTTGTACTAAAGAGGAGCATCTTACAA TTGTTCTCTTTTCTCAGTTATCTCCCTCCTCAACAGAGTGTGAACAACCATACAGGTGTTTATTCTTGTTTTATTCCAGGGAGACTGCTT TTAGGTATAACTACATGTTGACAAGATTAAGTGCTGTGGATATGGCCACGTGTTAAAGGAATCTATACTCGCAATAGGAATAAGCTAATG CCCATTTTCAGAAATAAATTAAATGCTGAAAGTGCCTGTCAGTAAACCTTATGACCAATGAGATATTCCTATACTTTTACACAGCAATAA TTCTTAATAAGACTGGGTTTTTTCCTGCACATGTGAACACACACACACATACACACAGAGAGAGTAAATACATACACATAGTAAATCAAA TCTGTTCACATGCCCACAAAAAACGCTTTTATAGCTTTCAAATATACCTAATCTTGTTTACATTAACATTTCTTAATTTGATCTTTCTAA CTTGCAGAACGTTAAGAACACAAATCTGAACATTAAGTTTATCTTCAGTGAACACTATTGCATATGGTAATTATAATTTCCAGATAAAAA GTTGACTGTCATTTGCCCCAAACTTATGAAACAGTATGTATGATTCAAAAAGTTTTGCTCAGTTAAAAACACCAATTTATTTGGCGCAAA AGACTGAAGGATATTTGTTTGCTTGTTCATTTTATCCACTCATATCAAACGCACAAATTCATCTTTACATTTCTTCATTCCCCTTTCCCC TAATATTTCCTATTATCATCTTAAGAATCATTTTGGAATGAATATTGACAGAATCATTTCTCCCCAAAAAGTCTGTTGAAGTACCACTGA CACTTAGTAAGCCTAGCCTTTAACCATCTTTGCAGTTAGTCCTAAAAATTACCAGATGCACATTCAGAAGCTCACAGGTTTTTTCCTGTA ATTACTGTACTGCTAAAAGTGGAGTCATGGATAGAAATATACAATGAGACTATATGAATAGACATGAACCCTGGAAATTCTCCAACCCTG CCATCTCAGAGCACAAATTCACCCAAACAAGCTACTGAGGCTATCAGTAAAATTATACTCATGGAGAGTCACACATCGGGTAAGGGCAAT TTTAAAAGTAGGACTGTGATTAAACATTCAGGCTTTAGACTTCCATGATGGACTCAGACCACAGGCCTCAAAAAAACATCCACTGTTTTC TCCTCCCAATGTTAGAAAGAAGAAAAGGGAGACGGAAATGTACCAGGATAAGGGGGTAAAATAACCAATTAAGTGTCAAAGGAAAGCTGC TGGGTTCCTTAATCTCACTGAAGTCAAGTCTTCTGACTGGGCTTCTTACCATGTGTTGTCTGAAAAAACTAAAGTACCTTGAAAGGTTAC ACATTCAGCAAACCATGAAGATAATAGCTATTCTTTATTAAACACTGTGTGCCAAGCAATAGACTAGGCAATTTTTAGATACGTTACCTG CAACCTGTACAACATTTCTACACTTTATGGATGGGAAACGGAGACATGGGAAGTGTGGCTGAGTTGTTCATGGATGTAGAAATAGTAAAC GGCAGAGTAGGAAAGTGAAACCGCCTATCTCTGACCTGGAGGTCTGCCTGTATCTTTCCCACTCCACCACACTGCACGTGGGTGTCCCGA AACCACCTTCCCAGATTCCTGACTCTCAGTAATTTTATTATGGACAACATGCATGAGTAGTCATCATATTTTTCAAGTGAAATATCGGGA CATGATATAACACATGACTTAACAATGGTACTGAATATTTGAAATCAGGCCTTTCCCGGAAAATCATGCATGAAGGATCATTATAAACAA ACAATAGCAACCAGTTGTCTCCCCGAACTTGTCACTTTTCTCATAAATGTCTGGCCTGGAGCTCCAAAATCATCCAAATACTTAGTAGCA TTTTAGCCTGAGTACACTTTCTCAGTTCCTCAACTCTTTGTATACCTTTCCACCAATATAGACATTCTAGAATCTGCTTCAGATGCATTT GAAATTTTCACCCCCATGGAACTAGTGATTAATATCAGAGCCCACTCTTGCAGTTGGTAATGGGGTGGCAATCAAACGTTCAGATGATGA TAAAGGAGAGATAATGGATAATTCTTTTTCAGAGTTCTCACTTAACAGCTCTGTTGTGGAATGTTTTAAATAGTCTTATAAATAATTTGT TTATAGTATTGTTGTTAGTTTAATTGAATTTTATGTAAGAAGCTGTCCAACATCAGAGAAATGAAATTCCTCCCACTTTCTGTGTAGAAC AAGGTCTCTGACAGTATTGATTCATGGAAGTACTAATGGACTTAGAAAACATTAAGAGAATGTCATTTCTCATAGTGTTTCTGTTTCTGA AAATGAATCTCCTGAATTATTATCTTTCTCCCTGTTACTTGGCTGGGGAAAGAGATAGAAGCTGTATAAACAAATTCTCTTCCATGCTCA AAGCAAGTGTTCCATGTGCACAACCTGCTGCAGACTGGGGCCCTTCTCAGTTAATTGGGTTTCACAAGCAATAATTTCTCCACAACAAAA ACCACAACTTGAAGTGAGTTGAAAAGAGATCAATAGTGGAAACAGTCGCCTCAGTACTTTTTCTTTCTGGATTTCATCTCTAGAAATTTG AAGTGTTTGAGACAGAGTCCACCCTTTGTGCAAGGCGAGAACCAATGAATGGACTCCTTGTGTGAATTATTGCATCTTCTTCCAAAGCAG GTTCATCAAGACTTTCACAGAGATTCATTTTTGTTGAGAAGTAAGGGTTAATAGGAGGATAGAATTTGGATCCAAATCTAGTGATAAAAG TGTCCAAGCAATCAAAAAGTAAGATATTTTAGGGACATACCAACATCTTCCCTTTCTGCTAATTTCATGCTCCAAAGATATGGCAAAAAA AAAAATCATAAAAAGTGCTTTTGCCCTACTTGTGTTCTAGTTTTCCCATGGCAGAATTTTGTAATTACATCCAGAATATAGTGTATATTT TGTTCCTCAAACTTTATTACATTGGATGGATATTGTTGAACTGGGGCACTGGTGCCTATATTCAAGGCTCTTTCCTATCAACGTGTCTGT CCACGATTTGTTGTGTTTAAAGCTTCATTTTGAAAAATCACTGTCCCCCTGTGGGGTAGTGACTGTATTGTTTTGTTCATGTCTATGTGG GACACATTGCATCACATGGCAAACCAACTCTCTGTGGATGTGAGATAAGTACTTATAAAACCAGCTTGAAAACATCGTCTTATGTATTAT GTCATCCTGCATCATAATGCAATTATGTGTATCATAACATGCTCATTTAAAAAAAGAGAAACCAGCAAATTCATGTTTGTCCATAGAAGA ATGTACTCAGAACTTTGTGTTGTGAAACGATGAGAACAGACCACCTTTAAGATACCCACCTGCCACTTAAAATGACTTAGTTATAATTAG TAGTAGTCTAGACGTTGTTCTTGGTGTGTGGGGGTCAATTCTAACGTCATGTTCTTTTGAATAAATCTCTCAGTCATATTTGAAAAAAAA ATACATGGGAATAAAGAAAAATATCATCTTTGGCCAAATCAAGCAGGCATCTTTTTTCTTTTCCTTGACGTTTAGCTCATTATACGTGGT GATTGGATCACGAGATCTGTCCGTGTGAAAATACAGAAACATCCTTTAGTTTACAAAACAGTTATTCTAGGCTTGAAGCCTCTGAACAGC AAATTGAATAGATGGGCTGCATCTGATTTGCTTTATGGATGTAATTTTACAAAACACTCTTGGGTCTCTGACCCCAGGGAGTTAAGAGTG CCCAGAGGAGGTCCTACACATTAAAGGATAAAGCCCCCCAGTGATGCTGGCAAGCAAATGTGTTGAGTTCTTAAATCTTCATTTGGTTTT CTGTTCAGGATTTTAATTGCAAATGAATTTATTTCTCCAGTTTATCTAAAGACCTAATTTCCCAATAGTTTCCTCTGCATTTATATACTC TGTAGTGTTTAGGCAACCCTGTTATAAGTTTATTAATATTATGTAAGTGTTGTTCTTGTATTTATGTATAGTGTATGTATTGTAAATATA CTCAGAGCTTTTTTCCTTTTACTGTAAAATGGTGATTTTTTTGCCCTATGATAATGTAAAGGGAGACCCTCCTAATGAGATTCTCTCAGA GGATGATTATTCCAGTCTATTCTCAGAGATTTAAATGAACAAGTGTTATTGTTTTTAATGGTGTCTCAGACATATTCTGTTGGTGCATTG CTTTTCTGTATTCAACTTTCCTATGAATTGAGCTGTGAACTGAAATAGAGTTTAAACCTTTAACTGTATGCATTTGTATAATTATCTGAA TGAAGGCATGAAGGTTAAATAAAGCATTTTGTATGGAACAAAA >22898_22898_6_DIS3-KLF12_DIS3_chr13_73345933_ENST00000377767_KLF12_chr13_74420510_ENST00000377669_length(amino acids)=896AA_BP=535 MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIV LQTVLQEVRNRSAPVYKRIRDVTNNQEKHFYTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRN KEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNE ENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGML SKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLS FLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKSPNVH NYPDMEAVPLLLNNVKGEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPVSMTASASSPSSTSTSSSSSSRLASSPTVITSVSSA SSSSTVLTPGPLVASASGVGGQQFLHIIHPVPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQM DPRGLSPRQSKSDSDDDDLPNVTLDSVNETGSTALSIARAVQEVHPSPVSRVRGNRMNNQKFPCSISPFSIESTRRQRRSESPDSRKRRI HRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV -------------------------------------------------------------- >22898_22898_7_DIS3-KLF12_DIS3_chr13_73345933_ENST00000377780_KLF12_chr13_74420510_ENST00000377666_length(transcript)=2785nt_BP=1608nt AAGGGAAGAACCTCCGGGGTTAGGCGTATTCTAGATTGACGCCTTTTGCTGGAAGAGCGCTGCTGGGGTTAGGATTCTGCGCGGCGAGGC AAGATGCTCAAGTCCAAGACGTTCTTAAAAAAGACCCGGGCGGGCGGCGTGATGAAGATCGTGCGCGAGCACTACCTGCGAGACGACATC GGCTGCGGTGCGCCCGGGTGCGCAGCGTGTGGAGGGGCGCACGAGGGGCCGGCCCTGGAGCCGCAGCCCCAGGACCCGGCGAGCAGCGTC TGCCCGCAACCGCACTACTTGCTGCCCGACACTAATGTGTTACTGCACCAGATTGTAAGTGCCTGGAGGCCGGGGACCTGGGCTTCTGTG GCCTCCAGCCTGCGACTCCCAGGCAGCTTAGAAACCTATGTAGAACAAGAACAGGGAGAAAATGCTAATGACAGGAATGATAGAGCGATT CGAGTAGCAGCAAAATGGTACAATGAACATTTGAAAAAAATGTCAGCAGACAACCAGCTGCAAGTTATCTTCATAACAAATGACAGGAGA AACAAAGAGAAAGCCATAGAAGAAGGAATACCAGCTTTCACTTGTGAAGAATATGTAAAGAGCCTAACTGCTAACCCCGAACTCATAGAT CGTCTTGCTTGTTTGTCTGAAGAAGGGAATGAAATAGAAAGTGGAAAAATAATATTTTCAGAGCATCTTCCCTTAAGTAAGCTACAGCAA GGCATAAAATCTGGTACATACCTTCAAGGAACATTTAGAGCTAGCAGGGAAAATTACTTGGAAGCTACAGTATGGATTCATGGCGACAAT GAAGAAAATAAAGAGATAATCTTACAGGGACTTAAACATTTAAACAGAGCTGTTCACGAAGATATTGTGGCTGTGGAGCTTCTCCCCAAG AGTCAGTGGGTAGCACCATCTTCTGTGGTTTTACATGATGAAGGTCAAAATGAAGAAGATGTGGAGAAAGAAGAAGAGACAGAACGAATG CTTAAGACTGCTGTAAGCGAGAAAATGTTGAAGCCTACAGGTAGAGTTGTAGGAATAATAAAAAGGAATTGGAGACCATATTGTGGCATG CTTTCCAAGTCTGACATTAAGGAGTCAAGAAGACATCTCTTTACACCTGCTGATAAGAGAATCCCTCGAATTCGCATAGAAACCAGACAG GCTTCCACATTAGAAGGACGGAGAATTATTGTTGCTATTGATGGTTGGCCCAGAAATTCCAGATATCCAAATGGACACTTTGTGAGAAAT TTAGGTGATGTTGGAGAGAAAGAGACTGAAACAGAAGTTTTGTTACTTGAACACGATGTTCCCCATCAGCCTTTTTCACAGGCTGTTCTT AGTTTTCTGCCAAAGATGCCCTGGAGCATTACTGAAAAGGACATGAAAAACCGAGAAGACCTGAGGCATCTGTGTATTTGTAGTGTAGAC CCACCAGGATGTACTGATATAGACGATGCTCTACATTGTCGAGAACTCGAAAATGGAAATTTGGAGGTTGGTGTTCATATTGCTGATGTG AGCCATTTTATTAGGCCAGGAAATGCCTTGGATCAAGAATCAGCCAGAAGAGGAACAACTGTGTATCTTTGTGAAAAGTCTCCAAACGTC CACAACTATCCCGATATGGAAGCCGTTCCCCTGTTGCTAAATAATGTGAAAGGGGAGCCCCCGGAGGACTCGTTATCTGTAGATCACTTC CAAACACAAACTGAGCCAGTGGACTTGTCAATAAACAAAGCCAGGACGTCCCCTACTGCCGTTTCATCCTCCCCAGTTTCCATGACAGCA TCTGCCTCCTCACCTTCTTCAACTTCAACCTCTTCATCGTCTTCTAGTCGTCTAGCCTCATCCCCAACTGTTATCACATCAGTATCTTCA GCGTCATCTTCGTCAACAGTATTAACTCCAGGGCCCCTTGTGGCCTCTGCATCTGGTGTTGGAGGCCAGCAGTTTTTGCACATTATCCAT CCCGTACCGCCTTCAAGTCCCATGAATTTACAGTCTAACAAACTGAGTCATGTTCACCGCATCCCCGTGGTGGTACAGTCGGTGCCTGTT GTCTACACAGCTGTAAGGTCACCTGGAAATGTGAACAACACTATTGTCGTGCCGCTTTTGGAGGATGGGAGAGGCCATGGCAAAGCACAA ATGGACCCCCGAGGCCTATCTCCCAGACAAAGTAAAAGTGACAGTGATGATGATGACCTGCCAAATGTGACCTTAGATAGCGTTAATGAA ACTGGATCTACGGCCCTTTCCATAGCCAGAGCAGTACAAGAGGTACATCCGTCCCCAGTATCAAGGGTCCGGGGCAATCGAATGAATAAT CAAAAGTTTCCTTGTTCAATTTCACCATTTAGTATTGAGAGCACAAGACGCCAGAGACGGTCTGAATCCCCAGACTCCAGAAAACGGCGT ATCCACAGATGTGATTTTGAGGGATGCAACAAAGTGTACACAAAAAGTTCTCACCTGAAGGCTCACCGGAGGACACATACAGGAGAGAAA CCTTACAAGTGTACCTGGGAAGGCTGCACCTGGAAGTTCGCTCGTTCAGATGAACTGACGAGGCATTACCGCAAACATACGGGAGTGAAG CCATTCAAGTGCGCGGACTGTGATCGCAGCTTTTCCCGGTCAGATCATTTGGCCCTGCACCGCCGGAGGCATATGTTGGTGTGAGGAATG CTACCTGTCCAGCTGAGCGTAAGAGCTGGATCTCTTAGCGGCACCCAATTCAGCAGGGCTGAATCCCCTTCACAGTGTTAACACA >22898_22898_7_DIS3-KLF12_DIS3_chr13_73345933_ENST00000377780_KLF12_chr13_74420510_ENST00000377666_length(amino acids)=866AA_BP=505 MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIVSAWRPGTWASVA SSLRLPGSLETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDR LACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKS QWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQA STLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDP PGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKSPNVHNYPDMEAVPLLLNNVKGEPPEDSLSVDHFQ TQTEPVDLSINKARTSPTAVSSSPVSMTASASSPSSTSTSSSSSSRLASSPTVITSVSSASSSSTVLTPGPLVASASGVGGQQFLHIIHP VPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQMDPRGLSPRQSKSDSDDDDLPNVTLDSVNET GSTALSIARAVQEVHPSPVSRVRGNRMNNQKFPCSISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKP YKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV -------------------------------------------------------------- >22898_22898_8_DIS3-KLF12_DIS3_chr13_73345933_ENST00000377780_KLF12_chr13_74420510_ENST00000377669_length(transcript)=12095nt_BP=1608nt AAGGGAAGAACCTCCGGGGTTAGGCGTATTCTAGATTGACGCCTTTTGCTGGAAGAGCGCTGCTGGGGTTAGGATTCTGCGCGGCGAGGC AAGATGCTCAAGTCCAAGACGTTCTTAAAAAAGACCCGGGCGGGCGGCGTGATGAAGATCGTGCGCGAGCACTACCTGCGAGACGACATC GGCTGCGGTGCGCCCGGGTGCGCAGCGTGTGGAGGGGCGCACGAGGGGCCGGCCCTGGAGCCGCAGCCCCAGGACCCGGCGAGCAGCGTC TGCCCGCAACCGCACTACTTGCTGCCCGACACTAATGTGTTACTGCACCAGATTGTAAGTGCCTGGAGGCCGGGGACCTGGGCTTCTGTG GCCTCCAGCCTGCGACTCCCAGGCAGCTTAGAAACCTATGTAGAACAAGAACAGGGAGAAAATGCTAATGACAGGAATGATAGAGCGATT CGAGTAGCAGCAAAATGGTACAATGAACATTTGAAAAAAATGTCAGCAGACAACCAGCTGCAAGTTATCTTCATAACAAATGACAGGAGA AACAAAGAGAAAGCCATAGAAGAAGGAATACCAGCTTTCACTTGTGAAGAATATGTAAAGAGCCTAACTGCTAACCCCGAACTCATAGAT CGTCTTGCTTGTTTGTCTGAAGAAGGGAATGAAATAGAAAGTGGAAAAATAATATTTTCAGAGCATCTTCCCTTAAGTAAGCTACAGCAA GGCATAAAATCTGGTACATACCTTCAAGGAACATTTAGAGCTAGCAGGGAAAATTACTTGGAAGCTACAGTATGGATTCATGGCGACAAT GAAGAAAATAAAGAGATAATCTTACAGGGACTTAAACATTTAAACAGAGCTGTTCACGAAGATATTGTGGCTGTGGAGCTTCTCCCCAAG AGTCAGTGGGTAGCACCATCTTCTGTGGTTTTACATGATGAAGGTCAAAATGAAGAAGATGTGGAGAAAGAAGAAGAGACAGAACGAATG CTTAAGACTGCTGTAAGCGAGAAAATGTTGAAGCCTACAGGTAGAGTTGTAGGAATAATAAAAAGGAATTGGAGACCATATTGTGGCATG CTTTCCAAGTCTGACATTAAGGAGTCAAGAAGACATCTCTTTACACCTGCTGATAAGAGAATCCCTCGAATTCGCATAGAAACCAGACAG GCTTCCACATTAGAAGGACGGAGAATTATTGTTGCTATTGATGGTTGGCCCAGAAATTCCAGATATCCAAATGGACACTTTGTGAGAAAT TTAGGTGATGTTGGAGAGAAAGAGACTGAAACAGAAGTTTTGTTACTTGAACACGATGTTCCCCATCAGCCTTTTTCACAGGCTGTTCTT AGTTTTCTGCCAAAGATGCCCTGGAGCATTACTGAAAAGGACATGAAAAACCGAGAAGACCTGAGGCATCTGTGTATTTGTAGTGTAGAC CCACCAGGATGTACTGATATAGACGATGCTCTACATTGTCGAGAACTCGAAAATGGAAATTTGGAGGTTGGTGTTCATATTGCTGATGTG AGCCATTTTATTAGGCCAGGAAATGCCTTGGATCAAGAATCAGCCAGAAGAGGAACAACTGTGTATCTTTGTGAAAAGTCTCCAAACGTC CACAACTATCCCGATATGGAAGCCGTTCCCCTGTTGCTAAATAATGTGAAAGGGGAGCCCCCGGAGGACTCGTTATCTGTAGATCACTTC CAAACACAAACTGAGCCAGTGGACTTGTCAATAAACAAAGCCAGGACGTCCCCTACTGCCGTTTCATCCTCCCCAGTTTCCATGACAGCA TCTGCCTCCTCACCTTCTTCAACTTCAACCTCTTCATCGTCTTCTAGTCGTCTAGCCTCATCCCCAACTGTTATCACATCAGTATCTTCA GCGTCATCTTCGTCAACAGTATTAACTCCAGGGCCCCTTGTGGCCTCTGCATCTGGTGTTGGAGGCCAGCAGTTTTTGCACATTATCCAT CCCGTACCGCCTTCAAGTCCCATGAATTTACAGTCTAACAAACTGAGTCATGTTCACCGCATCCCCGTGGTGGTACAGTCGGTGCCTGTT GTCTACACAGCTGTAAGGTCACCTGGAAATGTGAACAACACTATTGTCGTGCCGCTTTTGGAGGATGGGAGAGGCCATGGCAAAGCACAA ATGGACCCCCGAGGCCTATCTCCCAGACAAAGTAAAAGTGACAGTGATGATGATGACCTGCCAAATGTGACCTTAGATAGCGTTAATGAA ACTGGATCTACGGCCCTTTCCATAGCCAGAGCAGTACAAGAGGTACATCCGTCCCCAGTATCAAGGGTCCGGGGCAATCGAATGAATAAT CAAAAGTTTCCTTGTTCAATTTCACCATTTAGTATTGAGAGCACAAGACGCCAGAGACGGTCTGAATCCCCAGACTCCAGAAAACGGCGT ATCCACAGATGTGATTTTGAGGGATGCAACAAAGTGTACACAAAAAGTTCTCACCTGAAGGCTCACCGGAGGACACATACAGGAGAGAAA CCTTACAAGTGTACCTGGGAAGGCTGCACCTGGAAGTTCGCTCGTTCAGATGAACTGACGAGGCATTACCGCAAACATACGGGAGTGAAG CCATTCAAGTGCGCGGACTGTGATCGCAGCTTTTCCCGGTCAGATCATTTGGCCCTGCACCGCCGGAGGCATATGTTGGTGTGAGGAATG CTACCTGTCCAGCTGAGCGTAAGAGCTGGATCTCTTAGCGGCACCCAATTCAGCAGGGCTGAATCCCCTTCACAGTGTTAACACAAAAGG GCATCACCATCCCACGATGTCTGAAACCAGAGCAGGAAAAAGAAGGCACACTTCTTTTGGTCTGAAGGTAACCCCCATCATGACTAGACG AGAACCGTCTTTACCCGGGCCTGGGAGCTCAGTGACATAAATGCTGAAGAGACAGGCATTGTTTTCCGTGCTGTGTCCTCTGCCATTTAA AGATGTTTGTAGCTTGTACATTTTCTGAGCTGTCAGACATTTTGTTATTGATACCTTAAAGGTCACCTACCACAAATTGATGGCTAGAGC AAGACCTTTTAAATTTGGATGAATCTCCCATCATCCCATCCCTTAACCCCTTTTTACAGAAATTTTAGTTACAATCTGAGTAAGCTAGAA CACACATCCAATCTGTTACCAGCAAGCAGCATGAAAGTAGAAACGAAGAAGCAGATGGAGAGGTCCCATTACCTGCAAAGAAAGGGCACT CAGGCAGCCCTTTGCAATCGCGATGGCAGCCACTAGATATCACTCTCAACTTGTCATTCTGCCATGCCCTGAAGAAAACCAACATTGAAT CTTTCATTTGTTTGTCGTTGATTGTTTTTGTTTTGTTTCGATTCTGTTTTGTTCATCTGTTCGAGCAGAGGGGCAGTTGAAGTCTCGTCC TGGTCTCTGCCCTGGCATGGACTGGCACAGAGGTGTTCTGTAGTTGAATAGGAAGAGCCTGTCTAAAAAACTACTGCCCCACTTCAAATT GCAGTGTTCTGTCACCTAGGCATCATCTCTTCCTGCCCCTAGTATTTGATTACAAGGAACCAGGGGAAAAAAACTTTCTTAGACACACTG GCACCAAGGTAAGAGGTGGGGCTGCCCAGGCAAAGTCAGTGAACATGAAAACTCAGACAAAGCAGAGATGGAAATAATGCGCCTCTTGAG GAGAAAAGCAATAATGAATAAAAGGACTTTCCTACAATAACTTCACTGAGGACTCACGTTACCAATTTTCATACTTACTAAAGGGATTGT AAAAAACACCCCAGCATTTTAGGTGTCTTGGTTCCATTTACAGCACTGAGGTAATCTTTCTGCTGTTTGTTGTCCTGCTTGGTTGAGTAC CACAATTAAAGATTATGCTCCCCTTTTCTTGTTTGAAAACAGTTATTTGGTGACTAGAAAGGCAAGGGAGGCATAGCCGGGAATTAACTC TTCGGTTAATGGGTCAGTTCTCCTTGGAACTGAATCAGTGGAAAGAGAATGCTTCCCATAGAAAGCCCGACATGGTGCTAGTTTCCTCTC TTGGAGAGCCAAGGATAAGTGACTCTCCAATAGGTTCTTCTATACCGATTTCATTTTCTAAACTGTATCAGGACCCAGGTGTCCTGCATT GGCATCTGCAGGGATATTGAACCCACTCATCCTGTGCAGAGGATGAGAGGAAGGTGTTAGTTCCATCAGCCCCATAAAATTATGAACCTT TTTGCAACTAGGAACATATACAGTAAACAAGCAATACATCACCAACGAGCATTCTTTCAGAAAAATTACCATATTTTTGTCCCCACCACA AGCTGGGTTTTTTTCCAGCTTTCTGTGGCTGAGGGGCTGGTGAGATTTTTTGTTGTTATTGTTGTTGTTGCTAGAATTTTTTATAGCTTA GATATAAAAGGTCTCCAACAAAGACCTTTGCAATATATTTTAATTACAAACACTTGATTTTGGGAATTGCACATATTAACCTCACAATAT TACTAGCTCATTTTTAAATGTCTGGACATTCTGAAATAATTTCCGGTTACAGAATTACCCTTTTTAGGATCATCTTCTAATTCAGATAAT CTTATTCTGATGAAGCGAGAACTATGAACGTTGAAACAAGGACAATTTGTGTTGGATGGTATTCAAAAGGAATTTTTTAAAACATTAAGC AACAGTGTAATGATTTTCAGGTCAAATTATGGCTTCACAAATATGTGCTCTATATTGTCTGCCAGGTCTCAAAAATTCATCAAGCAATTT CCCTCCAACAAGGGCTGCAGTTCTAGTGATAAATAGCATCTTTAGCTGCACAGTCTACTACTCATCAACCAGTGGGTTTTTTTTAGCACC TGGAAAGTTTTTTTGTACTATATGCAACTCCTACTTCACATTGCCTGTGACCATTCAGAATAGAAAAAGGTCTGTTGATGCATGCCAGTG CTGGTTACTAGTCAGTGACAGAGAACACAGAGAGGGACAAACACAGCCATGAACCCCCTGGCACTAGTACCAGCACCTAGTTGGCAAGTA GTGGGTGCATCTCTCAAGTGAAGTGTAGATTTGTATTTAGTCCTGCTTGCTCTCATAAAAAGAGCCAGTTCTTTTCTCTGCTGAAAGATG TCTTGAGAGTATTACAGGTAGACTTGGTTTTTAGAATTCATAAAACTGACAGGCAGGGGAATCTTCCTGAGTGACAGCTTGGTTTAAATT TAGCACAGAACTAGATGAGTTGCACTTTTCTAATAACATAGGATGGATTTGGGGAAGGGAACATTTTCCCTCATCCTCTGAAAGTGGAAA CCAGACTGAGATGGTAAGTTAACTGATAAAACCTGTCAGCATTCCATCATTTTCCCCTTTTGACGTATCAGTACTTCTAAGAAGGGATCT AAGCACAATTAAGTGAATTGAGTCCCTGGTCTAGCCTCAGGAACTGAAACTTCTTTGGGGCTTGTCTTGAGACGTGGCAAATTCTCCTTG GTGAGTTTTCTAAAAGTATTTCCCCATGGAAAGGAGAAAGTGGTTTGGGACAGAAAGAAATGGAATGTCTTCAGTCATGGAAGAGCCTCC ATTTCATCTCATGTCCATTTCTAGCCTCTTTCAAAAAGCACAGTGCATCATGAGCAACAGAAAAGCAGTAGAATCCTAAAGGACATAACA GTTGTTCCGTAACTAGAAGCATTCTTTGATTTTAAATTTGAAGCTGTTCAGTTTGCAGCTGGGGATATGTGCATGGTTGGGAACTTATAC ACATAGAGCCATTAACTACTTAAGCAGCTGCAGTAGACCTGATTTTCTGTTTGCAGTATAGAGATTGATTTCAAGGGAGTTACATTATTT GAAAAGTTATGACTTTCAGCCTTTGAGGTTTTAAGAATCCCTTTTCATGGTCTGATCTTAAGTTGTTTGAAAAAAGATTCACGCTTCTGC ATCCACCTCTGCCCTCATTCTGTCAATTGTGTGTGGACTCTGAGAAGCCTGCTTGATAACTTGTCTTAAGTTCTATTAAGGCAGTTAGAC TGAGATTTCTAATGACTTCACCATAAAGATTATACTTCTGCCTGGCGTCGTTTCTATAAAACACTATAGGACATTTGTTTTCAAAAGCAG TTGAGTAACAGCAACATAAACCACATTTTTTAAAAAAATGAGCACTTTTCATTCACTTGAAAGCTTAAGTGGGAAAAAGGAAGATGATTG TCAGGGGAAAAACTTACAAAATGCTACAGTGTTTACAAATGCCAGTTCCAGGTGATTAGAAAGGCCGTTTTCATTATGGTTCAGATTTGG AATAGCTTATGCAAAGATTGTGTTCATTTTTATACAATTCTTTTTAACTTTAAATTGCCATCTGTGTTTTAAACATAATTCTGCACTTTG GAATCAGTTCATTAGAATGATAACATTTATATGGATAAAGATGCAGTATTCCTTATTCTGTACTTGATTTATTATACTTACCAAAGCTGC AACTGAATAAATCTGGTGAGGTGAGGCCTTCAAAATGTATTAATACGCCTTTGTTATGTTGTTATGACTGCTTAGAAATGTAGCCATGAT GTTGTTCTAAAGATGTCTTAACATTTATAGTGAGGATTGACAGAAATTAAGCAGTGTTAAGAATACCAGCATCCATGTTACAGTCTGCGT ATAAGGGACTGAATGTGAGGTAACTCTTATGAATCATAATAGGCCCAGAAAGCCTTAATATTCATAGTTCATAATCCAGTCTCAGATTTT GCTCTTCAATGTTGCCTGTAAACTTAGCAGGTAAATGTATTCTAGTATAAAACATCATTGACCAAATCTCTTCCTTTAGTTTTTCTGAGG TAGTGCATCCCATTAAAAAAGTCTCTTCAATTAGATTTGGCTTTAGTTTAGAAAGGGGTTTGGTAAGTCATGTCTTCCATATGACATTTC TACTCATCCCCACACTGCCTTCCACTTAACCTGTACAGACAGCCCCAACACATGCACATGTGTGTACACAACTGTATATGCAGCAGCCAG TGGGCTAACAAATATCAGCAAAGAACTTTTTTAAAAAGAATTTGTAATAATCCGTGCTGTCTAGAAATGTGAGTTACTTACCTTATTAGG AAACCGGCTTATAATACTATATATGACTCTGCCTGCATTTTATAGTTAAGAAATGTACATAAAAATTGCTATATTTTCACAGTTTCATTA TAATGTCTGTTTAGTAACCCATGTCCACTGATACTTTAAATATGCTAATTACTGAGCAATTGCAATAGAAATCCAGATTTTCATAAGAAA ATGAAATAGAAGGATACTGCATCTTTAAAAAATAGAGTGAAGATATTTTACTGTATTCGTAACATATGTGATAGTGGAAAAAGTATTTTC AAACTCACAAATTTTACAGAGGTTGTAAATAGTTTGATGAAGTATGTTGGGAAAGAGAGCTTCTAGTTTTCATCACAATAAAAAGAAAAA ACTTGTTCAGATATGCCTTGTATATCTTACACACAATGAGTGAAATTGCCATGGGAACTCTGTCCAACTTTGTCAGAGCATGCTCTTCGT GTTCTGTTCAAAATAGAGTGGCCACTTGTCATGGTTTAGCCAGGATGGTTTAAAATATAATGAAGTCATTTTAAGTTGCAGACAACTGAT TCCAAACTAGTAATGTCTTTTCCTGAAAAGGGCAAAACAGCTGCACAGGATTTTGCTTGTACTAAAGAGGAGCATCTTACAATTGTTCTC TTTTCTCAGTTATCTCCCTCCTCAACAGAGTGTGAACAACCATACAGGTGTTTATTCTTGTTTTATTCCAGGGAGACTGCTTTTAGGTAT AACTACATGTTGACAAGATTAAGTGCTGTGGATATGGCCACGTGTTAAAGGAATCTATACTCGCAATAGGAATAAGCTAATGCCCATTTT CAGAAATAAATTAAATGCTGAAAGTGCCTGTCAGTAAACCTTATGACCAATGAGATATTCCTATACTTTTACACAGCAATAATTCTTAAT AAGACTGGGTTTTTTCCTGCACATGTGAACACACACACACATACACACAGAGAGAGTAAATACATACACATAGTAAATCAAATCTGTTCA CATGCCCACAAAAAACGCTTTTATAGCTTTCAAATATACCTAATCTTGTTTACATTAACATTTCTTAATTTGATCTTTCTAACTTGCAGA ACGTTAAGAACACAAATCTGAACATTAAGTTTATCTTCAGTGAACACTATTGCATATGGTAATTATAATTTCCAGATAAAAAGTTGACTG TCATTTGCCCCAAACTTATGAAACAGTATGTATGATTCAAAAAGTTTTGCTCAGTTAAAAACACCAATTTATTTGGCGCAAAAGACTGAA GGATATTTGTTTGCTTGTTCATTTTATCCACTCATATCAAACGCACAAATTCATCTTTACATTTCTTCATTCCCCTTTCCCCTAATATTT CCTATTATCATCTTAAGAATCATTTTGGAATGAATATTGACAGAATCATTTCTCCCCAAAAAGTCTGTTGAAGTACCACTGACACTTAGT AAGCCTAGCCTTTAACCATCTTTGCAGTTAGTCCTAAAAATTACCAGATGCACATTCAGAAGCTCACAGGTTTTTTCCTGTAATTACTGT ACTGCTAAAAGTGGAGTCATGGATAGAAATATACAATGAGACTATATGAATAGACATGAACCCTGGAAATTCTCCAACCCTGCCATCTCA GAGCACAAATTCACCCAAACAAGCTACTGAGGCTATCAGTAAAATTATACTCATGGAGAGTCACACATCGGGTAAGGGCAATTTTAAAAG TAGGACTGTGATTAAACATTCAGGCTTTAGACTTCCATGATGGACTCAGACCACAGGCCTCAAAAAAACATCCACTGTTTTCTCCTCCCA ATGTTAGAAAGAAGAAAAGGGAGACGGAAATGTACCAGGATAAGGGGGTAAAATAACCAATTAAGTGTCAAAGGAAAGCTGCTGGGTTCC TTAATCTCACTGAAGTCAAGTCTTCTGACTGGGCTTCTTACCATGTGTTGTCTGAAAAAACTAAAGTACCTTGAAAGGTTACACATTCAG CAAACCATGAAGATAATAGCTATTCTTTATTAAACACTGTGTGCCAAGCAATAGACTAGGCAATTTTTAGATACGTTACCTGCAACCTGT ACAACATTTCTACACTTTATGGATGGGAAACGGAGACATGGGAAGTGTGGCTGAGTTGTTCATGGATGTAGAAATAGTAAACGGCAGAGT AGGAAAGTGAAACCGCCTATCTCTGACCTGGAGGTCTGCCTGTATCTTTCCCACTCCACCACACTGCACGTGGGTGTCCCGAAACCACCT TCCCAGATTCCTGACTCTCAGTAATTTTATTATGGACAACATGCATGAGTAGTCATCATATTTTTCAAGTGAAATATCGGGACATGATAT AACACATGACTTAACAATGGTACTGAATATTTGAAATCAGGCCTTTCCCGGAAAATCATGCATGAAGGATCATTATAAACAAACAATAGC AACCAGTTGTCTCCCCGAACTTGTCACTTTTCTCATAAATGTCTGGCCTGGAGCTCCAAAATCATCCAAATACTTAGTAGCATTTTAGCC TGAGTACACTTTCTCAGTTCCTCAACTCTTTGTATACCTTTCCACCAATATAGACATTCTAGAATCTGCTTCAGATGCATTTGAAATTTT CACCCCCATGGAACTAGTGATTAATATCAGAGCCCACTCTTGCAGTTGGTAATGGGGTGGCAATCAAACGTTCAGATGATGATAAAGGAG AGATAATGGATAATTCTTTTTCAGAGTTCTCACTTAACAGCTCTGTTGTGGAATGTTTTAAATAGTCTTATAAATAATTTGTTTATAGTA TTGTTGTTAGTTTAATTGAATTTTATGTAAGAAGCTGTCCAACATCAGAGAAATGAAATTCCTCCCACTTTCTGTGTAGAACAAGGTCTC TGACAGTATTGATTCATGGAAGTACTAATGGACTTAGAAAACATTAAGAGAATGTCATTTCTCATAGTGTTTCTGTTTCTGAAAATGAAT CTCCTGAATTATTATCTTTCTCCCTGTTACTTGGCTGGGGAAAGAGATAGAAGCTGTATAAACAAATTCTCTTCCATGCTCAAAGCAAGT GTTCCATGTGCACAACCTGCTGCAGACTGGGGCCCTTCTCAGTTAATTGGGTTTCACAAGCAATAATTTCTCCACAACAAAAACCACAAC TTGAAGTGAGTTGAAAAGAGATCAATAGTGGAAACAGTCGCCTCAGTACTTTTTCTTTCTGGATTTCATCTCTAGAAATTTGAAGTGTTT GAGACAGAGTCCACCCTTTGTGCAAGGCGAGAACCAATGAATGGACTCCTTGTGTGAATTATTGCATCTTCTTCCAAAGCAGGTTCATCA AGACTTTCACAGAGATTCATTTTTGTTGAGAAGTAAGGGTTAATAGGAGGATAGAATTTGGATCCAAATCTAGTGATAAAAGTGTCCAAG CAATCAAAAAGTAAGATATTTTAGGGACATACCAACATCTTCCCTTTCTGCTAATTTCATGCTCCAAAGATATGGCAAAAAAAAAAATCA TAAAAAGTGCTTTTGCCCTACTTGTGTTCTAGTTTTCCCATGGCAGAATTTTGTAATTACATCCAGAATATAGTGTATATTTTGTTCCTC AAACTTTATTACATTGGATGGATATTGTTGAACTGGGGCACTGGTGCCTATATTCAAGGCTCTTTCCTATCAACGTGTCTGTCCACGATT TGTTGTGTTTAAAGCTTCATTTTGAAAAATCACTGTCCCCCTGTGGGGTAGTGACTGTATTGTTTTGTTCATGTCTATGTGGGACACATT GCATCACATGGCAAACCAACTCTCTGTGGATGTGAGATAAGTACTTATAAAACCAGCTTGAAAACATCGTCTTATGTATTATGTCATCCT GCATCATAATGCAATTATGTGTATCATAACATGCTCATTTAAAAAAAGAGAAACCAGCAAATTCATGTTTGTCCATAGAAGAATGTACTC AGAACTTTGTGTTGTGAAACGATGAGAACAGACCACCTTTAAGATACCCACCTGCCACTTAAAATGACTTAGTTATAATTAGTAGTAGTC TAGACGTTGTTCTTGGTGTGTGGGGGTCAATTCTAACGTCATGTTCTTTTGAATAAATCTCTCAGTCATATTTGAAAAAAAAATACATGG GAATAAAGAAAAATATCATCTTTGGCCAAATCAAGCAGGCATCTTTTTTCTTTTCCTTGACGTTTAGCTCATTATACGTGGTGATTGGAT CACGAGATCTGTCCGTGTGAAAATACAGAAACATCCTTTAGTTTACAAAACAGTTATTCTAGGCTTGAAGCCTCTGAACAGCAAATTGAA TAGATGGGCTGCATCTGATTTGCTTTATGGATGTAATTTTACAAAACACTCTTGGGTCTCTGACCCCAGGGAGTTAAGAGTGCCCAGAGG AGGTCCTACACATTAAAGGATAAAGCCCCCCAGTGATGCTGGCAAGCAAATGTGTTGAGTTCTTAAATCTTCATTTGGTTTTCTGTTCAG GATTTTAATTGCAAATGAATTTATTTCTCCAGTTTATCTAAAGACCTAATTTCCCAATAGTTTCCTCTGCATTTATATACTCTGTAGTGT TTAGGCAACCCTGTTATAAGTTTATTAATATTATGTAAGTGTTGTTCTTGTATTTATGTATAGTGTATGTATTGTAAATATACTCAGAGC TTTTTTCCTTTTACTGTAAAATGGTGATTTTTTTGCCCTATGATAATGTAAAGGGAGACCCTCCTAATGAGATTCTCTCAGAGGATGATT ATTCCAGTCTATTCTCAGAGATTTAAATGAACAAGTGTTATTGTTTTTAATGGTGTCTCAGACATATTCTGTTGGTGCATTGCTTTTCTG TATTCAACTTTCCTATGAATTGAGCTGTGAACTGAAATAGAGTTTAAACCTTTAACTGTATGCATTTGTATAATTATCTGAATGAAGGCA TGAAGGTTAAATAAAGCATTTTGTATGGAACAAAA >22898_22898_8_DIS3-KLF12_DIS3_chr13_73345933_ENST00000377780_KLF12_chr13_74420510_ENST00000377669_length(amino acids)=866AA_BP=505 MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIVSAWRPGTWASVA SSLRLPGSLETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDR LACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKS QWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQA STLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDP PGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKSPNVHNYPDMEAVPLLLNNVKGEPPEDSLSVDHFQ TQTEPVDLSINKARTSPTAVSSSPVSMTASASSPSSTSTSSSSSSRLASSPTVITSVSSASSSSTVLTPGPLVASASGVGGQQFLHIIHP VPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQMDPRGLSPRQSKSDSDDDDLPNVTLDSVNET GSTALSIARAVQEVHPSPVSRVRGNRMNNQKFPCSISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKP YKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DIS3-KLF12 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DIS3-KLF12 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DIS3-KLF12 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C0013146 | Drug abuse | 1 | CTD_human | |
| Tgene | C0013170 | Drug habituation | 1 | CTD_human | |
| Tgene | C0013222 | Drug Use Disorders | 1 | CTD_human | |
| Tgene | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human | |
| Tgene | C0036341 | Schizophrenia | 1 | CTD_human | |
| Tgene | C0038580 | Substance Dependence | 1 | CTD_human | |
| Tgene | C0038586 | Substance Use Disorders | 1 | CTD_human | |
| Tgene | C0236969 | Substance-Related Disorders | 1 | CTD_human | |
| Tgene | C0740858 | Substance abuse problem | 1 | CTD_human | |
| Tgene | C1510472 | Drug Dependence | 1 | CTD_human | |
| Tgene | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
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