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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ERP44-PCSK5 (FusionGDB2 ID:HG23071TG5125)

Fusion Gene Summary for ERP44-PCSK5

Fusion gene summary

Fusion gene information	Fusion gene name: ERP44-PCSK5
	Fusion gene ID: hg23071tg5125
		Hgene	Tgene
	Gene symbol	ERP44	PCSK5
	Gene ID	23071	5125
	Gene name	endoplasmic reticulum protein 44	proprotein convertase subtilisin/kexin type 5
	Synonyms	PDIA10\|TXNDC4	PC5\|PC6\|PC6A\|SPC6
	Cytomap	('ERP44')('PCSK5') 9q31.1	9q21.13
	Type of gene	protein-coding	protein-coding
	Description	endoplasmic reticulum resident protein 44ER protein 44endoplasmic reticulum resident protein 44 kDaepididymis secretory sperm binding proteinprotein disulfide isomerase family A, member 10thioredoxin domain containing 4 (endoplasmic reticulum)thiore	proprotein convertase subtilisin/kexin type 5prohormone convertase 5proprotein convertase 6protease PC6subtilasesubtilisin/kexin-like protease PC5
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000262455,
Fusion gene scores	* DoF score	6 X 5 X 3=90	6 X 6 X 3=108
	# samples	7	6
	** MAII score	log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ERP44 [Title/Abstract] AND PCSK5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ERP44(102768788)-PCSK5(78784620), # samples:1
Anticipated loss of major functional domain due to fusion event.	ERP44-PCSK5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERP44-PCSK5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERP44-PCSK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERP44-PCSK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ERP44	GO:0006457	protein folding	11847130
Hgene	ERP44	GO:0006986	response to unfolded protein	11847130
Hgene	ERP44	GO:0009100	glycoprotein metabolic process	11847130
Hgene	ERP44	GO:0034976	response to endoplasmic reticulum stress	11847130
Tgene	PCSK5	GO:0006465	signal peptide processing	16912035
Tgene	PCSK5	GO:0016485	protein processing	8901832\|15606899
Tgene	PCSK5	GO:0016486	peptide hormone processing	8901832
Tgene	PCSK5	GO:0043043	peptide biosynthetic process	8901832

Fusion gene breakpoints across ERP44 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PCSK5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-5798-01A	ERP44	chr9	102768788	-	PCSK5	chr9	78784620	+

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Fusion Gene ORF analysis for ERP44-PCSK5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000262455	ENST00000376752	ERP44	chr9	102768788	-	PCSK5	chr9	78784620	+
In-frame	ENST00000262455	ENST00000376767	ERP44	chr9	102768788	-	PCSK5	chr9	78784620	+
In-frame	ENST00000262455	ENST00000545128	ERP44	chr9	102768788	-	PCSK5	chr9	78784620	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262455	ERP44	chr9	102768788	-	ENST00000545128	PCSK5	chr9	78784620	+	8597	1216	50	5179	1709
ENST00000262455	ERP44	chr9	102768788	-	ENST00000376767	PCSK5	chr9	78784620	+	1930	1216	50	1669	539
ENST00000262455	ERP44	chr9	102768788	-	ENST00000376752	PCSK5	chr9	78784620	+	4876	1216	50	2338	762

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262455	ENST00000545128	ERP44	chr9	102768788	-	PCSK5	chr9	78784620	+	0.00036565	0.9996344
ENST00000262455	ENST00000376767	ERP44	chr9	102768788	-	PCSK5	chr9	78784620	+	0.000180368	0.9998197
ENST00000262455	ENST00000376752	ERP44	chr9	102768788	-	PCSK5	chr9	78784620	+	0.000133298	0.9998667

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Fusion Genomic Features for ERP44-PCSK5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ERP44	chr9	102768787	-	PCSK5	chr9	78784619	+	0.000540337	0.9994597
ERP44	chr9	102768787	-	PCSK5	chr9	78784619	+	0.000540337	0.9994597

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ERP44-PCSK5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:102768788/chr9:78784620)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERP44

chr9:102768788

chr9:78784620

ENST00000262455

30_138

338

407.0

Domain

Thioredoxin

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1812_1853

539

914.0

Compositional bias

Note=Asp-rich

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1812_1853

539

1861.0

Compositional bias

Note=Asp-rich

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

869_913

539

914.0

Domain

Note=PLAC

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

869_913

539

1861.0

Domain

Note=PLAC

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1807_1826

539

914.0

Region

AC 1

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1838_1860

539

914.0

Region

AC 2

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

636_1727

539

914.0

Region

Note=CRM (Cys-rich motif)

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1807_1826

539

1861.0

Region

AC 1

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1838_1860

539

1861.0

Region

AC 2

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

636_1727

539

1861.0

Region

Note=CRM (Cys-rich motif)

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1032_1077

539

914.0

Repeat

Note=FU 9

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1079_1121

539

914.0

Repeat

Note=FU 10

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1125_1168

539

914.0

Repeat

Note=FU 11

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1177_1221

539

914.0

Repeat

Note=FU 12

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1225_1272

539

914.0

Repeat

Note=FU 13

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1274_1318

539

914.0

Repeat

Note=FU 14

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1320_1363

539

914.0

Repeat

Note=FU 15

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1365_1411

539

914.0

Repeat

Note=FU 16

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1415_1461

539

914.0

Repeat

Note=FU 17

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1465_1510

539

914.0

Repeat

Note=FU 18

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1514_1559

539

914.0

Repeat

Note=FU 19

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1563_1610

539

914.0

Repeat

Note=FU 20

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1614_1659

539

914.0

Repeat

Note=FU 21

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1665_1712

539

914.0

Repeat

Note=FU 22

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

630_680

539

914.0

Repeat

Note=FU 1

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

683_730

539

914.0

Repeat

Note=FU 2

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

734_777

539

914.0

Repeat

Note=FU 3

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

779_824

539

914.0

Repeat

Note=FU 4

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

832_879

539

914.0

Repeat

Note=FU 5

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

882_927

539

914.0

Repeat

Note=FU 6

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

929_979

539

914.0

Repeat

Note=FU 7

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

982_1028

539

914.0

Repeat

Note=FU 8

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1032_1077

539

1861.0

Repeat

Note=FU 9

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1079_1121

539

1861.0

Repeat

Note=FU 10

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1125_1168

539

1861.0

Repeat

Note=FU 11

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1177_1221

539

1861.0

Repeat

Note=FU 12

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1225_1272

539

1861.0

Repeat

Note=FU 13

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1274_1318

539

1861.0

Repeat

Note=FU 14

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1320_1363

539

1861.0

Repeat

Note=FU 15

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1365_1411

539

1861.0

Repeat

Note=FU 16

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1415_1461

539

1861.0

Repeat

Note=FU 17

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1465_1510

539

1861.0

Repeat

Note=FU 18

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1514_1559

539

1861.0

Repeat

Note=FU 19

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1563_1610

539

1861.0

Repeat

Note=FU 20

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1614_1659

539

1861.0

Repeat

Note=FU 21

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1665_1712

539

1861.0

Repeat

Note=FU 22

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

630_680

539

1861.0

Repeat

Note=FU 1

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

683_730

539

1861.0

Repeat

Note=FU 2

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

734_777

539

1861.0

Repeat

Note=FU 3

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

779_824

539

1861.0

Repeat

Note=FU 4

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

832_879

539

1861.0

Repeat

Note=FU 5

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

882_927

539

1861.0

Repeat

Note=FU 6

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

929_979

539

1861.0

Repeat

Note=FU 7

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

982_1028

539

1861.0

Repeat

Note=FU 8

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1765_1860

539

914.0

Topological domain

Cytoplasmic

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1765_1860

539

1861.0

Topological domain

Cytoplasmic

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

1744_1764

539

914.0

Transmembrane

Helical

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

1744_1764

539

1861.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERP44

chr9:102768788

chr9:78784620

ENST00000262455

403_406

338

407.0

Motif

Prevents secretion from ER

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

134_453

539

914.0

Domain

Peptidase S8

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

461_601

539

914.0

Domain

P/Homo B

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

134_453

539

1861.0

Domain

Peptidase S8

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

461_601

539

1861.0

Domain

P/Homo B

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

519_521

539

914.0

Motif

Cell attachment site

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

519_521

539

1861.0

Motif

Cell attachment site

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000376752

115_1743

539

914.0

Topological domain

Extracellular

Tgene

PCSK5

chr9:102768788

chr9:78784620

ENST00000545128

115_1743

539

1861.0

Topological domain

Extracellular

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Fusion Gene Sequence for ERP44-PCSK5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>27483_27483_1_ERP44-PCSK5_ERP44_chr9_102768788_ENST00000262455_PCSK5_chr9_78784620_ENST00000376752_length(transcript)=4876nt_BP=1216nt
GAAGTGAGGGTGTGAGAGGCCTCTCTGGAAGTTGTCCCGGGTGTTCGCCGCTGGAGCCCGGGTCGAGAGGACGAGGTGCCGCTGCCTGGA
GAATCCTCCGCTGCCGTCGGCTCCCGGAGCCCAGCCCTTTCCTAACCCAACCCAACCTAGCCCAGTCCCAGCCGCCAGCGCCTGTCCCTG
TCACGGACCCCAGCGTTACCATGCATCCTGCCGTCTTCCTATCCTTACCCGACCTCAGATGCTCCCTTCTGCTCCTGGTAACTTGGGTTT
TTACTCCTGTAACAACTGAAATAACAAGTCTTGATACAGAGAATATAGATGAAATTTTAAACAATGCTGATGTTGCTTTAGTAAATTTTT
ATGCTGACTGGTGTCGTTTCAGTCAGATGTTGCATCCAATTTTTGAGGAAGCTTCCGATGTCATTAAGGAAGAATTTCCAAATGAAAATC
AAGTAGTGTTTGCCAGAGTTGATTGTGATCAGCACTCTGACATAGCCCAGAGATACAGGATAAGCAAATACCCAACCCTCAAATTGTTTC
GTAATGGGATGATGATGAAGAGAGAATACAGGGGTCAGCGATCAGTGAAAGCATTGGCAGATTACATCAGGCAACAAAAAAGTGACCCCA
TTCAAGAAATTCGGGACTTAGCAGAAATCACCACTCTTGATCGCAGCAAAAGAAATATCATTGGATATTTTGAGCAAAAGGACTCGGACA
ACTATAGAGTTTTTGAACGAGTAGCGAATATTTTGCATGATGACTGTGCCTTTCTTTCTGCATTTGGGGATGTTTCAAAACCGGAAAGAT
ATAGTGGCGACAACATAATCTACAAACCACCAGGGCATTCTGCTCCGGATATGGTGTACTTGGGAGCTATGACAAATTTTGATGTGACTT
ACAATTGGATTCAAGATAAATGTGTTCCTCTTGTCCGAGAAATAACATTTGAAAATGGAGAGGAATTGACAGAAGAAGGACTGCCTTTTC
TCATACTCTTTCACATGAAAGAAGATACAGAAAGTTTAGAAATATTCCAGAATGAAGTAGCTCGGCAATTAATAAGTGAAAAAGGTACAA
TAAACTTTTTACATGCCGATTGTGACAAATTTAGACATCCTCTTCTGCACATACAGAAAACTCCAGCAGATTGTCCTGTAATCGCTATTG
ACAGCTTTAGGCATATGTATGTGTTTGGAGACTTCAAAGATGTATTGCTATTTGATCACTCCATGGAAGGATTCAAAAACTGGGAGTTCA
TGACCATTCATTGCTGGGGAGAAAGAGCTGCTGGTGACTGGGTCCTTGAAGTTTATGATACTCCCTCTCAGCTAAGGAACTTTAAGACTC
CAGGTAAATTGAAAGAATGGTCTTTGGTCCTCTACGGCACCTCCGTGCAGCCATATTCACCAACCAATGAATTTCCGAAAGTGGAACGGT
TCCGCTATAGCCGAGTTGAAGACCCCACAGACGACTATGGCACAGAGGATTATGCAGGTCCCTGCGACCCTGAGTGCAGTGAGGTTGGCT
GTGACGGGCCAGGACCAGACCACTGCAATGACTGTTTGCACTACTACTACAAGCTGAAAAACAATACCAGGATCTGTGTCTCCAGCTGCC
CCCCTGGCCACTACCACGCCGACAAGAAGCGCTGCAGGAAGTGTGCCCCCAACTGTGAGTCCTGCTTTGGGAGCCATGGTGACCAATGCA
TGTCCTGCAAATATGGATACTTTCTGAATGAAGAAACCAACAGCTGTGTTACTCACTGCCCTGATGGGTCATATCAGGATACCAAGAAAA
ATCTTTGCCGGAAATGCAGTGAAAACTGCAAGACATGTACTGAATTCCATAACTGTACAGAATGTAGGGATGGGTTAAGCCTGCAGGGAT
CCCGGTGCTCTGTCTCCTGTGAAGATGGACGGTATTTCAACGGCCAGGACTGCCAGCCCTGCCACCGCTTCTGCGCCACTTGTGCTGGGG
CAGGAGCTGATGGGTGCATTAACTGCACAGAGGGCTACTTCATGGAGGATGGGAGATGCGTGCAGAGCTGTAGTATCAGCTATTACTTTG
ACCACTCTTCAGAGAATGGATACAAATCCTGCAAAAAATGTGATATCAGTTGTTTGACGTGCAATGGCCCAGGATTCAAGAACTGTACAA
GCTGCCCTAGTGGGTATCTCTTAGACTTAGGAATGTGTCAAATGGGAGCCATTTGCAAGGATGCAACGGAAGAGTCCTGGGCGGAAGGAG
GCTTCTGTATGCTTGTGAAAAAGAACAATCTGTGCCAACGGAAGGTTCTTCAACAACTTTGCTGCAAAACATGTACATTTCAAGGCTGAG
CAGCCATCTTAGATTTCTTTGTTCCTGTAGACTTATAGATTATTCCATATTATTAAAAAGAAAAAAGCCAAAAAGAAAAAAAAAAAAAGC
AAGCCACCTCTCTCTTTCTTTTCTTGCTCTCTTTTTCTTTCTCTCTCTCTCAAGTTTGTGCAGGGAGATGGTGAACTGTTTTGTCAGAAC
TTAAATGGAAAAAAAAATAAAACTACAACAAGCCTACCTTTTATAACTGGGTGTTTAGTGCTAAACAGCCAGAACCACAGAGACAGTATT
GTATGACCAAAGCATTTGATGCCAAAATTTGACGTTAAAGTAATGATTTGATTTCCTGCCCTGGTTTTGAAGGTCCATTTTTTTCCCTTT
TGCATTGACTTGCTTGTTTCCCCTTTGAAACACCTAAAAATACCTTTCCAAAACATCGCGAGAGCATACATAGACAAAAATGAAATAGAA
AGCTCTTGCATGCTTGAGTCCACCATTGGGGGAAATGACAGAAAACTGGACCTGAGGGCATTAGGAACATCCTACAGAGTTGTGTTTAGT
GTCGTTTGCCATGGTATTTCACAGTGAAACATGGATACTCTCCACACATCATTTACTTCATGCTGTGTACTTATGTACTGGTTTTTGCAT
TTTACTCACTTGATAAGTCTGCTCCACTGGTTTCATCAGATAGACTTGCTGCTACTGGCTTTTCCATTGTAGATTGGGTTATTTTACACG
CAGTTCGCCAAATGGGATTGCTCTGTATAGTCAAATTGGTGATGGACAGATGGACAGAATGCAGAGGTACATAGATGAGCTGAGGCTGAT
CCAGCTCCCCTGAAATTCAGAGTGTTAACTTTGTAGACCCTGCACAATCTCTTGGTGCTATCTAGCCATTACCCCCATTTTTTTTTTAAA
GGCCATCTGAAATTCCATTTGTCATGGTGGGAAGCATTTTGGATATGATGCAGGAAATCTCTTCCTGGAGTCAAAAGTTCCCAAGAGGTC
CTGTATTTTTAAGAAATGGAATTTATTTAAATAATATTTAAGCTTGTGCCCATGTTGGCCGGGCAACTTTTTTCAATGGTGCTTATTAGA
AGAAGTTTTTTCATCTTGTCATTTTAAGAAAATAAAACTGGAAATTGAATATGGGTGGCATGATTGTACCCTTTTAGTTCTCTTATTTTT
CTACTCCTCTGTCCCTCTATAACTATGCCATACTATTATATGCTGGTCCACTGAATGCTGAGATGATCTGTTTTTTGGGGTTTTTTTTTT
TTAAGAAATATTTTCACTGGTTTTCTGTGACTCTCTAAACACTTCATCGAAACTAGAAGACTGAATTATGAGGAAACTATTTGGATTAGT
GGCCAGAAACGATGAAATCTTATAGATCTTTTGACAGTTTCTCTGTTTAGGGGAGCCTAGACTGATATCAAGTTTCTTCATATCAAAGCT
TCATTGGTGACCTCATTTGCTTTACAAGTGACCAGCCATCTTGCAGGCTTCATGCTTCTGAGAGCCTTACTTAGAAGATGCTGCTGGAGT
CACAGCTGAGGAGAGGAATACTATCAACATGGACTATCCTGGGAAAGAGCTAGGAAGTAGATGCTGAGGTCCCCATCCAAACAGCAAGCT
AGGAAAAAGCCTGCCTTGAAAATATTTCTAGACATCAAAGATAACTTACAACCCAAAGTGAATAATAAGTAAATAGTCTGATGACCCTCT
TAATAGCATTGCAATTGTATTGAATCACATAATGATTCATAAGTAACTAGGGAACCAACTGATTTTGCTAAGCAGTCTTCCCCTTATAAC
ACCACAGGCCCTTCTGACACACAAAAAAATGAAAGTTAATCCTGGGTACAGCATACAGTTTTACATTTAAACGCACAGTCTTACGTGGAC
AAATGCAAGCACAAGCCTAAAGCAAGGTCAAGCAGATGGCAAAACCGAATTTGCCTGCAAAGAAATCTATTTAACTGAATCAGCCCATAA
TATTTGAGGCACGAGGTTACTGTGATTGATAGGAAAGATAAAAATGATGTCTGTTTTTGTAGACGAATAACCATCAACATGACAACAAAA
TTCATTGGGGTCTACCAGCGTGCATTCCATTTCCCACTGACCATGCAGGTGCACGTCGCGGAAATACTGGTTTAACTACTAGTGTGTTAC
TGCCTCATTTATCTACATAACATTATTAACTAGAACATAATGCTTTCAAAGTTTAAGTTAATGTTATATATTATGTATAAATATATATAT
TCATAATGAGATATATGTAATGGATAGTACAAAGTTTGGAGACTCAACAAATGCTCTAACCTTCTAGAGACAAAAGTCCTATTTCTGTTT
TCTTTTGTCTTTTTATTTTCAATTAGTGACCCATTGTTAAATCCAAATCCACTTTTACTGAAAAATACTGTACATGTGTAAAATGTTCAG
TTGTTTTTTTGTAAAATATAGTAGAACGGTTGTAACTGATACTGGCCAAAATCAATGTTATTCCATATTTTATTTTTTCTATTAAATTAA
CCTAAGTTCCTGTTTA

>27483_27483_1_ERP44-PCSK5_ERP44_chr9_102768788_ENST00000262455_PCSK5_chr9_78784620_ENST00000376752_length(amino acids)=762AA_BP=389
MEPGSRGRGAAAWRILRCRRLPEPSPFLTQPNLAQSQPPAPVPVTDPSVTMHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENID
EILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVK
ALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPD
MVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLH
IQKTPADCPVIAIDSFRHMYVFGDFKDVLLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQ
PYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAP
NCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQD
CQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGA
ICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTCTFQG

--------------------------------------------------------------
>27483_27483_2_ERP44-PCSK5_ERP44_chr9_102768788_ENST00000262455_PCSK5_chr9_78784620_ENST00000376767_length(transcript)=1930nt_BP=1216nt
GAAGTGAGGGTGTGAGAGGCCTCTCTGGAAGTTGTCCCGGGTGTTCGCCGCTGGAGCCCGGGTCGAGAGGACGAGGTGCCGCTGCCTGGA
GAATCCTCCGCTGCCGTCGGCTCCCGGAGCCCAGCCCTTTCCTAACCCAACCCAACCTAGCCCAGTCCCAGCCGCCAGCGCCTGTCCCTG
TCACGGACCCCAGCGTTACCATGCATCCTGCCGTCTTCCTATCCTTACCCGACCTCAGATGCTCCCTTCTGCTCCTGGTAACTTGGGTTT
TTACTCCTGTAACAACTGAAATAACAAGTCTTGATACAGAGAATATAGATGAAATTTTAAACAATGCTGATGTTGCTTTAGTAAATTTTT
ATGCTGACTGGTGTCGTTTCAGTCAGATGTTGCATCCAATTTTTGAGGAAGCTTCCGATGTCATTAAGGAAGAATTTCCAAATGAAAATC
AAGTAGTGTTTGCCAGAGTTGATTGTGATCAGCACTCTGACATAGCCCAGAGATACAGGATAAGCAAATACCCAACCCTCAAATTGTTTC
GTAATGGGATGATGATGAAGAGAGAATACAGGGGTCAGCGATCAGTGAAAGCATTGGCAGATTACATCAGGCAACAAAAAAGTGACCCCA
TTCAAGAAATTCGGGACTTAGCAGAAATCACCACTCTTGATCGCAGCAAAAGAAATATCATTGGATATTTTGAGCAAAAGGACTCGGACA
ACTATAGAGTTTTTGAACGAGTAGCGAATATTTTGCATGATGACTGTGCCTTTCTTTCTGCATTTGGGGATGTTTCAAAACCGGAAAGAT
ATAGTGGCGACAACATAATCTACAAACCACCAGGGCATTCTGCTCCGGATATGGTGTACTTGGGAGCTATGACAAATTTTGATGTGACTT
ACAATTGGATTCAAGATAAATGTGTTCCTCTTGTCCGAGAAATAACATTTGAAAATGGAGAGGAATTGACAGAAGAAGGACTGCCTTTTC
TCATACTCTTTCACATGAAAGAAGATACAGAAAGTTTAGAAATATTCCAGAATGAAGTAGCTCGGCAATTAATAAGTGAAAAAGGTACAA
TAAACTTTTTACATGCCGATTGTGACAAATTTAGACATCCTCTTCTGCACATACAGAAAACTCCAGCAGATTGTCCTGTAATCGCTATTG
ACAGCTTTAGGCATATGTATGTGTTTGGAGACTTCAAAGATGTATTGCTATTTGATCACTCCATGGAAGGATTCAAAAACTGGGAGTTCA
TGACCATTCATTGCTGGGGAGAAAGAGCTGCTGGTGACTGGGTCCTTGAAGTTTATGATACTCCCTCTCAGCTAAGGAACTTTAAGACTC
CAGGTAAATTGAAAGAATGGTCTTTGGTCCTCTACGGCACCTCCGTGCAGCCATATTCACCAACCAATGAATTTCCGAAAGTGGAACGGT
TCCGCTATAGCCGAGTTGAAGACCCCACAGACGACTATGGCACAGAGGATTATGCAGGTGAGCTGGCTTCCAGTGGGACACAGGCTAAAA
AGAGGCAGCTCATGCATCATCCCACCACATGGGAGAACAGAATGGAATGGAATGGAATGAAATGGAATGGAATGAAATGGAATGGAATGG
AATGGAATGGAATGGAATGGAATCGAATCGAATCGAATCGAATAGAATAGAATAGAATAGAACAGAACAGAATAGAATAGAACAGAACAA
TCTACTACCCATATTCTGACATATTTTCTTCCCCTTAAATATTTGTGTGTGTATATCAGTGCACTCATATATTCAAATATCCATATGTGT
TATCTGCAAAGCTAATAGTCCATATTGCGATTGTACCATAATATAGTTAATCTGTAATCTGGGACATATTGTTCGCTTACAGAATTTTAC
ACTATTTTAAACACGGTTTGGATAAACATCATTATTTATC

>27483_27483_2_ERP44-PCSK5_ERP44_chr9_102768788_ENST00000262455_PCSK5_chr9_78784620_ENST00000376767_length(amino acids)=539AA_BP=389
MEPGSRGRGAAAWRILRCRRLPEPSPFLTQPNLAQSQPPAPVPVTDPSVTMHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENID
EILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVK
ALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPD
MVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLH
IQKTPADCPVIAIDSFRHMYVFGDFKDVLLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQ
PYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGELASSGTQAKKRQLMHHPTTWENRMEWNGMKWNGMKWNGMEWNGMEWNRIESNRIE

--------------------------------------------------------------
>27483_27483_3_ERP44-PCSK5_ERP44_chr9_102768788_ENST00000262455_PCSK5_chr9_78784620_ENST00000545128_length(transcript)=8597nt_BP=1216nt
GAAGTGAGGGTGTGAGAGGCCTCTCTGGAAGTTGTCCCGGGTGTTCGCCGCTGGAGCCCGGGTCGAGAGGACGAGGTGCCGCTGCCTGGA
GAATCCTCCGCTGCCGTCGGCTCCCGGAGCCCAGCCCTTTCCTAACCCAACCCAACCTAGCCCAGTCCCAGCCGCCAGCGCCTGTCCCTG
TCACGGACCCCAGCGTTACCATGCATCCTGCCGTCTTCCTATCCTTACCCGACCTCAGATGCTCCCTTCTGCTCCTGGTAACTTGGGTTT
TTACTCCTGTAACAACTGAAATAACAAGTCTTGATACAGAGAATATAGATGAAATTTTAAACAATGCTGATGTTGCTTTAGTAAATTTTT
ATGCTGACTGGTGTCGTTTCAGTCAGATGTTGCATCCAATTTTTGAGGAAGCTTCCGATGTCATTAAGGAAGAATTTCCAAATGAAAATC
AAGTAGTGTTTGCCAGAGTTGATTGTGATCAGCACTCTGACATAGCCCAGAGATACAGGATAAGCAAATACCCAACCCTCAAATTGTTTC
GTAATGGGATGATGATGAAGAGAGAATACAGGGGTCAGCGATCAGTGAAAGCATTGGCAGATTACATCAGGCAACAAAAAAGTGACCCCA
TTCAAGAAATTCGGGACTTAGCAGAAATCACCACTCTTGATCGCAGCAAAAGAAATATCATTGGATATTTTGAGCAAAAGGACTCGGACA
ACTATAGAGTTTTTGAACGAGTAGCGAATATTTTGCATGATGACTGTGCCTTTCTTTCTGCATTTGGGGATGTTTCAAAACCGGAAAGAT
ATAGTGGCGACAACATAATCTACAAACCACCAGGGCATTCTGCTCCGGATATGGTGTACTTGGGAGCTATGACAAATTTTGATGTGACTT
ACAATTGGATTCAAGATAAATGTGTTCCTCTTGTCCGAGAAATAACATTTGAAAATGGAGAGGAATTGACAGAAGAAGGACTGCCTTTTC
TCATACTCTTTCACATGAAAGAAGATACAGAAAGTTTAGAAATATTCCAGAATGAAGTAGCTCGGCAATTAATAAGTGAAAAAGGTACAA
TAAACTTTTTACATGCCGATTGTGACAAATTTAGACATCCTCTTCTGCACATACAGAAAACTCCAGCAGATTGTCCTGTAATCGCTATTG
ACAGCTTTAGGCATATGTATGTGTTTGGAGACTTCAAAGATGTATTGCTATTTGATCACTCCATGGAAGGATTCAAAAACTGGGAGTTCA
TGACCATTCATTGCTGGGGAGAAAGAGCTGCTGGTGACTGGGTCCTTGAAGTTTATGATACTCCCTCTCAGCTAAGGAACTTTAAGACTC
CAGGTAAATTGAAAGAATGGTCTTTGGTCCTCTACGGCACCTCCGTGCAGCCATATTCACCAACCAATGAATTTCCGAAAGTGGAACGGT
TCCGCTATAGCCGAGTTGAAGACCCCACAGACGACTATGGCACAGAGGATTATGCAGGTCCCTGCGACCCTGAGTGCAGTGAGGTTGGCT
GTGACGGGCCAGGACCAGACCACTGCAATGACTGTTTGCACTACTACTACAAGCTGAAAAACAATACCAGGATCTGTGTCTCCAGCTGCC
CCCCTGGCCACTACCACGCCGACAAGAAGCGCTGCAGGAAGTGTGCCCCCAACTGTGAGTCCTGCTTTGGGAGCCATGGTGACCAATGCA
TGTCCTGCAAATATGGATACTTTCTGAATGAAGAAACCAACAGCTGTGTTACTCACTGCCCTGATGGGTCATATCAGGATACCAAGAAAA
ATCTTTGCCGGAAATGCAGTGAAAACTGCAAGACATGTACTGAATTCCATAACTGTACAGAATGTAGGGATGGGTTAAGCCTGCAGGGAT
CCCGGTGCTCTGTCTCCTGTGAAGATGGACGGTATTTCAACGGCCAGGACTGCCAGCCCTGCCACCGCTTCTGCGCCACTTGTGCTGGGG
CAGGAGCTGATGGGTGCATTAACTGCACAGAGGGCTACTTCATGGAGGATGGGAGATGCGTGCAGAGCTGTAGTATCAGCTATTACTTTG
ACCACTCTTCAGAGAATGGATACAAATCCTGCAAAAAATGTGATATCAGTTGTTTGACGTGCAATGGCCCAGGATTCAAGAACTGTACAA
GCTGCCCTAGTGGGTATCTCTTAGACTTAGGAATGTGTCAAATGGGAGCCATTTGCAAGGATGGAGAATATGTTGATGAGCATGGCCACT
GCCAGACCTGTGAGGCCTCATGTGCCAAGTGCCAGGGACCAACCCAGGAAGACTGCACTACCTGCCCCATGACAAGGATTTTTGATGATG
GCCGCTGTGTTTCGAACTGCCCCTCATGGAAATTTGAATTTGAGAACCAATGCCATCCATGCCACCACACCTGCCAGAGATGCCAAGGAA
GTGGCCCTACCCACTGCACCTCCTGTGGAGCAGACAACTATGGCCGAGAGCACTTCCTGTACCAGGGAGAGTGTGGAGATAGCTGCCCAG
AGGGCCACTATGCCACTGAGGGGAACACCTGCCTGCCCTGCCCAGACAACTGTGAGCTTTGCCACAGCGTGCATGTCTGCACAAGATGCA
TGAAGGGCTACTTCATAGCGCCCACCAACCACACATGCCAGAAGTTAGAGTGTGGACAAGGTGAAGTCCAAGACCCAGACTATGAAGAAT
GTGTCCCTTGTGAAGAAGGATGTCTGGGATGCAGCTTGGATGATCCAGGAACATGTACATCTTGCGCTATGGGGTATTACAGGTTTGATC
ACCATTGTTATAAAACCTGTCCTGAGAAGACCTACAGTGAGGAAGTGGAATGCAAGGCGTGTGATAGTAACTGTGGCAGCTGTGACCAGA
ATGGGTGTTACTGGTGTGAAGAGGGCTTCTTTCTCTTAGGTGGCAGTTGTGTGAGGAAATGTGGTCCTGGATTCTATGGTGACCAAGAAA
TGGGAGAATGTGAGTCCTGCCACCGAGCATGCGAAACCTGCACAGGCCCTGGTCATGACGAGTGCAGCAGCTGCCAGGAAGGACTGCAGC
TGCTGCGTGGGATGTGCGTGCATGCCACCAAGACCCAGGAGGAGGGCAAATTCTGGAATGATATTTTGAGAAAACTCCAGCCTTGTCATT
CTTCTTGTAAAACCTGCAATGGATCTGCAACTCTGTGCACTTCATGTCCCAAAGGTGCATATCTTCTGGCTCAGGCCTGTGTTTCCTCCT
GTCCCCAAGGCACATGGCCTTCCGTAAGGAGTGGGAGCTGCGAGAACTGTACGGAGGCCTGTGCCATCTGCTCTGGAGCCGATCTTTGCA
AAAAATGCCAGATGCAGCCGGGCCACCCTCTCTTCCTCCATGAAGGCAGGTGCTACTCCAAGTGCCCGGAGGGCTCTTATGCAGAAGACG
GCATATGTGAACGCTGTAGCTCTCCTTGCAGAACATGTGAAGGAAACGCCACCAACTGCCATTCTTGTGAAGGAGGCCACGTCCTGCACC
ACGGAGTGTGCCAGGAAAACTGCCCCGAGAGGCACGTGGCTGTGAAGGGGGTATGCAAGCATTGCCCAGAGATGTGTCAGGACTGCATCC
ATGAGAAAACATGCAAAGAGTGCACGCCTGAGTTCTTCCTGCACGATGATATGTGCCACCAGTCCTGTCCCCGTGGCTTCTATGCAGACT
CGCGCCACTGTGTCCCCTGCCATAAAGACTGTCTGGAGTGCAGTGGCCCCAAAGCCGACGACTGCGAGCTCTGTCTTGAGAGTTCCTGGG
TCCTCTATGATGGACTGTGCTTGGAGGAGTGTCCAGCAGGAACCTATTATGAAAAGGAGACTAAGGAGTGCAGAGATTGCCACAAGTCCT
GCTTGACCTGCTCATCATCTGGGACCTGCACCACCTGTCAGAAAGGCCTGATCATGAACCCTCGTGGGAGCTGCATGGCCAACGAGAAGT
GCTCACCCTCCGAGTACTGGGATGAGGATGCTCCCGGGTGCAAGCCCTGCCATGTTAAGTGCTTCCACTGCATGGGGCCGGCGGAGGACC
AGTGTCAAACATGCCCCATGAACAGCCTTCTTCTCAACACAACCTGTGTGAAGGACTGCCCAGAGGGCTATTATGCCGATGAGGACAGCA
ACCGGTGTGCCCACTGCCACAGCTCTTGCAGGACATGTGAAGGGAGACACAGCAGGCAGTGCCACTCCTGCCGACCGGGCTGGTTCCAGC
TAGGAAAAGAGTGCCTGCTCCAGTGCAGGGAAGGATATTACGCAGACAACTCCACTGGCCGGTGTGAGAGGTGCAACAGGAGCTGCAAGG
GGTGCCAGGGCCCACGGCCCACAGACTGCCTGTCTTGCGATAGATTTTTCTTTCTGCTCCGCTCCAAAGGAGAGTGTCATCGCTCCTGCC
CAGACCATTACTATGTAGAGCAAAGCACACAGACCTGTGAGAGATGCCATCCGACTTGTGATCAATGCAAAGGAAAAGGAGCGTTGAATT
GTTTATCCTGTGTGTGGAGTTACCACCTCATGGGAGGGATCTGCACCTCGGACTGTCTTGTGGGGGAATACAGAGTGGGAGAGGGAGAGA
AGTTTAACTGTGAAAAATGCCACGAGAGCTGCATGGAATGCAAGGGACCAGGGGCCAAGAACTGCACCTTGTGCCCTGCCAACCTGGTGC
TGCACATGGACGACAGCCACTGCCTCCACTGCTGCAACACCTCTGATCCCCCCAGTGCCCAGGAGTGCTGTGACTGCCAGGACACCACGG
ACGAATGCATCCTTCGAACAAGCAAGGTTAGGCCTGCAACTGAGCATTTCAAGACAGCTCTGTTCATCACCTCCTCCATGATGCTGGTGC
TTCTGCTCGGGGCAGCTGTGGTAGTGTGGAAGAAATCTCGTGGCCGAGTCCAGCCAGCAGCAAAGGCCGGCTATGAAAAACTGGCCGACC
CCAACAAGTCTTACTCCTCCTATAAGAGCAGCTATAGAGAGAGCACCAGCTTTGAAGAGGATCAGGTGATTGAGTACAGGGATCGGGACT
ATGATGAGGATGATGATGATGACATCGTCTACATGGGCCAGGATGGCACAGTCTACCGGAAATTTAAATATGGGCTGCTGGATGACGATG
ACATAGATGAGCTGGAATATGATGACGAGAGTTACTCCTACTACCAGTAAACAGGCACTCCCCCACCAACACCACCATTCCACTCTCAGG
CATGCCTGTGAGCATCACTGTTTTTGGTTTTATCCCCACACCAGGCTGATGTGTGAGTTTTTCTATTTGTCTTCTTTAACCATGAGTCCA
ACCAGAATATGTAAGAATGATGAAATACTTTGTTCTTCTTTTGAGTGGCTAAACTCAATTAACAGTTCCTGTTCAACCGTAATTGAAGAG
CAAGGATAAAATTCAGAGGCATTTTCCTCAAAATAATGTGTTAAGACACAAAAATGAAGGAAGTGAAAACAAATGAGATTTGTACAAACT
CTTCTATGTGATTTTAAAAAAAGGACAGCAGATCTATAGAAATTCTGTTTCCGAGCTGCATTGTGGAGGTGTCTGCTGCCTCCTGGTATT
CTAATTTTTCTTTATCTAATTTTGGGGATAATGGAGGTACAAAGGAGTTGTTGGTTTGGTGGTGTTTTTCTTCCCTTTAGCTGTCTTTAG
GCAGAAATTTGTTTTGTAAGGGCCAAGAAAAGAGGGCTCTTATCAATTGACTCCAGGCCACCCCTGGTGAGCAGAAGAGACCACCTGGGC
TGGGCTGCTCAGGACCTACTTGAGATAAGGGAAGAAAAGAGAAGGTGCATCATAGCTGAGGAGCCATGAGGTCACCCCAGGCCCTAGTTC
CTCCGCAGGAATCCAGAGTCACAACAATTCTAAAGGCAGAGCAAGCCCAGCGAGAAAGAAATAACTGAATTTCCAGGAACTGCACTCTCA
TGATTTTCTGGGTACTTTTCGCCTGGGAGACATCAGCTAAGACATCGAATAATAAAAGAAAAATGGCAGTGTTAACCTAACATAAAATGG
AATAAAATGACAAACACTTCATCCGCTCTAAAAAATTCAGAGCTTTCCTTCATCAACAACCCATCACAAAACCGTGGACTCTCAATAGAA
AGAGTTGGAATAGAGTCTAACATGGAAAAAAAAAAATCCCAATATGCTGCTCACAAGCTGTACTCTAGCTGCTGACCAGCCTTCCAGCAC
TGCTCATCACTATGATTTTTGTTTCTAGACTTCCTAGGCTTCCTTTTTTCCATTCTTCTGTCAAGTGTATTCTTGGATTCATGCAACTGA
GGACAGTTTTTGTCCAGATTGTAACACAGAGAAGGGCTCTTGCTATGCAAAATGATGTTGGCAGGGTCTTACAGATTTCCTTGTCAAAAT
AGACCTTACAGGCAGTACTAGAAATGGAGCACCAGAAAGCAAAAATGACATTTTCAGAGAATGATGATAATTATAATCTATTGCACACCT
ACTACCAGATAACAAGCTAAGTAATTCCCCCCCAAAAATGCCCCACTTATCCATTTTGGTACTTACCATACTCCCATGAGGTTGGTATTG
CTATTATTCTGTTCTTGTAGGAAACCTGAGGCTTACAAGAGGTTAGGTAACTAGTCCAAGGTCATGCAAAGCTCAACAAAATTCAAGAAA
AAAGAATGATCACCCTAAAGCGTGTGTTCTTATAACTATGCTACTGAAATAAGGTGGGAAAATAAGCATCCTAAATATAATTAAAGTCAT
GCCTATTGTTTTAGTCTATAATATCAATGTTATCTTTACTAAATTCATGGATTTTCTTTTTTTAACATAATGTATCACTGACACAGAAAA
TCTTTATGAAGAAGTCTTCAGTTTACTAAAGGCTTGTGCTTCTTTAGAGGAAAGCTCTTAAAACAGGGTTGACAAACAGTCTCTGGAAAG
AGCCAGCTAGTAAGTACATTAGGCTTTCTTGGCCAGAAAGTCTCTGTCATAACCACTCAGCTCTGCTATTATAGCATGAATGCAGCTGGT
ACATAACGGATGGGTGAGCTGTGCTTCAATAAAACCTTATTTATGGACACTGACATTTGAAATTCAGGTAATTTTCACATATTATAAAAT
TTTATTCTTCTTTTGATTTTTTTCAACCTTTTAAAATTTAAAAATGCAAAAGCTATTCTCAGTTCACAGCATTACAAGAACAGGTGGTGG
GTCAGATTTGGCCAACAGGCTGTACTTTGCTGACTTTATCTTTAAAACAGTTTTCAGAGATCATACATGTACATGTATGATATGCCTCCA
AAAATTTTGATCATTTAAAATTATCTCCTTGGCCAGGCGTGGTGGCTCATACCTCTAATCCTAGCACTTTGGGAGACTGAGGCAGGCAGA
TCACCTGAAGTCAGGAGTTTGATACCAGCTTAGCCAACATGGTGAAACCCCATTTCTACTAAAAATACAATAAAAATCTGGGCATGTTGG
TGCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGCAAATCACTTGAGCCCGGGAGGCAGAGGTTGCAGTGAGCGGAGATGGCA
CCATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAATAAGTAACTAACTAACTAACTAAATAAATAAATAAATAAAAT
TATCTCCTTGCCAGGACTGCTGGCTCATGCCTGTAATCCCAGCACTCTGGGAGGCTAAGGCAGGAGGATTGCTGACCCACCACCTGTTCT
TGAGCCCAGGAGTTCGACATCAGCCTTGGACAACATAGTGAGACTCCCGTGTCTACAAAAAATTTAAAAATTAGCCAGGCATGGTGGCAA
GTGTCTGTAGTCTCAGCTACTCAGGAGGCTAAGGTGGAAGGATCACTTGAACCCGGGAGGTCGAGGCTGCAGTGAGCTGTGATCTTGCTA
TTGCACTTCAGCCTGAATGACAGAGCTAAGACCCTGACTCAAAATAAATAAATAACATTATCTCTTCAAAATGTATCTGAAGCCCTGATA
GTTCTACTTTCAATTCTTAGAAACATATAAAAATATATGCATGATAGCCATCATATCAATGGAAGACTTTCTCACCTCTGTGGTTGCAGT
TAGCTTACAAAAACGAGCAATTTTGCTTATACTGTGTTGTTCATCTTCCTTGTTAATTCTAAAGCTCTGATAGACTGAGTTTGACATTTC
TTTCTGTAAACTGGAAATTGTTTTCTATGAAAAAAAAACTCTATGATACACAGTTAAAGATTGGTTGAGGTTGAGATGAACTTCAATACT
AAGAAAAATTGTGGTGTTCCTCTGTGTGGCCTGCAATGAAAAGAAGGCTCATGCTTGTGTATTGAGGTTTGACATCTTTCCTTCTTTGTT
TTTAGTCATGCAACGTCATTCTTAGATGGCTTTTGAATACTATGCTAATGACTATCTAAATAGATAAATATGTGATTGGAAAACAAAGTC
ACCTTTTAGTTTTCTACTTGGAAATATTAAGAGAATCCTTGTAGACTGGAAACACACCAAAAGGCTGGGTAAAGCATGGGAGGTTCCAGT
TAATAGAAAGTAATTTTAAAATTGGAAATAAAATTAAATCAAGACCA

>27483_27483_3_ERP44-PCSK5_ERP44_chr9_102768788_ENST00000262455_PCSK5_chr9_78784620_ENST00000545128_length(amino acids)=1709AA_BP=389
MEPGSRGRGAAAWRILRCRRLPEPSPFLTQPNLAQSQPPAPVPVTDPSVTMHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENID
EILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVK
ALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPD
MVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLH
IQKTPADCPVIAIDSFRHMYVFGDFKDVLLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQ
PYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAP
NCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQD
CQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGA
ICKDGEYVDEHGHCQTCEASCAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTSCGADNYGRE
HFLYQGECGDSCPEGHYATEGNTCLPCPDNCELCHSVHVCTRCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPG
TCTSCAMGYYRFDHHCYKTCPEKTYSEEVECKACDSNCGSCDQNGCYWCEEGFFLLGGSCVRKCGPGFYGDQEMGECESCHRACETCTGP
GHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENC
TEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVKG
VCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYY
EKETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCV
KDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFF
FLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGP
GAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECCDCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRV
QPAAKAGYEKLADPNKSYSSYKSSYRESTSFEEDQVIEYRDRDYDEDDDDDIVYMGQDGTVYRKFKYGLLDDDDIDELEYDDESYSYYQ

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Fusion Gene PPI Analysis for ERP44-PCSK5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	ERP44	chr9:102768788	chr9:78784620	ENST00000262455	-	10	12	236_285	338.6666666666667	407.0	ITPR1

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ERP44-PCSK5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ERP44-PCSK5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ERP44	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	ERP44	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene		C0003466	Anus, Imperforate	1	CTD_human
Tgene		C0005941	Bone Diseases, Developmental	1	CTD_human
Tgene		C0018816	Heart Septal Defects	1	CTD_human
Tgene		C0018818	Ventricular Septal Defects	1	CTD_human
Tgene		C0022360	Jaw Abnormalities	1	CTD_human
Tgene		C0022658	Kidney Diseases	1	CTD_human
Tgene		C0024115	Lung diseases	1	CTD_human
Tgene		C0026633	Mouth Abnormalities	1	CTD_human
Tgene		C0040588	Tracheoesophageal Fistula	1	CTD_human
Tgene		C0220708	VATER Association	1	CTD_human
Tgene		C0344490	Sacral agenesis	1	CTD_human
Tgene		C0431415	Lumbosacral agenesis	1	CTD_human
Tgene		C0431943	Lower Extremity Deformities, Congenital	1	CTD_human
Tgene		C0795690	Congenital omphalocele	1	CTD_human
Tgene		C1306503	Congenital exomphalos	1	CTD_human
Tgene		C1531773	Currarino triad	1	CTD_human
Tgene		C1838568	Sacral defect and anterior sacral meningocele	1	CTD_human
Tgene		C1838569	Caudal Dysgenesis Syndrome	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ERP44-PCSK5 (FusionGDB2 ID:HG23071TG5125)

Fusion Gene Summary for ERP44-PCSK5

Fusion Gene ORF analysis for ERP44-PCSK5

Fusion Genomic Features for ERP44-PCSK5

Fusion Protein Features for ERP44-PCSK5

Fusion Gene Sequence for ERP44-PCSK5

Fusion Gene PPI Analysis for ERP44-PCSK5

Related Drugs for ERP44-PCSK5

Related Diseases for ERP44-PCSK5

Fusion Gene Studies
in Kim Lab