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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MYCBP2-PIBF1 (FusionGDB2 ID:HG23077TG10464)

Fusion Gene Summary for MYCBP2-PIBF1

Fusion gene summary

Fusion gene information	Fusion gene name: MYCBP2-PIBF1
	Fusion gene ID: hg23077tg10464
		Hgene	Tgene
	Gene symbol	MYCBP2	PIBF1
	Gene ID	23077	10464
	Gene name	MYC binding protein 2	progesterone immunomodulatory binding factor 1
	Synonyms	Myc-bp2\|PAM\|PHR1\|Phr	C13orf24\|CEP90\|JBTS33\|PIBF
	Cytomap	('MYCBP2')('PIBF1') 13q22.3	13q21.33-q22.1
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase MYCBP2HighwireMYC binding protein 2, E3 ubiquitin protein ligasePAM/Highwire/RPM-1 protein 1RING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Myc	progesterone-induced-blocking factor 1centrosomal protein of 90 kDa
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000357337, ENST00000407578, ENST00000544440, ENST00000360084, ENST00000482517,
Fusion gene scores	* DoF score	14 X 16 X 8=1792	16 X 13 X 13=2704
	# samples	15	23
	** MAII score	log2(15/1792*10)=-3.57853623156172 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/2704*10)=-3.55538938533781 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MYCBP2 [Title/Abstract] AND PIBF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MYCBP2(77730193)-PIBF1(73547729), # samples:2
Anticipated loss of major functional domain due to fusion event.	MYCBP2-PIBF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MYCBP2-PIBF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MYCBP2-PIBF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MYCBP2-PIBF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MYCBP2-PIBF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MYCBP2	GO:0016567	protein ubiquitination	29643511
Hgene	MYCBP2	GO:0031398	positive regulation of protein ubiquitination	20534529
Tgene	PIBF1	GO:0031393	negative regulation of prostaglandin biosynthetic process	3863495
Tgene	PIBF1	GO:0032695	negative regulation of interleukin-12 production	14634107
Tgene	PIBF1	GO:0032733	positive regulation of interleukin-10 production	14634107
Tgene	PIBF1	GO:0032815	negative regulation of natural killer cell activation	12516630
Tgene	PIBF1	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	16393965
Tgene	PIBF1	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	16393965
Tgene	PIBF1	GO:0042976	activation of Janus kinase activity	16393965

Fusion gene breakpoints across MYCBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PIBF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-QH-A6X9-01A	MYCBP2	chr13	77730193	-	PIBF1	chr13	73547729	+
ChimerDB4	LGG	TCGA-QH-A6X9-01A	MYCBP2	chr13	77730193	-	PIBF1	chr13	73572960	+
ChimerDB4	LGG	TCGA-QH-A6X9	MYCBP2	chr13	77730193	-	PIBF1	chr13	73547729	+

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Fusion Gene ORF analysis for MYCBP2-PIBF1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000357337	ENST00000489922	MYCBP2	chr13	77730193	-	PIBF1	chr13	73547729	+
5CDS-3UTR	ENST00000357337	ENST00000489922	MYCBP2	chr13	77730193	-	PIBF1	chr13	73572960	+
5CDS-3UTR	ENST00000407578	ENST00000489922	MYCBP2	chr13	77730193	-	PIBF1	chr13	73547729	+
5CDS-3UTR	ENST00000407578	ENST00000489922	MYCBP2	chr13	77730193	-	PIBF1	chr13	73572960	+
5CDS-3UTR	ENST00000544440	ENST00000489922	MYCBP2	chr13	77730193	-	PIBF1	chr13	73547729	+
5CDS-3UTR	ENST00000544440	ENST00000489922	MYCBP2	chr13	77730193	-	PIBF1	chr13	73572960	+
5UTR-3CDS	ENST00000360084	ENST00000326291	MYCBP2	chr13	77730193	-	PIBF1	chr13	73547729	+
5UTR-3CDS	ENST00000360084	ENST00000326291	MYCBP2	chr13	77730193	-	PIBF1	chr13	73572960	+
5UTR-3UTR	ENST00000360084	ENST00000489922	MYCBP2	chr13	77730193	-	PIBF1	chr13	73547729	+
5UTR-3UTR	ENST00000360084	ENST00000489922	MYCBP2	chr13	77730193	-	PIBF1	chr13	73572960	+
Frame-shift	ENST00000357337	ENST00000326291	MYCBP2	chr13	77730193	-	PIBF1	chr13	73547729	+
Frame-shift	ENST00000357337	ENST00000326291	MYCBP2	chr13	77730193	-	PIBF1	chr13	73572960	+
Frame-shift	ENST00000407578	ENST00000326291	MYCBP2	chr13	77730193	-	PIBF1	chr13	73547729	+
Frame-shift	ENST00000544440	ENST00000326291	MYCBP2	chr13	77730193	-	PIBF1	chr13	73547729	+
In-frame	ENST00000407578	ENST00000326291	MYCBP2	chr13	77730193	-	PIBF1	chr13	73572960	+
In-frame	ENST00000544440	ENST00000326291	MYCBP2	chr13	77730193	-	PIBF1	chr13	73572960	+
intron-3CDS	ENST00000482517	ENST00000326291	MYCBP2	chr13	77730193	-	PIBF1	chr13	73547729	+
intron-3CDS	ENST00000482517	ENST00000326291	MYCBP2	chr13	77730193	-	PIBF1	chr13	73572960	+
intron-3UTR	ENST00000482517	ENST00000489922	MYCBP2	chr13	77730193	-	PIBF1	chr13	73547729	+
intron-3UTR	ENST00000482517	ENST00000489922	MYCBP2	chr13	77730193	-	PIBF1	chr13	73572960	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000544440

MYCBP2

chr13

77730193

ENST00000326291

PIBF1

chr13

73572960

7578

6819

7043

2343

ENST00000407578

MYCBP2

chr13

77730193

ENST00000326291

PIBF1

chr13

73572960

7941

7182

183

7406

2407

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000544440	ENST00000326291	MYCBP2	chr13	77730193	-	PIBF1	chr13	73572960	+	0.000253249	0.99974674
ENST00000407578	ENST00000326291	MYCBP2	chr13	77730193	-	PIBF1	chr13	73572960	+	0.000358892	0.99964106

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Fusion Genomic Features for MYCBP2-PIBF1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYCBP2-PIBF1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:77730193/chr13:73547729)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

103_126

2267

4641.0

Compositional bias

Lys-rich

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

766_814

2267

4641.0

Compositional bias

Cys-rich

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

103_126

2267

4641.0

Compositional bias

Lys-rich

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

766_814

2267

4641.0

Compositional bias

Cys-rich

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

1235_1386

2267

4641.0

Region

PHR domain 1

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

1726_1884

2267

4641.0

Region

PHR domain 2

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

1235_1386

2267

4641.0

Region

PHR domain 1

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

1726_1884

2267

4641.0

Region

PHR domain 2

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

1010_1066

2267

4641.0

Repeat

RCC1 5

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

600_655

2267

4641.0

Repeat

RCC1 1

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

699_755

2267

4641.0

Repeat

RCC1 2

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

907_957

2267

4641.0

Repeat

RCC1 3

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

958_1008

2267

4641.0

Repeat

RCC1 4

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

1010_1066

2267

4641.0

Repeat

RCC1 5

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

600_655

2267

4641.0

Repeat

RCC1 1

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

699_755

2267

4641.0

Repeat

RCC1 2

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

907_957

2267

4641.0

Repeat

RCC1 3

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

958_1008

2267

4641.0

Repeat

RCC1 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

2720_2844

2267

4641.0

Compositional bias

Ser-rich

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

3194_3215

2267

4641.0

Compositional bias

Lys-rich

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

3262_3293

2267

4641.0

Compositional bias

Note=Gly-rich

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

2720_2844

2267

4641.0

Compositional bias

Ser-rich

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

3194_3215

2267

4641.0

Compositional bias

Lys-rich

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

3262_3293

2267

4641.0

Compositional bias

Note=Gly-rich

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

3719_3897

2267

4641.0

Domain

DOC

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

3719_3897

2267

4641.0

Domain

DOC

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

2022_2550

2267

4641.0

Region

RAE1 binding

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

4539_4676

2267

4641.0

Region

Tandem cysteine domain

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

2022_2550

2267

4641.0

Region

RAE1 binding

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

4539_4676

2267

4641.0

Region

Tandem cysteine domain

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

2341_2443

2267

4641.0

Repeat

Filamin

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

2341_2443

2267

4641.0

Repeat

Filamin

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000357337

4428_4479

2267

4641.0

Zinc finger

RING-type%3B atypical

Hgene

MYCBP2

chr13:77730193

chr13:73572960

ENST00000544440

4428_4479

2267

4641.0

Zinc finger

RING-type%3B atypical

Tgene

PIBF1

chr13:77730193

chr13:73572960

ENST00000326291

1_184

683

758.0

Region

Sufficient for NK inhibitory function

Tgene

PIBF1

chr13:77730193

chr13:73572960

ENST00000326291

1_419

683

758.0

Region

Mediates modulation of Th2 dominant cytokine production

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Fusion Gene Sequence for MYCBP2-PIBF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>56206_56206_1_MYCBP2-PIBF1_MYCBP2_chr13_77730193_ENST00000407578_PIBF1_chr13_73572960_ENST00000326291_length(transcript)=7941nt_BP=7182nt
CGGCGGCAGTGGCGGCACCGCCTCCTCCTCACATTCCCGGGGTGGCGGGGTTAGATGAGCGGCCCCAGTAGCGGCGAGGGCGGCGCGGGG
GGGAGGAGGAGAAGAAGGAGGAGGAGAAGGAGGTCGCTGTCTTTGTAGTCTCCCTGCTGCGGGAGCCAGAGGCCGCCGCCGGAGCCGTCG
TCGTTGGAAAAGGGCTGTGTGTGCGCGCGCGTGTCTGCCCGCCCGGCCCGCGGGGACGAGGCGGCGGCGGCGGCGGCGGCGGCGAGGATG
ATGATGTGCGCAGCGACTGCCTCCCCCGCCGCCGCCTCCTCGGGGCTCGGCGGGGACGGATTCTACCCAGCCGCCACCTTCTCTTCCTCC
CCGGCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGG
GGTCACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGG
GGCGGCAGCGCTGGACACCCAGCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAAGTG
AAGACAAGAAGCAAGTCTGAAAACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATTTAC
TGTAATGTACGCCATTGCGTTCTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAATCA
GATAGTGATGAAGAAGAGGAATCCAAAGAGCCCCCTATCAAGCTTCCAAAGATTATTGAGGTTGGCCTTTGTGAAGTTTTTGAATTGATC
AAAGAGACACGATTTTCTCATCCATCCCTGTGTCTCAGGAGTCTCCAAGCCCTGCTCAACGTGCTGCAGGGCCAGCAGCCAGAAGGCCTC
CAGTCTGAGCCACCTGAGGTCCTAGAGTCTCTCTTCCAGCTTCTTTTGGAAATCACCGTTCGAAGTACTGGGATGAATGACAGCACAGGA
CAGTCCTTAACAGCACTTTCCTGTGCTTGCCTCTTTAGTCTGGTGGCTTCTTGGGGAGAAACAGGAAGGACACTTCAGGCCATCTCTGCT
ATCCTCACCAACAATGGAAGCCATGCTTGCCAAACTATTCAGGTGCCAACAATTCTAAATTCGCTACAGAGAAGTGTACAAGCAGTTTTG
GTGGGAAAAATTCAAATTCAGGACTGGTTTAGTAATGGCATTAAGAAAGCAGCTTTAATGCACAAGTGGCCATTAAAAGAAATATCTGTT
GATGAAGATGACCAATGTCTACTTCAGAATGATGGATTTTTTCTTTATCTATTATGCAAGGATGGATTATATAAAATAGGCTCTGGATAC
AGTGGAACAGTTAGGGGCCATATATACAATTCTACATCCCGTATTAGAAACAGAAAAGAAAAAAAGTCTTGGTTAGGGTATGCTCAGGGT
TATTTATTATATAGAGATGTGAATAACCACAGCATGACAGCCATAAGGATAAGCCCTGAAACACTGGAGCAAGATGGTACTGTGATGTTA
CCAGATTGCCACACTGAAGGTCAAAATATTTTATTCACTGATGGAGAATATATTAATCAGATAGCTGCTTCAAGAGATGATGGCTTTGTT
GTCAGAATATTTGCCACAAGCACTGAACCTGTTCTACAGCAAGAATTGCAACTTAAACTGGCTAGAAAATGCTTACATGCCTGTGGTATC
TCACTATTCGATCTGGAAAAGGACTTGCATATTATAAGTACAGGATTTGATGAGGAGTCAGCAATTCTTGGTGCAGGACGAGAGTTTGCG
CTAATGAAAACAGCAAATGGAAAGATATATTACACTGGCAAATACCAGAGTCTTGGAATCAAACAAGGTGGTCCTTCAGCAGGAAAATGG
GTTGAGCTACCAATTACAAAATCTCCAAAGATAGTACACTTCTCAGTTGGACACGATGGCTCTCACGCCCTTTTAGTTGCAGAAGATGGG
AGCATATTCTTTACAGGATCTGCTAGTAAAGGAGAAGATGGAGAATCAACTAAGAGCAGACGGCAATCCAAACCTTATAAACCTAAAAAG
ATAATTAAGATGGAAGGAAAGATTGTGGTATATACAGCCTGCAATAATGGAAGTAGTTCTGTTATTTCTAAAGATGGAGAACTCTACATG
TTTGGAAAAGATGCCATTTACTCTGATAGTTCAAGTTTGGTAACTGATTTGAAGGGCCATTTTGTAACTCAGGTAGCTATGGGCAAAGCT
CACACTTGTGTTTTAATGAAGAATGGAGAGGTGTGGACATTTGGTGTAAATAATAAAGGACAGTGTGGACGAGATACTGGTGCCATGAAC
CAAGGTGGGAAAGGGTTTGGAGTTGAAAATATGGCAACAGCAATGGATGAAGACCTGGAAGAAGAACTAGATGAAAAAGATGAGAAGTCT
ATGATGTGCCCTCCAGGCATGCACAAATGGAAGCTGGAGCAGTGCATGGTTTGCACTGTCTGTGGAGACTGTACAGGTTATGGAGCCAGC
TGTGTCAGTAGTGGACGGCCAGACAGAGTCCCCGGAGGGATCTGTGGTTGTGGTTCCGGAGAATCTGGTTGTGCTGTGTGTGGATGTTGC
AAGGCCTGTGCAAGAGAGTTAGATGGTCAAGAGGCAAGACAAAGAGGAATTCTTGATGCAGTGAAAGAAATGATACCTTTAGATCTTCTT
TTAGCTGTCCCAGTGCCCGGGGTTAACATTGAAGAACACCTTCAGTTACGACAAGAAGAAAAACGGCAACGTGTAATCAGAAGGCACAGA
TTAGAGGAAGGAAGAGGCCCCCTTGTATTTGCTGGTCCTATTTTTATGAACCATCGAGAACAGGCTCTAGCCAGACTCAGATCCCATCCA
GCACAGCTAAAGCATAAACGGGACAAGCACAAAGATGGAAGTGGAGAAAGAGGCGAAAAGGATGCAAGCAAAATCACAACATACCCTCCA
GGCTCTGTGCGATTTGACTGTGAGCTCCGGGCAGTCCAAGTCAGCTGTGGATTTCACCATTCAGTGGTTTTAATGGAAAATGGAGATGTC
TATACATTTGGTTATGGGCAGCATGGGCAGCTAGGACATGGAGATGTCAACTCCAGGGGATGTCCCACTCTTGTTCAAGCATTGCCAGGC
CCTAGCACACAAGTCACTGCAGGCAGCAACCATACGGCAGTACTTTTAATGGATGGACAGGTCTTCACATTTGGAAGTTTTTCTAAAGGA
CAACTGGGCAGACCAATTTTGGATGTGCCATATTGGAATGCAAAGCCAGCTCCCATGCCTAACATTGGATCAAAATATGGAAGAAAAGCT
ACTTGGATAGGTGCAAGTGGGGACCAAACTTTTTTACGAATTGATGAAGCACTTATTAATTCTCATGTACTTGCTACATCAGAAATTTTT
GCCAGTAAACACATAATAGGCTTGGTACCTGCTTCTATATCAGAACCTCCTCCATTTAAATGCCTTCTGATAAATAAAGTGGATGGGAGT
TGTAAAACTTTTAATGACTCAGAACAAGAGGATCTGCAAGGATTTGGTGTGTGTCTTGATCCTGTATATGATGTAATTTGGAGGTTTCGA
CCAAATACTAGAGAGCTGTGGTGTTACAATGCGGTGGTTGCTGATGCCAGGCTTCCCTCTGCAGCAGACATGCAGTCCAGATGTAGTATC
CTAAGTCCTGAACTTGCCTTACCAACAGGATCAAGGGCCCTCACTACCCGATCTCATGCAGCTTTGCACATTTTAGGTTGTCTTGATACC
TTGGCAGCTATGCAGGACTTAAAAATGGGTGTTGCAAGTACAGAGGAAGAGACTCAAGCAGTAATGAAGGTTTATTCTAAAGAAGATTAT
AGTGTGGTAAACAGGTTTGAAAGTCATGGAGGAGGCTGGGGTTATTCTGCCCATTCAGTAGAAGCTATACGTTTCAGTGCCGACACTGAT
ATTTTACTTGGTGGTCTTGGTCTGTTTGGAGGTAGAGGAGAATATACTGCTAAAATTAAGCTGTTTGAATTGGGTCCTGATGGAGGAGAT
CATGAAACTGATGGTGACCTTCTTGCAGAGACTGATGTATTGGCTTATGACTGTGCTGCTAGAGAAAAATATGCAATGATGTTTGATGAG
CCTGTTCTCCTGCAAGCTGGGTGGTGGTATGTGGCATGGGCCCGAGTGTCAGGACCCAGCAGTGACTGTGGATCTCATGGACAGGCATCT
ATTACCACAGATGATGGGGTTGTTTTCCAGTTCAAGAGTTCAAAGAAATCAAATAATGGTACAGATGTTAATGCGGGTCAGATACCTCAG
TTATTATACAGACTTCCAACCAGTGATGGCAGTGCTTCAAAAGGCAAACAGCAAACCAGTGAACCTGTACACATTTTAAAGAGGTCTTTT
GCAAGAACTGTCTCAGTGGAATGTTTTGAGTCATTGTTGAGTATTCTTCACTGGAGCTGGACCACCTTAGTCTTAGGAGTTGAAGAACTT
AGAGGATTAAAAGGATTCCAGTTCACAGCTACACTCCTAGATTTAGAGAGACTGCGCTTTGTGGGTACCTGTTGTCTGAGGTTATTGCGT
GTCTATACCTGTGAAATTTACCCAGTGTCAGCTACAGGAAAAGCAGTTGTAGAAGAAACTAGCAAATTAGCAGAGTGTATTGGAAAAACC
AGAACTTTGTTAAGAAAAATTTTATCAGAAGGAGTTGATCACTGCATGGTGAAATTGGATAATGATCCTCAAGGATATCTCAGTCAACCC
TTGAGTCTTCTAGAAGCTGTCCTTCAGGAATGTCATAATACTTTCACTGCCTGCTTTCATTCTTTCTACCCAACTCCTGCCTTACAGTGG
GCTTGCCTTTGTGATCTGCTGAATTGTTTGGATCAGGATATCCAAGAAGCAAACTTCAAGACATCAAGTAGCCGACTCCTTGCAGCTGTT
ATGTCAGCTCTGTGTCACACGTCTGTTAAGCTGACTTCCATCTTCCCGATTGCGTATGATGGAGAAGTATTACTACGATCAATTGTTAAA
CAAGTTAGTACAGAGAACGACTCAACACTAGTTCATCGTTTTCCCCTTTTGGTGGCACATATGGAAAAACTCAGCCAGAGTGAAGAGAAT
ATCTCAGGGATGACAAGCTTCCGTGAAGTTCTGGAGAAAATGCTGGTCATTGTTGTGCTACCAGTCAGGAACAGCCTGAGGAGAGAAAAT
GAACTCTTCTCCTCCCACCTCGTCTCTAACACCTGTGGATTACTGGCCAGCATTGTCAGTGAACTGACAGCGTCAGCCCTGGGATCTGAG
GTTGATGGACTTAATTCTCTTCACTCTGTAAAAGCTAGTGCTAACCGATTTACAAAAACAAGTCAGGGCAGAAGTTGGAACACTGGGAAC
GGGTCCCCTGATGCAATCTGTTTTTCAGTAGACAAACCTGGAATAGTTGTGGTTGGTTTCTCTGTCTATGGAGGAGGTGGAATTCATGAA
TATGAATTAGAGGTGTTGGTTGATGATAGTGAACATGCAGGAGATTCAACTCATTCCCACAGATGGACATCTCTGGAATTAGTGAAAGGA
ACGTACACAACGGATGACTCACCCAGTGATATAGCTGAGATCAGACTTGACAAAGTGGTTCCTTTAAAGGAAAATGTTAAATATGCTGTG
CGCTTGAGGAACTATGGAAGCCGTACAGCCAATGGAGATGGAGGAATGACCACAGTTCAGTGCCCTGATGGTGTGACATTCACATTCAGC
ACGTGCAGCTTGAGCAGTAACGGCACAAACCAAACCAGAGGACAGATCCCACAGATACTCTACTATAGGAGTGAATTTGATGGAGATTTA
CAATCCCAACTTCTGAGTAAAGCCAATGAAGAAGATAAAAACTGTAGCAGAGCATTGTCTGTTGTAAGCACTGTCGTTCGAGCCTCTAAG
GACCTCCTGCACAGAGCTCTTGCTGTGGATGCTGATGACATTCCAGAACTGCTGAGTTCTTCCAGTCTGTTTTCCATGCTGCTCCCCCTT
ATTATAGCCTACATAGGACCAGTAGCTGCTGCTATTCCCAAGGTGGCTGTAGAAGTCTTTGGCCTTGTCCAACAATTGCTTCCGTCAGTT
GCCATTTTGAATCAGAAGTATGCACCGCCTGCCTTCAACCCTAATCAGTCGACAGATAGCACCACAGGAAACCAGCCTGAACAGGGCCTC
TCTGCTTGTACAACCTCCAGTCACTATGCTGTCATAGAGAGTGAGCACCCGTATAAACCTGCCTGTGTGATGCATTACAAGGTGACATTC
CCAGAATGTGTGAGGTGGATGACAATCGAATTTGACCCTCAGTGTGGTACTGCACAGTCAGAAGATGTCCTTCGTTTGTTGATTCCTGTC
AGAACTGTTCAGAATTCAGGATATGGACCAAAATTGACATCTGTTCATGAAAATCTTAATTCATGGATAGAATTAAAGAAATTTTCAGGA
TCCTCTGGGTGGCCTACTATGGTTTTGGTGTTGCCAGGAAATGAGGCCCTTTTTTCATTGGAGACTGCATCAGATTATGTGAAAGATGAC
AAAGCTTCTTTCTATGGTTTTAAGTGTTTTGCAATTGGATATGAATTTAGCCCTGGACCTGATGAGGGAGTCATCCAATTGGAAAAAGAA
TTAGCCAATCTTGGTGGGGTTTGTGCAGCAGCTCTGATGAAGAAGGACCTAGCACTTCCTATTGGTAATGAATTAGAAGAAGACCTTGAA
ATTCTTGAGGAGGCTGCATTGCAGGTGTGCAAAACCCATTCTGGAATTCTTGGAAAGGGTCTAGCTCTTTCTCATTCACCAACTATATTA
GAAGCACTTGAGGGAAATTTACCACTCCAAATCCAAAGCAATGAACAGTCTTTTCTGGATGATTTTATTGCCTGTGTCCCAGGATCAAGT
GGTGGAAGGCTTGCAAGGTGGCTTCAGCCAGATTCATATGCGGATCCTCAGAAAACATCTTTGATCCTGAATAAGGATGATATTCGTTGT
GGTTGGCCTACCACCATAACTGTTCAAACAAAAGACCAGTATGGGGATGTGGTACATGTTCCCAATATGAAGGAATTGGCAGCAATGAAA
CAGATTCTCGTTAAGATGCATAGTAAACATTCTGAGAACAGCTTACTTCTCACTAAAACAGAACCAAAACATGTGACAGAAAATCAGAAA
TCAAAGACTTTGAATGTGCCTAAAGAGCATGAAGACAATATATTTACACCTAAACCAACACTCTTTACTAAAAAAGAAGCACCTGAGTGG
TCTAAGAAACAAAAGATGAAGACCTAGTGTTTTGGATGGGAAGCACCTGTAGACCATTATATACTCCTGAAGTTCTTTTTCTGATGGAAA
ACAAAATTCAGCTTAATCGTGTACTCAGCATTTTTTAAATAACAATGTTTATTTGAACTAATATTAAATTAACAAATTCAGTGTAATCAA
AATGTGTAAAGAACAATCAATATACTTTATTTTTTTTTCTATTTTATAAAATAAATATATATGCTATGCTTTAAATTTTGGAGCTTTCAT
AAATGTTCAATGCATTTTAAGTGTGTGGCTTATAAATATTTTGGTATTTTTCTATACTACGTAAATTCTGAGTTTAAATGTCATACACAA
ATACTAAGACACTTTGCATTTTTAAAAATTAAGAATCATTTGTGAAGTCCACTACGAGGTACTTCAAAAGCCCAGTAATGGTGGTCAGAT
ACCATGTAGATGGATACAGATTGTTGACTCTTTTGAAGTTGTTTTTTTCTTATATTTTATATTACCATTAACCAATAAAATCTGGCAGAA
AGTCTGCTATTCCATTGGTAA

>56206_56206_1_MYCBP2-PIBF1_MYCBP2_chr13_77730193_ENST00000407578_PIBF1_chr13_73572960_ENST00000326291_length(amino acids)=2407AA_BP=2333
MEKGCVCARVSARPARGDEAAAAAAAARMMMCAATASPAAASSGLGGDGFYPAATFSSSPAPGALFMPVPDGSVAAAGLGLGLPAADSRG
HYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRNKKILNKKKLKRKQKSKSKVKTRSKSENLENTVIIPDIKLHSNPSAFNIYC
NVRHCVLEWQKKEISLAAASKNSVQSGESDSDEEEESKEPPIKLPKIIEVGLCEVFELIKETRFSHPSLCLRSLQALLNVLQGQQPEGLQ
SEPPEVLESLFQLLLEITVRSTGMNDSTGQSLTALSCACLFSLVASWGETGRTLQAISAILTNNGSHACQTIQVPTILNSLQRSVQAVLV
GKIQIQDWFSNGIKKAALMHKWPLKEISVDEDDQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVRGHIYNSTSRIRNRKEKKSWLGYAQGY
LLYRDVNNHSMTAIRISPETLEQDGTVMLPDCHTEGQNILFTDGEYINQIAASRDDGFVVRIFATSTEPVLQQELQLKLARKCLHACGIS
LFDLEKDLHIISTGFDEESAILGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITKSPKIVHFSVGHDGSHALLVAEDGS
IFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHFVTQVAMGKAH
TCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEEELDEKDEKSMMCPPGMHKWKLEQCMVCTVCGDCTGYGASC
VSSGRPDRVPGGICGCGSGESGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPVPGVNIEEHLQLRQEEKRQRVIRRHRL
EEGRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVY
TFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKAT
WIGASGDQTFLRIDEALINSHVLATSEIFASKHIIGLVPASISEPPPFKCLLINKVDGSCKTFNDSEQEDLQGFGVCLDPVYDVIWRFRP
NTRELWCYNAVVADARLPSAADMQSRCSILSPELALPTGSRALTTRSHAALHILGCLDTLAAMQDLKMGVASTEEETQAVMKVYSKEDYS
VVNRFESHGGGWGYSAHSVEAIRFSADTDILLGGLGLFGGRGEYTAKIKLFELGPDGGDHETDGDLLAETDVLAYDCAAREKYAMMFDEP
VLLQAGWWYVAWARVSGPSSDCGSHGQASITTDDGVVFQFKSSKKSNNGTDVNAGQIPQLLYRLPTSDGSASKGKQQTSEPVHILKRSFA
RTVSVECFESLLSILHWSWTTLVLGVEELRGLKGFQFTATLLDLERLRFVGTCCLRLLRVYTCEIYPVSATGKAVVEETSKLAECIGKTR
TLLRKILSEGVDHCMVKLDNDPQGYLSQPLSLLEAVLQECHNTFTACFHSFYPTPALQWACLCDLLNCLDQDIQEANFKTSSSRLLAAVM
SALCHTSVKLTSIFPIAYDGEVLLRSIVKQVSTENDSTLVHRFPLLVAHMEKLSQSEENISGMTSFREVLEKMLVIVVLPVRNSLRRENE
LFSSHLVSNTCGLLASIVSELTASALGSEVDGLNSLHSVKASANRFTKTSQGRSWNTGNGSPDAICFSVDKPGIVVVGFSVYGGGGIHEY
ELEVLVDDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGSRTANGDGGMTTVQCPDGVTFTFST
CSLSSNGTNQTRGQIPQILYYRSEFDGDLQSQLLSKANEEDKNCSRALSVVSTVVRASKDLLHRALAVDADDIPELLSSSSLFSMLLPLI
IAYIGPVAAAIPKVAVEVFGLVQQLLPSVAILNQKYAPPAFNPNQSTDSTTGNQPEQGLSACTTSSHYAVIESEHPYKPACVMHYKVTFP
ECVRWMTIEFDPQCGTAQSEDVLRLLIPVRTVQNSGYGPKLTSVHENLNSWIELKKFSGSSGWPTMVLVLPGNEALFSLETASDYVKDDK
ASFYGFKCFAIGYEFSPGPDEGVIQLEKELANLGGVCAAALMKKDLALPIGNELEEDLEILEEAALQVCKTHSGILGKGLALSHSPTILE
ALEGNLPLQIQSNEQSFLDDFIACVPGSSGGRLARWLQPDSYADPQKTSLILNKDDIRCGWPTTITVQTKDQYGDVVHVPNMKELAAMKQ
ILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQKMKT

--------------------------------------------------------------
>56206_56206_2_MYCBP2-PIBF1_MYCBP2_chr13_77730193_ENST00000544440_PIBF1_chr13_73572960_ENST00000326291_length(transcript)=7578nt_BP=6819nt
GCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGT
CACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGC
GGCAGCGCTGGACACCCAGCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAAGTGAAG
ACAAGAAGCAAGTCTGAAAACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATTTACTGT
AATGTACGCCATTGCGTTCTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAATCAGAT
AGTGATGAAGAAGAGGAATCCAAAGAGCCCCCTATCAAGCTTCCAAAGATTATTGAGGTTGGCCTTTGTGAAGTTTTTGAATTGATCAAA
GAGACACGATTTTCTCATCCATCCCTGTGTCTCAGGAGTCTCCAAGCCCTGCTCAACGTGCTGCAGGGCCAGCAGCCAGAAGGCCTCCAG
TCTGAGCCACCTGAGGTCCTAGAGTCTCTCTTCCAGCTTCTTTTGGAAATCACCGTTCGAAGTACTGGGATGAATGACAGCACAGGACAG
TCCTTAACAGCACTTTCCTGTGCTTGCCTCTTTAGTCTGGTGGCTTCTTGGGGAGAAACAGGAAGGACACTTCAGGCCATCTCTGCTATC
CTCACCAACAATGGAAGCCATGCTTGCCAAACTATTCAGGTGCCAACAATTCTAAATTCGCTACAGAGAAGTGTACAAGCAGTTTTGGTG
GGAAAAATTCAAATTCAGGACTGGTTTAGTAATGGCATTAAGAAAGCAGCTTTAATGCACAAGTGGCCATTAAAAGAAATATCTGTTGAT
GAAGATGACCAATGTCTACTTCAGAATGATGGATTTTTTCTTTATCTATTATGCAAGGATGGATTATATAAAATAGGCTCTGGATACAGT
GGAACAGTTAGGGGCCATATATACAATTCTACATCCCGTATTAGAAACAGAAAAGAAAAAAAGTCTTGGTTAGGGTATGCTCAGGGTTAT
TTATTATATAGAGATGTGAATAACCACAGCATGACAGCCATAAGGATAAGCCCTGAAACACTGGAGCAAGATGGTACTGTGATGTTACCA
GATTGCCACACTGAAGGTCAAAATATTTTATTCACTGATGGAGAATATATTAATCAGATAGCTGCTTCAAGAGATGATGGCTTTGTTGTC
AGAATATTTGCCACAAGCACTGAACCTGTTCTACAGCAAGAATTGCAACTTAAACTGGCTAGAAAATGCTTACATGCCTGTGGTATCTCA
CTATTCGATCTGGAAAAGGACTTGCATATTATAAGTACAGGATTTGATGAGGAGTCAGCAATTCTTGGTGCAGGACGAGAGTTTGCGCTA
ATGAAAACAGCAAATGGAAAGATATATTACACTGGCAAATACCAGAGTCTTGGAATCAAACAAGGTGGTCCTTCAGCAGGAAAATGGGTT
GAGCTACCAATTACAAAATCTCCAAAGATAGTACACTTCTCAGTTGGACACGATGGCTCTCACGCCCTTTTAGTTGCAGAAGATGGGAGC
ATATTCTTTACAGGATCTGCTAGTAAAGGAGAAGATGGAGAATCAACTAAGAGCAGACGGCAATCCAAACCTTATAAACCTAAAAAGATA
ATTAAGATGGAAGGAAAGATTGTGGTATATACAGCCTGCAATAATGGAAGTAGTTCTGTTATTTCTAAAGATGGAGAACTCTACATGTTT
GGAAAAGATGCCATTTACTCTGATAGTTCAAGTTTGGTAACTGATTTGAAGGGCCATTTTGTAACTCAGGTAGCTATGGGCAAAGCTCAC
ACTTGTGTTTTAATGAAGAATGGAGAGGTGTGGACATTTGGTGTAAATAATAAAGGACAGTGTGGACGAGATACTGGTGCCATGAACCAA
GGTGGGAAAGGGTTTGGAGTTGAAAATATGGCAACAGCAATGGATGAAGACCTGGAAGAAGAACTAGATGAAAAAGATGAGAAGTCTATG
ATGTGCCCTCCAGGCATGCACAAATGGAAGCTGGAGCAGTGCATGGTTTGCACTGTCTGTGGAGACTGTACAGGTTATGGAGCCAGCTGT
GTCAGTAGTGGACGGCCAGACAGAGTCCCCGGAGGGATCTGTGGTTGTGGTTCCGGAGAATCTGGTTGTGCTGTGTGTGGATGTTGCAAG
GCCTGTGCAAGAGAGTTAGATGGTCAAGAGGCAAGACAAAGAGGAATTCTTGATGCAGTGAAAGAAATGATACCTTTAGATCTTCTTTTA
GCTGTCCCAGTGCCCGGGGTTAACATTGAAGAACACCTTCAGTTACGACAAGAAGAAAAACGGCAACGTGTAATCAGAAGGCACAGATTA
GAGGAAGGAAGAGGCCCCCTTGTATTTGCTGGTCCTATTTTTATGAACCATCGAGAACAGGCTCTAGCCAGACTCAGATCCCATCCAGCA
CAGCTAAAGCATAAACGGGACAAGCACAAAGATGGAAGTGGAGAAAGAGGCGAAAAGGATGCAAGCAAAATCACAACATACCCTCCAGGC
TCTGTGCGATTTGACTGTGAGCTCCGGGCAGTCCAAGTCAGCTGTGGATTTCACCATTCAGTGGTTTTAATGGAAAATGGAGATGTCTAT
ACATTTGGTTATGGGCAGCATGGGCAGCTAGGACATGGAGATGTCAACTCCAGGGGATGTCCCACTCTTGTTCAAGCATTGCCAGGCCCT
AGCACACAAGTCACTGCAGGCAGCAACCATACGGCAGTACTTTTAATGGATGGACAGGTCTTCACATTTGGAAGTTTTTCTAAAGGACAA
CTGGGCAGACCAATTTTGGATGTGCCATATTGGAATGCAAAGCCAGCTCCCATGCCTAACATTGGATCAAAATATGGAAGAAAAGCTACT
TGGATAGGTGCAAGTGGGGACCAAACTTTTTTACGAATTGATGAAGCACTTATTAATTCTCATGTACTTGCTACATCAGAAATTTTTGCC
AGTAAACACATAATAGGCTTGGTACCTGCTTCTATATCAGAACCTCCTCCATTTAAATGCCTTCTGATAAATAAAGTGGATGGGAGTTGT
AAAACTTTTAATGACTCAGAACAAGAGGATCTGCAAGGATTTGGTGTGTGTCTTGATCCTGTATATGATGTAATTTGGAGGTTTCGACCA
AATACTAGAGAGCTGTGGTGTTACAATGCGGTGGTTGCTGATGCCAGGCTTCCCTCTGCAGCAGACATGCAGTCCAGATGTAGTATCCTA
AGTCCTGAACTTGCCTTACCAACAGGATCAAGGGCCCTCACTACCCGATCTCATGCAGCTTTGCACATTTTAGGTTGTCTTGATACCTTG
GCAGCTATGCAGGACTTAAAAATGGGTGTTGCAAGTACAGAGGAAGAGACTCAAGCAGTAATGAAGGTTTATTCTAAAGAAGATTATAGT
GTGGTAAACAGGTTTGAAAGTCATGGAGGAGGCTGGGGTTATTCTGCCCATTCAGTAGAAGCTATACGTTTCAGTGCCGACACTGATATT
TTACTTGGTGGTCTTGGTCTGTTTGGAGGTAGAGGAGAATATACTGCTAAAATTAAGCTGTTTGAATTGGGTCCTGATGGAGGAGATCAT
GAAACTGATGGTGACCTTCTTGCAGAGACTGATGTATTGGCTTATGACTGTGCTGCTAGAGAAAAATATGCAATGATGTTTGATGAGCCT
GTTCTCCTGCAAGCTGGGTGGTGGTATGTGGCATGGGCCCGAGTGTCAGGACCCAGCAGTGACTGTGGATCTCATGGACAGGCATCTATT
ACCACAGATGATGGGGTTGTTTTCCAGTTCAAGAGTTCAAAGAAATCAAATAATGGTACAGATGTTAATGCGGGTCAGATACCTCAGTTA
TTATACAGACTTCCAACCAGTGATGGCAGTGCTTCAAAAGGCAAACAGCAAACCAGTGAACCTGTACACATTTTAAAGAGGTCTTTTGCA
AGAACTGTCTCAGTGGAATGTTTTGAGTCATTGTTGAGTATTCTTCACTGGAGCTGGACCACCTTAGTCTTAGGAGTTGAAGAACTTAGA
GGATTAAAAGGATTCCAGTTCACAGCTACACTCCTAGATTTAGAGAGACTGCGCTTTGTGGGTACCTGTTGTCTGAGGTTATTGCGTGTC
TATACCTGTGAAATTTACCCAGTGTCAGCTACAGGAAAAGCAGTTGTAGAAGAAACTAGCAAATTAGCAGAGTGTATTGGAAAAACCAGA
ACTTTGTTAAGAAAAATTTTATCAGAAGGAGTTGATCACTGCATGGTGAAATTGGATAATGATCCTCAAGGATATCTCAGTCAACCCTTG
AGTCTTCTAGAAGCTGTCCTTCAGGAATGTCATAATACTTTCACTGCCTGCTTTCATTCTTTCTACCCAACTCCTGCCTTACAGTGGGCT
TGCCTTTGTGATCTGCTGAATTGTTTGGATCAGGATATCCAAGAAGCAAACTTCAAGACATCAAGTAGCCGACTCCTTGCAGCTGTTATG
TCAGCTCTGTGTCACACGTCTGTTAAGCTGACTTCCATCTTCCCGATTGCGTATGATGGAGAAGTATTACTACGATCAATTGTTAAACAA
GTTAGTACAGAGAACGACTCAACACTAGTTCATCGTTTTCCCCTTTTGGTGGCACATATGGAAAAACTCAGCCAGAGTGAAGAGAATATC
TCAGGGATGACAAGCTTCCGTGAAGTTCTGGAGAAAATGCTGGTCATTGTTGTGCTACCAGTCAGGAACAGCCTGAGGAGAGAAAATGAA
CTCTTCTCCTCCCACCTCGTCTCTAACACCTGTGGATTACTGGCCAGCATTGTCAGTGAACTGACAGCGTCAGCCCTGGGATCTGAGGTT
GATGGACTTAATTCTCTTCACTCTGTAAAAGCTAGTGCTAACCGATTTACAAAAACAAGTCAGGGCAGAAGTTGGAACACTGGGAACGGG
TCCCCTGATGCAATCTGTTTTTCAGTAGACAAACCTGGAATAGTTGTGGTTGGTTTCTCTGTCTATGGAGGAGGTGGAATTCATGAATAT
GAATTAGAGGTGTTGGTTGATGATAGTGAACATGCAGGAGATTCAACTCATTCCCACAGATGGACATCTCTGGAATTAGTGAAAGGAACG
TACACAACGGATGACTCACCCAGTGATATAGCTGAGATCAGACTTGACAAAGTGGTTCCTTTAAAGGAAAATGTTAAATATGCTGTGCGC
TTGAGGAACTATGGAAGCCGTACAGCCAATGGAGATGGAGGAATGACCACAGTTCAGTGCCCTGATGGTGTGACATTCACATTCAGCACG
TGCAGCTTGAGCAGTAACGGCACAAACCAAACCAGAGGACAGATCCCACAGATACTCTACTATAGGAGTGAATTTGATGGAGATTTACAA
TCCCAACTTCTGAGTAAAGCCAATGAAGAAGATAAAAACTGTAGCAGAGCATTGTCTGTTGTAAGCACTGTCGTTCGAGCCTCTAAGGAC
CTCCTGCACAGAGCTCTTGCTGTGGATGCTGATGACATTCCAGAACTGCTGAGTTCTTCCAGTCTGTTTTCCATGCTGCTCCCCCTTATT
ATAGCCTACATAGGACCAGTAGCTGCTGCTATTCCCAAGGTGGCTGTAGAAGTCTTTGGCCTTGTCCAACAATTGCTTCCGTCAGTTGCC
ATTTTGAATCAGAAGTATGCACCGCCTGCCTTCAACCCTAATCAGTCGACAGATAGCACCACAGGAAACCAGCCTGAACAGGGCCTCTCT
GCTTGTACAACCTCCAGTCACTATGCTGTCATAGAGAGTGAGCACCCGTATAAACCTGCCTGTGTGATGCATTACAAGGTGACATTCCCA
GAATGTGTGAGGTGGATGACAATCGAATTTGACCCTCAGTGTGGTACTGCACAGTCAGAAGATGTCCTTCGTTTGTTGATTCCTGTCAGA
ACTGTTCAGAATTCAGGATATGGACCAAAATTGACATCTGTTCATGAAAATCTTAATTCATGGATAGAATTAAAGAAATTTTCAGGATCC
TCTGGGTGGCCTACTATGGTTTTGGTGTTGCCAGGAAATGAGGCCCTTTTTTCATTGGAGACTGCATCAGATTATGTGAAAGATGACAAA
GCTTCTTTCTATGGTTTTAAGTGTTTTGCAATTGGATATGAATTTAGCCCTGGACCTGATGAGGGAGTCATCCAATTGGAAAAAGAATTA
GCCAATCTTGGTGGGGTTTGTGCAGCAGCTCTGATGAAGAAGGACCTAGCACTTCCTATTGGTAATGAATTAGAAGAAGACCTTGAAATT
CTTGAGGAGGCTGCATTGCAGGTGTGCAAAACCCATTCTGGAATTCTTGGAAAGGGTCTAGCTCTTTCTCATTCACCAACTATATTAGAA
GCACTTGAGGGAAATTTACCACTCCAAATCCAAAGCAATGAACAGTCTTTTCTGGATGATTTTATTGCCTGTGTCCCAGGATCAAGTGGT
GGAAGGCTTGCAAGGTGGCTTCAGCCAGATTCATATGCGGATCCTCAGAAAACATCTTTGATCCTGAATAAGGATGATATTCGTTGTGGT
TGGCCTACCACCATAACTGTTCAAACAAAAGACCAGTATGGGGATGTGGTACATGTTCCCAATATGAAGGAATTGGCAGCAATGAAACAG
ATTCTCGTTAAGATGCATAGTAAACATTCTGAGAACAGCTTACTTCTCACTAAAACAGAACCAAAACATGTGACAGAAAATCAGAAATCA
AAGACTTTGAATGTGCCTAAAGAGCATGAAGACAATATATTTACACCTAAACCAACACTCTTTACTAAAAAAGAAGCACCTGAGTGGTCT
AAGAAACAAAAGATGAAGACCTAGTGTTTTGGATGGGAAGCACCTGTAGACCATTATATACTCCTGAAGTTCTTTTTCTGATGGAAAACA
AAATTCAGCTTAATCGTGTACTCAGCATTTTTTAAATAACAATGTTTATTTGAACTAATATTAAATTAACAAATTCAGTGTAATCAAAAT
GTGTAAAGAACAATCAATATACTTTATTTTTTTTTCTATTTTATAAAATAAATATATATGCTATGCTTTAAATTTTGGAGCTTTCATAAA
TGTTCAATGCATTTTAAGTGTGTGGCTTATAAATATTTTGGTATTTTTCTATACTACGTAAATTCTGAGTTTAAATGTCATACACAAATA
CTAAGACACTTTGCATTTTTAAAAATTAAGAATCATTTGTGAAGTCCACTACGAGGTACTTCAAAAGCCCAGTAATGGTGGTCAGATACC
ATGTAGATGGATACAGATTGTTGACTCTTTTGAAGTTGTTTTTTTCTTATATTTTATATTACCATTAACCAATAAAATCTGGCAGAAAGT
CTGCTATTCCATTGGTAA

>56206_56206_2_MYCBP2-PIBF1_MYCBP2_chr13_77730193_ENST00000544440_PIBF1_chr13_73572960_ENST00000326291_length(amino acids)=2343AA_BP=2269
MFMPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRNKKILNKKKLKRKQKSKSKVKTRSK
SENLENTVIIPDIKLHSNPSAFNIYCNVRHCVLEWQKKEISLAAASKNSVQSGESDSDEEEESKEPPIKLPKIIEVGLCEVFELIKETRF
SHPSLCLRSLQALLNVLQGQQPEGLQSEPPEVLESLFQLLLEITVRSTGMNDSTGQSLTALSCACLFSLVASWGETGRTLQAISAILTNN
GSHACQTIQVPTILNSLQRSVQAVLVGKIQIQDWFSNGIKKAALMHKWPLKEISVDEDDQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVR
GHIYNSTSRIRNRKEKKSWLGYAQGYLLYRDVNNHSMTAIRISPETLEQDGTVMLPDCHTEGQNILFTDGEYINQIAASRDDGFVVRIFA
TSTEPVLQQELQLKLARKCLHACGISLFDLEKDLHIISTGFDEESAILGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPI
TKSPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDA
IYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEEELDEKDEKSMMCPP
GMHKWKLEQCMVCTVCGDCTGYGASCVSSGRPDRVPGGICGCGSGESGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPV
PGVNIEEHLQLRQEEKRQRVIRRHRLEEGRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRF
DCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLGRP
ILDVPYWNAKPAPMPNIGSKYGRKATWIGASGDQTFLRIDEALINSHVLATSEIFASKHIIGLVPASISEPPPFKCLLINKVDGSCKTFN
DSEQEDLQGFGVCLDPVYDVIWRFRPNTRELWCYNAVVADARLPSAADMQSRCSILSPELALPTGSRALTTRSHAALHILGCLDTLAAMQ
DLKMGVASTEEETQAVMKVYSKEDYSVVNRFESHGGGWGYSAHSVEAIRFSADTDILLGGLGLFGGRGEYTAKIKLFELGPDGGDHETDG
DLLAETDVLAYDCAAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSDCGSHGQASITTDDGVVFQFKSSKKSNNGTDVNAGQIPQLLYRL
PTSDGSASKGKQQTSEPVHILKRSFARTVSVECFESLLSILHWSWTTLVLGVEELRGLKGFQFTATLLDLERLRFVGTCCLRLLRVYTCE
IYPVSATGKAVVEETSKLAECIGKTRTLLRKILSEGVDHCMVKLDNDPQGYLSQPLSLLEAVLQECHNTFTACFHSFYPTPALQWACLCD
LLNCLDQDIQEANFKTSSSRLLAAVMSALCHTSVKLTSIFPIAYDGEVLLRSIVKQVSTENDSTLVHRFPLLVAHMEKLSQSEENISGMT
SFREVLEKMLVIVVLPVRNSLRRENELFSSHLVSNTCGLLASIVSELTASALGSEVDGLNSLHSVKASANRFTKTSQGRSWNTGNGSPDA
ICFSVDKPGIVVVGFSVYGGGGIHEYELEVLVDDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNY
GSRTANGDGGMTTVQCPDGVTFTFSTCSLSSNGTNQTRGQIPQILYYRSEFDGDLQSQLLSKANEEDKNCSRALSVVSTVVRASKDLLHR
ALAVDADDIPELLSSSSLFSMLLPLIIAYIGPVAAAIPKVAVEVFGLVQQLLPSVAILNQKYAPPAFNPNQSTDSTTGNQPEQGLSACTT
SSHYAVIESEHPYKPACVMHYKVTFPECVRWMTIEFDPQCGTAQSEDVLRLLIPVRTVQNSGYGPKLTSVHENLNSWIELKKFSGSSGWP
TMVLVLPGNEALFSLETASDYVKDDKASFYGFKCFAIGYEFSPGPDEGVIQLEKELANLGGVCAAALMKKDLALPIGNELEEDLEILEEA
ALQVCKTHSGILGKGLALSHSPTILEALEGNLPLQIQSNEQSFLDDFIACVPGSSGGRLARWLQPDSYADPQKTSLILNKDDIRCGWPTT
ITVQTKDQYGDVVHVPNMKELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQK
MKT

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Fusion Gene PPI Analysis for MYCBP2-PIBF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MYCBP2-PIBF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MYCBP2-PIBF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C4540389	JOUBERT SYNDROME 33	2	GENOMICS_ENGLAND;UNIPROT
Tgene		C0000821	Threatened abortion	1	CTD_human
Tgene		C0004134	Ataxia	1	GENOMICS_ENGLAND
Tgene		C0424605	Developmental delay (disorder)	1	GENOMICS_ENGLAND
Tgene		C0431399	Familial aplasia of the vermis	1	GENOMICS_ENGLAND;ORPHANET
Tgene		C0557874	Global developmental delay	1	GENOMICS_ENGLAND
Tgene		C4313693	Vermis hypoplasia	1	GENOMICS_ENGLAND
Tgene		C4551568	Joubert syndrome 1	1	ORPHANET

Fusion Gene Studies in Kim Lab

Fusion gene:MYCBP2-PIBF1 (FusionGDB2 ID:HG23077TG10464)

Fusion Gene Summary for MYCBP2-PIBF1

Fusion Gene ORF analysis for MYCBP2-PIBF1

Fusion Genomic Features for MYCBP2-PIBF1

Fusion Protein Features for MYCBP2-PIBF1

Fusion Gene Sequence for MYCBP2-PIBF1

Fusion Gene PPI Analysis for MYCBP2-PIBF1

Related Drugs for MYCBP2-PIBF1

Related Diseases for MYCBP2-PIBF1

Fusion Gene Studies
in Kim Lab