Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARHGAP26-CAST (FusionGDB2 ID:HG23092TG831)

Fusion Gene Summary for ARHGAP26-CAST

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP26-CAST
Fusion gene ID: hg23092tg831
HgeneTgene
Gene symbol

ARHGAP26

CAST

Gene ID

23092

831

Gene nameRho GTPase activating protein 26calpastatin
SynonymsGRAF|GRAF1|OPHN1L|OPHN1L1BS-17|PLACK
Cytomap('ARHGAP26')('CAST')

5q31.3

5q15

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 26GTPase regulator associated with focal adhesion kinase pp125(FAK)oligophrenin-1-like proteincalpastatincalpain inhibitorsperm BS-17 component
Modification date2020031320200313
UniProtAcc

Q9UNA1

P20810

Ensembl transtripts involved in fusion geneENST00000274498, ENST00000378004, 
ENST00000486650, 
Fusion gene scores* DoF score24 X 18 X 6=259210 X 9 X 8=720
# samples 2213
** MAII scorelog2(22/2592*10)=-3.55849028935997
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP26 [Title/Abstract] AND CAST [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP26(142311690)-CAST(96011243), # samples:1
ARHGAP26(142311690)-CAST(96011242), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAST

GO:2000675

negative regulation of type B pancreatic cell apoptotic process

15044459



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8528-01AARHGAP26chr5

142311690

+CASTchr5

96011243

+
ChimerDB4STADTCGA-CD-8528ARHGAP26chr5

142311690

+CASTchr5

96011242

+


Top

Fusion Gene ORF analysis for ARHGAP26-CAST

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000274498ENST00000325674ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000274498ENST00000325674ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000274498ENST00000338252ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000274498ENST00000338252ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000274498ENST00000359176ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000274498ENST00000359176ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000274498ENST00000395812ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000274498ENST00000395812ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000274498ENST00000395813ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000274498ENST00000395813ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000274498ENST00000508608ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000274498ENST00000508608ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000274498ENST00000508830ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000274498ENST00000508830ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000274498ENST00000510756ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000274498ENST00000510756ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000378004ENST00000325674ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000378004ENST00000325674ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000378004ENST00000338252ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000378004ENST00000338252ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000378004ENST00000359176ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000378004ENST00000359176ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000378004ENST00000395812ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000378004ENST00000395812ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000378004ENST00000395813ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000378004ENST00000395813ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000378004ENST00000508608ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000378004ENST00000508608ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000378004ENST00000508830ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000378004ENST00000508830ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-5UTRENST00000378004ENST00000510756ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-5UTRENST00000378004ENST00000510756ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000274498ENST00000309190ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000274498ENST00000309190ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000274498ENST00000341926ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000274498ENST00000341926ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000274498ENST00000348386ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000274498ENST00000348386ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000274498ENST00000504465ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000274498ENST00000504465ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000274498ENST00000508579ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000274498ENST00000508579ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000274498ENST00000509903ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000274498ENST00000509903ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000274498ENST00000511049ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000274498ENST00000511049ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000274498ENST00000511782ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000274498ENST00000511782ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000274498ENST00000515663ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000274498ENST00000515663ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000378004ENST00000309190ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000378004ENST00000309190ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000378004ENST00000341926ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000378004ENST00000341926ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000378004ENST00000348386ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000378004ENST00000348386ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000378004ENST00000504465ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000378004ENST00000504465ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000378004ENST00000508579ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000378004ENST00000508579ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000378004ENST00000509903ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000378004ENST00000509903ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000378004ENST00000511049ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000378004ENST00000511049ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000378004ENST00000511782ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000378004ENST00000511782ARHGAP26chr5

142311690

+CASTchr5

96011242

+
5CDS-intronENST00000378004ENST00000515663ARHGAP26chr5

142311690

+CASTchr5

96011243

+
5CDS-intronENST00000378004ENST00000515663ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-5UTRENST00000486650ENST00000325674ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-5UTRENST00000486650ENST00000325674ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-5UTRENST00000486650ENST00000338252ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-5UTRENST00000486650ENST00000338252ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-5UTRENST00000486650ENST00000359176ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-5UTRENST00000486650ENST00000359176ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-5UTRENST00000486650ENST00000395812ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-5UTRENST00000486650ENST00000395812ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-5UTRENST00000486650ENST00000395813ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-5UTRENST00000486650ENST00000395813ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-5UTRENST00000486650ENST00000508608ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-5UTRENST00000486650ENST00000508608ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-5UTRENST00000486650ENST00000508830ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-5UTRENST00000486650ENST00000508830ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-5UTRENST00000486650ENST00000510756ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-5UTRENST00000486650ENST00000510756ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-intronENST00000486650ENST00000309190ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-intronENST00000486650ENST00000309190ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-intronENST00000486650ENST00000341926ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-intronENST00000486650ENST00000341926ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-intronENST00000486650ENST00000348386ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-intronENST00000486650ENST00000348386ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-intronENST00000486650ENST00000504465ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-intronENST00000486650ENST00000504465ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-intronENST00000486650ENST00000508579ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-intronENST00000486650ENST00000508579ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-intronENST00000486650ENST00000509903ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-intronENST00000486650ENST00000509903ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-intronENST00000486650ENST00000511049ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-intronENST00000486650ENST00000511049ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-intronENST00000486650ENST00000511782ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-intronENST00000486650ENST00000511782ARHGAP26chr5

142311690

+CASTchr5

96011242

+
intron-intronENST00000486650ENST00000515663ARHGAP26chr5

142311690

+CASTchr5

96011243

+
intron-intronENST00000486650ENST00000515663ARHGAP26chr5

142311690

+CASTchr5

96011242

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ARHGAP26-CAST


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGAP26chr5142311690+CASTchr596011242+1.42E-060.99999857
ARHGAP26chr5142311690+CASTchr596011242+1.42E-060.99999857
ARHGAP26chr5142311690+CASTchr596011242+1.42E-060.99999857
ARHGAP26chr5142311690+CASTchr596011242+1.42E-060.99999857


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ARHGAP26-CAST


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:142311690/:96011243)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP26

Q9UNA1

CAST

P20810

FUNCTION: GTPase-activating protein for RHOA and CDC42.FUNCTION: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ARHGAP26-CAST


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ARHGAP26-CAST


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARHGAP26-CAST


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARHGAP26-CAST


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP26C0033975Psychotic Disorders1PSYGENET
TgeneC0027540Necrosis1CTD_human
TgeneC0162557Liver Failure, Acute1CTD_human
TgeneC4225381PEELING SKIN WITH LEUKONYCHIA, ACRAL PUNCTATE KERATOSES, CHEILITIS, AND KNUCKLE PADS1CTD_human;GENOMICS_ENGLAND;ORPHANET