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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYCBP2-TAF6L (FusionGDB2 ID:HG23077TG10629)

Fusion Gene Summary for MYCBP2-TAF6L

check button Fusion gene summary
Fusion gene informationFusion gene name: MYCBP2-TAF6L
Fusion gene ID: hg23077tg10629
HgeneTgene
Gene symbol

MYCBP2

TAF6L

Gene ID

23077

10629

Gene nameMYC binding protein 2TATA-box binding protein associated factor 6 like
SynonymsMyc-bp2|PAM|PHR1|PhrPAF65A
Cytomap('MYCBP2')('TAF6L')

13q22.3

11q12.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MYCBP2HighwireMYC binding protein 2, E3 ubiquitin protein ligasePAM/Highwire/RPM-1 protein 1RING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with MycTAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6LPAF65-alphaPCAF-associated factor 65-alphaTAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDap300/CBP-associated factor (PCAF
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000360084, ENST00000357337, 
ENST00000407578, ENST00000544440, 
ENST00000482517, 
Fusion gene scores* DoF score14 X 16 X 8=17924 X 4 X 4=64
# samples 154
** MAII scorelog2(15/1792*10)=-3.57853623156172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYCBP2 [Title/Abstract] AND TAF6L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYCBP2(77900609)-TAF6L(62549585), # samples:2
Anticipated loss of major functional domain due to fusion event.MYCBP2-TAF6L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MYCBP2-TAF6L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYCBP2

GO:0016567

protein ubiquitination

29643511

HgeneMYCBP2

GO:0031398

positive regulation of protein ubiquitination

20534529

TgeneTAF6L

GO:0043966

histone H3 acetylation

11564863


check buttonFusion gene breakpoints across MYCBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TAF6L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-ZG-A9LZ-01AMYCBP2chr13

77900609

-TAF6Lchr11

62549585

+


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Fusion Gene ORF analysis for MYCBP2-TAF6L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000360084ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
In-frameENST00000357337ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
In-frameENST00000407578ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
In-frameENST00000544440ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
intron-3CDSENST00000482517ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544440MYCBP2chr1377900609-ENST00000294168TAF6Lchr1162549585+15152062271468413
ENST00000407578MYCBP2chr1377900609-ENST00000294168TAF6Lchr1162549585+18785695901831413
ENST00000357337MYCBP2chr1377900609-ENST00000294168TAF6Lchr1162549585+15902813021543413

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544440ENST00000294168MYCBP2chr1377900609-TAF6Lchr1162549585+0.36875490.6312451
ENST00000407578ENST00000294168MYCBP2chr1377900609-TAF6Lchr1162549585+0.246745020.753255
ENST00000357337ENST00000294168MYCBP2chr1377900609-TAF6Lchr1162549585+0.294241580.70575845

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Fusion Genomic Features for MYCBP2-TAF6L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MYCBP2-TAF6L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:77900609/chr11:62549585)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284103_126624641.0Compositional biasLys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2842720_2844624641.0Compositional biasSer-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2843194_3215624641.0Compositional biasLys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2843262_3293624641.0Compositional biasNote=Gly-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284766_814624641.0Compositional biasCys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183103_126624641.0Compositional biasLys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1832720_2844624641.0Compositional biasSer-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1833194_3215624641.0Compositional biasLys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1833262_3293624641.0Compositional biasNote=Gly-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183766_814624641.0Compositional biasCys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2843719_3897624641.0DomainDOC
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1833719_3897624641.0DomainDOC
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2841235_1386624641.0RegionPHR domain 1
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2841726_1884624641.0RegionPHR domain 2
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2842022_2550624641.0RegionRAE1 binding
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2844539_4676624641.0RegionTandem cysteine domain
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1831235_1386624641.0RegionPHR domain 1
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1831726_1884624641.0RegionPHR domain 2
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1832022_2550624641.0RegionRAE1 binding
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1834539_4676624641.0RegionTandem cysteine domain
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2841010_1066624641.0RepeatRCC1 5
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2842341_2443624641.0RepeatFilamin
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284600_655624641.0RepeatRCC1 1
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284699_755624641.0RepeatRCC1 2
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284907_957624641.0RepeatRCC1 3
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284958_1008624641.0RepeatRCC1 4
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1831010_1066624641.0RepeatRCC1 5
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1832341_2443624641.0RepeatFilamin
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183600_655624641.0RepeatRCC1 1
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183699_755624641.0RepeatRCC1 2
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183907_957624641.0RepeatRCC1 3
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183958_1008624641.0RepeatRCC1 4
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2844428_4479624641.0Zinc fingerRING-type%3B atypical
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1834428_4479624641.0Zinc fingerRING-type%3B atypical


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Fusion Gene Sequence for MYCBP2-TAF6L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56212_56212_1_MYCBP2-TAF6L_MYCBP2_chr13_77900609_ENST00000357337_TAF6L_chr11_62549585_ENST00000294168_length(transcript)=1590nt_BP=281nt
GGCGGCGGCAGTGGCGGCACCGCCTCCTCCTCACATTCCCGGGGTGGCGGGGTTAGATGAGCGGCCCCAGTAGCGGCGCCGGGGGCGCTG
TTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGTCACTACCAGCTGCTG
CTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGCGGCAGCGCTGGACAC
CCAGCCTCCAGGTGAAATCTGTAAGCCATGACCTGGAGCAACTGCACCGGCTGCTGCAGGTGGCACGGAGCCTATTTCGTAATCCGCACC
TGTGCTTGGGGCCCTATGTCCGCTGTCTGGTGGGCAGTGTCCTCTACTGTGTCCTGGAGCCACTGGCTGCCTCCATCAACCCCCTGAATG
ACCACTGGACTCTGCGGGATGGGGCTGCCCTCCTGCTCAGCCACATCTTCTGGACTCATGGGGACCTTGTAAGTGGCCTCTATCAGCATA
TCCTGCTATCCCTGCAGAAGATCCTGGCAGATCCTGTGCGGCCGCTCTGCTGCCACTATGGAGCCGTGGTGGGGCTGCATGCTCTTGGCT
GGAAGGCAGTAGAACGAGTCCTGTACCCACACCTGTCCACCTACTGGACAAACTTGCAGGCTGTGCTGGATGATTATTCAGTATCTAATG
CCCAGGTCAAAGCAGATGGACACAAAGTCTATGGAGCCATTCTGGTGGCGGTAGAGCGACTGCTGAAGATGAAGGCCCAGGCAGCAGAGC
CCAACAGGGGTGGCCCAGGTGGCAGGGGGTGCCGGCGCCTGGACGACCTGCCATGGGACAGCCTTCTCTTTCAAGAGTCGTCCTCCGGGG
GCGGTGCAGAACCCAGCTTTGGGTCCGGCCTCCCGCTGCCGCCAGGGGGCGCGGGGCCGGAGGACCCTTCTCTTTCGGTGACCCTGGCCG
ACATCTACCGGGAGCTCTACGCCTTCTTCGGTGACAGCTTGGCCACACGCTTTGGCACCGGCCAGCCTGCACCCACGGCTCCGCGGCCGC
CCGGGGACAAGAAGGAGCCGGCGGCAGCCCCGGACTCGGTGCGGAAGATGCCGCAGCTGACGGCAAGCGCCATAGTCAGCCCGCACGGCG
ACGAGAGCCCCCGGGGCAGCGGCGGAGGCGGCCCCGCGTCGGCCTCTGGGCCCGCCGCCTCTGAGAGCAGGCCCTTGCCGCGCGTGCATC
GGGCGCGCGGGGCACCCCGGCAGCAGGGCCCCGGGACCGGCACCCGCGACGTTTTCCAGAAGAGCCGTTTCGCCCCGCGCGGCGCCCCGC
ACTTTCGTTTCATCATAGCCGGGCGGCAGGCTGGGAGGCGCTGCCGCGGGCGCCTTTTCCAGACTGCCTTCCCCGCGCCGTACGGGCCTA
GCCCGGCCTCGCGCTACGTGCAGAAACTGCCCATGATCGGCCGTACCAGCCGCCCCGCCCGCCGGTGGGCGCTCTCGGACTACTCGCTGT

>56212_56212_1_MYCBP2-TAF6L_MYCBP2_chr13_77900609_ENST00000357337_TAF6L_chr11_62549585_ENST00000294168_length(amino acids)=413AA_BP=
MEQLHRLLQVARSLFRNPHLCLGPYVRCLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQHILLSLQKILAD
PVRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQAAEPNRGGPGGRGC
RRLDDLPWDSLLFQESSSGGGAEPSFGSGLPLPPGGAGPEDPSLSVTLADIYRELYAFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAP
DSVRKMPQLTASAIVSPHGDESPRGSGGGGPASASGPAASESRPLPRVHRARGAPRQQGPGTGTRDVFQKSRFAPRGAPHFRFIIAGRQA

--------------------------------------------------------------
>56212_56212_2_MYCBP2-TAF6L_MYCBP2_chr13_77900609_ENST00000407578_TAF6L_chr11_62549585_ENST00000294168_length(transcript)=1878nt_BP=569nt
CGGCGGCAGTGGCGGCACCGCCTCCTCCTCACATTCCCGGGGTGGCGGGGTTAGATGAGCGGCCCCAGTAGCGGCGAGGGCGGCGCGGGG
GGGAGGAGGAGAAGAAGGAGGAGGAGAAGGAGGTCGCTGTCTTTGTAGTCTCCCTGCTGCGGGAGCCAGAGGCCGCCGCCGGAGCCGTCG
TCGTTGGAAAAGGGCTGTGTGTGCGCGCGCGTGTCTGCCCGCCCGGCCCGCGGGGACGAGGCGGCGGCGGCGGCGGCGGCGGCGAGGATG
ATGATGTGCGCAGCGACTGCCTCCCCCGCCGCCGCCTCCTCGGGGCTCGGCGGGGACGGATTCTACCCAGCCGCCACCTTCTCTTCCTCC
CCGGCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGG
GGTCACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGG
GGCGGCAGCGCTGGACACCCAGCCTCCAGGTGAAATCTGTAAGCCATGACCTGGAGCAACTGCACCGGCTGCTGCAGGTGGCACGGAGCC
TATTTCGTAATCCGCACCTGTGCTTGGGGCCCTATGTCCGCTGTCTGGTGGGCAGTGTCCTCTACTGTGTCCTGGAGCCACTGGCTGCCT
CCATCAACCCCCTGAATGACCACTGGACTCTGCGGGATGGGGCTGCCCTCCTGCTCAGCCACATCTTCTGGACTCATGGGGACCTTGTAA
GTGGCCTCTATCAGCATATCCTGCTATCCCTGCAGAAGATCCTGGCAGATCCTGTGCGGCCGCTCTGCTGCCACTATGGAGCCGTGGTGG
GGCTGCATGCTCTTGGCTGGAAGGCAGTAGAACGAGTCCTGTACCCACACCTGTCCACCTACTGGACAAACTTGCAGGCTGTGCTGGATG
ATTATTCAGTATCTAATGCCCAGGTCAAAGCAGATGGACACAAAGTCTATGGAGCCATTCTGGTGGCGGTAGAGCGACTGCTGAAGATGA
AGGCCCAGGCAGCAGAGCCCAACAGGGGTGGCCCAGGTGGCAGGGGGTGCCGGCGCCTGGACGACCTGCCATGGGACAGCCTTCTCTTTC
AAGAGTCGTCCTCCGGGGGCGGTGCAGAACCCAGCTTTGGGTCCGGCCTCCCGCTGCCGCCAGGGGGCGCGGGGCCGGAGGACCCTTCTC
TTTCGGTGACCCTGGCCGACATCTACCGGGAGCTCTACGCCTTCTTCGGTGACAGCTTGGCCACACGCTTTGGCACCGGCCAGCCTGCAC
CCACGGCTCCGCGGCCGCCCGGGGACAAGAAGGAGCCGGCGGCAGCCCCGGACTCGGTGCGGAAGATGCCGCAGCTGACGGCAAGCGCCA
TAGTCAGCCCGCACGGCGACGAGAGCCCCCGGGGCAGCGGCGGAGGCGGCCCCGCGTCGGCCTCTGGGCCCGCCGCCTCTGAGAGCAGGC
CCTTGCCGCGCGTGCATCGGGCGCGCGGGGCACCCCGGCAGCAGGGCCCCGGGACCGGCACCCGCGACGTTTTCCAGAAGAGCCGTTTCG
CCCCGCGCGGCGCCCCGCACTTTCGTTTCATCATAGCCGGGCGGCAGGCTGGGAGGCGCTGCCGCGGGCGCCTTTTCCAGACTGCCTTCC
CCGCGCCGTACGGGCCTAGCCCGGCCTCGCGCTACGTGCAGAAACTGCCCATGATCGGCCGTACCAGCCGCCCCGCCCGCCGGTGGGCGC

>56212_56212_2_MYCBP2-TAF6L_MYCBP2_chr13_77900609_ENST00000407578_TAF6L_chr11_62549585_ENST00000294168_length(amino acids)=413AA_BP=
MEQLHRLLQVARSLFRNPHLCLGPYVRCLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQHILLSLQKILAD
PVRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQAAEPNRGGPGGRGC
RRLDDLPWDSLLFQESSSGGGAEPSFGSGLPLPPGGAGPEDPSLSVTLADIYRELYAFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAP
DSVRKMPQLTASAIVSPHGDESPRGSGGGGPASASGPAASESRPLPRVHRARGAPRQQGPGTGTRDVFQKSRFAPRGAPHFRFIIAGRQA

--------------------------------------------------------------
>56212_56212_3_MYCBP2-TAF6L_MYCBP2_chr13_77900609_ENST00000544440_TAF6L_chr11_62549585_ENST00000294168_length(transcript)=1515nt_BP=206nt
GCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGT
CACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGC
GGCAGCGCTGGACACCCAGCCTCCAGGTGAAATCTGTAAGCCATGACCTGGAGCAACTGCACCGGCTGCTGCAGGTGGCACGGAGCCTAT
TTCGTAATCCGCACCTGTGCTTGGGGCCCTATGTCCGCTGTCTGGTGGGCAGTGTCCTCTACTGTGTCCTGGAGCCACTGGCTGCCTCCA
TCAACCCCCTGAATGACCACTGGACTCTGCGGGATGGGGCTGCCCTCCTGCTCAGCCACATCTTCTGGACTCATGGGGACCTTGTAAGTG
GCCTCTATCAGCATATCCTGCTATCCCTGCAGAAGATCCTGGCAGATCCTGTGCGGCCGCTCTGCTGCCACTATGGAGCCGTGGTGGGGC
TGCATGCTCTTGGCTGGAAGGCAGTAGAACGAGTCCTGTACCCACACCTGTCCACCTACTGGACAAACTTGCAGGCTGTGCTGGATGATT
ATTCAGTATCTAATGCCCAGGTCAAAGCAGATGGACACAAAGTCTATGGAGCCATTCTGGTGGCGGTAGAGCGACTGCTGAAGATGAAGG
CCCAGGCAGCAGAGCCCAACAGGGGTGGCCCAGGTGGCAGGGGGTGCCGGCGCCTGGACGACCTGCCATGGGACAGCCTTCTCTTTCAAG
AGTCGTCCTCCGGGGGCGGTGCAGAACCCAGCTTTGGGTCCGGCCTCCCGCTGCCGCCAGGGGGCGCGGGGCCGGAGGACCCTTCTCTTT
CGGTGACCCTGGCCGACATCTACCGGGAGCTCTACGCCTTCTTCGGTGACAGCTTGGCCACACGCTTTGGCACCGGCCAGCCTGCACCCA
CGGCTCCGCGGCCGCCCGGGGACAAGAAGGAGCCGGCGGCAGCCCCGGACTCGGTGCGGAAGATGCCGCAGCTGACGGCAAGCGCCATAG
TCAGCCCGCACGGCGACGAGAGCCCCCGGGGCAGCGGCGGAGGCGGCCCCGCGTCGGCCTCTGGGCCCGCCGCCTCTGAGAGCAGGCCCT
TGCCGCGCGTGCATCGGGCGCGCGGGGCACCCCGGCAGCAGGGCCCCGGGACCGGCACCCGCGACGTTTTCCAGAAGAGCCGTTTCGCCC
CGCGCGGCGCCCCGCACTTTCGTTTCATCATAGCCGGGCGGCAGGCTGGGAGGCGCTGCCGCGGGCGCCTTTTCCAGACTGCCTTCCCCG
CGCCGTACGGGCCTAGCCCGGCCTCGCGCTACGTGCAGAAACTGCCCATGATCGGCCGTACCAGCCGCCCCGCCCGCCGGTGGGCGCTCT

>56212_56212_3_MYCBP2-TAF6L_MYCBP2_chr13_77900609_ENST00000544440_TAF6L_chr11_62549585_ENST00000294168_length(amino acids)=413AA_BP=
MEQLHRLLQVARSLFRNPHLCLGPYVRCLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQHILLSLQKILAD
PVRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQAAEPNRGGPGGRGC
RRLDDLPWDSLLFQESSSGGGAEPSFGSGLPLPPGGAGPEDPSLSVTLADIYRELYAFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAP
DSVRKMPQLTASAIVSPHGDESPRGSGGGGPASASGPAASESRPLPRVHRARGAPRQQGPGTGTRDVFQKSRFAPRGAPHFRFIIAGRQA

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Fusion Gene PPI Analysis for MYCBP2-TAF6L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYCBP2-TAF6L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYCBP2-TAF6L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource