Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ABCB7-SH3BGRL (FusionGDB2 ID:HG22TG6451)

Fusion Gene Summary for ABCB7-SH3BGRL

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCB7-SH3BGRL
Fusion gene ID: hg22tg6451
HgeneTgene
Gene symbol

ABCB7

SH3BGRL

Gene ID

22

6451

Gene nameATP binding cassette subfamily B member 7SH3 domain binding glutamate rich protein like
SynonymsABC7|ASAT|Atm1p|EST140535HEL-S-115|SH3BGR
Cytomap('ABCB7')('SH3BGRL')

Xq13.3

Xq21.1

Type of geneprotein-codingprotein-coding
DescriptionATP-binding cassette sub-family B member 7, mitochondrialABC transporter 7 proteinATP-binding cassette transporter 7ATP-binding cassette, sub-family B (MDR/TAP), member 7SH3 domain-binding glutamic acid-rich-like proteinSH3 domain binding glutamic acid-rich protein likeSH3-binding domain glutamic acid-rich protein likeepididymis secretory protein Li 115
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000253577, ENST00000339447, 
ENST00000373394, ENST00000534570, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 4 X 5=140
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCB7 [Title/Abstract] AND SH3BGRL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCB7(74375940)-SH3BGRL(80532483), # samples:1
Anticipated loss of major functional domain due to fusion event.ABCB7-SH3BGRL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCB7-SH3BGRL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCB7-SH3BGRL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCB7-SH3BGRL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ABCB7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SH3BGRL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8364-01AABCB7chrX

74375940

-SH3BGRLchrX

80532483

+


Top

Fusion Gene ORF analysis for ABCB7-SH3BGRL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000253577ENST00000481106ABCB7chrX

74375940

-SH3BGRLchrX

80532483

+
5CDS-3UTRENST00000339447ENST00000481106ABCB7chrX

74375940

-SH3BGRLchrX

80532483

+
5CDS-3UTRENST00000373394ENST00000481106ABCB7chrX

74375940

-SH3BGRLchrX

80532483

+
In-frameENST00000253577ENST00000373212ABCB7chrX

74375940

-SH3BGRLchrX

80532483

+
In-frameENST00000339447ENST00000373212ABCB7chrX

74375940

-SH3BGRLchrX

80532483

+
In-frameENST00000373394ENST00000373212ABCB7chrX

74375940

-SH3BGRLchrX

80532483

+
intron-3CDSENST00000534570ENST00000373212ABCB7chrX

74375940

-SH3BGRLchrX

80532483

+
intron-3UTRENST00000534570ENST00000481106ABCB7chrX

74375940

-SH3BGRLchrX

80532483

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000253577ABCB7chrX74375940-ENST00000373212SH3BGRLchrX80532483+181319325492155
ENST00000339447ABCB7chrX74375940-ENST00000373212SH3BGRLchrX80532483+17951757474155
ENST00000373394ABCB7chrX74375940-ENST00000373212SH3BGRLchrX80532483+17961768475155

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253577ENST00000373212ABCB7chrX74375940-SH3BGRLchrX80532483+0.0022957050.9977043
ENST00000339447ENST00000373212ABCB7chrX74375940-SH3BGRLchrX80532483+0.0032664390.99673355
ENST00000373394ENST00000373212ABCB7chrX74375940-SH3BGRLchrX80532483+0.0035676140.9964324

Top

Fusion Genomic Features for ABCB7-SH3BGRL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABCB7chrX74375939-SH3BGRLchrX80532482+3.79E-060.9999962
ABCB7chrX74375939-SH3BGRLchrX80532482+3.79E-060.9999962

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ABCB7-SH3BGRL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:74375940/chrX:80532483)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSH3BGRLchrX:74375940chrX:80532483ENST000003732120461_6715115.0MotifSH3-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCB7chrX:74375940chrX:80532483ENST00000253577-116140_43656754.0DomainABC transmembrane type-1
HgeneABCB7chrX:74375940chrX:80532483ENST00000253577-116472_70656754.0DomainABC transporter
HgeneABCB7chrX:74375940chrX:80532483ENST00000373394-116140_43656753.0DomainABC transmembrane type-1
HgeneABCB7chrX:74375940chrX:80532483ENST00000373394-116472_70656753.0DomainABC transporter
HgeneABCB7chrX:74375940chrX:80532483ENST00000253577-116505_51656754.0Nucleotide bindingATP
HgeneABCB7chrX:74375940chrX:80532483ENST00000373394-116505_51656753.0Nucleotide bindingATP
HgeneABCB7chrX:74375940chrX:80532483ENST00000253577-116141_16156754.0TransmembraneHelical
HgeneABCB7chrX:74375940chrX:80532483ENST00000253577-116186_20656754.0TransmembraneHelical
HgeneABCB7chrX:74375940chrX:80532483ENST00000253577-116260_28056754.0TransmembraneHelical
HgeneABCB7chrX:74375940chrX:80532483ENST00000253577-116291_31156754.0TransmembraneHelical
HgeneABCB7chrX:74375940chrX:80532483ENST00000253577-116383_40356754.0TransmembraneHelical
HgeneABCB7chrX:74375940chrX:80532483ENST00000253577-116410_43056754.0TransmembraneHelical
HgeneABCB7chrX:74375940chrX:80532483ENST00000373394-116141_16156753.0TransmembraneHelical
HgeneABCB7chrX:74375940chrX:80532483ENST00000373394-116186_20656753.0TransmembraneHelical
HgeneABCB7chrX:74375940chrX:80532483ENST00000373394-116260_28056753.0TransmembraneHelical
HgeneABCB7chrX:74375940chrX:80532483ENST00000373394-116291_31156753.0TransmembraneHelical
HgeneABCB7chrX:74375940chrX:80532483ENST00000373394-116383_40356753.0TransmembraneHelical
HgeneABCB7chrX:74375940chrX:80532483ENST00000373394-116410_43056753.0TransmembraneHelical


Top

Fusion Gene Sequence for ABCB7-SH3BGRL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>216_216_1_ABCB7-SH3BGRL_ABCB7_chrX_74375940_ENST00000253577_SH3BGRL_chrX_80532483_ENST00000373212_length(transcript)=1813nt_BP=193nt
CTCGGTTCCTCTTTCCTCGCTCAAGATGGCGCTGCTCGCGATGCATTCTTGGCGCTGGGCGGCCGCGGCGGCTGCTTTCGAAAAGCGCCG
GCACTCCGCGATTCTGATCCGGCCTTTAGTCTCTGTTAGCGGCTCAGGTCCGCAGTGGAGGCCACATCAACTCGGCGCCTTGGGAACCGC
TCGAGCCTACCAGATTAAGAAGAAACAACAAGATGTGCTTGGTTTCCTAGAAGCCAACAAAATAGGATTTGAAGAAAAAGATATTGCAGC
CAATGAAGAGAATCGGAAGTGGATGAGAGAAAATGTACCTGAAAATAGTCGACCAGCCACAGGTTACCCCCTGCCACCTCAGATTTTCAA
TGAAAGCCAGTATCGCGGGGACTATGATGCCTTCTTTGAAGCCAGAGAAAATAATGCAGTGTATGCCTTCTTAGGCTTGACAGCCCCACC
TGGTTCAAAGGAAGCAGAAGTGCAAGCAAAGCAGCAAGCATGAACCTTAAGCACTGTGCTTTAAGCATCCTGAAAAATGAGTCTCCATTG
CTTTTATAAAATAGCAGAATTAGCTTTGCTTCAAAAGAAATAGGCTTAATGTTGAAATAATAGATTAGTTGGGTTTTCACATGCAAACAT
TCAAAATGAATACAAAATTAAAATTTGAACATTATGGTGATTATGGTGAGGAGAATGGGATATTAACATAAAATTATATTAATAAGTAGA
TATCGTAGAAATAGTGTTGTTACCTGCCAAGCCATCCTGTATACACCAATGATTTTACAAAGAAAACACCCTTCCCTCCTTCTGCCATTA
CTATGGCAACTTAAGTGTATCTGCAGCTCTACATTAAAAAGGAGAAAGAGAAATAACCTGTCTCTCATTCCTAAGTTGCCTCATTAATTT
TCATGAACAAGAATATGTACCTTTTTGATGCTATATTACTGCGATTAAAAAGTTCTTGCAGGTAATGTTTATGATATGTTAAACGTTGTA
ATTTCCTATCGTAATTATAACATTCCCATTCTTTTGTAGATGAAACTTCTACATATTGAACCACAGATTTTCTGAGCTTCTAAATGTAGC
CTTTCATTGCACATTTCAGTGATCAGAATAGATATCCTTTTACACGCACAAAAGCAATAGATTCATTCAGTGGACAAGTTCCTTGTTTAA
CTACACAGCTATGATGGAATGATATATCCAAGTTCCTTGCCTCAGTGAAATATGCATATGTATATCATGAAAGTGGGATGCCAAGTAAGC
TTAAAATGGCATTCTCTAGCAAAGAGATTAGACTTTTAAATAACTCTTATAAAACAGGTTGGCGATCATTTCCCAAGATTGGTTTCCCTT
GAGTTTTTGCTAAAACAAATCTTAGTAGTTTTGCCCGTTTAAAACAACTCACAATCGTAAATGCTACTATTCCTAAGATATCTTACCTTT
TTATTTCAGTTTAGCCATGTATTGTATGAGTGTATTAGTCTAAGCAGTGAGAATCTTTTCTATGCCTCTATTCCAGCAAAAAGTAGAAGT
ATCAAATAAAAAGGGCAACTTTTAAAATATTAAGCCTGAAGACTTCTAAAAAGACAAGAAACATGGCCTAAATAACCAACATAGATTTAC
ATAGTAAGTTTCACACTACCTTATTACCAAAAGCAAACACCTCTTACTTTAAACTACATTATCATGTATATCTATTGTATGCTGGTCTTT
ACTTTTTGCCAAAATCAACATATAATGAAGAGATGCCTTTGTTTCATGAGATTCAAACTTGATGCTATGCTTTAAAATAAACTCAGTACT

>216_216_1_ABCB7-SH3BGRL_ABCB7_chrX_74375940_ENST00000253577_SH3BGRL_chrX_80532483_ENST00000373212_length(amino acids)=155AA_BP=56
MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWM

--------------------------------------------------------------
>216_216_2_ABCB7-SH3BGRL_ABCB7_chrX_74375940_ENST00000339447_SH3BGRL_chrX_80532483_ENST00000373212_length(transcript)=1795nt_BP=175nt
GCTCAAGATGGCGCTGCTCGCGATGCATTCTTGGCGCTGGGCGGCCGCGGCGGCTGCTTTCGAAAAGCGCCGGCACTCCGCGATTCTGAT
CCGGCCTTTAGTCTCTGTTAGCGGCTCAGGTCCGCAGTGGAGGCCACATCAACTCGGCGCCTTGGGAACCGCTCGAGCCTACCAGATTAA
GAAGAAACAACAAGATGTGCTTGGTTTCCTAGAAGCCAACAAAATAGGATTTGAAGAAAAAGATATTGCAGCCAATGAAGAGAATCGGAA
GTGGATGAGAGAAAATGTACCTGAAAATAGTCGACCAGCCACAGGTTACCCCCTGCCACCTCAGATTTTCAATGAAAGCCAGTATCGCGG
GGACTATGATGCCTTCTTTGAAGCCAGAGAAAATAATGCAGTGTATGCCTTCTTAGGCTTGACAGCCCCACCTGGTTCAAAGGAAGCAGA
AGTGCAAGCAAAGCAGCAAGCATGAACCTTAAGCACTGTGCTTTAAGCATCCTGAAAAATGAGTCTCCATTGCTTTTATAAAATAGCAGA
ATTAGCTTTGCTTCAAAAGAAATAGGCTTAATGTTGAAATAATAGATTAGTTGGGTTTTCACATGCAAACATTCAAAATGAATACAAAAT
TAAAATTTGAACATTATGGTGATTATGGTGAGGAGAATGGGATATTAACATAAAATTATATTAATAAGTAGATATCGTAGAAATAGTGTT
GTTACCTGCCAAGCCATCCTGTATACACCAATGATTTTACAAAGAAAACACCCTTCCCTCCTTCTGCCATTACTATGGCAACTTAAGTGT
ATCTGCAGCTCTACATTAAAAAGGAGAAAGAGAAATAACCTGTCTCTCATTCCTAAGTTGCCTCATTAATTTTCATGAACAAGAATATGT
ACCTTTTTGATGCTATATTACTGCGATTAAAAAGTTCTTGCAGGTAATGTTTATGATATGTTAAACGTTGTAATTTCCTATCGTAATTAT
AACATTCCCATTCTTTTGTAGATGAAACTTCTACATATTGAACCACAGATTTTCTGAGCTTCTAAATGTAGCCTTTCATTGCACATTTCA
GTGATCAGAATAGATATCCTTTTACACGCACAAAAGCAATAGATTCATTCAGTGGACAAGTTCCTTGTTTAACTACACAGCTATGATGGA
ATGATATATCCAAGTTCCTTGCCTCAGTGAAATATGCATATGTATATCATGAAAGTGGGATGCCAAGTAAGCTTAAAATGGCATTCTCTA
GCAAAGAGATTAGACTTTTAAATAACTCTTATAAAACAGGTTGGCGATCATTTCCCAAGATTGGTTTCCCTTGAGTTTTTGCTAAAACAA
ATCTTAGTAGTTTTGCCCGTTTAAAACAACTCACAATCGTAAATGCTACTATTCCTAAGATATCTTACCTTTTTATTTCAGTTTAGCCAT
GTATTGTATGAGTGTATTAGTCTAAGCAGTGAGAATCTTTTCTATGCCTCTATTCCAGCAAAAAGTAGAAGTATCAAATAAAAAGGGCAA
CTTTTAAAATATTAAGCCTGAAGACTTCTAAAAAGACAAGAAACATGGCCTAAATAACCAACATAGATTTACATAGTAAGTTTCACACTA
CCTTATTACCAAAAGCAAACACCTCTTACTTTAAACTACATTATCATGTATATCTATTGTATGCTGGTCTTTACTTTTTGCCAAAATCAA

>216_216_2_ABCB7-SH3BGRL_ABCB7_chrX_74375940_ENST00000339447_SH3BGRL_chrX_80532483_ENST00000373212_length(amino acids)=155AA_BP=56
MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWM

--------------------------------------------------------------
>216_216_3_ABCB7-SH3BGRL_ABCB7_chrX_74375940_ENST00000373394_SH3BGRL_chrX_80532483_ENST00000373212_length(transcript)=1796nt_BP=176nt
CGCTCAAGATGGCGCTGCTCGCGATGCATTCTTGGCGCTGGGCGGCCGCGGCGGCTGCTTTCGAAAAGCGCCGGCACTCCGCGATTCTGA
TCCGGCCTTTAGTCTCTGTTAGCGGCTCAGGTCCGCAGTGGAGGCCACATCAACTCGGCGCCTTGGGAACCGCTCGAGCCTACCAGATTA
AGAAGAAACAACAAGATGTGCTTGGTTTCCTAGAAGCCAACAAAATAGGATTTGAAGAAAAAGATATTGCAGCCAATGAAGAGAATCGGA
AGTGGATGAGAGAAAATGTACCTGAAAATAGTCGACCAGCCACAGGTTACCCCCTGCCACCTCAGATTTTCAATGAAAGCCAGTATCGCG
GGGACTATGATGCCTTCTTTGAAGCCAGAGAAAATAATGCAGTGTATGCCTTCTTAGGCTTGACAGCCCCACCTGGTTCAAAGGAAGCAG
AAGTGCAAGCAAAGCAGCAAGCATGAACCTTAAGCACTGTGCTTTAAGCATCCTGAAAAATGAGTCTCCATTGCTTTTATAAAATAGCAG
AATTAGCTTTGCTTCAAAAGAAATAGGCTTAATGTTGAAATAATAGATTAGTTGGGTTTTCACATGCAAACATTCAAAATGAATACAAAA
TTAAAATTTGAACATTATGGTGATTATGGTGAGGAGAATGGGATATTAACATAAAATTATATTAATAAGTAGATATCGTAGAAATAGTGT
TGTTACCTGCCAAGCCATCCTGTATACACCAATGATTTTACAAAGAAAACACCCTTCCCTCCTTCTGCCATTACTATGGCAACTTAAGTG
TATCTGCAGCTCTACATTAAAAAGGAGAAAGAGAAATAACCTGTCTCTCATTCCTAAGTTGCCTCATTAATTTTCATGAACAAGAATATG
TACCTTTTTGATGCTATATTACTGCGATTAAAAAGTTCTTGCAGGTAATGTTTATGATATGTTAAACGTTGTAATTTCCTATCGTAATTA
TAACATTCCCATTCTTTTGTAGATGAAACTTCTACATATTGAACCACAGATTTTCTGAGCTTCTAAATGTAGCCTTTCATTGCACATTTC
AGTGATCAGAATAGATATCCTTTTACACGCACAAAAGCAATAGATTCATTCAGTGGACAAGTTCCTTGTTTAACTACACAGCTATGATGG
AATGATATATCCAAGTTCCTTGCCTCAGTGAAATATGCATATGTATATCATGAAAGTGGGATGCCAAGTAAGCTTAAAATGGCATTCTCT
AGCAAAGAGATTAGACTTTTAAATAACTCTTATAAAACAGGTTGGCGATCATTTCCCAAGATTGGTTTCCCTTGAGTTTTTGCTAAAACA
AATCTTAGTAGTTTTGCCCGTTTAAAACAACTCACAATCGTAAATGCTACTATTCCTAAGATATCTTACCTTTTTATTTCAGTTTAGCCA
TGTATTGTATGAGTGTATTAGTCTAAGCAGTGAGAATCTTTTCTATGCCTCTATTCCAGCAAAAAGTAGAAGTATCAAATAAAAAGGGCA
ACTTTTAAAATATTAAGCCTGAAGACTTCTAAAAAGACAAGAAACATGGCCTAAATAACCAACATAGATTTACATAGTAAGTTTCACACT
ACCTTATTACCAAAAGCAAACACCTCTTACTTTAAACTACATTATCATGTATATCTATTGTATGCTGGTCTTTACTTTTTGCCAAAATCA

>216_216_3_ABCB7-SH3BGRL_ABCB7_chrX_74375940_ENST00000373394_SH3BGRL_chrX_80532483_ENST00000373212_length(amino acids)=155AA_BP=56
MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ABCB7-SH3BGRL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ABCB7-SH3BGRL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ABCB7-SH3BGRL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCB7C1845028ANEMIA, SIDEROBLASTIC, AND SPINOCEREBELLAR ATAXIA6CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneABCB7C0002896Sideroblastic anemia2CTD_human
HgeneABCB7C0004134Ataxia1CTD_human
HgeneABCB7C0240991Ataxia, Sensory1CTD_human
HgeneABCB7C0278161Ataxia, Motor1CTD_human
HgeneABCB7C0427190Ataxia, Truncal1CTD_human
HgeneABCB7C0520966Abnormal coordination1CTD_human
HgeneABCB7C0750937Ataxia, Appendicular1CTD_human
HgeneABCB7C0750940Tremor, Rubral1CTD_human