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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ALDOB-C3 (FusionGDB2 ID:HG229TG718)

Fusion Gene Summary for ALDOB-C3

Fusion gene summary

Fusion gene information	Fusion gene name: ALDOB-C3
	Fusion gene ID: hg229tg718
		Hgene	Tgene
	Gene symbol	ALDOB	C3
	Gene ID	229	718
	Gene name	aldolase, fructose-bisphosphate B	complement C3
	Synonyms	ALDB\|ALDO2	AHUS5\|ARMD9\|ASP\|C3a\|C3b\|CPAMD1\|HEL-S-62p
	Cytomap	('ALDOB')('C3') 9q31.1	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	fructose-bisphosphate aldolase Baldolase 2aldolase B, fructose-bisphosphatasealdolase B, fructose-bisphosphateliver-type aldolase	complement C3C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1C3a anaphylatoxinacylation-stimulating protein cleavage productcomplement component 3complement component C3acomplement component C3bepididymis secretory sperm binding pr
	Modification date	20200329	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000374855, ENST00000468981,
Fusion gene scores	* DoF score	5 X 4 X 4=80	22 X 20 X 8=3520
	# samples	5	22
	** MAII score	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/3520*10)=-4 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ALDOB [Title/Abstract] AND C3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ALDOB(104190751)-C3(6713520), # samples:1
Anticipated loss of major functional domain due to fusion event.	ALDOB-C3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALDOB-C3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ALDOB	GO:0006096	glycolytic process	10625657
Hgene	ALDOB	GO:0006116	NADH oxidation	17576770
Hgene	ALDOB	GO:0030388	fructose 1,6-bisphosphate metabolic process	9244396\|10625657
Tgene	C3	GO:0001934	positive regulation of protein phosphorylation	15833747
Tgene	C3	GO:0010575	positive regulation of vascular endothelial growth factor production	16452172
Tgene	C3	GO:0010828	positive regulation of glucose transmembrane transport	9059512\|15833747
Tgene	C3	GO:0010866	regulation of triglyceride biosynthetic process	10432298
Tgene	C3	GO:0010884	positive regulation of lipid storage	9555951
Tgene	C3	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	15833747

Fusion gene breakpoints across ALDOB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-DD-A4NV-01A	ALDOB	chr9	104190751	-	C3	chr19	6713520	-

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Fusion Gene ORF analysis for ALDOB-C3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000374855	ENST00000599668	ALDOB	chr9	104190751	-	C3	chr19	6713520	-
In-frame	ENST00000374855	ENST00000245907	ALDOB	chr9	104190751	-	C3	chr19	6713520	-
intron-3CDS	ENST00000468981	ENST00000245907	ALDOB	chr9	104190751	-	C3	chr19	6713520	-
intron-intron	ENST00000468981	ENST00000599668	ALDOB	chr9	104190751	-	C3	chr19	6713520	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000374855

ALDOB

chr9

104190751

ENST00000245907

chr19

6713520

4901

504

580

4722

1380

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000374855	ENST00000245907	ALDOB	chr9	104190751	-	C3	chr19	6713520	-	0.005644127	0.99435586

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Fusion Genomic Features for ALDOB-C3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for ALDOB-C3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:104190751/chr19:6713520)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

chr9:104190751

chr19:6713520

ENST00000245907

1518_1661

257

1664.0

Domain

NTR

Tgene

chr9:104190751

chr19:6713520

ENST00000245907

693_728

257

1664.0

Domain

Anaphylatoxin-like

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ALDOB-C3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>3973_3973_1_ALDOB-C3_ALDOB_chr9_104190751_ENST00000374855_C3_chr19_6713520_ENST00000245907_length(transcript)=4901nt_BP=504nt
AAAAACATGATGAGAAGTCTATAAAAATTGTGTGCTACCAAAGATCTGTCTTATTTGGCAGCTGCTGCCTCACCCACAGCTTTTGATATC
TAGGAGGACTCTTCTCTCCCAAACTACCTGTCACCATGGCCCACCGATTTCCAGCCCTCACCCAGGAGCAGAAGAAGGAGCTCTCAGAAA
TTGCCCAGAGCATTGTTGCCAATGGAAAGGGGATCCTGGCTGCAGATGAATCTGTAGGTACCATGGGGAACCGCCTGCAGAGGATCAAGG
TGGAAAACACTGAAGAGAACCGCCGGCAGTTCCGAGAAATCCTCTTCTCTGTGGACAGTTCCATCAACCAGAGCATCGGGGGTGTGATCC
TTTTCCACGAGACCCTCTACCAGAAGGACAGCCAGGGAAAGCTGTTCAGAAACATCCTCAAGGAAAAGGGGATCGTGGTGGGAATCAAGT
TAGACCAAGGAGGTGCTCCTCTTGCAGGAACAAACAAAGAAACCACCATTCAAGGTTCCTCTACGGGAAGAAAGTGGAGGGAACTGCCTT
TGTCATCTTCGGGATCCAGGATGGCGAACAGAGGATTTCCCTGCCTGAATCCCTCAAGCGCATTCCGATTGAGGATGGCTCGGGGGAGGT
TGTGCTGAGCCGGAAGGTACTGCTGGACGGGGTGCAGAACCCCCGAGCAGAAGACCTGGTGGGGAAGTCTTTGTACGTGTCTGCCACCGT
CATCTTGCACTCAGGCAGTGACATGGTGCAGGCAGAGCGCAGCGGGATCCCCATCGTGACCTCTCCCTACCAGATCCACTTCACCAAGAC
ACCCAAGTACTTCAAACCAGGAATGCCCTTTGACCTCATGGTGTTCGTGACGAACCCTGATGGCTCTCCAGCCTACCGAGTCCCCGTGGC
AGTCCAGGGCGAGGACACTGTGCAGTCTCTAACCCAGGGAGATGGCGTGGCCAAACTCAGCATCAACACACACCCCAGCCAGAAGCCCTT
GAGCATCACGGTGCGCACGAAGAAGCAGGAGCTCTCGGAGGCAGAGCAGGCTACCAGGACCATGCAGGCTCTGCCCTACAGCACCGTGGG
CAACTCCAACAATTACCTGCATCTCTCAGTGCTACGTACAGAGCTCAGACCCGGGGAGACCCTCAACGTCAACTTCCTCCTGCGAATGGA
CCGCGCCCACGAGGCCAAGATCCGCTACTACACCTACCTGATCATGAACAAGGGCAGGCTGTTGAAGGCGGGACGCCAGGTGCGAGAGCC
CGGCCAGGACCTGGTGGTGCTGCCCCTGTCCATCACCACCGACTTCATCCCTTCCTTCCGCCTGGTGGCGTACTACACGCTGATCGGTGC
CAGCGGCCAGAGGGAGGTGGTGGCCGACTCCGTGTGGGTGGACGTCAAGGACTCCTGCGTGGGCTCGCTGGTGGTAAAAAGCGGCCAGTC
AGAAGACCGGCAGCCTGTACCTGGGCAGCAGATGACCCTGAAGATAGAGGGTGACCACGGGGCCCGGGTGGTACTGGTGGCCGTGGACAA
GGGCGTGTTCGTGCTGAATAAGAAGAACAAACTGACGCAGAGTAAGATCTGGGACGTGGTGGAGAAGGCAGACATCGGCTGCACCCCGGG
CAGTGGGAAGGATTACGCCGGTGTCTTCTCCGACGCAGGGCTGACCTTCACGAGCAGCAGTGGCCAGCAGACCGCCCAGAGGGCAGAACT
TCAGTGCCCGCAGCCAGCCGCCCGCCGACGCCGTTCCGTGCAGCTCACGGAGAAGCGAATGGACAAAGTCGGCAAGTACCCCAAGGAGCT
GCGCAAGTGCTGCGAGGACGGCATGCGGGAGAACCCCATGAGGTTCTCGTGCCAGCGCCGGACCCGTTTCATCTCCCTGGGCGAGGCGTG
CAAGAAGGTCTTCCTGGACTGCTGCAACTACATCACAGAGCTGCGGCGGCAGCACGCGCGGGCCAGCCACCTGGGCCTGGCCAGGAGTAA
CCTGGATGAGGACATCATTGCAGAAGAGAACATCGTTTCCCGAAGTGAGTTCCCAGAGAGCTGGCTGTGGAACGTTGAGGACTTGAAAGA
GCCACCGAAAAATGGAATCTCTACGAAGCTCATGAATATATTTTTGAAAGACTCCATCACCACGTGGGAGATTCTGGCTGTGAGCATGTC
GGACAAGAAAGGGATCTGTGTGGCAGACCCCTTCGAGGTCACAGTAATGCAGGACTTCTTCATCGACCTGCGGCTACCCTACTCTGTTGT
TCGAAACGAGCAGGTGGAAATCCGAGCCGTTCTCTACAATTACCGGCAGAACCAAGAGCTCAAGGTGAGGGTGGAACTACTCCACAATCC
AGCCTTCTGCAGCCTGGCCACCACCAAGAGGCGTCACCAGCAGACCGTAACCATCCCCCCCAAGTCCTCGTTGTCCGTTCCATATGTCAT
CGTGCCGCTAAAGACCGGCCTGCAGGAAGTGGAAGTCAAGGCTGCTGTCTACCATCATTTCATCAGTGACGGTGTCAGGAAGTCCCTGAA
GGTCGTGCCGGAAGGAATCAGAATGAACAAAACTGTGGCTGTTCGCACCCTGGATCCAGAACGCCTGGGCCGTGAAGGAGTGCAGAAAGA
GGACATCCCACCTGCAGACCTCAGTGACCAAGTCCCGGACACCGAGTCTGAGACCAGAATTCTCCTGCAAGGGACCCCAGTGGCCCAGAT
GACAGAGGATGCCGTCGACGCGGAACGGCTGAAGCACCTCATTGTGACCCCCTCGGGCTGCGGGGAACAGAACATGATCGGCATGACGCC
CACGGTCATCGCTGTGCATTACCTGGATGAAACGGAGCAGTGGGAGAAGTTCGGCCTAGAGAAGCGGCAGGGGGCCTTGGAGCTCATCAA
GAAGGGGTACACCCAGCAGCTGGCCTTCAGACAACCCAGCTCTGCCTTTGCGGCCTTCGTGAAACGGGCACCCAGCACCTGGCTGACCGC
CTACGTGGTCAAGGTCTTCTCTCTGGCTGTCAACCTCATCGCCATCGACTCCCAAGTCCTCTGCGGGGCTGTTAAATGGCTGATCCTGGA
GAAGCAGAAGCCCGACGGGGTCTTCCAGGAGGATGCGCCCGTGATACACCAAGAAATGATTGGTGGATTACGGAACAACAACGAGAAAGA
CATGGCCCTCACGGCCTTTGTTCTCATCTCGCTGCAGGAGGCTAAAGATATTTGCGAGGAGCAGGTCAACAGCCTGCCAGGCAGCATCAC
TAAAGCAGGAGACTTCCTTGAAGCCAACTACATGAACCTACAGAGATCCTACACTGTGGCCATTGCTGGCTATGCTCTGGCCCAGATGGG
CAGGCTGAAGGGGCCTCTTCTTAACAAATTTCTGACCACAGCCAAAGATAAGAACCGCTGGGAGGACCCTGGTAAGCAGCTCTACAACGT
GGAGGCCACATCCTATGCCCTCTTGGCCCTACTGCAGCTAAAAGACTTTGACTTTGTGCCTCCCGTCGTGCGTTGGCTCAATGAACAGAG
ATACTACGGTGGTGGCTATGGCTCTACCCAGGCCACCTTCATGGTGTTCCAAGCCTTGGCTCAATACCAAAAGGACGCCCCTGACCACCA
GGAACTGAACCTTGATGTGTCCCTCCAACTGCCCAGCCGCAGCTCCAAGATCACCCACCGTATCCACTGGGAATCTGCCAGCCTCCTGCG
ATCAGAAGAGACCAAGGAAAATGAGGGTTTCACAGTCACAGCTGAAGGAAAAGGCCAAGGCACCTTGTCGGTGGTGACAATGTACCATGC
TAAGGCCAAAGATCAACTCACCTGTAATAAATTCGACCTCAAGGTCACCATAAAACCAGCACCGGAAACAGAAAAGAGGCCTCAGGATGC
CAAGAACACTATGATCCTTGAGATCTGTACCAGGTACCGGGGAGACCAGGATGCCACTATGTCTATATTGGACATATCCATGATGACTGG
CTTTGCTCCAGACACAGATGACCTGAAGCAGCTGGCCAATGGTGTTGACAGATACATCTCCAAGTATGAGCTGGACAAAGCCTTCTCCGA
TAGGAACACCCTCATCATCTACCTGGACAAGGTCTCACACTCTGAGGATGACTGTCTAGCTTTCAAAGTTCACCAATACTTTAATGTAGA
GCTTATCCAGCCTGGAGCAGTCAAGGTCTACGCCTATTACAACCTGGAGGAAAGCTGTACCCGGTTCTACCATCCGGAAAAGGAGGATGG
AAAGCTGAACAAGCTCTGCCGTGATGAACTGTGCCGCTGTGCTGAGGAGAATTGCTTCATACAAAAGTCGGATGACAAGGTCACCCTGGA
AGAACGGCTGGACAAGGCCTGTGAGCCAGGAGTGGACTATGTGTACAAGACCCGACTGGTCAAGGTTCAGCTGTCCAATGACTTTGACGA
GTACATCATGGCCATTGAGCAGACCATCAAGTCAGGCTCGGATGAGGTGCAGGTTGGACAGCAGCGCACGTTCATCAGCCCCATCAAGTG
CAGAGAAGCCCTGAAGCTGGAGGAGAAGAAACACTACCTCATGTGGGGTCTCTCCTCCGATTTCTGGGGAGAGAAGCCCAACCTCAGCTA
CATCATCGGGAAGGACACTTGGGTGGAGCACTGGCCCGAGGAGGACGAATGCCAAGACGAAGAGAACCAGAAACAATGCCAGGACCTCGG
CGCCTTCACCGAGAGCATGGTTGTCTTTGGGTGCCCCAACTGACCACACCCCCATTCCCCCACTCCAGATAAAGCTTCAGTTATATCTCA
CGTGTCTGGAGTTCTTTGCCAAGAGGGAGAGGCTGAAATCCCCAGCCGCCTCACCTGCAGCTCAGCTCCATCCTACTTGAAACCTCACCT

>3973_3973_1_ALDOB-C3_ALDOB_chr9_104190751_ENST00000374855_C3_chr19_6713520_ENST00000245907_length(amino acids)=1380AA_BP=
MPESLKRIPIEDGSGEVVLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKTPKYFKPGMPFDLM
VFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRT
ELRPGETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWV
DVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAG
LTFTSSSGQQTAQRAELQCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEACKKVFLDCCNYITE
LRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEV
TVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEVK
AAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHL
IVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTAYVVKVFSLAVNLI
AIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNL
QRSYTVAIAGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATF
MVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDL
KVTIKPAPETEKRPQDAKNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDRNTLIIYLDKVSH
SEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDY
VYKTRLVKVQLSNDFDEYIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSYIIGKDTWVEHWPE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ALDOB-C3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	C3	chr9:104190751	chr19:6713520	ENST00000245907		6	41	1634_1659	257.6666666666667	1664.0	CFP/properdin

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ALDOB-C3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ALDOB-C3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ALDOB	C0016751	Hereditary fructose intolerance syndrome	14	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	ALDOB	C0003129	Anoxemia	1	CTD_human
Hgene	ALDOB	C0003130	Anoxia	1	CTD_human
Hgene	ALDOB	C0019193	Hepatitis, Toxic	1	CTD_human
Hgene	ALDOB	C0024623	Malignant neoplasm of stomach	1	CTD_human
Hgene	ALDOB	C0038356	Stomach Neoplasms	1	CTD_human
Hgene	ALDOB	C0241910	Autoimmune Chronic Hepatitis	1	CTD_human
Hgene	ALDOB	C0242184	Hypoxia	1	CTD_human
Hgene	ALDOB	C0700292	Hypoxemia	1	CTD_human
Hgene	ALDOB	C0860207	Drug-Induced Liver Disease	1	CTD_human
Hgene	ALDOB	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Hgene	ALDOB	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Hgene	ALDOB	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Hgene	ALDOB	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Hgene	ALDOB	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
Tgene		C3151071	COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE	5	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0242383	Age related macular degeneration	4	CTD_human;GENOMICS_ENGLAND
Tgene		C2752037	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 5	4	GENOMICS_ENGLAND;UNIPROT
Tgene		C1969651	Macular Degeneration, Age-Related, 9	2	CTD_human;UNIPROT
Tgene		C0003257	Antibody Deficiency Syndrome	1	CTD_human
Tgene		C0007787	Transient Ischemic Attack	1	CTD_human
Tgene		C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Tgene		C0013221	Drug toxicity	1	CTD_human
Tgene		C0017665	Membranous glomerulonephritis	1	CTD_human
Tgene		C0019061	Hemolytic-Uremic Syndrome	1	GENOMICS_ENGLAND
Tgene		C0019193	Hepatitis, Toxic	1	CTD_human
Tgene		C0021051	Immunologic Deficiency Syndromes	1	CTD_human
Tgene		C0021655	Insulin Resistance	1	CTD_human
Tgene		C0022660	Kidney Failure, Acute	1	CTD_human
Tgene		C0030524	Paratuberculosis	1	CTD_human
Tgene		C0030807	Pemphigus	1	CTD_human
Tgene		C0030809	Pemphigus Vulgaris	1	CTD_human
Tgene		C0034152	Henoch-Schoenlein Purpura	1	CTD_human
Tgene		C0041755	Adverse reaction to drug	1	CTD_human
Tgene		C0042386	Vasculitis, Hemorrhagic	1	CTD_human
Tgene		C0086445	Idiopathic Membranous Glomerulonephritis	1	CTD_human
Tgene		C0086922	Rheumatoid Purpura	1	CTD_human
Tgene		C0238281	Middle Cerebral Artery Syndrome	1	CTD_human
Tgene		C0242461	Purpura, Nonthrombocytopenic	1	CTD_human
Tgene		C0263313	Pemphigus Foliaceus	1	CTD_human
Tgene		C0272242	Complement deficiency disease	1	GENOMICS_ENGLAND
Tgene		C0376362	Purpura Hemorrhagica	1	CTD_human
Tgene		C0472381	Posterior Circulation Transient Ischemic Attack	1	CTD_human
Tgene		C0740376	Middle Cerebral Artery Thrombosis	1	CTD_human
Tgene		C0740391	Middle Cerebral Artery Occlusion	1	CTD_human
Tgene		C0740392	Infarction, Middle Cerebral Artery	1	CTD_human
Tgene		C0751019	Carotid Circulation Transient Ischemic Attack	1	CTD_human
Tgene		C0751020	Transient Ischemic Attack, Vertebrobasilar Circulation	1	CTD_human
Tgene		C0751021	Crescendo Transient Ischemic Attacks	1	CTD_human
Tgene		C0751022	Brain Stem Ischemia, Transient	1	CTD_human
Tgene		C0751845	Middle Cerebral Artery Embolus	1	CTD_human
Tgene		C0751846	Left Middle Cerebral Artery Infarction	1	CTD_human
Tgene		C0751847	Embolic Infarction, Middle Cerebral Artery	1	CTD_human
Tgene		C0751848	Thrombotic Infarction, Middle Cerebral Artery	1	CTD_human
Tgene		C0751849	Right Middle Cerebral Artery Infarction	1	CTD_human
Tgene		C0860207	Drug-Induced Liver Disease	1	CTD_human
Tgene		C0917805	Transient Cerebral Ischemia	1	CTD_human
Tgene		C0920563	Insulin Sensitivity	1	CTD_human
Tgene		C1262760	Hepatitis, Drug-Induced	1	CTD_human
Tgene		C1332655	Complement component 3 deficiency	1	GENOMICS_ENGLAND
Tgene		C1527335	Transient Ischemic Attack, Anterior Circulation	1	CTD_human
Tgene		C1565662	Acute Kidney Insufficiency	1	CTD_human
Tgene		C1704378	Heymann Nephritis	1	CTD_human
Tgene		C2609414	Acute kidney injury	1	CTD_human
Tgene		C2931788	Atypical Hemolytic Uremic Syndrome	1	CTD_human;GENOMICS_ENGLAND
Tgene		C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Tgene		C4087273	C3 glomerulopathy	1	GENOMICS_ENGLAND
Tgene		C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Tgene		C4279912	Chemically-Induced Liver Toxicity	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ALDOB-C3 (FusionGDB2 ID:HG229TG718)

Fusion Gene Summary for ALDOB-C3

Fusion Gene ORF analysis for ALDOB-C3

Fusion Genomic Features for ALDOB-C3

Fusion Protein Features for ALDOB-C3

Fusion Gene Sequence for ALDOB-C3

Fusion Gene PPI Analysis for ALDOB-C3

Related Drugs for ALDOB-C3

Related Diseases for ALDOB-C3

Fusion Gene Studies
in Kim Lab