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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ARHGAP26-CAST (FusionGDB2 ID:HG23092TG831) |
Fusion Gene Summary for ARHGAP26-CAST |
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Fusion gene information | Fusion gene name: ARHGAP26-CAST | Fusion gene ID: hg23092tg831 | Hgene | Tgene | Gene symbol | ARHGAP26 | CAST | Gene ID | 23092 | 831 |
Gene name | Rho GTPase activating protein 26 | calpastatin | |
Synonyms | GRAF|GRAF1|OPHN1L|OPHN1L1 | BS-17|PLACK | |
Cytomap | ('ARHGAP26')('CAST') 5q31.3 | 5q15 | |
Type of gene | protein-coding | protein-coding | |
Description | rho GTPase-activating protein 26GTPase regulator associated with focal adhesion kinase pp125(FAK)oligophrenin-1-like protein | calpastatincalpain inhibitorsperm BS-17 component | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9UNA1 | P20810 | |
Ensembl transtripts involved in fusion gene | ENST00000274498, ENST00000378004, ENST00000486650, | ||
Fusion gene scores | * DoF score | 24 X 18 X 6=2592 | 10 X 9 X 8=720 |
# samples | 22 | 13 | |
** MAII score | log2(22/2592*10)=-3.55849028935997 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/720*10)=-2.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ARHGAP26 [Title/Abstract] AND CAST [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ARHGAP26(142311690)-CAST(96011243), # samples:1 ARHGAP26(142311690)-CAST(96011242), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CAST | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process | 15044459 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-CD-8528-01A | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
ChimerDB4 | STAD | TCGA-CD-8528 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
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Fusion Gene ORF analysis for ARHGAP26-CAST |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000274498 | ENST00000325674 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000274498 | ENST00000325674 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000274498 | ENST00000338252 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000274498 | ENST00000338252 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000274498 | ENST00000359176 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000274498 | ENST00000359176 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000274498 | ENST00000395812 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000274498 | ENST00000395812 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000274498 | ENST00000395813 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000274498 | ENST00000395813 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000274498 | ENST00000508608 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000274498 | ENST00000508608 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000274498 | ENST00000508830 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000274498 | ENST00000508830 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000274498 | ENST00000510756 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000274498 | ENST00000510756 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000378004 | ENST00000325674 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000378004 | ENST00000325674 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000378004 | ENST00000338252 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000378004 | ENST00000338252 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000378004 | ENST00000359176 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000378004 | ENST00000359176 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000378004 | ENST00000395812 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000378004 | ENST00000395812 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000378004 | ENST00000395813 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000378004 | ENST00000395813 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000378004 | ENST00000508608 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000378004 | ENST00000508608 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000378004 | ENST00000508830 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000378004 | ENST00000508830 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-5UTR | ENST00000378004 | ENST00000510756 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-5UTR | ENST00000378004 | ENST00000510756 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000274498 | ENST00000309190 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000274498 | ENST00000309190 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000274498 | ENST00000341926 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000274498 | ENST00000341926 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000274498 | ENST00000348386 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000274498 | ENST00000348386 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000274498 | ENST00000504465 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000274498 | ENST00000504465 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000274498 | ENST00000508579 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000274498 | ENST00000508579 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000274498 | ENST00000509903 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000274498 | ENST00000509903 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000274498 | ENST00000511049 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000274498 | ENST00000511049 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000274498 | ENST00000511782 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000274498 | ENST00000511782 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000274498 | ENST00000515663 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000274498 | ENST00000515663 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000378004 | ENST00000309190 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000378004 | ENST00000309190 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000378004 | ENST00000341926 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000378004 | ENST00000341926 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000378004 | ENST00000348386 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000378004 | ENST00000348386 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000378004 | ENST00000504465 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000378004 | ENST00000504465 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000378004 | ENST00000508579 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000378004 | ENST00000508579 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000378004 | ENST00000509903 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000378004 | ENST00000509903 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000378004 | ENST00000511049 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000378004 | ENST00000511049 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000378004 | ENST00000511782 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000378004 | ENST00000511782 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
5CDS-intron | ENST00000378004 | ENST00000515663 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
5CDS-intron | ENST00000378004 | ENST00000515663 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-5UTR | ENST00000486650 | ENST00000325674 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-5UTR | ENST00000486650 | ENST00000325674 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-5UTR | ENST00000486650 | ENST00000338252 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-5UTR | ENST00000486650 | ENST00000338252 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-5UTR | ENST00000486650 | ENST00000359176 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-5UTR | ENST00000486650 | ENST00000359176 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-5UTR | ENST00000486650 | ENST00000395812 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-5UTR | ENST00000486650 | ENST00000395812 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-5UTR | ENST00000486650 | ENST00000395813 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-5UTR | ENST00000486650 | ENST00000395813 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-5UTR | ENST00000486650 | ENST00000508608 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-5UTR | ENST00000486650 | ENST00000508608 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-5UTR | ENST00000486650 | ENST00000508830 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-5UTR | ENST00000486650 | ENST00000508830 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-5UTR | ENST00000486650 | ENST00000510756 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-5UTR | ENST00000486650 | ENST00000510756 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-intron | ENST00000486650 | ENST00000309190 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-intron | ENST00000486650 | ENST00000309190 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-intron | ENST00000486650 | ENST00000341926 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-intron | ENST00000486650 | ENST00000341926 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-intron | ENST00000486650 | ENST00000348386 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-intron | ENST00000486650 | ENST00000348386 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-intron | ENST00000486650 | ENST00000504465 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-intron | ENST00000486650 | ENST00000504465 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-intron | ENST00000486650 | ENST00000508579 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-intron | ENST00000486650 | ENST00000508579 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-intron | ENST00000486650 | ENST00000509903 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-intron | ENST00000486650 | ENST00000509903 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-intron | ENST00000486650 | ENST00000511049 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-intron | ENST00000486650 | ENST00000511049 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-intron | ENST00000486650 | ENST00000511782 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-intron | ENST00000486650 | ENST00000511782 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
intron-intron | ENST00000486650 | ENST00000515663 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011243 | + |
intron-intron | ENST00000486650 | ENST00000515663 | ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ARHGAP26-CAST |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + | 1.42E-06 | 0.99999857 |
ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + | 1.42E-06 | 0.99999857 |
ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + | 1.42E-06 | 0.99999857 |
ARHGAP26 | chr5 | 142311690 | + | CAST | chr5 | 96011242 | + | 1.42E-06 | 0.99999857 |
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Fusion Protein Features for ARHGAP26-CAST |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:142311690/:96011243) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ARHGAP26 | CAST |
FUNCTION: GTPase-activating protein for RHOA and CDC42. | FUNCTION: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ARHGAP26-CAST |
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Fusion Gene PPI Analysis for ARHGAP26-CAST |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARHGAP26-CAST |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARHGAP26-CAST |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ARHGAP26 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Tgene | C0027540 | Necrosis | 1 | CTD_human | |
Tgene | C0162557 | Liver Failure, Acute | 1 | CTD_human | |
Tgene | C4225381 | PEELING SKIN WITH LEUKONYCHIA, ACRAL PUNCTATE KERATOSES, CHEILITIS, AND KNUCKLE PADS | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET |