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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDK19-ZFAND3 (FusionGDB2 ID:HG23097TG60685)

Fusion Gene Summary for CDK19-ZFAND3

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK19-ZFAND3
Fusion gene ID: hg23097tg60685
HgeneTgene
Gene symbol

CDK19

ZFAND3

Gene ID

23097

60685

Gene namecyclin dependent kinase 19zinc finger AN1-type containing 3
SynonymsCDC2L6|CDK11|bA346C16.3TEX27
Cytomap('CDK19')('ZFAND3')

6q21

6p21.2

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 19CDC2-related protein kinase 6CDK8-like cyclin-dependent kinasecell division cycle 2-like 6 (CDK8-like)cell division cycle 2-like protein kinase 6cell division protein kinase 19cyclin dependent kinase 19 variant 2cyclin-depAN1-type zinc finger protein 3testis expressed sequence 27testis-expressed protein 27zinc finger, AN1-type domain 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000368911, ENST00000323817, 
ENST00000413605, ENST00000497709, 
Fusion gene scores* DoF score12 X 10 X 7=84025 X 21 X 12=6300
# samples 1526
** MAII scorelog2(15/840*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(26/6300*10)=-4.59876830024619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDK19 [Title/Abstract] AND ZFAND3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDK19(111136212)-ZFAND3(38120011), # samples:3
Anticipated loss of major functional domain due to fusion event.CDK19-ZFAND3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDK19-ZFAND3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CDK19 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZFAND3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A24Z-01ACDK19chr6

111136212

-ZFAND3chr6

38120011

+


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Fusion Gene ORF analysis for CDK19-ZFAND3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000368911ENST00000463847CDK19chr6

111136212

-ZFAND3chr6

38120011

+
In-frameENST00000368911ENST00000287218CDK19chr6

111136212

-ZFAND3chr6

38120011

+
In-frameENST00000368911ENST00000373391CDK19chr6

111136212

-ZFAND3chr6

38120011

+
intron-3CDSENST00000323817ENST00000287218CDK19chr6

111136212

-ZFAND3chr6

38120011

+
intron-3CDSENST00000323817ENST00000373391CDK19chr6

111136212

-ZFAND3chr6

38120011

+
intron-3CDSENST00000413605ENST00000287218CDK19chr6

111136212

-ZFAND3chr6

38120011

+
intron-3CDSENST00000413605ENST00000373391CDK19chr6

111136212

-ZFAND3chr6

38120011

+
intron-3CDSENST00000497709ENST00000287218CDK19chr6

111136212

-ZFAND3chr6

38120011

+
intron-3CDSENST00000497709ENST00000373391CDK19chr6

111136212

-ZFAND3chr6

38120011

+
intron-3UTRENST00000323817ENST00000463847CDK19chr6

111136212

-ZFAND3chr6

38120011

+
intron-3UTRENST00000413605ENST00000463847CDK19chr6

111136212

-ZFAND3chr6

38120011

+
intron-3UTRENST00000497709ENST00000463847CDK19chr6

111136212

-ZFAND3chr6

38120011

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000368911CDK19chr6111136212-ENST00000287218ZFAND3chr638120011+269830823951946149
ENST00000368911CDK19chr6111136212-ENST00000373391ZFAND3chr638120011+269830823951946149

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368911ENST00000287218CDK19chr6111136212-ZFAND3chr638120011+0.636075560.36392438
ENST00000368911ENST00000373391CDK19chr6111136212-ZFAND3chr638120011+0.636075560.36392438

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Fusion Genomic Features for CDK19-ZFAND3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDK19chr6111136211-ZFAND3chr638120010+6.46E-121
CDK19chr6111136211-ZFAND3chr638120010+6.46E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CDK19-ZFAND3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:111136212/chr6:38120011)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK19chr6:111136212chr6:38120011ENST00000368911-11327_3542503.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK19chr6:111136212chr6:38120011ENST00000323817-114372_4040443.0Compositional biasNote=Gln-rich
HgeneCDK19chr6:111136212chr6:38120011ENST00000323817-114461_4910443.0Compositional biasNote=Ser-rich
HgeneCDK19chr6:111136212chr6:38120011ENST00000368911-113372_40442503.0Compositional biasNote=Gln-rich
HgeneCDK19chr6:111136212chr6:38120011ENST00000368911-113461_49142503.0Compositional biasNote=Ser-rich
HgeneCDK19chr6:111136212chr6:38120011ENST00000323817-11421_3350443.0DomainProtein kinase
HgeneCDK19chr6:111136212chr6:38120011ENST00000368911-11321_33542503.0DomainProtein kinase
HgeneCDK19chr6:111136212chr6:38120011ENST00000323817-11427_350443.0Nucleotide bindingATP
TgeneZFAND3chr6:111136212chr6:38120011ENST000002872184612_44176228.0Zinc fingerA20-type
TgeneZFAND3chr6:111136212chr6:38120011ENST0000028721846154_200176228.0Zinc fingerAN1-type


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Fusion Gene Sequence for CDK19-ZFAND3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15224_15224_1_CDK19-ZFAND3_CDK19_chr6_111136212_ENST00000368911_ZFAND3_chr6_38120011_ENST00000287218_length(transcript)=2698nt_BP=308nt
TGTGGCCGCCGAGGAGTCCCTTGCTGAAGGCGGACCGCGGAGCGGCGGGCGGCGGGCGGCGCGCGCGCGCGCGCGAGAGGCGGCTGTTGG
AGAAGTGGAGCGGCGGTCGCGGGGGGAGGAGGAGGAGGGACTGAGCGGCGGCGGCCCCCGCGTCCCGTGCCTCTATGGGGGAAGCAGACA
ATGGATTATGATTTCAAGGCGAAGCTGGCGGCGGAGCGGGAGCGGGTGGAGGATTTGTTTGAGTACGAAGGGTGCAAAGTGGGACGCGGC
ACCTACGGTCACGTCTACAAGGCGAGGCGGAAAGATGGGTTATGTGTTCTGTATGTTACATCGCCTCCCCGAGCAGCACGACTGCACATT
CGACCACATGGGCCGTGGCCGGGAGGAAGCCATCATGAAAATGGTGAAGCTGGACCGGAAAGTGGGGCGCTCCTGCCAGCGCATCGGGGA
GGGGTGCTCCTGAAGGCCAGGCATGGCCACCACGTGACGCTGTTCTTAGTTCACTAATGTTAGCCTTATTTAGGACAAAGTCAGCCAGAC
ACCTTGTACTGGGCACGCGTCAGACTGCAGCCAGTCCGTTTCCTTTCTTTAGCCAGCCATCCTGGTACTGTAGTTTAGGGGTTGATGGTG
GTTGAAATTGATTTCTGGCTGGTTACTAAGGTGCCTGCTAGCCATTGTATAAAATTAAAACATGAAGAATATTTTTTTTTTGAGCATGGC
TAGTGGATTTAAAACAACACATACCTGTCACTGCTGGAGTCAAACTTATAAAAAGCCTTAAGTGGAAAGTGTTCCAGACGGAGACTCTGA
GTTAATAGAGGAGTAGAAGCTGGTGTTAAAGTTCCCACGACGCACATGGCTTTGCCAGAAACTCTGTTTAATGATCGGCCTTTCACCTCT
TCACTTATCCTTAGTCCCAGTAGCCAGGATACCTGATGGCCACGTGTGCCTTGGCCACGGGAGGCTGCTGAGATTGGCCACGTGGCTGGG
CTGGGTGGTGGCCTCACTCTCCCACAGAGCTGGAAATGGGGGGTGGGGGACAGATTCTTACGGAAATTTTTTTACCTGACTTGCTATGAA
AAAACTCATCACACAAGAAGAGAAACAGTAACCTCACTTTGAAAATTAGCTCCACTCAAGACTAGTCCACGAACGAGACCCGCCTTTTCT
ACACAGGATCCAAGGTCACGAGAAGCAGCCAGAGTGCCCCGCCTCCGCCGGCTCTGGTCTGCCATTCGCCAGTGCAGGGATCTGGCACGG
ACCAGATGTGGCGAATGGCAGCACAGCGCGGTGGCTGGGTCTGCACACTGGCCTCTGCAGCCAGATTTCTATATTGGGAGTTTTTTAAAA
AGACATTTCATAGCCAACAAGAATCAGTAGAAGTGCTGGGAGCAGCAGCTGGGGAAGCTGCCGCCCACGGGCTCTGCCCCTTCCAGCTGG
AGCCGCCCGTGCCTCCAGGGGCCAAGAGGATGATGTCGTGGCCTCCATTCTCGTTTCTATGCAGCCCCATAGTCCAAGGACACCCAGTCC
ACATCTACCATATAGCAAGTTTAGTAAGGGAAGGCAGCATACGTCCCAGGGACAGTGGGTTTGGATCTGTCTAGAACAGCGGTTTGTGGC
TGTGGCCCAGCTCCGAGAGTGATATTTGCTCTGGTAGGTGAGGGCCTGAGGGTACATTTCTCCACCTGTGCCCCCTCATGTTCACAGAGG
ATTTCAGCAGCTGCAACTGCGCACGCCAGGTGGGGAAGGGTGGGGGTGGGCCTGGTTGCCCCATGTTAGGAAATCACTACCAGTCAGGTG
GGGCTGGGGCTGGGTGGACAGGATCAGGATTCCCTTGAAAGCCCAGGCAGGGTGAGCAGTCCCAGTGGTCCTAGTGCCGCATCAGATCCA
GGTGGGTGAGGGCAGGAGGCCCCTGCGGAGGCAGCGTGGATCTGCCCACACATAGGCTACTGGAATAGTTTAACCCAGCAACTTTCCTTT
TTATAAAACAACAAATGGTTCAACTCTGTCTGCAAATTAACAGCTGAACACCTGCAACTGCAAATGTTTTTTGATCCGACGTACTGAAAT
AGGAAGTCATGCTCTTCCCACCCTCCACCCACCAGAGTGGAACCCGCTGCAAAATCCCCAGCCTTAATTCTTGCTTCAGGACCCAGACCG
GTGTCTTGCTCTAGGGCAACCCAGGGCAGAGGGGCCAGGTCTGCCCAGCGTTTACCACTGCTGTCAAGCCACAGCCCTTGGCCACCATAC
GGGCCATCCTCAGTGAGGCAGCCCCCCATAGGCTTCCGCCAAGCTCTGGTCCCGAAGAGGCTGTGCGAGCCCTTCCCGGCCCTCCCCAGG
GCCCCCCGCCCCCTCCTCTGCCTGCTGCGTGGAGGCAGCCATGGGAAGGAGCCCAGGGGAGCTGGCCTGGGGGAGCGAAGCCCATGTTCG
CTTCCTGACTTAGAGCTGGGGGGGGTGGGGGGTGGGGCTTGTTCCCCTGCAGTATCTGTTCTGTGAAGTTTGTTAAATGTAAGGAAAGCT
TAAATTCTTGTATCTTTAAAAGAGAAAATCTTATTTAACCCTTTTGTGTTCTAGATTTACTTACACACATAGCCTAGAGCTCAGTTTTAG

>15224_15224_1_CDK19-ZFAND3_CDK19_chr6_111136212_ENST00000368911_ZFAND3_chr6_38120011_ENST00000287218_length(amino acids)=149AA_BP=
MGSFPWLPPRSRQRRGRGALGRAGKGSHSLFGTRAWRKPMGGCLTEDGPYGGQGLWLDSSGKRWADLAPLPWVALEQDTGLGPEARIKAG

--------------------------------------------------------------
>15224_15224_2_CDK19-ZFAND3_CDK19_chr6_111136212_ENST00000368911_ZFAND3_chr6_38120011_ENST00000373391_length(transcript)=2698nt_BP=308nt
TGTGGCCGCCGAGGAGTCCCTTGCTGAAGGCGGACCGCGGAGCGGCGGGCGGCGGGCGGCGCGCGCGCGCGCGCGAGAGGCGGCTGTTGG
AGAAGTGGAGCGGCGGTCGCGGGGGGAGGAGGAGGAGGGACTGAGCGGCGGCGGCCCCCGCGTCCCGTGCCTCTATGGGGGAAGCAGACA
ATGGATTATGATTTCAAGGCGAAGCTGGCGGCGGAGCGGGAGCGGGTGGAGGATTTGTTTGAGTACGAAGGGTGCAAAGTGGGACGCGGC
ACCTACGGTCACGTCTACAAGGCGAGGCGGAAAGATGGGTTATGTGTTCTGTATGTTACATCGCCTCCCCGAGCAGCACGACTGCACATT
CGACCACATGGGCCGTGGCCGGGAGGAAGCCATCATGAAAATGGTGAAGCTGGACCGGAAAGTGGGGCGCTCCTGCCAGCGCATCGGGGA
GGGGTGCTCCTGAAGGCCAGGCATGGCCACCACGTGACGCTGTTCTTAGTTCACTAATGTTAGCCTTATTTAGGACAAAGTCAGCCAGAC
ACCTTGTACTGGGCACGCGTCAGACTGCAGCCAGTCCGTTTCCTTTCTTTAGCCAGCCATCCTGGTACTGTAGTTTAGGGGTTGATGGTG
GTTGAAATTGATTTCTGGCTGGTTACTAAGGTGCCTGCTAGCCATTGTATAAAATTAAAACATGAAGAATATTTTTTTTTTGAGCATGGC
TAGTGGATTTAAAACAACACATACCTGTCACTGCTGGAGTCAAACTTATAAAAAGCCTTAAGTGGAAAGTGTTCCAGACGGAGACTCTGA
GTTAATAGAGGAGTAGAAGCTGGTGTTAAAGTTCCCACGACGCACATGGCTTTGCCAGAAACTCTGTTTAATGATCGGCCTTTCACCTCT
TCACTTATCCTTAGTCCCAGTAGCCAGGATACCTGATGGCCACGTGTGCCTTGGCCACGGGAGGCTGCTGAGATTGGCCACGTGGCTGGG
CTGGGTGGTGGCCTCACTCTCCCACAGAGCTGGAAATGGGGGGTGGGGGACAGATTCTTACGGAAATTTTTTTACCTGACTTGCTATGAA
AAAACTCATCACACAAGAAGAGAAACAGTAACCTCACTTTGAAAATTAGCTCCACTCAAGACTAGTCCACGAACGAGACCCGCCTTTTCT
ACACAGGATCCAAGGTCACGAGAAGCAGCCAGAGTGCCCCGCCTCCGCCGGCTCTGGTCTGCCATTCGCCAGTGCAGGGATCTGGCACGG
ACCAGATGTGGCGAATGGCAGCACAGCGCGGTGGCTGGGTCTGCACACTGGCCTCTGCAGCCAGATTTCTATATTGGGAGTTTTTTAAAA
AGACATTTCATAGCCAACAAGAATCAGTAGAAGTGCTGGGAGCAGCAGCTGGGGAAGCTGCCGCCCACGGGCTCTGCCCCTTCCAGCTGG
AGCCGCCCGTGCCTCCAGGGGCCAAGAGGATGATGTCGTGGCCTCCATTCTCGTTTCTATGCAGCCCCATAGTCCAAGGACACCCAGTCC
ACATCTACCATATAGCAAGTTTAGTAAGGGAAGGCAGCATACGTCCCAGGGACAGTGGGTTTGGATCTGTCTAGAACAGCGGTTTGTGGC
TGTGGCCCAGCTCCGAGAGTGATATTTGCTCTGGTAGGTGAGGGCCTGAGGGTACATTTCTCCACCTGTGCCCCCTCATGTTCACAGAGG
ATTTCAGCAGCTGCAACTGCGCACGCCAGGTGGGGAAGGGTGGGGGTGGGCCTGGTTGCCCCATGTTAGGAAATCACTACCAGTCAGGTG
GGGCTGGGGCTGGGTGGACAGGATCAGGATTCCCTTGAAAGCCCAGGCAGGGTGAGCAGTCCCAGTGGTCCTAGTGCCGCATCAGATCCA
GGTGGGTGAGGGCAGGAGGCCCCTGCGGAGGCAGCGTGGATCTGCCCACACATAGGCTACTGGAATAGTTTAACCCAGCAACTTTCCTTT
TTATAAAACAACAAATGGTTCAACTCTGTCTGCAAATTAACAGCTGAACACCTGCAACTGCAAATGTTTTTTGATCCGACGTACTGAAAT
AGGAAGTCATGCTCTTCCCACCCTCCACCCACCAGAGTGGAACCCGCTGCAAAATCCCCAGCCTTAATTCTTGCTTCAGGACCCAGACCG
GTGTCTTGCTCTAGGGCAACCCAGGGCAGAGGGGCCAGGTCTGCCCAGCGTTTACCACTGCTGTCAAGCCACAGCCCTTGGCCACCATAC
GGGCCATCCTCAGTGAGGCAGCCCCCCATAGGCTTCCGCCAAGCTCTGGTCCCGAAGAGGCTGTGCGAGCCCTTCCCGGCCCTCCCCAGG
GCCCCCCGCCCCCTCCTCTGCCTGCTGCGTGGAGGCAGCCATGGGAAGGAGCCCAGGGGAGCTGGCCTGGGGGAGCGAAGCCCATGTTCG
CTTCCTGACTTAGAGCTGGGGGGGGTGGGGGGTGGGGCTTGTTCCCCTGCAGTATCTGTTCTGTGAAGTTTGTTAAATGTAAGGAAAGCT
TAAATTCTTGTATCTTTAAAAGAGAAAATCTTATTTAACCCTTTTGTGTTCTAGATTTACTTACACACATAGCCTAGAGCTCAGTTTTAG

>15224_15224_2_CDK19-ZFAND3_CDK19_chr6_111136212_ENST00000368911_ZFAND3_chr6_38120011_ENST00000373391_length(amino acids)=149AA_BP=
MGSFPWLPPRSRQRRGRGALGRAGKGSHSLFGTRAWRKPMGGCLTEDGPYGGQGLWLDSSGKRWADLAPLPWVALEQDTGLGPEARIKAG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDK19-ZFAND3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDK19-ZFAND3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDK19-ZFAND3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneC0087031Juvenile-Onset Still Disease1CTD_human
TgeneC3495559Juvenile arthritis1CTD_human
TgeneC3714758Juvenile psoriatic arthritis1CTD_human
TgeneC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human