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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARSG-CDK12 (FusionGDB2 ID:HG22901TG51755)

Fusion Gene Summary for ARSG-CDK12

check button Fusion gene summary
Fusion gene informationFusion gene name: ARSG-CDK12
Fusion gene ID: hg22901tg51755
HgeneTgene
Gene symbol

ARSG

CDK12

Gene ID

22901

51755

Gene namearylsulfatase Gcyclin dependent kinase 12
SynonymsUSH4CRK7|CRKR|CRKRS
Cytomap('ARSG')('CDK12')

17q24.2

17q12

Type of geneprotein-codingprotein-coding
Descriptionarylsulfatase GASGcyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000582154, ENST00000448504, 
ENST00000452479, 
Fusion gene scores* DoF score18 X 13 X 7=163836 X 30 X 14=15120
# samples 1855
** MAII scorelog2(18/1638*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(55/15120*10)=-4.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARSG [Title/Abstract] AND CDK12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARSG(66352945)-CDK12(37667782), # samples:3
Anticipated loss of major functional domain due to fusion event.ARSG-CDK12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARSG-CDK12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARSG-CDK12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARSG-CDK12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARSG

GO:0006790

sulfur compound metabolic process

18283100

TgeneCDK12

GO:0046777

protein autophosphorylation

11683387


check buttonFusion gene breakpoints across ARSG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CDK12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-3C-AALI-01AARSGchr17

66352945

-CDK12chr17

37667782

+
ChimerDB4BRCATCGA-3C-AALI-01AARSGchr17

66352945

+CDK12chr17

37667782

+


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Fusion Gene ORF analysis for ARSG-CDK12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000582154ENST00000430627ARSGchr17

66352945

+CDK12chr17

37667782

+
3UTR-3CDSENST00000582154ENST00000447079ARSGchr17

66352945

+CDK12chr17

37667782

+
3UTR-intronENST00000582154ENST00000559545ARSGchr17

66352945

+CDK12chr17

37667782

+
5CDS-intronENST00000448504ENST00000559545ARSGchr17

66352945

+CDK12chr17

37667782

+
5CDS-intronENST00000452479ENST00000559545ARSGchr17

66352945

+CDK12chr17

37667782

+
In-frameENST00000448504ENST00000430627ARSGchr17

66352945

+CDK12chr17

37667782

+
In-frameENST00000448504ENST00000447079ARSGchr17

66352945

+CDK12chr17

37667782

+
In-frameENST00000452479ENST00000430627ARSGchr17

66352945

+CDK12chr17

37667782

+
In-frameENST00000452479ENST00000447079ARSGchr17

66352945

+CDK12chr17

37667782

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448504ARSGchr1766352945+ENST00000430627CDK12chr1737667782+444115007963279827
ENST00000448504ARSGchr1766352945+ENST00000447079CDK12chr1737667782+713715007963306836
ENST00000452479ARSGchr1766352945+ENST00000430627CDK12chr1737667782+34785371032316737
ENST00000452479ARSGchr1766352945+ENST00000447079CDK12chr1737667782+61745371032343746

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448504ENST00000430627ARSGchr1766352945+CDK12chr1737667782+0.004458380.99554163
ENST00000448504ENST00000447079ARSGchr1766352945+CDK12chr1737667782+0.0005736090.99942636
ENST00000452479ENST00000430627ARSGchr1766352945+CDK12chr1737667782+0.0116084420.9883916
ENST00000452479ENST00000447079ARSGchr1766352945+CDK12chr1737667782+0.0023884370.9976115

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Fusion Genomic Features for ARSG-CDK12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARSGchr1766352945+CDK12chr1737667781+2.18E-081
ARSGchr1766352945+CDK12chr1737667781+2.18E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARSG-CDK12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:66352945/chr17:37667782)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDK12chr17:66352945chr17:37667782ENST000004306276141266_12808881482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:66352945chr17:37667782ENST000004470796141266_12808881491.0Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDK12chr17:66352945chr17:37667782ENST00000430627614407_4138881482.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:66352945chr17:37667782ENST00000430627614535_5408881482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:66352945chr17:37667782ENST00000447079614407_4138881491.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:66352945chr17:37667782ENST00000447079614535_5408881491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:66352945chr17:37667782ENST00000430627614727_10208881482.0DomainProtein kinase
TgeneCDK12chr17:66352945chr17:37667782ENST00000447079614727_10208881491.0DomainProtein kinase
TgeneCDK12chr17:66352945chr17:37667782ENST00000430627614733_7418881482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:66352945chr17:37667782ENST00000430627614814_8198881482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:66352945chr17:37667782ENST00000447079614733_7418881491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:66352945chr17:37667782ENST00000447079614814_8198881491.0Nucleotide bindingNote=ATP


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Fusion Gene Sequence for ARSG-CDK12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6894_6894_1_ARSG-CDK12_ARSG_chr17_66352945_ENST00000448504_CDK12_chr17_37667782_ENST00000430627_length(transcript)=4441nt_BP=1500nt
GGCTGCGCCCAGGCCGGCGGGCCCAGCAGCTGCGAACCGCCGGCGCACCACCTGTTTCCGCGCCCGGGGACTTCCCCGGCGGGGCTCAGA
AGTGTGGGATCGGTCGCTTGGCTTCCCCTGGCGTCAGCGACCCAGGGTAACCTCCTCCACTGCTGCGTGCCGTGCAGGCCTGCCTGTGTG
AGAGCCACGTGTGCCGCGCTCTGGGCACAGCCTTGGAAAGTCAGGACCGCGACGGCAGCAGAGCAGAAACCTTACAGAAACATGAAGCCC
TCAACCATCTGCTACTCAGTTATTCGGGGCTGACGGCGGCTTCTAGAACATCCAGGTGTTCTGCAGATGCGAGAACTCATCCTGTAGTCA
CCAGATGGAGTCCCAAACAGCCAAGCAGATGTAAGGCCTGTGCTGTGGCTCTGAGGCCCTGAATACAGAAGGGTCACTTTCTTAGTGGCC
AAAGAGCAGTTGTTGACATTGATGTCTAATTATTGAACACGACCAGTCATTTTACTGAGCTGCGGTGAGGAAACACTGACCATAGAAGAT
CAAGCCAAATGAGGGATTGCAAATTTCCTGATTCTTTTGAATTAGGATTCCAGATGGGGGCCTCATTTCTACAGCCCCCAACATTCCTAT
AGCCGTTATCACTGCCATCACCACTGCCACCAGCATCTTCTTGCAGATTCCACCCCTGCTCCCCAGAGACTTCCTGCTTTGAAAGTGAGC
AGAAAGGAAGCTCTCAGAAAAATCTCTAGTGGTGGCTGCCGTCGCTCCAGACAATCGGAATCCTGCCTTCACCACCATGGGCTGGCTTTT
TCTAAAGGTTTTGTTGGCGGGAGTGAGTTTCTCAGGATTTCTTTATCCTCTTGTGGATTTTTGCATCAGTGGGAAAACAAGAGGACAGAA
GCCAAACTTTGTGATTATTTTGGCCGATGACATGGGGTGGGGTGACCTGGGAGCAAACTGGGCAGAAACAAAGGACACTGCCAACCTTGA
TAAGATGGCTTCGGAGGGAATGAGGTTTGTGGATTTCCATGCAGCTGCCTCCACCTGCTCACCCTCCCGGGCTTCCTTGCTCACCGGCCG
GCTTGGCCTTCGCAATGGAGTCACACGCAACTTTGCAGTCACTTCTGTGGGAGGCCTTCCGCTCAACGAGACCACCTTGGCAGAGGTGCT
GCAGCAGGCGGGTTACGTCACTGGGATAATAGGCAAATGGCATCTTGGACACCACGGCTCTTATCACCCCAACTTCCGTGGTTTTGATTA
CTACTTTGGAATCCCATATAGCCATGATATGGGCTGTACTGATACTCCAGGCTACAACCACCCTCCTTGTCCAGCGTGTCCACAGGGTGA
TGGACCATCAAGGAACCTTCAAAGAGACTGTTACACTGACGTGGCCCTCCCTCTTTATGAAAACCTCAACATTGTGGAGCAGCCGGTGAA
CTTGAGCAGCCTTGCCCAGAAGTATGCTGAGAAAGCAACCCAGTTCATCCAGCGTGCAAGTCGCCCTTACACAAACAAAGTCATTACTTT
GTGGTACCGACCTCCAGAACTACTGCTAGGAGAGGAACGTTACACACCAGCCATAGATGTTTGGAGCTGTGGATGTATTCTTGGGGAACT
ATTCACAAAGAAGCCTATTTTTCAAGCCAATCTGGAACTGGCTCAGCTAGAACTGATCAGCCGACTTTGTGGTAGCCCTTGTCCAGCTGT
GTGGCCTGATGTTATCAAACTGCCCTACTTCAACACCATGAAACCGAAGAAGCAATATCGAAGGCGTCTACGAGAAGAATTCTCTTTCAT
TCCTTCTGCAGCACTTGATTTATTGGACCACATGCTGACACTAGATCCTAGTAAGCGGTGCACAGCTGAACAGACCCTACAGAGCGACTT
CCTTAAAGATGTCGAACTCAGCAAAATGGCTCCTCCAGACCTCCCCCACTGGCAGGATTGCCATGAGTTGTGGAGTAAGAAACGGCGACG
TCAGCGACAAAGTGGTGTTGTAGTCGAAGAGCCACCTCCATCCAAAACTTCTCGAAAAGAAACTACCTCAGGGACAAGTACTGAGCCTGT
GAAGAACAGCAGCCCAGCACCACCTCAGCCTGCTCCTGGCAAGGTGGAGTCTGGGGCTGGGGATGCAATAGGCCTTGCTGACATCACACA
ACAGCTGAATCAAAGTGAATTGGCAGTGTTATTAAACCTGCTGCAGAGCCAAACCGACCTGAGCATCCCTCAAATGGCACAGCTGCTTAA
CATCCACTCCAACCCAGAGATGCAGCAGCAGCTGGAAGCCCTGAACCAATCCATCAGTGCCCTGACGGAAGCTACTTCCCAGCAGCAGGA
CTCAGAGACCATGGCCCCAGAGGAGTCTTTGAAGGAAGCACCCTCTGCCCCAGTGATCCTGCCTTCAGCAGAACAGACGACCCTTGAAGC
TTCAAGCACACCAGCTGACATGCAGAATATATTGGCAGTTCTCTTGAGTCAGCTGATGAAAACCCAAGAGCCAGCAGGCAGTCTGGAGGA
AAACAACAGTGACAAGAACAGTGGGCCACAGGGGCCCCGAAGAACTCCCACAATGCCACAGGAGGAGGCAGCAGAGAAGAGGCCCCCTGA
GCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGAC
AGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTA
CTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTC
TGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAG
TTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCA
ACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCAC
TGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGT
CCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCAT
CCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTG
CTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACT
CTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGAT
CGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGT
TTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTT
TGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTT
TTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTT
CTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGT
GCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTC
TTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCA
GACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTG
GACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAATAACAGCATTTAGCATATTGTTTACAC
ATATATTTTTATGTCAAAAAAAAAACAAAAA

>6894_6894_1_ARSG-CDK12_ARSG_chr17_66352945_ENST00000448504_CDK12_chr17_37667782_ENST00000430627_length(amino acids)=827AA_BP=234
MGWLFLKVLLAGVSFSGFLYPLVDFCISGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRAS
LLTGRLGLRNGVTRNFAVTSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLGHHGSYHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPA
CPQGDGPSRNLQRDCYTDVALPLYENLNIVEQPVNLSSLAQKYAEKATQFIQRASRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC
ILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQT
LQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGL
ADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQ
TTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQEL
NPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHL
GESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYR
GPTRVPPRGGRGRGVPY

--------------------------------------------------------------
>6894_6894_2_ARSG-CDK12_ARSG_chr17_66352945_ENST00000448504_CDK12_chr17_37667782_ENST00000447079_length(transcript)=7137nt_BP=1500nt
GGCTGCGCCCAGGCCGGCGGGCCCAGCAGCTGCGAACCGCCGGCGCACCACCTGTTTCCGCGCCCGGGGACTTCCCCGGCGGGGCTCAGA
AGTGTGGGATCGGTCGCTTGGCTTCCCCTGGCGTCAGCGACCCAGGGTAACCTCCTCCACTGCTGCGTGCCGTGCAGGCCTGCCTGTGTG
AGAGCCACGTGTGCCGCGCTCTGGGCACAGCCTTGGAAAGTCAGGACCGCGACGGCAGCAGAGCAGAAACCTTACAGAAACATGAAGCCC
TCAACCATCTGCTACTCAGTTATTCGGGGCTGACGGCGGCTTCTAGAACATCCAGGTGTTCTGCAGATGCGAGAACTCATCCTGTAGTCA
CCAGATGGAGTCCCAAACAGCCAAGCAGATGTAAGGCCTGTGCTGTGGCTCTGAGGCCCTGAATACAGAAGGGTCACTTTCTTAGTGGCC
AAAGAGCAGTTGTTGACATTGATGTCTAATTATTGAACACGACCAGTCATTTTACTGAGCTGCGGTGAGGAAACACTGACCATAGAAGAT
CAAGCCAAATGAGGGATTGCAAATTTCCTGATTCTTTTGAATTAGGATTCCAGATGGGGGCCTCATTTCTACAGCCCCCAACATTCCTAT
AGCCGTTATCACTGCCATCACCACTGCCACCAGCATCTTCTTGCAGATTCCACCCCTGCTCCCCAGAGACTTCCTGCTTTGAAAGTGAGC
AGAAAGGAAGCTCTCAGAAAAATCTCTAGTGGTGGCTGCCGTCGCTCCAGACAATCGGAATCCTGCCTTCACCACCATGGGCTGGCTTTT
TCTAAAGGTTTTGTTGGCGGGAGTGAGTTTCTCAGGATTTCTTTATCCTCTTGTGGATTTTTGCATCAGTGGGAAAACAAGAGGACAGAA
GCCAAACTTTGTGATTATTTTGGCCGATGACATGGGGTGGGGTGACCTGGGAGCAAACTGGGCAGAAACAAAGGACACTGCCAACCTTGA
TAAGATGGCTTCGGAGGGAATGAGGTTTGTGGATTTCCATGCAGCTGCCTCCACCTGCTCACCCTCCCGGGCTTCCTTGCTCACCGGCCG
GCTTGGCCTTCGCAATGGAGTCACACGCAACTTTGCAGTCACTTCTGTGGGAGGCCTTCCGCTCAACGAGACCACCTTGGCAGAGGTGCT
GCAGCAGGCGGGTTACGTCACTGGGATAATAGGCAAATGGCATCTTGGACACCACGGCTCTTATCACCCCAACTTCCGTGGTTTTGATTA
CTACTTTGGAATCCCATATAGCCATGATATGGGCTGTACTGATACTCCAGGCTACAACCACCCTCCTTGTCCAGCGTGTCCACAGGGTGA
TGGACCATCAAGGAACCTTCAAAGAGACTGTTACACTGACGTGGCCCTCCCTCTTTATGAAAACCTCAACATTGTGGAGCAGCCGGTGAA
CTTGAGCAGCCTTGCCCAGAAGTATGCTGAGAAAGCAACCCAGTTCATCCAGCGTGCAAGTCGCCCTTACACAAACAAAGTCATTACTTT
GTGGTACCGACCTCCAGAACTACTGCTAGGAGAGGAACGTTACACACCAGCCATAGATGTTTGGAGCTGTGGATGTATTCTTGGGGAACT
ATTCACAAAGAAGCCTATTTTTCAAGCCAATCTGGAACTGGCTCAGCTAGAACTGATCAGCCGACTTTGTGGTAGCCCTTGTCCAGCTGT
GTGGCCTGATGTTATCAAACTGCCCTACTTCAACACCATGAAACCGAAGAAGCAATATCGAAGGCGTCTACGAGAAGAATTCTCTTTCAT
TCCTTCTGCAGCACTTGATTTATTGGACCACATGCTGACACTAGATCCTAGTAAGCGGTGCACAGCTGAACAGACCCTACAGAGCGACTT
CCTTAAAGATGTCGAACTCAGCAAAATGGCTCCTCCAGACCTCCCCCACTGGCAGGATTGCCATGAGTTGTGGAGTAAGAAACGGCGACG
TCAGCGACAAAGTGGTGTTGTAGTCGAAGAGCCACCTCCATCCAAAACTTCTCGAAAAGAAACTACCTCAGGGACAAGTACTGAGCCTGT
GAAGAACAGCAGCCCAGCACCACCTCAGCCTGCTCCTGGCAAGGTGGAGTCTGGGGCTGGGGATGCAATAGGCCTTGCTGACATCACACA
ACAGCTGAATCAAAGTGAATTGGCAGTGTTATTAAACCTGCTGCAGAGCCAAACCGACCTGAGCATCCCTCAAATGGCACAGCTGCTTAA
CATCCACTCCAACCCAGAGATGCAGCAGCAGCTGGAAGCCCTGAACCAATCCATCAGTGCCCTGACGGAAGCTACTTCCCAGCAGCAGGA
CTCAGAGACCATGGCCCCAGAGGAGTCTTTGAAGGAAGCACCCTCTGCCCCAGTGATCCTGCCTTCAGCAGAACAGACGACCCTTGAAGC
TTCAAGCACACCAGCTGACATGCAGAATATATTGGCAGTTCTCTTGAGTCAGCTGATGAAAACCCAAGAGCCAGCAGGCAGTCTGGAGGA
AAACAACAGTGACAAGAACAGTGGGCCACAGGGGCCCCGAAGAACTCCCACAATGCCACAGGAGGAGGCAGCAGCATGTCCTCCTCACAT
TCTTCCACCAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGC
CCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGA
GCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGGTTCAG
TGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTC
TCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCC
CTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTGCAAAA
CTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGG
AAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAA
AGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTA
CTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTGGATGG
GCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAATGTTTT
ATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAA
GTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTC
ACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCACCATC
TCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTA
CTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCC
AGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCG
CTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTTTACTT
TTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTC
TGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAA
TAACAGCATTTAGCATATTGTTTACACATATATTTTTATGTCAAAAAAAAAACAAAAACCTTTCAAACAGAGCATTGTGATATTGTCAAA
GAGAAAAACAAATCCTGAAGATACATGGAAATGTAACCTAGTTTAGGGTGGGTATTTTTCTGAAGATACATCAATACCTGACCTTTTTTA
AAAAAATAATTTTAAAACAGCATACTGTGAGGAAGAACAGTATTGACATACCCACATCCCAGCATGTGTACCCTGCCAGTTCTTTTAGGG
ATTTTTCCTCCAAAGAGATTTGGATTTGGTTTTGGTAAAAGGGGTTAAATTGTGCTTCCAGGCAAGAACTTTGCCTTATCATAAACAGGA
AATGAAAAAGGGAAGGGCTGTCAGGATGGGATAATTTGGGAGGCTTCTCATTCTGGCTTCTATTTCTATGTGAGTACCAGCATATAGAGT
GTTTTAAAAACAGATACATGTCATATAATTTATCTGCACAGACTTAGACCTTCAGGAAACATAGGTTAAGCCCCCTTTTACAAAGAAAAA
GTAAACATACTTCAGCATCTTGGAGGGTAGTTTTCAAAACTCAAGTTTCATGTTTCAATGCCAAGTTCTTATTTTAAAAAATAAAATCTA
CTTATAAGAGAAAGGTGCATTACTTAAAAAAAAAAAACTTTAAAGAAATGAAAGAAGAACCCTCTTCAGATACTTACTTGAAGACTGTTT
TCCCCTGTTAATGAGATATAGCTAGATATCGGTGTGTGTATTTCTTTATTATTCTCTGGTTTTTGATCTGGCCTTGCCTCCAGGGCCAAA
CACTGATTTAGAAAGAGAGCCTTCTAGCTATTTTGGCATTGATGGCTTTTTATACCAGTGTGTCCAGTTAGATTTACTAGGCTTACTGAC
ATGCTATTGGTAAATCGCATTAAAGTTCATCTGAACCTTCTGTCTGTTGACTTCTTAGTCCTCAGACATGGGCCTTTGTGTTTTAGAATA
TTTGAATTTGAGTTATTGGGCCCCACTCCCTGTTTTTTATTAAAGAACGTGAGCCTGGGATACTTTCAGAAGTATCTGTTCAATGAAAAA
AAGTTGGTTTCCCATCAAATATGAATAAAATTCTCTATATATTTCATTGTATTTTGGTTATCAGCAGTCATCAATAATGTTTTTCCCTCC
CCTCTCCCACCTCTTATTTTTAATTATGCCAAATATCCTAAATAATATACTTAAGCCTCCATTCCCTCATCCCTACTAGGGAAGGGGGTG
AGTGTATGTGTGAGTGTATGTGTATGTATGATCCCATCTCACCCCCACCCCCATTTTGGGAGTCTTTTAAAATGAAAACAAAGTTTGGTA
GTTTTGACTATTTCTAAAAGCAGAGGAGAAAAAAAAACTTATTTAAATATCCTGGAATCTGTATGGAGGAAGAAAAGGTATTTGTTAATT
TTTCAGTTACGTTATCTATAAACATGATGGAAGTAAAGGTTTGGCAGAATTTCACCTTGACTATTTGAAAATTACAGACCCAATTAATTC
CATTCAAAAGTGGTTTTCGTTTTGTTTTAATTATTGTACAATGAGAGATATTGTCTATTAAATACATTATTTTGAACAGATGAGAAATCT
GATTCTGTTCATGAGTGGGAGGCAAAACTGGTTTGACCGTGATCATTTTTGTGGTTTTGAAAACAAATATACTTGACCCAGTTTCCTTAG
TTTTTTCTTCAACTGTCCATAGGAACGATAAGTATTTGAAAGCAACATCAAATCTATACGTTTAAAGCAGGGCAGTTAGCACAAATTTGC
AAGTAGAACTTCTATTAGCTTATGCCATAGACATCACCCAACCACTTGTATGTGTGTGTGTATATATAATATGCATATATAGTTACCGTG
CTAAAATGGTTACCAGCAGGTTTTGAGAGAGAATGCTGCATCAGAAAAGTGTCAGTTGCCACCTCATTCTCCCTGATTTAGGTTCCTGAC
ACTGATTCCTTTCTCTCTCGTTTTTGACCCCCATTGGGTGTATCTTGTCTATGTACAGATATTTTGTAATATATTAAATTTTTTTCTTTC
AGTTTATAAAAATGGAAAGTGGAGATTGGAAAATTAAATATTTCCTGTTACTATACCACTTTTGCTCCATTGCATTTACTTCTTAATCTG
TACCCCCTGAGCATATCTAATCATGTATAAAGGACGTTTTTCCTCCACTTTATCTTAGGGGTTCTCTGTCTCAGAATCATTATAGACTCA
TTAACTCCCCCTCCCAGCAAAAGGTTATCAGGATTTGAAGAGGTGCTTGAAAACGCTAGACTAGGAACTAGAGAATAAATGAGTTGGGAA
AAACCATGAAATGTGATTTTTTTAAAGTAGAAAAGTTATACAAATAATGGTACCAAACCATCAAAAGAGTTGAGCTTCATGTACCCTGAC
TCCTCCTGACAGGAGAGGTAAGTGGGTTTGAGCTCAACTGTCATCAAGGGAAGTTGGTAAGAGGCTGTTTAGACCCAAAGGATAGTCTTA
AACCAGACTTCACCACCCACCCTACCTCAGTTCCCATGTTATTACATGCAGAGTCAGCATGGGGATTAGTGTACCTACCTTTGCTGAGAT
TTCCCGATGCGTTGCCAATCCAGAAAGTGAATCAAAAAGTTGTTTAAAAGTTAAAATCTCTATTGTTTCCAAAATCTTTCCCATCTCCAC
CTGAAGACAGAATTGCTTCCCCTTCTC

>6894_6894_2_ARSG-CDK12_ARSG_chr17_66352945_ENST00000448504_CDK12_chr17_37667782_ENST00000447079_length(amino acids)=836AA_BP=234
MGWLFLKVLLAGVSFSGFLYPLVDFCISGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRAS
LLTGRLGLRNGVTRNFAVTSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLGHHGSYHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPA
CPQGDGPSRNLQRDCYTDVALPLYENLNIVEQPVNLSSLAQKYAEKATQFIQRASRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC
ILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQT
LQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGL
ADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQ
TTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEG
DLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNR
TFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQ
SSAYGKLYRGPTRVPPRGGRGRGVPY

--------------------------------------------------------------
>6894_6894_3_ARSG-CDK12_ARSG_chr17_66352945_ENST00000452479_CDK12_chr17_37667782_ENST00000430627_length(transcript)=3478nt_BP=537nt
GCGCCGGTCGCGCGCCCGCCAGCCTGCCGCCTGGGCTGGGGGTCACGAAAGGTTTGTGGATTTCCATGCAGCTGCCTCCACCTGCTCACC
CTCCCGGGCTTCCTTGCTCACCGGCCGGCTTGGCCTTCGCAATGGAGTCACACGCAACTTTGCAGTCACTTCTGTGGGAGGCCTTCCGCT
CAACGAGACCACCTTGGCAGAGGTGCTGCAGCAGGCGGGTTACGTCACTGGGATAATAGGCAAATGGCATCTTGGACACCACGGCTCTTA
TCACCCCAACTTCCGTGGTTTTGATTACTACTTTGGAATCCCATATAGCCATGATATGGGCTGTACTGATACTCCAGGCTACAACCACCC
TCCTTGTCCAGCGTGTCCACAGGGTGATGGACCATCAAGGAACCTTCAAAGAGACTGTTACACTGACGTGGCCCTCCCTCTTTATGAAAA
CCTCAACATTGTGGAGCAGCCGGTGAACTTGAGCAGCCTTGCCCAGAAGTATGCTGAGAAAGCAACCCAGTTCATCCAGCGTGCAAGTCG
CCCTTACACAAACAAAGTCATTACTTTGTGGTACCGACCTCCAGAACTACTGCTAGGAGAGGAACGTTACACACCAGCCATAGATGTTTG
GAGCTGTGGATGTATTCTTGGGGAACTATTCACAAAGAAGCCTATTTTTCAAGCCAATCTGGAACTGGCTCAGCTAGAACTGATCAGCCG
ACTTTGTGGTAGCCCTTGTCCAGCTGTGTGGCCTGATGTTATCAAACTGCCCTACTTCAACACCATGAAACCGAAGAAGCAATATCGAAG
GCGTCTACGAGAAGAATTCTCTTTCATTCCTTCTGCAGCACTTGATTTATTGGACCACATGCTGACACTAGATCCTAGTAAGCGGTGCAC
AGCTGAACAGACCCTACAGAGCGACTTCCTTAAAGATGTCGAACTCAGCAAAATGGCTCCTCCAGACCTCCCCCACTGGCAGGATTGCCA
TGAGTTGTGGAGTAAGAAACGGCGACGTCAGCGACAAAGTGGTGTTGTAGTCGAAGAGCCACCTCCATCCAAAACTTCTCGAAAAGAAAC
TACCTCAGGGACAAGTACTGAGCCTGTGAAGAACAGCAGCCCAGCACCACCTCAGCCTGCTCCTGGCAAGGTGGAGTCTGGGGCTGGGGA
TGCAATAGGCCTTGCTGACATCACACAACAGCTGAATCAAAGTGAATTGGCAGTGTTATTAAACCTGCTGCAGAGCCAAACCGACCTGAG
CATCCCTCAAATGGCACAGCTGCTTAACATCCACTCCAACCCAGAGATGCAGCAGCAGCTGGAAGCCCTGAACCAATCCATCAGTGCCCT
GACGGAAGCTACTTCCCAGCAGCAGGACTCAGAGACCATGGCCCCAGAGGAGTCTTTGAAGGAAGCACCCTCTGCCCCAGTGATCCTGCC
TTCAGCAGAACAGACGACCCTTGAAGCTTCAAGCACACCAGCTGACATGCAGAATATATTGGCAGTTCTCTTGAGTCAGCTGATGAAAAC
CCAAGAGCCAGCAGGCAGTCTGGAGGAAAACAACAGTGACAAGAACAGTGGGCCACAGGGGCCCCGAAGAACTCCCACAATGCCACAGGA
GGAGGCAGCAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGC
CCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGA
GCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGGTTCAG
TGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTC
TCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCC
CTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTGCAAAA
CTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGG
AAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAA
AGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTA
CTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTGGATGG
GCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAATGTTTT
ATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAA
GTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTC
ACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCACCATC
TCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTA
CTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCC
AGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCG
CTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTTTACTT
TTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTC
TGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAA
TAACAGCATTTAGCATATTGTTTACACATATATTTTTATGTCAAAAAAAAAACAAAAA

>6894_6894_3_ARSG-CDK12_ARSG_chr17_66352945_ENST00000452479_CDK12_chr17_37667782_ENST00000430627_length(amino acids)=737AA_BP=144
MLTGRLGLRNGVTRNFAVTSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLGHHGSYHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPA
CPQGDGPSRNLQRDCYTDVALPLYENLNIVEQPVNLSSLAQKYAEKATQFIQRASRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC
ILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQT
LQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGL
ADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQ
TTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQEL
NPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHL
GESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYR
GPTRVPPRGGRGRGVPY

--------------------------------------------------------------
>6894_6894_4_ARSG-CDK12_ARSG_chr17_66352945_ENST00000452479_CDK12_chr17_37667782_ENST00000447079_length(transcript)=6174nt_BP=537nt
GCGCCGGTCGCGCGCCCGCCAGCCTGCCGCCTGGGCTGGGGGTCACGAAAGGTTTGTGGATTTCCATGCAGCTGCCTCCACCTGCTCACC
CTCCCGGGCTTCCTTGCTCACCGGCCGGCTTGGCCTTCGCAATGGAGTCACACGCAACTTTGCAGTCACTTCTGTGGGAGGCCTTCCGCT
CAACGAGACCACCTTGGCAGAGGTGCTGCAGCAGGCGGGTTACGTCACTGGGATAATAGGCAAATGGCATCTTGGACACCACGGCTCTTA
TCACCCCAACTTCCGTGGTTTTGATTACTACTTTGGAATCCCATATAGCCATGATATGGGCTGTACTGATACTCCAGGCTACAACCACCC
TCCTTGTCCAGCGTGTCCACAGGGTGATGGACCATCAAGGAACCTTCAAAGAGACTGTTACACTGACGTGGCCCTCCCTCTTTATGAAAA
CCTCAACATTGTGGAGCAGCCGGTGAACTTGAGCAGCCTTGCCCAGAAGTATGCTGAGAAAGCAACCCAGTTCATCCAGCGTGCAAGTCG
CCCTTACACAAACAAAGTCATTACTTTGTGGTACCGACCTCCAGAACTACTGCTAGGAGAGGAACGTTACACACCAGCCATAGATGTTTG
GAGCTGTGGATGTATTCTTGGGGAACTATTCACAAAGAAGCCTATTTTTCAAGCCAATCTGGAACTGGCTCAGCTAGAACTGATCAGCCG
ACTTTGTGGTAGCCCTTGTCCAGCTGTGTGGCCTGATGTTATCAAACTGCCCTACTTCAACACCATGAAACCGAAGAAGCAATATCGAAG
GCGTCTACGAGAAGAATTCTCTTTCATTCCTTCTGCAGCACTTGATTTATTGGACCACATGCTGACACTAGATCCTAGTAAGCGGTGCAC
AGCTGAACAGACCCTACAGAGCGACTTCCTTAAAGATGTCGAACTCAGCAAAATGGCTCCTCCAGACCTCCCCCACTGGCAGGATTGCCA
TGAGTTGTGGAGTAAGAAACGGCGACGTCAGCGACAAAGTGGTGTTGTAGTCGAAGAGCCACCTCCATCCAAAACTTCTCGAAAAGAAAC
TACCTCAGGGACAAGTACTGAGCCTGTGAAGAACAGCAGCCCAGCACCACCTCAGCCTGCTCCTGGCAAGGTGGAGTCTGGGGCTGGGGA
TGCAATAGGCCTTGCTGACATCACACAACAGCTGAATCAAAGTGAATTGGCAGTGTTATTAAACCTGCTGCAGAGCCAAACCGACCTGAG
CATCCCTCAAATGGCACAGCTGCTTAACATCCACTCCAACCCAGAGATGCAGCAGCAGCTGGAAGCCCTGAACCAATCCATCAGTGCCCT
GACGGAAGCTACTTCCCAGCAGCAGGACTCAGAGACCATGGCCCCAGAGGAGTCTTTGAAGGAAGCACCCTCTGCCCCAGTGATCCTGCC
TTCAGCAGAACAGACGACCCTTGAAGCTTCAAGCACACCAGCTGACATGCAGAATATATTGGCAGTTCTCTTGAGTCAGCTGATGAAAAC
CCAAGAGCCAGCAGGCAGTCTGGAGGAAAACAACAGTGACAAGAACAGTGGGCCACAGGGGCCCCGAAGAACTCCCACAATGCCACAGGA
GGAGGCAGCAGCATGTCCTCCTCACATTCTTCCACCAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCC
TCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGC
AGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAA
CACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCT
GGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGA
CCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGT
GGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGG
GGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTA
CTAACCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAG
AGCGAGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATG
ATGTTGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGG
ATCATTACATTGAAAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGG
CTCAGGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGT
TTTTTTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGA
ATAAATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCC
AAATAAATTACTCATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCAT
TCTTGGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTC
TCTCTCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGC
CCAAGAACCTGGGATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTA
AAATGTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAG
ATGATGCCTCCATTCCTAGAGGGCTAATAACAGCATTTAGCATATTGTTTACACATATATTTTTATGTCAAAAAAAAAACAAAAACCTTT
CAAACAGAGCATTGTGATATTGTCAAAGAGAAAAACAAATCCTGAAGATACATGGAAATGTAACCTAGTTTAGGGTGGGTATTTTTCTGA
AGATACATCAATACCTGACCTTTTTTAAAAAAATAATTTTAAAACAGCATACTGTGAGGAAGAACAGTATTGACATACCCACATCCCAGC
ATGTGTACCCTGCCAGTTCTTTTAGGGATTTTTCCTCCAAAGAGATTTGGATTTGGTTTTGGTAAAAGGGGTTAAATTGTGCTTCCAGGC
AAGAACTTTGCCTTATCATAAACAGGAAATGAAAAAGGGAAGGGCTGTCAGGATGGGATAATTTGGGAGGCTTCTCATTCTGGCTTCTAT
TTCTATGTGAGTACCAGCATATAGAGTGTTTTAAAAACAGATACATGTCATATAATTTATCTGCACAGACTTAGACCTTCAGGAAACATA
GGTTAAGCCCCCTTTTACAAAGAAAAAGTAAACATACTTCAGCATCTTGGAGGGTAGTTTTCAAAACTCAAGTTTCATGTTTCAATGCCA
AGTTCTTATTTTAAAAAATAAAATCTACTTATAAGAGAAAGGTGCATTACTTAAAAAAAAAAAACTTTAAAGAAATGAAAGAAGAACCCT
CTTCAGATACTTACTTGAAGACTGTTTTCCCCTGTTAATGAGATATAGCTAGATATCGGTGTGTGTATTTCTTTATTATTCTCTGGTTTT
TGATCTGGCCTTGCCTCCAGGGCCAAACACTGATTTAGAAAGAGAGCCTTCTAGCTATTTTGGCATTGATGGCTTTTTATACCAGTGTGT
CCAGTTAGATTTACTAGGCTTACTGACATGCTATTGGTAAATCGCATTAAAGTTCATCTGAACCTTCTGTCTGTTGACTTCTTAGTCCTC
AGACATGGGCCTTTGTGTTTTAGAATATTTGAATTTGAGTTATTGGGCCCCACTCCCTGTTTTTTATTAAAGAACGTGAGCCTGGGATAC
TTTCAGAAGTATCTGTTCAATGAAAAAAAGTTGGTTTCCCATCAAATATGAATAAAATTCTCTATATATTTCATTGTATTTTGGTTATCA
GCAGTCATCAATAATGTTTTTCCCTCCCCTCTCCCACCTCTTATTTTTAATTATGCCAAATATCCTAAATAATATACTTAAGCCTCCATT
CCCTCATCCCTACTAGGGAAGGGGGTGAGTGTATGTGTGAGTGTATGTGTATGTATGATCCCATCTCACCCCCACCCCCATTTTGGGAGT
CTTTTAAAATGAAAACAAAGTTTGGTAGTTTTGACTATTTCTAAAAGCAGAGGAGAAAAAAAAACTTATTTAAATATCCTGGAATCTGTA
TGGAGGAAGAAAAGGTATTTGTTAATTTTTCAGTTACGTTATCTATAAACATGATGGAAGTAAAGGTTTGGCAGAATTTCACCTTGACTA
TTTGAAAATTACAGACCCAATTAATTCCATTCAAAAGTGGTTTTCGTTTTGTTTTAATTATTGTACAATGAGAGATATTGTCTATTAAAT
ACATTATTTTGAACAGATGAGAAATCTGATTCTGTTCATGAGTGGGAGGCAAAACTGGTTTGACCGTGATCATTTTTGTGGTTTTGAAAA
CAAATATACTTGACCCAGTTTCCTTAGTTTTTTCTTCAACTGTCCATAGGAACGATAAGTATTTGAAAGCAACATCAAATCTATACGTTT
AAAGCAGGGCAGTTAGCACAAATTTGCAAGTAGAACTTCTATTAGCTTATGCCATAGACATCACCCAACCACTTGTATGTGTGTGTGTAT
ATATAATATGCATATATAGTTACCGTGCTAAAATGGTTACCAGCAGGTTTTGAGAGAGAATGCTGCATCAGAAAAGTGTCAGTTGCCACC
TCATTCTCCCTGATTTAGGTTCCTGACACTGATTCCTTTCTCTCTCGTTTTTGACCCCCATTGGGTGTATCTTGTCTATGTACAGATATT
TTGTAATATATTAAATTTTTTTCTTTCAGTTTATAAAAATGGAAAGTGGAGATTGGAAAATTAAATATTTCCTGTTACTATACCACTTTT
GCTCCATTGCATTTACTTCTTAATCTGTACCCCCTGAGCATATCTAATCATGTATAAAGGACGTTTTTCCTCCACTTTATCTTAGGGGTT
CTCTGTCTCAGAATCATTATAGACTCATTAACTCCCCCTCCCAGCAAAAGGTTATCAGGATTTGAAGAGGTGCTTGAAAACGCTAGACTA
GGAACTAGAGAATAAATGAGTTGGGAAAAACCATGAAATGTGATTTTTTTAAAGTAGAAAAGTTATACAAATAATGGTACCAAACCATCA
AAAGAGTTGAGCTTCATGTACCCTGACTCCTCCTGACAGGAGAGGTAAGTGGGTTTGAGCTCAACTGTCATCAAGGGAAGTTGGTAAGAG
GCTGTTTAGACCCAAAGGATAGTCTTAAACCAGACTTCACCACCCACCCTACCTCAGTTCCCATGTTATTACATGCAGAGTCAGCATGGG
GATTAGTGTACCTACCTTTGCTGAGATTTCCCGATGCGTTGCCAATCCAGAAAGTGAATCAAAAAGTTGTTTAAAAGTTAAAATCTCTAT
TGTTTCCAAAATCTTTCCCATCTCCACCTGAAGACAGAATTGCTTCCCCTTCTC

>6894_6894_4_ARSG-CDK12_ARSG_chr17_66352945_ENST00000452479_CDK12_chr17_37667782_ENST00000447079_length(amino acids)=746AA_BP=144
MLTGRLGLRNGVTRNFAVTSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLGHHGSYHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPA
CPQGDGPSRNLQRDCYTDVALPLYENLNIVEQPVNLSSLAQKYAEKATQFIQRASRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC
ILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQT
LQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGL
ADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQ
TTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEG
DLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNR
TFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQ
SSAYGKLYRGPTRVPPRGGRGRGVPY

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Fusion Gene PPI Analysis for ARSG-CDK12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARSG-CDK12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARSG-CDK12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARSGC4748364USHER SYNDROME, TYPE IV2GENOMICS_ENGLAND;UNIPROT
HgeneARSGC0027877Neuronal Ceroid-Lipofuscinoses1GENOMICS_ENGLAND
HgeneARSGC1568248Usher Syndrome, Type III1ORPHANET
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human