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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:DIP2C-YY1 (FusionGDB2 ID:HG22982TG7528) |
Fusion Gene Summary for DIP2C-YY1 |
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Fusion gene information | Fusion gene name: DIP2C-YY1 | Fusion gene ID: hg22982tg7528 | Hgene | Tgene | Gene symbol | DIP2C | YY1 | Gene ID | 22982 | 7528 |
Gene name | disco interacting protein 2 homolog C | YY1 transcription factor | |
Synonyms | KIAA0934 | DELTA|GADEVS|INO80S|NF-E1|UCRBP|YIN-YANG-1 | |
Cytomap | ('DIP2C')('YY1') 10p15.3 | 14q32.2 | |
Type of gene | protein-coding | protein-coding | |
Description | disco-interacting protein 2 homolog CDIP2 disco-interacting protein 2 homolog CDIP2 homolog C | transcriptional repressor protein YY1INO80 complex subunit SYY-1Yin and Yang 1 proteindelta transcription factor | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | P25490 | |
Ensembl transtripts involved in fusion gene | ENST00000280886, ENST00000381496, ENST00000540204, | ||
Fusion gene scores | * DoF score | 25 X 15 X 14=5250 | 12 X 7 X 7=588 |
# samples | 27 | 13 | |
** MAII score | log2(27/5250*10)=-4.28128611039002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/588*10)=-2.17730453180791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DIP2C [Title/Abstract] AND YY1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DIP2C(735434)-YY1(100728641), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | DIP2C-YY1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DIP2C-YY1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. DIP2C-YY1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | YY1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 9857059|16260628 |
Tgene | YY1 | GO:0032688 | negative regulation of interferon-beta production | 16260628 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-D8-A1JL-01A | DIP2C | chr10 | 735434 | - | YY1 | chr14 | 100728641 | + |
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Fusion Gene ORF analysis for DIP2C-YY1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000280886 | ENST00000262238 | DIP2C | chr10 | 735434 | - | YY1 | chr14 | 100728641 | + |
intron-3CDS | ENST00000381496 | ENST00000262238 | DIP2C | chr10 | 735434 | - | YY1 | chr14 | 100728641 | + |
intron-3CDS | ENST00000540204 | ENST00000262238 | DIP2C | chr10 | 735434 | - | YY1 | chr14 | 100728641 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DIP2C-YY1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
DIP2C | chr10 | 735433 | - | YY1 | chr14 | 100728640 | + | 7.54E-12 | 1 |
DIP2C | chr10 | 735433 | - | YY1 | chr14 | 100728640 | + | 7.54E-12 | 1 |
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Fusion Protein Features for DIP2C-YY1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:735434/:100728641) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | YY1 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). {ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:24326773, ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DIP2C-YY1 |
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Fusion Gene PPI Analysis for DIP2C-YY1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DIP2C-YY1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DIP2C-YY1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DIP2C | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
Tgene | C4479652 | GABRIELE-DE VRIES SYNDROME | 2 | GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0006826 | Malignant Neoplasms | 1 | CTD_human | |
Tgene | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human | |
Tgene | C0019693 | HIV Infections | 1 | CTD_human | |
Tgene | C0020796 | Profound Mental Retardation | 1 | CTD_human | |
Tgene | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human | |
Tgene | C0027651 | Neoplasms | 1 | CTD_human | |
Tgene | C0086692 | Benign Neoplasm | 1 | CTD_human | |
Tgene | C0235874 | Disease Exacerbation | 1 | CTD_human | |
Tgene | C0917816 | Mental deficiency | 1 | CTD_human | |
Tgene | C3714756 | Intellectual Disability | 1 | CTD_human;GENOMICS_ENGLAND | |
Tgene | C4048328 | cervical cancer | 1 | CTD_human | |
Tgene | C4505456 | HIV Coinfection | 1 | CTD_human |