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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:VWA8-RICTOR (FusionGDB2 ID:HG23078TG253260) |
Fusion Gene Summary for VWA8-RICTOR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VWA8-RICTOR | Fusion gene ID: hg23078tg253260 | Hgene | Tgene | Gene symbol | VWA8 | RICTOR | Gene ID | 23078 | 253260 |
| Gene name | von Willebrand factor A domain containing 8 | RPTOR independent companion of MTOR complex 2 | |
| Synonyms | KIAA0564|P7BP2 | AVO3|PIA|hAVO3 | |
| Cytomap | ('KIAA0564','VWA8')('RICTOR','RICTOR') 13q14.11 | 5p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | von Willebrand factor A domain-containing protein 8PEX7-binding protein 2 | rapamycin-insensitive companion of mTORAVO3 homologTORC2-specific protein AVO3pianissimo | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000281496, ENST00000379310, ENST00000478987, | ||
| Fusion gene scores | * DoF score | 13 X 12 X 6=936 | 1 X 1 X 1=1 |
| # samples | 13 | 1 | |
| ** MAII score | log2(13/936*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: VWA8 [Title/Abstract] AND RICTOR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KIAA0564(42534989)-RICTOR(38964994), # samples:1 VWA8(42534989)-RICTOR(38964994), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | VWA8-RICTOR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. VWA8-RICTOR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. VWA8-RICTOR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. VWA8-RICTOR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RICTOR | GO:0051896 | regulation of protein kinase B signaling | 15718470 |
| Fusion gene breakpoints across VWA8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across RICTOR (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-EE-A184-06A | KIAA0564 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - |
| ChimerDB4 | SKCM | TCGA-EE-A184-06A | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - |
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Fusion Gene ORF analysis for VWA8-RICTOR |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000281496 | ENST00000503698 | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - |
| 5CDS-intron | ENST00000379310 | ENST00000503698 | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - |
| In-frame | ENST00000281496 | ENST00000296782 | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - |
| In-frame | ENST00000281496 | ENST00000357387 | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - |
| In-frame | ENST00000379310 | ENST00000296782 | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - |
| In-frame | ENST00000379310 | ENST00000357387 | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - |
| intron-3CDS | ENST00000478987 | ENST00000296782 | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - |
| intron-3CDS | ENST00000478987 | ENST00000357387 | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - |
| intron-intron | ENST00000478987 | ENST00000503698 | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000379310 | VWA8 | chr13 | 42534989 | - | ENST00000357387 | RICTOR | chr5 | 38964994 | - | 8445 | 232 | 7 | 4059 | 1350 |
| ENST00000379310 | VWA8 | chr13 | 42534989 | - | ENST00000296782 | RICTOR | chr5 | 38964994 | - | 6416 | 232 | 7 | 4131 | 1374 |
| ENST00000281496 | VWA8 | chr13 | 42534989 | - | ENST00000357387 | RICTOR | chr5 | 38964994 | - | 8481 | 268 | 43 | 4095 | 1350 |
| ENST00000281496 | VWA8 | chr13 | 42534989 | - | ENST00000296782 | RICTOR | chr5 | 38964994 | - | 6452 | 268 | 43 | 4167 | 1374 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000379310 | ENST00000357387 | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - | 8.99E-05 | 0.9999101 |
| ENST00000379310 | ENST00000296782 | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - | 0.000212562 | 0.9997875 |
| ENST00000281496 | ENST00000357387 | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - | 9.36E-05 | 0.9999064 |
| ENST00000281496 | ENST00000296782 | VWA8 | chr13 | 42534989 | - | RICTOR | chr5 | 38964994 | - | 0.000218701 | 0.9997813 |
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Fusion Genomic Features for VWA8-RICTOR |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for VWA8-RICTOR |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:42534989/chr5:38964994) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | RICTOR | chr13:42534989 | chr5:38964994 | ENST00000296782 | 14 | 39 | 1016_1058 | 433 | 1733.0 | Compositional bias | Ser-rich | |
| Tgene | RICTOR | chr13:42534989 | chr5:38964994 | ENST00000357387 | 14 | 38 | 1016_1058 | 433 | 1709.0 | Compositional bias | Ser-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | VWA8 | chr13:42534989 | chr5:38964994 | ENST00000281496 | - | 1 | 26 | 1714_1896 | 54 | 1040.0 | Domain | VWFA |
| Hgene | VWA8 | chr13:42534989 | chr5:38964994 | ENST00000379310 | - | 1 | 45 | 1714_1896 | 54 | 1906.0 | Domain | VWFA |
| Hgene | VWA8 | chr13:42534989 | chr5:38964994 | ENST00000281496 | - | 1 | 26 | 447_454 | 54 | 1040.0 | Nucleotide binding | ATP |
| Hgene | VWA8 | chr13:42534989 | chr5:38964994 | ENST00000379310 | - | 1 | 45 | 447_454 | 54 | 1906.0 | Nucleotide binding | ATP |
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Fusion Gene Sequence for VWA8-RICTOR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >98629_98629_1_VWA8-RICTOR_VWA8_chr13_42534989_ENST00000281496_RICTOR_chr5_38964994_ENST00000296782_length(transcript)=6452nt_BP=268nt AGGTGCCGCTTCCTGTCCCCTTCTCCGCGCTGCCTCACGGTGCCTGCACGGGACGCCGCTCGATCCCCGAGCCCCCTCGCCGTCCCCGAC AGCCCCCCCGGCGCCATGCAATCCCGGCTTCTACTCCTCGGGGCACCCGGAGGCCACGGCGGCCCGGCCTCGCGGCGCATGCGGCTGCTC CTGCGGCAGGTGGTGCAGCGCAGGCCGGGTGGCGACAGGCAGCGGCCGGAGGTCAGACTGTTGCACGCCGGCTCGGGGGCCGACACAGGC AAACACAATTCTTCCTCATTCACATAGCCATCATTTACACTGCTTGCCAACCCTAATGAATATGGCTGCATCCTTTGATATCCCCAAGGA AAAGAGACTGCGAGCCAGTGCAGCCTTGAACTGTTTAAAACGCTTCCATGAAATGAAGAAACGAGGACCTAAGCCTTATAGTCTTCATTT AGACCACATTATTCAGAAAGCAATTGCAACACACCAGAAACGGGATCAGTATCTCCGAGTTCAGAAAGATATATTTATCCTTAAGGATAC AGAGGAAGCTCTTTTAATTAACCTTAGAGATAGCCAAGTCCTTCAACATAAAGAGAATCTTGAATGGAATTGGAATCTTATAGGGACCAT TCTTAAGTGGCCAAATGTAAATCTAAGAAACTATAAAGATGAACAGTTACACAGGTTTGTACGAAGACTACTTTATTTTTACAAGCCCAG CAGTAAATTATATGCCAACCTGGATCTGGATTTTGCCAAGGCCAAACAGCTCACGGTTGTAGGTTGCCAGTTTACAGAATTTCTTCTTGA ATCTGAAGAGGATGGGCAAGGCTACTTAGAAGATCTAGTAAAGGATATTGTTCAGTGGCTCAATGCTTCATCTGGAATGAAACCCGAAAG AAGTCTTCAAAATAATGGTTTATTGACCACCCTTAGTCAACACTACTTTTTATTTATTGGAACACTTTCTTGCCACCCTCATGGAGTTAA AATGCTGGAAAAATGCAGTGTATTTCAGTGTCTCCTTAATCTTTGCTCCTTGAAAAACCAAGATCACTTGCTAAAACTTACTGTTTCTAG CTTGGACTATAGCAGAGATGGATTGGCTAGAGTCATCCTTTCCAAAATTTTAACTGCAGCTACTGATGCCTGCAGACTCTATGCAACAAA ACATTTAAGGGTATTATTGAGAGCTAATGTTGAATTCTTTAATAATTGGGGAATTGAGTTGTTAGTGACCCAGCTACATGATAAAAACAA AACGATTTCCTCTGAAGCTCTTGATATCCTCGATGAAGCATGTGAAGACAAGGCCAATCTTCATGCTCTCATTCAGATGAAACCAGCGTT ATCCCACCTTGGAGACAAGGGTTTGCTTCTCCTGCTGAGATTTCTCTCCATTCCAAAAGGATTTTCCTATCTGAATGAAAGAGGTTATGT AGCAAAACAATTGGAAAAGTGGCACAGGGAATACAACTCCAAATATGTTGACTTGATTGAGGAACAACTCAATGAAGCACTTACTACTTA CCGGAAGCCTGTTGATGGTGATAACTATGTTCGTCGGAGTAACCAAAGATTACAGCGTCCTCACGTCTACCTGCCTATACACCTTTATGG ACAACTAGTACACCATAAAACAGGCTGCCATTTGTTGGAAGTACAGAATATTATTACAGAACTCTGTCGTAATGTTCGTACACCAGATTT GGATAAGTGGGAAGAAATTAAAAAACTGAAAGCATCTCTTTGGGCCTTGGGAAATATCGGCTCATCAAATTGGGGTCTCAATTTGCTACA GGAAGAAAACGTGATTCCAGATATACTAAAACTTGCAAAACAGTGTGAAGTTCTTTCCATCAGAGGGACCTGTGTATATGTACTTGGGCT CATAGCTAAAACCAAACAAGGCTGTGATATTCTAAAATGTCACAACTGGGATGCTGTGAGGCATAGTCGCAAACATCTGTGGCCAGTGGT TCCAGATGATGTGGAACAACTCTGTAATGAACTTTCATCTATCCCAAGCACTCTAAGTTTGAACTCGGAGTCAACCAGCTCTAGACATAA TAGTGAAAGTGAATCTGTGCCATCGAGTATGTTCATATTGGAGGATGACCGGTTTGGCAGCAGCTCTACTAGCACATTTTTCCTTGATAT CAATGAAGATACAGAGCCAACATTTTATGACCGATCTGGACCCATAAAGGATAAAAATTCATTCCCTTTCTTTGCTTCTAGTAAACTTGT GAAGAATCGTATCTTAAATTCGCTTACTTTGCCTAACAAAAAACATCGTAGTAGCAGTGATCCAAAAGGAGGGAAATTATCATCTGAAAG TAAGACAAGCAACAGGCGAATCAGAACACTTACGGAGCCCAGTGTTGATTTTAATCATAGTGATGATTTTACACCCATATCCACTGTACA GAAAACATTACAATTAGAGACTTCATTTATGGGGAATAAGCACATTGAAGACACTGGTAGTACACCAAGCATTGGAGAAAATGACTTAAA ATTCACCAAGAATTTTGGTACAGAGAATCACAGAGAAAATACAAGCCGAGAGAGGTTAGTAGTAGAAAGTTCAACGAGCTCACATATGAA GATACGTAGCCAAAGTTTCAATACAGACACTACAACAAGTGGCATAAGTTCAATGAGCTCAAGTCCTTCACGAGAGACAGTAGGTGTAGA TGCTACAACTATGGACACAGACTGTGGAAGCATGAGTACTGTGGTAAGTACTAAAACTATTAAGACAAGCCACTATTTGACGCCACAGTC TAACCATCTGTCTCTCTCCAAATCAAATTCGGTGTCCCTGGTGCCTCCAGGTTCTTCTCATACGCTTCCTAGAAGAGCACAGTCCCTTAA AGCACCCTCTATTGCTACAATTAAAAGTCTAGCAGATTGTAACTTTAGTTACACAAGTTCTAGAGATGCTTTTGGCTATGCTACACTGAA AAGACTACAGCAACAAAGAATGCATCCATCCTTATCTCACTCTGAAGCTTTGGCATCTCCAGCAAAAGATGTGCTATTTACTGATACCAT CACCATGAAGGCCAACAGTTTTGAGTCCAGATTAACACCAAGCAGGATCGATTTTAAAAAGAAGCATGTCGGGGGAATCAGGAGCTTAAG ACCTACAATAACAAACAACCTTTTCAGGTTCATGAAAGCCTTAAGTTATGCATCATTAGATAAAGAAGATTTATTGAGTCCTATTAATCA AAATACCCTGCAACGATCTTCCTCAGTGCGGTCCATGGTGTCCAGTGCCACATATGGGGGTTCAGATGATTACATTGGTCTTGCTCTCCC GGTGGATATAAATGATATATTCCAGGTAAAGGATATTCCCTATTTTCAGACAAAAAACATACCACCACATGATGATCGAGGTGCAAGAGC ATTTGCCCATGATGCAGGAGGTCTTCCATCTGGAACTGGAGGTCTTGTAAAAAATTCTTTTCACTTGCTACGACAGCAGATGAGTCTTAC GGAAATAATGAATTCAATCCATTCAGATGCCTCTCTGTTTTTAGAAAGTACAGAAGACACTGGACTACAGGAACATACAGATGATAACTG CCTTTATTGTGTCTGTATTGAAATTCTGGGTTTCCAGCCCAGCAACCAACTGAGTGCAATATGTAGTCATTCAGACTTTCAAGATATTCC ATATTCTGATTGGTGTGAGCAGACTATCCATAATCCTTTAGAAGTGGTTCCCTCTAAGTTTTCGGGGATTTCTGGATGCAGTGATGGGGT GTCTCAAGAAGGCTCAGCTAGCAGCACCAAAAGCACAGAATTGTTACTAGGTGTTAAAACAATTCCAGATGATACACCAATGTGCCGTAT ACTCCTTCGCAAAGAAGTTCTAAGATTAGTCATTAATTTGAGTAGTTCAGTTTCAACTAAATGTCATGAGACTGGGCTTTTAACAATTAA GGAGAAGTATCCTCAAACATTTGATGACATATGCCTTTACTCTGAGGTTTCCCATTTGCTGTCACACTGCACATTCAGACTTCCGTGTCG GAGGTTCATACAAGAATTATTTCAAGATGTACAGTTTCTACAAATGCATGAAGAAGCAGAGGCTGTGTTGGCAACACCACCAAAGCAACC TATAGTTGATACATCTGCTGAATCCTGACCTCATATTTATGATGGATATAGATACATACTATATATATTCATATTTGTGGATTTCCTAAA AGCCTCAGAAAATACGACTGACTAGGCAGCAAAGACAGGAGTATCTTCTGTACACTGTTCCGCAGTTACTGGTACATGAACAGTTGGAAC TGCTGACTTTCCTAACCAAAACAACTTCCTTCTCTCCTTTGTTGAGCCTTTTGAGGGGTTCATGATTCATTACCACAGTTTTAAGAGTTT CAGTTACCATTGTATGCAAGAGCCAAGCACTGAATACCTACATAGGTTTTCTATTTTCTTTCATTTTAAAAGCATAATGACAGTGGAACA ATAATGGGATATGCAGAAGCACCCTTCACAAGTTATTTCTGAATGATTTTTAGGGTAAATAATACAGATGCCTTGTTTGTTAACTAACTT GTGGAAAGCAGGAATCAGTGTCTCTAAGGCTGCATCCTATTACCACAATGGGGTGTGCTATAACTGCTGGTATTAGAGAGGGAACTTTGG CCCTTTCACGTTTTTCTTAATGTTTGTAACACTACTTCAGAGGTTTATAACCTCAAAGCAGAAGAAGAGCCTCAACAACCCGGGACTTAT AAGTTATTTTTATGTTACTAGACTTGCATAAAGATTCTTGTTTTCCAACTCTTCATTTTGTTGCAATGTGTTATTACAGGATATATGAAC CAATTAAGGTTTTTCACTACAGTTCTTGAATAAAATTTAAAAATCATTTTTTATTTTAATTAAAAATATTTCCCATTTATAGAATGCATA TATTTGCAATGGACTTCCACTTTCATCAACTTTCCATCTCATCGCTTTAAACAGGAACTTGAACAAGCACTGTTAGTTTAGACCTAAAGG ATAGGAAAGCATTAAATAATACTTTGGATCTCCTGAGGAAAAGATAAGTTTGCTTGCAATTTACACATTCCATGGGGAAAGAAGAGCCAT ATTTCCTTAAAAAAAACATTAATAAAGCTTGTTATTGAGAAAAATTGTAGTGAAAAGCCTTAAGTACCAAATTTTAAAGCAGCAGTAACT TAATTTTTATATCAGTGTTTTTGTTTTGCACAAACTAAATGCAGTGGTAGGTGGGTTTATGAGTATATTAATTGCCTTTATCCATTTGTG AAGTTAAGTTGATGAGGGCAAGGTTTTTGTTTGTTTAATTTGTATATGTCTAAAGGTATTTGGAACTTTTTACAGGAATTAAACATATAT GCAAATTTGTATATAAAAATAGCATGGCCATCATTTGAATGCTTGTAAATGAAAGGATTATCTTTTTTGAGATCTATATATAAATAGAAA TAGAAAATCCAGCTGGACTGATTAGGATTCTTTTTTAATTCATTTGTGTATAACATTTTTATTACAATTACACATCAGTTTTGACACAGT CATAGCAACATTAATATTTTCCCATGATGCAGATCCTTTTTGTAATGGGCTTGTTCTTTGAGATCTCTGTAAAGAACCCTGTGAACTAGA AAACATAACTCACAGAGATACTTTTTTAAAAAATTTATTTACTGGAACTGAAAGTTCCAGTTGGGATGAAGCATTTCATCTCACTTCATA ACACCTCTTTGACTGCACTTCAGTGAATTGTTCTTATGTGCACTGTGTAGCAACTTACATTATAACAAAGCAGATAAGGGCTGTAAGCTG CTGCTTATGTTGAAAAGTGGTTCTTCAGATTTTCTCTCATAAAATCCAGTTGAAGATAAATAATTTTTTTATACTTTATCACTGAACCCA AGTGTTTATTTAAATGTCAACAGTACTTCTAAGAACGTTGCCTGTCATCGTGGTCTTTGGTCTTGGATAACTAAACTGCCTTTCCAGAGA ACCAAATGTCAGAGTTACTAGACCAAATAGTGGTTAAAACCTCCAAAGGAAGTAATGTAATCTTATTCATAATGGGATTAACATATTTTA GACATTCATTTTAAACACTACCTCAGTTAATATAGAGTATAAAAATCTGTGGTTTAATCCCTCAAAAGTTAACAGTAATTTTTTTTTTGT CTTACACACACACACACCCCCTCCCCCACCATCACTATCCCTGTACCCTCACCTTGGTCATCTATCCTGAAATAAGGCTTAGTTAGTATT GGCCTGAATGTTTTGTGTTTTTTTTTTTGTTTTTTTTTTTTACTGTTACTTTGAAAAATATGTATGTATACCTTATCATATCTGCCTATA TCACTTACTTTGGGGAGATACTCAGAGCTTTGTGGTTATCAGTATACTAAAAAAAAAAAAAA >98629_98629_1_VWA8-RICTOR_VWA8_chr13_42534989_ENST00000281496_RICTOR_chr5_38964994_ENST00000296782_length(amino acids)=1374AA_BP=75 MHGTPLDPRAPSPSPTAPPAPCNPGFYSSGHPEATAARPRGACGCSCGRWCSAGRVATGSGRRSDCCTPARGPTQANTILPHSHSHHLHC LPTLMNMAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQKAIATHQKRDQYLRVQKDIFILKDTEEALLINLRDSQVL QHKENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYANLDLDFAKAKQLTVVGCQFTEFLLESEEDGQGYLEDLVK DIVQWLNASSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILS KILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRF LSIPKGFSYLNERGYVAKQLEKWHREYNSKYVDLIEEQLNEALTTYRKPVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEV QNIITELCRNVRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCH NWDAVRHSRKHLWPVVPDDVEQLCNELSSIPSTLSLNSESTSSRHNSESESVPSSMFILEDDRFGSSSTSTFFLDINEDTEPTFYDRSGP IKDKNSFPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTPISTVQKTLQLETSFMGNKH IEDTGSTPSIGENDLKFTKNFGTENHRENTSRERLVVESSTSSHMKIRSQSFNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMSTV VSTKTIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHS EALASPAKDVLFTDTITMKANSFESRLTPSRIDFKKKHVGGIRSLRPTITNNLFRFMKALSYASLDKEDLLSPINQNTLQRSSSVRSMVS SATYGGSDDYIGLALPVDINDIFQVKDIPYFQTKNIPPHDDRGARAFAHDAGGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDASLFL ESTEDTGLQEHTDDNCLYCVCIEILGFQPSNQLSAICSHSDFQDIPYSDWCEQTIHNPLEVVPSKFSGISGCSDGVSQEGSASSTKSTEL LLGVKTIPDDTPMCRILLRKEVLRLVINLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDVQFLQ MHEEAEAVLATPPKQPIVDTSAES -------------------------------------------------------------- >98629_98629_2_VWA8-RICTOR_VWA8_chr13_42534989_ENST00000281496_RICTOR_chr5_38964994_ENST00000357387_length(transcript)=8481nt_BP=268nt AGGTGCCGCTTCCTGTCCCCTTCTCCGCGCTGCCTCACGGTGCCTGCACGGGACGCCGCTCGATCCCCGAGCCCCCTCGCCGTCCCCGAC AGCCCCCCCGGCGCCATGCAATCCCGGCTTCTACTCCTCGGGGCACCCGGAGGCCACGGCGGCCCGGCCTCGCGGCGCATGCGGCTGCTC CTGCGGCAGGTGGTGCAGCGCAGGCCGGGTGGCGACAGGCAGCGGCCGGAGGTCAGACTGTTGCACGCCGGCTCGGGGGCCGACACAGGC AAACACAATTCTTCCTCATTCACATAGCCATCATTTACACTGCTTGCCAACCCTAATGAATATGGCTGCATCCTTTGATATCCCCAAGGA AAAGAGACTGCGAGCCAGTGCAGCCTTGAACTGTTTAAAACGCTTCCATGAAATGAAGAAACGAGGACCTAAGCCTTATAGTCTTCATTT AGACCACATTATTCAGAAAGCAATTGCAACACACCAGAAACGGGATCAGTATCTCCGAGTTCAGAAAGATATATTTATCCTTAAGGATAC AGAGGAAGCTCTTTTAATTAACCTTAGAGATAGCCAAGTCCTTCAACATAAAGAGAATCTTGAATGGAATTGGAATCTTATAGGGACCAT TCTTAAGTGGCCAAATGTAAATCTAAGAAACTATAAAGATGAACAGTTACACAGGTTTGTACGAAGACTACTTTATTTTTACAAGCCCAG CAGTAAATTATATGCCAACCTGGATCTGGATTTTGCCAAGGCCAAACAGCTCACGGTTGTAGGTTGCCAGTTTACAGAATTTCTTCTTGA ATCTGAAGAGGATGGGCAAGGCTACTTAGAAGATCTAGTAAAGGATATTGTTCAGTGGCTCAATGCTTCATCTGGAATGAAACCCGAAAG AAGTCTTCAAAATAATGGTTTATTGACCACCCTTAGTCAACACTACTTTTTATTTATTGGAACACTTTCTTGCCACCCTCATGGAGTTAA AATGCTGGAAAAATGCAGTGTATTTCAGTGTCTCCTTAATCTTTGCTCCTTGAAAAACCAAGATCACTTGCTAAAACTTACTGTTTCTAG CTTGGACTATAGCAGAGATGGATTGGCTAGAGTCATCCTTTCCAAAATTTTAACTGCAGCTACTGATGCCTGCAGACTCTATGCAACAAA ACATTTAAGGGTATTATTGAGAGCTAATGTTGAATTCTTTAATAATTGGGGAATTGAGTTGTTAGTGACCCAGCTACATGATAAAAACAA AACGATTTCCTCTGAAGCTCTTGATATCCTCGATGAAGCATGTGAAGACAAGGCCAATCTTCATGCTCTCATTCAGATGAAACCAGCGTT ATCCCACCTTGGAGACAAGGGTTTGCTTCTCCTGCTGAGATTTCTCTCCATTCCAAAAGGATTTTCCTATCTGAATGAAAGAGGTTATGT AGCAAAACAATTGGAAAAGTGGCACAGGGAATACAACTCCAAATATGTTGACTTGATTGAGGAACAACTCAATGAAGCACTTACTACTTA CCGGAAGCCTGTTGATGGTGATAACTATGTTCGTCGGAGTAACCAAAGATTACAGCGTCCTCACGTCTACCTGCCTATACACCTTTATGG ACAACTAGTACACCATAAAACAGGCTGCCATTTGTTGGAAGTACAGAATATTATTACAGAACTCTGTCGTAATGTTCGTACACCAGATTT GGATAAGTGGGAAGAAATTAAAAAACTGAAAGCATCTCTTTGGGCCTTGGGAAATATCGGCTCATCAAATTGGGGTCTCAATTTGCTACA GGAAGAAAACGTGATTCCAGATATACTAAAACTTGCAAAACAGTGTGAAGTTCTTTCCATCAGAGGGACCTGTGTATATGTACTTGGGCT CATAGCTAAAACCAAACAAGGCTGTGATATTCTAAAATGTCACAACTGGGATGCTGTGAGGCATAGTCGCAAACATCTGTGGCCAGTGGT TCCAGATGATGTGGAACAACTCTGTAATGAACTTTCATCTATCCCAAGCACTCTAAGTTTGAACTCGGAGTCAACCAGCTCTAGACATAA TAGTGAAAGTGAATCTGTGCCATCGAGTATGTTCATATTGGAGGATGACCGGTTTGGCAGCAGCTCTACTAGCACATTTTTCCTTGATAT CAATGAAGATACAGAGCCAACATTTTATGACCGATCTGGACCCATAAAGGATAAAAATTCATTCCCTTTCTTTGCTTCTAGTAAACTTGT GAAGAATCGTATCTTAAATTCGCTTACTTTGCCTAACAAAAAACATCGTAGTAGCAGTGATCCAAAAGGAGGGAAATTATCATCTGAAAG TAAGACAAGCAACAGGCGAATCAGAACACTTACGGAGCCCAGTGTTGATTTTAATCATAGTGATGATTTTACACCCATATCCACTGTACA GAAAACATTACAATTAGAGACTTCATTTATGGGGAATAAGCACATTGAAGACACTGGTAGTACACCAAGCATTGGAGAAAATGACTTAAA ATTCACCAAGAATTTTGGTACAGAGAATCACAGAGAAAATACAAGCCGAGAGAGGTTAGTAGTAGAAAGTTCAACGAGCTCACATATGAA GATACGTAGCCAAAGTTTCAATACAGACACTACAACAAGTGGCATAAGTTCAATGAGCTCAAGTCCTTCACGAGAGACAGTAGGTGTAGA TGCTACAACTATGGACACAGACTGTGGAAGCATGAGTACTGTGGTAAGTACTAAAACTATTAAGACAAGCCACTATTTGACGCCACAGTC TAACCATCTGTCTCTCTCCAAATCAAATTCGGTGTCCCTGGTGCCTCCAGGTTCTTCTCATACGCTTCCTAGAAGAGCACAGTCCCTTAA AGCACCCTCTATTGCTACAATTAAAAGTCTAGCAGATTGTAACTTTAGTTACACAAGTTCTAGAGATGCTTTTGGCTATGCTACACTGAA AAGACTACAGCAACAAAGAATGCATCCATCCTTATCTCACTCTGAAGCTTTGGCATCTCCAGCAAAAGATGTGCTATTTACTGATACCAT CACCATGAAGGCCAACAGTTTTGAGTCCAGATTAACACCAAGCAGGTTCATGAAAGCCTTAAGTTATGCATCATTAGATAAAGAAGATTT ATTGAGTCCTATTAATCAAAATACCCTGCAACGATCTTCCTCAGTGCGGTCCATGGTGTCCAGTGCCACATATGGGGGTTCAGATGATTA CATTGGTCTTGCTCTCCCGGTGGATATAAATGATATATTCCAGGTAAAGGATATTCCCTATTTTCAGACAAAAAACATACCACCACATGA TGATCGAGGTGCAAGAGCATTTGCCCATGATGCAGGAGGTCTTCCATCTGGAACTGGAGGTCTTGTAAAAAATTCTTTTCACTTGCTACG ACAGCAGATGAGTCTTACGGAAATAATGAATTCAATCCATTCAGATGCCTCTCTGTTTTTAGAAAGTACAGAAGACACTGGACTACAGGA ACATACAGATGATAACTGCCTTTATTGTGTCTGTATTGAAATTCTGGGTTTCCAGCCCAGCAACCAACTGAGTGCAATATGTAGTCATTC AGACTTTCAAGATATTCCATATTCTGATTGGTGTGAGCAGACTATCCATAATCCTTTAGAAGTGGTTCCCTCTAAGTTTTCGGGGATTTC TGGATGCAGTGATGGGGTGTCTCAAGAAGGCTCAGCTAGCAGCACCAAAAGCACAGAATTGTTACTAGGTGTTAAAACAATTCCAGATGA TACACCAATGTGCCGTATACTCCTTCGCAAAGAAGTTCTAAGATTAGTCATTAATTTGAGTAGTTCAGTTTCAACTAAATGTCATGAGAC TGGGCTTTTAACAATTAAGGAGAAGTATCCTCAAACATTTGATGACATATGCCTTTACTCTGAGGTTTCCCATTTGCTGTCACACTGCAC ATTCAGACTTCCGTGTCGGAGGTTCATACAAGAATTATTTCAAGATGTACAGTTTCTACAAATGCATGAAGAAGCAGAGGCTGTGTTGGC AACACCACCAAAGCAACCTATAGTTGATACATCTGCTGAATCCTGACCTCATATTTATGATGGATATAGATACATACTATATATATTCAT ATTTGTGGATTTCCTAAAAGCCTCAGAAAATACGACTGACTAGGCAGCAAAGACAGGAGTATCTTCTGTACACTGTTCCGCAGTTACTGG TACATGAACAGTTGGAACTGCTGACTTTCCTAACCAAAACAACTTCCTTCTCTCCTTTGTTGAGCCTTTTGAGGGGTTCATGATTCATTA CCACAGTTTTAAGAGTTTCAGTTACCATTGTATGCAAGAGCCAAGCACTGAATACCTACATAGGTTTTCTATTTTCTTTCATTTTAAAAG CATAATGACAGTGGAACAATAATGGGATATGCAGAAGCACCCTTCACAAGTTATTTCTGAATGATTTTTAGGGTAAATAATACAGATGCC TTGTTTGTTAACTAACTTGTGGAAAGCAGGAATCAGTGTCTCTAAGGCTGCATCCTATTACCACAATGGGGTGTGCTATAACTGCTGGTA TTAGAGAGGGAACTTTGGCCCTTTCACGTTTTTCTTAATGTTTGTAACACTACTTCAGAGGTTTATAACCTCAAAGCAGAAGAAGAGCCT CAACAACCCGGGACTTATAAGTTATTTTTATGTTACTAGACTTGCATAAAGATTCTTGTTTTCCAACTCTTCATTTTGTTGCAATGTGTT ATTACAGGATATATGAACCAATTAAGGTTTTTCACTACAGTTCTTGAATAAAATTTAAAAATCATTTTTTATTTTAATTAAAAATATTTC CCATTTATAGAATGCATATATTTGCAATGGACTTCCACTTTCATCAACTTTCCATCTCATCGCTTTAAACAGGAACTTGAACAAGCACTG TTAGTTTAGACCTAAAGGATAGGAAAGCATTAAATAATACTTTGGATCTCCTGAGGAAAAGATAAGTTTGCTTGCAATTTACACATTCCA TGGGGAAAGAAGAGCCATATTTCCTTAAAAAAAACATTAATAAAGCTTGTTATTGAGAAAAATTGTAGTGAAAAGCCTTAAGTACCAAAT TTTAAAGCAGCAGTAACTTAATTTTTATATCAGTGTTTTTGTTTTGCACAAACTAAATGCAGTGGTAGGTGGGTTTATGAGTATATTAAT TGCCTTTATCCATTTGTGAAGTTAAGTTGATGAGGGCAAGGTTTTTGTTTGTTTAATTTGTATATGTCTAAAGGTATTTGGAACTTTTTA CAGGAATTAAACATATATGCAAATTTGTATATAAAAATAGCATGGCCATCATTTGAATGCTTGTAAATGAAAGGATTATCTTTTTTGAGA TCTATATATAAATAGAAATAGAAAATCCAGCTGGACTGATTAGGATTCTTTTTTAATTCATTTGTGTATAACATTTTTATTACAATTACA CATCAGTTTTGACACAGTCATAGCAACATTAATATTTTCCCATGATGCAGATCCTTTTTGTAATGGGCTTGTTCTTTGAGATCTCTGTAA AGAACCCTGTGAACTAGAAAACATAACTCACAGAGATACTTTTTTAAAAAATTTATTTACTGGAACTGAAAGTTCCAGTTGGGATGAAGC ATTTCATCTCACTTCATAACACCTCTTTGACTGCACTTCAGTGAATTGTTCTTATGTGCACTGTGTAGCAACTTACATTATAACAAAGCA GATAAGGGCTGTAAGCTGCTGCTTATGTTGAAAAGTGGTTCTTCAGATTTTCTCTCATAAAATCCAGTTGAAGATAAATAATTTTTTTAT ACTTTATCACTGAACCCAAGTGTTTATTTAAATGTCAACAGTACTTCTAAGAACGTTGCCTGTCATCGTGGTCTTTGGTCTTGGATAACT AAACTGCCTTTCCAGAGAACCAAATGTCAGAGTTACTAGACCAAATAGTGGTTAAAACCTCCAAAGGAAGTAATGTAATCTTATTCATAA TGGGATTAACATATTTTAGACATTCATTTTAAACACTACCTCAGTTAATATAGAGTATAAAAATCTGTGGTTTAATCCCTCAAAAGTTAA CAGTAATTTTTTTTTTGTCTTACACACACACACACCCCCTCCCCCACCATCACTATCCCTGTACCCTCACCTTGGTCATCTATCCTGAAA TAAGGCTTAGTTAGTATTGGCCTGAATGTTTTGTGTTTTTTTTTTTGTTTTTTTTTTTTACTGTTACTTTGAAAAATATGTATGTATACC TTATCATATCTGCCTATATCACTTACTTTGGGGAGATACTCAGAGCTTTGTGGTTATCAGTATACTAAAAAAAAAAAAAAGTCTACGCTT AAATTTATAGTGCTATTTGGTTTCTCCATGATTTCACTGACAGGTCTAATACATTTTCTTTGAGTACTTGTTTGTAAAAAGTAGACTTTA TGGTGAAAAATACATGCAGTGCCAAGTGATTAACTTAAGTGTTTAAAAATATTAAATTATAGCAGAAGAGGTTAGGAATGATATCAGCAG TAATAGAAATAATTGAGAAAATCATCTATAAATAATAGATATTACAGACTATAGAATACCAAAATAATGTCAATACTGTAGTTTTTAAAG ATTTTAGGATTAATCTTAGTCCATATAAATTTGTACTATTGGTAATTATTGAATAATTGGGAGGAATCTGGGCAGTTGTGCTGGTTGTAA ACTATGAATTTCTAATCGTAAAGTGAATTGTTATTTCTAATTGAACTTTTTTTCAAGAACAGATTTCAGCCTCACATACTAAGTAAATAC TGATAAATAAGGAAATTAGAAATTTAGTATTCATAATTAAATATGCTCTAAAATTTCCTATACTTTTATTTCCTGTTTATTCTTAGGTAG ATTGGAAGGGGGAAACAGTCTGTTCTCCCTAATTAAATTTTTTCTAATAACGATTAGTAGAATATGGACATTCTATATGACAGTGACATT AAAAGAGGCTCTTTGGAAGTATATACATTATTAACATAATGTGTACAAGTCCTTTTGAAATGACAACTTTAATGGGTTTCAGCTCTTTTA TCTAGAGCTTGAGATAATTCAAGCTGAGTTTTTCAGGGCATATCACAACGGCCAAGTGTTCAGCAGTGGGATATCAATGCTTATTTACAT TTTCCTACTGCTATTTATATAAAATGTTATTCCATTCAGAGGATGCCTTTTATCCCCACATTAAAGCACAGATCATTAAGCAATAAAAAC CAAATTGTCTGTCATTCAAATTATAACTGCAGTTATTTTTGCATGGTAAGAGTGAGGTGCTAATTTTGTGTGAGATGAACTTTGTAAACT ACTTTGGGAAATGTTCTTTGGAAGTAAGGTTTTTTCTCCTTTAGTCTTATGCTTCCACTTTTGTCTCAGATTCACAATCCATTAAAACAT GGGGAAAAAAGAAAAGGTAAAATTGAGAGACTTTTGTTAGAGGAGCTATTTGGAATGAACCAACATTTCAGATTTTCCAAAATGTAAGTT AGGAAGTCTCCATTGTCTCTGCATTAACAAAATACACTGTTACTATCTTAATCTCAAGAGTGTCATTACAGTGAGAATCTCATTTAAAAG CATACCAGTGAAATTAATAGCAGTGCTTATCAAAGAACACTGAAATCTGTGAGAATCTTTCTAGGAGCATTCTTTTCTTCTTTTAGTTCC AAGTTCCAGGGTATTTTTCATTCCTAGTAGGTTTATATGACTCACAGAATGTGGACTTTTTTCCTGTTTGGAGTATTTTTGTAATGTAAG TATCGGATAGCTGCACCACAGCATGCATAAATTGCACATTTTGTTTTACTTTCTTTATAGAATATTTAATTTCAAAAATATAATTTATGC CAAAAAAAGCATACCTTTCAATTTTGCTACTTGGTTGATTTAGCACAAAATGCAAAGTCTTGGGGCAGAGAGGGGGAGTGAAAAAAATTT TATAGGTAATTGTTACAAAAATACCTGTCAGAAACCCTAAAGCTGCATTGTAAAACAAATGGTGTAAACTAGTTTTGAAAAGTGGTAAGG AATTGTGAAAAAAATCTCAGACTTAATGCTCTCTAACCACATGAGTTTCTTCTTTTTTATTTAGTAATACGCTGCTACATATTTGGAGGT TCTGGTGTTTGTAGGTCACTGAACAGACATTGAAATCTGATTTATATTGTATAACTGTAACATAGAAAGAAAAAGTATTTATATTTTTTC TGTAAGAATATTTCATTGAGTTGTGTATAATTTAAATAAGATTTGTCCCCAAATGGTTTTGCTCACCTTGATTTTTTTTGTTGTGATTTT CTTGTTTTTGTATAATGTGTATAGTTTATGTCAAGGGCATTAAAAGCCTCCTGAAGCATAATCTTATCAAAGGGATACATTGTTAATAAA ATGTACTTAAAATTCTTAAAC >98629_98629_2_VWA8-RICTOR_VWA8_chr13_42534989_ENST00000281496_RICTOR_chr5_38964994_ENST00000357387_length(amino acids)=1350AA_BP=75 MHGTPLDPRAPSPSPTAPPAPCNPGFYSSGHPEATAARPRGACGCSCGRWCSAGRVATGSGRRSDCCTPARGPTQANTILPHSHSHHLHC LPTLMNMAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQKAIATHQKRDQYLRVQKDIFILKDTEEALLINLRDSQVL QHKENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYANLDLDFAKAKQLTVVGCQFTEFLLESEEDGQGYLEDLVK DIVQWLNASSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILS KILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRF LSIPKGFSYLNERGYVAKQLEKWHREYNSKYVDLIEEQLNEALTTYRKPVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEV QNIITELCRNVRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCH NWDAVRHSRKHLWPVVPDDVEQLCNELSSIPSTLSLNSESTSSRHNSESESVPSSMFILEDDRFGSSSTSTFFLDINEDTEPTFYDRSGP IKDKNSFPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTPISTVQKTLQLETSFMGNKH IEDTGSTPSIGENDLKFTKNFGTENHRENTSRERLVVESSTSSHMKIRSQSFNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMSTV VSTKTIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHS EALASPAKDVLFTDTITMKANSFESRLTPSRFMKALSYASLDKEDLLSPINQNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQ VKDIPYFQTKNIPPHDDRGARAFAHDAGGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDASLFLESTEDTGLQEHTDDNCLYCVCIEI LGFQPSNQLSAICSHSDFQDIPYSDWCEQTIHNPLEVVPSKFSGISGCSDGVSQEGSASSTKSTELLLGVKTIPDDTPMCRILLRKEVLR LVINLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDVQFLQMHEEAEAVLATPPKQPIVDTSAES -------------------------------------------------------------- >98629_98629_3_VWA8-RICTOR_VWA8_chr13_42534989_ENST00000379310_RICTOR_chr5_38964994_ENST00000296782_length(transcript)=6416nt_BP=232nt ACGGTGCCTGCACGGGACGCCGCTCGATCCCCGAGCCCCCTCGCCGTCCCCGACAGCCCCCCCGGCGCCATGCAATCCCGGCTTCTACTC CTCGGGGCACCCGGAGGCCACGGCGGCCCGGCCTCGCGGCGCATGCGGCTGCTCCTGCGGCAGGTGGTGCAGCGCAGGCCGGGTGGCGAC AGGCAGCGGCCGGAGGTCAGACTGTTGCACGCCGGCTCGGGGGCCGACACAGGCAAACACAATTCTTCCTCATTCACATAGCCATCATTT ACACTGCTTGCCAACCCTAATGAATATGGCTGCATCCTTTGATATCCCCAAGGAAAAGAGACTGCGAGCCAGTGCAGCCTTGAACTGTTT AAAACGCTTCCATGAAATGAAGAAACGAGGACCTAAGCCTTATAGTCTTCATTTAGACCACATTATTCAGAAAGCAATTGCAACACACCA GAAACGGGATCAGTATCTCCGAGTTCAGAAAGATATATTTATCCTTAAGGATACAGAGGAAGCTCTTTTAATTAACCTTAGAGATAGCCA AGTCCTTCAACATAAAGAGAATCTTGAATGGAATTGGAATCTTATAGGGACCATTCTTAAGTGGCCAAATGTAAATCTAAGAAACTATAA AGATGAACAGTTACACAGGTTTGTACGAAGACTACTTTATTTTTACAAGCCCAGCAGTAAATTATATGCCAACCTGGATCTGGATTTTGC CAAGGCCAAACAGCTCACGGTTGTAGGTTGCCAGTTTACAGAATTTCTTCTTGAATCTGAAGAGGATGGGCAAGGCTACTTAGAAGATCT AGTAAAGGATATTGTTCAGTGGCTCAATGCTTCATCTGGAATGAAACCCGAAAGAAGTCTTCAAAATAATGGTTTATTGACCACCCTTAG TCAACACTACTTTTTATTTATTGGAACACTTTCTTGCCACCCTCATGGAGTTAAAATGCTGGAAAAATGCAGTGTATTTCAGTGTCTCCT TAATCTTTGCTCCTTGAAAAACCAAGATCACTTGCTAAAACTTACTGTTTCTAGCTTGGACTATAGCAGAGATGGATTGGCTAGAGTCAT CCTTTCCAAAATTTTAACTGCAGCTACTGATGCCTGCAGACTCTATGCAACAAAACATTTAAGGGTATTATTGAGAGCTAATGTTGAATT CTTTAATAATTGGGGAATTGAGTTGTTAGTGACCCAGCTACATGATAAAAACAAAACGATTTCCTCTGAAGCTCTTGATATCCTCGATGA AGCATGTGAAGACAAGGCCAATCTTCATGCTCTCATTCAGATGAAACCAGCGTTATCCCACCTTGGAGACAAGGGTTTGCTTCTCCTGCT GAGATTTCTCTCCATTCCAAAAGGATTTTCCTATCTGAATGAAAGAGGTTATGTAGCAAAACAATTGGAAAAGTGGCACAGGGAATACAA CTCCAAATATGTTGACTTGATTGAGGAACAACTCAATGAAGCACTTACTACTTACCGGAAGCCTGTTGATGGTGATAACTATGTTCGTCG GAGTAACCAAAGATTACAGCGTCCTCACGTCTACCTGCCTATACACCTTTATGGACAACTAGTACACCATAAAACAGGCTGCCATTTGTT GGAAGTACAGAATATTATTACAGAACTCTGTCGTAATGTTCGTACACCAGATTTGGATAAGTGGGAAGAAATTAAAAAACTGAAAGCATC TCTTTGGGCCTTGGGAAATATCGGCTCATCAAATTGGGGTCTCAATTTGCTACAGGAAGAAAACGTGATTCCAGATATACTAAAACTTGC AAAACAGTGTGAAGTTCTTTCCATCAGAGGGACCTGTGTATATGTACTTGGGCTCATAGCTAAAACCAAACAAGGCTGTGATATTCTAAA ATGTCACAACTGGGATGCTGTGAGGCATAGTCGCAAACATCTGTGGCCAGTGGTTCCAGATGATGTGGAACAACTCTGTAATGAACTTTC ATCTATCCCAAGCACTCTAAGTTTGAACTCGGAGTCAACCAGCTCTAGACATAATAGTGAAAGTGAATCTGTGCCATCGAGTATGTTCAT ATTGGAGGATGACCGGTTTGGCAGCAGCTCTACTAGCACATTTTTCCTTGATATCAATGAAGATACAGAGCCAACATTTTATGACCGATC TGGACCCATAAAGGATAAAAATTCATTCCCTTTCTTTGCTTCTAGTAAACTTGTGAAGAATCGTATCTTAAATTCGCTTACTTTGCCTAA CAAAAAACATCGTAGTAGCAGTGATCCAAAAGGAGGGAAATTATCATCTGAAAGTAAGACAAGCAACAGGCGAATCAGAACACTTACGGA GCCCAGTGTTGATTTTAATCATAGTGATGATTTTACACCCATATCCACTGTACAGAAAACATTACAATTAGAGACTTCATTTATGGGGAA TAAGCACATTGAAGACACTGGTAGTACACCAAGCATTGGAGAAAATGACTTAAAATTCACCAAGAATTTTGGTACAGAGAATCACAGAGA AAATACAAGCCGAGAGAGGTTAGTAGTAGAAAGTTCAACGAGCTCACATATGAAGATACGTAGCCAAAGTTTCAATACAGACACTACAAC AAGTGGCATAAGTTCAATGAGCTCAAGTCCTTCACGAGAGACAGTAGGTGTAGATGCTACAACTATGGACACAGACTGTGGAAGCATGAG TACTGTGGTAAGTACTAAAACTATTAAGACAAGCCACTATTTGACGCCACAGTCTAACCATCTGTCTCTCTCCAAATCAAATTCGGTGTC CCTGGTGCCTCCAGGTTCTTCTCATACGCTTCCTAGAAGAGCACAGTCCCTTAAAGCACCCTCTATTGCTACAATTAAAAGTCTAGCAGA TTGTAACTTTAGTTACACAAGTTCTAGAGATGCTTTTGGCTATGCTACACTGAAAAGACTACAGCAACAAAGAATGCATCCATCCTTATC TCACTCTGAAGCTTTGGCATCTCCAGCAAAAGATGTGCTATTTACTGATACCATCACCATGAAGGCCAACAGTTTTGAGTCCAGATTAAC ACCAAGCAGGATCGATTTTAAAAAGAAGCATGTCGGGGGAATCAGGAGCTTAAGACCTACAATAACAAACAACCTTTTCAGGTTCATGAA AGCCTTAAGTTATGCATCATTAGATAAAGAAGATTTATTGAGTCCTATTAATCAAAATACCCTGCAACGATCTTCCTCAGTGCGGTCCAT GGTGTCCAGTGCCACATATGGGGGTTCAGATGATTACATTGGTCTTGCTCTCCCGGTGGATATAAATGATATATTCCAGGTAAAGGATAT TCCCTATTTTCAGACAAAAAACATACCACCACATGATGATCGAGGTGCAAGAGCATTTGCCCATGATGCAGGAGGTCTTCCATCTGGAAC TGGAGGTCTTGTAAAAAATTCTTTTCACTTGCTACGACAGCAGATGAGTCTTACGGAAATAATGAATTCAATCCATTCAGATGCCTCTCT GTTTTTAGAAAGTACAGAAGACACTGGACTACAGGAACATACAGATGATAACTGCCTTTATTGTGTCTGTATTGAAATTCTGGGTTTCCA GCCCAGCAACCAACTGAGTGCAATATGTAGTCATTCAGACTTTCAAGATATTCCATATTCTGATTGGTGTGAGCAGACTATCCATAATCC TTTAGAAGTGGTTCCCTCTAAGTTTTCGGGGATTTCTGGATGCAGTGATGGGGTGTCTCAAGAAGGCTCAGCTAGCAGCACCAAAAGCAC AGAATTGTTACTAGGTGTTAAAACAATTCCAGATGATACACCAATGTGCCGTATACTCCTTCGCAAAGAAGTTCTAAGATTAGTCATTAA TTTGAGTAGTTCAGTTTCAACTAAATGTCATGAGACTGGGCTTTTAACAATTAAGGAGAAGTATCCTCAAACATTTGATGACATATGCCT TTACTCTGAGGTTTCCCATTTGCTGTCACACTGCACATTCAGACTTCCGTGTCGGAGGTTCATACAAGAATTATTTCAAGATGTACAGTT TCTACAAATGCATGAAGAAGCAGAGGCTGTGTTGGCAACACCACCAAAGCAACCTATAGTTGATACATCTGCTGAATCCTGACCTCATAT TTATGATGGATATAGATACATACTATATATATTCATATTTGTGGATTTCCTAAAAGCCTCAGAAAATACGACTGACTAGGCAGCAAAGAC AGGAGTATCTTCTGTACACTGTTCCGCAGTTACTGGTACATGAACAGTTGGAACTGCTGACTTTCCTAACCAAAACAACTTCCTTCTCTC CTTTGTTGAGCCTTTTGAGGGGTTCATGATTCATTACCACAGTTTTAAGAGTTTCAGTTACCATTGTATGCAAGAGCCAAGCACTGAATA CCTACATAGGTTTTCTATTTTCTTTCATTTTAAAAGCATAATGACAGTGGAACAATAATGGGATATGCAGAAGCACCCTTCACAAGTTAT TTCTGAATGATTTTTAGGGTAAATAATACAGATGCCTTGTTTGTTAACTAACTTGTGGAAAGCAGGAATCAGTGTCTCTAAGGCTGCATC CTATTACCACAATGGGGTGTGCTATAACTGCTGGTATTAGAGAGGGAACTTTGGCCCTTTCACGTTTTTCTTAATGTTTGTAACACTACT TCAGAGGTTTATAACCTCAAAGCAGAAGAAGAGCCTCAACAACCCGGGACTTATAAGTTATTTTTATGTTACTAGACTTGCATAAAGATT CTTGTTTTCCAACTCTTCATTTTGTTGCAATGTGTTATTACAGGATATATGAACCAATTAAGGTTTTTCACTACAGTTCTTGAATAAAAT TTAAAAATCATTTTTTATTTTAATTAAAAATATTTCCCATTTATAGAATGCATATATTTGCAATGGACTTCCACTTTCATCAACTTTCCA TCTCATCGCTTTAAACAGGAACTTGAACAAGCACTGTTAGTTTAGACCTAAAGGATAGGAAAGCATTAAATAATACTTTGGATCTCCTGA GGAAAAGATAAGTTTGCTTGCAATTTACACATTCCATGGGGAAAGAAGAGCCATATTTCCTTAAAAAAAACATTAATAAAGCTTGTTATT GAGAAAAATTGTAGTGAAAAGCCTTAAGTACCAAATTTTAAAGCAGCAGTAACTTAATTTTTATATCAGTGTTTTTGTTTTGCACAAACT AAATGCAGTGGTAGGTGGGTTTATGAGTATATTAATTGCCTTTATCCATTTGTGAAGTTAAGTTGATGAGGGCAAGGTTTTTGTTTGTTT AATTTGTATATGTCTAAAGGTATTTGGAACTTTTTACAGGAATTAAACATATATGCAAATTTGTATATAAAAATAGCATGGCCATCATTT GAATGCTTGTAAATGAAAGGATTATCTTTTTTGAGATCTATATATAAATAGAAATAGAAAATCCAGCTGGACTGATTAGGATTCTTTTTT AATTCATTTGTGTATAACATTTTTATTACAATTACACATCAGTTTTGACACAGTCATAGCAACATTAATATTTTCCCATGATGCAGATCC TTTTTGTAATGGGCTTGTTCTTTGAGATCTCTGTAAAGAACCCTGTGAACTAGAAAACATAACTCACAGAGATACTTTTTTAAAAAATTT ATTTACTGGAACTGAAAGTTCCAGTTGGGATGAAGCATTTCATCTCACTTCATAACACCTCTTTGACTGCACTTCAGTGAATTGTTCTTA TGTGCACTGTGTAGCAACTTACATTATAACAAAGCAGATAAGGGCTGTAAGCTGCTGCTTATGTTGAAAAGTGGTTCTTCAGATTTTCTC TCATAAAATCCAGTTGAAGATAAATAATTTTTTTATACTTTATCACTGAACCCAAGTGTTTATTTAAATGTCAACAGTACTTCTAAGAAC GTTGCCTGTCATCGTGGTCTTTGGTCTTGGATAACTAAACTGCCTTTCCAGAGAACCAAATGTCAGAGTTACTAGACCAAATAGTGGTTA AAACCTCCAAAGGAAGTAATGTAATCTTATTCATAATGGGATTAACATATTTTAGACATTCATTTTAAACACTACCTCAGTTAATATAGA GTATAAAAATCTGTGGTTTAATCCCTCAAAAGTTAACAGTAATTTTTTTTTTGTCTTACACACACACACACCCCCTCCCCCACCATCACT ATCCCTGTACCCTCACCTTGGTCATCTATCCTGAAATAAGGCTTAGTTAGTATTGGCCTGAATGTTTTGTGTTTTTTTTTTTGTTTTTTT TTTTTACTGTTACTTTGAAAAATATGTATGTATACCTTATCATATCTGCCTATATCACTTACTTTGGGGAGATACTCAGAGCTTTGTGGT TATCAGTATACTAAAAAAAAAAAAAA >98629_98629_3_VWA8-RICTOR_VWA8_chr13_42534989_ENST00000379310_RICTOR_chr5_38964994_ENST00000296782_length(amino acids)=1374AA_BP=75 MHGTPLDPRAPSPSPTAPPAPCNPGFYSSGHPEATAARPRGACGCSCGRWCSAGRVATGSGRRSDCCTPARGPTQANTILPHSHSHHLHC LPTLMNMAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQKAIATHQKRDQYLRVQKDIFILKDTEEALLINLRDSQVL QHKENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYANLDLDFAKAKQLTVVGCQFTEFLLESEEDGQGYLEDLVK DIVQWLNASSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILS KILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRF LSIPKGFSYLNERGYVAKQLEKWHREYNSKYVDLIEEQLNEALTTYRKPVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEV QNIITELCRNVRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCH NWDAVRHSRKHLWPVVPDDVEQLCNELSSIPSTLSLNSESTSSRHNSESESVPSSMFILEDDRFGSSSTSTFFLDINEDTEPTFYDRSGP IKDKNSFPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTPISTVQKTLQLETSFMGNKH IEDTGSTPSIGENDLKFTKNFGTENHRENTSRERLVVESSTSSHMKIRSQSFNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMSTV VSTKTIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHS EALASPAKDVLFTDTITMKANSFESRLTPSRIDFKKKHVGGIRSLRPTITNNLFRFMKALSYASLDKEDLLSPINQNTLQRSSSVRSMVS SATYGGSDDYIGLALPVDINDIFQVKDIPYFQTKNIPPHDDRGARAFAHDAGGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDASLFL ESTEDTGLQEHTDDNCLYCVCIEILGFQPSNQLSAICSHSDFQDIPYSDWCEQTIHNPLEVVPSKFSGISGCSDGVSQEGSASSTKSTEL LLGVKTIPDDTPMCRILLRKEVLRLVINLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDVQFLQ MHEEAEAVLATPPKQPIVDTSAES -------------------------------------------------------------- >98629_98629_4_VWA8-RICTOR_VWA8_chr13_42534989_ENST00000379310_RICTOR_chr5_38964994_ENST00000357387_length(transcript)=8445nt_BP=232nt ACGGTGCCTGCACGGGACGCCGCTCGATCCCCGAGCCCCCTCGCCGTCCCCGACAGCCCCCCCGGCGCCATGCAATCCCGGCTTCTACTC CTCGGGGCACCCGGAGGCCACGGCGGCCCGGCCTCGCGGCGCATGCGGCTGCTCCTGCGGCAGGTGGTGCAGCGCAGGCCGGGTGGCGAC AGGCAGCGGCCGGAGGTCAGACTGTTGCACGCCGGCTCGGGGGCCGACACAGGCAAACACAATTCTTCCTCATTCACATAGCCATCATTT ACACTGCTTGCCAACCCTAATGAATATGGCTGCATCCTTTGATATCCCCAAGGAAAAGAGACTGCGAGCCAGTGCAGCCTTGAACTGTTT AAAACGCTTCCATGAAATGAAGAAACGAGGACCTAAGCCTTATAGTCTTCATTTAGACCACATTATTCAGAAAGCAATTGCAACACACCA GAAACGGGATCAGTATCTCCGAGTTCAGAAAGATATATTTATCCTTAAGGATACAGAGGAAGCTCTTTTAATTAACCTTAGAGATAGCCA AGTCCTTCAACATAAAGAGAATCTTGAATGGAATTGGAATCTTATAGGGACCATTCTTAAGTGGCCAAATGTAAATCTAAGAAACTATAA AGATGAACAGTTACACAGGTTTGTACGAAGACTACTTTATTTTTACAAGCCCAGCAGTAAATTATATGCCAACCTGGATCTGGATTTTGC CAAGGCCAAACAGCTCACGGTTGTAGGTTGCCAGTTTACAGAATTTCTTCTTGAATCTGAAGAGGATGGGCAAGGCTACTTAGAAGATCT AGTAAAGGATATTGTTCAGTGGCTCAATGCTTCATCTGGAATGAAACCCGAAAGAAGTCTTCAAAATAATGGTTTATTGACCACCCTTAG TCAACACTACTTTTTATTTATTGGAACACTTTCTTGCCACCCTCATGGAGTTAAAATGCTGGAAAAATGCAGTGTATTTCAGTGTCTCCT TAATCTTTGCTCCTTGAAAAACCAAGATCACTTGCTAAAACTTACTGTTTCTAGCTTGGACTATAGCAGAGATGGATTGGCTAGAGTCAT CCTTTCCAAAATTTTAACTGCAGCTACTGATGCCTGCAGACTCTATGCAACAAAACATTTAAGGGTATTATTGAGAGCTAATGTTGAATT CTTTAATAATTGGGGAATTGAGTTGTTAGTGACCCAGCTACATGATAAAAACAAAACGATTTCCTCTGAAGCTCTTGATATCCTCGATGA AGCATGTGAAGACAAGGCCAATCTTCATGCTCTCATTCAGATGAAACCAGCGTTATCCCACCTTGGAGACAAGGGTTTGCTTCTCCTGCT GAGATTTCTCTCCATTCCAAAAGGATTTTCCTATCTGAATGAAAGAGGTTATGTAGCAAAACAATTGGAAAAGTGGCACAGGGAATACAA CTCCAAATATGTTGACTTGATTGAGGAACAACTCAATGAAGCACTTACTACTTACCGGAAGCCTGTTGATGGTGATAACTATGTTCGTCG GAGTAACCAAAGATTACAGCGTCCTCACGTCTACCTGCCTATACACCTTTATGGACAACTAGTACACCATAAAACAGGCTGCCATTTGTT GGAAGTACAGAATATTATTACAGAACTCTGTCGTAATGTTCGTACACCAGATTTGGATAAGTGGGAAGAAATTAAAAAACTGAAAGCATC TCTTTGGGCCTTGGGAAATATCGGCTCATCAAATTGGGGTCTCAATTTGCTACAGGAAGAAAACGTGATTCCAGATATACTAAAACTTGC AAAACAGTGTGAAGTTCTTTCCATCAGAGGGACCTGTGTATATGTACTTGGGCTCATAGCTAAAACCAAACAAGGCTGTGATATTCTAAA ATGTCACAACTGGGATGCTGTGAGGCATAGTCGCAAACATCTGTGGCCAGTGGTTCCAGATGATGTGGAACAACTCTGTAATGAACTTTC ATCTATCCCAAGCACTCTAAGTTTGAACTCGGAGTCAACCAGCTCTAGACATAATAGTGAAAGTGAATCTGTGCCATCGAGTATGTTCAT ATTGGAGGATGACCGGTTTGGCAGCAGCTCTACTAGCACATTTTTCCTTGATATCAATGAAGATACAGAGCCAACATTTTATGACCGATC TGGACCCATAAAGGATAAAAATTCATTCCCTTTCTTTGCTTCTAGTAAACTTGTGAAGAATCGTATCTTAAATTCGCTTACTTTGCCTAA CAAAAAACATCGTAGTAGCAGTGATCCAAAAGGAGGGAAATTATCATCTGAAAGTAAGACAAGCAACAGGCGAATCAGAACACTTACGGA GCCCAGTGTTGATTTTAATCATAGTGATGATTTTACACCCATATCCACTGTACAGAAAACATTACAATTAGAGACTTCATTTATGGGGAA TAAGCACATTGAAGACACTGGTAGTACACCAAGCATTGGAGAAAATGACTTAAAATTCACCAAGAATTTTGGTACAGAGAATCACAGAGA AAATACAAGCCGAGAGAGGTTAGTAGTAGAAAGTTCAACGAGCTCACATATGAAGATACGTAGCCAAAGTTTCAATACAGACACTACAAC AAGTGGCATAAGTTCAATGAGCTCAAGTCCTTCACGAGAGACAGTAGGTGTAGATGCTACAACTATGGACACAGACTGTGGAAGCATGAG TACTGTGGTAAGTACTAAAACTATTAAGACAAGCCACTATTTGACGCCACAGTCTAACCATCTGTCTCTCTCCAAATCAAATTCGGTGTC CCTGGTGCCTCCAGGTTCTTCTCATACGCTTCCTAGAAGAGCACAGTCCCTTAAAGCACCCTCTATTGCTACAATTAAAAGTCTAGCAGA TTGTAACTTTAGTTACACAAGTTCTAGAGATGCTTTTGGCTATGCTACACTGAAAAGACTACAGCAACAAAGAATGCATCCATCCTTATC TCACTCTGAAGCTTTGGCATCTCCAGCAAAAGATGTGCTATTTACTGATACCATCACCATGAAGGCCAACAGTTTTGAGTCCAGATTAAC ACCAAGCAGGTTCATGAAAGCCTTAAGTTATGCATCATTAGATAAAGAAGATTTATTGAGTCCTATTAATCAAAATACCCTGCAACGATC TTCCTCAGTGCGGTCCATGGTGTCCAGTGCCACATATGGGGGTTCAGATGATTACATTGGTCTTGCTCTCCCGGTGGATATAAATGATAT ATTCCAGGTAAAGGATATTCCCTATTTTCAGACAAAAAACATACCACCACATGATGATCGAGGTGCAAGAGCATTTGCCCATGATGCAGG AGGTCTTCCATCTGGAACTGGAGGTCTTGTAAAAAATTCTTTTCACTTGCTACGACAGCAGATGAGTCTTACGGAAATAATGAATTCAAT CCATTCAGATGCCTCTCTGTTTTTAGAAAGTACAGAAGACACTGGACTACAGGAACATACAGATGATAACTGCCTTTATTGTGTCTGTAT TGAAATTCTGGGTTTCCAGCCCAGCAACCAACTGAGTGCAATATGTAGTCATTCAGACTTTCAAGATATTCCATATTCTGATTGGTGTGA GCAGACTATCCATAATCCTTTAGAAGTGGTTCCCTCTAAGTTTTCGGGGATTTCTGGATGCAGTGATGGGGTGTCTCAAGAAGGCTCAGC TAGCAGCACCAAAAGCACAGAATTGTTACTAGGTGTTAAAACAATTCCAGATGATACACCAATGTGCCGTATACTCCTTCGCAAAGAAGT TCTAAGATTAGTCATTAATTTGAGTAGTTCAGTTTCAACTAAATGTCATGAGACTGGGCTTTTAACAATTAAGGAGAAGTATCCTCAAAC ATTTGATGACATATGCCTTTACTCTGAGGTTTCCCATTTGCTGTCACACTGCACATTCAGACTTCCGTGTCGGAGGTTCATACAAGAATT ATTTCAAGATGTACAGTTTCTACAAATGCATGAAGAAGCAGAGGCTGTGTTGGCAACACCACCAAAGCAACCTATAGTTGATACATCTGC TGAATCCTGACCTCATATTTATGATGGATATAGATACATACTATATATATTCATATTTGTGGATTTCCTAAAAGCCTCAGAAAATACGAC TGACTAGGCAGCAAAGACAGGAGTATCTTCTGTACACTGTTCCGCAGTTACTGGTACATGAACAGTTGGAACTGCTGACTTTCCTAACCA AAACAACTTCCTTCTCTCCTTTGTTGAGCCTTTTGAGGGGTTCATGATTCATTACCACAGTTTTAAGAGTTTCAGTTACCATTGTATGCA AGAGCCAAGCACTGAATACCTACATAGGTTTTCTATTTTCTTTCATTTTAAAAGCATAATGACAGTGGAACAATAATGGGATATGCAGAA GCACCCTTCACAAGTTATTTCTGAATGATTTTTAGGGTAAATAATACAGATGCCTTGTTTGTTAACTAACTTGTGGAAAGCAGGAATCAG TGTCTCTAAGGCTGCATCCTATTACCACAATGGGGTGTGCTATAACTGCTGGTATTAGAGAGGGAACTTTGGCCCTTTCACGTTTTTCTT AATGTTTGTAACACTACTTCAGAGGTTTATAACCTCAAAGCAGAAGAAGAGCCTCAACAACCCGGGACTTATAAGTTATTTTTATGTTAC TAGACTTGCATAAAGATTCTTGTTTTCCAACTCTTCATTTTGTTGCAATGTGTTATTACAGGATATATGAACCAATTAAGGTTTTTCACT ACAGTTCTTGAATAAAATTTAAAAATCATTTTTTATTTTAATTAAAAATATTTCCCATTTATAGAATGCATATATTTGCAATGGACTTCC ACTTTCATCAACTTTCCATCTCATCGCTTTAAACAGGAACTTGAACAAGCACTGTTAGTTTAGACCTAAAGGATAGGAAAGCATTAAATA ATACTTTGGATCTCCTGAGGAAAAGATAAGTTTGCTTGCAATTTACACATTCCATGGGGAAAGAAGAGCCATATTTCCTTAAAAAAAACA TTAATAAAGCTTGTTATTGAGAAAAATTGTAGTGAAAAGCCTTAAGTACCAAATTTTAAAGCAGCAGTAACTTAATTTTTATATCAGTGT TTTTGTTTTGCACAAACTAAATGCAGTGGTAGGTGGGTTTATGAGTATATTAATTGCCTTTATCCATTTGTGAAGTTAAGTTGATGAGGG CAAGGTTTTTGTTTGTTTAATTTGTATATGTCTAAAGGTATTTGGAACTTTTTACAGGAATTAAACATATATGCAAATTTGTATATAAAA ATAGCATGGCCATCATTTGAATGCTTGTAAATGAAAGGATTATCTTTTTTGAGATCTATATATAAATAGAAATAGAAAATCCAGCTGGAC TGATTAGGATTCTTTTTTAATTCATTTGTGTATAACATTTTTATTACAATTACACATCAGTTTTGACACAGTCATAGCAACATTAATATT TTCCCATGATGCAGATCCTTTTTGTAATGGGCTTGTTCTTTGAGATCTCTGTAAAGAACCCTGTGAACTAGAAAACATAACTCACAGAGA TACTTTTTTAAAAAATTTATTTACTGGAACTGAAAGTTCCAGTTGGGATGAAGCATTTCATCTCACTTCATAACACCTCTTTGACTGCAC TTCAGTGAATTGTTCTTATGTGCACTGTGTAGCAACTTACATTATAACAAAGCAGATAAGGGCTGTAAGCTGCTGCTTATGTTGAAAAGT GGTTCTTCAGATTTTCTCTCATAAAATCCAGTTGAAGATAAATAATTTTTTTATACTTTATCACTGAACCCAAGTGTTTATTTAAATGTC AACAGTACTTCTAAGAACGTTGCCTGTCATCGTGGTCTTTGGTCTTGGATAACTAAACTGCCTTTCCAGAGAACCAAATGTCAGAGTTAC TAGACCAAATAGTGGTTAAAACCTCCAAAGGAAGTAATGTAATCTTATTCATAATGGGATTAACATATTTTAGACATTCATTTTAAACAC TACCTCAGTTAATATAGAGTATAAAAATCTGTGGTTTAATCCCTCAAAAGTTAACAGTAATTTTTTTTTTGTCTTACACACACACACACC CCCTCCCCCACCATCACTATCCCTGTACCCTCACCTTGGTCATCTATCCTGAAATAAGGCTTAGTTAGTATTGGCCTGAATGTTTTGTGT TTTTTTTTTTGTTTTTTTTTTTTACTGTTACTTTGAAAAATATGTATGTATACCTTATCATATCTGCCTATATCACTTACTTTGGGGAGA TACTCAGAGCTTTGTGGTTATCAGTATACTAAAAAAAAAAAAAAGTCTACGCTTAAATTTATAGTGCTATTTGGTTTCTCCATGATTTCA CTGACAGGTCTAATACATTTTCTTTGAGTACTTGTTTGTAAAAAGTAGACTTTATGGTGAAAAATACATGCAGTGCCAAGTGATTAACTT AAGTGTTTAAAAATATTAAATTATAGCAGAAGAGGTTAGGAATGATATCAGCAGTAATAGAAATAATTGAGAAAATCATCTATAAATAAT AGATATTACAGACTATAGAATACCAAAATAATGTCAATACTGTAGTTTTTAAAGATTTTAGGATTAATCTTAGTCCATATAAATTTGTAC TATTGGTAATTATTGAATAATTGGGAGGAATCTGGGCAGTTGTGCTGGTTGTAAACTATGAATTTCTAATCGTAAAGTGAATTGTTATTT CTAATTGAACTTTTTTTCAAGAACAGATTTCAGCCTCACATACTAAGTAAATACTGATAAATAAGGAAATTAGAAATTTAGTATTCATAA TTAAATATGCTCTAAAATTTCCTATACTTTTATTTCCTGTTTATTCTTAGGTAGATTGGAAGGGGGAAACAGTCTGTTCTCCCTAATTAA ATTTTTTCTAATAACGATTAGTAGAATATGGACATTCTATATGACAGTGACATTAAAAGAGGCTCTTTGGAAGTATATACATTATTAACA TAATGTGTACAAGTCCTTTTGAAATGACAACTTTAATGGGTTTCAGCTCTTTTATCTAGAGCTTGAGATAATTCAAGCTGAGTTTTTCAG GGCATATCACAACGGCCAAGTGTTCAGCAGTGGGATATCAATGCTTATTTACATTTTCCTACTGCTATTTATATAAAATGTTATTCCATT CAGAGGATGCCTTTTATCCCCACATTAAAGCACAGATCATTAAGCAATAAAAACCAAATTGTCTGTCATTCAAATTATAACTGCAGTTAT TTTTGCATGGTAAGAGTGAGGTGCTAATTTTGTGTGAGATGAACTTTGTAAACTACTTTGGGAAATGTTCTTTGGAAGTAAGGTTTTTTC TCCTTTAGTCTTATGCTTCCACTTTTGTCTCAGATTCACAATCCATTAAAACATGGGGAAAAAAGAAAAGGTAAAATTGAGAGACTTTTG TTAGAGGAGCTATTTGGAATGAACCAACATTTCAGATTTTCCAAAATGTAAGTTAGGAAGTCTCCATTGTCTCTGCATTAACAAAATACA CTGTTACTATCTTAATCTCAAGAGTGTCATTACAGTGAGAATCTCATTTAAAAGCATACCAGTGAAATTAATAGCAGTGCTTATCAAAGA ACACTGAAATCTGTGAGAATCTTTCTAGGAGCATTCTTTTCTTCTTTTAGTTCCAAGTTCCAGGGTATTTTTCATTCCTAGTAGGTTTAT ATGACTCACAGAATGTGGACTTTTTTCCTGTTTGGAGTATTTTTGTAATGTAAGTATCGGATAGCTGCACCACAGCATGCATAAATTGCA CATTTTGTTTTACTTTCTTTATAGAATATTTAATTTCAAAAATATAATTTATGCCAAAAAAAGCATACCTTTCAATTTTGCTACTTGGTT GATTTAGCACAAAATGCAAAGTCTTGGGGCAGAGAGGGGGAGTGAAAAAAATTTTATAGGTAATTGTTACAAAAATACCTGTCAGAAACC CTAAAGCTGCATTGTAAAACAAATGGTGTAAACTAGTTTTGAAAAGTGGTAAGGAATTGTGAAAAAAATCTCAGACTTAATGCTCTCTAA CCACATGAGTTTCTTCTTTTTTATTTAGTAATACGCTGCTACATATTTGGAGGTTCTGGTGTTTGTAGGTCACTGAACAGACATTGAAAT CTGATTTATATTGTATAACTGTAACATAGAAAGAAAAAGTATTTATATTTTTTCTGTAAGAATATTTCATTGAGTTGTGTATAATTTAAA TAAGATTTGTCCCCAAATGGTTTTGCTCACCTTGATTTTTTTTGTTGTGATTTTCTTGTTTTTGTATAATGTGTATAGTTTATGTCAAGG GCATTAAAAGCCTCCTGAAGCATAATCTTATCAAAGGGATACATTGTTAATAAAATGTACTTAAAATTCTTAAAC >98629_98629_4_VWA8-RICTOR_VWA8_chr13_42534989_ENST00000379310_RICTOR_chr5_38964994_ENST00000357387_length(amino acids)=1350AA_BP=75 MHGTPLDPRAPSPSPTAPPAPCNPGFYSSGHPEATAARPRGACGCSCGRWCSAGRVATGSGRRSDCCTPARGPTQANTILPHSHSHHLHC LPTLMNMAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQKAIATHQKRDQYLRVQKDIFILKDTEEALLINLRDSQVL QHKENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYANLDLDFAKAKQLTVVGCQFTEFLLESEEDGQGYLEDLVK DIVQWLNASSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILS KILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRF LSIPKGFSYLNERGYVAKQLEKWHREYNSKYVDLIEEQLNEALTTYRKPVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEV QNIITELCRNVRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCH NWDAVRHSRKHLWPVVPDDVEQLCNELSSIPSTLSLNSESTSSRHNSESESVPSSMFILEDDRFGSSSTSTFFLDINEDTEPTFYDRSGP IKDKNSFPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTPISTVQKTLQLETSFMGNKH IEDTGSTPSIGENDLKFTKNFGTENHRENTSRERLVVESSTSSHMKIRSQSFNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMSTV VSTKTIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHS EALASPAKDVLFTDTITMKANSFESRLTPSRFMKALSYASLDKEDLLSPINQNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQ VKDIPYFQTKNIPPHDDRGARAFAHDAGGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDASLFLESTEDTGLQEHTDDNCLYCVCIEI LGFQPSNQLSAICSHSDFQDIPYSDWCEQTIHNPLEVVPSKFSGISGCSDGVSQEGSASSTKSTELLLGVKTIPDDTPMCRILLRKEVLR LVINLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDVQFLQMHEEAEAVLATPPKQPIVDTSAES -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for VWA8-RICTOR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | VWA8 | chr13:42534989 | chr5:38964994 | ENST00000281496 | - | 1 | 26 | 1_261 | 54.333333333333336 | 1040.0 | PEX7 |
| Hgene | VWA8 | chr13:42534989 | chr5:38964994 | ENST00000379310 | - | 1 | 45 | 1_261 | 54.333333333333336 | 1906.0 | PEX7 |
| Tgene | RICTOR | chr13:42534989 | chr5:38964994 | ENST00000296782 | 14 | 39 | 1_789 | 433.0 | 1733.0 | NBN | |
| Tgene | RICTOR | chr13:42534989 | chr5:38964994 | ENST00000357387 | 14 | 38 | 1_789 | 433.0 | 1709.0 | NBN |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for VWA8-RICTOR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for VWA8-RICTOR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | VWA8 | C0004352 | Autistic Disorder | 1 | CTD_human |
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